Daxx

Summary

Gene Symbol: Daxx
Description: death domain associated protein
Alias: BING2, DAP6, EAP1, death domain-associated protein 6, CENP-C binding protein, ETS1-associated protein 1, Fas-binding protein, death-associated protein 6, fas death domain-associated protein
Species: human
Products:     Daxx

Top Publications

  1. Pluta A, Earnshaw W, Goldberg I. Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death. J Cell Sci. 1998;111 ( Pt 14):2029-41 pubmed
    ..CENP-C interactor, which we have named HDaxx, was characterized in detail and found to be homologous to murine Daxx, a protein identified through its ability to bind the death domain of Fas (CD95)...
  2. Perlman R, Schiemann W, Brooks M, Lodish H, Weinberg R. TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation. Nat Cell Biol. 2001;3:708-14 pubmed
    ..that interact physically with the cytoplasmic domain of the type II TGF-beta receptor to isolate the gene encoding Daxx - a protein associated with the Fas receptor that mediates activation of Jun amino-terminal kinase (JNK) and ..
  3. Kiriakidou M, Driscoll D, Lopez Guisa J, Strauss J. Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region. DNA Cell Biol. 1997;16:1289-98 pubmed
    Murine Daxx, a protein that binds to Fas and enhances Fas-mediated apoptosis through a signal transduction pathway involving the Jun amino-terminal kinase, was recently described...
  4. Yang X, Khosravi Far R, Chang H, Baltimore D. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell. 1997;89:1067-76 pubmed
    ..We have identified a novel signaling protein, termed Daxx, that binds specifically to the Fas death domain...
  5. Zizzi A, Montironi M, Mazzucchelli R, Scarpelli M, Lopez Beltran A, Cheng L, et al. Immunohistochemical analysis of chromatin remodeler DAXX in high grade urothelial carcinoma. Diagn Pathol. 2013;8:111 pubmed publisher
    The chromatin remodeler DAXX, a predominantly nuclear protein, regulates the status of chromatin organization...
  6. Escobar Cabrera E, Lau D, Giovinazzi S, Ishov A, McIntosh L. Structural characterization of the DAXX N-terminal helical bundle domain and its complex with Rassf1C. Structure. 2010;18:1642-53 pubmed publisher
    b>DAXX is a scaffold protein with diverse roles including transcription and cell cycle regulation...
  7. Croxton R, Puto L, De Belle I, Thomas M, Torii S, Hanaii F, et al. Daxx represses expression of a subset of antiapoptotic genes regulated by nuclear factor-kappaB. Cancer Res. 2006;66:9026-35 pubmed
    b>Daxx is a nuclear protein that localizes to PML oncogenic domains, sensitizes cells to apoptosis, and functions as a transcriptional repressor...
  8. Charette S, Lavoie J, Lambert H, Landry J. Inhibition of Daxx-mediated apoptosis by heat shock protein 27. Mol Cell Biol. 2000;20:7602-12 pubmed
    ..Here we show that phosphorylated dimers of HSP27 interact with Daxx, a mediator of Fas-induced apoptosis, preventing the interaction of Daxx with both Ask1 and Fas and blocking Daxx-..
  9. Salomoni P, Khelifi A. Daxx: death or survival protein?. Trends Cell Biol. 2006;16:97-104 pubmed
    The death domain-associated protein (Daxx) was originally cloned as a CD95 (FAS)-interacting protein and modulator of FAS-induced cell death...

More Information

Publications69

  1. Wethkamp N, Klempnauer K. Daxx is a transcriptional repressor of CCAAT/enhancer-binding protein beta. J Biol Chem. 2009;284:28783-94 pubmed publisher
    ..Here, we show that the activity of C/EBPbeta is negatively regulated by the transcriptional co-repressor Daxx. C/EBPbeta was found to directly interact with Daxx after overexpression as well as on the endogenous level...
  2. Schreiner S, Wimmer P, Sirma H, Everett R, Blanchette P, Groitl P, et al. Proteasome-dependent degradation of Daxx by the viral E1B-55K protein in human adenovirus-infected cells. J Virol. 2010;84:7029-38 pubmed publisher
    The death-associated protein Daxx found in PML (promyelocytic leukemia protein) nuclear bodies (PML-NBs) is involved in transcriptional regulation and cellular intrinsic antiviral resistence against incoming viruses...
