DAL 1

Summary

Gene Symbol: DAL 1
Description: erythrocyte membrane protein band 4.1 like 3
Alias: 4.1B, DAL-1, DAL1, band 4.1-like protein 3, differentially expressed in adenocarcinoma of the lung protein 1
Species: human
Products:     DAL 1

Top Publications

  1. Charboneau A, Singh V, Yu T, Newsham I. Suppression of growth and increased cellular attachment after expression of DAL-1 in MCF-7 breast cancer cells. Int J Cancer. 2002;100:181-8 pubmed
    ..This is the first evidence that the DAL-1 protein functions at the interface between cell adhesion and apoptosis in controlling cell growth. ..
  2. Yageta M, Kuramochi M, Masuda M, Fukami T, Fukuhara H, Maruyama T, et al. Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer. Cancer Res. 2002;62:5129-33 pubmed
    ..These findings, together with frequent loss of their expression in lung cancers, suggest that TSLC1 and DAL-1 play a critical role in the same pathway involved in the suppression of lung tumor formation and metastasis. ..
  3. Singh V, Miranda T, Jiang W, Frankel A, Roemer M, Robb V, et al. DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo. Oncogene. 2004;23:7761-71 pubmed
    ..1B protein significantly inhibits PRMT3 methylation of cellular substrates. These findings suggest that modulation of post-translational methylation may be an important mechanism through which DAL-1/4.1B affects tumor cell growth. ..
  4. Heller G, Geradts J, Ziegler B, Newsham I, Filipits M, Markis Ritzinger E, et al. Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer. Breast Cancer Res Treat. 2007;103:283-91 pubmed
    ..011, P = 0.02). Our findings suggest that TSLC1 and DAL-1 are involved in the pathogenesis of breast cancer and are frequently inactivated by methylation. ..
  5. Kang Q, Wang T, Zhang H, Mohandas N, An X. A Golgi-associated protein 4.1B variant is required for assimilation of proteins in the membrane. J Cell Sci. 2009;122:1091-9 pubmed publisher
    ..Thus, this newly identified Golgi-specific protein 4.1 appears to have an essential role in maintaining the structure of the Golgi and in assembly of a subset of membrane proteins. ..
  6. Yamada D, Kikuchi S, Williams Y, Sakurai Yageta M, Masuda M, Maruyama T, et al. Promoter hypermethylation of the potential tumor suppressor DAL-1/4.1B gene in renal clear cell carcinoma. Int J Cancer. 2006;118:916-23 pubmed
    ..038, relative risk 10.5). These results indicate that the promoter methylation of the 4.1B is one of the most frequent epigenetic alterations in RCCC and could predict the metastatic recurrence of the surgically resected RCCC. ..
  7. Kikuchi S, Yamada D, Fukami T, Masuda M, Sakurai Yageta M, Williams Y, et al. Promoter methylation of DAL-1/4.1B predicts poor prognosis in non-small cell lung cancer. Clin Cancer Res. 2005;11:2954-61 pubmed
    ..0011 and P = 0.045, respectively). DAL-1 methylation is involved in the development and progression of NSCLC and provides an indicator for poor prognosis. ..
  8. Cifuentes Diaz C, Chareyre F, Garcia M, Devaux J, Carnaud M, Levasseur G, et al. Protein 4.1B contributes to the organization of peripheral myelinated axons. PLoS ONE. 2011;6:e25043 pubmed publisher
    ..Thus, our results show that in myelinated axons 4.1B contributes to the stabilization of membrane proteins at paranodes, to the clustering of juxtaparanodal proteins, and to the regulation of the internodal axon caliber. ..
  9. Yu T, Robb V, Singh V, Gutmann D, Newsham I. The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins. Biochem J. 2002;365:783-9 pubmed
    ..1/ezrin/radixin/moesin domain. The identification of this novel DAL-1/Protein 4.1B-interacting protein represents the first step towards elucidating its potentially unique mechanism of action. ..

More Information

Publications70

  1. Tran Y, Bogler O, Gorse K, Wieland I, Green M, Newsham I. A novel member of the NF2/ERM/4.1 superfamily with growth suppressing properties in lung cancer. Cancer Res. 1999;59:35-43 pubmed
    ..1 superfamily including ezrin and NF2. The data suggest DAL-1 is a novel membrane-associated protein with potential to play an important role in the origin and progression of lung cancer. ..
