cytoglobin

Summary

Gene Symbol: cytoglobin
Description: cytoglobin
Alias: HGB, STAP, cytoglobin, histoglobin, stellate cell activation-associated protein
Species: human
Products:     cytoglobin

Top Publications

  1. Kawada N, Kristensen D, Asahina K, Nakatani K, Minamiyama Y, Seki S, et al. Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells. J Biol Chem. 2001;276:25318-23 pubmed
    ..of the activation of rat stellate cell, a liver-specific pericyte, led to the discovery of a novel protein named STAP (stellate cell activation-associated protein). We cloned STAP cDNA...
  2. Hamdane D, Kiger L, Dewilde S, Green B, Pesce A, Uzan J, et al. The redox state of the cell regulates the ligand binding affinity of human neuroglobin and cytoglobin. J Biol Chem. 2003;278:51713-21 pubmed
    Neuroglobin and cytoglobin reversibly bind oxygen in competition with the distal histidine, and the observed oxygen affinity therefore depends on the properties of both ligands...
  3. Geuens E, Brouns I, Flamez D, Dewilde S, Timmermans J, Moens L. A globin in the nucleus!. J Biol Chem. 2003;278:30417-20 pubmed
    b>Cytoglobin and neuroglobin are recently discovered members of the globin family. In situ hybridization localized neuroglobin mainly in brain and retina, while cytoglobin was expressed ubiquitously in all analyzed tissues...
  4. Liu X, Tong J, Zweier J, Follmer D, Hemann C, Ismail R, et al. Differences in oxygen-dependent nitric oxide metabolism by cytoglobin and myoglobin account for their differing functional roles. FEBS J. 2013;280:3621-31 pubmed publisher
    ..However, the Mb concentration is very low in vascular smooth muscle, where low concentrations of cytoglobin (Cygb) may play a major role in metabolizing NO...
  5. Hodges N, Innocent N, Dhanda S, Graham M. Cellular protection from oxidative DNA damage by over-expression of the novel globin cytoglobin in vitro. Mutagenesis. 2008;23:293-8 pubmed publisher
    b>Cytoglobin is a recently identified member of the mammalian globin family that is expressed in neuronal cells in the central and peripheral nervous system where its physiological role remains to be determined...
  6. Gardner A, Cook M, Gardner P. Nitric-oxide dioxygenase function of human cytoglobin with cellular reductants and in rat hepatocytes. J Biol Chem. 2010;285:23850-7 pubmed publisher
    b>Cytoglobin (Cygb) was investigated for its capacity to function as a NO dioxygenase (NOD) in vitro and in hepatocytes. Ascorbate and cytochrome b(5) were found to support a high NOD activity...
  7. Liu X, Follmer D, Zweier J, Huang X, Hemann C, Liu K, et al. Characterization of the function of cytoglobin as an oxygen-dependent regulator of nitric oxide concentration. Biochemistry. 2012;51:5072-82 pubmed publisher
    ..While cytoglobin (Cygb) was discovered a decade ago, its physiological function remains uncertain...
  8. Shaw R, Liloglou T, Rogers S, Brown J, Vaughan E, Lowe D, et al. Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing. Br J Cancer. 2006;94:561-8 pubmed
    ..primers were designed to amplify 75-200 bp regions of the CpG rich gene promoters of p16, RARbeta, E-cadherin, cytoglobin and cyclinA1. Methylation status of 4-5 CpG sites per gene was determined by pyrosequencing...
  9. de Sanctis D, Dewilde S, Pesce A, Moens L, Ascenzi P, Hankeln T, et al. Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination. J Mol Biol. 2004;336:917-27 pubmed
    b>Cytoglobin is a recently discovered hemeprotein belonging to the globin superfamily together with hemoglobin, myoglobin and neuroglobin...
  10. Fago A, Hundahl C, Dewilde S, Gilany K, Moens L, Weber R. Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin. Molecular mechanisms and physiological significance. J Biol Chem. 2004;279:44417-26 pubmed
    Two new globin proteins have recently been discovered in vertebrates, neuroglobin in neurons and cytoglobin in all tissues, both showing heme hexacoordination by the distal His(E7) in the absence of gaseous ligands...

Detail Information

Publications93

  1. Kawada N, Kristensen D, Asahina K, Nakatani K, Minamiyama Y, Seki S, et al. Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells. J Biol Chem. 2001;276:25318-23 pubmed
    ..of the activation of rat stellate cell, a liver-specific pericyte, led to the discovery of a novel protein named STAP (stellate cell activation-associated protein). We cloned STAP cDNA...
  2. Hamdane D, Kiger L, Dewilde S, Green B, Pesce A, Uzan J, et al. The redox state of the cell regulates the ligand binding affinity of human neuroglobin and cytoglobin. J Biol Chem. 2003;278:51713-21 pubmed
    Neuroglobin and cytoglobin reversibly bind oxygen in competition with the distal histidine, and the observed oxygen affinity therefore depends on the properties of both ligands...
  3. Geuens E, Brouns I, Flamez D, Dewilde S, Timmermans J, Moens L. A globin in the nucleus!. J Biol Chem. 2003;278:30417-20 pubmed
    b>Cytoglobin and neuroglobin are recently discovered members of the globin family. In situ hybridization localized neuroglobin mainly in brain and retina, while cytoglobin was expressed ubiquitously in all analyzed tissues...
