DAX 1

Summary

Gene Symbol: DAX 1
Description: nuclear receptor subfamily 0 group B member 1
Alias: AHC, AHCH, AHX, DAX-1, DAX1, DSS, GTD, HHG, NROB1, SRXY2, nuclear receptor subfamily 0 group B member 1, DSS-AHC critical region on the X chromosome protein 1, nuclear hormone receptor, nuclear receptor DAX-1, truncated nuclear receptor subfamily 0 group B member 1
Species: human
Products:     DAX 1

Top Publications

  1. Guo W, Burris T, McCabe E. Expression of DAX-1, the gene responsible for X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism, in the hypothalamic-pituitary-adrenal/gonadal axis. Biochem Mol Med. 1995;56:8-13 pubmed
    DAX-1, an orphan member of the nuclear hormone receptor superfamily, is responsible for X-linked adrenal hypoplasia congenita (AHC) and the frequently associated hypogonadotropic hypogonadism (HH)...
  2. Zazopoulos E, Lalli E, Stocco D, Sassone Corsi P. DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis. Nature. 1997;390:311-5 pubmed
    ..Our results establish DAX-1 as the first member of the nuclear receptor superfamily with novel DNA-binding features and reveal that it has regulatory properties critical to the understanding of its physiological functions. ..
  3. Ozisik G, Mantovani G, Achermann J, Persani L, Spada A, Weiss J, et al. An alternate translation initiation site circumvents an amino-terminal DAX1 nonsense mutation leading to a mild form of X-linked adrenal hypoplasia congenita. J Clin Endocrinol Metab. 2003;88:417-23 pubmed
    Mutations in DAX1 [dosage-sensitive sex reversal-adrenal hypoplasia congenita (AHC) critical region on the X chromosome gene 1; NR0B1] cause X-linked AHC, a disease characterized by primary adrenal failure in infancy or childhood and ..
  4. Zanaria E, Muscatelli F, Bardoni B, Strom T, Guioli S, Guo W, et al. An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita. Nature. 1994;372:635-41 pubmed
    ..DAX-1 encodes a new member of the nuclear hormone receptor superfamily displaying a novel DNA-binding domain...
  5. Caron P, Imbeaud S, Bennet A, Plantavid M, Camerino G, Rochiccioli P. Combined hypothalamic-pituitary-gonadal defect in a hypogonadic man with a novel mutation in the DAX-1 gene. J Clin Endocrinol Metab. 1999;84:3563-9 pubmed
    ..In conclusion, we report a novel mutation in the DAX-1 gene in patients with AHC and HH...
  6. Tabarin A, Achermann J, Recan D, Bex V, Bertagna X, Christin Maitre S, et al. A novel mutation in DAX1 causes delayed-onset adrenal insufficiency and incomplete hypogonadotropic hypogonadism. J Clin Invest. 2000;105:321-8 pubmed
    Mutations in the DAX1 gene cause X-linked adrenal hypoplasia congenita (AHC) and hypogonadotropic hypogonadism (HHG)...
  7. Zhang H, Slewa A, Janssen E, Skaland I, Yu Y, Gudlaugsson E, et al. The prognostic value of the orphan nuclear receptor DAX-1 (NROB1) in node-negative breast cancer. Anticancer Res. 2011;31:443-9 pubmed
    ..0001, HR=6.1). In operable node-negative breast cancer, strong DAX-1 expression is associated with excellent survival. ..
  8. Takahashi T, Shoji Y, Haraguchi N, Takahashi I, Takada G. Active hypothalamic-pituitary-gonadal axis in an infant with X-linked adrenal hypoplasia congenita. J Pediatr. 1997;130:485-8 pubmed
    ..We speculate that sometime between infancy and puberty this mutation in the DAX-1 gene leads to an inability to activate the reproductive axis from its childhood suppression; thus puberty will not develop in this infant. ..
  9. Frapsauce C, Ravel C, Legendre M, Sibony M, Mandelbaum J, Donadille B, et al. Birth after TESE-ICSI in a man with hypogonadotropic hypogonadism and congenital adrenal hypoplasia linked to a DAX-1 (NR0B1) mutation. Hum Reprod. 2011;26:724-8 pubmed publisher
    b>DAX1/NR0B1 mutations are responsible for X-linked congenital adrenal hypoplasia (AHC) associated with hypogonadotropic hypogonadism (HH). Few data are available concerning testicular function and fertility in men with DAX1 mutations...

More Information

Publications111 found, 100 shown here

  1. Muscatelli F, Strom T, Walker A, Zanaria E, Recan D, Meindl A, et al. Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. Nature. 1994;372:672-6 pubmed
    ..DSS-AHC critical region on the X, gene 1) gene was isolated and found to encode a new member of the nuclear hormone receptor family...
  2. Achermann J, Meeks J, Jameson J. Phenotypic spectrum of mutations in DAX-1 and SF-1. Mol Cell Endocrinol. 2001;185:17-25 pubmed
    ..Targeted mutagenesis of Dax1 (Ahch) in mice reveals an additional role in testis development and spermatogenesis...
