Dab2

Summary

Gene Symbol: Dab2
Description: DAB2, clathrin adaptor protein
Alias: DOC-2, DOC2, disabled homolog 2, Dab, mitogen-responsive phosphoprotein, homolog 2, adaptor molecule disabled-2, differentially expressed in ovarian carcinoma 2, differentially-expressed protein 2, disabled homolog 2, mitogen-responsive phosphoprotein
Species: human
Products:     Dab2

Top Publications

  1. Gallagher H, Oleinikov A, Fenske C, Newman D. The adaptor disabled-2 binds to the third psi xNPxY sequence on the cytoplasmic tail of megalin. Biochimie. 2004;86:179-82 pubmed
    ..One such interaction is with the phosphotyrosine interaction domain (PID) of the adaptor protein disabled-2 (Dab2), a mitogen-responsive phosphoprotein, which interacts via its PID with Psi xNPxY (where Psi represents a ..
  2. Wang Z, Tseng C, Pong R, Chen H, McConnell J, Navone N, et al. The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2. J Biol Chem. 2002;277:12622-31 pubmed
    DOC-2/DAB2 is a member of the disable gene family with tumor-inhibitory activity...
  3. Huang C, Cheng J, Liao C, Stern A, Hsieh J, Wang C, et al. Disabled-2 is a negative regulator of integrin alpha(IIb)beta(3)-mediated fibrinogen adhesion and cell signaling. J Biol Chem. 2004;279:42279-89 pubmed
    Disabled-2 (DAB2) is an adapter protein that is up-reg-ulated during megakaryocytic differentiation of hematopoietic cells and is abundantly expressed in platelets...
  4. Sahlender D, Roberts R, Arden S, Spudich G, Taylor M, Luzio J, et al. Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis. J Cell Biol. 2005;169:285-95 pubmed
    ..These results show that optineurin links myosin VI to the Golgi complex and plays a central role in Golgi ribbon formation and exocytosis. ..
  5. Aschenbrenner L, Lee T, Hasson T. Myo6 facilitates the translocation of endocytic vesicles from cell peripheries. Mol Biol Cell. 2003;14:2728-43 pubmed
  6. Keyel P, Mishra S, Roth R, Heuser J, Watkins S, Traub L. A single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptors. Mol Biol Cell. 2006;17:4300-17 pubmed
    ..cytosolic domain of the LDL receptor is recognized redundantly by two phosphotyrosine-binding domain proteins, Dab2 and ARH; diminishing both proteins by RNAi leads to conspicuous LDL receptor accumulation at the cell surface...
  7. Calderwood D, Fujioka Y, de Pereda J, García Alvarez B, Nakamoto T, Margolis B, et al. Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc Natl Acad Sci U S A. 2003;100:2272-7 pubmed
    ..These data establish that short integrin beta tails interact with a large number of PTB domain-containing proteins through a structurally conserved mechanism. ..
  8. Maurer M, Cooper J. The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH. J Cell Sci. 2006;119:4235-46 pubmed
    ..However, ARH is dispensable for LDL uptake by some other cell types. Here, we show that the adaptor Dab2 plays a major role in LDLR internalization in HeLa cells and fibroblasts...
  9. Karam J, Shariat S, Huang H, Pong R, Ashfaq R, Shapiro E, et al. Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder. Clin Cancer Res. 2007;13:4400-6 pubmed
    DOC-2/DAB2 (differentially expressed in ovarian carcinoma-2/disabled-2), a potential tumor suppressor gene, is underexpressed in several cancers...

More Information

Publications82

  1. Cihil K, Ellinger P, Fellows A, Stolz D, Madden D, Swiatecka Urban A. Disabled-2 protein facilitates assembly polypeptide-2-independent recruitment of cystic fibrosis transmembrane conductance regulator to endocytic vesicles in polarized human airway epithelial cells. J Biol Chem. 2012;287:15087-99 pubmed publisher
    ..Disabled-2 (Dab2) is a clathrin-associated sorting protein (CLASP) that contributes to clathrin recruitment, vesicle formation, and ..