  4. Liu X, Tong J, Zweier J, Follmer D, Hemann C, Ismail R, et al. Differences in oxygen-dependent nitric oxide metabolism by cytoglobin and myoglobin account for their differing functional roles. FEBS J. 2013;280:3621-31 pubmed publisher
    ..However, the Mb concentration is very low in vascular smooth muscle, where low concentrations of cytoglobin (Cygb) may play a major role in metabolizing NO...
  5. Hodges N, Innocent N, Dhanda S, Graham M. Cellular protection from oxidative DNA damage by over-expression of the novel globin cytoglobin in vitro. Mutagenesis. 2008;23:293-8 pubmed publisher
    b>Cytoglobin is a recently identified member of the mammalian globin family that is expressed in neuronal cells in the central and peripheral nervous system where its physiological role remains to be determined...
  6. Gardner A, Cook M, Gardner P. Nitric-oxide dioxygenase function of human cytoglobin with cellular reductants and in rat hepatocytes. J Biol Chem. 2010;285:23850-7 pubmed publisher
    b>Cytoglobin (Cygb) was investigated for its capacity to function as a NO dioxygenase (NOD) in vitro and in hepatocytes. Ascorbate and cytochrome b(5) were found to support a high NOD activity...
  7. Liu X, Follmer D, Zweier J, Huang X, Hemann C, Liu K, et al. Characterization of the function of cytoglobin as an oxygen-dependent regulator of nitric oxide concentration. Biochemistry. 2012;51:5072-82 pubmed publisher
    ..While cytoglobin (Cygb) was discovered a decade ago, its physiological function remains uncertain...
  8. Shaw R, Liloglou T, Rogers S, Brown J, Vaughan E, Lowe D, et al. Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing. Br J Cancer. 2006;94:561-8 pubmed
    ..primers were designed to amplify 75-200 bp regions of the CpG rich gene promoters of p16, RARbeta, E-cadherin, cytoglobin and cyclinA1. Methylation status of 4-5 CpG sites per gene was determined by pyrosequencing...
  9. de Sanctis D, Dewilde S, Pesce A, Moens L, Ascenzi P, Hankeln T, et al. Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination. J Mol Biol. 2004;336:917-27 pubmed
    b>Cytoglobin is a recently discovered hemeprotein belonging to the globin superfamily together with hemoglobin, myoglobin and neuroglobin...
  10. Fago A, Hundahl C, Dewilde S, Gilany K, Moens L, Weber R. Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin. Molecular mechanisms and physiological significance. J Biol Chem. 2004;279:44417-26 pubmed
    Two new globin proteins have recently been discovered in vertebrates, neuroglobin in neurons and cytoglobin in all tissues, both showing heme hexacoordination by the distal His(E7) in the absence of gaseous ligands...
  11. Xinarianos G, McRonald F, Risk J, Bowers N, Nikolaidis G, Field J, et al. Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer. Hum Mol Genet. 2006;15:2038-44 pubmed
    ..One candidate tumour-suppressor gene is cytoglobin (CYGB), which is contained entirely within the 42.5 kb tylosis with oesophageal cancer (TOC) minimal region...
  12. Makino M, Sugimoto H, Sawai H, Kawada N, Yoshizato K, Shiro Y. High-resolution structure of human cytoglobin: identification of extra N- and C-termini and a new dimerization mode. Acta Crystallogr D Biol Crystallogr. 2006;62:671-7 pubmed
    b>Cytoglobin (Cgb) is a recently discovered member of the vertebrate haem-containing globin family. The structure of a new crystal form of wild-type human Cgb (space group C2) was determined at a resolution of 1.68 Angstrom...
  13. Shivapurkar N, Stastny V, Okumura N, Girard L, Xie Y, Prinsen C, et al. Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene. Cancer Res. 2008;68:7448-56 pubmed publisher
    b>Cytoglobin (CYGB) is a recently discovered vertebrate globin distantly related to myoglobin with unknown function. CYGB is assigned to chromosomal region 17q25, which is frequently lost in multiple malignancies...
  14. Shaw R, Omar M, Rokadiya S, Kogera F, Lowe D, Hall G, et al. Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer. Br J Cancer. 2009;101:139-44 pubmed publisher
    b>Cytoglobin (Cygb) was first described in 2002 as an intracellular globin of unknown function. We have previously shown the downregulation of cytoglobin as a key event in a familial cancer syndrome of the upper aerodigestive tract...
  15. Halligan K, Jourd heuil F, JOURD HEUIL D. Cytoglobin is expressed in the vasculature and regulates cell respiration and proliferation via nitric oxide dioxygenation. J Biol Chem. 2009;284:8539-47 pubmed publisher
    ..In the present study, we tested the hypothesis that cytoglobin, a newly discovered hexacoordinated globin, participates in cell-mediated NO consumption...
  16. Reeder B, Svistunenko D, Wilson M. Lipid binding to cytoglobin leads to a change in haem co-ordination: a role for cytoglobin in lipid signalling of oxidative stress. Biochem J. 2011;434:483-92 pubmed publisher
    b>Cytoglobin is a recently discovered hexa-co-ordinate haemoglobin that does not appear to function as a classical oxygen-binding protein...