  3. Landau Z, Hanukoglu A, Sack J, Goldstein N, Weintrob N, Eliakim A, et al. Clinical and genetic heterogeneity of congenital adrenal hypoplasia due to NR0B1 gene mutations. Clin Endocrinol (Oxf). 2010;72:448-54 pubmed publisher
    X-linked adrenal hypoplasia congenita (AHC) is a rare disorder caused by mutations or complete deletion of the NR0B1 gene that encodes the DAX-1 protein, an orphan member of the nuclear receptor superfamily...
  4. Swain A, Narvaez V, Burgoyne P, Camerino G, Lovell Badge R. Dax1 antagonizes Sry action in mammalian sex determination. Nature. 1998;391:761-7 pubmed
    b>DAX1, which encodes an unusual member of the nuclear hormone-receptor superfamily, is a gene that may be responsible for a sex-reversal syndrome in humans, referred to as dosage-sensitive sex reversal, in which XY individuals carrying ..
  5. Bardoni B, Zanaria E, Guioli S, Floridia G, Worley K, Tonini G, et al. A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal. Nat Genet. 1994;7:497-501 pubmed
    ..We have named this locus DSS (Dosage Sensitive Sex reversal) and localized it to a 160 kilobase region of chromosome Xp21, adjacent to the ..
  6. Saito S, Ito K, Suzuki T, Utsunomiya H, Akahira J, Sugihashi Y, et al. Orphan nuclear receptor DAX-1 in human endometrium and its disorders. Cancer Sci. 2005;96:645-52 pubmed
  7. Zhang H, Thomsen J, Johansson L, Gustafsson J, Treuter E. DAX-1 functions as an LXXLL-containing corepressor for activated estrogen receptors. J Biol Chem. 2000;275:39855-9 pubmed
    We have discovered that the orphan receptor DAX-1 (NROB1) interacts with the estrogen receptors ERalpha and ERbeta...
  8. Holter E, Kotaja N, MAKELA S, Strauss L, Kietz S, Janne O, et al. Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1. Mol Endocrinol. 2002;16:515-28 pubmed
    DAX-1 (NROB1) is an atypical member of the nuclear receptor family that is predominantly expressed in mammalian reproductive tissues...
  9. Conde I, Alfaro J, Fraile B, Ruiz A, Paniagua R, Arenas M. DAX-1 expression in human breast cancer: comparison with estrogen receptors ER-alpha, ER-beta and androgen receptor status. Breast Cancer Res. 2004;6:R140-8 pubmed
  10. Li N, Liu R, Zhang H, Yang J, Sun S, Zhang M, et al. Seven novel DAX1 mutations with loss of function identified in Chinese patients with congenital adrenal hypoplasia. J Clin Endocrinol Metab. 2010;95:E104-11 pubmed publisher
    ..sex reversal, adrenal hypoplasia congenital critical region on the X chromosome, gene 1; also called NROB1) mutations are responsible for adrenal failure and hypogonadotropic hypogonadism in patients with adrenal ..
  11. Mantovani G, Ozisik G, Achermann J, Romoli R, Borretta G, Persani L, et al. Hypogonadotropic hypogonadism as a presenting feature of late-onset X-linked adrenal hypoplasia congenita. J Clin Endocrinol Metab. 2002;87:44-8 pubmed
    ..This case demonstrates that partial loss-of-function mutations in DAX1 can present with hypogonadotropic hypogonadism and covert adrenal failure in adulthood...
  12. Mantovani G, De Menis E, Borretta G, Radetti G, Bondioni S, Spada A, et al. DAX1 and X-linked adrenal hypoplasia congenita: clinical and molecular analysis in five patients. Eur J Endocrinol. 2006;154:685-9 pubmed
    Mutations in the gene coding for the orphan nuclear receptor DAX1 cause X-linked adrenal hypoplasia congenita (AHC). Affected boys usually present with primary adrenal failure in early infancy or childhood...
  13. Lin L, Gu W, Ozisik G, To W, Owen C, Jameson J, et al. Analysis of DAX1 (NR0B1) and steroidogenic factor-1 (NR5A1) in children and adults with primary adrenal failure: ten years' experience. J Clin Endocrinol Metab. 2006;91:3048-54 pubmed
    ..The nuclear receptors DAX1 (NR0B1) and steroidogenic factor-1 (SF1/Ad4BP, NR5A1) play an important role in adrenal development and function, ..
  14. Nakamura Y, Suzuki T, Arai Y, Sasano H. Nuclear receptor DAX1 in human prostate cancer: a novel independent biological modulator. Endocr J. 2009;56:39-44 pubmed
    The orphan nuclear receptor DAX1 (dosage-sensitive sex reversal-AHC critical region on the X chromosome gene 1; NR0B1) has been known for its various roles in human development, specifically sex determination and steroidogenesis...
  15. Brown P, Scobie G, Townsend J, Bayne R, Seckl J, Saunders P, et al. Identification of a novel missense mutation that is as damaging to DAX-1 repressor function as a nonsense mutation. J Clin Endocrinol Metab. 2003;88:1341-9 pubmed
    Mutations in the DAX-1 (NROB1) gene result in X-linked congenital adrenal hypoplasia (AHC) and hypogonadotropic hypogonadism...