  2. Orlandini M, Nucciotti S, Galvagni F, Bardelli M, Rocchigiani M, Petraglia F, et al. Morphogenesis of human endothelial cells is inhibited by DAB2 via Src. FEBS Lett. 2008;582:2542-8 pubmed publisher
    Disabled-2 (DAB2) is an adaptor protein implicated in signal transduction pathways and in protein traffic regulation. Here, we show that DAB2 is highly expressed in human endothelial cells...
  3. Morris S, Cooper J. Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2. Traffic. 2001;2:111-23 pubmed
    Disabled-2 (Dab2) is a widely expressed relative of Disabled-1, a neuron-specific signal-transduction protein that binds to and receives signals from members of the low-density lipoprotein receptor (LDLR) family...
  4. Sheng Z, He J, Tuppen J, Sun W, Fazili Z, Smith E, et al. Structure, sequence, and promoter analysis of human disabled-2 gene (DAB2). Genomics. 2000;70:381-6 pubmed
    Disabled-2 (DAB2 for human and Dab2 for other species) is one of two mammalian orthologues of Drosophila Disabled...
  5. Jain N, Nguyen H, Friedline R, Malhotra N, Brehm M, Koyanagi M, et al. Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function. J Immunol. 2009;183:4192-6 pubmed publisher
    ..In this study we show that in mouse peripheral lymphocytes the Drosophila Disabled-2 (Dab2) homolog, a gene that is involved in enhancing TGFbeta responses, is exclusively expressed in FOXP3+ regulatory T ..
  6. Hannigan A, Smith P, Kalna G, Lo Nigro C, Orange C, O Brien D, et al. Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter. J Clin Invest. 2010;120:2842-57 pubmed publisher
    ..Here we demonstrate that downregulation of disabled homolog 2 (DAB2) gene expression via promoter methylation frequently occurs in human squamous cell carcinomas (SCCs) ..
  7. Martin J, Herbert B, Hocevar B. Disabled-2 downregulation promotes epithelial-to-mesenchymal transition. Br J Cancer. 2010;103:1716-23 pubmed publisher
    ..Disabled-2 (Dab2) is a putative tumour suppressor whose expression has been shown to be downregulated in various cancer types ..
  8. Spudich G, Chibalina M, Au J, Arden S, Buss F, Kendrick Jones J. Myosin VI targeting to clathrin-coated structures and dimerization is mediated by binding to Disabled-2 and PtdIns(4,5)P2. Nat Cell Biol. 2007;9:176-83 pubmed
    ..tail is the key targeting region and have identified three binding sites: a WWY motif for Disabled-2 (Dab2) binding, a RRL motif for glucose-transporter binding protein (GIPC) and optineurin binding and a site that binds ..
  9. Anupam K, Tusharkant C, Gupta S, Ranju R. Loss of disabled-2 expression is an early event in esophageal squamous tumorigenesis. World J Gastroenterol. 2006;12:6041-5 pubmed
    Disabled-2 (DAB2) is a candidate tumor-suppressor gene identified in ovarian cancer that negatively influences mitogenic signal transduction of growth factors and blocks ras activity...
  10. Mulkearns E, Cooper J. FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis. Mol Biol Cell. 2012;23:1330-42 pubmed publisher
    ..Clathrin and endocytic accessory proteins are recruited to receptors by specific adaptors. The adaptor Disabled-2 (Dab2) recruits its cargoes, including the low-density lipoprotein receptor (LDLR), and mediates endocytosis, even when ..
  11. Chetrit D, Barzilay L, Horn G, Bielik T, Smorodinsky N, Ehrlich M. Negative regulation of the endocytic adaptor disabled-2 (Dab2) in mitosis. J Biol Chem. 2011;286:5392-403 pubmed publisher
    ..Disabled 2 (Dab2), a multidomain cargo-specific endocytic adaptor and a mediator of signal transduction, is a potential integrator ..