  17. Schmidt M, Gerlach F, Avivi A, Laufs T, Wystub S, Simpson J, et al. Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia. J Biol Chem. 2004;279:8063-9 pubmed
    b>Cytoglobin is a recently discovered vertebrate globin distantly related to myoglobin, and its function is unknown. Here we present the first detailed analysis of the distribution and expression of cytoglobin...
  18. Guo X, Philipsen S, Tan Un K. Study of the hypoxia-dependent regulation of human CYGB gene. Biochem Biophys Res Commun. 2007;364:145-50 pubmed
    b>Cytoglobin (CYGB) is ubiquitously expressed in all tissues and has been characterized as a respiratory protein in connective tissues...
  19. Fang J, Ma I, Allalunis Turner J. Knockdown of cytoglobin expression sensitizes human glioma cells to radiation and oxidative stress. Radiat Res. 2011;176:198-207 pubmed
    b>Cytoglobin is a recently identified vertebrate globin whose functions include scavenging reactive oxygen and nitrosative species. In tumor cells, CYGB may function as a tumor suppressor gene...
  20. Lechauve C, Chauvierre C, Dewilde S, Moens L, Green B, Marden M, et al. Cytoglobin conformations and disulfide bond formation. FEBS J. 2010;277:2696-704 pubmed publisher
    The oligomeric state and kinetics of ligand binding were measured for wild-type cytoglobin. Cytoglobin has the classical globin fold, with an extension at each extremity of about 20 residues...
  21. Sugimoto H, Makino M, Sawai H, Kawada N, Yoshizato K, Shiro Y. Structural basis of human cytoglobin for ligand binding. J Mol Biol. 2004;339:873-85 pubmed
    b>Cytoglobin (Cgb), a newly discovered member of the vertebrate globin family, binds O(2) reversibly via its heme, as is the case for other mammalian globins (hemoglobin (Hb), myoglobin (Mb) and neuroglobin (Ngb))...
  22. Trent J, Hargrove M. A ubiquitously expressed human hexacoordinate hemoglobin. J Biol Chem. 2002;277:19538-45 pubmed
    We have identified a new human hemoglobin that we call histoglobin because it is expressed in a wide array of tissues...
  23. McRonald F, Liloglou T, Xinarianos G, Hill L, Rowbottom L, Langan J, et al. Down-regulation of the cytoglobin gene, located on 17q25, in tylosis with oesophageal cancer (TOC): evidence for trans-allele repression. Hum Mol Genet. 2006;15:1271-7 pubmed
    ..5 kb minimal region. We now show that cytoglobin gene expression in oesophageal biopsies from tylotic patients is dramatically reduced by approximately 70% ..
  24. Sawai H, Kawada N, Yoshizato K, Nakajima H, Aono S, Shiro Y. Characterization of the heme environmental structure of cytoglobin, a fourth globin in humans. Biochemistry. 2003;42:5133-42 pubmed
    b>Cytoglobin (Cgb) represents a fourth member of the globin superfamily in mammals, but its function is unknown...
  25. Burmester T, Ebner B, Weich B, Hankeln T. Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues. Mol Biol Evol. 2002;19:416-21 pubmed
    ..It is expressed in apparently all types of human tissue and therefore has been called cytoglobin (CYGB). Mouse and human CYGBs comprise 190 amino acids; the zebrafish CYGB, 174 amino acids...
  26. Lin C, Hsu T, Chang Y, Huang B, Jiang L, Wang P, et al. Postoperative maintenance levonorgestrel-releasing intrauterine system for symptomatic uterine adenomyoma. Taiwan J Obstet Gynecol. 2018;57:47-51 pubmed publisher
    ..of adenomyosis-related dysmenorrhea, which was evaluated by the visual analog scale (VAS) and by hemoglobin (Hgb) and CA-125 levels...
  27. Figueroa Jiménez L, González Márquez A, Alicea Guevara R, Santiago Casiano M, de la Paz López M, Negrón Garcia L, et al. A Hispanic female patient with heartburn: A rare presentation of Paroxysmal Nocturnal Hemoglobinuria. Bol Asoc Med P R. 2015;107:9-12 pubmed
    ..CBC showed leukopenia (WBC 2.9 x 103 /µL) with neutropenia (segmented neutrophils 48%), macrocytic anemia (Hgb 6.1 g/dL, hematocrit 20%, MCV,113 fL) and thrombocytopenia (platelet count 59 x 109/L)...
  28. Wu M, Gong L, Qian C, Liang Z, Zeng W. Characteristics of blood chemistry, hematology, and lymphocyte subsets in pregnant rhesus monkeys. Chin J Nat Med. 2015;13:409-14 pubmed publisher
    ..05) were observed in HCT and RBC on GD20, GD150 and in HGB on GD150, Significant increases in NEUT and decreases in LYMPH on GD20 were observed...
  29. Shen M, Yu J, Wu D, Zhu D. An Efficient Adaptive Angle-Doppler Compensation Approach for Non-Sidelooking Airborne Radar STAP. Sensors (Basel). 2015;15:13121-31 pubmed publisher
    In this study, the effects of non-sidelooking airborne radar clutter dispersion on space-time adaptive processing (STAP) is considered, and an efficient adaptive angle-Doppler compensation (EAADC) approach is proposed to improve the ..
  30. Corti P, Ieraci M, Tejero J. Characterization of zebrafish neuroglobin and cytoglobins 1 and 2: Zebrafish cytoglobins provide insights into the transition from six-coordinate to five-coordinate globins. Nitric Oxide. 2016;53:22-34 pubmed publisher
    Neuroglobin (Ngb) and cytoglobin (Cygb) are two six-coordinate heme proteins of unknown physiological function...
