DAAM1

Summary

Gene Symbol: DAAM1
Description: dishevelled associated activator of morphogenesis 1
Alias: disheveled-associated activator of morphogenesis 1
Species: human
Products:     DAAM1

Top Publications

  1. Habas R, Kato Y, He X. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. Cell. 2001;107:843-54 pubmed
    ..Wnt/Fz activation of Rho requires the cytoplasmic protein Dishevelled (Dvl) and a novel Formin homology protein Daam1. Daam1 binds to both Dvl and Rho, and mediates Wnt-induced Dvl-Rho complex formation...
  2. Lu J, Meng W, Poy F, Maiti S, Goode B, Eck M. Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly. J Mol Biol. 2007;369:1258-69 pubmed
    b>Daam1 (dishevelled-associated activator of morphogenesis-1) is a diaphanous-related formin first studied as a novel dishevelled binding protein and shown to be crucial for the planar cell polarity (PCP) pathway in Xenopus...
  3. Aspenstrom P, Richnau N, Johansson A. The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics. Exp Cell Res. 2006;312:2180-94 pubmed
    ..One of the CIP4-binding proteins, DAAM1, was characterised in more detail...
  4. Bao B, Zhang L, Hu H, Yin S, Liang Z. Deletion of a single-copy DAAM1 gene in congenital heart defect: a case report. BMC Med Genet. 2012;13:63 pubmed publisher
    ..1 in a female fetus with complex congenital heart defects. This is the first description of DAAM1 gene deletion associated with congenital heart anomalies...
  5. Ju R, Cirone P, Lin S, Griesbach H, Slusarski D, Crews C. Activation of the planar cell polarity formin DAAM1 leads to inhibition of endothelial cell proliferation, migration, and angiogenesis. Proc Natl Acad Sci U S A. 2010;107:6906-11 pubmed publisher
    ..expression of a constitutively active C-terminal domain of Dishevelled-associated activator of morphogenesis 1 (DAAM1) selectively inhibited endothelial cell proliferation...
  6. Yamashita M, Higashi T, Suetsugu S, Sato Y, Ikeda T, Shirakawa R, et al. Crystal structure of human DAAM1 formin homology 2 domain. Genes Cells. 2007;12:1255-65 pubmed
    ..Here, we present the crystal structure of human DAAM1 FH2 dimer at 2.8 A resolution. This is the first dimeric structure of the mammalian formin...
  7. Liu W, Sato A, Khadka D, Bharti R, Diaz H, Runnels L, et al. Mechanism of activation of the Formin protein Daam1. Proc Natl Acad Sci U S A. 2008;105:210-5 pubmed
    ..Here we report that Daam1 is not significantly activated by Rho binding but rather by its interaction with Dishevelled (Dvl)...
  8. Sato A, Khadka D, Liu W, Bharti R, Runnels L, Dawid I, et al. Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation. Development. 2006;133:4219-31 pubmed
    ..We had previously identified the Formin homology protein Daam1 as an important link between Dishevelled and the Rho GTPase for cytoskeletal modulation...
  9. Higashi T, Ikeda T, Shirakawa R, Kondo H, Kawato M, Horiguchi M, et al. Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets. J Biol Chem. 2008;283:8746-55 pubmed publisher
    ..Here, we isolated two diaphanous-related formins, mDia1 and Daam1, in platelet extracts by GTP-RhoA affinity column chromatography...

