DAG1

Summary

Gene Symbol: DAG1
Description: dystroglycan 1
Alias: 156DAG, A3a, AGRNR, DAG, MDDGA9, MDDGC7, MDDGC9, dystroglycan, dystroglycan 1 (dystrophin-associated glycoprotein 1)
Species: human
Products:     DAG1

Top Publications

  1. Sotgia F, Lee J, Das K, Bedford M, Petrucci T, Macioce P, et al. Caveolin-3 directly interacts with the C-terminal tail of beta -dystroglycan. Identification of a central WW-like domain within caveolin family members. J Biol Chem. 2000;275:38048-58 pubmed
    ..Here, we demonstrate that caveolin-3 directly interacts with beta-dystroglycan, an integral membrane component of the dystrophin complex...
  2. Sgambato A, de Paola B, Migaldi M, Di Salvatore M, Rettino A, Rossi G, et al. Dystroglycan expression is reduced during prostate tumorigenesis and is regulated by androgens in prostate cancer cells. J Cell Physiol. 2007;213:528-39 pubmed
    ..b>Dystroglycan (DG), a non-integrin adhesion molecule, is a complex formed by two subunits, alpha- and beta-DG, which bind to ..
  3. Cerecedo D, Cisneros B, Suárez Sánchez R, Hernández González E, Galván I. beta-Dystroglycan modulates the interplay between actin and microtubules in human-adhered platelets. Br J Haematol. 2008;141:517-28 pubmed publisher
    ..Interestingly, beta-dystroglycan was found to act as an interplay protein between actin and microtubules and an additional communication between ..
  4. Cross S, Lippitt J, Mitchell A, Hollingsbury F, Balasubramanian S, Reed M, et al. Expression of beta-dystroglycan is reduced or absent in many human carcinomas. Histopathology. 2008;53:561-6 pubmed publisher
    b>Dystroglycan is an important structural and signalling protein that is expressed in most human cells...
  5. Ayalon G, Davis J, Scotland P, Bennett V. An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan. Cell. 2008;135:1189-200 pubmed publisher
    beta-dystroglycan (DG) and the dystrophin-glycoprotein complex (DGC) are localized at costameres and neuromuscular junctions in the sarcolemma of skeletal muscle...
  6. Neely J, Amiry Moghaddam M, Ottersen O, Froehner S, Agre P, Adams M. Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein. Proc Natl Acad Sci U S A. 2001;98:14108-13 pubmed
    ..coimmunoprecipitations from brain demonstrated AQP4 in association with the complex, including dystrophin, beta-dystroglycan, and syntrophin...
  7. Russo K, Di Stasio E, Macchia G, Rosa G, Brancaccio A, Petrucci T. Characterization of the beta-dystroglycan-growth factor receptor 2 (Grb2) interaction. Biochem Biophys Res Commun. 2000;274:93-8 pubmed
    The beta-dystroglycan/Grb2 interaction was investigated and a proline-rich region within beta-dystroglycan that binds Grb2-src homology 3 domains identified...
  8. Esser A, Miller M, Huang Q, Meier M, Beltran Valero de Bernabe D, Stipp C, et al. Loss of LARGE2 disrupts functional glycosylation of α-dystroglycan in prostate cancer. J Biol Chem. 2013;288:2132-42 pubmed publisher
    b>Dystroglycan (DG) is a cell surface receptor for extracellular matrix proteins and is involved in cell polarity, matrix organization, and mechanical stability of tissues...
  9. Yamada H, Shimizu T, Tanaka T, Campbell K, Matsumura K. Dystroglycan is a binding protein of laminin and merosin in peripheral nerve. FEBS Lett. 1994;352:49-53 pubmed
    alpha-Dystroglycan, a 156 kDa dystrophin-associated glycoprotein, binds laminin in skeletal muscle. Here we demonstrate that alpha-dystroglycan is a binding protein of laminin (A/B1/B2) and merosin (M/B1/B2) in peripheral nerve...

More Information

Publications86

  1. Matsumura K, Chiba A, Yamada H, Fukuta Ohi H, Fujita S, Endo T, et al. A role of dystroglycan in schwannoma cell adhesion to laminin. J Biol Chem. 1997;272:13904-10 pubmed
    b>Dystroglycan is encoded by a single gene and cleaved into two proteins alpha- and beta-dystroglycan by posttranslational processing...
