DAPK1

Summary

Gene Symbol: DAPK1
Description: death associated protein kinase 1
Alias: DAPK, ROCO3, death-associated protein kinase 1, DAP kinase 1
Species: human
Products:     DAPK1

Top Publications

  1. Deiss L, Feinstein E, Berissi H, Cohen O, Kimchi A. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. Genes Dev. 1995;9:15-30 pubmed
    ..Altogether, it is suggested that these two novel genes are candidates for positive mediators of programmed cell death that is induced by IFN-gamma. ..
  2. Li Y, Grupe A, Rowland C, Nowotny P, Kauwe J, Smemo S, et al. DAPK1 variants are associated with Alzheimer's disease and allele-specific expression. Hum Mol Genet. 2006;15:2560-8 pubmed
    ..nucleotide polymorphisms (SNPs) on chromosome 9 and identified two SNPs in the death-associated protein kinase, DAPK1, that show significant association with LOAD...
  3. Craig A, Chrystal J, Fraser J, Sphyris N, Lin Y, Harrison B, et al. The MDM2 ubiquitination signal in the DNA-binding domain of p53 forms a docking site for calcium calmodulin kinase superfamily members. Mol Cell Biol. 2007;27:3542-55 pubmed
    ..assay was used to identify a broad range of calcium calmodulin kinase superfamily members, including CHK2, CHK1, DAPK-1, DAPK-3, DRAK-1, and AMPK, as Ser(20) kinases...
  4. Leung R, Liu S, Chan K, Tam K, Chan K, Wong L, et al. Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer. Oncol Rep. 2008;19:1339-45 pubmed
    This study was aimed at investigating the death-associated protein kinase (DAPK) promoter methylation and its clinical relevance in cervical cancer...
  5. McNamara L, Watterson D, Brunzelle J. Structural insight into nucleotide recognition by human death-associated protein kinase. Acta Crystallogr D Biol Crystallogr. 2009;65:241-8 pubmed publisher
    Death-associated protein kinase (DAPK) is a member of the Ca(2+)/calmodulin-regulated family of serine/threonine protein kinases...
  6. de Diego I, Kuper J, Bakalova N, Kursula P, Wilmanns M. Molecular basis of the death-associated protein kinase-calcium/calmodulin regulator complex. Sci Signal. 2010;3:ra6 pubmed publisher
    Death-associated protein kinase (DAPK) provides a model for calcium-bound calmodulin (CaM)-dependent protein kinases (CaMKs)...
  7. Wu P, Tsai P, Chen G, Chou H, Huang Y, Chen Y, et al. DAPK activates MARK1/2 to regulate microtubule assembly, neuronal differentiation, and tau toxicity. Cell Death Differ. 2011;18:1507-20 pubmed publisher
    Death-associated protein kinase (DAPK) is a key player in several modes of neuronal death/injury and has been implicated in the late-onset Alzheimer's disease (AD)...
  8. Ye M, Li D, Zhou F, Guo Q, Xia B. Epigenetic regulation of death-associated protein kinase expression in primary gastric cancers from Chinese patients. Eur J Cancer Prev. 2012;21:241-6 pubmed publisher
    Death-associated protein kinase (DAPK) is a novel serine/threonine kinase involved in apoptosis and tumor suppression...
  9. Sun L, Cao D, Yang J, Li H, Zhou X, Song Z, et al. Population-based case-control study on DAPK1, RAR-?2 and MGMT methylation in liquid-based cytology. Arch Gynecol Obstet. 2012;285:1433-9 pubmed publisher
    ..The aim of this study was to investigate: (1) the promoter methylation status of DAPK1, RAR-?2 and MGMT in randomly selected normal cytology of the general female population; (2) the effectiveness of ..

More Information

Publications104 found, 100 shown here

  1. Bialik S, Kimchi A. The death-associated protein kinases: structure, function, and beyond. Annu Rev Biochem. 2006;75:189-210 pubmed
    Death-associated protein kinase (DAPk) is the founding member of a newly classified family of Ser/Thr kinases, whose members not only possess significant homology in their catalytic domains, but also share cell death-associated functions...
  2. Liu Y, Gao W, Siegfried J, Weissfeld J, Luketich J, Keohavong P. Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokers. BMC Cancer. 2007;7:74 pubmed
    ..promoter methylation in the ras-association domain isoform A (RASSF1A) and the death-associated protein kinase (DAPK) genes in lung tumors from patients with primarily non-small cell lung cancer (NSCLC) from the Western Pennsylvania ..
  3. Eisenberg Lerner A, Kimchi A. DAP kinase regulates JNK signaling by binding and activating protein kinase D under oxidative stress. Cell Death Differ. 2007;14:1908-15 pubmed
    The stress-activated kinase JNK mediates key cellular responses to oxidative stress. Here we show that DAP kinase (DAPk), a cell death promoting Ser/Thr protein kinase, plays a main role in oxidative stress-induced JNK signaling...
  4. Zhao X, Meng Z, Qiao Y, Zhang H. [Promoter methylation of DAPK gene in cervical carcinoma]. Ai Zheng. 2008;27:919-23 pubmed
    ..This study was to explore the relationship between the promoter methylation and inactivation of DAPK gene in cervical cancer...