More Information

Publications45

  1. Tsuji T, Ohta Y, Kanno Y, Hirose K, Ohashi K, Mizuno K. Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells. Mol Biol Cell. 2010;21:3590-600 pubmed publisher
    ..Dishevelled (Dvl) and its binding protein Daam1 mediate RhoA activation in this pathway...
  2. Balla B, Sárvári M, Kósa J, Kocsis Deák B, Tóbiás B, Arvai K, et al. Long-term selective estrogen receptor-beta agonist treatment modulates gene expression in bone and bone marrow of ovariectomized rats. J Steroid Biochem Mol Biol. 2019;188:185-194 pubmed publisher
    ..It is noteworthy that DPN restored mRNA expression of 10 OVX-induced changes (Aldh2, Col1a1, Daam1, Fgf12, Igf1, Il6r, Nfkb1, Notch1, Notch2 and Psen1) suggesting a modulatory role of ERβ in bone physiology...
  3. Ossipova O, Kerney R, Saint Jeannet J, Sokol S. Regulation of neural crest development by the formin family protein Daam1. Genesis. 2018;56:e23108 pubmed publisher
    ..b>Daam1 is a formin family protein that is present in embryonic ectoderm at the time of NC formation and can mediate ..
  4. Saengsawang W, Taylor K, Lumbard D, Mitok K, Price A, Pietila L, et al. CIP4 coordinates with phospholipids and actin-associated proteins to localize to the protruding edge and produce actin ribs and veils. J Cell Sci. 2013;126:2411-23 pubmed publisher
    ..We also demonstrate that CIP4 dynamically colocalizes with Ena/VASP and DAAM1, two proteins known to induce unbranched actin filament arrays and play important roles in neuronal development...
  5. Williams S, Weiner Z, Gilmore R. Human neuroglial cells internalize Borrelia burgdorferi by coiling phagocytosis mediated by Daam1. PLoS ONE. 2018;13:e0197413 pubmed publisher
    ..burgdorferi via coiling phagocytosis mediated by the formin, Daam1, a process similarly described for human macrophages. Following coincubation with glial cells, B...
  6. Batissoco A, Salazar Silva R, Oiticica J, Bento R, Mingroni Netto R, Haddad L. A Cell Junctional Protein Network Associated with Connexin-26. Int J Mol Sci. 2018;19: pubmed publisher
    ..by affinity capture and identified 12 unique proteins associated with cell junctions or cytoskeleton (CGN, DAAM1, FLNB, GAPDH, HOMER2, MAP7, MAPRE2 (EB2), JUP, PTK2B, RAI14, TJP1, and VCL) by using mass spectrometry...
  7. Wagh D, Terry Lorenzo R, Waites C, Leal Ortiz S, Maas C, Reimer R, et al. Piccolo Directs Activity Dependent F-Actin Assembly from Presynaptic Active Zones via Daam1. PLoS ONE. 2015;10:e0120093 pubmed publisher
    ..Here we have identified Daam1, a Formin that functions with Profilin to drive F-actin assembly, as a novel Piccolo binding partner...
  8. Yan T, Zhang A, Shi F, Chang F, Mei J, Liu Y, et al. Integrin αvβ3-associated DAAM1 is essential for collagen-induced invadopodia extension and cell haptotaxis in breast cancer cells. J Biol Chem. 2018;293:10172-10185 pubmed publisher
    The formin protein dishevelled-associated activator of morphogenesis 1 (DAAM1) polymerizes straight actin filaments and mediates migration of cancer cells...
  9. Pariante P, Dotolo R, Venditti M, Ferrara D, Donizetti A, Aniello F, et al. First Evidence of DAAM1 Localization During the Post-Natal Development of Rat Testis and in Mammalian Sperm. J Cell Physiol. 2016;231:2172-84 pubmed publisher
    Dishevelled-associated activator of morphogenesis 1 (DAAM1) is a formin-family protein involved in nucleation of unbranched actin filaments and in cytoskeletal organization through Wnt-Dishevelled PCP pathway, which participates in ..
  10. Sellers K, Elliott C, Jackson J, Ghosh A, Ribe E, Rojo A, et al. Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil. Alzheimers Dement. 2018;14:306-317 pubmed publisher
    ..is also Dkk1 and Wnt-PCP dependent, mediated by the arm of Wnt-PCP regulating actin cytoskeletal dynamics via Daam1, RhoA and ROCK, and can be blocked by the drug fasudil...
  11. Kawabata Galbraith K, Fujishima K, Mizuno H, Lee S, Uemura T, Sakimura K, et al. MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells. Cell Rep. 2018;24:95-106.e9 pubmed publisher
    ..concomitant with elongated dendritic filopodia and was phenocopied by overactivation of the actin nucleator formin DAAM1 localized in the tips of PC dendritic protrusions...
  12. López Escobar B, Cano D, Rojas A, De Felipe B, Palma F, Sánchez Alcázar J, et al. The effect of maternal diabetes on the Wnt-PCP pathway during embryogenesis as reflected in the developing mouse eye. Dis Model Mech. 2015;8:157-68 pubmed publisher
    ..of elements in the non-canonical Wnt-PCP pathway, such as the Dishevelled-associated activator of morphogenesis 1 (Daam1) and Vangl2...
