DAMAGE

Summary

Gene Symbol: DAMAGE
Description: MAGE family member E1
Alias: DAMAGE, HCA1, melanoma-associated antigen E1, MAGE-E1 antigen, alpha-dystrobrevin-associated MAGE Protein, dystrobrevin-associated MAGE protein, hepatocellular carcinoma-associated HCA1, hepatocellular carcinoma-associated protein 1, melanoma antigen family E, 1, melanoma antigen family E1
Species: human
Products:     DAMAGE

Top Publications

  1. Rados J, Jerković Gulin S, Dotlic S, Basic Kinda S, Ceović R. Folliculotropic Mycosis Fungoides Associated with Autoimmune Hepatitis. Acta Dermatovenerol Croat. 2017;25:248-250 pubmed
    ..Before death, he suffered from candidiasis and toxic liver damage due to fluconazole...
  2. Henning R, Bourgeois M, Harbison R. Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders. Cardiovasc Toxicol. 2018;18:493-506 pubmed publisher
    Poly(ADP-ribosyl)ation is an immediate cellular repair response to DNA damage and is catalyzed primarily by poly(ADP-ribose)polymerase-1 (PARP1), which is the most abundant of the 18 different PARP isoforms and accounts for more than 90% ..
  3. Kaliyaperumal K, Grove J, Delahay R, Griffiths W, Duckworth A, Aithal G. Pharmacogenomics of drug-induced liver injury (DILI): Molecular biology to clinical applications. J Hepatol. 2018;69:948-957 pubmed publisher
    ..We will also discuss ongoing areas of uncertainty. ..
  4. Shikov A, Pozharitskaya O, Makarov V. Aralia elata var. mandshurica (Rupr. & Maxim.) J.Wen: An overview of pharmacological studies. Phytomedicine. 2016;23:1409-1421 pubmed publisher
    ..Its proposed ability to moderate stress-induced damage and dysfunction in the cardiovascular tissue might make Aralia the adaptogen of choice among patients with higher ..
  5. Jarius S, Kleiter I, Ruprecht K, Asgari N, Pitarokoili K, Borisow N, et al. MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 3: Brainstem involvement - frequency, presentation and outcome. J Neuroinflammation. 2016;13:281 pubmed
    ..MRI or laboratory signs of blood-brain barrier damage were present in 5/12...
  6. Tutar Y. miRNA and cancer; computational and experimental approaches. Curr Pharm Biotechnol. 2014;15:429 pubmed
    ..Vasconcelos showed that overexpression of miR-128 decreased acute myeloid leukemia cells and increased the DNA damage. Laryngeal squamous cell carcinoma is the largest subgroup of squamous cell carcinoma in head and neck. And Dr...
  7. Roy S, Esmaeilniakooshkghazi A, Patnaik S, Wang Y, George S, Ahrorov A, et al. Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation. Gastroenterology. 2018;154:1405-1420.e2 pubmed publisher
    ..Overexpression of IRGM1 (or IRGM) induced cell death by necroptosis, accompanied by release of damage-associated molecular patterns (DAMPs)...
  8. Pacak K. Phaeochromocytoma: a catecholamine and oxidative stress disorder. Endocr Regul. 2011;45:65-90 pubmed
    ..due to metabolic oxidative stress results in proto-oncogene activation, tumor suppressor gene inactivation, DNA damage, and genomic instability...
  9. Dong L, Han X, Tao X, Xu L, Xu Y, Fang L, et al. Protection by the Total Flavonoids from Rosa laevigata Michx Fruit against Lipopolysaccharide-Induced Liver Injury in Mice via Modulation of FXR Signaling. Foods. 2018;7: pubmed publisher
    ..of the total flavonoids (TFs) from Rosa laevigata Michx fruit against carbon tetrachloride-induced liver damage, non-alcoholic fatty liver disease, and liver ischemia-reperfusion injury...