  2. Kittiniyom K, Mastronardi M, Roemer M, Wells W, Greenberg E, Titus Ernstoff L, et al. Allele-specific loss of heterozygosity at the DAL-1/4.1B (EPB41L3) tumor-suppressor gene locus in the absence of mutation. Genes Chromosomes Cancer. 2004;40:190-203 pubmed
    ..These studies indicate that mechanisms such as imprinting or monoallelic expression in combination with loss of heterozygosity may be responsible for loss of the DAL-1/4.1B protein in early breast disease. ..
  3. Denisenko Nehrbass N, Oguievetskaia K, Goutebroze L, Galvez T, Yamakawa H, Ohara O, et al. Protein 4.1B associates with both Caspr/paranodin and Caspr2 at paranodes and juxtaparanodes of myelinated fibres. Eur J Neurosci. 2003;17:411-6 pubmed
    ..1B with Caspr/paranodin at paranodes and with Caspr2 at juxtaparanodes. We propose that 4.1B anchors these axonal proteins to the actin-based cytoskeleton in these two regions. ..
  4. Ohno N, Terada N, Murata S, Yamakawa H, Newsham I, Katoh R, et al. Immunolocalization of protein 4.1B/DAL-1 during neoplastic transformation of mouse and human intestinal epithelium. Histochem Cell Biol. 2004;122:579-86 pubmed
    ..We propose that loss of protein 4.1B/DAL-1 expression might be a marker of intestinal tumors, indicative of a tumor suppressor function in the intestinal mucosa. ..
  5. Takahashi Y, Iwai M, Kawai T, Arakawa A, Ito T, Sakurai Yageta M, et al. Aberrant expression of tumor suppressors CADM1 and 4.1B in invasive lesions of primary breast cancer. Breast Cancer. 2012;19:242-52 pubmed publisher
    ..Our findings suggest that aberrant CADM1 and 4.1B expression is involved in progression of breast cancer, especially in invasion into the stroma and metastasis. ..
  6. Busam R, Thorsell A, Flores A, Hammarström M, Persson C, Obrink B, et al. Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B). J Biol Chem. 2011;286:4511-6 pubmed publisher
    ..Our results refute earlier exon deletion experiments that indicated that glycophorin C interacts with the ?-lobe of 4.1 FERM domains. ..
  7. Gutmann D, Donahoe J, Perry A, Lemke N, Gorse K, Kittiniyom K, et al. Loss of DAL-1, a protein 4.1-related tumor suppressor, is an important early event in the pathogenesis of meningiomas. Hum Mol Genet. 2000;9:1495-500 pubmed
  8. Wong S, Haack H, Kissil J, Barry M, Bronson R, Shen S, et al. Protein 4.1B suppresses prostate cancer progression and metastasis. Proc Natl Acad Sci U S A. 2007;104:12784-9 pubmed
    ..1B as a negative regulator of cancer progression to metastatic disease. ..
  9. Lorincz A, Brentnall A, Scibior Bentkowska D, Reuter C, Banwait R, Cadman L, et al. Validation of a DNA methylation HPV triage classifier in a screening sample. Int J Cancer. 2016;138:2745-51 pubmed publisher
    ..0001). Thus, a DNA methylation test for the triage of hrHPV-positive women on original screening specimens might be a valid approach with better performance than genotyping. ..
  10. Brentnall A, Vasiljevic N, Scibior Bentkowska D, Cadman L, Austin J, Cuzick J, et al. HPV33 DNA methylation measurement improves cervical pre-cancer risk estimation of an HPV16, HPV18, HPV31 and \textit{EPB41L3} methylation classifier. Cancer Biomark. 2015;15:669-75 pubmed publisher
    ..Other HPV and human methylation target regions might be useful to further improve S5. ..
  11. Pereira G, Malheiros J, Ospina A, Chardulo L, Curi R. Exome sequencing in genomic regions related to racing performance of Quarter Horses. J Appl Genet. 2019;60:79-86 pubmed publisher
  12. Simonetti V, Comparcini D, Buccolini M, Cicolini G. [Index of Caring Complexity as a management tool in a surgical setting: an observational study]. Prof Inferm. 2014;67:235-42 pubmed publisher
    ..Sono stati raccolti i dati di tutti i pazienti ricoverati in regime ordinario, dal 1 gennaio al 30 aprile 2010, al fine di determinare cinque classi di gravità media modale per ciascun paziente e ..