  12. Zhoul J, Hernandez G, Tu S, Huang C, Tseng C, Hsieh J. The role of DOC-2/DAB2 in modulating androgen receptor-mediated cell growth via the nongenomic c-Src-mediated pathway in normal prostatic epithelium and cancer. Cancer Res. 2005;65:9906-13 pubmed
    ..We describe a unique protein-DOC-2/DAB2 (differentially expressed in ovarian cancer-2/disabled 2)-that antagonizes androgen receptor-mediated cell growth ..
  13. Henne W, Boucrot E, Meinecke M, Evergren E, Vallis Y, Mittal R, et al. FCHo proteins are nucleators of clathrin-mediated endocytosis. Science. 2010;328:1281-4 pubmed publisher
    ..The FCHo F-BAR membrane-bending activity was required, leading to the proposal that FCHo1/2 sculpt the initial bud site and recruit the clathrin machinery for CCV formation. ..
  14. Kowanetz K, Terzic J, Dikic I. Dab2 links CIN85 with clathrin-mediated receptor internalization. FEBS Lett. 2003;554:81-7 pubmed
    ..Here we show that disabled-2 (Dab2), an endocytic adaptor molecule implicated in clathrin-coat assembly, associates with CIN85 in mammalian cells...
  15. Sun W, Smith E, Cohen C, Sheng Z, Xu X. Restoration of positioning control following Disabled-2 expression in ovarian and breast tumor cells. Oncogene. 2000;19:4847-54 pubmed
    ..the majority of breast and ovarian carcinomas (85-90%), the expression of a candidate tumor suppressor, Disabled-2 (Dab2), is frequently lost...
  16. Zhou J, Scholes J, Hsieh J. Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer. J Biol Chem. 2003;278:6936-41 pubmed
    DOC-2/DAB2 is a potent tumor suppressor in many cancer types including prostate cancer. In prostate cancer, expression of DOC-2/DAB2 can inhibit its growth...
  17. Hocevar B, Smine A, Xu X, Howe P. The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway. EMBO J. 2001;20:2789-801 pubmed
    Using a genetic complementation approach we have identified disabled-2 (Dab2), a structural homolog of the Dab1 adaptor molecule, as a critical link between the transforming growth factor beta (TGFbeta) receptors and the Smad family of ..
  18. Mok S, Wong K, Chan R, Lau C, Tsao S, Knapp R, et al. Molecular cloning of differentially expressed genes in human epithelial ovarian cancer. Gynecol Oncol. 1994;52:247-52 pubmed
    ..Only the antisense DOC-2 riboprobe revealed a hybridization signal which was restricted to the human surface ovarian epithelium. The potential functional roles of these genes is now under investigation. ..
  19. Morris S, Tallquist M, Rock C, Cooper J. Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport. EMBO J. 2002;21:1555-64 pubmed
    The Disabled-2 (Dab2) gene has been proposed to act as a tumor suppressor. Cell culture studies have implicated Dab2 in signal transduction by mitogens, TGFbeta and endocytosis of lipoprotein receptors...
  20. Tong J, Ng D, Chau S, So K, Leung P, Lee T, et al. Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma. BMC Cancer. 2010;10:253 pubmed publisher
    Human disabled-2 (DAB2), is a multi-function signalling molecule that it is frequently down-regulated in human cancers. We aimed to investigate the possible tumour suppressor effect of DAB2 in nasopharyngeal carcinoma (NPC)...
  21. Xu X, Yi T, Tang B, Lambeth J. Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2. Oncogene. 1998;16:1561-9 pubmed
    Disabled-2 (Dab2), a mammalian structural homolog of Drosophila Disabled (Dab), is a mitogen-responsive phosphoprotein. It has been speculated to be a negative regulator of growth since its expression is lost in ovarian carcinomas...