More Information

Publications158 found, 100 shown here

  1. Sil R, Ray D, Chakraborti A. Glycyrrhizin ameliorates metabolic syndrome-induced liver damage in experimental rat model. Mol Cell Biochem. 2015;409:177-89 pubmed publisher
    ..objective of this study is to investigate the effect of glycyrrhizin treatment on metabolic syndrome-induced liver damage. After induction of metabolic syndrome in rats by high fructose (60%) diet for 6 weeks, the rats were treated with ..
  2. Bleecker M. Carbon monoxide intoxication. Handb Clin Neurol. 2015;131:191-203 pubmed publisher
    ..has a short half-life, examination of other biomarkers of CO neurotoxicity that reflect inflammation or neuronal damage has not demonstrated consistent results...
  3. Khushboo M, Murthy M, Devi M, Sanjeev S, Ibrahim K, Kumar N, et al. Testicular toxicity and sperm quality following copper exposure in Wistar albino rats: ameliorative potentials of L-carnitine. Environ Sci Pollut Res Int. 2018;25:1837-1862 pubmed publisher
    ..along with degenerative characteristics, accentuated germ cell depletion in the seminiferous epithelium, severe damage of spermatogonia and Sertoli cells (73...
  4. Mazzio E, Lewis C, Soliman K. Transcriptomic Profiling of MDA-MB-231 Cells Exposed to Boswellia Serrata and 3-O-Acetyl-B-Boswellic Acid; ER/UPR Mediated Programmed Cell Death. Cancer Genomics Proteomics. 2017;14:409-425 pubmed
    ..key components PERK (EIF2AK3), XBP1, C/EBP homologous protein transcription factor (CHOP), ATF3 and DDIT3,4/DNA-damage-inducible transcript 3,4 (GADD34)...
  5. Pall M, Levine S. Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors. Sheng Li Xue Bao. 2015;67:1-18 pubmed
    ..and/or humans including various cardiovascular diseases, kidney diseases, lung diseases, diseases of toxic liver damage, cancer (prevention), diabetes/metabolic syndrome/obesity, sepsis, autoimmune diseases, inflammatory bowel disease,..
  6. da Rosa M, João Ribeiro C, Seminotti B, Teixeira Ribeiro R, Amaral A, Coelho D, et al. In vivo intracerebral administration of L-2-hydroxyglutaric acid provokes oxidative stress and histopathological alterations in striatum and cerebellum of adolescent rats. Free Radic Biol Med. 2015;83:201-13 pubmed publisher
    ..From the biochemical and histological findings, it is presumed that L-2-HG provokes striatal and cerebellar damage in vivo possibly through oxidative stress induction...
  7. Valko M, Jomova K, Rhodes C, Kuča K, Musílek K. Redox- and non-redox-metal-induced formation of free radicals and their role in human disease. Arch Toxicol. 2016;90:1-37 pubmed publisher
    ..Fenton reaction, which produces hydroxyl radicals), and reactive nitrogen species, RNS, which may cause oxidative damage to biological macromolecules such as DNA, proteins and lipids...
  8. Li S, Feng L, Jiang W, Liu Y, Jiang J, Wu P, et al. Deficiency of dietary niacin impaired gill immunity and antioxidant capacity, and changes its tight junction proteins via regulating NF-?B, TOR, Nrf2 and MLCK signaling pathways in young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2016;55:212-22 pubmed publisher
    ..deficiency decreased lysozyme and acid phosphatase activities, and complement 3 content, and caused oxidative damage that might be partly due to the decreased copper, zinc superoxide dismutase, catalase, glutathione reductase, ..
  9. Lugea A, Gerloff A, Su H, Xu Z, Go A, Hu C, et al. The Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells. Gastroenterology. 2017;153:1674-1686 pubmed publisher
    ..translation initiation factor 2 alpha kinase 3 (EIF2AK3, also called PERK) and increased protein levels of DNA damage inducible transcript 3 (DDIT3, also called CHOP). CHOP regulates transcription to promote apoptosis...
