cytochrome P450 reductase

Summary

Gene Symbol: cytochrome P450 reductase
Description: cytochrome p450 oxidoreductase
Alias: CPR, CYPOR, P450R, NADPH--cytochrome P450 reductase, NADPH-dependent cytochrome P450 reductase, P450 (cytochrome) oxidoreductase
Species: human
Products:     cytochrome P450 reductase

Top Publications

  1. Gutierrez A, Paine M, Wolf C, Scrutton N, Roberts G. Relaxation kinetics of cytochrome P450 reductase: internal electron transfer is limited by conformational change and regulated by coenzyme binding. Biochemistry. 2002;41:4626-37 pubmed
    The kinetics of internal electron transfer in human cytochrome P450 reductase have been studied using temperature-jump relaxation spectroscopy...
  2. Hart S, Wang S, Nakamoto K, Wesselman C, Li Y, Zhong X. Genetic polymorphisms in cytochrome P450 oxidoreductase influence microsomal P450-catalyzed drug metabolism. Pharmacogenet Genomics. 2008;18:11-24 pubmed publisher
    ..Polymorphisms in the POR gene can affect POR and P450-catalyzed drug oxidation. These results suggest that POR has the potential to serve as a predictive biomarker for pharmacogenomic testing. ..
  3. Hershkovitz E, Parvari R, Wudy S, Hartmann M, Gomes L, Loewental N, et al. Homozygous mutation G539R in the gene for P450 oxidoreductase in a family previously diagnosed as having 17,20-lyase deficiency. J Clin Endocrinol Metab. 2008;93:3584-8 pubmed publisher
    ..POR deficiency can masquerade clinically as isolated 17,20-lyase deficiency. ..
  4. Fukami M, Nishimura G, Homma K, Nagai T, Hanaki K, Uematsu A, et al. Cytochrome P450 oxidoreductase deficiency: identification and characterization of biallelic mutations and genotype-phenotype correlations in 35 Japanese patients. J Clin Endocrinol Metab. 2009;94:1723-31 pubmed publisher
  5. Marohnic C, Huber Iii W, Patrick Connick J, Reed J, McCammon K, Panda S, et al. Mutations of human cytochrome P450 reductase differentially modulate heme oxygenase-1 activity and oligomerization. Arch Biochem Biophys. 2011;513:42-50 pubmed publisher
    Genetic variations in POR, encoding NADPH-cytochrome P450 oxidoreductase (CYPOR), can diminish the function of numerous cytochromes P450, and also have the potential to block degradation of heme by heme oxygenase-1 (HO-1)...
  6. Munro A, Noble M, Robledo L, Daff S, Chapman S. Determination of the redox properties of human NADPH-cytochrome P450 reductase. Biochemistry. 2001;40:1956-63 pubmed
    ..The redox properties of human cytochrome P450 reductase (CPR) are similar to those reported for rabbit CPR and the reductase domain of neuronal nitric oxide ..
  7. Barsukov I, Modi S, Lian L, Sze K, Paine M, Wolf C, et al. 1H, 15N and 13C NMR resonance assignment, secondary structure and global fold of the FMN-binding domain of human cytochrome P450 reductase. J Biomol NMR. 1997;10:63-75 pubmed
    The FMN-binding domain of human NADPH-cytochrome P450 reductase, corresponding to exons 3-7, has been expressed at high level in an active form and labelled with 13C and 15N...
  8. Wang J, de Montellano P. The binding sites on human heme oxygenase-1 for cytochrome p450 reductase and biliverdin reductase. J Biol Chem. 2003;278:20069-76 pubmed
    Human heme oxygenase-1 (hHO-1) catalyzes the NADPH-cytochrome P450 reductase-dependent oxidation of heme to biliverdin, CO, and free iron. The biliverdin is subsequently reduced to bilirubin by biliverdin reductase...
  9. Sahakitrungruang T, Huang N, Tee M, Agrawal V, Russell W, Crock P, et al. Clinical, genetic, and enzymatic characterization of P450 oxidoreductase deficiency in four patients. J Clin Endocrinol Metab. 2009;94:4992-5000 pubmed publisher
    ..P450 oxidoreductase (POR) deficiency causes disordered steroidogenesis; severe mutations cause genital ambiguity in both sexes plus the Antley-Bixler skeletal malformation syndrome, whereas mild mutations can cause adult infertility...

More Information

Publications95

  1. Adachi M, Tachibana K, Asakura Y, Yamamoto T, Hanaki K, Oka A. Compound heterozygous mutations of cytochrome P450 oxidoreductase gene (POR) in two patients with Antley-Bixler syndrome. Am J Med Genet A. 2004;128A:333-9 pubmed
    ..Our results demonstrate that mutations in POR cause the ABS phenotype with autosomal recessive inheritance and with characteristic abnormalities in steroidogenesis...
  2. Flück C, Tajima T, Pandey A, Arlt W, Okuhara K, Verge C, et al. Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome. Nat Genet. 2004;36:228-30 pubmed
    ..Mutations of POR also affect drug-metabolizing P450 enzymes, explaining the association of ABS with maternal fluconazole ingestion. ..