  22. Mok S, Chan W, Wong K, Cheung K, Lau C, Ng S, et al. DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer. Oncogene. 1998;16:2381-7 pubmed
    ..These data suggest that down-regulation of DOC-2 may play an important role in ovarian carcinogenesis. ..
  23. Fazili Z, Sun W, Mittelstaedt S, Cohen C, Xu X. Disabled-2 inactivation is an early step in ovarian tumorigenicity. Oncogene. 1999;18:3104-13 pubmed
    Disabled-2 (Dab2) functions in mitogenic signal transduction pathway, and is frequently activated by homozygous gene deletion in tumors, suggesting that Dab2 is a candidate tumor suppressor...
  24. Teckchandani A, Toida N, Goodchild J, Henderson C, Watts J, Wollscheid B, et al. Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. J Cell Biol. 2009;186:99-111 pubmed publisher
    ..unbiased quantitative proteomics approach to identify and quantify glycoprotein cargoes for an endocytic adapter, Dab2. Surface levels of integrins beta1, alpha1, alpha2, and alpha3 but not alpha5 or alphav chains were specifically ..
  25. Zhou J, Hsieh J. The inhibitory role of DOC-2/DAB2 in growth factor receptor-mediated signal cascade. DOC-2/DAB2-mediated inhibition of ERK phosphorylation via binding to Grb2. J Biol Chem. 2001;276:27793-8 pubmed
    DOC-2/DAB2 (differentially expressed in ovarian carcinoma-2/disabled 2) appears to be a potential tumor suppressor gene with a growth inhibitory effect on several cancer types...
  26. Bagadi S, Prasad C, Srivastava A, Prashad R, Gupta S, Ralhan R. Frequent loss of Dab2 protein and infrequent promoter hypermethylation in breast cancer. Breast Cancer Res Treat. 2007;104:277-86 pubmed
    Disabled-2 (Dab2), a putative tumor suppressor protein, is lost in 80-90% ovarian tumors and ovarian/breast cancer cell lines. The clinical significance of Dab2 protein in breast cancer remains yet unknown...
  27. Morris S, Arden S, Roberts R, Kendrick Jones J, Cooper J, Luzio J, et al. Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton. Traffic. 2002;3:331-41 pubmed
    Myosin VI, an actin-based motor protein, and Disabled 2 (Dab2), a molecule involved in endocytosis and cell signalling, have been found to bind together using yeast and mammalian two-hybrid screens...
  28. Hocevar B, Mou F, Rennolds J, Morris S, Cooper J, Howe P. Regulation of the Wnt signaling pathway by disabled-2 (Dab2). EMBO J. 2003;22:3084-94 pubmed
    The adaptor molecule Disabled-2 (Dab2) has been shown to link cell surface receptors to downstream signaling pathways...
  29. He J, Xu J, Xu X, Hall R. Cell cycle-dependent phosphorylation of Disabled-2 by cdc2. Oncogene. 2003;22:4524-30 pubmed
    Disabled-2 (Dab2; also known as p96 and DOC-2) is a signal transduction protein that has been implicated in the control of cell growth. Dab2 is known to be a phosphoprotein, but little is known about the kinases that phosphorylate Dab2...
  30. Hocevar B, Prunier C, Howe P. Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway. J Biol Chem. 2005;280:25920-7 pubmed
    ..We show here that the cytosolic adaptor protein disabled-2 (Dab2) directly stimulates JNK activity, whereas stable small interfering RNA-mediated ablation of Dab2 in NIH3T3 mouse ..
  31. Prunier C, Howe P. Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT). J Biol Chem. 2005;280:17540-8 pubmed
    ..Here, we have demonstrated that TGFbeta induces the expression of the adaptor molecule disabled-2 (Dab2) concomitant with the promotion of EMT...
