cytochrome c oxidase subunit VIII

Summary

Gene Symbol: cytochrome c oxidase subunit VIII
Description: cytochrome c oxidase subunit 8A
Alias: COX, COX8, COX8-2, COX8L, VIII, VIII-L, cytochrome c oxidase subunit 8A, mitochondrial, cytochrome c oxidase polypeptide VIII-liver/heart, cytochrome c oxidase subunit 8-2, cytochrome c oxidase subunit 8A (ubiquitous), cytochrome c oxidase subunit VIII, cytochrome c oxidase subunit VIIIA (ubiquitous)
Species: human

Top Publications

  1. Dong L, Han X, Tao X, Xu L, Xu Y, Fang L, et al. Protection by the Total Flavonoids from Rosa laevigata Michx Fruit against Lipopolysaccharide-Induced Liver Injury in Mice via Modulation of FXR Signaling. Foods. 2018;7: pubmed publisher
    ..decreased the expression levels of IL (interleukin)-1β, IL-6, HMGB-1 (high -mobility group box 1), and COX-2 (cyclooxygenase-2) by activating FXR and FOXO3a (forkhead box O3) against inflammation...
  2. Rueda E, Johnson J, Giddabasappa A, Swaroop A, Brooks M, Sigel I, et al. The cellular and compartmental profile of mouse retinal glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and ~P transferring kinases. Mol Vis. 2016;22:847-85 pubmed
    ..Quantitative cytochrome oxidase (COX) and lactate dehydrogenase (LDH) activity was determined histochemically...
  3. Gao P, Yang B, Yu H, Meng R, Si J. Carvedilol alleviates the biliary cirrhosis through inhibiting the endoplasmic reticulum stress. Eur Rev Med Pharmacol Sci. 2017;21:5813-5820 pubmed publisher
    ..mRNA expression levels of pro-inflammatory factors, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), transforming growth factor ?-1 (TGF-?1), ?-SMA and collagen-1 were detected via reverse transcription-..
  4. Zhao X, Sun P, Li G, Yi R, Qian Y, Park K. Polyphenols in Kuding tea help prevent HCl/ethanol-induced gastric injury in mice. Food Funct. 2018;9:1713-1725 pubmed publisher
    ..nuclear factor ?-light-chain-enhancer of activated B cells (NF-?B), inducible NOS (iNOS), and cyclooxygenase-2 (COX-2) was weaker in the HKTP group than in the control group...
  5. Udina M, Navines R, Egmond E, Oriolo G, Langohr K, Gimenez D, et al. Glucocorticoid Receptors, Brain-Derived Neurotrophic Factor, Serotonin and Dopamine Neurotransmission are Associated with Interferon-Induced Depression. Int J Neuropsychopharmacol. 2016;19: pubmed publisher
    ..A survival analysis was performed, and the Cox proportional hazards model was used for the multivariate analysis. The cumulative incidence of depression was 0...
  6. Liu Q, Zhang C, Li Q, Zhu Y, Zhang D, Zhao W, et al. [Analysis of prognosis and associated risk factors in pediatric idiopathic pulmonary arterial hypertension]. Zhonghua Er Ke Za Zhi. 2018;56:23-28 pubmed publisher
    ..Kaplan-Meier survival curve was used to assess the survival,and the COX risk regression model was used to analyze the prognostic risk factors...
  7. Yang X, Yuan L, Xiong C, Yin C, Ruan J. Abacopteris penangiana exerts testosterone-induced benign prostatic hyperplasia protective effect through regulating inflammatory responses, reducing oxidative stress and anti-proliferative. J Ethnopharmacol. 2014;157:105-13 pubmed publisher
    ..In addition, the relative inflammatory factors, cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β), interleukin 6 (IL-6), interleukin 8 (IL-8) ..
  8. Xu B, Kong X, Xu R, Song Y, Liu L, Zhou Z, et al. Homocysteine and all-cause mortality in hypertensive adults without pre-existing cardiovascular conditions: Effect modification by MTHFR C677T polymorphism. Medicine (Baltimore). 2017;96:e5862 pubmed publisher
    ..Hazard ratios (HRs) and 95% confidence intervals were estimated by Cox proportional-hazard regression models, adjusting for age, sex, baseline folate, vitamin B12, blood pressure, body ..