  31. Rasenberg N, Fuit L, Poppe E, Kruijsen Terpstra A, Gorter K, Rathleff M, et al. The STAP-study: The (cost) effectiveness of custom made orthotic insoles in the treatment for plantar fasciopathy in general practice and sports medicine: design of a randomized controlled trial. BMC Musculoskelet Disord. 2016;17:31 pubmed publisher
    ..The results of this randomized controlled trial will improve the evidence base for treating this troublesome condition in daily practice. Dutch Trial Registration: NTR5346 . Date of registration: August 5(th) 2015. ..
  32. O Farrell N, Feighery R, Picardo S, Lynam Lennon N, Biniecka M, McGarrigle S, et al. Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence. BMC Cancer. 2016;16:497 pubmed publisher
    ..043) compared with esophageal adenocarcinoma tissue, along with increased expression of cytoglobin (CYGB) (p?<?0...
  33. Asahina K, Kawada N, Kristensen D, Nakatani K, Seki S, Shiokawa M, et al. Characterization of human stellate cell activation-associated protein and its expression in human liver. Biochim Biophys Acta. 2002;1577:471-5 pubmed
    ..Various types of cells including hepatic stellate cells expressed hSTAP mRNA. Recombinant hSTAP was a heme protein with the activity of peroxidase. hSTAP can be used as a marker of quiescent stellate cells in human liver. ..
  34. Chami N, Chen M, Slater A, Eicher J, Evangelou E, Tajuddin S, et al. Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. Am J Hum Genet. 2016;99:8-21 pubmed publisher
    ..3%, p = 2 × 10(-10) for hemoglobin [HGB]) and HNF4A (rs1800961, MAF = 2.4%, p < 3 × 10(-8) for hematocrit [HCT] and HGB)...
  35. van der Weijden F, van Loveren C, Slot D, van der Weijden G. [Preventive dentistry 4. Prevention and treatment of dentine hypersensitivity]. Ned Tijdschr Tandheelkd. 2017;124:133-139 pubmed publisher
    ..Behandeling kan het beste zo min mogelijk invasief plaatsvinden en bestaat als eerste stap uit het door de patiënt te laten tandenpoetsen en/of op de gevoelige plek te laten masseren met tandpasta’..
  36. Thuy L, Matsumoto Y, Thuy T, Hai H, Suoh M, Urahara Y, et al. Cytoglobin deficiency promotes liver cancer development from hepatosteatosis through activation of the oxidative stress pathway. Am J Pathol. 2015;185:1045-60 pubmed publisher
    This study was conducted to clarify the role of cytoglobin (Cygb), a globin expressed in hepatic stellate cells (HSCs), in the development of liver fibrosis and cancer in nonalcoholic steatohepatitis (NASH)...
  37. Oliveira K, da Conceição R, Piedade G, de Souza J, Sato M, de Barros Maciel R, et al. Thyroid hormone modulates neuroglobin and cytoglobin in rat brain. Metab Brain Dis. 2015;30:1401-8 pubmed publisher
    ..Two globins named neuroglobin (Ngb) and cytoglobin (Cygb) are located in the brain, and each one has different distribution and function: They seem to have similar ..
  38. Hedges A, Coons J, Saul M, Smith R. Clinical effectiveness and safety outcomes associated with prothrombin complex concentrates. J Thromb Thrombolysis. 2016;42:6-10 pubmed publisher
    ..Clinical outcomes of interest included time to achieve a target INR ≤1.3, time to Hgb >7 g/dL, and incidence of thromboembolism. A total of 143 patients were on warfarin (74...
  39. Abacı S, Alagoz S, Salihoglu A, Yalin S, Gulcicek S, Altiparmak M, et al. Assessment of Anemia and Quality of Life in Patients With Renal Transplantation. Transplant Proc. 2015;47:2875-80 pubmed publisher
    ..Anemia was defined by a hemoglobin (Hgb) level of <12 g/dL and severe anemia by a Hgb level of <10 g/dL...
  40. Völker M, Fiederer L, Berberich S, Hammer J, Behncke J, Kršek P, et al. The dynamics of error processing in the human brain as reflected by high-gamma activity in noninvasive and intracranial EEG. Neuroimage. 2018;173:564-579 pubmed publisher
    ..Neural activity in the high-gamma frequency band (HGB) closely reflects such local cortical processing, but little is known about its role in error processing, ..
  41. Oleksiewicz U, Liloglou T, Tasopoulou K, Daskoulidou N, Gosney J, Field J, et al. COL1A1, PRPF40A, and UCP2 correlate with hypoxia markers in non-small cell lung cancer. J Cancer Res Clin Oncol. 2017;143:1133-1141 pubmed publisher
    ..pre-mRNA Processing Factor (PRPF40A), and Uncoupling Protein 2 (UCP2) were identified as downstream effectors of cytoglobin (CYGB), which was shown implicated in tumour biology...
  42. Pan Y, Trojan J, Guo Y, Anthony D. Rescue of MHC-1 antigen processing machinery by down-regulation in expression of IGF-1 in human glioblastoma cells. PLoS ONE. 2013;8:e58428 pubmed publisher
    ..We addressed the question of alterations in this pathway in human Glioblastoma (HGB) and of its relationship to modulation in expression of IGF-1 that is highly expressed in this cancer...