  32. Yang C, He H, Zhang T, Chen Y, Kong Z. Decreased DAB2IP gene expression, which could be induced by fractionated irradiation, is associated with resistance to ??rays and ??particles in prostate cancer cells. Mol Med Rep. 2016;14:567-73 pubmed publisher
    ..Treatment with KU55933 did not enhance cell sensitivity to ??irradiation. Therefore, this suggested that DAB2IP downregulation induced by radiotherapy may be associated with acquired radioresistance in patients with PCa. ..
  33. Adamson S, Polanowska Grabowska R, Marqueen K, Griffiths R, Angdisen J, Breevoort S, et al. Deficiency of Dab2 (Disabled Homolog 2) in Myeloid Cells Exacerbates Inflammation in Liver and Atherosclerotic Plaques in LDLR (Low-Density Lipoprotein Receptor)-Null Mice-Brief Report. Arterioscler Thromb Vasc Biol. 2018;38:1020-1029 pubmed publisher
    ..We have identified the adaptor protein Dab2 (disabled homolog 2) as a regulator of phenotypic polarization in macrophages...
  34. Lau A, Kollara A, St John E, Tone A, Virtanen C, Greenblatt E, et al. Altered expression of inflammation-associated genes in oviductal cells following follicular fluid exposure: implications for ovarian carcinogenesis. Exp Biol Med (Maywood). 2014;239:24-32 pubmed publisher
    ..and decreased the expression of mitochondrial superoxide dismutase (SOD2), glutathione peroxidase 3 (GPX3), disabled homolog 2 (DAB2), and glucocorticoid receptor (NR3C1)...
  35. Hofsteen P, Robitaille A, Chapman D, Moon R, Murry C. Quantitative proteomics identify DAB2 as a cardiac developmental regulator that inhibits WNT/β-catenin signaling. Proc Natl Acad Sci U S A. 2016;113:1002-7 pubmed publisher
    ..We identified Disabled 2 (DAB2) as one of the most dynamically expressed proteins in hESCs, CPCs, and cardiomyocytes...
  36. Li S, Zhai J, Liu J, Hong Y, Zhao W, Zhao A, et al. BMAL1 facilitates trophoblast migration and invasion via SP1-DNMT1/DAB2IP pathway in recurrent spontaneous abortion. Oncotarget. 2017;8:89451-89464 pubmed publisher
    ..Using HTR-8/SVneo and JEG-3 cell lines, we certified the induction of specificity protein 1 (SP1) to DNMT1 and DAB2 interaction protein (DAB2IP), respectively, both of which further activated matrix metallo-proteinase 2/9 (MMP2/9), ..
  37. Puri C, Chibalina M, Arden S, Kruppa A, Kendrick Jones J, Buss F. Overexpression of myosin VI in prostate cancer cells enhances PSA and VEGF secretion, but has no effect on endocytosis. Oncogene. 2010;29:188-200 pubmed publisher
    ..The absence of Disabled-2 (Dab2), a tumour suppressor and myosin VI-binding partner, inhibits recruitment of myosin VI to endocytic structures at ..
  38. Tao Y, Sun C, Zhang T, Song Y. SMURF1 promotes the proliferation, migration and invasion of gastric cancer cells. Oncol Rep. 2017;38:1806-1814 pubmed publisher
    ..Mechanically, SMURF1 inversely regulated the expression of DOC-2/DAB2 interactive protein (DAB2IP) in GC tissues and cells...
  39. Dong F, Patnaik S, Duan Z, Kiedrowski M, Penn M, Mayorga M. A Novel Role for CAMKK1 in the Regulation of the Mesenchymal Stem Cell Secretome. Stem Cells Transl Med. 2017;6:1759-1766 pubmed publisher
    ..We previously demonstrated that downregulation of Dab2 enhances MSC cardiac protein expression and improves cardiac function after AMI following MSC engraftment...