  9. Lin C, Lee H, Lee M, Pan S, Ke C, Chiu A, et al. Role of Mitochondrial DNA Copy Number Alteration in Human Renal Cell Carcinoma. Int J Mol Sci. 2016;17: pubmed publisher
    ..levels of TFAM; mtDNA-encoded NADH dehydrogenase subunit 1 (ND1), ND6 and cytochrome c oxidase subunit 2 (COX-2); nuclear DNA (nDNA)-encoded succinate dehydrogenase subunit A (SDHA); v-akt murine thymoma viral oncogene ..

More Information

Publications156 found, 100 shown here

  1. Wang X, Cheng Y, Xue H, Yue Y, Zhang W, Li X. Fargesin as a potential β₁ adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis. Fitoterapia. 2015;105:16-25 pubmed publisher
    ..Moreover, compared with the I/R group, fargesin increased COX release and the activities of some endogenous antioxidative enzymes including superoxide dismutase (SOD), catalase (..
  2. Cen C, Aziz M, Yang W, Zhou M, Nicastro J, Coppa G, et al. Milk fat globule-epidermal growth factor-factor VIII attenuates sepsis-induced acute kidney injury. J Surg Res. 2017;213:281-289 pubmed publisher
    ..Milk fat globule-epidermal growth factor-factor VIII (MFG-E8) is a secretory glycoprotein with a known role in the enhancement of apoptotic cell clearance and ..
  3. GÄ…dek Michalska A, Tadeusz J, Rachwalska P, Bugajski J. Cytokines, prostaglandins and nitric oxide in the regulation of stress-response systems. Pharmacol Rep. 2013;65:1655-62 pubmed
    ..In the central nervous system (CNS), prostaglandins (PG) generated by the cyclooxygenase (COX) enzyme are involved in the regulation of HPA axis activity...
  4. Kaur T, Borse V, Sheth S, Sheehan K, Ghosh S, Tupal S, et al. Adenosine A1 Receptor Protects Against Cisplatin Ototoxicity by Suppressing the NOX3/STAT1 Inflammatory Pathway in the Cochlea. J Neurosci. 2016;36:3962-77 pubmed publisher
    ..the expression of STAT1 target genes, such as TNF-?, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and reduced cisplatin-mediated apoptosis...
  5. Hippisley Cox J, Coupland C. Development and validation of QMortality risk prediction algorithm to estimate short term risk of death and assess frailty: cohort study. BMJ. 2017;358:j4208 pubmed publisher
    ..50 million patients in the validation cohort.Methods Cox proportional hazards models in the derivation cohort were used to derive separate risk equations in men and women ..
  6. Suo H, Zhao X, Qian Y, Sun P, Zhu K, Li J, et al. Lactobacillus fermentum Suo Attenuates HCl/Ethanol Induced Gastric Injury in Mice through Its Antioxidant Effects. Nutrients. 2016;8:155 pubmed publisher
    ..endothelial nitric oxide synthase), Mn-SOD, Cu/Zn-SOD, CAT (catalase) mRNA or protein expressions and reduced the COX-2, NF-κB (nuclear factor kappaB), and iNOS (inducible nitric oxide synthase) expressions in gastric tissues ..
  7. Pan Y, Luo Z, Zhuo M, Wei C, Chen G, Song Y. Oxidative stress and mitochondrial dysfunction mediated Cd-induced hepatic lipid accumulation in zebrafish Danio rerio. Aquat Toxicol. 2018;199:12-20 pubmed publisher
    ..The activities of superoxide dismutase (SOD), glutathoinine peroxidase (GPx) and cytochrome c oxidase (COX) and the ATP level were significantly reduced after CdCl2 exposure...
  8. Lin C, Liu L, Ou L, Pan S, Lin C, Wei Y. Role of mitochondrial function in the invasiveness of human colon cancer cells. Oncol Rep. 2018;39:316-330 pubmed publisher
    ..and mitochondrial DNA (mtDNA)-encoded NADH dehydrogenase subunit 6 (ND6) and cytochrome c oxidase subunit II (COX-II) and nuclear DNA-encoded NADH ubiquinone oxidoreductase subunit A9 (NDUFA9), iron-sulfur protein subunit B of ..