  5. Zalckvar E, Berissi H, Mizrachy L, Idelchuk Y, Koren I, Eisenstein M, et al. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep. 2009;10:285-92 pubmed publisher
    ..Here, we show that death-associated protein kinase (DAPK) regulates this process. The activated form of DAPK triggers autophagy in a beclin-1-dependent manner...
  6. Zalckvar E, Berissi H, Eisenstein M, Kimchi A. Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL. Autophagy. 2009;5:720-2 pubmed
    ..We recently revealed a novel phosphorylation-based mechanism by which death-associated protein kinase (DAPk) regulates this process...
  7. Michie A, McCaig A, Nakagawa R, Vukovic M. Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer. FEBS J. 2010;277:74-80 pubmed publisher
    Death-associated protein kinase (DAPK) is a pro-apoptotic serine/threonine protein kinase that is dysregulated in a wide variety of cancers...
  8. Sugita H, Iida S, Inokuchi M, Kato K, Ishiguro M, Ishikawa T, et al. Methylation of BNIP3 and DAPK indicates lower response to chemotherapy and poor prognosis in gastric cancer. Oncol Rep. 2011;25:513-8 pubmed publisher
    ..genes, Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) and death-associated protein kinase (DAPK), on the response to chemotherapy in metastatic or recurrent gastric cancers...
  9. Hu S, Kong X, Cheng Z, Sun Y, Shen G, Xu W, et al. Promoter methylation of p16, Runx3, DAPK and CHFR genes is frequent in gastric carcinoma. Tumori. 2010;96:726-33 pubmed
    ..In this study, we determined the promoter hypermethylation status and mRNA expression of 4 genes: p16, Runx3, DAPK and CHFR.
  10. Lee T, Chen C, Suizu F, Huang P, Schiene Fischer C, Daum S, et al. Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function. Mol Cell. 2011;42:147-59 pubmed publisher
    ..Here, we identify death-associated protein kinase 1 (DAPK1), a known tumor suppressor, as a kinase responsible for phosphorylation of Pin1 on Ser71 in the catalytic active ..
  11. Wei Q, Claus R, Hielscher T, Mertens D, Raval A, Oakes C, et al. Germline allele-specific expression of DAPK1 in chronic lymphocytic leukemia. PLoS ONE. 2013;8:e55261 pubmed publisher
    ..1-6531) that resulted in allele-specific expression (ASE) of death-associated protein kinase 1 (DAPK1) and predisposition to chronic lymphocytic leukemia (CLL)...
  12. Kristensen L, Treppendahl M, Asmar F, Girkov M, Nielsen H, Kjeldsen T, et al. Investigation of MGMT and DAPK1 methylation patterns in diffuse large B-cell lymphoma using allelic MSP-pyrosequencing. Sci Rep. 2013;3:2789 pubmed publisher
    The tumor suppressor genes MGMT and DAPK1 become methylated in several cancers including diffuse large B-cell lymphoma (DLBCL). However, allelic methylation patterns have not been investigated in DLBCL...
  13. Inbal B, Shani G, Cohen O, Kissil J, Kimchi A. Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis. Mol Cell Biol. 2000;20:1044-54 pubmed
    ..Possible functional connections between DAP kinase and DRP-1 are discussed. ..
  14. Kawaguchi K, Oda Y, Saito T, Yamamoto H, Takahira T, Tamiya S, et al. Death-associated protein kinase (DAP kinase) alteration in soft tissue leiomyosarcoma: Promoter methylation or homozygous deletion is associated with a loss of DAP kinase expression. Hum Pathol. 2004;35:1266-71 pubmed
    ..Furthermore, although further detailed analyses are necessary, promoter methylation or homozygous deletion status of DAP kinase may present a major alternative mechanism of a loss of or decrease in DAP kinase expression. ..
  15. Raval A, Tanner S, Byrd J, Angerman E, Perko J, Chen S, et al. Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell. 2007;129:879-90 pubmed
    ..We show that loss or reduced expression of death-associated protein kinase 1 (DAPK1) underlies cases of heritable predisposition to CLL and the majority of sporadic CLL...
  16. Niyazi M, Liu X, Zhu K. [Death-associated protein kinase promoter (DAPK) hypermethylation in uterine cervical cancer and intraepithelial neoplasia in Uyghur nationality women]. Zhonghua Zhong Liu Za Zhi. 2012;34:31-4 pubmed
    To investigate the methylation levels of death-associated protein kinase (DAPK) in Uyghur female patients with different cervical lesions in Xinjiang, and to discuss the relationship of the expression and significance of DAPK in normal ..
  17. Ottini L, Rizzolo P, Siniscalchi E, Zijno A, Silvestri V, Crebelli R, et al. Gene promoter methylation and DNA repair capacity in monozygotic twins with discordant smoking habits. Mutat Res Genet Toxicol Environ Mutagen. 2015;779:57-64 pubmed publisher
    ..of ten genes involved in cell cycle control, differentiation, apoptosis and DNA repair (p16, FHIT, RAR, CDH1, DAPK1, hTERT, RASSF1A, MGMT, BRCA1 and PALB2) was assessed in the same batches of cells isolated for previous studies, ..