  16. Bizzarri C, Olivini N, Pedicelli S, Marini R, Giannone G, Cambiaso P, et al. Congenital primary adrenal insufficiency and selective aldosterone defects presenting as salt-wasting in infancy: a single center 10-year experience. Ital J Pediatr. 2016;42:73 pubmed publisher
    ..Four familial cases of X-linked adrenal hypoplasia congenita due to NROB1 gene mutation were identified...
  17. Hu X, Deng J, Yu T, Chen S, Ge Y, Zhou Z, et al. ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides. Gastroenterology. 2019;156:1098-1111 pubmed publisher
    ..in intestinal epithelial cells (Atf4ΔIEC mice) and Atf4-floxed mice (controls) were given dextran sodium sulfate (DSS) to induce colitis...
  18. Tian Y, Xu J, Li Y, Zhao R, Du S, Lv C, et al. MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice. Gastroenterology. 2019;: pubmed publisher
    ..of Mir31 specifically in the intestinal epithelium (MIR31 conditional knockouts) were given dextran sulfate sodium (DSS) or 2,4,6-trinitrobenzene sulfonic acid (TNBS) to induce colitis...
  19. Li Z, Sun B, Gong T, Guo S, Zhang J, Wang J, et al. GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Downregulating Expression of GNAI2. Gastroenterology. 2019;: pubmed publisher
    ..and/or Gnai3 or conditional disruption of Gnai2 in CD11c+ or epithelial cells were given dextran sulfate sodium (DSS) to induce colitis followed by azoxymethane (AOM) to induce carcinogenesis; some mice were given an antibody ..
  20. Hua F, Shang S, Yang Y, Zhang H, Xu T, Yu J, et al. TRIB3 Interacts With β-Catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis. Gastroenterology. 2019;156:708-721.e15 pubmed publisher
    ..Knockdown of TRIB3 decreases colon neoplasia in mice, migration of CRC cells, and their growth as xenograft tumors in mice. Strategies to block TRIB3 activity might be developed for treatment of CRC. ..
  21. Kim H, Kim M, Park Y, Park I, Kim T, Yang S, et al. Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice. Gastroenterology. 2017;152:616-630 pubmed publisher
    ..Dextran sodium sulfate (DSS) was given to induce colitis in C57/BL6 (control) mice, as well as in mice with disruption of the ..
  22. Wang R, Wu G, Du L, Shao J, Liu F, Yang Z, et al. Semi-bionic extraction of compound turmeric protects against dextran sulfate sodium-induced acute enteritis in rats. J Ethnopharmacol. 2016;190:288-300 pubmed publisher
    ..of semi-bionic extraction of compound turmeric (SET) on acute enteritis (AE) induced by dextran sulfate sodium (DSS) in rats. SET was extracted in artificial gastric juice or artificial intestinal juice and mixed...
  23. Geng H, Bu H, Liu F, Wu L, Pfeifer K, Chou P, et al. In Inflamed Intestinal Tissues and Epithelial Cells, Interleukin 22 Signaling Increases Expression of H19 Long Noncoding RNA, Which Promotes Mucosal Regeneration. Gastroenterology. 2018;155:144-155 pubmed publisher
    ..reaction and in situ hybridization analyses of intestinal tissues from mice with sepsis or dextran sulfate sodium (DSS)-induced mucosal wound healing and patients with ulcerative colitis compared to healthy individuals (controls)...
  24. Zheng Z, Wu B, Zhang M, Lu W, Luo F. [Recurrent anorexia and pigmentation of skin for more than two months in an infant]. Zhongguo Dang Dai Er Ke Za Zhi. 2017;19:926-929 pubmed
    ..The clinical manifestations of this disease include hypertriglyceridemia, congenital adrenal hypoplasia (AHC), Duchenne muscular dystrophy, and mental retardation...
  25. He C, Yu T, Shi Y, Ma C, Yang W, Fang L, et al. MicroRNA 301A Promotes Intestinal Inflammation and Colitis-Associated Cancer Development by Inhibiting BTG1. Gastroenterology. 2017;152:1434-1448.e15 pubmed publisher
    ..was induced in knockout, transgenic, and control (C57BL/B6) mice by administration of dextran sulfate sodium (DSS), and mice were given azoxymethane to induce colorectal carcinogenesis...
  26. Rtibi K, Grami D, Wannes D, Selmi S, Amri M, Sebai H, et al. Ficus carica aqueous extract alleviates delayed gastric emptying and recovers ulcerative colitis-enhanced acute functional gastrointestinal disorders in rats. J Ethnopharmacol. 2018;224:242-249 pubmed publisher
    ..FCAE) on delayed gastric emptying and ulcerative colitis-improved motility disturbances in dextran sulfate sodium (DSS)-induced acute colitis in rats. Wistar rats were assigned randomly and received 5% DSS for seven days...
  27. Niu G, Liu L, Zheng L, Zhang H, Shih D, Zhang X. Mesenchymal stem cell transplantation improves chronic colitis-associated complications through inhibiting the activity of toll-like receptor-4 in mice. BMC Gastroenterol. 2018;18:127 pubmed publisher
    ..hepatobiliary complications using mouse chronic colitis models induced by dextran sulfate sodium (DSS). DSS-induced mouse chronic colitis models were established and treated with MSCs...