  9. Kandemir F, Yildirim S, Kucukler S, Caglayan C, Mahamadu A, Dortbudak M. Therapeutic efficacy of zingerone against vancomycin-induced oxidative stress, inflammation, apoptosis and aquaporin 1 permeability in rat kidney. Biomed Pharmacother. 2018;105:981-991 pubmed publisher
    ..prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), myeloperoxidase (MPO) and cyclooxygenase-2 (COX-2)...
  10. Bellaver B, Souza D, Souza D, Quincozes Santos A. Hippocampal Astrocyte Cultures from Adult and Aged Rats Reproduce Changes in Glial Functionality Observed in the Aging Brain. Mol Neurobiol. 2017;54:2969-2985 pubmed publisher
    ..cytokine levels, such as TNF-?, IL-1?, IL-6, IL-18, and messenger RNA (mRNA) levels of cyclo-oxygenase 2 (COX-2)...
  11. Murphy S, Zweyer M, Henry M, Meleady P, Mundegar R, Swandulla D, et al. Proteomic analysis of the sarcolemma-enriched fraction from dystrophic mdx-4cv skeletal muscle. J Proteomics. 2018;: pubmed publisher
    ..reactive myofibrosis, (vii) disturbed ion homeostasis at the sarcolemma and associated membrane systems, and (viii) a robust inflammatory response by the innate immune system in response to chronic muscle damage...
  12. Hwang J, Kumar V, Kang S, Jung H, Park Y. Effects of Flower Buds Extract of Tussilago farfara on Focal Cerebral Ischemia in Rats and Inflammatory Response in BV2 Microglia. Chin J Integr Med. 2018;: pubmed publisher
    ..Nitric oxide (NO) production was measured in culture medium by Griess assay. The expressions of iNOS, COX-2 and pro-inflammatory cytokines mRNA were analyzed by reverse transcription-polymerase chain reaction...
  13. Baba S, Aydın M. [Investigation of the serotype distribution, biofilm production and antibiotic susceptibilities of group B streptococci isolated from urinary samples]. Mikrobiyol Bul. 2016;50:353-60 pubmed
    ..7%), III (n= 9; 15%), Ib (n= 3; 5%), VI (n= 1; 1.7%) and VII (n= 1; 1.7%). Serotype IV, VIII and IX were not detected, while four (6.7%) isolates were untypeable. Serotype V (13/40; 32...
  14. Czekaj R, Majka J, Ptak Belowska A, Szlachcic A, Targosz A, Magierowska K, et al. Role of curcumin in protection of gastric mucosa against stress-induced gastric mucosal damage. Involvement of hypoacidity, vasoactive mediators and sensory neuropeptides. J Physiol Pharmacol. 2016;67:261-75 pubmed
    ..of mRNA for tumor necrosis factor-? (TNF-?), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in gastric mucosa was evaluated by reverse transcription polymerase chain reaction (RT-PCR)...
  15. Huang Y, Zhou J, Qu C, Dou Y, Huang Q, Lin Z, et al. Anti-inflammatory effects of Brucea javanica oil emulsion by suppressing NF-?B activation on dextran sulfate sodium-induced ulcerative colitis in mice. J Ethnopharmacol. 2017;198:389-398 pubmed publisher
    ..The mRNA expression of MPO, iNOS and COX-2 in colon tissues was detected by qRT-PCR...
  16. Martinez C, Piagette J, Escobar A, Martin A, Palacios R, Peçanha F, et al. Aluminum exposure at human dietary levels promotes vascular dysfunction and increases blood pressure in rats: A concerted action of NAD(P)H oxidase and COX-2. Toxicology. 2017;390:10-21 pubmed publisher
    ..channels blocker TEA, the NAD(P)H oxidase inhibitor apocynin, superoxide dismutase (SOD), the non-selective COX inhibitor indomethacin and the selective COX-2 inhibitor NS 398 were analyzed...
  17. Wang H, Xu Y, Wang M, Cheng C, Bian R, Yuan H, et al. Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders. Int J Mol Med. 2017;39:819-830 pubmed publisher
    ..IL-6, tumor necrosis factor (TNF)-?, HMGB1, high mobility group box 1 protein (HMGB1), cyclooxygenase-2 (COX-2), the Toll-like receptor 4 (TLR4)-myeloid differentiation factor 88 (MyD88)-TNF receptor?associated factor 6..