  18. Yang Q, Mas A, Diamond M, Al Hendy A. The Mechanism and Function of Epigenetics in Uterine Leiomyoma Development. Reprod Sci. 2016;23:163-75 pubmed publisher
    ..deleted in lung and esophageal cancer 1 (DLEC1), keratin 19 (KRT19), and death-associated protein kinase 1 (DAPK1) also display higher hypermethylation levels in leiomyomas when compared to adjacent normal tissues...
  19. Chen K, Stephen J, Havard S, Mahan M, Divine G, Worsham M. IGSF4 methylation as an independent marker of human papillomavirus-positive oropharyngeal squamous cell carcinoma. JAMA Otolaryngol Head Neck Surg. 2015;141:257-63 pubmed publisher
    ..Aberrant promoter methylation of IGSF4, DAPK1, and ESR1 genes, known to be methylated in head and neck squamous cell carcinoma, including OPSCC, was examined by ..
  20. Ren J, Chu Y, Ma H, Zhang Y, Zhang X, Zhao D, et al. Epigenetic interventions increase the radiation sensitivity of cancer cells. Curr Pharm Des. 2014;20:1857-65 pubmed
    ..The genes expression of the p53, RASSF1, and DAPK gene families was increased by 5-aza-CdR, which induces G2-M phase arrest and increased apoptosis...
  21. Lopes F, Keita A, Saxena A, Reyes J, Mancini N, Al Rajabi A, et al. ER-stress mobilization of death-associated protein kinase-1-dependent xenophagy counteracts mitochondria stress-induced epithelial barrier dysfunction. J Biol Chem. 2018;293:3073-3087 pubmed publisher
    ..dextran sodium sulfate (DSS) or DNP and co-treated with DAPK6, an inhibitor of death-associated protein kinase 1 (DAPK1). Contrary to our hypothesis, induction of ER stress (i.e...
  22. Hearnden V, Powers H, Elmogassabi A, Lowe R, Murdoch C. Methyl-donor depletion of head and neck cancer cells in vitro establishes a less aggressive tumour cell phenotype. Eur J Nutr. 2018;57:1321-1332 pubmed publisher
    ..depletion on enzymes controlling DNA methylation and the pro-apoptotic factors death-associated protein kinase-1 (DAPK1) and p53 upregulated modulator of apoptosis (PUMA) were examined by quantitative-PCR or immunoblotting...
  23. Arif A, Yao P, Terenzi F, Jia J, Ray P, Fox P. The GAIT translational control system. Wiley Interdiscip Rev RNA. 2017;: pubmed publisher
    ..Subsequently, the DAPK-ZIPK kinase axis phosphorylates L13a, inducing release from the 60S ribosomal subunit and binding to GAPDH...
  24. Nakaoka T, Saito Y, Saito H. Aberrant DNA Methylation as a Biomarker and a Therapeutic Target of Cholangiocarcinoma. Int J Mol Sci. 2017;18: pubmed publisher
    ..and microRNAs (miRNAs) including MLH1, p14, p16, death-associated protein kinase (DAPK), miR-370 and miR-376c are frequently methylated in cholangiocarcinoma...
  25. Vares G, Wang B, Ishii Ohba H, Nenoi M, Nakajima T. Diet-induced obesity modulates epigenetic responses to ionizing radiation in mice. PLoS ONE. 2014;9:e106277 pubmed publisher
    ..Using MSP, we observed that the promoters of p16 and Dapk genes were methylated in the livers of C57BL/6J mice fed a HF diet (irradiated and non-irradiated); Mgmt promoter ..
  26. Pehlivan S, Artac M, Sever T, Bozcuk H, Kilincarslan C, Pehlivan M. Gene methylation of SFRP2, P16, DAPK1, HIC1, and MGMT and KRAS mutations in sporadic colorectal cancer. Cancer Genet Cytogenet. 2010;201:128-32 pubmed publisher
    The aim of this study was to investigate the methylation of the SFRP2, P16, DAPK1, HIC1, and MGMT genes, as well as the mutation of amino acid codons 12 and 13 of the KRAS gene in normal and tumor tissue DNA of patients diagnosed with ..
  27. Kalantari M, Osann K, Calleja Macias I, Kim S, Yan B, Jordan S, et al. Methylation of human papillomavirus 16, 18, 31, and 45 L2 and L1 genes and the cellular DAPK gene: Considerations for use as biomarkers of the progression of cervical neoplasia. Virology. 2014;448:314-21 pubmed publisher
    ..type and pathology and measured the overall methylation of informative amplicons of HPV late genes and the cellular DAPK gene...
  28. Dhiab M, Ziadi S, Mestiri S, Gacem R, Ksiaa F, Trimeche M. DNA methylation patterns in EBV-positive and EBV-negative Hodgkin lymphomas. Cell Oncol (Dordr). 2015;38:453-62 pubmed publisher
    ..3 % for P16, 58.5 % for RASSF1A, 50.9 % for CDH1, 45.3 % for DAPK, 43.4 % for GSTP1, 37.7 % for SHP1 and 24.3 % for MGMT...
  29. Kameshima S, Okada M, Yamawaki H. Expression and localization of calmodulin-related proteins in brain, heart and kidney from spontaneously hypertensive rats. Biochem Biophys Res Commun. 2016;469:654-8 pubmed publisher
    ..proteins including eukaryotic elongation factor 2 kinase (eEF2K), death-associated protein kinase (DAPK)3, and histone deacetylase (HDAC)4 was specifically elevated in mesenteric artery from spontaneously hypertensive ..