  2. Sherman D, Fabrizi C, Gillespie C, Brophy P. Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy. Neuron. 2001;30:677-87 pubmed
    b>Dystroglycan-dystrophin complexes are believed to have structural and signaling functions by linking extracellular matrix proteins to the cytoskeleton and cortical signaling molecules...
  3. Gee S, Montanaro F, Lindenbaum M, Carbonetto S. Dystroglycan-alpha, a dystrophin-associated glycoprotein, is a functional agrin receptor. Cell. 1994;77:675-86 pubmed
    ..Structural similarities shared by agrin and laminin suggested that the laminin receptor dystroglycan-alpha, part of a dystrophin-receptor complex, might also bind agrin...
  4. Michele D, Barresi R, Kanagawa M, Saito F, Cohn R, Satz J, et al. Post-translational disruption of dystroglycan-ligand interactions in congenital muscular dystrophies. Nature. 2002;418:417-22 pubmed
    ..Here we show, in both MEB and FCMD patients, that alpha-dystroglycan is expressed at the muscle membrane, but similar hypoglycosylation in the diseases directly abolishes binding ..
  5. Cao W, Henry M, Borrow P, Yamada H, Elder J, Ravkov E, et al. Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus. Science. 1998;282:2079-81 pubmed
    ..Tryptic peptides from this protein were determined to be alpha-dystroglycan (alpha-DG)...
  6. Sharma P, Ghavami S, Stelmack G, McNeill K, Mutawe M, Klonisch T, et al. beta-Dystroglycan binds caveolin-1 in smooth muscle: a functional role in caveolae distribution and Ca2+ release. J Cell Sci. 2010;123:3061-70 pubmed publisher
    ..Caveolin-1 and beta-dystroglycan, the core transmembrane DGC subunit, colocalize in airway smooth muscle...
  7. Jiang X, Rieder S, Giese N, Friess H, Michalski C, Kleeff J. Reduced ?-dystroglycan expression correlates with shortened patient survival in pancreatic cancer. J Surg Res. 2011;171:120-6 pubmed publisher
    Deregulation of cell-matrix interactions is considered an important factor in malignant transformation. Dystroglycan forms the interface between the basement membrane and the cell membrane in epithelia by its two subunits, ?- and ?-..
  8. McDearmon E, Combs A, Sekiguchi K, Fujiwara H, Ervasti J. Brain alpha-dystroglycan displays unique glycoepitopes and preferential binding to laminin-10/11. FEBS Lett. 2006;580:3381-5 pubmed
    alpha-Dystroglycan was quantitatively enriched from mammalian brain based on its uniform reactivity with Vicia villosa agglutinin and resolved into sub-populations possessing or lacking the sulfated glucuronic acid epitope recognized by ..
  9. Bao X, Kobayashi M, Hatakeyama S, Angata K, Gullberg D, Nakayama J, et al. Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferase. Proc Natl Acad Sci U S A. 2009;106:12109-14 pubmed publisher
    Alpha-dystroglycan (alpha-DG) represents a highly glycosylated cell surface molecule that is expressed in the epithelial cell-basement membrane (BM) interface and plays an essential role in epithelium development and tissue organization...
  10. Yamada H, Denzer A, Hori H, Tanaka T, Anderson L, Fujita S, et al. Dystroglycan is a dual receptor for agrin and laminin-2 in Schwann cell membrane. J Biol Chem. 1996;271:23418-23 pubmed
    We have shown previously that alpha-dystroglycan with a molecular mass of 120 kDa is a Schwann cell receptor of laminin-2, the endoneurial isoform of laminin comprised of the alpha2, beta1, and gamma1 chains...
  11. Rambukkana A, Yamada H, Zanazzi G, Mathus T, Salzer J, Yurchenco P, et al. Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae. Science. 1998;282:2076-9 pubmed
    alpha-Dystroglycan (alpha-DG) is a component of the dystroglycan complex, which is involved in early development and morphogenesis and in the pathogenesis of muscular dystrophies...