  18. Brzozowska I, Strzalka M, Drozdowicz D, Konturek S, Brzozowski T. Mechanisms of esophageal protection, gastroprotection and ulcer healing by melatonin. implications for the therapeutic use of melatonin in gastroesophageal reflux disease (GERD) and peptic ulcer disease. Curr Pharm Des. 2014;20:4807-15 pubmed
    ..in healing rate of gastric ulcers may involve the gastroprotective factors derived from the activation of PG/COX and NO/NOS systems as well as gastrin which also was shown to exhibit protective and trophic effects in the upper ..
  19. Taranu I, Gras M, Pistol G, Motiu M, Marin D, Lefter N, et al. ω-3 PUFA rich camelina oil by-products improve the systemic metabolism and spleen cell functions in fattening pigs. PLoS ONE. 2014;9:e110186 pubmed publisher
    ..tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and interleukin (IL-8) and cyclooxigenase 2 (COX-2) in comparison with T1 diet. By contrast, T2 diet increased (P<0...
  20. Urrunaga N, Magder L, Weir M, Rockey D, Mindikoglu A. Prevalence, Severity, and Impact of Renal Dysfunction in Acute Liver Failure on the US Liver Transplant Waiting List. Dig Dis Sci. 2016;61:309-16 pubmed publisher
    ..were determined and the association between renal dysfunction and waiting list mortality was assessed using Cox proportional hazard regression analysis...
  21. Siddiqui F, Naqvi S, Abidi L, Faizi S, Lubna -, Avesi L, et al. Opuntia dillenii cladode: Opuntiol and opuntioside attenuated cytokines and eicosanoids mediated inflammation. J Ethnopharmacol. 2016;182:221-34 pubmed publisher
    ..Opuntiol (aglycone) emerged as a dual inhibitor of cyclooxygenase (COX) and lipooxygenase (LOX) pathways. It also suppressed ROS and cytokine levels...
  22. Younis T, Khan M, Sajid M. Protective effects of Fraxinus xanthoxyloides (Wall.) leaves against CCl4 induced hepatic toxicity in rat. BMC Complement Altern Med. 2016;16:407 pubmed
    ..Group VII and VIII was administered with FXM (200, 400 mg/kg bw) alone (15 dosages)...
  23. Nandi A, Wadhwani N, Joshi S. Altered metabolic homeostasis between vitamin D and long chain polyunsaturated fatty acids in preeclampsia. Med Hypotheses. 2017;100:31-36 pubmed publisher
    ..ROS) production which in turn leads to increased expression of phospholipase A2 (PLA2) and cyclooxygenase-2 (COX-2)...
  24. Insuela D, Daleprane J, Coelho L, Silva A, e Silva P, Martins M, et al. Glucagon induces airway smooth muscle relaxation by nitric oxide and prostaglandin Eâ‚‚. J Endocrinol. 2015;225:205-17 pubmed publisher
    ..of glucagon receptor (GcgR), CREB, phospho-CREB, nitric oxide synthase (NOS)-3, pNOS-3 and cyclooxygenase (COX)-1 was evaluated by western blot, while prostaglandin E₂ (PGE₂) and tumour necrosis factor-α were ..
  25. Tasaki T, Yamada S, Nabeshima A, Noguchi H, Nawata A, Hisaoka M, et al. An autopsy case of myocardial infarction due to idiopathic thrombotic thrombocytopenic purpura. Diagn Pathol. 2015;10:52 pubmed publisher
    ..and capillaries were platelet thrombi, which showed positive results for periodic acid-Schiff stain and factor VIII on immunohistochemical staining...
  26. Guo J, Zu G, Zhou T, Xing J, Wang Z. Clinicopathological significance of orphan nuclear receptor Nurr1 expression in gastric cancer. Clin Transl Oncol. 2015;17:788-94 pubmed publisher
    ..Univariate and multivariate survival analyses with a Cox's proportional hazards regression model were used to identify independent factors related to recurrence and ..
  27. Huguet A, Latournerie M, Debry P, Jezequel C, Legros L, Rayar M, et al. The psoas muscle transversal diameter predicts mortality in patients with cirrhosis on a waiting list for liver transplantation: A retrospective cohort study. Nutrition. 2018;51-52:73-79 pubmed publisher
    ..Area under the receiver operating characteristic curve (AUC) and Cox proportional hazard models were assessed. TPTI and APTI interobserver agreement: ? correlation test...