  3. Ishov A, Vladimirova O, Maul G. Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRX. J Cell Sci. 2004;117:3807-20 pubmed
    ..Here, we show that the transcription repressor Daxx and the SWI/SNF protein ATRX are both associated with two intranuclear domains: ND10/PML bodies and heterochromatin...
  4. Tang J, Wu S, Liu H, Stratt R, Barak O, Shiekhattar R, et al. A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein. J Biol Chem. 2004;279:20369-77 pubmed
    Death domain-associated protein (Daxx) is a multi-functional protein that modulates both apoptosis and transcription...
  5. Muromoto R, Sugiyama K, Takachi A, Imoto S, Sato N, Yamamoto T, et al. Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1. J Immunol. 2004;172:2985-93 pubmed
    b>Daxx has been shown to play an essential role in type I IFN-alphabeta-mediated suppression of B cell development and apoptosis...
  6. Lewis P, Elsaesser S, Noh K, Stadler S, Allis C. Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc Natl Acad Sci U S A. 2010;107:14075-80 pubmed publisher
    ..We previously identified the death domain associated protein (Daxx) and the alpha-thalassemia X-linked mental retardation protein (ATRX) as H3.3-associated proteins...
  7. Chen L, Chen J. Daxx silencing sensitizes cells to multiple apoptotic pathways. Mol Cell Biol. 2003;23:7108-21 pubmed
    b>Daxx is a nuclear protein involved in apoptosis and transcriptional repression, and it interacts with the death receptor Fas, promyelocytic leukemia protein (PML), and several transcriptional repressors...
  8. Song J, Lee Y. Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization. J Biol Chem. 2003;278:47245-52 pubmed
    Overexpression of JNK binding domain inhibited glucose deprivation-induced JNK1 activation, relocalization of Daxx from the nucleus to the cytoplasm, and apoptosis signal-regulating kinase 1 (ASK1) oligomerization in human prostate ..
  9. Lehembre F, Muller S, Pandolfi P, Dejean A. Regulation of Pax3 transcriptional activity by SUMO-1-modified PML. Oncogene. 2001;20:1-9 pubmed
    ..The transcriptional activity of Pax3 was recently shown to be repressed by Daxx whereas the oncogenic fusion protein Pax3-FKHR is unresponsive to this repressive action...
  10. Ko Y, Kang Y, Park H, Seol W, Kim J, Kim T, et al. Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm. J Biol Chem. 2001;276:39103-6 pubmed
    Although Daxx (death-associated protein) was first reported to mediate the apoptotic signal from Fas to JNK in the cytoplasm, other data suggested that Daxx is mainly located in the nucleus as a transcriptional regulator...
  11. Zhang H, He J, Li J, Tian D, Gu L, Zhou M. Methylation of RASSF1A gene promoter is regulated by p53 and DAXX. FASEB J. 2013;27:232-42 pubmed publisher
    ..Herein, we report that this methylation is regulated by p53 and death-associated protein 6 (DAXX) in acute lymphoblastic leukemia (ALL)...
  12. Lin D, Fang H, Ma A, Huang Y, Pu Y, Jenster G, et al. Negative modulation of androgen receptor transcriptional activity by Daxx. Mol Cell Biol. 2004;24:10529-41 pubmed
    ..We report here that Daxx functions as a negative AR coregulator through direct protein-protein interactions...
  13. Woodhall D, Groves I, Reeves M, Wilkinson G, Sinclair J. Human Daxx-mediated repression of human cytomegalovirus gene expression correlates with a repressive chromatin structure around the major immediate early promoter. J Biol Chem. 2006;281:37652-60 pubmed
    ..Here we show that knockdown of human Daxx (hDaxx) expression, an important component of ND10, prior to infection with human cytomegalovirus resulted in ..