  12. Tian M, Jacobson C, Gee S, Campbell K, Carbonetto S, Jucker M. Dystroglycan in the cerebellum is a laminin alpha 2-chain binding protein at the glial-vascular interface and is expressed in Purkinje cells. Eur J Neurosci. 1996;8:2739-47 pubmed
    b>Dystroglycan is a core component of the dystrophin receptor complex in skeletal muscle which links the extracellular matrix to the muscle cytoskeleton...
  13. Oppizzi M, Akhavan A, Singh M, Fata J, Muschler J. Nuclear translocation of beta-dystroglycan reveals a distinctive trafficking pattern of autoproteolyzed mucins. Traffic. 2008;9:2063-72 pubmed publisher
    b>Dystroglycan (DG) is an extracellular matrix receptor implicated in muscular dystrophies and cancers...
  14. Bowe M, Mendis D, Fallon J. The small leucine-rich repeat proteoglycan biglycan binds to alpha-dystroglycan and is upregulated in dystrophic muscle. J Cell Biol. 2000;148:801-10 pubmed
    ..The alpha-/beta-dystroglycan subcomplex of the DAPC forms a critical link between the cytoskeleton and the extracellular matrix...
  15. Sotgia F, Lee H, Bedford M, Petrucci T, Sudol M, Lisanti M. Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins. Biochemistry. 2001;40:14585-92 pubmed
    beta-Dystroglycan is a ubiquitously expressed integral membrane protein that undergoes tyrosine phosphorylation in an adhesion-dependent manner...
  16. Ilsley J, Sudol M, Winder S. The interaction of dystrophin with beta-dystroglycan is regulated by tyrosine phosphorylation. Cell Signal. 2001;13:625-32 pubmed
    ..Here we show that beta-dystroglycan is tyrosine-phosphorylated in C2/C4 mouse myotubes...
  17. Lara Chacón B, de León M, Leocadio D, Gomez P, Fuentes Mera L, Martínez Vieyra I, et al. Characterization of an Importin alpha/beta-recognized nuclear localization signal in beta-dystroglycan. J Cell Biochem. 2010;110:706-17 pubmed publisher
    Beta-dystroglycan (beta-DG) is a widely expressed transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton, and thereby contributing to plasma membrane integrity and signal transduction...
  18. Yoshida Moriguchi T, Yu L, Stalnaker S, Davis S, Kunz S, Madson M, et al. O-mannosyl phosphorylation of alpha-dystroglycan is required for laminin binding. Science. 2010;327:88-92 pubmed publisher
    Alpha-dystroglycan (alpha-DG) is a cell-surface glycoprotein that acts as a receptor for both extracellular matrix proteins containing laminin-G domains and certain arenaviruses...
  19. de Bernabe D, Inamori K, Yoshida Moriguchi T, Weydert C, Harper H, Willer T, et al. Loss of alpha-dystroglycan laminin binding in epithelium-derived cancers is caused by silencing of LARGE. J Biol Chem. 2009;284:11279-84 pubmed publisher
    ..b>Dystroglycan is a membrane receptor that mediates interactions between cells and basement membranes in various epithelia...
  20. Mitchell A, Mathew G, Jiang T, Hamdy F, Cross S, Eaton C, et al. Dystroglycan function is a novel determinant of tumor growth and behavior in prostate cancer. Prostate. 2013;73:398-408 pubmed publisher
    b>Dystroglycan is a ubiquitously expressed cell adhesion molecule frequently found to be altered or reduced in adenocarcinomas, however the mechanisms or consequences of dystroglycan loss have not been studied extensively...
  21. Jung D, Yang B, Meyer J, Chamberlain J, Campbell K. Identification and characterization of the dystrophin anchoring site on beta-dystroglycan. J Biol Chem. 1995;270:27305-10 pubmed
    ..Here, we demonstrate and characterize a specific interaction between beta-dystroglycan and dystrophin...
  22. Ibraghimov Beskrovnaya O, Ervasti J, Leveille C, Slaughter C, Sernett S, Campbell K. Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix. Nature. 1992;355:696-702 pubmed
    ..156K dystrophin-associated glycoproteins (DAGs) are encoded by a single messenger RNA and the extracellular 156K DAG binds laminin...