  13. Iwasaki T, Matsushita M, Nonaka D, Nagata K, Kato M, Kuwamoto S, et al. Lower expression of CADM1 and higher expression of MAL in Merkel cell carcinomas are associated with Merkel cell polyomavirus infection and better prognosis. Hum Pathol. 2016;48:1-8 pubmed publisher
    ..of prognosis or MCPyV infection status in MCCs with cell adhesion molecule 1 (CADM1)/differentially expressed in adenocarcinoma of the lung protein 1 (DAL-1)/membrane protein, palmitoylated 3 (MPP3) tripartite complex and mal T-cell ..
  14. Blanco Luquin I, Guarch R, Ojer A, Pérez Janices N, Martín Sánchez E, Maria Ruiz S, et al. Differential role of gene hypermethylation in adenocarcinomas, squamous cell carcinomas and cervical intraepithelial lesions of the uterine cervix. Pathol Int. 2015;65:476-85 pubmed publisher
    ..These results suggest that the involvement of DNA hypermethylation in cervical cancer varies depending on the histological type, which might contribute to explaining the different prognosis of patients with these types of tumors. ..
  15. Lee C, Chung C, Kim C. Genetic differences on intracranial versus spinal cord ependymal tumors: a meta-analysis of genetic researches. Eur Spine J. 2016;25:3942-3951 pubmed
    ..The difference in prognosis of ependymoma by location may be associated with genetic difference. A more detailed understanding of them may enable the development of targeted therapy and the estimation of prognosis. ..
  16. Lipus D, Vikram A, Ross D, Bibby K. Draft Genome Sequence of Methanohalophilus mahii Strain DAL1 Reconstructed from a Hydraulic Fracturing-Produced Water Metagenome. Genome Announc. 2016;4: pubmed publisher
    We report here the 1,882,100-bp draft genome sequence of Methanohalophilus mahii strain DAL1, recovered from Marcellus Shale hydraulic fracturing-produced water using metagenomic contig binning...
  17. Aziz F. The emerging role of miR-223 as novel potential diagnostic and therapeutic target for inflammatory disorders. Cell Immunol. 2016;303:1-6 pubmed publisher
    ..In this review, we summarized the recent studies of miR-223, their mechanisms to develop inflammation diseases and its importance role to use as biomarkers for early diagnosis and therapeutic target against inflammation diseases. ..
  18. Di Cosmo S, Lusignani M, Manini M, Accardi R. [Prevalence and risk factors of overweight and obesity after liver transplantation: retrospective study at three years after transplantation]. Prof Inferm. 2018;71:3-10 pubmed publisher
    ..a Trapianto di Fegato, presso la Fondazione IRCCS “ Cà Granda – Ospedale Maggiore Policlinico” di Milano dal 1° Gennaio 2005 al 30 Giugno 2014...
  19. Basnayake B, Li D, Zhang H, Li G, Virk N, Song F. Arabidopsis DAL1 and DAL2, two RING finger proteins homologous to Drosophila DIAP1, are involved in regulation of programmed cell death. Plant Cell Rep. 2011;30:37-48 pubmed publisher
    ..However, the genetic mechanisms that control PCD in plants are unclear. Two Arabidopsis genes, DAL1 and DAL2 (for Drosophila DIAP1 like 1 and 2), encoding RING finger proteins with homology to DIAP1 were identified, ..
  20. Ibstedt S, Stenberg S, Bagés S, Gjuvsland A, Salinas F, Kourtchenko O, et al. Concerted evolution of life stage performances signals recent selection on yeast nitrogen use. Mol Biol Evol. 2015;32:153-61 pubmed publisher
    ..further traced QTLs down to single-nucleotide resolution and uncovered loss-of-function mutations in RIM15, PUT4, DAL1, and DAL4 as the genetic basis for nitrogen source use variations...
  21. Vasiljević N, Ahmad A, Carter P, Fisher G, Berney D, Foster C, et al. DNA methylation of PITX2 predicts poor survival in men with prostate cancer. Biomark Med. 2014;8:1143-50 pubmed publisher
    ..17-2.08; p = 0.005). Our study strengthens prior findings that PITX2 methylation is useful as a biomarker of poor outcome of PCa and in addition we also suggest that it may be particularly useful in men with low Gleason score. ..