  14. Ryo A, Hirai A, Nishi M, Liou Y, Perrem K, Lin S, et al. A suppressive role of the prolyl isomerase Pin1 in cellular apoptosis mediated by the death-associated protein Daxx. J Biol Chem. 2007;282:36671-81 pubmed
    The death-associated protein Daxx is a multifunctional factor that regulates a variety of cellular processes, including transcription and apoptosis...
  15. Tavalai N, Papior P, Rechter S, Stamminger T. Nuclear domain 10 components promyelocytic leukemia protein and hDaxx independently contribute to an intrinsic antiviral defense against human cytomegalovirus infection. J Virol. 2008;82:126-37 pubmed
    ..Taken together, our data indicate that both proteins, PML and hDaxx, mediate an intrinsic immune response against HCMV infection by contributing independently to the silencing of HCMV IE gene expression. ..
  16. Huang Y, Shih H. Daxx positively modulates beta-catenin/TCF4-mediated transcriptional potential. Biochem Biophys Res Commun. 2009;386:762-8 pubmed publisher
    ..Here we report that Daxx binds to TCF4 and potentiates beta-catenin/TCF4-mediated transcriptional activation and target gene expression...
  17. Michaelson J, Bader D, Kuo F, Kozak C, Leder P. Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development. Genes Dev. 1999;13:1918-23 pubmed
    The mammalian Daxx gene has been identified in a diverse set of yeast interaction trap experiments. Although a facilitating role for Daxx in Fas-induced apoptosis has been suggested, Daxx's physiologic function remains unknown...
  18. Drané P, Ouararhni K, Depaux A, Shuaib M, Hamiche A. The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. Genes Dev. 2010;24:1253-65 pubmed publisher
    ..3 replication-independent deposition. We found that the death domain-associated protein DAXX and the chromatin remodeling factor ATRX (alpha-thalassemia/mental retardation syndrome protein) are specifically ..
  19. Emelyanov A, Kovac C, Sepulveda M, Birshtein B. The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells. J Biol Chem. 2002;277:11156-64 pubmed
    ..Using a yeast two-hybrid assay to identify potential coregulators of Pax5, we identified Daxx, a protein that is highly conserved, ubiquitously expressed, and essential for embryonic mouse development...
  20. Florin L, Schafer F, Sotlar K, Streeck R, Sapp M. Reorganization of nuclear domain 10 induced by papillomavirus capsid protein l2. Virology. 2002;295:97-107 pubmed
    ..In contrast to Sp100, Daxx was recruited to ND10 by L2 expression. Coimmunoprecipitation demonstrated interaction of the two proteins...
  21. Zydek M, Uecker R, Tavalai N, Stamminger T, Hagemeier C, Wiebusch L. General blockade of human cytomegalovirus immediate-early mRNA expression in the S/G2 phase by a nuclear, Daxx- and PML-independent mechanism. J Gen Virol. 2011;92:2757-69 pubmed publisher
    ..However, we found that neither Daxx nor PML, the main players of ND10-based immunity, are required for the block to viral gene expression in the S/G2 ..
  22. Michaelson J, Leder P. RNAi reveals anti-apoptotic and transcriptionally repressive activities of DAXX. J Cell Sci. 2003;116:345-52 pubmed
    The function of DAXX, a highly conserved mammalian gene, has remained controversial; this is due, in part, to its identification in a variety of yeast two-hybrid screens...
  23. Lukashchuk V, Everett R. Regulation of ICP0-null mutant herpes simplex virus type 1 infection by ND10 components ATRX and hDaxx. J Virol. 2010;84:4026-40 pubmed publisher
    ..Our results suggest that ATRX and hDaxx act as a complex that contributes to intrinsic antiviral resistance to HSV-1 infection, which is counteracted by ICP0. ..
  24. Marinoni I, Kurrer A, Vassella E, Dettmer M, Rudolph T, Banz V, et al. Loss of DAXX and ATRX are associated with chromosome instability and reduced survival of patients with pancreatic neuroendocrine tumors. Gastroenterology. 2014;146:453-60.e5 pubmed publisher
    ..Mutations in death domain-associated protein gene (DAXX) or ATR-X gene (ATRX) (which both encode proteins involved in chromatin remodeling) have been detected in 40% of ..