  30. Zhao W, Meng F, Lai Y, Peng Z, Ma J. [Effect of DAPK overexpression on biological behaviors and caspase-3 expression in HL-60 cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2016;36:729-32 pubmed
    To explore the effect of DAPK overexpression on the biological behaviors and caspase-3 expression in HL-60 cells. The expression of DAPK mRNA was detected by RT-PCR leukemia cell lines K562, Molt4, U937, and HL-60 cells...
  31. Su Y, Xu H, Xu Y, Yu J, Xian Y, Luo Q. Azacytidine inhibits the proliferation of human promyelocytic leukemia cells (HL60) by demethylation of MGMT, DAPK and p16 genes. Hematology. 2012;17:41-6 pubmed publisher
    ..to detect gene methylation status changes and expression levels of p16, Death associated protein kinase (DAPK) and O(6)-methylguanine-DNA methyltransferase (MGMT) before and after treatment with azacytidine...
  32. Li Y, Zhu M, Zhang X, Cheng D, Ma X. Clinical significance of DAPK promoter hypermethylation in lung cancer: a meta-analysis. Drug Des Devel Ther. 2015;9:1785-96 pubmed publisher
    Death-associated protein kinase 1 (DAPK) is an important serine/threonine kinase involved in various cellular processes, including apoptosis, autophagy, and inflammation...
  33. Duan D, Chai G, Ni Z, Hu Y, Luo Y, Cheng X, et al. Phosphorylation of tau by death-associated protein kinase 1 antagonizes the kinase-induced cell apoptosis. J Alzheimers Dis. 2013;37:795-808 pubmed publisher
    ..for the cell death induced by constitutively expressed factors, such as death-associated protein kinase 1 (DAPK1). We found that DAPK1 was upregulated and accumulated in the brain of human tau transgenic mice...
  34. Mitsui Y, Chang I, Fukuhara S, Hiraki M, Arichi N, Yasumoto H, et al. CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma. BMC Cancer. 2015;15:942 pubmed publisher
    ..found that these anti-tumor effects on RCC cells caused by CYP1B1 depletion may be due to alteration of CDC20 and DAPK1 expression based on gene microarray and confirmed by real-time PCR...
  35. Jayaprakash C, Varghese V, Bellampalli R, Radhakrishnan R, Ray S, Kabekkodu S, et al. Hypermethylation of Death-Associated Protein Kinase (DAPK1) and its association with oral carcinogenesis - An experimental and meta-analysis study. Arch Oral Biol. 2017;80:117-129 pubmed publisher
    The value of abnormal DNA methylation of DAPK1 promoter and its association with various cancers have been suggested in the literature...
  36. De Schutter H, Geeraerts H, Verbeken E, Nuyts S. Promoter methylation of TIMP3 and CDH1 predicts better outcome in head and neck squamous cell carcinoma treated by radiotherapy only. Oncol Rep. 2009;21:507-13 pubmed
    ..current study aimed to evaluate the incidence and prognostic value of the promoter hypermethylation of TIMP3, CDH1, DAPK, RASSF1A, p16INK4A and MGMT in HNSCC treated solely by radiotherapy...
  37. Kim B, You M, Chen C, Suh J, Tanzi R, Ho Lee T. Inhibition of death-associated protein kinase 1 attenuates the phosphorylation and amyloidogenic processing of amyloid precursor protein. Hum Mol Genet. 2016;25:2498-2513 pubmed
    ..While death-associated protein kinase 1 (DAPK1) is highly expressed in AD brains and its genetic variants are linked to AD risk, little is known about the impact ..
  38. Chuang M, Hsiao T, Tong A, Xu S, Chisholm A. DAPK interacts with Patronin and the microtubule cytoskeleton in epidermal development and wound repair. elife. 2016;5: pubmed publisher
    ..In C. elegans, death-associated protein kinase (DAPK-1) regulates epidermal morphogenesis, innate immunity and wound repair...
  39. Chuang Y, Fang L, Lin Feng M, Chen R, Lai M. The tumor suppressor death-associated protein kinase targets to TCR-stimulated NF-kappa B activation. J Immunol. 2008;180:3238-49 pubmed
    Death-associated protein kinase (DAPK) is a unique multidomain kinase acting both as a tumor suppressor and an apoptosis inducer...
  40. Tanaka T, Bai T, Yukawa K. Specific downregulation of death-associated protein kinase enhances Fas-mediated apoptosis in the human differentiated endometrial adenocarcinoma cell line, HHUA. Eur J Gynaecol Oncol. 2011;32:293-6 pubmed
    Death-associated protein kinase (DAPK) is a serine/threonine kinase that is well-known as a positive mediator of Fas-mediated apoptosis. Previous reports have shown that DAPK and Fas are expressed in human endometrial adenocarcinoma cells...
  41. Singh A, Sharma N. Identification of key pathways and genes with aberrant methylation in prostate cancer using bioinformatics analysis. Onco Targets Ther. 2017;10:4925-4933 pubmed publisher
    ..The top hub genes AR, CDH13, CDKN2A, DAPK1, GSTP1, CD44 and RASSF1 identified from protein-protein interaction network construction ..