  43. Tejero J, Kapralov A, Baumgartner M, Sparacino Watkins C, Anthonymutu T, Vlasova I, et al. Peroxidase activation of cytoglobin by anionic phospholipids: Mechanisms and consequences. Biochim Biophys Acta. 2016;1861:391-401 pubmed publisher
    b>Cytoglobin (Cygb) is a hexa-coordinated hemoprotein with yet to be defined physiological functions...
  44. Chichester L, Gee M, Jorgensen M, Kaplan J. Hematology and Clinical Chemistry Measures During and After Pregnancy and Age- and Sex-Specific Reference Intervals in African Green Monkeys (Chlorocebus aethiops sabaeus). J Am Assoc Lab Anim Sci. 2015;54:359-67 pubmed
    ..potassium, cholesterol, total CO2, globulins, lipase, amylase, WBC, neutrophils, lymphocytes, platelets, RBC, Hgb, and Hct occur during pregnancy and the postpartum period...
  45. Zhang J, Li H, Lu L, Yan L, Yang X, Shi Z, et al. The Yiqi and Yangyin Formula ameliorates injury to the hematopoietic system induced by total body irradiation. J Radiat Res. 2017;58:1-7 pubmed publisher
    ..5 Gy TBI. Furthermore, YYF treatment increased the white blood cell (WBC), red blood cell (RBC), hemoglobin (HGB) and hematocrit (HCT) counts in ICR mice exposed to 2 Gy or 4 Gy TBI...
  46. Le Guen Y, Leroy F, Auzias G, Riviere D, Grigis A, Mangin J, et al. The chaotic morphology of the left superior temporal sulcus is genetically constrained. Neuroimage. 2018;174:297-307 pubmed publisher
    ..The so-called superior temporal asymmetrical pit (STAP) area is observed from the last trimester of gestation onwards and is far less pronounced in the chimpanzee brain...
  47. Starek Świechowicz B, Miranowicz Dzierżawska K, Budziszewska B, Starek A. The effects of 2-methoxyethanol and 2-ethoxyethanol on hematological changes induced by 2-butoxyethanol. Med Pr. 2015;66:303-15 pubmed publisher
    ..Hematological analyses were performed on the day 0, 4, 11, 18, and 29. Hemoglobin (HGB) concentration in the urine was also determined in the rats treated with BE alone and co-exposed to BE and ME and ..
  48. Luo C, Luo X, He Y, Li J, Huang B, Lin L, et al. Impact of postoperative drainage autologous blood re-transfusion on the coagulation parameters and D-dimer levels of patients after total hip arthroplasty. Transfus Apher Sci. 2016;55:109-13 pubmed publisher
    ..drainage autologous blood re-transfusion (ABT) is an important treatment method that maintains a high haemoglobin (HGB) content and obviates the need for allogeneic blood transfusion in patients after surgery...
  49. Elsamadicy A, Adogwa O, Ongele M, Sergesketter A, Tarnasky A, Lubkin D, et al. Preoperative Hemoglobin Level is Associated with Increased Health Care Use After Elective Spinal Fusion (≥3 Levels) in Elderly Male Patients with Spine Deformity. World Neurosurg. 2018;112:e348-e354 pubmed publisher
    ..The lower hemoglobin (Hgb) level was designated as <13.5 g/dL. We identified 83 (40...
  50. Frey M, D Ippolito S, Pepe A, Daleo G, Guevara M. Transgenic expression of plant-specific insert of potato aspartic proteases (StAP-PSI) confers enhanced resistance to Botrytis cinerea in Arabidopsis thaliana. Phytochemistry. 2018;149:1-11 pubmed publisher
    The plant-specific insert of Solanum tuberosum aspartic proteases (StAP-PSI) has high structural similarity with NK-lysin and granulysin, two saposin-like proteins (SAPLIPs) with antimicrobial activity...
  51. Liang X, Li X, Sun H, Sun Z, Li Q, Yue Z, et al. Effects of nanocrystalline PbSe on hematopoietic system and bone marrow micronucleus rate of rats. Environ Toxicol Pharmacol. 2015;40:825-7 pubmed publisher
    ..with those of the control group, levels of erythrocyte mean corpuscular volume (MCV) in low dose group, hemoglobin (HGB), red blood cell specific volume (HCT), MCV in middle dose group and red blood cell (RBC), HGB, HCT, MCV in high ..
  52. Wormsbecker A, Sekhon M, Griesdale D, Wiskar K, Rush B. The association between anemia and neurological outcome in hypoxic ischemic brain injury after cardiac arrest. Resuscitation. 2017;112:11-16 pubmed publisher
    ..69 per 10 unit change in Hgb, 95% CI 0.54-0.88, p<0.01)...
  53. Bass L, Kim S, Superina R, Mohammad S. Jejunal varices diagnosed by capsule endoscopy in patients with post-liver transplant portal hypertension. Pediatr Transplant. 2017;21: pubmed publisher
    ..were identified at our institution presenting at a median age of 8 years (range 7-16 years) with a median Hgb of 2.8 g/dL (range 1.8-6.8 g/dL)...