  3. Gomes A, Winter S, Klein K, Turpeinen M, Schaeffeler E, Schwab M, et al. Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation. Pharmacogenomics. 2009;10:579-99 pubmed publisher
    ..Intronic POR variants may influence microsomal CYP activities. These data provide a basis for further studies towards inclusion of POR polymorphisms in pharmacogenomic strategies. ..
  4. Arlt W, Walker E, Draper N, Ivison H, Ride J, Hammer F, et al. Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study. Lancet. 2004;363:2128-35 pubmed
    ..Deficiency of this enzyme could suggest an alternative pathway in human androgen synthesis, present only in fetal life, which explains the combination of antenatal androgen excess and postnatal androgen deficiency. ..
  5. Ellis J, Gutierrez A, Barsukov I, Huang W, Grossmann J, Roberts G. Domain motion in cytochrome P450 reductase: conformational equilibria revealed by NMR and small-angle x-ray scattering. J Biol Chem. 2009;284:36628-37 pubmed publisher
    NADPH-cytochrome P450 reductase (CPR), a diflavin reductase, plays a key role in the mammalian P450 mono-oxygenase system...
  6. Tomalik Scharte D, Maiter D, Kirchheiner J, Ivison H, Fuhr U, Arlt W. Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency. Eur J Endocrinol. 2010;163:919-24 pubmed publisher
    ..In patients with ORD, in vivo assessment of drug-metabolizing activities with subsequent tailoring of drug therapy and steroid replacement should be considered. ..
  7. Fukami M, Horikawa R, Nagai T, Tanaka T, Naiki Y, Sato N, et al. Cytochrome P450 oxidoreductase gene mutations and Antley-Bixler syndrome with abnormal genitalia and/or impaired steroidogenesis: molecular and clinical studies in 10 patients. J Clin Endocrinol Metab. 2005;90:414-26 pubmed
  8. Miller W, Agrawal V, Sandee D, Tee M, Huang N, Choi J, et al. Consequences of POR mutations and polymorphisms. Mol Cell Endocrinol. 2011;336:174-9 pubmed publisher
    ..The degree of activity can vary with the drug substrate assayed, as the drugs can influence the conformation of the P450. POR is probably an important contributor to genetic variation in both steroidogenesis and drug metabolism. ..
  9. Zhao Q, Modi S, Smith G, Paine M, McDonagh P, Wolf C, et al. Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 A resolution. Protein Sci. 1999;8:298-306 pubmed
    The crystal structure of the FMN-binding domain of human NADPH-cytochrome P450 reductase (P450R-FMN), a key component in the cytochrome P450 monooxygenase system, has been determined to 1...
  10. Bridges A, Gruenke L, Chang Y, Vakser I, Loew G, Waskell L. Identification of the binding site on cytochrome P450 2B4 for cytochrome b5 and cytochrome P450 reductase. J Biol Chem. 1998;273:17036-49 pubmed
    ..on the proximal surface of cytochrome P450, R422A and R443A, were shown to exhibit decreased binding to cytochrome P450 reductase. These studies indicate that the binding sites for cytochrome b5 and cytochrome P450 reductase are, as ..
  11. Pandey A, Kempna P, Hofer G, Mullis P, Flück C. Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase. Mol Endocrinol. 2007;21:2579-95 pubmed
    ..Because POR supports many P450s involved in steroidogenesis, bone formation, and drug metabolism, variations in the effects of POR mutations on specific enzyme activities may explain the broad clinical spectrum of POR deficiency. ..
  12. Grunau A, Geraki K, Grossmann J, Gutierrez A. Conformational dynamics and the energetics of protein--ligand interactions: role of interdomain loop in human cytochrome P450 reductase. Biochemistry. 2007;46:8244-55 pubmed
    ..SAXS) has been used to study the mechanism of ligand binding energy propagation through human cytochrome P450 reductase (CPR)...
  13. Grunau A, Paine M, Ladbury J, Gutierrez A. Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase. Biochemistry. 2006;45:1421-34 pubmed
    The thermodynamics of coenzyme binding to human cytochrome P450 reductase (CPR) and its isolated FAD-binding domain have been studied by isothermal titration calorimetry...
  14. Gutierrez A, Munro A, Grunau A, Wolf C, Scrutton N, Roberts G. Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues. Eur J Biochem. 2003;270:2612-21 pubmed
    The role of coenzyme binding in regulating interflavin electron transfer in human cytochrome P450 reductase (CPR) has been studied using temperature-jump spectroscopy. Previous studies [Gutierrez, A., Paine, M., Wolf, C.R., Scrutton, N.S...
  15. Gutierrez A, Lian L, Wolf C, Scrutton N, Roberts G. Stopped-flow kinetic studies of flavin reduction in human cytochrome P450 reductase and its component domains. Biochemistry. 2001;40:1964-75 pubmed
    The reduction by NADPH of the FAD and FMN redox centers in human cytochrome P450 reductase and its component domains has been studied by rapid-mixing, stopped-flow spectroscopy...