  42. Chen W, Hung W, Kang W, Huang Y, Chai C. Urothelial carcinomas arising in arsenic-contaminated areas are associated with hypermethylation of the gene promoter of the death-associated protein kinase. Histopathology. 2007;51:785-92 pubmed
    ..The aim was to determine whether hypermethylation of death-associated protein kinase (DAPK) gene is associated with chronic arsenic exposure...
  43. Bialik S, Kimchi A. Lethal weapons: DAP-kinase, autophagy and cell death: DAP-kinase regulates autophagy. Curr Opin Cell Biol. 2010;22:199-205 pubmed publisher
    ..This review will summarize the functional and mechanistic studies that have linked DAP-kinase to the regulation of autophagy in general, and autophagic cell death, in particular. ..
  44. Umman B, Cakmakoglu B, Cincin Z, Kocaaga M, Emet S, Tamer S, et al. Identification of gene variants related to the nitric oxide pathway in patients with acute coronary syndrome. Gene. 2015;574:76-81 pubmed publisher
    ..As a result, death-associated protein kinase 3 (DAPK) (rs10426955) was found to be most statistically significant SNP...
  45. Feinstein E, Druck T, Kastury K, Berissi H, Goodart S, Overhauser J, et al. Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively. Genomics. 1995;29:305-7 pubmed
  46. Uesato S, Matsuura Y, Matsue S, Sumiyoshi T, Hirata Y, Takemoto S, et al. Discovery of new low-molecular-weight p53-Mdmx disruptors and their anti-cancer activities. Bioorg Med Chem. 2016;24:1919-26 pubmed publisher
    ..respectively, by using a Flag-p53 and glutathione S-transferase (GST)-fused protein complex (Mdm2, Mdmx, DAPK1, or PPID)...
  47. Shang T, Joseph J, Hillard C, Kalyanaraman B. Death-associated protein kinase as a sensor of mitochondrial membrane potential: role of lysosome in mitochondrial toxin-induced cell death. J Biol Chem. 2005;280:34644-53 pubmed
    We have investigated here the mechanism of dephosphorylation and activation of death-associated protein kinase (DAPK) and the role of lysosome in neuroblastoma cells (SH-SY5Y) treated with mitochondrial toxins, such as MPP(+) and rotenone...
  48. Gade P, Manjegowda S, Nallar S, Maachani U, Cross A, Kalvakolanu D. Regulation of the death-associated protein kinase 1 expression and autophagy via ATF6 requires apoptosis signal-regulating kinase 1. Mol Cell Biol. 2014;34:4033-48 pubmed publisher
    The death-associated protein kinase 1 (DAPK1) is an important regulator of cell death and autophagy...
  49. Hilton B, Li Z, Musich P, Wang H, Cartwright B, SERRANO M, et al. ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1. Mol Cell. 2015;60:35-46 pubmed publisher
    ..However, UV inactivates Pin1 via DAPK1, stabilizing the pro-survival cis-isomeric ATR...
  50. Wang S, Shi X, Li H, Pang P, Pei L, Shen H, et al. DAPK1 Signaling Pathways in Stroke: from Mechanisms to Therapies. Mol Neurobiol. 2017;54:4716-4722 pubmed publisher
    Death-associated protein kinase 1 (DAPK1), a Ca2+/calmodulin (CaM)-dependent serine/threonine protein kinase, plays important roles in diverse apoptosis pathways not only in tumor suppression but also in neuronal cell death...
  51. Maslikowski B, Wang L, Wu Y, Fielding B, Bédard P. JunD/AP-1 Antagonizes the Induction of DAPK1 To Promote the Survival of v-Src-Transformed Cells. J Virol. 2017;91: pubmed publisher
    ..One gene in particular, death-associated protein kinase 1 (DAPK1), is a C/EBPβ-regulated mediator of apoptosis in gamma interferon (IFN-γ)-induced cell death...
  52. Pronina I, Loginov V, Burdennyy A, Fridman M, Senchenko V, Kazubskaya T, et al. DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression. Gene. 2017;604:1-8 pubmed publisher
    ..analysis between expression levels of the 13 miRNAs and 5 cancer-associated genes, namely RASSF1(A), CHL1, APAF1, DAPK1, and BCL2, which were predicted as targets for these miRNAs, to investigate the impact of these miRNAs on these ..
  53. Xiong W, Wu Y, Xian W, Song L, Hu L, Pan S, et al. DAPK1-ERK signal mediates oxygen glucose deprivation reperfusion induced apoptosis in mouse N2a cells. J Neurol Sci. 2018;387:210-219 pubmed publisher
    Death-associated protein kinase 1 (DAPK1) is a kinase found to promote neuronal apoptosis induced by ischemia. Extracellular signal-regulated kinase (ERK) was identified as a key molecule in DAPK1 signaling...
  54. Lee C, Leu S, Tzeng R, Wang S, Tsai S, Sun K, et al. Latent membrane protein 1 of Epstein-Barr virus regulates death-associated protein kinase 1 in lymphoblastoid cell line. Virology. 2011;413:19-25 pubmed publisher
    ..We observed death-associated protein kinase 1 (DAPK1) upregulation in B cells following EBV infection and high DAPK1 levels in LCLs...