  10. Salas Huetos A, Bullo M, Salas Salvado J. Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies. Hum Reprod Update. 2017;23:371-389 pubmed publisher
    ..and retrospective studies in which fertile/infertile men were well defined (men with sperm disorders, sperm DNA damage, varicocele or idiopathic infertility). The primary outcomes were semen quality or fecundability...
  11. Yu H, Wang D, Zou L, Zhang Z, Xu H, Zhu F, et al. Proteomic alterations of brain subcellular organelles caused by low-dose copper exposure: implication for Alzheimer's disease. Arch Toxicol. 2018;92:1363-1382 pubmed publisher
    ..decreased ATP content, increased the positive staining of 8-hydroxyguanosine (8-OHdG), a marker of DNA oxidative damage, and caused apoptosis and a decrease in synaptic proteins...
  12. Ansari R, Husain K, Rizvi S. Role of Transcription Factors in Steatohepatitis and Hypertension after Ethanol: The Epicenter of Metabolism. Biomolecules. 2016;6: pubmed publisher
    Chronic alcohol consumption induces multi-organ damage, including alcoholic liver disease (ALD), pancreatitis and hypertension. Ethanol and ethanol metabolic products play a significant role in the manifestation of its toxicity...
  13. Li X, Wang P, Yu C, Yan X, Yin J. [Clinical application of ultrasound guided Fogarty balloon catheter in arterial crisis]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017;31:1220-1224 pubmed publisher
    ..myonephropathic metabolic syndrome and corrected after hemodialysis; 1 case suffered from acute liver functional damage and corrected by comprehensive treatment of internal medicine...
  14. Candeias E, Duarte A, Sebastião I, Fernandes M, Placido A, Carvalho C, et al. Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology. Mol Neurobiol. 2017;54:6471-6489 pubmed publisher
    ..These may ultimately delay the deleterious AD-like brain changes (including oxidative damage to lipids and DNA, amyloidogenic processing of amyloid precursor protein and increased tau protein phosphorylation)..
  15. Elmallah M, Elkhadragy M, Al Olayan E, Abdel Moneim A. Protective Effect of Fragaria ananassa Crude Extract on Cadmium-Induced Lipid Peroxidation, Antioxidant Enzymes Suppression, and Apoptosis in Rat Testes. Int J Mol Sci. 2017;18: pubmed publisher
    ..and elevated levels of reactive oxygen species (ROS) have recently been reported to be the main cause of cellular damage as a result of cadmium exposure...
  16. Pan F, Feng L, Jiang W, Jiang J, Wu P, Kuang S, et al. Methionine hydroxy analogue enhanced fish immunity via modulation of NF-?B, TOR, MLCK, MAPKs and Nrf2 signaling in young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2016;56:208-228 pubmed publisher
    ..glutathione contents, antioxidant enzymes activities and corresponding isoforms mRNA levels to attenuate oxidative damage, which might be to the up-regulation of NF-E2-related factor 2 mRNA levels and down-regulation of Kelch-like ECH-..
  17. Yun S, Han Y, Lee J, Kim S, Lee S. Enhanced Susceptibility to 5-Fluorouracil in Human Colon Cancer Cells by Silencing of GRP78. Anticancer Res. 2017;37:2975-2984 pubmed
    ..GRP78 is thought to protect against tissue or organ damage under pathological conditions, such as neurotoxic stress, myocardial infarction, or arteriosclerosis...
  18. Sobinoff A, Sutherland J, Beckett E, Stanger S, Johnson R, Jarnicki A, et al. Damaging legacy: maternal cigarette smoking has long-term consequences for male offspring fertility. Hum Reprod. 2014;29:2719-35 pubmed publisher
    ..Spermatogenesis was examined using testicular histology and apoptosis/DNA damage was assessed using caspase immunohistochemistry and TUNEL...
  19. Chen L, Feng L, Jiang W, Jiang J, Wu P, Zhao J, et al. Dietary riboflavin deficiency decreases immunity and antioxidant capacity, and changes tight junction proteins and related signaling molecules mRNA expression in the gills of young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2015;45:307-20 pubmed publisher
    ..05). Moreover, riboflavin deficiency caused oxidative damage, which might be partly due to decrease copper, zinc superoxide dismutase, catalase, glutathione reductase, ..