  28. Srůtková D, Schwarzer M, Hudcovic T, Zakostelska Z, Dráb V, Spanová A, et al. Bifidobacterium longum CCM 7952 Promotes Epithelial Barrier Function and Prevents Acute DSS-Induced Colitis in Strictly Strain-Specific Manner. PLoS ONE. 2015;10:e0134050 pubmed publisher
    ..A mouse model of dextran sulphate sodium (DSS)-induced colitis was used to compare their beneficial effects in vivo...
  29. Saud S, Li W, Gray Z, Matter M, Colburn N, Young M, et al. Diallyl Disulfide (DADS), a Constituent of Garlic, Inactivates NF-κB and Prevents Colitis-Induced Colorectal Cancer by Inhibiting GSK-3β. Cancer Prev Res (Phila). 2016;9:607-15 pubmed publisher
    ..diet of FVB/N mice treated with chemical carcinogen azoxymethane (AOM) and colonic irritant dextran sodium sulfate (DSS) resulted in the reduction in tumor incidence, tumor number, and tumor burden by 21.54%, 47.3%, and 66...
  30. Strom T, Carr M, Zager J, Naghavi A, Smith F, Cruse C, et al. Radiation Therapy is Associated with Improved Outcomes in Merkel Cell Carcinoma. Ann Surg Oncol. 2016;23:3572-3578 pubmed publisher
    ..locoregional control (LRC), disease-free survival (DFS), overall survival (OS), and disease-specific survival (DSS). Median follow-up was 33 months. Treatment with RT was associated with improved 3-year LC (91.2 vs. 76...
  31. Liu Y, Yuan J, Zhang H, Jiang Y, Qin G. A novel DAX-1 mutation in two male siblings presenting with precocious puberty and late-onset hypogonadotropic hypogonadism. J Pediatr Endocrinol Metab. 2017;30:349-353 pubmed publisher
    Background The DAX-1 gene is associated with X-linked adrenal hypoplasia congenita (AHC). Our objective was to compare the DAX-1 gene sequence of two male siblings exhibiting different clinical manifestations of AHC...
  32. Garvey L, Pavese N, Ramlackhansingh A, Thomson E, Allsop J, Politis M, et al. Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation. PLoS ONE. 2012;7:e38980 pubmed publisher
    ..Poorer cognitive performance and disturbance of cerebral metabolites are observed in subjects with aHC,V compared to subjects with HIVmono...
  33. Lee C, Ha G, Kim J, Kim S. Modulation in Natriuretic Peptides System in Experimental Colitis in Rats. Dig Dis Sci. 2016;61:1060-8 pubmed publisher
    ..Experimental colitis was induced by an intake of 5 % dextran sulfate sodium (DSS) dissolved in tap water for 7 days...
  34. Jang J, Lee K, Ko S. Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis. Mediators Inflamm. 2016;2016:9275083 pubmed publisher
    ..Colitis was induced by 4% dextran sulfate sodium (DSS) in the drinking water of male C57BL/6 mice, for 7 consecutive days...
  35. Duyen H, Cerny D, Trung D, Pang J, Velumani S, Toh Y, et al. Skin dendritic cell and T cell activation associated with dengue shock syndrome. Sci Rep. 2017;7:14224 pubmed publisher
    ..skin biopsies and contemporaneous blood samples from patients within 24?hours of onset of dengue shock syndrome (DSS), and from healthy controls...
  36. Rao M, Padhy R, Das M. Episodes of the epidemiological factors correlated with prevailing viral infections with dengue virus and molecular characterization of serotype-specific dengue virus circulation in eastern India. Infect Genet Evol. 2018;58:40-49 pubmed publisher
    ..and sequential infections put people at greater risk for dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS)...
  37. Tahkola K, Mecklin J, Wirta E, Ahtiainen M, Helminen O, Böhm J, et al. High immune cell score predicts improved survival in pancreatic cancer. Virchows Arch. 2018;472:653-665 pubmed publisher
    ..High IS and low histological grade were significantly associated with better disease-specific survival (DSS) and overall survival (OS). The 5-year DSS rate for low, moderate, and high IS groups were 5.0, 15.2, and 33...
  38. Achiwa K, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Hayashi K, et al. DSS colitis promotes tumorigenesis and fibrogenesis in a choline-deficient high-fat diet-induced NASH mouse model. Biochem Biophys Res Commun. 2016;470:15-21 pubmed publisher
    ..Moreover, in a dextran sodium sulfate (DSS)-induced colitis model in mice, a high-fat diet increases portal LPS level and promotes hepatic inflammation and ..
  39. Almadori G, Rigante M, Bussu F, Parrilla C, Gallus R, Barone Adesi L, et al. Impact of microvascular free flap reconstruction in oral cavity cancer: our experience in 130 cases. Acta Otorhinolaryngol Ital. 2015;35:386-93 pubmed publisher
    ..Disease-specific survival (DSS) curves were obtained using the Kaplan-Meier method...