  55. Millares L, Serra M, Andreo F, Sanz Santos J, Montón C, Grimau C, et al. Assessment of methylation status of locoregional lymph nodes in lung cancer using EBUS-NA. Clin Exp Metastasis. 2015;32:637-46 pubmed publisher
    ..To establish the relationship between methylation status of p16, DAPK, RASSF1a, APC and CDH13 genes in lymph nodes sampled by EBUS-NA, tumor staging and prognosis...
  56. Maejima Y, Isobe M, Sadoshima J. Regulation of autophagy by Beclin 1 in the heart. J Mol Cell Cardiol. 2016;95:19-25 pubmed publisher
    ..autophagy activity has been shown to be both positively and negatively regulated by various kinases, including DAPK, ROCK1, Mst1 and JNK1, in response to external stimuli...
  57. Wijetunga N, Belbin T, Burk R, Whitney K, Abadi M, Greally J, et al. Novel epigenetic changes in CDKN2A are associated with progression of cervical intraepithelial neoplasia. Gynecol Oncol. 2016;142:566-73 pubmed publisher
    ..CIN3 and invasive cervical cancer, assaying 120 CpG dinucleotide sites spanning APC, CDH1, CDH13, CDKN2A, CDKN2B, DAPK1, FHIT, GSTP1, HIC1, MGMT, MLH1, RARB, RASSF1, TERT and TIMP3 using the Illumina Infinium array...
  58. Steinmann S, Scheibe K, Erlenbach Wuensch K, Neufert C, Schneider Stock R. Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review). Int J Oncol. 2015;47:5-15 pubmed publisher
    The cytoskeleton-associated serine/threonine kinase death-associated protein kinase (DAPK) has been described as a cancer gene chameleon with functional antagonistic duality in a cell type and context specific manner...
  59. Shanmugam R, Gade P, Wilson Weekes A, Sayar H, Suvannasankha A, Goswami C, et al. A noncanonical Flt3ITD/NF-?B signaling pathway represses DAPK1 in acute myeloid leukemia. Clin Cancer Res. 2012;18:360-369 pubmed publisher
    Death-associated protein kinase 1 (DAPK1), a tumor suppressor, is a rate-limiting effector in an endoplasmic reticulum (ER) stress-dependent apoptotic pathway. Its expression is epigenetically suppressed in several tumors...
  60. Chang C, Yang M, Lin B, Chen S, Pan S, Hsiao M, et al. CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation. Cell Death Differ. 2013;20:443-55 pubmed publisher
  61. Zhang J, Hu M, Shu H, Li S. Death-associated protein kinase 1 is an IRF3/7-interacting protein that is involved in the cellular antiviral immune response. Cell Mol Immunol. 2014;11:245-52 pubmed publisher
    ..Here, we identified death-associated protein kinase 1 (DAPK1) as an IRF7-interacting protein by tandem affinity purification (TAP)...
  62. Soria J, Rodriguez M, Liu D, Lee J, Hong W, Mao L. Aberrant promoter methylation of multiple genes in bronchial brush samples from former cigarette smokers. Cancer Res. 2002;62:351-5 pubmed
    ..in early lung tumorigenesis, we analyzed promoter methylation status of the p16, death-associated protein kinase (DAPK) and glutathione S-transferase P1 (GSTP1) genes using methylation-specific PCR in bronchial brush samples obtained ..
  63. Jin Y, Gallagher P. Antisense depletion of death-associated protein kinase promotes apoptosis. J Biol Chem. 2003;278:51587-93 pubmed
    Death-associated protein kinases (DAPK) are serine/threonine protein kinases that have an important role in regulating cell death...
  64. Chan A, Chan M, Lee T, Ng E, Leung W, Lau J, et al. Promoter hypermethylation of Death-associated protein-kinase gene associated with advance stage gastric cancer. Oncol Rep. 2005;13:937-41 pubmed
    ..041), advance stage of disease (p=0.029) and a poorer event-free survival (log-rank test p=0.0141). DAP-kinase promoter methylation as a potential prognostic marker for gastric cancer patients deserved further evaluation. ..
  65. Zhang L, Nephew K, Gallagher P. Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes. J Biol Chem. 2007;282:11795-804 pubmed
    Death-associated protein kinase (DAPK) has been found associated with HSP90, and inhibition of HSP90 with 17-alkylamino-17-demethoxygeldanamycin reduced expression of DAPK...
  66. Nayak C, Carvalho A, Jeronimo C, Henrique R, Kim M, Hoque M, et al. Positive correlation of tissue inhibitor of metalloproteinase-3 and death-associated protein kinase hypermethylation in head and neck squamous cell carcinoma. Laryngoscope. 2007;117:1376-80 pubmed
    ..if TIMP-3 promoter was hypermethylated in HNSCC, if there was any correlation with death associated protein kinase (DAPK), a tumor suppressor whose promoter has been hypermethylated at high levels in HNSCC, and if any clinical factors ..
  67. Fujita Y, Taniguchi J, Uchikawa M, Endo M, Hata K, Kubo T, et al. Neogenin regulates neuronal survival through DAP kinase. Cell Death Differ. 2008;15:1593-608 pubmed publisher
    ..Here, we show that the serine/threonine kinase death-associated protein kinase (DAPK) is involved in the signal transduction of neogenin...