  22. Men Y, Kang Q, Ding C, Liu S, Jiang H, Wang X, et al. [Expression of protein 4.1 family in melanoma cell lines and its effect on cell proliferation]. Nan Fang Yi Ke Da Xue Xue Bao. 2016;36:649-54 pubmed
    ..The eukaryotic expression vector carrying EPB41L3 sequence is capable of inhibiting the proliferation of mouse melanoma B16 and B16-F10 cells. ..
  23. Boers A, Wang R, van Leeuwen R, Klip H, de Bock G, Hollema H, et al. Discovery of new methylation markers to improve screening for cervical intraepithelial neoplasia grade 2/3. Clin Epigenetics. 2016;8:29 pubmed publisher
    ..The next step before implementation in primary screening programs will be validation in population-based cohorts. ..
  24. Zeng R, Liu Y, Jiang Z, Huang J, Wang Y, Li X, et al. EPB41L3 is a potential tumor suppressor gene and prognostic indicator in esophageal squamous cell carcinoma. Int J Oncol. 2018;: pubmed publisher
    ..In summary, the present results suggest that EPB41L3 may be a tumor suppressor gene in ESCC development, representing a potential therapeutic target and a prognostic indicator for ESCC. ..
  25. Martin Sanchez E, Pernaut Leza E, Mendaza S, Cordoba A, Vicente García F, Monreal Santesteban I, et al. Gene promoter hypermethylation is found in sentinel lymph nodes of breast cancer patients, in samples identified as positive by one-step nucleic acid amplification of cytokeratin 19 mRNA. Virchows Arch. 2016;469:51-9 pubmed publisher
    ..002). We show that samples used for OSNA are suitable for molecular studies, including gene promoter methylation. These samples provide a new source of material for the identification of additional biomarkers. ..
  26. Rogeri C, Silveira H, Causin R, Villa L, Stein M, de Carvalho A, et al. Methylation of the hsa-miR-124, SOX1, TERT, and LMX1A genes as biomarkers for precursor lesions in cervical cancer. Gynecol Oncol. 2018;150:545-551 pubmed publisher
    ..5). Hypermethylation of the hsa-miR-124-2, SOX1, TERT, and LMX1A genes may be a promising biomarker for precursor lesions in cervical cancer regardless of the hr-HPV status. ..
  27. D Antonio S, Bagnasco A, Bonetti L, Sasso L. [Observational study on interruptions during nurses work in two surgical wards of a hospital in Liguria]. Prof Inferm. 2014;67:211-8 pubmed publisher
    ..L’osservazione è durata 1 mese, dal 1 luglio 2012 al 1 agosto 2012...
  28. Eijsink J, Lendvai A, Deregowski V, Klip H, Verpooten G, Dehaspe L, et al. A four-gene methylation marker panel as triage test in high-risk human papillomavirus positive patients. Int J Cancer. 2012;130:1861-9 pubmed publisher
    ..In conclusion, our four-gene methylation panel might provide an alternative triage test after primary hr-HPV testing...
  29. Yu F, Yang H, Zhang Z, Wang Z, Xiong J. DAL-1/4.1B contributes to epithelial-mesenchymal transition via regulation of transforming growth factor-β in lung cancer cell lines. Mol Med Rep. 2015;12:6072-8 pubmed publisher
    ..The results of the present study provided evidence for the feasibility of utilizing DAL‑1/4.1B as a target for lung cancer gene therapy. ..
  30. Chen X, Guan X, Zhang H, Xie X, Wang H, Long J, et al. DAL-1 attenuates epithelial-to mesenchymal transition in lung cancer. J Exp Clin Cancer Res. 2015;34:3 pubmed publisher
    ..Strikingly, HSPA5 was found as DAL-1 direct binding protein. These results suggest that tumor suppressor DAL-1 could also attenuate EMT and be important for tumor metastasis in the early transformation process in lung cancer. ..
  31. Rangel L, Lospitao E, Ruiz Sáenz A, Alonso M, Correas I. Alternative polyadenylation in a family of paralogous EPB41 genes generates protein 4.1 diversity. RNA Biol. 2017;14:236-244 pubmed publisher
    ..1 protein diversity in the already complex EPB41-related genes. Understanding the diversity of EPB41 RNA processing is essential for a full appreciation of the many 4.1 proteins expressed in normal and pathological tissues. ..