  16. Huang N, Agrawal V, Giacomini K, Miller W. Genetics of P450 oxidoreductase: sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations. Proc Natl Acad Sci U S A. 2008;105:1733-8 pubmed publisher
    ..The activity of A503V was reduced to a modest but statistically significant degree in all four assays, suggesting that it may play an important role in interindividual variation in drug response. ..
  17. Agrawal V, Huang N, Miller W. Pharmacogenetics of P450 oxidoreductase: effect of sequence variants on activities of CYP1A2 and CYP2C19. Pharmacogenet Genomics. 2008;18:569-76 pubmed publisher
    ..Thus, the activity of a POR mutant to support catalysis by a particular P450 enzyme cannot be predicted by the activity of that POR mutant in an assay with a different P450 or with cytochrome c. ..
  18. Huang N, Pandey A, Agrawal V, Reardon W, Lapunzina P, Mowat D, et al. Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis. Am J Hum Genet. 2005;76:729-49 pubmed
  19. Marohnic C, Panda S, McCammon K, Rueff J, Masters B, Kranendonk M. Human cytochrome P450 oxidoreductase deficiency caused by the Y181D mutation: molecular consequences and rescue of defect. Drug Metab Dispos. 2010;38:332-40 pubmed publisher
    ..2004) to harbor a 541T-->G mutation in exon 5 of POR (encoding NADPH-cytochrome P450 reductase, CYPOR), which resulted in a Y181D substitution that obliterated electron transfer capacity...
  20. de Jonge H, Metalidis C, Naesens M, Lambrechts D, Kuypers D. The P450 oxidoreductase *28 SNP is associated with low initial tacrolimus exposure and increased dose requirements in CYP3A5-expressing renal recipients. Pharmacogenomics. 2011;12:1281-91 pubmed publisher
    ..These data indicate that the POR*28 SNP is associated with additional increases in early tacrolimus dose-requirements in patients carrying a CYP3A5*1 allele. ..
  21. Dhir V, Ivison H, Krone N, Shackleton C, Doherty A, Stewart P, et al. Differential inhibition of CYP17A1 and CYP21A2 activities by the P450 oxidoreductase mutant A287P. Mol Endocrinol. 2007;21:1958-68 pubmed
    ..Differential interaction of POR with electron-accepting CYP enzymes may explain the phenotypic variability in POR deficiency, with additional implications for hepatic drug metabolism by POR-dependant CYP enzymes. ..
  22. Suwanchaichinda C, Brattsten L. Genomic and bioinformatic analysis of NADPH-cytochrome P450 reductase in Anopheles stephensi (Diptera: Culicidae). J Insect Sci. 2014;14:165 pubmed publisher
    ..The nicotinamide adenine dinucleotide phosphate (NADPH)-cytochrome P450 reductase (CPR) is required for transfer of electrons from NADPH to P450...
  23. Lee J, Kang M, Wang H, Naik G, Mobley J, Sonpavde G, et al. Endostatin inhibits androgen-independent prostate cancer growth by suppressing nuclear receptor-mediated oxidative stress. FASEB J. 2017;31:1608-1619 pubmed publisher
    ..ROS) scavenging machinery, including catalase, glutathione synthetase, glutathione reductase, NADPH-cytochrome P450 reductase, biliverdin reductase, and thioredoxin reductase, resulting in a concomitant reduction of intracellular ..
  24. dos Santos A, Conley A, De Oliveira M, Oliveira G, Viana D, Assis Neto A. Immunolocalization of steroidogenic enzymes in the vaginal mucous of Galea spixii during the estrous cycle. Reprod Biol Endocrinol. 2017;15:30 pubmed publisher
    ..estrogen synthesis, both of which must complex with the redox partner NADPH-cytochrome P450 oxidoreductase (CPR) for activity...
  25. Morales V. [Limitation of the therapeutic effort in pediatric intensive care]. Rev Chil Pediatr. 2015;86:56-60 pubmed publisher
    ..The removal or the non-installation of certain life support measures and the absence of CPR are the types of limitation most used...
  26. Bernhard M, Behrens N, Wnent J, Seewald S, Brenner S, Jantzen T, et al. Out-of-hospital airway management during manual compression or automated chest compression devices : A registry-based analysis. Anaesthesist. 2018;67:109-117 pubmed publisher
    ..Hospital admission under cardiopulmonary resuscitation (CPR), hospital admission with return of spontaneous circulation (ROSC), hospital discharge and discharge with cerebral ..
  27. Beskind D, Stolz U, Thiede R, Hoyer R, Robertson W, Brown J, et al. Viewing an ultra-brief chest compression only video improves some measures of bystander CPR performance and responsiveness at a mass gathering event. Resuscitation. 2017;118:96-100 pubmed publisher
    b>CPR training at mass gathering events is an important part of health initiatives to improve cardiac arrest survival...