  68. Pulling L, Grimes M, DAMIANI L, Juri D, Do K, Tellez C, et al. Dual promoter regulation of death-associated protein kinase gene leads to differentially silenced transcripts by methylation in cancer. Carcinogenesis. 2009;30:2023-30 pubmed publisher
    Death-associated protein kinase (DAPK), a mediator of apoptotic systems, is silenced by promoter hypermethylation in lung and breast tumors...
  69. Widau R, Jin Y, Dixon S, Wadzinski B, Gallagher P. Protein phosphatase 2A (PP2A) holoenzymes regulate death-associated protein kinase (DAPK) in ceramide-induced anoikis. J Biol Chem. 2010;285:13827-38 pubmed publisher
    The tumor suppressor, death-associated protein kinase (DAPK), is a Ca(2+)/calmodulin-regulated Ser/Thr kinase with an important role in regulating cytoskeletal dynamics...
  70. Lee Y, Yuan W, Ho H, Chen C, Shih H, Chen R. The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses. EMBO J. 2010;29:1748-61 pubmed publisher
    Death-associated protein kinase (DAPK) was identified as a mediator of interferon (IFN)-induced cell death. How IFN controls DAPK activation remains largely unknown...
  71. Wu Z, Zhang W, Yu J, Zhang Q, Tian Y, Lu R, et al. Association of DAPK1 genetic variations with Alzheimer's disease in Han Chinese. Brain Res. 2011;1374:129-33 pubmed publisher
    ..Death-associated kinase protein 1 (DAPK1), which participates in the process of cell death, has attracted people's attention for its potential risk with ..
  72. Claus R, Hackanson B, Poetsch A, Zucknick M, Sonnet M, Blagitko Dorfs N, et al. Quantitative analyses of DAPK1 methylation in AML and MDS. Int J Cancer. 2012;131:E138-42 pubmed publisher
    Aberrant DNA methylation and concomitant transcriptional silencing of death-associated protein kinase 1 (DAPK1) have been demonstrated to be key pathogenic events in chronic lymphocytic leukemia (CLL)...
  73. Eisenberg Lerner A, Kimchi A. PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk. Cell Death Differ. 2012;19:788-97 pubmed publisher
    ..Our findings show that both the tumor-suppressor death-associated protein kinase (DAPk) and protein kinase D (PKD), which we previously showed to be phosphorylated and consequently activated by DAPk, ..
  74. Dai L, Ma C, Zhang Z, Zeng S, Liu A, Tang S, et al. DAPK Promoter Methylation and Bladder Cancer Risk: A Systematic Review and Meta-Analysis. PLoS ONE. 2016;11:e0167228 pubmed publisher
    ..Several studies demonstrate a potential association between the Death-Associated Protein Kinase (DAPK) gene promoter methylation and bladder cancer risk, tumor stage and histological grade...
  75. Liu W, Yang H, Hsu C, Wang C, Wang T, Kao J, et al. Pegylated IFN-α suppresses hepatitis C virus by promoting the DAPK-mTOR pathway. Proc Natl Acad Sci U S A. 2016;113:14799-14804 pubmed publisher
    Death-associated protein kinase (DAPK) has been found to be induced by IFN, but its antiviral activity remains elusive...
  76. Yuan W, Chen J, Shu Y, Liu S, Wu L, Ji J, et al. Correlation of DAPK1 methylation and the risk of gastrointestinal cancer: A systematic review and meta-analysis. PLoS ONE. 2017;12:e0184959 pubmed publisher
    One of the critical mechanisms of gastrointestinal cancer pathogenesis is the silencing of death associated protein kinase 1 (DAPK1), which could be caused by aberrant methylation of the promoter...
  77. Jin Y, Blue E, Dixon S, Hou L, Wysolmerski R, Gallagher P. Identification of a new form of death-associated protein kinase that promotes cell survival. J Biol Chem. 2001;276:39667-78 pubmed
    In this study, two alternatively spliced forms of the mouse death-associated protein kinase (DAPK) have been identified and their roles in apoptosis examined...
  78. Wang W, Kuo J, Yao C, Chen R. DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals. J Cell Biol. 2002;159:169-79 pubmed
    ..Our results indicate that DAP-kinase exerts apoptotic effects by suppressing integrin functions and integrin-mediated survival signals, thereby activating a p53-dependent apoptotic pathway. ..
  79. Burch L, Scott M, Pohler E, Meek D, Hupp T. Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1. J Mol Biol. 2004;337:115-28 pubmed
    ..One peptide that bound MDM2 had significant homology to members of the death-activated protein kinase (DAPK) family, an enzyme family of no known direct link to the p53 pathway...
  80. Qian J, Yao D, Lin J, Wang Y, Han L, Xu W, et al. Methylation of DAPK1 promoter: frequent but not an adverse prognostic factor in myelodysplastic syndrome. Int J Lab Hematol. 2010;32:74-81 pubmed publisher
    ..In this study, the methylation status of death-associated protein kinase 1 (DAPK1) gene promoter was analyzed by using methylation-specific polymerase chain reaction in bone marrow (BM) samples ..