  32. Wang Z, Yang K, Wang X, Zhang J, Hao D, Chen Z. [Expressions and clinical significances of TSLC1 and 4.1B in non-small cell lung cancer]. Zhongguo Fei Ai Za Zhi. 2010;13:1041-5 pubmed publisher
    ..1B in non-small cell lung cancer, both may participate in a cascade of non-small cell lung cancer occurrence and development. TSLC1 and 4.1B are promising targets for non-small cell lung cancer diagnosis and treatment. ..
  33. Wang Z, Zhang J, Zeng Y, Sun S, Zhang J, Zhang B, et al. Knockout of 4.1B triggers malignant transformation in SV40T-immortalized mouse embryo fibroblast cells. Mol Carcinog. 2017;56:538-549 pubmed publisher
    ..1B-/- iMEFs. Moreover, we showed that 4.1B interacted with E-cadherin in MEF cells. Thus, our study provides previously unidentified roles and mechanisms of 4.1B in cellular transformation. © 2016 Wiley Periodicals, Inc. ..
  34. Nunes F, Shen Y, Niida Y, Beauchamp R, Stemmer Rachamimov A, Ramesh V, et al. Inactivation patterns of NF2 and DAL-1/4.1B (EPB41L3) in sporadic meningioma. Cancer Genet Cytogenet. 2005;162:135-9 pubmed
    ..Furthermore, we found the majority of meningiomas developed monosomy rather than isodisomy at the NF2 and DAL-1/4.1B loci as the mechanism for LOH. ..
  35. Wang H, Xu M, Cui X, Liu Y, Zhang Y, Sui Y, et al. Aberrant expression of the candidate tumor suppressor gene DAL-1 due to hypermethylation in gastric cancer. Sci Rep. 2016;6:21755 pubmed publisher
    ..Understanding the role of it played in the molecular pathogenesis of GC, DAL-1 might be a potential biomarker for molecular diagnosis and evaluation of the GC. ..
  36. Zeng R, Huang J, Li X, Xiong W, Wu G, Jiang Z, et al. Epb41l3 suppresses esophageal squamous cell carcinoma invasion and inhibits MMP2 and MMP9 expression. Cell Biochem Funct. 2016;34:133-41 pubmed publisher
    ..Furthermore, overexpressing epb41l3 led to downregulation of MMP2 and MMP9 in Kyse150 and Kyse510 cells. Our findings reveal that EPB41L3 suppresses tumour cell invasion and inhibits MMP2 and MMP9 expression in ESCC cells. ..
  37. Perez Janices N, Blanco Luquin I, Tuñón M, Barba Ramos E, Ibáñez B, Zazpe Cenoz I, et al. EPB41L3, TSP-1 and RASSF2 as new clinically relevant prognostic biomarkers in diffuse gliomas. Oncotarget. 2015;6:368-80 pubmed
    ..001). We conclude that EPB41L3, RASSF2 and TSP-1 genes are involved in the pathogenesis of diffuse gliomas, and that EPB41L3 and TSP-1 hypermethylation are of prognostic significance. ..
  38. Barzilay E, Yung Y, Shapira L, Haas J, Ophir L, Yerushalmi G, et al. Differential expression of poliovirus receptor, regulator of G-protein signaling 11 and erythrocyte protein band 4.1-like 3 in human granulosa cells during follicular growth and maturation. Gynecol Endocrinol. 2014;30:660-3 pubmed publisher
    ..In conclusion, during human follicular maturation there are significant changes in expression of PVR, RGS11 and EPB41L3, possibly regulated by progesterone. ..
  39. Tan J, Mohandas N, Conboy J. Evolutionarily conserved coupling of transcription and alternative splicing in the EPB41 (protein 4.1R) and EPB41L3 (protein 4.1B) genes. Genomics. 2005;86:701-7 pubmed
    ..We propose that these genes represent a physiologically relevant model system for mechanistic analysis of transcription-coupled alternative splicing. ..
  40. Martinez Glez V, Bello M, Franco Hernandez C, de Campos J, Isla A, Vaquero J, et al. Mutational analysis of the DAL-1/4.1B tumour-suppressor gene locus in meningiomas. Int J Mol Med. 2005;16:771-4 pubmed
    ..1B as the main mechanism underlying participation of this gene in the neoplastic transformation of meningiomas, and suggests that other inactivating mechanisms, such as epigenetic changes, may participate in DAL1/4.1B silencing.