  40. Rauscher I, Maurer T, Beer A, Graner F, Haller B, Weirich G, et al. Value of 68Ga-PSMA HBED-CC PET for the Assessment of Lymph Node Metastases in Prostate Cancer Patients with Biochemical Recurrence: Comparison with Histopathology After Salvage Lymphadenectomy. J Nucl Med. 2016;57:1713-1719 pubmed
    The purpose of this study was to evaluate the accuracy of Glu-NH-CO-NH-Lys-(Ahx)-[68Ga(HBED-CC)] PET compared with morphologic imaging for the assessment of lymph node metastases (LNM) in patients with recurrent prostate ..
  41. Ji T, Takabayashi H, Mao M, Han X, Xue X, Brazil J, et al. Regulation and function of bone morphogenetic protein signaling in colonic injury and inflammation. Am J Physiol Gastrointest Liver Physiol. 2017;312:G24-G33 pubmed publisher
    ..floxed alleles of BMP receptor 1A (villin-Cre;Bmpr1aflox/flox) were treated with dextran sodium sulfate (DSS) to induce colonic injury and inflammation...
  42. Niedworok C, Tschirdewahn S, Reis H, Lehmann N, Szücs M, Nyirády P, et al. Serum Chromogranin A as a Complementary Marker for the Prediction of Prostate Cancer-Specific Survival. Pathol Oncol Res. 2017;23:643-650 pubmed publisher
    ..was not tested for correlation with the most significant study end-point of long-term disease-specific survival (DSS)...
  43. Vargas Casanova Y, Rodríguez Guerra J, Umaña Pérez Y, Leal Castro A, Almanzar Reina G, García Castañeda J, et al. Antibacterial Synthetic Peptides Derived from Bovine Lactoferricin Exhibit Cytotoxic Effect against MDA-MB-468 and MDA-MB-231 Breast Cancer Cell Lines. Molecules. 2017;22: pubmed publisher
    ..The dimeric peptide (RRWQWR)₂K-Ahx exhibited the highest antibacterial activity against the tested bacterial strains...
  44. Keski Säntti H, Back L, Lassus P, Koivunen P, Kinnunen I, Blomster H, et al. Total or subtotal glossectomy with laryngeal preservation: a national study of 29 patients. Eur Arch Otorhinolaryngol. 2018;275:191-197 pubmed publisher
    ..performed in Finland between 2005 and 2014 in terms of overall survival (OS), disease-specific survival (DSS), locoregional control (LRC), and functional outcome as assessed by gastric tube or tracheostomy dependence and ..
  45. Liao S, Yue J. Dimeric Sesquiterpenoids. Prog Chem Org Nat Prod. 2016;101:1-112 pubmed publisher
    ..As dimeric molecules might be able to act on both moieties of a dimeric protein, dimeric sesquiterpenoids (DSs), which are generated biogenetically from coupling of two sesquiterpenoid molecules, are in essence potential ..
  46. Zhou C, Chen F, Zhuang C, Pang W, Zhang F, Huang D, et al. Feasibility of radical gastrectomy for elderly patients with gastric cancer. Eur J Surg Oncol. 2016;42:303-11 pubmed publisher
    ..Both overall survival and disease-specific survival (DSS) rates declined with advancing age...
  47. Liu Z, Tian Y, Liu S, Xu G, Guo M, Lian X, et al. Clinicopathological feature and prognosis of primary hepatic gastrointestinal stromal tumor. Cancer Med. 2016;5:2268-75 pubmed publisher
    ..The 5-year median disease-free survival (DFS) time was 24.0 months and 5-year disease-specific survival (DSS) rate was 33.3%, respectively...
  48. Rubino F, Nathan D, Eckel R, Schauer P, Alberti K, Zimmet P, et al. Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: a Joint Statement by International Diabetes Organizations. Obes Surg. 2017;27:2-21 pubmed publisher
    ..The 2nd Diabetes Surgery Summit (DSS-II), an international consensus conference, was convened in collaboration with leading diabetes organizations to ..
  49. Panpetch W, Chancharoenthana W, Bootdee K, Nilgate S, Finkelman M, Tumwasorn S, et al. Lactobacillus rhamnosus L34 Attenuates Gut Translocation-Induced Bacterial Sepsis in Murine Models of Leaky Gut. Infect Immun. 2018;86: pubmed publisher
    ..pathogenic bacteria with GI leakage induced by either an antibiotic cocktail (ATB) and/or dextran sulfate sodium (DSS)...
  50. Kaur A, Hernández Fernaud J, Del Mar Aguilo Ferretjans M, Wellington E, Christie Oleza J. 100 days of marine Synechococcus - Ruegeria pomeroyi interaction, a detailed analysis of the exoproteome. Environ Microbiol. 2017;: pubmed publisher
    ..WH7803 and the Roseobacter strain Ruegeria pomeroyi DSS-3, both in nutrient-enriched and natural oligotrophic seawater...
  51. Jacobi C, Rauch J, Hagemann J, Lautz T, Reiter M, Baumeister P. Prognostic value of the lymph node ratio in oropharyngeal carcinoma stratified for HPV-status. Eur Arch Otorhinolaryngol. 2018;275:515-524 pubmed publisher
    ..007). Patients with LNR???10% had a significant better overall survival (OS) and disease-specific survival (DSS)...