  28. Agrawal V, Choi J, Giacomini K, Miller W. Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase. Pharmacogenet Genomics. 2010;20:611-8 pubmed publisher
    ..POR variants affect CYP3A4 activities. The impact of a POR variant on catalysis by CYP3A4 is substrate-specific, probably because of substrate-induced conformational changes in CYP3A4. ..
  29. González Salvado V, Abelairas Gomez C, Pena Gil C, Neiro Rey C, Barcala Furelos R, Gonzalez Juanatey J, et al. Basic life support training into cardiac rehabilitation programs: A chance to give back. A community intervention controlled manikin study. Resuscitation. 2018;127:14-20 pubmed publisher
    ..training (G-Stan) and a novel approach integrating cardiopulmonary resuscitation hands-on rolling refreshers (G-CPR) were randomly assigned to each group and compared...
  30. Backes W, Kelley R. Organization of multiple cytochrome P450s with NADPH-cytochrome P450 reductase in membranes. Pharmacol Ther. 2003;98:221-33 pubmed
    ..monooxygenase activity supported by NADPH requires an interaction between flavoprotein NADPH-cytochrome P450 reductase and cytochrome P450...
  31. Zhang X, Bian J, Li X, Wu X, Dong Y, You Q. 2-Substituted 3,7,8-trimethylnaphtho[1,2-b]furan-4,5-diones as specific L-shaped NQO1-mediated redox modulators for the treatment of non-small cell lung cancer. Eur J Med Chem. 2017;138:616-629 pubmed publisher
    ..substrate of the two-electron oxidoreductase NQO1 and could hardly be reduced by one-electron oxidoreductases CPR (NQO1/CPR = 20.8)...
  32. Fink K, Busch H. Effect of selenium on early outcomes after cardiopulmonary resuscitation : A preliminary report from a retrospective data evaluation. Med Klin Intensivmed Notfmed. 2018;: pubmed publisher
    ..we analyzed the influence of selenium treatment on the outcome of patients after cardiopulmonary resuscitation (CPR) following cardiac arrest...
  33. Dunn L, Sherrell H, Kumar S. Review: Systematic review of the utility of the fetal cerebroplacental ratio measured at term for the prediction of adverse perinatal outcome. Placenta. 2017;54:68-75 pubmed publisher
    This systematic review evaluates the utility of the fetal cerebroplacental ratio (CPR) when assessed at term (from 37 + 0 weeks gestation) as a predictor of adverse obstetric and perinatal outcomes...
  34. Maeda T, Yamashita A, Myojo Y, Wato Y, Inaba H. Augmented survival of out-of-hospital cardiac arrest victims with the use of mobile phones for emergency communication under the DA-CPR protocol getting information from callers beside the victim. Resuscitation. 2016;107:80-7 pubmed publisher
    ..of emergency calls made using mobile phones on the quality of dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) and survival from out-of-hospital cardiac arrests (OHCAs) that were not witnessed by emergency medical service (..
  35. Modisett K, Walsh S, Heffner A, Pearson D, Kerns W. Outcomes in Cardiac Arrest Patients due to Toxic Exposure Treated with Therapeutic Hypothermia. J Med Toxicol. 2016;12:263-9 pubmed publisher
    ..TICA were slightly younger, less likely to have an initial shockable rhythm, and less likely to receive bystander CPR as compared to non-toxic cases. TICA accounted for a significant proportion of patients in this study...
  36. Wang C, Huang C, Chang W, Tsai M, Yu P, Wu Y, et al. The influences of adrenaline dosing frequency and dosage on outcomes of adult in-hospital cardiac arrest: A retrospective cohort study. Resuscitation. 2016;103:125-130 pubmed publisher
    ..the influence of dosing frequency and dosage of adrenaline on outcomes of cardiopulmonary resuscitation (CPR)...
  37. Kudenchuk P, Stuart R, Husain S, Fahrenbruch C, Eisenberg M. Treatment and outcome of out-of-hospital cardiac arrest in outpatient health care facilities. Resuscitation. 2015;97:97-102 pubmed publisher
    ..Compared to home, more clinic arrests were witnessed, occurred after EMS arrival, had bystander CPR, shockable rhythms and were defibrillated...
  38. Jung J, Kwak Y, Kwon H, Choi Y, Kim D, Kim H, et al. Effectiveness of finger-marker for maintaining the correct compression point during paediatric resuscitation: A simulation study. Am J Emerg Med. 2017;35:1303-1308 pubmed publisher
    ..stickers for maintaining the correct compression point during simulated infant cardiopulmonary resuscitation (CPR)...
  39. Schneider K, Meeteer W, Nolan J, Campbell H. Health care in high school athletics in West Virginia. Rural Remote Health. 2017;17:3879 pubmed
    ..reported that all members of the coaching staff were certified in first aid and cardiac pulmonary resuscitation (CPR) and 31% reported 'never' when asked if all coaches were required to be certified in CPR and first aid...