  54. Halaç G, Kilic E, Cikrikcioglu M, Celik K, Toprak Erek A, Keskin S, et al. Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 levels in patients with restless legs syndrome. Bratisl Lek Listy. 2016;117:316-20 pubmed
    ..were similar in glucose, HbA1c, creatinine, LDL cholesterol, TG, HDL, total protein, albumin, AST, ALT, GGT, ALP, HGB, HCT, MCV, transferrin saturation rate (TSR), ferritin, CRP, TSH, FT4, FT3, B12, and folic acid levels...
  55. Amdahl M, Sparacino Watkins C, Corti P, Gladwin M, Tejero J. Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b5/Cytochrome b5 Reductase/NADH System. Biochemistry. 2017;56:3993-4004 pubmed publisher
    b>Cytoglobin is a heme-containing protein ubiquitous in mammalian tissues...
  56. Valderrábano R, Lee J, Lui L, Hoffman A, Cummings S, Orwoll E, et al. Older Men With Anemia Have Increased Fracture Risk Independent of Bone Mineral Density. J Clin Endocrinol Metab. 2017;102:2199-2206 pubmed publisher
    Extremely low hemoglobin (Hgb) values have been linked to increased fracture risk at different sites. However, careful assessment of clinically defined anemia and fracture risk is lacking.
  57. Oleksiewicz U, Liloglou T, Tasopoulou K, Daskoulidou N, Bryan J, Gosney J, et al. Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines. Hum Mol Genet. 2013;22:3207-17 pubmed publisher
    b>Cytoglobin (CYGB) is frequently downregulated in many types of human malignancies, and its exogenous overexpression reduces proliferation of cancer cells...
  58. Greene N, Jenkins H, Tollin D, EASTER J. Stapes displacement and intracochlear pressure in response to very high level, low frequency sounds. Hear Res. 2017;348:16-30 pubmed publisher
    ..of the cochlea far from the basilar membrane, increases directly proportionally with stapes displacement (DStap), thus a current model of impulse noise exposure (the Auditory Hazard Assessment Algorithm for Humans, or ..
  59. Johnson N, Rosselot B, Perman S, Dodampahala K, Goyal M, Gaieski D, et al. The association between hemoglobin concentration and neurologic outcome after cardiac arrest. J Crit Care. 2016;36:218-222 pubmed publisher
    The purpose of the study is to determine the association between hemoglobin concentration (Hgb) and neurologic outcome in postarrest patients...
  60. Ren X, Zhao T, Wang J, Zhu H, Jiang H, Jia J, et al. [Factors associated with early treatment response in adults with acute myeloid leukemia]. Zhonghua Xue Ye Xue Za Zhi. 2017;38:869-875 pubmed publisher
    ..In addition, low bone marrow blasts, HGB ? 80 g/L, PLT counts<30×10(9)/L and mutated NPM1 without FLT3-ITD were factors associated with achieving MLFS ..
  61. Guo X, Philipsen S, Tan Un K. Characterization of human cytoglobin gene promoter region. Biochim Biophys Acta. 2006;1759:208-15 pubmed
    b>Cytoglobin (CYGB) is a member of the vertebrate globin family together with hemoglobin, myoglobin and neuroglobin...
  62. John R, Chand V, Chakraborty S, Jaiswal N, Nag A. DNA damage induced activation of Cygb stabilizes p53 and mediates G1 arrest. DNA Repair (Amst). 2014;24:107-112 pubmed publisher
    b>Cytoglobin (Cygb) is an emerging tumor suppressor gene silenced by promoter hypermethylation in many human tumors. So far, the precise molecular mechanism underlying its tumor suppressive function remains poorly understood...
  63. Sibiya H, Musabayane C, Mabandla M. Transdermal delivery of oleanolic acid attenuates pro-inflammatory cytokine release and ameliorates anaemia in P. berghei malaria. Acta Trop. 2017;171:24-29 pubmed publisher
    ..Parasitaemia, HCT, RBC count, Hgb, plasma TNF-?, IL-6 and IL-10 concentrations were monitored in non-infected and infected rats following a once-off ..
  64. Li H, Hemann C, Abdelghany T, El Mahdy M, Zweier J. Characterization of the mechanism and magnitude of cytoglobin-mediated nitrite reduction and nitric oxide generation under anaerobic conditions. J Biol Chem. 2012;287:36623-33 pubmed publisher
    b>Cytoglobin (Cygb) is a recently discovered cytoplasmic heme-binding globin...
  65. Hamdane D, Kiger L, Dewilde S, Uzan J, Burmester T, Hankeln T, et al. Hyperthermal stability of neuroglobin and cytoglobin. FEBS J. 2005;272:2076-84 pubmed
    Neuroglobin (Ngb) and cytoglobin (Cygb), recent additions to the globin family, display a hexa-coordinated (bis-histidyl) heme in the absence of external ligands...
  66. Ochiai Y, Baba A, Hiramatsu M, Toyota N, Watanabe T, Yamashita K, et al. Blood biochemistry and hematological changes in rats after administration of a mixture of three anesthetic agents. J Vet Med Sci. 2017;: pubmed publisher
    ..transient increases were observed in glucose (GLUC) levels, hematocrit (HCT) values, and hemoglobin (HGB) levels, whereas transient decreases were observed in total protein (TP) content and white blood cell (WBC) counts...