  52. Heublein S, Mayr D, Meindl A, Angele M, Gallwas J, Jeschke U, et al. Thyroid Hormone Receptors Predict Prognosis in BRCA1 Associated Breast Cancer in Opposing Ways. PLoS ONE. 2015;10:e0127072 pubmed publisher
    ..receptors that bind to estrogen or progesterone, thyroid hormone receptors (TRs) are members of the nuclear hormone receptor superfamily...
  53. Marx J, Jensen J, Seelye S, Walton R, Hankenson F. The Effects of Acute Blood Loss for Diagnostic Bloodwork and Fluid Replacement in Clinically Ill Mice. Comp Med. 2015;65:202-16 pubmed
    ..for diagnostic bloodwork in healthy mice compared with streptozotocin-induced diabetic and dextran sulfate sodium (DSS)-treated dehydrated mice...
  54. Kuales G, Weiss M, Sedelmeier O, Pfeifer D, Arnold S. A Resource for the Transcriptional Signature of Bona Fide Trophoblast Stem Cells and Analysis of Their Embryonic Persistence. Stem Cells Int. 2015;2015:218518 pubmed publisher
  55. Abraham M, Shetty V, McKenzie F, Curran J. X-linked Congenital Adrenal Hypoplasia with a Novel NR0B1/DAX Gene Mutation. Indian Pediatr. 2016;53:529-31 pubmed
    ..Genetic testing identified a novel NR0B1/DAX gene mutation. A genetic diagnosis in children with primary adrenal insufficiency is useful to provide genetic counselling. ..
  56. Vuong H, Kondo T, Duong U, Pham T, Oishi N, Mochizuki K, et al. Prognostic impact of vascular invasion in differentiated thyroid carcinoma: a systematic review and meta-analysis. Eur J Endocrinol. 2017;177:207-216 pubmed publisher
    ..Pooled hazard ratio (HR) for disease-specific survival (DSS) was calculated using random effect model weighted by inverse variance method...
  57. Wu J, McDuffie J, Song J, Harris M, Raymond H, Chen Y, et al. LC/MS/MS Profiling of Tissue Oxysterols and its Application in Dextran Sodium Sulphate Induced Mouse Colitis Models. Curr Top Med Chem. 2017;17:2781-2790 pubmed publisher
    ..The method was applied to a dextran sodium sulphate (DSS)-induced mouse colitis model, which revealed that one particular dihydroxycholesterol (diOHC), 7?,25-diOHC, was ..
  58. Lee V, Chan K. Tumor budding and poorly-differentiated cluster in prognostication in Stage II colon cancer. Pathol Res Pract. 2018;214:402-407 pubmed publisher
    ..Both TB and PDC correlated with 5-year disease-specific survival (DSS) and overall survival (OS) (DSS for TB: 89% (Bd1); 73% (Bd2); 52% (Bd3), p?=?0...
  59. Gao X, Cao Q, Cheng Y, Zhao D, Wang Z, Yang H, et al. Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response. Proc Natl Acad Sci U S A. 2018;115:E2960-E2969 pubmed publisher
    ..Here, we found chronic stress to sensitize mice to dextran sulfate sodium (DSS)-induced colitis; to increase the infiltration of B cells, neutrophils, and proinflammatory ly6Chi ..
  60. Guo W, Burris T, Zhang Y, Huang B, Mason J, Copeland K, et al. Genomic sequence of the DAX1 gene: an orphan nuclear receptor responsible for X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 1996;81:2481-6 pubmed
    The gene responsible for X-linked adrenal hypoplasia congenita, DAX1, encodes a member of the nuclear hormone receptor superfamily. We sequenced 8851 bp that contained the DAX1 genomic region...
  61. Iyer A, Zhang Y, McCabe E. LXXLL motifs and AF-2 domain mediate SHP (NR0B2) homodimerization and DAX1 (NR0B1)-DAX1A heterodimerization. Mol Genet Metab. 2007;92:151-9 pubmed
    ..to Dosage-sensitive sex reversal adrenal hypoplasia congenita (AHC) critical region on the X chromosome, gene 1 (DAX1; NR0B1). Mutations in DAX1 cause AHC with associated hypogonadotropic hypogonadism...
  62. Shukla P, Chaudhry K, Mir H, Gangwar R, Yadav N, Manda B, et al. Chronic ethanol feeding promotes azoxymethane and dextran sulfate sodium-induced colonic tumorigenesis potentially by enhancing mucosal inflammation. BMC Cancer. 2016;16:189 pubmed publisher
    ..We evaluated the effect of chronic ethanol feeding on azoxymethane and dextran sulfate sodium (AOM/DSS)-induced carcinogenesis in mouse colon...
  63. Hiramoto K, Yamate Y, Sato E. The Effects of Ultraviolet Eye Irradiation on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice. Photochem Photobiol. 2016;92:728-34 pubmed publisher
    ..This study examined the action of UVA and UVB on dextran sodium sulfate (DSS)-induced ulcerative colitis...
  64. El Salhy M, Hatlebakk J, Gilja O. Abnormalities in endocrine and immune cells are correlated in dextran?sulfate?sodium?induced colitis in rats. Mol Med Rep. 2017;15:12-20 pubmed publisher
    ..were to elucidate the possible abnormalities in the colonic endocrine cells in rats with dextran sodium sulfate (DSS)?induced colitis, and to determine whether they are correlated with alterations in the immune cells...