  81. Lin Q, Geng J, Ma K, Yu J, Sun J, Shen Z, et al. RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China. J Cancer Res Clin Oncol. 2009;135:1675-84 pubmed publisher
    ..The methylated state of p16INK4A, ESR1, HOX9, RASSF1A, DAPK1, PTEN, ABCB1, MGMT, APC and MT1G genes that have been reported frequently methylated in lung cancer was determined ..
  82. Ahmed I, Pusch C, Hamed T, Rashad H, Idris A, El Fadle A, et al. Epigenetic alterations by methylation of RASSF1A and DAPK1 promoter sequences in mammary carcinoma detected in extracellular tumor DNA. Cancer Genet Cytogenet. 2010;199:96-100 pubmed publisher
    ..nonmethylated genes: RAS association domain family member 1A (RASSF1A) and death-associated protein kinase 1 (DAPK1) in 26 patients with breast cancer, 16 patients with benign breast diseases, and 12 age-matched healthy controls...
  83. Wu X, Liu W, Tian Y, Xiao M, Wu Y, Li C. Aberrant methylation of death-associated protein kinase 1 CpG islands in myelodysplastic syndromes. Acta Haematol. 2011;125:179-85 pubmed publisher
    Death-associated protein kinase 1 (DAPK1), a proapoptotic serine/threonine kinase, is a candidate tumor suppressor gene...
  84. Dachsel J, Wider C, Vilariño Güell C, Aasly J, Rajput A, Rajput A, et al. Death-associated protein kinase 1 variation and Parkinson's disease. Eur J Neurol. 2011;18:1090-3 pubmed publisher
    ..The Lrrk2 protein is a member of the ROCO family, which also includes Lrrk1 and Dapk1. Functional genetic variants of the DAPK1 gene (rs4877365 and rs4878104) have been previously associated with ..
  85. Kiyotani K, Uno S, Mushiroda T, Takahashi A, Kubo M, Mitsuhata N, et al. A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy. Pharmacogenet Genomics. 2012;22:229-35 pubmed publisher
    ..We identified four loci possibly associated with gemcitabine-induced leukopenia/neutropenia [rs11141915 in DAPK1 on chromosome 9q21, combined P=1.27×10, odds ratio (OR)=4.10; rs1901440 on chromosome 2q12, combined P=3...
  86. Chung C, Tsai H, Tsai C, Chen W, Lieu A, Wang C, et al. Differential hypermethylation of death-associated protein kinase promoter in central neurocytoma and oligodendroglioma. Biomed Res Int. 2014;2014:506458 pubmed publisher
    ..Death-associated protein kinase (DAPK) is a calcium/calmodulin-regulated serine/threonine protein kinase involved in many apoptosis pathways, and ..
  87. Kaur M, Singh A, Singh K, Gupta S, Sachan M. Development of a multiplex MethyLight assay for the detection of DAPK1 and SOX1 methylation in epithelial ovarian cancer in a north Indian population. Genes Genet Syst. 2016;91:175-181 pubmed
    ..011), whereas this difference between cancer and normal samples was not significant for DAPK1 promoter methylation (P = 0...
  88. Tian X, Shi Y, Liu N, Yan Y, Li T, Hua P, et al. Upregulation of DAPK contributes to homocysteine-induced endothelial apoptosis via the modulation of Bcl2/Bax and activation of caspase 3. Mol Med Rep. 2016;14:4173-4179 pubmed publisher
    ..The present study investigated whether death-associated protein kinase (DAPK) is involved in Hcy?induced apoptosis in human umbilical vein endothelial cells (HUVECs)...
  89. Deng C, Chen S, Jiang M, Nilupar T, Wang H, Hao J. [Prognostic Value of Multigene Methylation in Patients with Myelodysplastic Syndrome]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:1118-1122 pubmed publisher
    To analyze the methylation status of p15, DAPK, SOCS1 and FHIT genes in patients with myelodysplastic syndrome(MDS) and to explore the prognostic significance of gene methylation...
  90. Tian J, Das S, Sheng Z. Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18. J Biol Chem. 2003;278:26265-74 pubmed
    ..Our results suggest that syntaxin is a DAP kinase substrate and provide a novel signal transduction pathway by which syntaxin function could be regulated in response to intracellular [Ca2+] and synaptic activity. ..
  91. Lin Y, Stevens C, Hrstka R, Harrison B, Fourtouna A, Pathuri S, et al. An alternative transcript from the death-associated protein kinase 1 locus encoding a small protein selectively mediates membrane blebbing. FEBS J. 2008;275:2574-84 pubmed publisher
    Death-associated protein kinase 1 (DAPK-1) is a multidomain protein kinase with diverse roles in autophagic, apoptotic and survival pathways...
  92. Kilinc D, Ozdemir O, Ozdemir S, Korgali E, Koksal B, Uslu A, et al. Alterations in promoter methylation status of tumor suppressor HIC1, SFRP2, and DAPK1 genes in prostate carcinomas. DNA Cell Biol. 2012;31:826-32 pubmed publisher
    ..for promoter methylation status of TS hypermethylated in cancer 1 (HIC1), death-associated protein kinase 1 (DAPK1), secreted frizzled-related protein 2 (SFRP2), cyclin-dependent kinase inhibitor 2A (p16), and O-6-methylguanine-..