  67. Robinson B, Larkina M, Bieber B, Kleophas W, Li Y, Locatelli F, et al. Evaluating the effectiveness of IV iron dosing for anemia management in common clinical practice: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). BMC Nephrol. 2017;18:330 pubmed publisher
    ..studies, our goal was to gain insight into optimal IV iron dosing by estimating the effects of IV iron doses on Hgb, TSAT, ferritin, and ESA dose in common clinical practice...
  68. Di Giulio C, Zara S, De Colli M, Ruffini R, Porzionato A, Macchi V, et al. Cytoglobin and neuroglobin in the human brainstem and carotid body. Adv Exp Med Biol. 2013;788:59-64 pubmed publisher
    The aim of the present study was to evaluate the presence of Neuroglobin (Ngb) and Cytoglobin (Cygb) in the solitary tract nucleus (STN) and in the carotid body of human subjects...
  69. He Y, Liu C, Zeng Z, Ye W, Lin J, Ou Q. Red blood cell distribution width: a potential laboratory parameter for monitoring inflammation in rheumatoid arthritis. Clin Rheumatol. 2018;37:161-167 pubmed publisher
    ..The white blood cell (WBC), red blood cell (RBC), platelet (PLT), hemoglobin (HGB), RDW, CRP, and ESR in peripheral blood of patients with RA were retrospectively analyzed...
  70. Raida Z, Reimets R, Hay Schmidt A, Hundahl C. Effect of permanent middle cerebral artery occlusion on Cytoglobin expression in the mouse brain. Biochem Biophys Res Commun. 2012;424:274-8 pubmed publisher
    b>Cytoglobin, a new member of the mammalian heme-globin family has been shown to bind oxygen and to have cell protective properties in vitro. Cytoglobin is specifically expressed in a subpopulation of brain neurons...
  71. Hünermund G, Schirmacher A, Ringelstein B, Young P, Watts G, Meuleman J, et al. Genomic organization and mutation analysis of three candidate genes for hereditary neuralgic amyotrophy. Muscle Nerve. 2004;29:601-4 pubmed
    ..of three candidate genes: sphingosine kinase 1 (SPHK1); tissue inhibitor of metalloproteinase 2 (TIMP2); and cytoglobin (CYGB)...
  72. Fago A, Rohlfing K, Petersen E, Jendroszek A, Burmester T. Functional diversification of sea lamprey globins in evolution and development. Biochim Biophys Acta. 2018;1866:283-291 pubmed publisher
    ..The sea lamprey (Petromyzon marinus) harbors at least 18 hemoglobin, two myoglobin, two globin X, and one cytoglobin genes. However, agnathan hemoglobins and myoglobins are not orthologous to their cognates in jawed vertebrates...
  73. Nandi S, Gov N. Nonequilibrium mode-coupling theory for dense active systems of self-propelled particles. Soft Matter. 2017;13:7609-7616 pubmed publisher
    ..that this long-time limit is captured by the potential energy of a single, trapped active particle (STAP)...
  74. Delgado Corcoran C, Frank D, Bodily S, Zhang C, Wolpert K, Lucas K, et al. Hemoglobin Level at Stage 1 Discharge has No Impact on Inter-stage Growth and Stability in Single Ventricle Infants. Pediatr Cardiol. 2017;: pubmed publisher
    Hemoglobin levels (Hgb) of infants with a single ventricle (SV) are traditionally maintained high to maximize oxygen-carrying capacity during stage 1 palliation (S1P), stage 2 palliation (S2P), and between stages (IS)...
  75. Saitoh K, Tsuchiya T, Kashiwakura J, Muromoto R, Kitai Y, Sekine Y, et al. STAP-2 interacts with Pyk2 and enhances Pyk2 activity in T-cells. Biochem Biophys Res Commun. 2017;488:81-87 pubmed publisher
    b>STAP-2 is an adaptor molecule regulating several signaling pathways, including TLRs and cytokine/chemokine receptors in immune cells. We previously reported that STAP-2 enhances SDF-1?-induced Vav1/Rac1-mediated T-cell chemotaxis...
  76. Wojnarowicz P, Provencher D, Mes Masson A, Tonin P. Chromosome 17q25 genes, RHBDF2 and CYGB, in ovarian cancer. Int J Oncol. 2012;40:1865-80 pubmed publisher
    ..The results combined suggest that RHBDF2 and CYGB may play distinctive roles in ovarian cancer and could be added to the growing roster of chromosome 17 genes implicated in this disease. ..
  77. Zhang S, Li X, Jourd heuil F, Qu S, Devejian N, Bennett E, et al. Cytoglobin Promotes Cardiac Progenitor Cell Survival against Oxidative Stress via the Upregulation of the NF?B/iNOS Signal Pathway and Nitric Oxide Production. Sci Rep. 2017;7:10754 pubmed publisher
    ..Recent studies suggest that the mammalian globin cytoglobin (CYGB) regulates nitric oxide (NO) metabolism and cell death...
  78. Sato Matsubara M, Matsubara T, Daikoku A, Okina Y, Longato L, Rombouts K, et al. Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling. J Biol Chem. 2017;: pubmed publisher
    b>Cytoglobin (CYGB) belongs to the mammalian globin family and is exclusively expressed in hepatic stellate cells (HSCs) in the liver...
  79. Kowanetz K, Husnjak K, Höller D, Kowanetz M, Soubeyran P, Hirsch D, et al. CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors. Mol Biol Cell. 2004;15:3155-66 pubmed
    ..We propose that CIN85 functions as a scaffold molecule that binds to numerous endocytic accessory proteins, thus controlling distinct steps in trafficking of EGF receptors along the endocytic and recycling pathways. ..