  20. Banerjee S, Aykin Burns N, Krager K, Shah S, Melnyk S, Hauer Jensen M, et al. Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction. Free Radic Biol Med. 2016;99:296-307 pubmed publisher
    ..enhancer binding protein delta (Cebpd, C/EBPδ) has been implicated in the regulation of oxidative stress, DNA damage response, genomic stability and inflammation...
  21. Wang Y, Sun Y, Huang Z, Wang P, Feng W, Li J, et al. Associations of urinary metal levels with serum hormones, spermatozoa apoptosis and sperm DNA damage in a Chinese population. Environ Int. 2016;94:177-188 pubmed publisher
    ..environmental exposure to metals contributes to reproductive hormone changes, spermatozoa apoptosis and sperm DNA damage in a Chinese population...
  22. Yan J, Ai G, Zhang X, Xu H, Huang Z. Investigations of the total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic against α-naphthylisothiocyanate-induced cholestatic liver injury in rats. J Ethnopharmacol. 2015;172:202-13 pubmed publisher
    ..have investigated the hepatoprotective effects of the TFA against carbon tetrachloride (CCl4) induced hepatocyte damage in vitro and liver injury in vivo...
  23. Rizvi T, Batchala P, Mukherjee S. Brain Death: Diagnosis and Imaging Techniques. Semin Ultrasound CT MR. 2018;39:515-529 pubmed publisher
    ..Thus, a radiologist can play a critical role by recognizing the initial extensive hypoxic or ischemic damage to the central nervous system including the brainstem on imaging; guiding a neurologist evaluating a potential BD, ..
  24. Shah N, Khan M, Nigussie D. Phytochemical investigation and nephroprotective potential of Sida cordata in rat. BMC Complement Altern Med. 2017;17:388 pubmed publisher
    ..Histopathological observations, total protein contents, lipid peroxidation, DNA damage and relative weight were also analyzed...
  25. Chang C, Ortiz K, Ansari A, Gershwin M. The Zika outbreak of the 21st century. J Autoimmun. 2016;68:1-13 pubmed publisher
    ..In pregnant women, fetal neurological complications include brain damage and microcephaly, while in adults there have been several cases of virus-associated Guillain-Barre syndrome...
  26. Peng H, Zhu Q, Zhong S, Levy D. Transcription of the Human Microsomal Epoxide Hydrolase Gene (EPHX1) Is Regulated by PARP-1 and Histone H1.2. Association with Sodium-Dependent Bile Acid Transport. PLoS ONE. 2015;10:e0125318 pubmed publisher
    ..observed in the Old Order Amish population that present numerous hypercholanemic subjects in the absence of liver damage suggesting a defect in bile acid transport into the hepatocyte...
  27. Alluri H, Anasooya Shaji C, Davis M, Tharakan B. Oxygen-glucose deprivation and reoxygenation as an in vitro ischemia-reperfusion injury model for studying blood-brain barrier dysfunction. J Vis Exp. 2015;:e52699 pubmed publisher
    ..Oxidative and metabolic stress following inflammation triggers secondary brain damage including BBB permeability and disruption of tight junction (TJ) integrity...
  28. Bason C, Pagnini I, Brucato A, Maestroni S, Puccetti A, Lunardi C, et al. Congenital heart block and immune mediated sensorineural hearing loss: possible cross reactivity of immune response. Lupus. 2017;26:835-840 pubmed publisher
    ..antibodies in pregnant women cross the placenta and reach the fetal tissues inducing an immune-mediated damage of the cardiac conduction system...
  29. Wu Y, Zhang F, Ma J, Zhang X, Wu L, Qu B, et al. Association of large intergenic noncoding RNA expression with disease activity and organ damage in systemic lupus erythematosus. Arthritis Res Ther. 2015;17:131 pubmed publisher
    ..mononuclear cells (PBMCs) of patients with SLE and correlate these lincRNA levels with disease activity, organ damage, clinical features and medical therapies...