  40. Perna S, Peroni G, Faliva M, Bartolo A, Naso M, Miccono A, et al. Sarcopenia and sarcopenic obesity in comparison: prevalence, metabolic profile, and key differences. A cross-sectional study in Italian hospitalized elderly. Aging Clin Exp Res. 2017;29:1249-1258 pubmed publisher
    ..S) had the mean value of erythrocyte sedimentation rate (ESR) (>15 mm/h), CPR (>0.50 mg/dl) homocysteine (>12 micromol/l), and hemoglobin (<12 g/dl)...
  41. Ocen D, Kalungi S, Ejoku J, Luggya T, Wabule A, Tumukunde J, et al. Prevalence, outcomes and factors associated with adult in hospital cardiac arrests in a low-income country tertiary hospital: a prospective observational study. BMC Emerg Med. 2015;15:23 pubmed publisher
    Research on cardiac arrest and cardiopulmonary resuscitation (CPR) has considerably increased in recent decades, and international guidelines for resuscitation have been implemented and have undergone several changes...
  42. Barrie A, Homburg R, McDowell G, Brown J, Kingsland C, Troup S. Embryos cultured in a time-lapse system result in superior treatment outcomes: a strict matched pair analysis. Hum Fertil (Camb). 2017;20:179-185 pubmed publisher
    ..The clinical (CPR), implantation (IR), live birth (LBR) and miscarriage rates (MR) were calculated and considered significant when pâ..
  43. Reeder B, David A. Health at hand: A systematic review of smart watch uses for health and wellness. J Biomed Inform. 2016;63:269-276 pubmed publisher
    ..One study focused on nursing work in the ICU and one focused on CPR training for laypeople. Consumer-grade smart watches have penetrated the health research space rapidly since 2014...
  44. Smereka J, Kamińska H, Wieczorek W, Dabrowski M, Ładny J, Ruetzler K, et al. Which position should we take during newborn resuscitation? A prospective, randomised, multicentre simulation trial. Kardiol Pol. 2018;76:980-986 pubmed publisher
    Early bystander cardiopulmonary resuscitation (CPR) for cardiac arrest is crucial in the chain of survival. Cardiac arrest in infants is rare, but CPR is also performed in severe bradycardia...
  45. Shahid A, Ali R, Ali N, Hasan S, Bernwal P, Afzal S, et al. Modulatory effects of catechin hydrate against genotoxicity, oxidative stress, inflammation and apoptosis induced by benzo(a)pyrene in mice. Food Chem Toxicol. 2016;92:64-74 pubmed publisher
    ..o.) increased the activities of toxicity markers such as LPO, LDH and B(a)P metabolizing enzymes [NADPH-cytochrome P450 reductase (CYPOR) and microsomal epoxide hydrolase (mEH)] with subsequent decrease in the activities of tissue ..
  46. Lim S, Aw S, Cheong M, Chew J, Ler A, Yong L, et al. A randomised control trial to compare retention rates of two cardiopulmonary resuscitation instruction methods in the novice. Resuscitation. 2016;103:82-87 pubmed publisher
    Studies show that after implementation of chest compression only CPR (CCC) in the community, there was an increase in bystander CPR rates and survival of OHCA victims...
  47. Santos Folgar M, Otero Agra M, Fernández Méndez F, Hermo Gonzalo M, Barcala Furelos R, Rodríguez Núñez A. [Ventilation during cardiopulmonary resuscitation in the infant. Mouth to mouth and nose, or bag-valve-mask? A quasi-experimental study]. An Pediatr (Barc). 2018;: pubmed publisher
    It has been observed that health professionals have difficulty performing quality cardiopulmonary resuscitation (CPR)...
  48. Rottenberg E. Are the current guideline recommendations for neonatal cardiopulmonary resuscitation safe and effective?. Am J Emerg Med. 2016;34:1658-60 pubmed publisher
    ..current recommendations and explored potential determinants of effective neonatal cardiopulmonary resuscitation (CPR). However, not all potential determinants of effective neonatal CPR were explored...
  49. Arnold W, Baylon J, Tajkhorshid E, Das A. Arachidonic Acid Metabolism by Human Cardiovascular CYP2J2 is Modulated by Doxorubicin. Biochemistry. 2017;: pubmed publisher
    ..Using kinetic analyses we show that AA metabolism by CYP2J2 is modulated by DOX. We show that cytochrome P450 reductase (CPR), the redox partner of CYP2J2, metabolizes DOX to 7-deoxydoxorubicin aglycone (7-de-aDOX)...
  50. Jung C, Janssen K, Kaluza M, Fuernau G, Poerner T, Fritzenwanger M, et al. Outcome predictors in cardiopulmonary resuscitation facilitated by extracorporeal membrane oxygenation. Clin Res Cardiol. 2016;105:196-205 pubmed publisher
    ..ECMO) in patients without return of spontaneous circulation (ROSC) by conventional cardiopulmonary resuscitation (CPR)...