  13. Nishimura T, Ito S, Saito H, Hiver S, Shigetomi K, Ikenouchi J, et al. DAAM1 stabilizes epithelial junctions by restraining WAVE complex-dependent lateral membrane motility. J Cell Biol. 2016;215:559-573 pubmed
    ..We found that DAAM1, a formin family actin regulator, accumulated at the LCs, and its depletion caused dispersion of actin filaments ..
  14. Venditti M, Fasano C, Santillo A, Aniello F, Minucci S. First evidence of DAAM1 localization in mouse seminal vesicles and its possible involvement during regulated exocytosis. C R Biol. 2018;341:228-234 pubmed publisher
    Dishevelled-associated activator of morphogenesis 1 (DAAM1) is a protein belonging to the formin family, which regulates, together with the small GTPase RhoA, the nucleation and the assembly of actin fibres through Wnt-Dishevelled PCP ..
  15. Lu Y, Zhang Y, Pan M, Kim N, Sun S, Cui X. Daam1 regulates fascin for actin assembly in mouse oocyte meiosis. Cell Cycle. 2017;16:1350-1356 pubmed publisher
    As a formin protein, Daam1 (Dishevelled-associated activator of morphogenesis 1) is reported to regulate series of cell processes like endocytosis, cell morphology and migration via its effects on actin assembly in mitosis...
  16. Chemek M, Venditti M, Boughamoura S, Mimouna S, Messaoudi I, Minucci S. Involvement of testicular DAAM1 expression in zinc protection against cadmium-induced male rat reproductive toxicity. J Cell Physiol. 2018;233:630-640 pubmed publisher
    In order to verify the effects of exposure to Cd and Zn on testicular DAAM1 gene and protein expression and also to ascertain their involvement in the protective role of Zn in prevent the testicular toxicity Cd-induced in male offspring ..
  17. Rydell Törmänen K, Zhou X, Hallgren O, Einarsson J, Eriksson L, Andersson Sjöland A, et al. Aberrant nonfibrotic parenchyma in idiopathic pulmonary fibrosis is correlated with decreased ?-catenin inhibition and increased Wnt5a/b interaction. Physiol Rep. 2016;4: pubmed publisher
    ..We investigated markers of Wnt signaling (?-catenin, Wnt3a, ICAT, Wnt5a/b, DAAM1 and NLK) histologically in lung parenchyma with variable degree of fibrosis...
  18. Zhang W, Bojorquez Gomez A, Velez D, Xu G, Sanchez K, Shen J, et al. A global transcriptional network connecting noncoding mutations to changes in tumor gene expression. Nat Genet. 2018;50:613-620 pubmed publisher
    ..Among these, we find that the effects of noncoding mutations on DAAM1, MTG2 and HYI transcription are recapitulated in multiple cancer cell lines and that increasing DAAM1 expression ..
  19. Ajima R, Bisson J, Helt J, Nakaya M, Habas R, Tessarollo L, et al. DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly. Dev Biol. 2015;408:126-39 pubmed publisher
    Wnt ligands regulate heart morphogenesis but the underlying mechanisms remain unclear. Two Formin-related proteins, DAAM1 and 2, were previously found to bind the Wnt effector Disheveled...
  20. Patil P, Kibiryeva N, Uechi T, Marshall J, O Brien J, Artman M, et al. scaRNAs regulate splicing and vertebrate heart development. Biochim Biophys Acta. 2015;1852:1619-29 pubmed publisher
    ..g., GATA4, NOTCH2, DAAM1, DICER1, MBNL1 and MBNL2)...
  21. Ossipova O, Chuykin I, Chu C, Sokol S. Vangl2 cooperates with Rab11 and Myosin V to regulate apical constriction during vertebrate gastrulation. Development. 2015;142:99-107 pubmed publisher
    ..Further experiments show that Vangl2, as well as Daam1 and Rho-associated kinase (Rock), regulate apical constriction of bottle cells at the blastopore and ectopic ..
  22. Xiong H, Yan T, Zhang W, Shi F, Jiang X, Wang X, et al. miR-613 inhibits cell migration and invasion by downregulating Daam1 in triple-negative breast cancer. Cell Signal. 2018;44:33-42 pubmed publisher
    Dishevelled-associated activator of morphogenesis 1 (Daam1) is a formin protein and participates in regulating cell migration of triple-negative breast cancer (TNBC) cells...
  23. Yasunaga T, Hoff S, Schell C, Helmstädter M, Kretz O, Kuechlin S, et al. The polarity protein Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells. J Cell Biol. 2015;211:963-73 pubmed publisher
    ..interact with each other and that Inturned mediates the formation of ternary protein complexes between NPHP4 and DAAM1. Knockdown of daam1, but not formin-2, resulted in similar disruption of the subapical actin web, whereas nphp4 ..
  24. Suzuki J, Roy B, Ogaeri T, Kakinuma N, Kiyama R. Depletion of tumor suppressor Kank1 induces centrosomal amplification via hyperactivation of RhoA. Exp Cell Res. 2017;353:79-87 pubmed publisher