  40. Jou Y, Tsai Y, Chen S, Hsieh H, Tsai H, Tzai T. Loss of DAB2IP expression in human urothelial carcinoma is associated with poorer recurrence-free survival. Virchows Arch. 2016;468:733-40 pubmed publisher
    The purpose of this study is to investigate the clinical relevance of deletion of ovarian carcinoma 2/disabled homolog 2 (DOC-2/DAB2) interacting protein (DAB2IP) expression in human urothelial carcinoma (UC)...
  41. Drahos K, Welsh J, Finkielstein C, Capelluto D. Sulfatides partition disabled-2 in response to platelet activation. PLoS ONE. 2009;4:e8007 pubmed publisher
    ..One negative regulator of platelet aggregation is Disabled-2 (Dab2), which is released to the extracellular surface upon platelet activation...
  42. Wang L, Wang X, Wang L, Yousaf M, Li J, Zuo M, et al. Identification of a new adtrp1-tfpi regulatory axis for the specification of primitive myelopoiesis and definitive hematopoiesis. FASEB J. 2018;32:183-194 pubmed publisher
    ..no effect on gata1 or h-bae1) or vasculogenesis (no effect on kdrl, ephb2a, notch3, dab2, or flt4). Knockdown of adtrp2 expression does not have apparent effects on all markers tested...
  43. Wang B, Gu Q, Li J. DOC-2/DAB2 interactive protein regulates proliferation and mobility of nasopharyngeal carcinoma cells by targeting PI3K/Akt pathway. Oncol Rep. 2017;38:317-324 pubmed publisher
    ..DOC-2/DAB2 interactive protein (DAB2IP) has been found to be a novel tumor suppressor in malignancies...
  44. Strady E, Dang V, Némery J, Guedron S, Dinh Q, Denis H, et al. Baseline seasonal investigation of nutrients and trace metals in surface waters and sediments along the Saigon River basin impacted by the megacity of Ho Chi Minh (Vietnam). Environ Sci Pollut Res Int. 2017;24:3226-3243 pubmed publisher
    ..g., for As and Cr) and pH (e.g., for Pb) which drives their sorption/dissolution dynamics. ..
  45. Shapira K, Hirschhorn T, Barzilay L, Smorodinsky N, Henis Y, Ehrlich M. Dab2 inhibits the cholesterol-dependent activation of JNK by TGF-?. Mol Biol Cell. 2014;25:1620-8 pubmed publisher
    ..The tumor suppressor/endocytic adaptor protein disabled-2 (Dab2) was proposed as a modulator of TGF-? signaling...
  46. Wagner M, Campos Bilderback S, Chowdhury M, Flores B, Lai X, Myslinski J, et al. Proximal Tubules Have the Capacity to Regulate Uptake of Albumin. J Am Soc Nephrol. 2016;27:482-94 pubmed publisher
    ..and pathways affected by acute protein overload, revealed changes in the expression levels of calreticulin, disabled homolog 2, NRF2, angiopoietin-2, and proteins involved in ATP synthesis...
  47. Valentino E, Bellazzo A, Di Minin G, Sicari D, Apollonio M, Scognamiglio G, et al. Mutant p53 potentiates the oncogenic effects of insulin by inhibiting the tumor suppressor DAB2IP. Proc Natl Acad Sci U S A. 2017;114:7623-7628 pubmed publisher
    ..we find that mutp53 augments insulin-induced AKT1 activation by binding and inhibiting the tumor suppressor DAB2IP (DAB2-interacting protein) in the cytoplasm...
  48. Chen Y, Lien H, Kao M, Lo U, Lin L, Lin C, et al. Sensitization of Radioresistant Prostate Cancer Cells by Resveratrol Isolated from Arachis hypogaea Stems. PLoS ONE. 2017;12:e0169204 pubmed publisher
    ..stem extract (PSE) for the first time and showed that both RV and PSE dose-dependently induced cell death in DOC-2/DAB2 interactive protein (DAB2IP)-deficient PCa cells with the radioresistant phenotype...