  30. Luxardi G, Reid B, Ferreira F, Maillard P, Zhao M. Measurement of extracellular ion fluxes using the ion-selective self-referencing microelectrode technique. J Vis Exp. 2015;:e52782 pubmed publisher
    ..These properties play crucial roles in maintaining tissue physiology and act as signaling cues after damage, during repair, or under pathological condition...
  31. Zhang H, Huang C, Wang Y, Lu Z, Zhuang N, Zhao D, et al. Hepatitis B Virus X Protein Sensitizes TRAIL-Induced Hepatocyte Apoptosis by Inhibiting the E3 Ubiquitin Ligase A20. PLoS ONE. 2015;10:e0127329 pubmed publisher
    Hepatitis B virus (HBV) infection causes hepatocyte death and liver damage, which may eventually lead to cirrhosis and liver cancer...
  32. Toomey C, Kelly U, Saban D, Bowes Rickman C. Regulation of age-related macular degeneration-like pathology by complement factor H. Proc Natl Acad Sci U S A. 2015;112:E3040-9 pubmed publisher
    ..Interestingly and despite sub-RPE deposit formation occurring in both Cfh(+/-) and Cfh(-/-) mice, RPE damage accompanied by loss of vision occurred only in old Cfh(+/-) mice...
  33. Boucas J, Fritz C, Schmitt A, Riabinska A, Thelen L, Peifer M, et al. Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression. PLoS ONE. 2015;10:e0125745 pubmed publisher
    ..known RBPs like Srsf1, Srsf2, Elavl1 in the genotoxic stress response, we add a new collection of RBPs to the DNA damage response...
  34. Kim H, Lee H, Lee G, Jang H, Kim S, Yoon H, et al. Phospholipase A2 inhibits cisplatin-induced acute kidney injury by modulating regulatory T cells by the CD206 mannose receptor. Kidney Int. 2015;88:550-9 pubmed publisher
    ..PLA2-injected mice showed reduced levels of serum creatinine, blood urea nitrogen, renal tissue damage, and pro-inflammatory cytokine production upon cisplatin administration...
  35. Hernández Aguilera A, Sepúlveda J, Rodríguez Gallego E, Guirro M, García Heredia A, Cabré N, et al. Immunohistochemical analysis of paraoxonases and chemokines in arteries of patients with peripheral artery disease. Int J Mol Sci. 2015;16:11323-38 pubmed publisher
    Oxidative damage to lipids and lipoproteins is implicated in the development of atherosclerotic vascular diseases, including peripheral artery disease (PAD)...
  36. Roome R, Vanderluit J. Paw-dragging: a novel, sensitive analysis of the mouse cylinder test. J Vis Exp. 2015;:e52701 pubmed publisher
    The cylinder test is routinely used to predict focal ischemic damage to the forelimb motor cortex in rodents...
  37. Zheng D, Ma J, Yu Y, Li M, Ni R, Wang G, et al. Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice. Diabetologia. 2015;58:1949-58 pubmed publisher
    ..and improves coronary blood flow and myocardial function in diabetes, at least in part by reducing oxidative damage, inhibiting apoptosis and promoting angiogenesis...
  38. Zhou H, Gao S, Duan X, Liang S, Scott D, Lamont R, et al. Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure. FASEB J. 2015;29:3737-49 pubmed publisher
    ..in a murine endotoxin model, in which we found that SGK1 inhibition aggravates the severity of multiple organ damage and enhances the inflammatory response by heightening both proinflammatory cytokine levels and neutrophil ..
  39. Sá K, Pires Neto O, Santana B, Gomes S, Amoras E, Conde S, et al. Toll-like receptor 3 gene polymorphisms are not associated with the risk of hepatitis B and hepatitis C virus infection. Rev Soc Bras Med Trop. 2015;48:136-42 pubmed publisher
    ..absence of an association between the polymorphisms investigated and susceptibility to HBV and HCV infection; however, these polymorphisms might be associated with a greater degree of biliary damage during the course of HCV infection.