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    ..In conclusion, NR0B1 might play a role in the malignant potential of lung adenocarcinoma. ..
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    ..It encodes a protein with large similarity to members of the nuclear hormone receptor superfamily. Several different mutations in this gene have been found in patients suffering from AHC...
  68. Ding P, Li L, Huang T, Yang C, Xu E, Wang N, et al. Complement component 6 deficiency increases susceptibility to dextran sulfate sodium-induced murine colitis. Immunobiology. 2016;221:1293-303 pubmed publisher
    ..blocked due to the absence of C6 to develop an acute colitis model by the administration of dextran sulfate sodium (DSS)...
  69. Lin X, Wang H, Li Y, Yang J, Yang R, Wei D, et al. Functional characterization of CXCR4 in mediating the expression of protein C system in experimental ulcerative colitis. Am J Transl Res. 2017;9:4821-4835 pubmed
    ..The expression of CXCR3, CCR10, and CXCR4 in dextran sulfate sodium (DSS)-induced colitis mouse model was measured by immunohistochemistry and western blot analysis...
  70. Costa L, Mol J, Silva A, Macêdo A, Silva T, Alves G, et al. Iron acquisition pathways and colonization of the inflamed intestine by Salmonella enterica serovar Typhimurium. Int J Med Microbiol. 2016;306:604-610 pubmed publisher
    ..Here we utilized streptomycin-pretreated mice and dextran sodium sulfate (DSS)-treated mice to investigate how pathways for S...
  71. Ehrlund A, Anthonisen E, Gustafsson N, Venteclef N, Robertson Remen K, Damdimopoulos A, et al. E3 ubiquitin ligase RNF31 cooperates with DAX-1 in transcriptional repression of steroidogenesis. Mol Cell Biol. 2009;29:2230-42 pubmed publisher
  72. Hayashi S, Hamada T, Zinsou D, Oshiro M, Itoi K, Yamamoto T, et al. PI3K p85α Subunit-deficient Macrophages Protect Mice from Acute Colitis due to the Enhancement of IL-10 Production. Sci Rep. 2017;7:6187 pubmed publisher
    ..Experimental acute colitis was induced using 3% dextran sulfate sodium (DSS) in drinking water for 7 days...
  73. Tsai W, Tung Y. Novel deletion mutations of the DAX1 (NR0B1) gene in two Taiwanese families with X-linked adrenal hypoplasia congenita. J Pediatr Endocrinol Metab. 2005;18:991-7 pubmed
    To analyze the DAX1 (NROB1) gene in Taiwanese families with adrenal hypoplasia congenita. Two unrelated Taiwanese patients were followed up at our pediatric endocrine clinic. Both patients presented with adrenal crisis...
  74. Tissera H, Rathore A, Leong W, Pike B, Warkentien T, Farouk F, et al. Chymase Level Is a Predictive Biomarker of Dengue Hemorrhagic Fever in Pediatric and Adult Patients. J Infect Dis. 2017;216:1112-1121 pubmed publisher
    ..DF), while few develop the life-threatening diseases dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). No laboratory tests predict DHF or DSS...
  75. Eser M, Ayaz A. Haploinsufficiency of the DMRT Gene Cluster in a Case with 46,XY Ovotesticular Disorder of Sexual Development. Balkan Med J. 2018;35:272-274 pubmed publisher
    ..Single gene mutations in SRY, SOX9, DMRT1 and DAX1 can lead to ovotesticular disorder of sexual development...
  76. Feng S, Dai Z, Liu A, Wang H, Chen J, Luo Z, et al. β-Sitosterol and stigmasterol ameliorate dextran sulfate sodium-induced colitis in mice fed a high fat Western-style diet. Food Funct. 2017;8:4179-4186 pubmed publisher
    ..and compared the effects of stigmasterol and β-sitosterol (both with purities ≥95%) on dextran sulfate sodium (DSS)-induced colitis in C57BL/6J male mice fed a high fat Western-style diet...
  77. Laurenzana E, Chen T, Kannuswamy M, Sell B, Strom S, Li Y, et al. The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3). Mol Pharmacol. 2012;82:918-28 pubmed publisher
    ..The results of this investigation identify DAX-1 as a novel and potent CAR corepressor and suggest that DAX-1 functions as a coordinate hepatic regulator of CAR's biological function. ..
  78. Pedersen E, Juhl P, Wetke R, Andersen T. Speech perception in medico-legal assessment of hearing disabilities. Int J Audiol. 2016;55:547-55 pubmed publisher
    ..The study purposes are: (1) to investigate whether discrimination scores (DSs) relate to patients' subjective experience of their hearing and communication ability (the latter referring to ..
  79. Spoerner M, Karl M, Lopes P, Hoering M, Loeffel K, Nuehs A, et al. High pressure 31P NMR spectroscopy on guanine nucleotides. J Biomol NMR. 2017;67:1-13 pubmed publisher
    ..for GMP, as well as GDP and GTP in absence and presence of Mg2+ ions using indirect referencing to DSS under identical experimental conditions...