  23. Yang B, Jung D, Motto D, Meyer J, Koretzky G, Campbell K. SH3 domain-mediated interaction of dystroglycan and Grb2. J Biol Chem. 1995;270:11711-4 pubmed
    b>Dystroglycan is a novel laminin receptor that links the extracellular matrix and sarcolemma in skeletal muscle...
  24. Shimizu H, Hosokawa H, Ninomiya H, Miner J, Masaki T. Adhesion of cultured bovine aortic endothelial cells to laminin-1 mediated by dystroglycan. J Biol Chem. 1999;274:11995-2000 pubmed
    Expression of dystroglycan (DG) by cultured bovine aortic endothelial (BAE) cells was confirmed by cDNA cloning from a BAE cDNA library, Northern blotting of mRNA, Western blotting of membrane proteins, and double immunostaining with ..
  25. James M, Nuttall A, Ilsley J, Ottersbach K, Tinsley J, Sudol M, et al. Adhesion-dependent tyrosine phosphorylation of (beta)-dystroglycan regulates its interaction with utrophin. J Cell Sci. 2000;113 ( Pt 10):1717-26 pubmed
    ..In order to investigate the role of tyrosine phosphorylation of the utrophin-dystroglycan complex we treated suspended or adherent cultures of HeLa cells with peroxyvanadate and immunoprecipitated (..
  26. Calogero A, Pavoni E, Gramaglia T, D Amati G, Ragona G, Brancaccio A, et al. Altered expression of alpha-dystroglycan subunit in human gliomas. Cancer Biol Ther. 2006;5:441-8 pubmed
    b>Dystroglycan (DG) is an integral membrane receptor of extracellular matrix proteins, composed of two subunits alpha and beta derived from a common precursor...
  27. Kanagawa M, Saito F, Kunz S, Yoshida Moriguchi T, Barresi R, Kobayashi Y, et al. Molecular recognition by LARGE is essential for expression of functional dystroglycan. Cell. 2004;117:953-64 pubmed
    Reduced ligand binding activity of alpha-dystroglycan is associated with muscle and central nervous system pathogenesis in a growing number of muscular dystrophies...
  28. Sgambato A, Migaldi M, Montanari M, Camerini A, Brancaccio A, Rossi G, et al. Dystroglycan expression is frequently reduced in human breast and colon cancers and is associated with tumor progression. Am J Pathol. 2003;162:849-60 pubmed
    b>Dystroglycan (DG) is an adhesion molecule responsible for crucial interactions between extracellular matrix and cytoplasmic compartment...
  29. Bartoli M, Ramarao M, Cohen J. Interactions of the rapsyn RING-H2 domain with dystroglycan. J Biol Chem. 2001;276:24911-7 pubmed
    ..of nicotinic acetylcholine receptors (nAChRs) and other integral and peripheral membrane proteins such as beta-dystroglycan and utrophin...
  30. Alonso Rangel L, Benítez Guerrero T, Martínez Vieyra I, Cisneros B, Martínez Tovar A, Winder S, et al. A role for dystroglycan in the pathophysiology of acute leukemic cells. Life Sci. 2017;182:1-9 pubmed publisher
    Previous reports have demonstrated that alterations or reduced expression of Dystroglycan (Dg) complex (?Dg and ?Dg subunits) are related to progression and severity of neoplastic solid tissues...
  31. Ksionda O, Melton A, Bache J, Tenhagen M, Bakker J, Harvey R, et al. RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines. Oncogene. 2016;35:3658-68 pubmed publisher
    ..In normal lymphocytes, RasGRP1 is recruited to the membrane by diacylglycerol (DAG) in a phospholipase C-γ (PLCγ)-dependent manner...
  32. Xu S, Nam S, Kim J, Das R, Choi S, Nguyen T, et al. Palmitate induces ER calcium depletion and apoptosis in mouse podocytes subsequent to mitochondrial oxidative stress. Cell Death Dis. 2015;6:e1976 pubmed publisher
    ..An inhibitor of diacylglycerol (DAG) kinase, which elevates cytosolic DAG, strongly promoted ER Ca(2+) depletion by low-dose palmitate...