  40. Musso C, Alvarez Gregori J, Jáuregui J, Núñez J. Are currently GFR estimating equations and standard Kt/V value adequate for advanced chronic kidney disease (CKD) frail elderly patients?. Int Urol Nephrol. 2015;47:1231-2 pubmed publisher
    ..patients have a reduced glomerular filtration rate (GFR) due to the combination of ageing and chronic nephropathy damage. This situation is very important to be taken into account in order to prescribe an adequate medication and ..
  41. Bosco A, Romero C, Ambati B, Vetter M. In vivo dynamics of retinal microglial activation during neurodegeneration: confocal ophthalmoscopic imaging and cell morphometry in mouse glaucoma. J Vis Exp. 2015;:e52731 pubmed publisher
    Microglia, which are CNS-resident neuroimmune cells, transform their morphology and size in response to CNS damage, switching to an activated state with distinct functions and gene expression profiles...
  42. Nam Y, Hong B, Rodriguez I, Ji M, Kim K, Kim U, et al. Synergistic Potentials of Coffee on Injured Pancreatic Islets and Insulin Action via KATP Channel Blocking in Zebrafish. J Agric Food Chem. 2015;63:5612-21 pubmed publisher
    ..006). Treatment with TRG and CGA rescued PI damage, and the combination of TRG/CGA had a synergistic effect...
  43. Soutello A, Rodrigues R, Jannuzzi F, São João T, Martinix G, Nadruz W, et al. Quality of Life on Arterial Hypertension: Validity of Known Groups of MINICHAL. Arq Bras Cardiol. 2015;104:299-307 pubmed publisher
    ..regarding the classification of risk for cardiovascular events, symptoms, severity of dyspnea and target-organ damage. Data of 200 hypertensive outpatients concerning sociodemographic and clinical information and health-related ..
  44. Li Y, Deng H, Lv L, Zhang C, Qian L, Xiao J, et al. The miR-193a-3p-regulated ING5 gene activates the DNA damage response pathway and inhibits multi-chemoresistance in bladder cancer. Oncotarget. 2015;6:10195-206 pubmed
    ..siRNA-mediated inhibition of ING5 increased the chemoresistance and inhibited the DNA damage response pathway in 5637 cells...
  45. McSweeney C, Mao Y. Applying stereotactic injection technique to study genetic effects on animal behaviors. J Vis Exp. 2015;:e52653 pubmed publisher
    ..can either overexpress or knockdown gene expression in a relatively focused region without significant damage to the brain tissue...
  46. Wook Yoo S, Han C, Shin J, Won Seo S, Na D, Kaiser M, et al. A Network Flow-based Analysis of Cognitive Reserve in Normal Ageing and Alzheimer's Disease. Sci Rep. 2015;5:10057 pubmed publisher
    ..abundant pathways connecting any two brain regions, providing better compensation or resilience after brain damage. Accordingly, patients with high education levels show more deterioration in structural brain connectivity than ..
  47. Masuda Y, Takahashi H, Sato S, Tomomori Sato C, Saraf A, Washburn M, et al. TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin. Nat Commun. 2015;6:7299 pubmed publisher
    ..that a member of the tripartite motif protein family, TRIM29, is a histone-binding protein responsible for DNA damage response (DDR)...
  48. Goswami P, Gupta S, Joshi N, Sharma S, Singh S. Astrocyte activation and neurotoxicity: A study in different rat brain regions and in rat C6 astroglial cells. Environ Toxicol Pharmacol. 2015;40:122-39 pubmed publisher
    ..oxygen species, augmented nitrite level, impaired mitochondrial activity, apoptotic chromatin condensation and DNA damage in comparison to control cells...