  51. Mukai T, Reynolds N, Crnkovic A, Soll D. Bioinformatic Analysis Reveals Archaeal tRNATyr and tRNATrp Identities in Bacteria. Life (Basel). 2017;7: pubmed publisher
    ..Searching in recent genomic and metagenomic sequence data, we found some candidate phyla radiation (CPR) bacteria with archaeal tRNA identity for Tyr-tRNA and Trp-tRNA synthesis...
  52. Ikeda M, Swide T, Vayl A, Lahm T, Anderson S, Hutchens M. Estrogen administered after cardiac arrest and cardiopulmonary resuscitation ameliorates acute kidney injury in a sex- and age-specific manner. Crit Care. 2015;19:332 pubmed publisher
    ..estrogen to ovariectomized female mice ameliorated AKI after cardiac arrest and cardiopulmonary resuscitation (CA/CPR)...
  53. Girish M, Rawekar A, Jose S, Chaudhari U, Nanoti G. Utility of Low Fidelity Manikins for Learning High Quality Chest Compressions. Indian J Pediatr. 2018;85:184-188 pubmed publisher
    ..There were 34 (47.22%) male and 38 (52.77%) female participants. CPR skills, as judged by checklist of sequential actions and visual inspection during the BLS training on low fidelity ..
  54. Holschbach V, Weigert J, Dietrich J, Roesner S, Montag M, Strowitzki T, et al. Pregnancy rates of day 4 and day 5 embryos after culture in an integrated time-lapse incubator. Reprod Biol Endocrinol. 2017;15:37 pubmed publisher
    ..4% on day 4 versus 33.0% on day 5, p = 0.310; CPR 45.2% on day 4 versus 45.7% on day 5, p = 1.0)...
  55. Oh T, Park Y, Do S, Hwang J, Song I. ROSC rates and live discharge rates after cardiopulmonary resuscitation by different CPR teams - a retrospective cohort study. BMC Anesthesiol. 2017;17:166 pubmed publisher
    Previous studies have reported that the quality of cardiopulmonary resuscitation (CPR) is closely associated with patient outcomes...
  56. Clattenburg E, Wroe P, Brown S, Gardner K, Losonczy L, Singh A, et al. Point-of-care ultrasound use in patients with cardiac arrest is associated prolonged cardiopulmonary resuscitation pauses: A prospective cohort study. Resuscitation. 2018;122:65-68 pubmed publisher
    We aim to evaluate if point-of-care ultrasound use in cardiac arrest is associated with CPR pause duration...
  57. Guo J, Feng S, Wang B, Nie S, Li Y. [Effect of a stabilization device for maintaining the balance of a CPR performer during ambulance transportation on quality of CPR in out-of-hospital cardiac arrest: a prospective randomized controlled trial]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:940-942 pubmed publisher
    To investigate the effect of a stabilization device for maintaining the balance of a cardiopulmonary resuscitation (CPR) performer during ambulance transportation on quality of CPR in out-of-hospital cardiac arrest (OHCA).
  58. Zhao D, Guo Y, Sun Y, Liu H, Zhang Z, Ma Q, et al. Multi-detector spiral CT diagnosis of common bile duct ampullary carcinoma. Eur Rev Med Pharmacol Sci. 2017;21:3549-3553 pubmed
    ..plain scan and multi-phase enhanced scan with multi-planar reconstruction (MPR) and curved planar reconstruction (CPR) post-processing to obtain three-dimensional images...
  59. Ozalp C, Szczesna Skorupa E, Kemper B. Bimolecular fluorescence complementation analysis of cytochrome p450 2c2, 2e1, and NADPH-cytochrome p450 reductase molecular interactions in living cells. Drug Metab Dispos. 2005;33:1382-90 pubmed publisher
    ..These results demonstrate that BiFC is an effective method to study the complex protein interactions that occur within the microsomal P450 system in living cells...
  60. Segal N, Metzger A, Moore J, India L, Lick M, Berger P, et al. Correlation of end tidal carbon dioxide, amplitude spectrum area, and coronary perfusion pressure in a porcine model of cardiac arrest. Physiol Rep. 2017;5: pubmed publisher
    ..assessment of coronary perfusion pressure and myocardial perfusion during cardiopulmonary resuscitation (CPR)...
  61. Cariou G, Pelaccia T. Are they trained? Prevalence, motivations and barriers to CPR training among cohabitants of patients with a coronary disease. Intern Emerg Med. 2017;12:845-852 pubmed publisher
    ..Cardiopulmonary resuscitation (CPR) training of the next of kin of at-risk patients is thus potentially beneficial...
  62. Le Duff M, Ebramzadeh E, Amstutz H. Contact patch to rim distance: the quintessential tool for metal-on-metal bearing in vivo performance analysis - a review. Hip Int. 2017;27:220-225 pubmed publisher
    ..and the cup is close to the edge of the acetabular component, making the calculation of the contact patch to rim (CPR) distance a key variable in the study of the performance of MoM bearings...
  63. Pandey A, Flück C. NADPH P450 oxidoreductase: structure, function, and pathology of diseases. Pharmacol Ther. 2013;138:229-54 pubmed publisher
    ..The review is focused on the structural, enzymatic and clinical implications of the mutations linked to newly identified disorders in humans, now categorized as POR deficiency. ..
