Gene Symbol: DAGLA
Description: diacylglycerol lipase alpha
Alias: C11orf11, DAGL(ALPHA), DAGLALPHA, NSDDR, sn1-specific diacylglycerol lipase alpha, DGL-alpha, neural stem cell-derived dendrite regulator
Species: human
Products:     DAGLA

Top Publications

  1. Bisogno T, Howell F, Williams G, Minassi A, Cascio M, Ligresti A, et al. Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J Cell Biol. 2003;163:463-8 pubmed
    ..This switch provides a possible explanation for a fundamental change in endocannabinoid function during brain development. Identification of these enzymes may offer new therapeutic opportunities for a wide range of disorders. ..
  2. Márquez L, Suarez J, Iglesias M, Bermudez Silva F, Rodriguez de Fonseca F, Andreu M. Ulcerative colitis induces changes on the expression of the endocannabinoid system in the human colonic tissue. PLoS ONE. 2009;4:e6893 pubmed publisher
    ..Cannabinoid CB(1) and CB(2) receptors, the enzymes for endocannabinoid biosynthesis DAGLalpha, DAGLbeta and NAPE-PLD, and the endocannabinoid-degradating enzymes FAAH and MAGL were analysed in both acute ..
  3. Agbenyegah S, Abend M, Atkinson M, Combs S, Trott K, Port M, et al. Impact of Inter-Individual Variance in the Expression of a Radiation-Responsive Gene Panel Used for Triage. Radiat Res. 2018;190:226-235 pubmed publisher
    ..In addition to the eight candidate genes ( DAGLA, WNT3, CD177, PLA2G16, WLS, POU2AF1, STAT4 and PRF1), we examined two more genes ( FDXR and DDB2) widely used in ..
  4. Okubo Y, Kasamatsu A, Yamatoji M, Fushimi K, Ishigami T, Shimizu T, et al. Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression. Exp Cell Res. 2018;367:112-118 pubmed publisher
    Diacylglycerol lipase alpha (DAGLA), which catalyzes the hydrolysis of diacylglycerol to 2-arachidonoylglycerol and free fatty acid, is required for axonal growth during the brain development and for retrograde synaptic signaling at ..
  5. Baggelaar M, Van Der Stelt M. Competitive ABPP of Serine Hydrolases: A Case Study on DAGL-Alpha. Methods Mol Biol. 2017;1491:161-169 pubmed
  6. Carey C, Agrawal A, Zhang B, Conley E, Degenhardt L, Heath A, et al. Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis. J Abnorm Psychol. 2015;124:860-77 pubmed publisher
    ..the Comorbidity and Trauma Study (N = 1,558) to examine whether genetic variation in six eCB genes (anabolism: DAGLA, DAGLB, NAPEPLD; catabolism: MGLL, FAAH; binding: CNR1; SNPs N = 65) and childhood sexual abuse (CSA) predict ..
  7. Ishiguro H, Higuchi S, Arinami T, Onaivi E. Association between alcoholism and the gene encoding the endocannabinoid synthesizing enzyme diacylglycerol lipase alpha in the Japanese population. Alcohol. 2018;68:59-62 pubmed publisher
    ..This study investigated the involvement of the 2-AG biosynthesizing enzyme diacylglycerol lipase alpha (DAGLA) in the pathogenesis of alcoholism...
  8. Melroy Greif W, Wilhelmsen K, Ehlers C. Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans. Drug Alcohol Depend. 2016;166:249-53 pubmed publisher
    ..system and CUDs were examined in a community sample of young adult Mexican Americans (MAs): CNR1, MGLL, FAAH, DAGLA, and DAGLB. Gene-based tests were run to test for association between each gene and two DSM-5 cannabis phenotypes...
  9. Jenniches I, Ternes S, Albayram O, Otte D, Bach K, Bindila L, et al. Anxiety, Stress, and Fear Response in Mice With Reduced Endocannabinoid Levels. Biol Psychiatry. 2016;79:858-868 pubmed publisher
    ..We generated and used knockout mice lacking DAGL-α (Dagla(-/-)) to assess the behavioral consequences of reduced endocannabinoid levels in the brain...