  49. Wu C, Seo E, Klauck S, Efferth T. Cryptotanshinone deregulates unfolded protein response and eukaryotic initiation factor signaling in acute lymphoblastic leukemia cells. Phytomedicine. 2016;23:174-80 pubmed publisher
    ..CPT regulated genes related to UPR and eIF2 signaling pathways. The DNA-Damage-Inducible Transcript 3 (DDIT3) gene, which is activated as consequence of UPR malfunction during apoptosis, was ..
  50. Lin K, Li M, Hsieh K, Kuo H, Cheng M, Sheu J, et al. Impact of Extracorporeal Membrane Oxygenation on Acute Fulminant Myocarditis-related Hemodynamic Compromise Arrhythmia in Children. Pediatr neonatol. 2016;57:480-487 pubmed publisher
    ..New episodes of VT were common (overall occurrence rate, 83%). Although myocardial damage and dysfunction were more severe in Group A, the time to rhythm recovery in this group was shorter than that in ..
  51. Blakely P, Huber A, Irani D. Type-1 angiotensin receptor signaling in central nervous system myeloid cells is pathogenic during fatal alphavirus encephalitis in mice. J Neuroinflammation. 2016;13:196 pubmed publisher
    ..Nox subunits in the CNS, while drug treatment inhibited local Nox activity, ROS production, and oxidative neuronal damage. Telmisartan proved ineffective in Nox-deficient mice, demonstrating that this enzyme is its main target in this ..
  52. Song X, Wang R, Zhao W, Sun S, Zhao C. A facile approach towards amino-coated polyethersulfone particles for the removal of toxins. J Colloid Interface Sci. 2017;485:39-50 pubmed publisher
    The removal of toxins is important due to the damage to aquatic environment...
  53. Nuyen B, Weinreb R, Robbins S. Steroid-induced glaucoma in the pediatric population. J AAPOS. 2017;21:1-6 pubmed publisher
    Steroid medications may cause elevation of intraocular pressure, sometimes with permanent damage to the optic nerve...
  54. Nye G, Sakellariou G, Degens H, Lightfoot A. Muscling in on mitochondrial sexual dimorphism; role of mitochondrial dimorphism in skeletal muscle health and disease. Clin Sci (Lond). 2017;131:1919-1922 pubmed publisher
    ..with males; in contrast, human studies demonstrate no sex difference in mitochondrial bioenergetics and oxidative damage. These divergent observations highlight the importance of considering models and methods used to examine ..
  55. Davoodi I, Rahimi R, Abdollahi M, Farzaei F, Farzaei M, Memariani Z, et al. Promising effect of Rosa damascena extract on high-fat diet-induced nonalcoholic fatty liver. J Tradit Complement Med. 2017;7:508-514 pubmed publisher
    ..damascena dietary supplementation has a therapeutic effect in NAFLD. Improvement of oxidative stress associated damage in liver tissue is among the main pharmacological mechanisms involved in therapeutic activity of the plant.
  56. Feldkamp M, Frank A, Kennedy J, Patrone J, Vangamudi B, Waterson A, et al. Surface reengineering of RPA70N enables cocrystallization with an inhibitor of the replication protein A interaction motif of ATR interacting protein. Biochemistry. 2013;52:6515-24 pubmed publisher
    ..interacts via a basic cleft with a wide range of DNA processing proteins, including several that regulate DNA damage response and repair...
  57. Mukherjee P, Winkler C, Taylor K, Woods T, Nair V, Khan B, et al. SARM1, Not MyD88, Mediates TLR7/TLR9-Induced Apoptosis in Neurons. J Immunol. 2015;195:4913-21 pubmed publisher
    ..TLRs are stimulated both by pathogen-associated molecular patterns as well as by damage-associated molecular patterns, including microRNAs released by damaged neurons...
  58. Fu Y, Huebner J, Kraus V, Griffin T. Effect of Aging on Adipose Tissue Inflammation in the Knee Joints of F344BN Rats. J Gerontol A Biol Sci Med Sci. 2016;71:1131-40 pubmed publisher
    ..size was positively associated with synovial thickness independent of age whereas associations with cartilage damage were age dependent...