  49. Tao W, Moore R, Meng Y, Smith E, Xu X. Endocytic adaptors Arh and Dab2 control homeostasis of circulatory cholesterol. J Lipid Res. 2016;57:809-17 pubmed publisher
    ..In our genetic analysis of mutant mice, we found that deletion of another LDLR endocytic adaptor, Disabled-2 (Dab2), only slightly affected serum cholesterol levels...
  50. Xu S, Zhu J, Wu Z. Loss of Dab2 expression in breast cancer cells impairs their ability to deplete TGF-? and induce Tregs development via TGF-?. PLoS ONE. 2014;9:e91709 pubmed publisher
    b>Dab2 is a multifunctional adapter protein which is frequently under-expressed in a variety of cancers...
  51. Diwakar R, Pearson A, Colville Nash P, Baines D, Dockrell M. Role played by disabled-2 in albumin induced MAP Kinase signalling. Biochem Biophys Res Commun. 2008;366:675-80 pubmed
    ..However, the mechanisms by which megalin signals are unclear. The adaptor phosphoprotein Disabled-2 (Dab2) is known to interact with the cytoplasmic tail of megalin and may be involved in albumin-mediated MAPK signalling...
  52. Kuraoka M, Amatya V, Kushitani K, Mawas A, Miyata Y, Okada M, et al. Identification of DAB2 and Intelectin-1 as Novel Positive Immunohistochemical Markers of Epithelioid Mesothelioma by Transcriptome Microarray Analysis for Its Differentiation From Pulmonary Adenocarcinoma. Am J Surg Pathol. 2017;41:1045-1052 pubmed publisher
    ..Gene expression analysis revealed that disabled homolog 2 (DAB2) and Intelectin-1 had significantly higher expression in epithelioid mesothelioma compared with that ..
  53. Xie S, Xie Y, Zhang Y, Huang Q. [Effects of miR-145 on the migration and invasion of prostate cancer PC3 cells by targeting DAB2]. Yi Chuan. 2014;36:50-7 pubmed
    ..In this study, using bioinformatics analysis and in vitro assays, we identified DAB2 (Disabled homolog 2) as a downstream target gene of miR-145 during tumor metastasis process...
  54. Wu C, Miao X, Huang L, Che X, Jiang G, Yu D, et al. Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Nat Genet. 2011;44:62-6 pubmed publisher
    ..1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer. ..
  55. Cheong S, Choi H, Hong B, Gho Y, Han J. Dab2 is pivotal for endothelial cell migration by mediating VEGF expression in cancer cells. Exp Cell Res. 2012;318:550-7 pubmed publisher
    ..Here, we explore the role of Dab2 in tumor angiogenesis...
  56. Zheng L, Chen K, Zhu L, Su D, Cheng G. Low expression of DAB2IP predicts an unfavorable prognosis in human bladder carcinoma. Onco Targets Ther. 2017;10:5719-5726 pubmed publisher
    The DOC-2/DAB2 interactive protein (DAB2IP) is a novel member of the Ras GTPase-activating protein family, and its downregulation is an unfavorable prognostic factor in several human malignancies...
  57. Higashio H, Nishimura N, Ishizaki H, Miyoshi J, Orita S, Sakane A, et al. Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells. J Immunol. 2008;180:4774-84 pubmed
    The Doc2 family comprises the brain-specific Doc2alpha and the ubiquitous Doc2beta and Doc2gamma...
  58. Hung W, Huang C, Fan J, Huang D, Yeh C, Cheng J, et al. The endocytic adaptor protein Disabled-2 is required for cellular uptake of fibrinogen. Biochim Biophys Acta. 2012;1823:1778-88 pubmed publisher
    ..In this study, we investigated whether the endocytic adaptor protein Disabled-2 (DAB2) mediates fibrinogen uptake in an adaptor-specific manner...