    ..Kank1 interacts with Daam1, known to bind to and activate a small GTPase, RhoA, in actin assembly...
  25. Zhu Y, Tian Y, Du J, Hu Z, Yang L, Liu J, et al. Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration. PLoS ONE. 2012;7:e37823 pubmed publisher
    The Dishevelled (Dvl) and Dishevelled-associated activator of morphogenesis 1 (Daam1) pathway triggered by Wnt5a regulates cellular polarity during development and tissue homoeostasis...
  26. Guillabert Gourgues A, Jaspard Vinassa B, Bats M, Sewduth R, Franzl N, Peghaire C, et al. Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity-signaling pathway. Mol Biol Cell. 2016;27:941-53 pubmed publisher
    ..PCP) pathway, through the recruitment of Dishevelled (Dvl) and Dvl-associated activator of morphogenesis (Daam1), has been proposed to regulate cell actin cytoskeleton and microtubule (MT) reorganization for oriented cell ..
  27. Higashi T, Ikeda T, Murakami T, Shirakawa R, Kawato M, Okawa K, et al. Flightless-I (Fli-I) regulates the actin assembly activity of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperation with active Rho GTPase. J Biol Chem. 2010;285:16231-8 pubmed publisher
    ..Diaphanous-related formins (DRFs), such as Daam1 and mDia1, play central roles in actin dynamics through assembling linear actin filaments...
  28. Tanaka K. Formin family proteins in cytoskeletal control. Biochem Biophys Res Commun. 2000;267:479-81 pubmed
    ..Recent evidence indicates that the formin family proteins play a crucial role in the reorganization of the cytoskeleton. In this review, recent advance in the understanding of the functions of formin family proteins is discussed. ..
  29. Babayeva S, Zilber Y, Torban E. Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes. Am J Physiol Renal Physiol. 2011;300:F549-60 pubmed publisher
    ..The pathway is functional since Wnt5a causes redistribution of PCP proteins Dishevelled and Daam1. We also show that Wnt5a treatment changes podocyte morphology, alters nephrin distribution, increases the number ..
  30. Xu X, Gnatenko D, Ju J, Hitchcock I, Martin D, Zhu W, et al. Systematic analysis of microRNA fingerprints in thrombocythemic platelets using integrated platforms. Blood. 2012;120:3575-85 pubmed publisher
    ..datasets with functional reporter assays identified dishevelled associated activator of morphogenesis 1 (DAAM1) as a miR 490 5p protein target demonstrating decreased expression in ET platelets, putatively by translational ..
  31. Luo W, Lieu Z, Manser E, Bershadsky A, Sheetz M. Formin DAAM1 Organizes Actin Filaments in the Cytoplasmic Nodal Actin Network. PLoS ONE. 2016;11:e0163915 pubmed publisher
    ..We previously described such a network that forms upon Latrunculin A (LatA) treatment, in which formin DAAM1 was localized at these nodes. Knock down of DAAM1 reduced the mobility of actin nodes but the nodes remained...
  32. Hoffmann A, Naj X, Linder S. Daam1 is a regulator of filopodia formation and phagocytic uptake of Borrelia burgdorferi by primary human macrophages. FASEB J. 2014;28:3075-89 pubmed publisher
    ..In this study, we showed that the actin-regulatory formin Daam1 is important in Borrelia phagocytosis by primary human macrophages...
  33. Liu G, Yan T, Li X, Sun J, Zhang B, Wang H, et al. Daam1 activates RhoA to regulate Wnt5a?induced glioblastoma cell invasion. Oncol Rep. 2017;: pubmed publisher
    The signaling pathway of dishevelled-associated activator of morphogenesis 1 (Daam1) triggered by Wnt5a drives cell movement and migration during breast cancer metastasis...
  34. Yanai S, Wakayama M, Nakayama H, Shinozaki M, Tsukuma H, Tochigi N, et al. Implication of overexpression of dishevelled-associated activator of morphogenesis 1 (Daam-1) for the pathogenesis of human Idiopathic Pulmonary Arterial Hypertension (IPAH). Diagn Pathol. 2017;12:25 pubmed publisher
    ..High Daam-1 expression may upregulate the Wnt/PCP pathway and cause IPAH. ..
  35. Ang S, Zhao Z, Lim L, Manser E. DAAM1 is a formin required for centrosome re-orientation during cell migration. PLoS ONE. 2010;5: pubmed publisher
    Disheveled-associated activator of morphogenesis 1 (DAAM1) is a formin acting downstream of Wnt signaling that is important for planar cell polarity...
  36. Seo H, Habas R, Chang C, Wang J. Bimodal regulation of Dishevelled function by Vangl2 during morphogenesis. Hum Mol Genet. 2017;26:2053-2061 pubmed publisher
    ..At the same time, Vangl2 inhibits Dvl from interacting with its downstream effector Daam1 (Dishevelled associated activator of morphogenesis 1), and functionally suppresses Dvl ? Daam1 cascade during CE...