  64. Moore J, Segal N, Lick M, Dodd K, Salverda B, Hinke M, et al. Head and thorax elevation during active compression decompression cardiopulmonary resuscitation with an impedance threshold device improves cerebral perfusion in a swine model of prolonged cardiac arrest. Resuscitation. 2017;121:195-200 pubmed publisher
    As most cardiopulmonary resuscitation (CPR) efforts last longer than 15min, the aim of this study was to compare brain blood flow between the Head Up (HUP) and supine (SUP) body positions during a prolonged CPR effort of 15min, using ..
  65. Kim J, Park S, Lee K, Hong D, Baek K, Lee Y, et al. Video laryngoscopy vs. direct laryngoscopy: Which should be chosen for endotracheal intubation during cardiopulmonary resuscitation? A prospective randomized controlled study of experienced intubators. Resuscitation. 2016;105:196-202 pubmed publisher
    This study compared endotracheal intubation (ETI) performance during cardiopulmonary resuscitation (CPR) between direct laryngoscopy (DL) and video laryngoscopy (VL) (GlideScope(®)) by experienced intubators (>50 successful ETIs)...
  66. Heine T, Glatt H, Epe B. Human cytochrome P450 reductase can act as a source of endogenous oxidative DNA damage and genetic instability. Free Radic Biol Med. 2006;40:801-7 pubmed
    ..Here, we report that expression of human NADPH-cytochrome P450 reductase (hOR) in cultured V79 Chinese hamster cells gives rise to elevated basal levels of oxidative purine ..
  67. Smith A, ClinEpi C, Kumar S. The risk of preterm birth associated with a low cerebroplacental ratio. J Matern Fetal Neonatal Med. 2017;:1-131 pubmed publisher
    This paper investigated whether a cerebroplacental ratio (CPR) < 10th centile (measured between 23 + 0-36 + 0 weeks gestation) is predictive of any preterm birth, birth within 2 weeks of the ultrasound scan or spontaneous preterm ..
  68. . Initial Blood Ammonia Level Is a Useful Prognostication Tool in Out-of-Hospital Cardiac Arrest?- Multicenter Prospective Study (SOS-KANTO 2012 Study). Circ J. 2017;81:1839-1845 pubmed publisher
    ..47; 95% CI: 2.55-4.72), age<80 years (3.16; 95% CI: 2.17-4.61), bystander CPR (2.39; 95% CI: 1.70-3.38), and initial rhythm shockable (1.66; 95% CI: 1.16-2.37)...
  69. Aigrain L, Pompon D, Truan G. Role of the interface between the FMN and FAD domains in the control of redox potential and electronic transfer of NADPH-cytochrome P450 reductase. Biochem J. 2011;435:197-206 pubmed publisher
    CPR (NADPH-cytochrome P450 reductase) is a multidomain protein containing two flavin-containing domains joined by a connecting domain thought to control the necessary movements of the catalytic domains during electronic cycles...
  70. Danczak R, Johnston M, Kenah C, Slattery M, Wrighton K, Wilkins M. Members of the Candidate Phyla Radiation are functionally differentiated by carbon- and nitrogen-cycling capabilities. Microbiome. 2017;5:112 pubmed publisher
    The Candidate Phyla Radiation (CPR) is a recently described expansion of the tree of life that represents more than 15% of all bacterial diversity and potentially contains over 70 different phyla...
  71. Yukawa T, Kashiura M, Sugiyama K, Tanabe T, Hamabe Y. Neurological outcomes and duration from cardiac arrest to the initiation of extracorporeal membrane oxygenation in patients with out-of-hospital cardiac arrest: a retrospective study. Scand J Trauma Resusc Emerg Med. 2017;25:95 pubmed publisher
    ..The indication for ECPR for patients with OHCA should include several factors. However, the duration of CPR before the initiation of ECMO is a key factor and an independent factor for good neurological outcomes in patients ..
  72. Takahashi H, Sagisaka R, Natsume Y, Tanaka S, Takyu H, Tanaka H. Does dispatcher-assisted CPR generate the same outcomes as spontaneously delivered bystander CPR in Japan?. Am J Emerg Med. 2018;36:384-391 pubmed publisher
    We investigated whether DA-CPR would have the same effect as spontaneously-delivered bystander CPR...
  73. Singer A, Nguyen R, Ravishankar S, Schoenfeld E, Thode H, Henry M, et al. Cerebral oximetry versus end tidal CO2 in predicting ROSC after cardiac arrest. Am J Emerg Med. 2018;36:403-407 pubmed publisher
    ..oxygen saturations (rSO2) have been studied to determine their ability to monitor the effectiveness of CPR and predict return of spontaneous circulation (ROSC)...
  74. Wang L, Song W, Zhang S. [Chest compression on CPR and active abdominal on CPR]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:1057-1061 pubmed publisher
    ..Active abdominal compression-decompression cardiopulmonary resuscitation (AACD-CPR) could reach better resuscitation outcomes in certain cardiac arrest (CA) patients...