  80. Xu X, Feng Y, Yuan W, Huang K, Liang L, Fu J. Novel mutations in DAX1 of X-linked adrenal hypoplasia congenita over several generations in one family. Endocr Pract. 2013;19:e105-11 pubmed publisher
    X-linked adrenal hypoplasia congenital (AHC) is a rare disorder caused by mutations in DAX1 gene...
  81. Sato D, Shimoyamada M, Ito Y, Yoshida S, Ishida H, Yamaguchi T, et al. Reactive swelling of the regional lymph nodes in patients with stage II colorectal cancer as a prognostic factor. Nihon Shokakibyo Gakkai Zasshi. 2017;114:1629-1638 pubmed publisher
    ..Survival analyses of the two groups showed that overall survival (OS) and disease-specific survival (DSS) were longer in the reactive LN swelling group than in the no LN swelling group in patients with total colorectal ..
  82. Bassett J, O Halloran D, Williams G, Beardwell C, Shalet S, Thakker R. Novel DAX1 mutations in X-linked adrenal hypoplasia congenita and hypogonadotrophic hypogonadism. Clin Endocrinol (Oxf). 1999;50:69-75 pubmed
    Mutations of the DAX1 gene (Dosage-sensitive sex reversal-Adrenal hypoplasia congenita critical region on the X chromosome gene 1), which encodes a novel orphan nuclear receptor, have been identified in patients with X-linked adrenal ..
  83. Choi J, Chung K, Jin B, Cheon S, Nugroho A, Roh S, et al. Anti-inflammatory effects of an ethanol extract of Aster glehni via inhibition of NF-?B activation in mice with DSS-induced colitis. Food Funct. 2017;8:2611-2620 pubmed publisher
    ..the underlying molecular mechanism of an ethanol extract of Aster glehni (AG) in mice with dextran sulfate sodium (DSS)-induced colitis...
  84. Zhang Y, Huang B, Anyane Yeboa K, Carvalho J, Clemons R, Cole T, et al. Nine novel mutations in NR0B1 (DAX1) causing adrenal hypoplasia congenita. Hum Mutat. 2001;18:547 pubmed
    ..This gene encodes an orphan member of the nuclear receptor superfamily, DAX1. Ongoing efforts in our laboratory have identified nine novel NR0B1 mutations in X-linked AHC patients (Y81X, ..
  85. Nalbantoglu I, Blanc V, Davidson N. Characterization of Colorectal Cancer Development in Apc (min/+) Mice. Methods Mol Biol. 2016;1422:309-27 pubmed publisher
    ..on C57BL/6J (B6) background, focusing on the roles of environmental modifiers, including Dextran Sulfate Sodium (DSS), high fat diet, and bile acid supplementation in the context of experimental colorectal cancer...
  86. Sünderhauf A, Skibbe K, Preisker S, Ebbert K, Verschoor A, Karsten C, et al. Regulation of epithelial cell expressed C3 in the intestine - Relevance for the pathophysiology of inflammatory bowel disease?. Mol Immunol. 2017;90:227-238 pubmed publisher
    ..In DSS-induced chronic colitis mouse models, C3 mRNA expression was upregulated in colonic biopsies and ileal pIECs with ..
  87. Zepp J, Zhao J, Liu C, Bulek K, Wu L, Chen X, et al. IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis. J Immunol. 2017;199:3849-3857 pubmed publisher
    ..Abrogation of IL-17A signaling in mice attenuated tissue repair of dextran sulfate sodium (DSS)-induced damage in colon epithelium and markedly reduced tumor development in an azoxymethane/DSS model of colitis-..
  88. Baptissart M, Martinot E, Vega A, Sédes L, Rouaisnel B, de Haze A, et al. Bile acid-FXRα pathways regulate male sexual maturation in mice. Oncotarget. 2016;7:19468-82 pubmed publisher
    ..In conclusion, BA-FRXα signaling is a critical actor during sexual maturation. ..
  89. Krych Ł, Kot W, Bendtsen K, Hansen A, Vogensen F, Nielsen D. Have you tried spermine? A rapid and cost-effective method to eliminate dextran sodium sulfate inhibition of PCR and RT-PCR. J Microbiol Methods. 2018;144:1-7 pubmed publisher
    The Dextran Sulfate Sodium (DSS) induced colitis mouse model is commonly used to investigate human inflammatory bowel disease (IBD)...
  90. Chisaki I, Kobayashi M, Itagaki S, Hirano T, Iseki K. Liver X receptor regulates expression of MRP2 but not that of MDR1 and BCRP in the liver. Biochim Biophys Acta. 2009;1788:2396-403 pubmed publisher
    Liver X receptors (LXRs) belong to the nuclear hormone receptor superfamily...
  91. Pylypenko O, Welz T, Tittel J, Kollmar M, Chardon F, Malherbe G, et al. Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes. elife. 2016;5: pubmed publisher
    ..The myosin V globular tail domain (MyoV-GTD) interacts directly with an evolutionarily conserved Spir sequence motif...
  92. Xie Y, Murray Stewart T, Wang Y, Yu F, Li J, Marton L, et al. Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy. J Control Release. 2017;246:110-119 pubmed publisher
    ..The nanoparticles were prepared from a biodegradable polycationic prodrug, named DSS-BEN, which was synthesized from a polyamine analog N1,N11-bisethylnorspermine (BENSpm)...