  25. Shih H, Chang C, Kuo H, Lin D. Daxx mediates SUMO-dependent transcriptional control and subnuclear compartmentalization. Biochem Soc Trans. 2007;35:1397-400 pubmed
    ..protein)-binding protein] co-activator results in the recruitment of a transcriptional co-repressor Daxx, thereby causing transcriptional repression...
  26. Lindsay C, Scholz A, Morozov V, Ishov A. Daxx shortens mitotic arrest caused by paclitaxel. Cell Cycle. 2007;6:1200-4 pubmed
    ..By screening a cohort of breast cancer cell lines, we observed a correlation between level of protein Daxx and response to paclitaxel...
  27. Jiao Y, Shi C, Edil B, de Wilde R, Klimstra D, Maitra A, et al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science. 2011;331:1199-203 pubmed publisher
    ..in genes encoding either of the two subunits of a transcription/chromatin remodeling complex consisting of DAXX (death-domain-associated protein) and ATRX (? thalassemia/mental retardation syndrome X-linked)...
  28. Tang J, Qu L, Zhang J, Wang W, Michaelson J, Degenhardt Y, et al. Critical role for Daxx in regulating Mdm2. Nat Cell Biol. 2006;8:855-62 pubmed
    ..Here, we show that death domain-associated protein (Daxx) is required for Mdm2 stability...
  29. Lin D, Huang Y, Jeng J, Kuo H, Chang C, Chao T, et al. Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. Mol Cell. 2006;24:341-54 pubmed
    ..b>Daxx, a transcriptional corepressor, was reported to repress the transcriptional potential of several transcription ..
  30. Kuo H, Chang C, Jeng J, Hu H, Lin D, Maul G, et al. SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx. Proc Natl Acad Sci U S A. 2005;102:16973-8 pubmed
    ..Furthermore, we demonstrated an interaction of SUMO-1-modified CBP with the transcriptional corepressor Daxx and an essential role of Daxx in mediating SUMO-dependent transcriptional regulation of CBP through histone ..
  31. Gostissa M, Morelli M, Mantovani F, Guida E, Piazza S, Collavin L, et al. The transcriptional repressor hDaxx potentiates p53-dependent apoptosis. J Biol Chem. 2004;279:48013-23 pubmed
    ..Our results therefore underline the central role of hDaxx in modulating the apoptotic threshold upon several stimuli and identify it as a possible integrating factor that coordinates the response of p53 family members. ..
  32. Li R, Pei H, Watson D, Papas T. EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes. Oncogene. 2000;19:745-53 pubmed
    ..region was used as bait and an interaction was identified with the Daxx protein, referred to as EAP1 (ETS1 Associated Protein 1)/Daxx. This interactin has been shown to exist in yeast and in vitro...
  33. Tang J, Agrawal T, Cheng Q, Qu L, Brewer M, Chen J, et al. Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation. PLoS ONE. 2013;8:e55813 pubmed publisher
    ..p53 is regulated by the ubiquitin ligase Mdm2. The optimal function of Mdm2 requires Daxx, which stabilizes Mdm2 through the deubiquitinase Hausp/USP7 and also directly promotes Mdm2's ubiquitin ligase ..
  34. Li H, Leo C, Zhu J, Wu X, O Neil J, Park E, et al. Sequestration and inhibition of Daxx-mediated transcriptional repression by PML. Mol Cell Biol. 2000;20:1784-96 pubmed
    ..We isolated the Fas-binding protein Daxx as a PML-interacting protein in a yeast two-hybrid screen...
  35. de Wilde R, Heaphy C, Maitra A, Meeker A, Edil B, Wolfgang C, et al. Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors. Mod Pathol. 2012;25:1033-9 pubmed publisher
    ..pancreatic neuroendocrine tumors harbor mutations in either ATRX (alpha thalassemia/mental retardation X-linked) or DAXX (death domain-associated protein)...
  36. Hollenbach A, McPherson C, Mientjes E, Iyengar R, Grosveld G. Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. J Cell Sci. 2002;115:3319-30 pubmed
    Human Daxx is a protein that functions, in part, as a transcriptional co-repressor through its interaction with a growing number of nuclear, DNA-associated proteins...