  28. Fajardo A, Piazza G. Chemoprevention in gastrointestinal physiology and disease. Anti-inflammatory approaches for colorectal cancer chemoprevention. Am J Physiol Gastrointest Liver Physiol. 2015;309:G59-70 pubmed publisher
    ..by anti-inflammatory agents including nonsteroidal anti-inflammatory drugs (NSAIDs), selective cyclooxygenase-2 (COX-2) inhibitors, and natural products is an area of considerable interest and research...
  29. Yatsu S, Naito R, Kasai T, Matsumoto H, Shitara J, Shimizu M, et al. Influence of sleep-disordered breathing assessed by pulse oximetry on long-term clinical outcomes in patients who underwent percutaneous coronary intervention. Clin Res Cardiol. 2018;107:711-718 pubmed publisher
    ..0134). In the stepwise multivariable Cox proportional model, the presence of SDB was a significant predictor of MACCE (hazard ratio 2...
  30. Brunetti L, Lee S, Doherty N, Suh D, Kim J, Lee S, et al. Impact of warfarin discharge education program on hospital readmission and treatment costs. Int J Clin Pharm. 2018;40:721-729 pubmed publisher
    ..The effects of the WDEP on readmission within 90 days after discharge were analyzed using Cox proportional hazards models...
  31. Holmes J, Driscoll A, Heron M. Mortality among US-born and immigrant Hispanics in the US: effects of nativity, duration of residence, and age at immigration. Int J Public Health. 2015;60:609-17 pubmed publisher
    ..We used Cox proportional hazard models to examine the effects of duration of US residence and age at immigration on mortality ..
  32. Park S, Seo M, Ryoo J, Kim M, Choi J, Shin H, et al. Urinary albumin excretion within the normal range predicts the development of diabetes in Korean men. Diabetes Res Clin Pract. 2015;109:427-33 pubmed publisher
    ..b>Cox proportional hazards analysis was used to evaluate the independent hazard ratios (HRs) for diabetes according to ..
  33. Hirata T, Sugiyama D, Nagasawa S, Murakami Y, Saitoh S, Okayama A, et al. A pooled analysis of the association of isolated low levels of high-density lipoprotein cholesterol with cardiovascular mortality in Japan. Eur J Epidemiol. 2017;32:547-557 pubmed publisher
    ..Cohort-stratified Cox proportional hazards models were used to estimate multivariate-adjusted hazard ratios (HRs) for death due to CHD, ..
  34. Seiler R, Ashab H, Erho N, van Rhijn B, Winters B, Douglas J, et al. Impact of Molecular Subtypes in Muscle-invasive Bladder Cancer on Predicting Response and Survival after Neoadjuvant Chemotherapy. Eur Urol. 2017;72:544-554 pubmed publisher
    ..The effect of GSC on survival was estimated by Cox proportional hazard regression models...
  35. Stewart D, Batist G, Kantarjian H, Bradford J, Schiller J, Kurzrock R. The Urgent Need for Clinical Research Reform to Permit Faster, Less Expensive Access to New Therapies for Lethal Diseases. Clin Cancer Res. 2015;21:4561-8 pubmed publisher
    ..of the patient, permit investigators latitude in deviating from protocols, without requiring approved amendments; (viii) confirm the value of predictive biomarkers before requiring the high costs of IDE/CLIA compliance; and (ix) ..
  36. Greenway S, Butts R, Naftel D, Pruitt E, Kirklin J, Larsen I, et al. Statin therapy is not associated with improved outcomes after heart transplantation in children and adolescents. J Heart Lung Transplant. 2016;35:457-65 pubmed publisher
    ..The effects of statins beyond the first year were estimated by Kaplan-Meier and Cox regression multivariable analysis for freedom from PTLD, rejection requiring treatment, any severity of CAV, and ..
  37. Nassif M, Larue S, Raymer D, Novak E, Vader J, Ewald G, et al. Relationship Between Anticoagulation Intensity and Thrombotic or Bleeding Outcomes Among Outpatients With Continuous-Flow Left Ventricular Assist Devices. Circ Heart Fail. 2016;9: pubmed publisher
    ..analyses, we adjusted for age, sex, atrial fibrillation, coronary disease, and LVAD type as time-dependent Cox proportional hazard models. During a mean follow-up of 17.6±13...