  33. Kamerbeek C, Mateos M, Vallés A, Pediconi M, Barrantes F, Borroni V. Diacylglycerol levels modulate the cellular distribution of the nicotinic acetylcholine receptor. Int J Biochem Cell Biol. 2016;74:1-11 pubmed publisher
    Diacylglycerol (DAG), a second messenger involved in different cell signaling cascades, activates protein kinase C (PKC) and D (PKD), among other kinases...
  34. James A, Gowsalya R, Nachiappan V. Dolichyl pyrophosphate phosphatase-mediated N-glycosylation defect dysregulates lipid homeostasis in Saccharomyces cerevisiae. Biochim Biophys Acta. 2016;1861:1705-1718 pubmed publisher
    ..However, the TAG, SE, and LD levels were significantly reduced, and FFA, sterol, and DAG levels were increased...
  35. Beal R, Afrin T, Farheen A, Adjeroh D. A new algorithm for "the LCS problem" with application in compressing genome resequencing data. BMC Genomics. 2016;17 Suppl 4:544 pubmed publisher
    ..Using the maximal common substrings, we construct a directed acyclic graph (DAG), based on which we determine the LCS as the longest path in the DAG...
  36. Atef R, Agha A, Abdel Rhaman A, Nassar N. The Ying and Yang of Adenosine A1 and A2A Receptors on ERK1/2 Activation in a Rat Model of Global Cerebral Ischemia Reperfusion Injury. Mol Neurobiol. 2018;55:1284-1298 pubmed publisher
    ..carotid occlusion (45 min) followed by reperfusion (24 h) exhibited increased pERK1/2 activity, downstream from DAG pathway, along with increases in hippocampal glutamate, c-Fos, NF-κB, TNF-α, iNOS, TBARS, cytochrome c, caspase-3,..
  37. Polewski M, Burhans M, Zhao M, Colman R, Shanmuganayagam D, Lindstrom M, et al. Plasma diacylglycerol composition is a biomarker of metabolic syndrome onset in rhesus monkeys. J Lipid Res. 2015;56:1461-70 pubmed publisher
    ..Plasma fatty acid composition was determined by gas chromatography for cholesteryl ester, FFA, diacylglycerol (DAG), phospholipid, and triacylglycerol lipid classes; plasma lipoprotein profiles were generated by NMR; and ..
  38. Chen X, Wu Q, Depeille P, Chen P, Thornton S, Kalirai H, et al. RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma. Cancer Cell. 2017;31:685-696.e6 pubmed publisher
    ..RasGRP3 activation occurs via PKC δ- and ɛ-dependent phosphorylation and PKC-independent, DAG-mediated membrane recruitment, possibly explaining the limited effect of PKC inhibitors to durably suppress MAPK in ..
  39. Westrich J, Warren C, Klausner M, Guo K, Liu C, Santiago M, et al. Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein Degradation. J Virol. 2018;92: pubmed publisher
    ..Here, we report a mechanism for the dramatic increase of A3A protein levels in HPV-positive keratinocytes...
  40. Dong M, Noguchi S, Endo Y, Hayashi Y, Yoshida S, Nonaka I, et al. DAG1 mutations associated with asymptomatic hyperCKemia and hypoglycosylation of α-dystroglycan. Neurology. 2015;84:273-9 pubmed publisher
    ..Both mutations were in the N-terminal region of α-dystroglycan and affected its glycosylation...
  41. Zhang X, Dong X, Ma Y, Li L, Wu H, Zhou M, et al. Reduction of ?-dystroglycan expression is correlated with poor prognosis in glioma. Tumour Biol. 2014;35:11621-9 pubmed publisher
    b>Dystroglycan (DG), a multifunctional protein dimer of non-covalently linked ? and ? subunits, is best known as an adhesion and transduction molecule linking the cytoskeleton and intracellular signaling pathways to extracellular matrix ..
  42. Brockington M, Torelli S, Sharp P, Liu K, Cirak S, Brown S, et al. Transgenic overexpression of LARGE induces α-dystroglycan hyperglycosylation in skeletal and cardiac muscle. PLoS ONE. 2010;5:e14434 pubmed publisher
    ..enzymes defective in a common group of muscular dystrophies with reduced glycosylation of α-dystroglycan. Overexpression of LARGE induces hyperglycosylation of α-dystroglycan in both wild type and in cells from ..