  59. Kim J, Kang H, Larrivee B, Lee M, Mettlen M, Schmid S, et al. Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2. Dev Cell. 2012;23:441-8 pubmed publisher
    ..Here, we report that Disabled homolog 2 (Dab2), a cargo-specific adaptor protein for Clathrin, is essential to mediate the proangiogenic function of ..
  60. Cremazy A, Wood C, Smith D, Ferreira M, Johannsson O, Giacomin M, et al. Investigating copper toxicity in the tropical fish cardinal tetra (Paracheirodon axelrodi) in natural Amazonian waters: Measurements, modeling, and reality. Aquat Toxicol. 2016;180:353-363 pubmed publisher
    ..The implication of this observation is that, for metals risk assessment in tropical waters, similar to the Rio Negro, care must be used in applying BLM models developed using temperate DOC and temperate species. ..
  61. Inoue A, Sato O, Homma K, Ikebe M. DOC-2/DAB2 is the binding partner of myosin VI. Biochem Biophys Res Commun. 2002;292:300-7 pubmed
    ..Here we found that DOC-2/DAB2, a signaling molecule inhibiting the Ras cascade, binds to myosin VI at the globular tail domain...
  62. Ternes S, Rowling M. Vitamin D transport proteins megalin and disabled-2 are expressed in prostate and colon epithelial cells and are induced and activated by all-trans-retinoic acid. Nutr Cancer. 2013;65:900-7 pubmed publisher
    Megalin and disabled-2 (Dab2) are essential for uptake of the 25-hydroxycholecalciferol (25D3)-vitamin D binding protein (DBP) complex in tissues...
  63. Xie X, Zhang Z, Yang L, Yang D, Tang N, Zhao H, et al. Aberrant hypermethylation and reduced expression of disabled-2 promote the development of lung cancers. Int J Oncol. 2013;43:1636-42 pubmed publisher
    Disabled-2 (Dab2) is considered a tumor suppressor and is downregulated in cancers. We examined the promoter methylation status and expression levels of Dab2, and investigated their roles in the development of lung cancers...
  64. Adamson S, Griffiths R, Moravec R, Senthivinayagam S, Montgomery G, Chen W, et al. Disabled homolog 2 controls macrophage phenotypic polarization and adipose tissue inflammation. J Clin Invest. 2016;126:1311-22 pubmed publisher
    ..Here, we have identified the adaptor protein disabled homolog 2 (DAB2) as a regulator of phenotypic switching in macrophages...
  65. Fu L, Rab A, Tang L, Bebok Z, Rowe S, Bartoszewski R, et al. ΔF508 CFTR surface stability is regulated by DAB2 and CHIP-mediated ubiquitination in post-endocytic compartments. PLoS ONE. 2015;10:e0123131 pubmed publisher
    ..To understand the mechanism of this rapid turnover, we examined the role of two adaptor complexes (AP-2 and Dab2) and three E3 ubiquitin ligases (c-Cbl, CHIP, and Nedd4-2) on low-temperature rescued ΔF508 CFTR endocytosis and ..
  66. Li C, Chen J, Chen T, Xu Z, Xu C, Ding C, et al. Aberrant Hypermethylation at Sites -86 to 226 of DAB2 Gene in Non-Small Cell Lung Cancer. Am J Med Sci. 2015;349:425-31 pubmed publisher
    ..Human Disabled-2 (DAB2) was reported to act as a tumor suppressor gene and was found downregulated in numerous cancer types...
  67. Xiao S, Charonko J, Fu X, Salmanzadeh A, Davalos R, Vlachos P, et al. Structure, sulfatide binding properties, and inhibition of platelet aggregation by a disabled-2 protein-derived peptide. J Biol Chem. 2012;287:37691-702 pubmed publisher
    Disabled-2 (Dab2) targets membranes and triggers a wide range of biological events, including endocytosis and platelet aggregation...
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