DAAM1

Summary

Gene Symbol: DAAM1
Description: dishevelled associated activator of morphogenesis 1
Alias: disheveled-associated activator of morphogenesis 1
Species: human
Products:     DAAM1

Top Publications

  1. Habas R, Kato Y, He X. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. Cell. 2001;107:843-54 pubmed
    ..Wnt/Fz activation of Rho requires the cytoplasmic protein Dishevelled (Dvl) and a novel Formin homology protein Daam1. Daam1 binds to both Dvl and Rho, and mediates Wnt-induced Dvl-Rho complex formation...
  2. Lu J, Meng W, Poy F, Maiti S, Goode B, Eck M. Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly. J Mol Biol. 2007;369:1258-69 pubmed
    b>Daam1 (dishevelled-associated activator of morphogenesis-1) is a diaphanous-related formin first studied as a novel dishevelled binding protein and shown to be crucial for the planar cell polarity (PCP) pathway in Xenopus...
  3. Aspenstrom P, Richnau N, Johansson A. The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics. Exp Cell Res. 2006;312:2180-94 pubmed
    ..One of the CIP4-binding proteins, DAAM1, was characterised in more detail...
  4. Ju R, Cirone P, Lin S, Griesbach H, Slusarski D, Crews C. Activation of the planar cell polarity formin DAAM1 leads to inhibition of endothelial cell proliferation, migration, and angiogenesis. Proc Natl Acad Sci U S A. 2010;107:6906-11 pubmed publisher
    ..expression of a constitutively active C-terminal domain of Dishevelled-associated activator of morphogenesis 1 (DAAM1) selectively inhibited endothelial cell proliferation...
  5. Bao B, Zhang L, Hu H, Yin S, Liang Z. Deletion of a single-copy DAAM1 gene in congenital heart defect: a case report. BMC Med Genet. 2012;13:63 pubmed publisher
    ..1 in a female fetus with complex congenital heart defects. This is the first description of DAAM1 gene deletion associated with congenital heart anomalies...
  6. Yamashita M, Higashi T, Suetsugu S, Sato Y, Ikeda T, Shirakawa R, et al. Crystal structure of human DAAM1 formin homology 2 domain. Genes Cells. 2007;12:1255-65 pubmed
    ..Here, we present the crystal structure of human DAAM1 FH2 dimer at 2.8 A resolution. This is the first dimeric structure of the mammalian formin...
  7. Liu W, Sato A, Khadka D, Bharti R, Diaz H, Runnels L, et al. Mechanism of activation of the Formin protein Daam1. Proc Natl Acad Sci U S A. 2008;105:210-5 pubmed
    ..Here we report that Daam1 is not significantly activated by Rho binding but rather by its interaction with Dishevelled (Dvl)...
  8. Sato A, Khadka D, Liu W, Bharti R, Runnels L, Dawid I, et al. Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation. Development. 2006;133:4219-31 pubmed
    ..We had previously identified the Formin homology protein Daam1 as an important link between Dishevelled and the Rho GTPase for cytoskeletal modulation...
  9. Higashi T, Ikeda T, Shirakawa R, Kondo H, Kawato M, Horiguchi M, et al. Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets. J Biol Chem. 2008;283:8746-55 pubmed publisher
    ..Here, we isolated two diaphanous-related formins, mDia1 and Daam1, in platelet extracts by GTP-RhoA affinity column chromatography...
  10. Suzuki J, Roy B, Ogaeri T, Kakinuma N, Kiyama R. Depletion of tumor suppressor Kank1 induces centrosomal amplification via hyperactivation of RhoA. Exp Cell Res. 2017;353:79-87 pubmed publisher
    ..Kank1 interacts with Daam1, known to bind to and activate a small GTPase, RhoA, in actin assembly...