More Information


  1. Powell D, Gay J, Wilganowski N, Doree D, Savelieva K, Lanthorn T, et al. Diacylglycerol Lipase α Knockout Mice Demonstrate Metabolic and Behavioral Phenotypes Similar to Those of Cannabinoid Receptor 1 Knockout Mice. Front Endocrinol (Lausanne). 2015;6:86 pubmed publisher
    ..We asked if our KOs of DAG lipase α or β (Dagla or Daglb), which catalyze biosynthesis of the endocannabinoid (EC) 2-arachidonoylglycerol (2-AG), or Napepld, ..
  2. Kita Y, Yoshida K, Tokuoka S, Hamano F, Yamazaki M, Sakimura K, et al. Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2. PLoS ONE. 2015;10:e0133663 pubmed publisher
    ..phospholipase A2α (cPLA2α)-deficient (Pla2g4a-/-) mice, and diacylglycerol lipase α (DGLα)-deficient (Dagla-/-) mice...
  3. Port M, Herodin F, Valente M, Drouet M, Lamkowski A, Majewski M, et al. First Generation Gene Expression Signature for Early Prediction of Late Occurring Hematological Acute Radiation Syndrome in Baboons. Radiat Res. 2016;186:39-54 pubmed publisher
    ..For H2-3, some genes appeared four to sevenfold up-regulated relative to H0 (RNASE3, DAGLA, ARG2), but other genes showed a strong 14- to 33-fold down-regulation relative to H0 (WNT3, POU2AF1, CCR7)...
  4. Hassanlou M, Soltani B, Mowla S. Expression and Function of hsa-miR-6165 in Human Cell Lines and During the NT2 Cell Neural Differentiation Process. J Mol Neurosci. 2017;63:254-266 pubmed publisher
    ..Hsa-miR-6165 overexpression in SW480 cells also resulted in significant downregulation of PKD1, DAGLA, and PLXNA2 putative target genes, while it increases the sub-G1 cell population of SW480 and HEK293T cells as ..
  5. Smith D, Stanley C, Foss T, Boles R, McKernan K. Rare genetic variants in the endocannabinoid system genes CNR1 and DAGLA are associated with neurological phenotypes in humans. PLoS ONE. 2017;12:e0187926 pubmed publisher
    Rare genetic variants in the core endocannabinoid system genes CNR1, CNR2, DAGLA, MGLL and FAAH were identified in molecular testing data from 6,032 patients with a broad spectrum of neurological disorders...
  6. Engeli S, Lehmann A, Kaminski J, Haas V, Janke J, Zoerner A, et al. Influence of dietary fat intake on the endocannabinoid system in lean and obese subjects. Obesity (Silver Spring). 2014;22:E70-6 pubmed publisher
    ..Weight-neutral changes in dietary fat intake cannot explain excessive endocannabinoid availability in human obesity. Obesity and dietary fat intake affect ECS gene expression in a tissue-specific manner. ..
  7. Martella A, Sepe R, Silvestri C, Zang J, Fasano G, Carnevali O, et al. Important role of endocannabinoid signaling in the development of functional vision and locomotion in zebrafish. FASEB J. 2016;30:4275-4288 pubmed
    ..development and show that the genes that code for enzymes that catalyze the anabolism and catabolism (mgll and dagla) of the endocannabinoid, 2-AG (2-arachidonoylglycerol), as well as 2-AG main receptor in the brain, cannabinoid ..
  8. Garcia del Caño G, Montaña M, Aretxabala X, González Burguera I, López de Jesús M, Barrondo S, et al. Nuclear phospholipase C-?1 and diacylglycerol LIPASE-? in brain cortical neurons. Adv Biol Regul. 2014;54:12-23 pubmed publisher
  9. Long L, Lind J, Webster M, Weickert C. Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex. BMC Neurosci. 2012;13:87 pubmed publisher
    ..Thus, expression of key genes in the endocannabinoid system changes with maturation of cortical function. ..
  10. Knight M, Hernandez D, Diede S, Dauwerse H, Rafferty I, van de Leemput J, et al. A duplication at chromosome 11q12.2-11q12.3 is associated with spinocerebellar ataxia type 20. Hum Mol Genet. 2008;17:3847-53 pubmed publisher
    ..be pathogenic remains to be established, we speculate that the critical gene within the duplicated segment may be DAGLA, the product of which is normally present at the base of Purkinje cell dendritic spines and contributes to the ..
  11. Jung K, Mangieri R, Stapleton C, Kim J, Fegley D, Wallace M, et al. Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors. Mol Pharmacol. 2005;68:1196-202 pubmed
    ..The results suggest that 2-AG is a primary endocannabinoid mediator of mGlu receptor-dependent neuronal plasticity. ..