  75. Sato R, Kuriyama A, Nasu M, Gima S, Iwanaga W, Takada T, et al. Impact of rapid response car system on ECMO in out-of-hospital cardiac arrest: A retrospective cohort study. Am J Emerg Med. 2018;36:442-445 pubmed publisher
    ..life support (ECLS) has been reported to be more effective than conventional cardiopulmonary resuscitation (CPR)...
  76. Magnet I, Ettl F, Schober A, Warenits A, Grassmann D, Wagner M, et al. Extracorporeal Life Support Increases Survival After Prolonged Ventricular Fibrillation Cardiac Arrest in the Rat. Shock. 2017;48:674-680 pubmed publisher
    Extracorporeal life support (ECLS) for cardiopulmonary resuscitation (CPR) may increase end organ perfusion and thus survival when conventional CPR fails...
  77. Pecoraro F, Gloekler S, Mader C, Roos M, Chaykovska L, Veith F, et al. Mortality rates and risk factors for emergent open repair of abdominal aortic aneurysms in the endovascular era. Updates Surg. 2018;70:129-136 pubmed publisher
    ..as a preoperative diagnostic tool, AAA rupture, preoperative shock, intraoperative cardiopulmonary resuscitation (CPR), use of aortic balloon occlusion, intraoperative massive blood transfusion (MBT), and development of abdominal ..
  78. Birkun A, Glotov M. Education in cardiopulmonary resuscitation in Russia: A systematic review of the available evidence. World J Emerg Med. 2017;8:245-252 pubmed publisher
    To summarise and appraise cumulative published scientific evidence relevant to cardiopulmonary resuscitation (CPR) education in Russia.
  79. Koster R, Beenen L, van der Boom E, Spijkerboer A, Tepaske R, van der Wal A, et al. Safety of mechanical chest compression devices AutoPulse and LUCAS in cardiac arrest: a randomized clinical trial for non-inferiority. Eur Heart J. 2017;38:3006-3013 pubmed publisher
    Mechanical chest compression (CC) during cardiopulmonary resuscitation (CPR) with AutoPulse or LUCAS devices has not improved survival from cardiac arrest. Cohort studies suggest risk of excess damage...
  80. Tomková M, Panda S, Šeda O, Baxová A, Hůlková M, Siler Masters B, et al. Genetic variations in NADPH-CYP450 oxidoreductase in a Czech Slavic cohort. Pharmacogenomics. 2015;16:205-15 pubmed publisher
    ..Original submitted 15 September 2014; Revision submitted 17 November 2014. ..
  81. Hoyme D, Atkins D. Implementing Cardiopulmonary Resuscitation Training Programs in High Schools: Iowa's Experience. J Pediatr. 2017;181:172-176.e3 pubmed publisher
    To understand perceived barriers to providing cardiopulmonary resuscitation (CPR) education, implementation processes, and practices in high schools. Iowa has required CPR as a graduation requirement since 2011 as an unfunded mandate...
  82. Chowdhury A, Fernandes B, Melhuish T, White L. Antiarrhythmics in Cardiac Arrest: A Systematic Review and Meta-Analysis. Heart Lung Circ. 2018;27:280-290 pubmed publisher
    It is widely accepted that antiarrhythmics play a role in cardiopulmonary resuscitation (CPR) universally, but the absolute benefit of antiarrhythmic use and the drug of choice in advanced life support remains controversial...
  83. Brignac Huber L, Park J, Reed J, Backes W. Cytochrome P450 Organization and Function Are Modulated by Endoplasmic Reticulum Phospholipid Heterogeneity. Drug Metab Dispos. 2016;44:1859-1866 pubmed
    ..These studies have shown that P450s and NADPH-cytochrome P450 reductase appear to selectively associate with specific phospholipids and that these lipid-protein interactions ..
  84. Nour S, Carbognani D, Chachques J. Circulatory Flow Restoration Versus Cardiopulmonary Resuscitation: New Therapeutic Approach in Sudden Cardiac Arrest. Artif Organs. 2017;41:E356-E366 pubmed publisher
    ..Insufficiencies of current cardiopulmonary resuscitation (CPR) are most probably related to an inappropriate concept and applied methods that still concentrate on heartbeat as ..
  85. Rouck J, Biggs B, Kambalyal A, Arnold W, De Mey M, Ajikumar P, et al. Heterologous expression and characterization of plant Taxadiene-5α-Hydroxylase (CYP725A4) in Escherichia coli. Protein Expr Purif. 2017;132:60-67 pubmed publisher
    ..All six of these constructs are N-terminally modified and three of them are fused to cytochrome P450 reductase to form a chimera construct...
  86. Scott R, Miller W. Genetic and clinical features of p450 oxidoreductase deficiency. Horm Res. 2008;69:266-75 pubmed publisher
    ..Given the varied physical and biochemical phenotype of POR deficiency and the risk of adrenal insufficiency, clinicians should be alert to this potential diagnosis. ..