  43. Arumugam V, Bluemn T, Wesley E, Schmidt A, Kambayashi T, Malarkannan S, et al. TCR signaling intensity controls CD8+ T cell responsiveness to TGF-β. J Leukoc Biol. 2015;98:703-12 pubmed publisher
    DGK-ζ is a negative regulator of TCR signaling that causes degradation of the second messenger DAG, terminating DAG-mediated activation of Ras and PKCθ...
  44. Sato N. Is Monoglucosyldiacylglycerol a Precursor to Monogalactosyldiacylglycerol in All Cyanobacteria?. Plant Cell Physiol. 2015;56:1890-9 pubmed publisher
    ..It is synthesized by galactosylation of diacylglycerol (DAG) in the chloroplasts, whereas it is produced by epimerization of monoglucosyldiacylglycerol (GlcDG) in at least ..
  45. McNally R, Heeren A, Robinaugh D. A Bayesian network analysis of posttraumatic stress disorder symptoms in adults reporting childhood sexual abuse. Eur J Psychotraumatol. 2017;8:1341276 pubmed publisher
    ..Next, using a Bayesian approach, we computed a directed acyclic graph (DAG) to estimate a directed, potentially causal model of the relations among symptoms...
  46. Harasiuk D, Baranowski M, Zabielski P, Chabowski A, Gorski J. Liver X Receptor Agonist TO901317 Prevents Diacylglycerols Accumulation in the Heart of Streptozotocin-Diabetic Rats. Cell Physiol Biochem. 2016;39:350-9 pubmed publisher
    ..On the contrary, myocardial level of cholesterol and diacylglycerols (DAG) was decreased after LXR activation in diabetic rats, the change in DAG level was associated with downregulated ..
  47. Bhattacharya S, Das A, Ghosh S, Dasgupta R, Bagchi A. Hypoglycosylation of dystroglycan due to T192M mutation: a molecular insight behind the fact. Gene. 2014;537:108-14 pubmed publisher
    Abnormal glycosylation of dystroglycan (DG), a transmembrane glycoprotein, results in a group of diseases known as dystroglycanopathy...
  48. Sgambato A, Camerini A, Amoroso D, Genovese G, De Luca F, Cecchi M, et al. Expression of dystroglycan correlates with tumor grade and predicts survival in renal cell carcinoma. Cancer Biol Ther. 2007;6:1840-6 pubmed
    The dystroglycan (DG) complex is a transmembrane glycoprotein that forms a continuous link from the extracellular matrix to the actin cytoskeleton...
  49. Li L, Wang F, Yan P, Jing W, Zhang C, Kudla J, et al. A phosphoinositide-specific phospholipase C pathway elicits stress-induced Ca2+ signals and confers salt tolerance to rice. New Phytol. 2017;214:1172-1187 pubmed publisher
    ..phosphatidylinositol-4,5-biphosphates [PtdIns(4,5)P2 ] into the second messengers diacylglycerol (DAG) and inositol 1,4,5-trisphosphate [Ins(1,4,5)P3 ] to regulate diverse biological processes...
  50. Serup A, Alsted T, Jordy A, Schjerling P, Holm C, Kiens B. Partial Disruption of Lipolysis Increases Postexercise Insulin Sensitivity in Skeletal Muscle Despite Accumulation of DAG. Diabetes. 2016;65:2932-42 pubmed publisher
    ..insulin resistance have been linked to accumulation of the intramyocellular lipid-intermediate diacylglycerol (DAG). However, recent animal and human studies have questioned such an association...
  51. Jaguva Vasudevan A, Goering W, Haussinger D, Munk C. Detection of APOBEC3 Proteins and Catalytic Activity in Urothelial Carcinoma. Methods Mol Biol. 2018;1655:97-107 pubmed publisher
    ..Immunodetection of APOBEC3A (A3A), APOBEC3B (A3B), and APOBEC3G (A3G) proteins is particularly challenging due to the large sequence homology of ..
  52. Huang X, Poy F, Zhang R, Joachimiak A, Sudol M, Eck M. Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan. Nat Struct Biol. 2000;7:634-8 pubmed
    Dystrophin and beta-dystroglycan are components of the dystrophin-glycoprotein complex (DGC), a multimolecular assembly that spans the cell membrane and links the actin cytoskeleton to the extracellular basal lamina...