  37. Heaphy C, de Wilde R, Jiao Y, Klein A, Edil B, Shi C, et al. Altered telomeres in tumors with ATRX and DAXX mutations. Science. 2011;333:425 pubmed publisher
    The proteins encoded by ATRX and DAXX participate in chromatin remodeling at telomeres and other genomic sites...
  38. Chu Y, Yang X. SUMO E3 ligase activity of TRIM proteins. Oncogene. 2011;30:1108-16 pubmed publisher
    ..Given the large number of TRIM proteins, our results may greatly expand the identified SUMO E3s. Furthermore, TRIM E3 activity may be an important contributor to SUMOylation specificity and the versatile functions of TRIM proteins. ..
  39. Zhao L, Colosimo A, Liu Y, Wan Y, Liao D. Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by Daxx. J Virol. 2003;77:11809-21 pubmed
    ..We found that Daxx binds to the E1B 55-kDa protein in a yeast two-hybrid screen. The two proteins interact through their C termini...
  40. Li Q, Wang X, Wu X, Rui Y, Liu W, Wang J, et al. Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death. Cancer Res. 2007;67:66-74 pubmed
    b>Daxx, a death domain-associated protein, has been implicated in proapoptosis, antiapoptosis, and transcriptional regulation...
  41. Ishov A, Sotnikov A, Negorev D, Vladimirova O, Neff N, Kamitani T, et al. PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1. J Cell Biol. 1999;147:221-34 pubmed
    ..We identified the adapter protein Daxx and BML, the RecQ helicase missing in Bloom syndrome, as new ND10-associated proteins...
  42. Ivanchuk S, Mondal S, Rutka J. p14ARF interacts with DAXX: effects on HDM2 and p53. Cell Cycle. 2008;7:1836-50 pubmed
    ..In this report, we demonstrate an interaction between ARF and DAXX, a highly conserved protein with identified roles in the regulation of gene expression...
  43. Song M, Song S, Kim S, Oh H, Lim D. The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex. EMBO J. 2008;27:1863-74 pubmed publisher
    ..Importantly, RASSF1A associates with MDM2 and death-domain-associated protein (DAXX) in the nucleus, thereby disrupting the interactions between MDM2, DAXX, and the deubiquitinase, HAUSP, and ..
  44. Lindsay C, Morozov V, Ishov A. PML NBs (ND10) and Daxx: from nuclear structure to protein function. Front Biosci. 2008;13:7132-42 pubmed
    ..One of the few "constitutive" components of PML NBs is the death domain-associated protein Daxx. While PML NBs are the most obvious depositories of Daxx, there are multiple alternative localization of this ..
  45. Wethkamp N, Hanenberg H, Funke S, Suschek C, Wetzel W, Heikaus S, et al. Daxx-beta and Daxx-gamma, two novel splice variants of the transcriptional co-repressor Daxx. J Biol Chem. 2011;286:19576-88 pubmed publisher
    b>Daxx is involved in transcriptional control and apoptosis...
  46. Leung J, Ghosal G, Wang W, Shen X, Wang J, Li L, et al. Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress. J Biol Chem. 2013;288:6342-50 pubmed publisher
    ..In addition, we identified ATRX as a binding partner of MRE11-RAD50-NBS1 (MRN) complex. Together, these results suggest a non-canonical function of ATRX in guarding genomic stability. ..
  47. Kwan P, Lau C, Chiu Y, Man C, Liu J, Tang K, et al. Daxx regulates mitotic progression and prostate cancer predisposition. Carcinogenesis. 2013;34:750-9 pubmed publisher
    ..In this study, we identified Daxx as a novel APC/C inhibitor frequently overexpressed in prostate cancer...
  48. Cantrell S, Bresnahan W. Human cytomegalovirus (HCMV) UL82 gene product (pp71) relieves hDaxx-mediated repression of HCMV replication. J Virol. 2006;80:6188-91 pubmed
  49. Hwang J, Kalejta R. In vivo analysis of protein sumoylation induced by a viral protein: Detection of HCMV pp71-induced Daxx sumoylation. Methods. 2011;55:160-5 pubmed publisher
    ..laboratory has previously demonstrated that the human cytomegalovirus (HCMV) virion tegument protein pp71 binds to Daxx, a cellular transcriptional co-repressor, and promotes its sumoylation...