Detail Information

Publications23

  1. Habas R, Kato Y, He X. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. Cell. 2001;107:843-54 pubmed
    ..Wnt/Fz activation of Rho requires the cytoplasmic protein Dishevelled (Dvl) and a novel Formin homology protein Daam1. Daam1 binds to both Dvl and Rho, and mediates Wnt-induced Dvl-Rho complex formation...
  2. Lu J, Meng W, Poy F, Maiti S, Goode B, Eck M. Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly. J Mol Biol. 2007;369:1258-69 pubmed
    b>Daam1 (dishevelled-associated activator of morphogenesis-1) is a diaphanous-related formin first studied as a novel dishevelled binding protein and shown to be crucial for the planar cell polarity (PCP) pathway in Xenopus...
  3. Aspenstrom P, Richnau N, Johansson A. The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics. Exp Cell Res. 2006;312:2180-94 pubmed
    ..One of the CIP4-binding proteins, DAAM1, was characterised in more detail...
  4. Ju R, Cirone P, Lin S, Griesbach H, Slusarski D, Crews C. Activation of the planar cell polarity formin DAAM1 leads to inhibition of endothelial cell proliferation, migration, and angiogenesis. Proc Natl Acad Sci U S A. 2010;107:6906-11 pubmed publisher
    ..expression of a constitutively active C-terminal domain of Dishevelled-associated activator of morphogenesis 1 (DAAM1) selectively inhibited endothelial cell proliferation...
  5. Bao B, Zhang L, Hu H, Yin S, Liang Z. Deletion of a single-copy DAAM1 gene in congenital heart defect: a case report. BMC Med Genet. 2012;13:63 pubmed publisher
    ..1 in a female fetus with complex congenital heart defects. This is the first description of DAAM1 gene deletion associated with congenital heart anomalies...
  6. Yamashita M, Higashi T, Suetsugu S, Sato Y, Ikeda T, Shirakawa R, et al. Crystal structure of human DAAM1 formin homology 2 domain. Genes Cells. 2007;12:1255-65 pubmed
    ..Here, we present the crystal structure of human DAAM1 FH2 dimer at 2.8 A resolution. This is the first dimeric structure of the mammalian formin...
  7. Liu W, Sato A, Khadka D, Bharti R, Diaz H, Runnels L, et al. Mechanism of activation of the Formin protein Daam1. Proc Natl Acad Sci U S A. 2008;105:210-5 pubmed
    ..Here we report that Daam1 is not significantly activated by Rho binding but rather by its interaction with Dishevelled (Dvl)...
  8. Sato A, Khadka D, Liu W, Bharti R, Runnels L, Dawid I, et al. Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation. Development. 2006;133:4219-31 pubmed
    ..We had previously identified the Formin homology protein Daam1 as an important link between Dishevelled and the Rho GTPase for cytoskeletal modulation...
  9. Higashi T, Ikeda T, Shirakawa R, Kondo H, Kawato M, Horiguchi M, et al. Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets. J Biol Chem. 2008;283:8746-55 pubmed publisher
    ..Here, we isolated two diaphanous-related formins, mDia1 and Daam1, in platelet extracts by GTP-RhoA affinity column chromatography...
  10. Suzuki J, Roy B, Ogaeri T, Kakinuma N, Kiyama R. Depletion of tumor suppressor Kank1 induces centrosomal amplification via hyperactivation of RhoA. Exp Cell Res. 2017;353:79-87 pubmed publisher
    ..Kank1 interacts with Daam1, known to bind to and activate a small GTPase, RhoA, in actin assembly...
  11. Yasunaga T, Hoff S, Schell C, Helmstädter M, Kretz O, Kuechlin S, et al. The polarity protein Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells. J Cell Biol. 2015;211:963-73 pubmed publisher
    ..interact with each other and that Inturned mediates the formation of ternary protein complexes between NPHP4 and DAAM1. Knockdown of daam1, but not formin-2, resulted in similar disruption of the subapical actin web, whereas nphp4 ..
  12. Zhu Y, Tian Y, Du J, Hu Z, Yang L, Liu J, et al. Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration. PLoS ONE. 2012;7:e37823 pubmed publisher
    The Dishevelled (Dvl) and Dishevelled-associated activator of morphogenesis 1 (Daam1) pathway triggered by Wnt5a regulates cellular polarity during development and tissue homoeostasis...