  41. Robb V, Li W, Gutmann D. Disruption of 14-3-3 binding does not impair Protein 4.1B growth suppression. Oncogene. 2004;23:3589-96 pubmed
    ..Collectively, these results suggest that binding to 14-3-3 is not essential for the growth suppressor function of Protein 4.1B in meningiomas. ..
  42. Zhang Y, Xu R, Li G, Xie X, Long J, Wang H. Loss of expression of the differentially expressed in adenocarcinoma of the lung (DAL-1) protein is associated with metastasis of non-small cell lung carcinoma cells. Tumour Biol. 2012;33:1915-25 pubmed publisher
    ..These results indicated that DAL-1 was pivotal in triggering NSCLC migration and invasion and that loss of DAL-1 expression was due to the epigenetic methylation. ..
  43. Heinrich B, Hartmann C, Stemmer Rachamimov A, Louis D, MacCollin M. Multiple meningiomas: Investigating the molecular basis of sporadic and familial forms. Int J Cancer. 2003;103:483-8 pubmed
    ..DAL-1 does not function as a true tumor suppressor in these patients. ..
  44. St Pourcain B, Skuse D, Mandy W, Wang K, Hakonarson H, Timpson N, et al. Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence. Mol Autism. 2014;5:18 pubmed publisher
    ..007). Our findings suggest that measurable common genetic effects for social-communication difficulties vary developmentally and that these changes may affect detectable overlaps with the autism spectrum. ..
  45. Jiang W, Newsham I. The tumor suppressor DAL-1/4.1B and protein methylation cooperate in inducing apoptosis in MCF-7 breast cancer cells. Mol Cancer. 2006;5:4 pubmed
    ..1B to induce cell death. These results suggest that protein methylation cooperates with DAL-1/4.1B-associated caspase 8-specific activation to induce apoptosis in breast cancer cells. ..
  46. Li X, Zhang Y, Zhang H, Liu X, Gong T, Li M, et al. miRNA-223 promotes gastric cancer invasion and metastasis by targeting tumor suppressor EPB41L3. Mol Cancer Res. 2011;9:824-33 pubmed publisher
    ..These findings indicate a new regulatory mode, namely, specific miRNA, which is activated by its upstream transcription factor, could suppress its direct targets and lead to tumor invasion and metastasis. ..
  47. Robb V, Gerber M, Hart Mahon E, Gutmann D. Membrane localization of the U2 domain of Protein 4.1B is necessary and sufficient for meningioma growth suppression. Oncogene. 2005;24:1946-57 pubmed
    ..Collectively, the data suggest that the U2 domain, when properly targeted to the plasma membrane, contains all the residues necessary for mediating Protein 4.1B growth suppression. ..
  48. Abu Farha M, Lambert J, Al Madhoun A, Elisma F, Skerjanc I, Figeys D. The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase. Mol Cell Proteomics. 2008;7:560-72 pubmed
    ..Furthermore the combination of the SMYD2 interactome with the gene expression data suggests that some of the genes regulated by SMYD2 are closely associated with SMYD2-interacting proteins. ..
  49. Zhu L, Yang N, Chen J, Zeng T, Yan S, Liu Y, et al. LINC00052 upregulates EPB41L3 to inhibit migration and invasion of hepatocellular carcinoma by binding miR-452-5p. Oncotarget. 2017;8:63724-63737 pubmed publisher
    ..In conclusion, these results demonstrated that a novel pathway was mediated by LINC00052 in HCC...
  50. Calinisan V, Gravem D, Chen R, Brittin S, Mohandas N, Lecomte M, et al. New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium. Front Biosci. 2006;11:1646-66 pubmed
    ..We also discuss the functional relevance of another member of the protein 4.1 superfamily, ezrin, in kidney physio-pathology. ..
  51. Liang H, Yan X, Pan Y, Wang Y, Wang N, Li L, et al. MicroRNA-223 delivered by platelet-derived microvesicles promotes lung cancer cell invasion via targeting tumor suppressor EPB41L3. Mol Cancer. 2015;14:58 pubmed publisher
    ..Our study demonstrates for the first time that platelet-secreted miR-223 via P-MVs can promote lung cancer cell invasion via targeting tumor suppressor EPB41L3. ..