  50. Chen A, Wang P, Yang Y, Huang Y, Yeh J, Chou Y, et al. SUMO regulates the cytoplasmonuclear transport of its target protein Daxx. J Cell Biochem. 2006;98:895-911 pubmed
    It is known that Fas death domain-associated protein (Daxx) possesses both putative nuclear and cytoplasmic functions. However, the nuclear transport mechanism is largely unknown...
  51. Xue Y, Gibbons R, Yan Z, Yang D, McDowell T, Sechi S, et al. The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies. Proc Natl Acad Sci U S A. 2003;100:10635-40 pubmed
    ..By immunoprecipitation from HeLa extract, we found that ATRX is in a complex with transcription cofactor Daxx. The following evidence supports that ATRX and Daxx are components of an ATP-dependent chromatin-remodeling complex:..
  52. Kim E, Park J, Um S. Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML. Nucleic Acids Res. 2003;31:5356-67 pubmed
    ..We found that the p53 family members were functionally associated with Daxx, which was described originally as a cytoplasmic mediator of Fas signaling, but has been identified recently as a ..
  53. Muromoto R, Sugiyama K, Yamamoto T, Oritani K, Shimoda K, Matsuda T. Physical and functional interactions between Daxx and TSG101. Biochem Biophys Res Commun. 2004;316:827-33 pubmed
    b>Daxx has been reported to mediate the Fas/JNK-dependent signals in the cytoplasm. However, several evidences have suggested that Daxx is located mainly in the nucleus and functions as a transcriptional regulator...
  54. Knipscheer P, Flotho A, Klug H, Olsen J, van Dijk W, Fish A, et al. Ubc9 sumoylation regulates SUMO target discrimination. Mol Cell. 2008;31:371-82 pubmed publisher
    ..The crystal structure of sumoylated Ubc9 demonstrates how the newly created binding interface can provide a gain in affinity otherwise provided by E3 ligases. ..
  55. Goldberg A, Banaszynski L, Noh K, Lewis P, Elsaesser S, Stadler S, et al. Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell. 2010;140:678-91 pubmed publisher
    ..Immunoaffinity purification and mass spectrometry reveal that the proteins Atrx and Daxx associate with H3.3 in a Hira-independent manner. Atrx is required for Hira-independent localization of H3...
  56. Tang J, Qu L, Pang M, Yang X. Daxx is reciprocally regulated by Mdm2 and Hausp. Biochem Biophys Res Commun. 2010;393:542-5 pubmed publisher
    b>Daxx is a multifunctional protein, regulating a wide range of important functions including apoptosis and transcription. However, the way Daxx is regulated is poorly understood...
  57. Kitagawa D, Kajiho H, Negishi T, Ura S, Watanabe T, Wada T, et al. Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. EMBO J. 2006;25:3286-97 pubmed
    ..Here, we report that the nuclear components Daxx and Ras-association domain family 1C (RASSF1C) link DNA damage to SAPK/JNK activation in HeLa cells...
  58. Saffert R, Kalejta R. Human cytomegalovirus gene expression is silenced by Daxx-mediated intrinsic immune defense in model latent infections established in vitro. J Virol. 2007;81:9109-20 pubmed
    ..pp71 neutralizes the Daxx-mediated cellular intrinsic immune defense that silences IE gene expression by generating a repressive chromatin ..
  59. Chang H, Nishitoh H, Yang X, Ichijo H, Baltimore D. Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx. Science. 1998;281:1860-3 pubmed
    ..The Fas death receptor can activate the Jun NH2-terminal kinase (JNK) pathway through the receptor-associated protein Daxx. Daxx was found to activate the JNK kinase kinase ASK1, and overexpression of a kinase-deficient ASK1 mutant ..
  60. Chang C, Lin D, Fang H, Chen R, Shih H. Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4. J Biol Chem. 2005;280:10164-73 pubmed
    b>Daxx has been shown to function as an apoptosis regulator and transcriptional repressor via its interaction with various cytoplasmic and nuclear proteins...