  13. Higashi T, Ikeda T, Murakami T, Shirakawa R, Kawato M, Okawa K, et al. Flightless-I (Fli-I) regulates the actin assembly activity of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperation with active Rho GTPase. J Biol Chem. 2010;285:16231-8 pubmed publisher
    ..Diaphanous-related formins (DRFs), such as Daam1 and mDia1, play central roles in actin dynamics through assembling linear actin filaments...
  14. Guillabert Gourgues A, Jaspard Vinassa B, Bats M, Sewduth R, Franzl N, Peghaire C, et al. Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity-signaling pathway. Mol Biol Cell. 2016;27:941-53 pubmed publisher
    ..PCP) pathway, through the recruitment of Dishevelled (Dvl) and Dvl-associated activator of morphogenesis (Daam1), has been proposed to regulate cell actin cytoskeleton and microtubule (MT) reorganization for oriented cell ..
  15. Tanaka K. Formin family proteins in cytoskeletal control. Biochem Biophys Res Commun. 2000;267:479-81 pubmed
    ..Recent evidence indicates that the formin family proteins play a crucial role in the reorganization of the cytoskeleton. In this review, recent advance in the understanding of the functions of formin family proteins is discussed. ..
  16. Babayeva S, Zilber Y, Torban E. Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes. Am J Physiol Renal Physiol. 2011;300:F549-60 pubmed publisher
    ..The pathway is functional since Wnt5a causes redistribution of PCP proteins Dishevelled and Daam1. We also show that Wnt5a treatment changes podocyte morphology, alters nephrin distribution, increases the number ..
  17. Xu X, Gnatenko D, Ju J, Hitchcock I, Martin D, Zhu W, et al. Systematic analysis of microRNA fingerprints in thrombocythemic platelets using integrated platforms. Blood. 2012;120:3575-85 pubmed publisher
    ..datasets with functional reporter assays identified dishevelled associated activator of morphogenesis 1 (DAAM1) as a miR 490 5p protein target demonstrating decreased expression in ET platelets, putatively by translational ..
  18. Hoffmann A, Naj X, Linder S. Daam1 is a regulator of filopodia formation and phagocytic uptake of Borrelia burgdorferi by primary human macrophages. FASEB J. 2014;28:3075-89 pubmed publisher
    ..In this study, we showed that the actin-regulatory formin Daam1 is important in Borrelia phagocytosis by primary human macrophages...
  19. Luo W, Lieu Z, Manser E, Bershadsky A, Sheetz M. Formin DAAM1 Organizes Actin Filaments in the Cytoplasmic Nodal Actin Network. PLoS ONE. 2016;11:e0163915 pubmed publisher
    ..We previously described such a network that forms upon Latrunculin A (LatA) treatment, in which formin DAAM1 was localized at these nodes. Knock down of DAAM1 reduced the mobility of actin nodes but the nodes remained...
  20. Liu G, Yan T, Li X, Sun J, Zhang B, Wang H, et al. Daam1 activates RhoA to regulate Wnt5a?induced glioblastoma cell invasion. Oncol Rep. 2017;: pubmed publisher
    The signaling pathway of dishevelled-associated activator of morphogenesis 1 (Daam1) triggered by Wnt5a drives cell movement and migration during breast cancer metastasis...
  21. Yanai S, Wakayama M, Nakayama H, Shinozaki M, Tsukuma H, Tochigi N, et al. Implication of overexpression of dishevelled-associated activator of morphogenesis 1 (Daam-1) for the pathogenesis of human Idiopathic Pulmonary Arterial Hypertension (IPAH). Diagn Pathol. 2017;12:25 pubmed publisher
    ..High Daam-1 expression may upregulate the Wnt/PCP pathway and cause IPAH. ..
  22. Ang S, Zhao Z, Lim L, Manser E. DAAM1 is a formin required for centrosome re-orientation during cell migration. PLoS ONE. 2010;5: pubmed publisher
    Disheveled-associated activator of morphogenesis 1 (DAAM1) is a formin acting downstream of Wnt signaling that is important for planar cell polarity...
  23. Seo H, Habas R, Chang C, Wang J. Bimodal regulation of Dishevelled function by Vangl2 during morphogenesis. Hum Mol Genet. 2017;26:2053-2061 pubmed publisher
    ..At the same time, Vangl2 inhibits Dvl from interacting with its downstream effector Daam1 (Dishevelled associated activator of morphogenesis 1), and functionally suppresses Dvl ? Daam1 cascade during CE...