  53. Chang W, Chen L, Hatch G. Berberine treatment attenuates the palmitate-mediated inhibition of glucose uptake and consumption through increased 1,2,3-triacyl-sn-glycerol synthesis and accumulation in H9c2 cardiomyocytes. Biochim Biophys Acta. 2016;1861:352-62 pubmed publisher
    Dysfunction of lipid metabolism and accumulation of 1,2-diacyl-sn-glycerol (DAG) may be a key factor in the development of insulin resistance in type 2 diabetes...
  54. Wang Y, Lee G, Huang Y, Kuo C. sn-1,2-diacylglycerols protect against lethal endotoxemia by controlling systemic inflammation. Immunobiology. 2016;221:1309-18 pubmed publisher
    ..Despite substantial evidence supporting the role of diacylglycerols (DAG) in modulating chronic inflammation and chronic diseases, the potential mechanisms of its involvement in TLRs-..
  55. Morgan A, Han D, Lam W, Fraser A, Ferguson L. Association analysis of 3p21 with Crohn's disease in a New Zealand population. Hum Immunol. 2010;71:602-9 pubmed publisher
    ..The results from this study support the accumulating evidence that suggests the 3p21 region is a CD-associated locus, although it remains unclear which is the causative SNP and/or gene. ..
  56. Van den Bergh P, Sznajer Y, Van Parys V, van Tol W, Wevers R, Lefeber D, et al. A homozygous DPM3 mutation in a patient with alpha-dystroglycan-related limb girdle muscular dystrophy. Neuromuscul Disord. 2017;27:1043-1046 pubmed publisher
    Defects of O-linked glycosylation of alpha-dystroglycan cause a wide spectrum of muscular dystrophies ranging from severe congenital muscular dystrophy associated with abnormal brain and eye development to mild limb girdle muscular ..
  57. Bustos Morán E, Blas Rus N, Martin Cófreces N, Sánchez Madrid F. Microtubule-associated protein-4 controls nanovesicle dynamics and T cell activation. J Cell Sci. 2017;130:1217-1223 pubmed publisher
    ..However, MAP4 acts as a negative regulator of other T cell activation-related signals, including diacylglycerol (DAG) production and IL2 secretion...
  58. Saito F, Saito Arai Y, Nakamura A, Shimizu T, Matsumura K. Processing and secretion of the N-terminal domain of alpha-dystroglycan in cell culture media. FEBS Lett. 2008;582:439-44 pubmed publisher
    Alpha-dystroglycan (alpha-DG) plays a crucial role in maintaining the stability of muscle cell membrane...
  59. Nomura W, Ito Y, Inoue Y. Role of phosphatidylserine in the activation of Rho1-related Pkc1 signaling in Saccharomyces cerevisiae. Cell Signal. 2017;31:146-153 pubmed publisher
    ..Diacylglycerol (DAG) and phorbol esters bind to the C1 domain to enhance its kinase activity...
  60. Yang Z, Kim S, Mahajan S, Zamani A, Faccio R. Phospholipase C?1 (PLC?1) Controls Osteoclast Numbers via Colony-stimulating Factor 1 (CSF-1)-dependent Diacylglycerol/?-Catenin/CyclinD1 Pathway. J Biol Chem. 2017;292:1178-1186 pubmed publisher
    ..modulating a variety of cellular pathways through production of inositol 1,4,5-trisphosphate and diacylglycerol (DAG)...
  61. Tham D, Joshi B, Moukhles H. Aquaporin-4 Cell-Surface Expression and Turnover Are Regulated by Dystroglycan, Dynamin, and the Extracellular Matrix in Astrocytes. PLoS ONE. 2016;11:e0165439 pubmed publisher
    ..We had previously established that this polarization was regulated by the interaction between dystroglycan (DG), an extracellular matrix receptor that is co-expressed with AQP4, and the laminin that is contained within ..