  59. Morelli M, Amantini C, Nabissi M, Cardinali C, Santoni M, Bernardini G, et al. Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner. Oncotarget. 2017;8:3380-3395 pubmed publisher
    ..Herein we demonstrated that the TKI axitinib induces DNA damage response (DDR) characterized by γ-H2AX phosphorylation and Chk1 kinase activation leading to G2/M cell cycle ..
  60. Montorfano M, Pla F, Vera L, Cardillo O, Nigra S, Montorfano L. Point-of-care ultrasound and Doppler ultrasound evaluation of vascular injuries in penetrating and blunt trauma. Crit Ultrasound J. 2017;9:5 pubmed publisher
    ..While patients with hard signs of arterial damage must be sent immediately to surgical exploration, when there are soft signs or no clear signs of vascular injury ..
  61. Dresch R, Dresch M, Biegelmeyer R, Argenta D, da Rocha R, Teixeira H, et al. Potential use of secondary products of the agri-food industry for topical formulations and comparative analysis of antioxidant activity of grape leaf polyphenols. Nat Prod Res. 2018;32:486-492 pubmed publisher
    ..using Vitis waste by-products, for use as a topical formulation for skin protection against ultraviolet radiation damage. The study also evaluates the free radical scavenger activity of the crude extracts of dried leaves of Vitis ..
  62. Murillo A, Mullens B. A review of the biology, ecology, and control of the northern fowl mite, Ornithonyssus sylviarum (Acari: Macronyssidae). Vet Parasitol. 2017;246:30-37 pubmed publisher
    ..Economic damage is incurred by direct blood feeding and activation of the of host's immune responses...
  63. Lin S, Li Y, Zamyatnin A, Werner J, Bazhin A. Reactive Oxygen Species and Colorectal Cancer. J Cell Physiol. 2017;: pubmed publisher
    ..In general, moderate level of ROS leads to cell damage, DNA mutation and inflammation, which promotes the initiation and development of cancer...
  64. Vázquez Arreguín K, Maddox J, Kang J, Park D, Cano R, Factor R, et al. BRCA1 through Its E3 Ligase Activity Regulates the Transcription Factor Oct1 and Carbohydrate Metabolism. Mol Cancer Res. 2018;16:439-452 pubmed publisher
    The tumor suppressor BRCA1 regulates the DNA damage response (DDR) and other processes that remain incompletely defined. Among these, BRCA1 heterodimerizes with BARD1 to ubiquitylate targets via its N-terminal E3 ligase activity...
  65. Hassan H, Edrees G, El Gamel E, El Sayed E. Proanthocyanidin and fish oil potent activity against cisplatin-induced renal cell cycle arrest and apoptosis in rats. Ren Fail. 2015;37:1356-62 pubmed publisher
    ..and fish oil (FO: 5 mL/kg/day) against cisplatin-induced nephrotoxicity was evaluated in terms of DNA damage, histopathological changes and expression levels of molecular markers of apoptosis...
  66. Brunet T, Arendt D. From damage response to action potentials: early evolution of neural and contractile modules in stem eukaryotes. Philos Trans R Soc Lond B Biol Sci. 2016;371:20150043 pubmed publisher
    ..These gave rise to mechanosensory receptor cells, neurons and muscle cells by division of labour and can be regarded as the founder cell type of the nervous system. ..
  67. Yamada Y, Miyamoto T, Kashima H, Kobara H, Asaka R, Ando H, et al. Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant. Free Radic Res. 2016;50:414-25 pubmed publisher
    ..we herein examined the roles of LCN2 in the regulation of intracellular iron concentrations, oxidative stress, DNA damage, and antioxidative functions using LCN2-overexpressing (ES2), and LCN2-silenced (RMG-1) CCC cell lines...
  68. Chien S, Huang C, Tsai C, Wang S, Lin Y, Tang C. Interleukin-1β induces fibroblast growth factor 2 expression and subsequently promotes endothelial progenitor cell angiogenesis in chondrocytes. Clin Sci (Lond). 2016;130:667-81 pubmed publisher
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