  80. Takeda S, Kuno R, Barbosa F, Gouveia N. Trace element levels in blood and associated factors in adults living in the metropolitan area of São Paulo, Brazil. J Trace Elem Med Biol. 2017;44:307-314 pubmed publisher
    ..Fish consumption was primarily related to increased blood Hg levels (HgB). Smokers exhibited 1.8 times more blood cadmium levels (CdB) than non-smokers...
  81. Kiger L, Tilleman L, Geuens E, Hoogewijs D, Lechauve C, Moens L, et al. Electron transfer function versus oxygen delivery: a comparative study for several hexacoordinated globins across the animal kingdom. PLoS ONE. 2011;6:e20478 pubmed publisher
    ..2) has been studied in comparison with human neuroglobin (Ngb) and cytoglobin (Cygb) for its electron transfer properties...
  82. Beckerson P, Wilson M, Svistunenko D, Reeder B. Cytoglobin ligand binding regulated by changing haem-co-ordination in response to intramolecular disulfide bond formation and lipid interaction. Biochem J. 2015;465:127-37 pubmed publisher
    b>Cytoglobin (Cygb) is a hexa-co-ordinate haem protein from the globin superfamily with a physiological function that is unclear...
  83. Zhao C, Zhang B, Du W. Effects of distal mutation on the dynamic properties of carboxycytoglobin: a molecular dynamics simulation study. J Biol Inorg Chem. 2013;18:947-55 pubmed publisher
    b>Cytoglobin (Cgb) is a hexacoordinate globin that plays various physiological roles, including O2 transport, enzyme activity, and lipid peroxidation...
  84. Tsujino H, Yamashita T, Nose A, Kukino K, Sawai H, Shiro Y, et al. Disulfide bonds regulate binding of exogenous ligand to human cytoglobin. J Inorg Biochem. 2014;135:20-7 pubmed publisher
    b>Cytoglobin (Cgb) was discovered a decade ago and is a fourth member of the group of hexacoordinated globin-folded proteins...
  85. Gabba M, Abbruzzetti S, Spyrakis F, Forti F, Bruno S, Mozzarelli A, et al. CO rebinding kinetics and molecular dynamics simulations highlight dynamic regulation of internal cavities in human cytoglobin. PLoS ONE. 2013;8:e49770 pubmed publisher
    b>Cytoglobin (Cygb) was recently discovered in the human genome and localized in different tissues...
  86. Chen H, Zhao X, Meng T. Expression and biological role of cytoglobin in human ovarian cancer. Tumour Biol. 2014;35:6933-9 pubmed publisher
    Loss of cytoglobin is found to be involved in the progression of several human cancers. However, its expression pattern and biological roles in human ovarian cancers are not clear...
  87. Hundahl C, Kelsen J, Hay Schmidt A. Neuroglobin and cytoglobin expression in the human brain. Brain Struct Funct. 2013;218:603-9 pubmed publisher
    Neuroglobin and cytoglobin are new members of the heme-globin family. Both globins are primarily expressed in neurons of the brain and retina...
  88. Kováčik A, Árvay J, Tusimova E, Harangozo Ľ, Tvrda E, Zbynovska K, et al. Seasonal variations in the blood concentration of selected heavy metals in sheep and their effects on the biochemical and hematological parameters. Chemosphere. 2017;168:365-371 pubmed publisher
    ..001), bilirubin (p < 0.05), triglycerides (p < 0.001) and a decrease of P (p < 0.05), HGB (p < 0.05), MCHC (p < 0.05) and RDWc (p < 0.05) in spring was detected...
  89. Sawai H, Makino M, Mizutani Y, Ohta T, Sugimoto H, Uno T, et al. Structural characterization of the proximal and distal histidine environment of cytoglobin and neuroglobin. Biochemistry. 2005;44:13257-65 pubmed
    b>Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ..
  90. Wu M, Chen N, Huang C, He Y, Zhao Y, Chen X, et al. Effect of Low Temperature on Globin Expression, Respiratory Metabolic Enzyme Activities, and Gill Structure of Litopenaeus vannamei. Biochemistry (Mosc). 2017;82:844-851 pubmed publisher
    ..The cDNA sequences of two oxygen-carrying proteins, cytoglobin (Cygb) and neuroglobin (Ngb), were isolated...
  91. da Conceição R, de Souza J, de Oliveira K, de Barros Maciel R, Romano M, Romano R, et al. Anatomical specificity of the brain in the modulation of Neuroglobin and Cytoglobin genes after chronic bisphenol a exposure. Metab Brain Dis. 2017;32:1843-1851 pubmed publisher
    The aim of this study was to investigate the influence of Bisphenol A (BPA) exposure on Neuroglobin (Ngb) and Cytoglobin (Cygb) as well as oxidative stress gene expression in the cerebellum, hippocampus, hypothalamus and cortex...
  92. Motoyama H, Komiya T, Thuy L, Tamori A, Enomoto M, Morikawa H, et al. Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver. Lab Invest. 2014;94:192-207 pubmed publisher
    b>Cytoglobin (CYGB) is ubiquitously expressed in the cytoplasm of fibroblastic cells in many organs, including hepatic stellate cells...