  62. Hua Y, Zhang D, Zhou T, He M, Ding G, Shi L, et al. Transcriptomics-assisted quantitative trait locus fine mapping for the rapid identification of a nodulin 26-like intrinsic protein gene regulating boron efficiency in allotetraploid rapeseed. Plant Cell Environ. 2016;39:1601-18 pubmed publisher
    ..gene expression (DGE) profiling were combined to identify the candidate genes underlying the major-effect QTL qBEC-A3a, which regulates B efficiency...
  63. Morava E, Willemsen M, Wopereis S, ter Laak H, Lefeber D, Wevers R, et al. High myopia and congenital myopathy with partial pachygyria in cutis laxa syndrome. Eur J Ophthalmol. 2006;16:190-4 pubmed
    ..biosynthesis defects commonly present as a severe form of congenital muscular dystrophy with decreased alpha-dystroglycan staining, congenital eye anomalies, and brain migration defects...
  64. Lord C, Ferguson D, Thomas G, Brown A, Schugar R, Burrows A, et al. Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation. Cell Rep. 2016;16:939-949 pubmed publisher
    ..CGI-58 also regulates hepatic diacylglycerol (DAG) and inflammation in an ATGL-independent manner...
  65. Bozzi M, Veglia G, Paci M, Sciandra F, Giardina B, Brancaccio A. A synthetic peptide corresponding to the 550-585 region of alpha-dystroglycan binds beta-dystroglycan as revealed by NMR spectroscopy. FEBS Lett. 2001;499:210-4 pubmed
    We have probed the binding of a synthetic peptide corresponding to the region 550-585 of the alpha subunit of dystroglycan with a recombinant protein fragment corresponding to the N-terminal extracellular region of beta-dystroglycan (654-..
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    ..We identified a cyclic peptide, CDAGRKQKC (DAG), that accumulates in the hippocampus of hAPP-J20 mice at different ages...
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    Multiple glycosyltransferases are essential for the proper modification of alpha-dystroglycan, as mutations in the encoding genes cause congenital/limb-girdle muscular dystrophies...
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    ..We demonstrated a direct protein interaction between MLC1 and Kir4.1. From these results we conclude that MLC1 is associated with the DGC at astrocytic endfeet...
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    ..The STZ and HFD rats had increased concentration of lipids, namely, ceramides (CER) and diacylglycerols (DAG)...
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    Altered glycosylation and/or expression of dystroglycan have been reported in forms of congenital muscular dystrophy as well as in cancers of the breast, colon, and oral epithelium...
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    ..Metformin and resveratrol reduced FFAs influx and DAG accumulation, and thus improved insulin signaling in the muscle by inhibiting PKC? translocation...
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    ..Lipidomic analysis shows a marked increase of diacylglycerol (DAG) and phosphatidic acid, the precursors for TAG, in the mutant during mitotic exit...
  74. Marchese M, Pappalardo A, Baldacci J, Verri T, Doccini S, Cassandrini D, et al. Dolichol-phosphate mannose synthase depletion in zebrafish leads to dystrophic muscle with hypoglycosylated α-dystroglycan. Biochem Biophys Res Commun. 2016;477:137-143 pubmed publisher
    ..DPMS) complex is a rare cause of congenital muscular dystrophy associated with hypoglycosylation of alpha-dystroglycan (α-DG) in skeletal muscle...
  75. Ogawa M, Nakamura N, Nakayama Y, Kurosaka A, Manya H, Kanagawa M, et al. GTDC2 modifies O-mannosylated ?-dystroglycan in the endoplasmic reticulum to generate N-acetyl glucosamine epitopes reactive with CTD110.6 antibody. Biochem Biophys Res Commun. 2013;440:88-93 pubmed publisher
    ..6 antibody-reactive N-acetylglucosamine (GlcNAc) epitopes on the O-mannosylated ?-dystroglycan (?-DG)...
  76. Roelants F, Leskoske K, Martinez Marshall M, Locke M, Thorner J. The TORC2-Dependent Signaling Network in the Yeast Saccharomyces cerevisiae. Biomolecules. 2017;7: pubmed publisher
    ..but, in addition, by interaction with Rho1-GTP and lipids phosphatidylserine (PtdSer) and diacylglycerol (DAG)...
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    b>Dystroglycan (DG) is an extracellular matrix receptor that serves as an adhesion molecule and is essential for the stability of the plasma membrane...