  52. Hoy J, Constable J, Vicini S, Fu Z, Washbourne P. SynCAM1 recruits NMDA receptors via protein 4.1B. Mol Cell Neurosci. 2009;42:466-83 pubmed publisher
    ..1N to specifically effect AMPA type receptor (AMPAR) recruitment. Thus, SynCAM1 may recruit both AMPARs and NMDARs by independent mechanisms during synapse formation. ..
  53. Qiu X, Guan X, Liu W, Zhang Y. DAL-1 attenuates epithelial to mesenchymal transition and metastasis by suppressing HSPA5 expression in non-small cell lung cancer. Oncol Rep. 2017;38:3103-3113 pubmed publisher
    ..Furthermore, we discovered that DAL-1 plays a role in inhibiting PI3K/Akt/Mdm2 signaling pathway by suppressing HSPA5...
  54. Adams M, Soares M, Kerlavage A, Fields C, Venter J. Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library. Nat Genet. 1993;4:373-80 pubmed
    ..37% of the clones were identified, based on matches to over 320 different genes in the public databases. Of these, two proteins similar to the Alzheimer's disease amyloid precursor protein were identified. ..
  55. Sakurai Yageta M, Maruyama T, Suzuki T, Ichikawa K, Murakami Y. Dynamic regulation of a cell adhesion protein complex including CADM1 by combinatorial analysis of FRAP with exponential curve-fitting. PLoS ONE. 2015;10:e0116637 pubmed publisher
    ..Our analyses reveal a central role of CADM1 in stabilizing the complex with 4.1B and MPP3 and provide insight in the dynamics of adhesion complex formation. ..
  56. Rajaram V, Gutmann D, Prasad S, Mansur D, Perry A. Alterations of protein 4.1 family members in ependymomas: a study of 84 cases. Mod Pathol. 2005;18:991-7 pubmed
    ..009). We conclude that alterations of Protein 4.1 family members are common in ependymal tumors and that specific alterations are associated with distinct clinicopathologic subsets. ..
  57. Dafou D, Grun B, Sinclair J, Lawrenson K, Benjamin E, Hogdall E, et al. Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers. Neoplasia. 2010;12:579-89 pubmed
    ..Finally, an inducible model of EPB41L3 expression in three-dimensional spheroids confirmed that reexpression of EPB41L3 induces extensive apoptotic cell death in ovarian cancers...
  58. Heller G, Fong K, Girard L, Seidl S, End Pfützenreuter A, Lang G, et al. Expression and methylation pattern of TSLC1 cascade genes in lung carcinomas. Oncogene. 2006;25:959-68 pubmed
    ..Our results suggest that methylation of TSLC1 and/or DAL-1, leading to loss of their expression, is an important event in the pathogenesis of NSCLC. ..
  59. Wang Z, Zhang J, Ye M, Zhu M, Zhang B, Roy M, et al. Tumor suppressor role of protein 4.1B/DAL-1. Cell Mol Life Sci. 2014;71:4815-30 pubmed publisher
    ..This review will focus on the structure of protein 4.1B/DAL-1, 4.1B/DAL-1-interacting molecules, 4.1B/DAL-1 inactivation and tumor progression, and anti-tumor activity of the 4.1B/DAL-1. ..
  60. Fu L, Gao Z, Zhang X, Tsang Y, Goh H, Geng H, et al. Frequent concomitant epigenetic silencing of the stress-responsive tumor suppressor gene CADM1, and its interacting partner DAL-1 in nasal NK/T-cell lymphoma. Int J Cancer. 2009;124:1572-8 pubmed publisher
    ..The stress-response of CADM1 was abolished when its promoter becomes methylated. Our results demonstrate a frequent, predominant epigenetic silencing of CADM1 and DAL-1 in NL, which likely play a synergic role in NL pathogenesis. ..
  61. Bernkopf D, Williams E. Potential role of EPB41L3 (protein 4.1B/Dal-1) as a target for treatment of advanced prostate cancer. Expert Opin Ther Targets. 2008;12:845-53 pubmed
    ..Therapeutic strategies that could be harnessed to upregulate EPB41L3 gene expression in prostate cancer cells are currently being developed. ..