DAGLB

Summary

Gene Symbol: DAGLB
Description: diacylglycerol lipase beta
Alias: DAGLBETA, KCCR13L, sn1-specific diacylglycerol lipase beta, DGL-beta
Species: human
Products:     DAGLB

Top Publications

  1. Márquez L, Suarez J, Iglesias M, Bermudez Silva F, Rodriguez de Fonseca F, Andreu M. Ulcerative colitis induces changes on the expression of the endocannabinoid system in the human colonic tissue. PLoS ONE. 2009;4:e6893 pubmed publisher
    ..Cannabinoid CB(1) and CB(2) receptors, the enzymes for endocannabinoid biosynthesis DAGLalpha, DAGLbeta and NAPE-PLD, and the endocannabinoid-degradating enzymes FAAH and MAGL were analysed in both acute untreated ..
  2. Powell D, Gay J, Wilganowski N, Doree D, Savelieva K, Lanthorn T, et al. Diacylglycerol Lipase α Knockout Mice Demonstrate Metabolic and Behavioral Phenotypes Similar to Those of Cannabinoid Receptor 1 Knockout Mice. Front Endocrinol (Lausanne). 2015;6:86 pubmed publisher
    ..We asked if our KOs of DAG lipase α or β (Dagla or Daglb), which catalyze biosynthesis of the endocannabinoid (EC) 2-arachidonoylglycerol (2-AG), or Napepld, which ..
  3. Carey C, Agrawal A, Zhang B, Conley E, Degenhardt L, Heath A, et al. Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis. J Abnorm Psychol. 2015;124:860-77 pubmed publisher
    ..Comorbidity and Trauma Study (N = 1,558) to examine whether genetic variation in six eCB genes (anabolism: DAGLA, DAGLB, NAPEPLD; catabolism: MGLL, FAAH; binding: CNR1; SNPs N = 65) and childhood sexual abuse (CSA) predict cannabis ..
  4. Melroy Greif W, Wilhelmsen K, Ehlers C. Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans. Drug Alcohol Depend. 2016;166:249-53 pubmed publisher
    ..and CUDs were examined in a community sample of young adult Mexican Americans (MAs): CNR1, MGLL, FAAH, DAGLA, and DAGLB. Gene-based tests were run to test for association between each gene and two DSM-5 cannabis phenotypes...
  5. Zhou D, Zhang D, Sun X, Li Z, Ni Y, Shan Z, et al. A novel variant associated with HDL-C levels by modifying DAGLB expression levels: An annotation-based genome-wide association study. Eur J Hum Genet. 2018;26:838-847 pubmed publisher
    ..6435220G>C) was replicated (Pcombined = 1.4E-10). rs1880118 was associated with DAGLB (diacylglycerol lipase, beta) expression levels in subcutaneous adipose tissue (P = 5.9E-42) and explained 47...
  6. Bisogno T, Howell F, Williams G, Minassi A, Cascio M, Ligresti A, et al. Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J Cell Biol. 2003;163:463-8 pubmed
    ..This switch provides a possible explanation for a fundamental change in endocannabinoid function during brain development. Identification of these enzymes may offer new therapeutic opportunities for a wide range of disorders. ..
  7. Singh P, Markwick R, Lu L, Howell F, Williams G, Doherty P. Assay and Inhibition of the Purified Catalytic Domain of Diacylglycerol Lipase Beta. Biochemistry. 2016;55:2713-21 pubmed publisher
    ..The purified DAGL? catalytic domain assay described here provides the basis for a relatively clean and convenient assay with the potential to be adapted for high-throughput drug discovery efforts. ..