  38. Tsung Y, Chung C, Wan H, Chang Y, Shih P, Hsu H, et al. Dimethyl Sulfoxide Attenuates Acute Lung Injury Induced by Hemorrhagic Shock/Resuscitation in Rats. Inflammation. 2017;40:555-565 pubmed publisher
    ..malondialdehyde, nuclear factor-kappa B (NF-?B), inducible nitric oxide synthase (iNOS), and cyclooxygenase 2 (COX-2) confirmed that HS/RES induced pulmonary inflammation and oxidative stress...
  39. Buntenkötter K, Osmers M, Schenk I, Schanzer W, Machnik M, Düe M, et al. Pharmacokinetics and in vitro efficacy of salicylic acid after oral administration of acetylsalicylic acid in horses. BMC Vet Res. 2017;13:28 pubmed publisher
    ..For ASA, IC50 were 0.50 ?g/mL (COX-1) and 5.14 ?g/mL (COX-2)...
  40. Helton J, Boutwell B, DiBernardo M. The relative safety of paternal, maternal, and traditional foster care placements. Child Abuse Negl. 2017;70:1-10 pubmed publisher
    ..Kaplan-Meier and multivariate Cox regression were used to examine the difference in time to the first new investigation by type of out-of-home ..
  41. Matharu G, Hunt L, Murray D, Howard P, Pandit H, Blom A, et al. Is the rate of revision of 36 mm metal-on-metal total hip arthroplasties with Pinnacle acetabular components related to the year of the initial operation? an interrupted time-series analysis using data from the National Joint Registry for England and. Bone Joint J. 2018;100-B:33-41 pubmed publisher
    ..The effect of the year of the primary operation on all-cause rates of revision was assessed using Cox regression and interrupted time-series analysis...
  42. Sapir Pichhadze R, Tinckam K, Laupacis A, Logan A, Beyene J, Kim S. Immune Sensitization and Mortality in Wait-Listed Kidney Transplant Candidates. J Am Soc Nephrol. 2016;27:570-8 pubmed publisher
    ..Relationships between time-varying PRAs and all-cause or cardiovascular mortality were assessed using Cox proportional hazards models...
  43. Hoogwerf B, Lincoff A, Rodriguez A, Chen L, Qu Y. Major adverse cardiovascular events with basal insulin peglispro versus comparator insulins in patients with type 1 or type 2 diabetes: a meta-analysis. Cardiovasc Diabetol. 2016;15:78 pubmed publisher
    ..b>Cox regression analysis was used to compare treatment groups...
  44. Chen X, Chen X, Wang Y, He D, Lu Z, Liu K, et al. Clinical significance of putative markers of cancer stem cells in gastric cancer: A retrospective cohort study. Oncotarget. 2016;7:62049-62069 pubmed publisher
    ..05). Cox regression showed that Oct4-EpCAM was an independently prognostic factor, indicating that double low expression of ..
  45. Dunlap R, Wu S, Wilmer E, Cho E, Li W, Lajevardi N, et al. Pigmentation Traits, Sun Exposure, and Risk of Incident Vitiligo in Women. J Invest Dermatol. 2017;137:1234-1239 pubmed publisher
    ..We used Cox proportional hazards regression models to estimate the multivariate-adjusted hazard ratios and 95% confidence ..
  46. Sun Y, Liu X, Ouyang W, Feng H, Wu J, Chen P, et al. Lymph node characteristics for predicting locoregional recurrence of papillary thyroid cancer in adolescents and young adults. Oral Oncol. 2017;66:22-27 pubmed publisher
    ..08%) experienced LRR. No patients had distant metastases, and no patients died during follow-up. Based on Cox regression analysis, the presence of extranodal extension and more than six metastatic LNs at presentation were ..
  47. Wongchenko M, McArthur G, Dreno B, Larkin J, Ascierto P, Sosman J, et al. Gene Expression Profiling in BRAF-Mutated Melanoma Reveals Patient Subgroups with Poor Outcomes to Vemurafenib That May Be Overcome by Cobimetinib Plus Vemurafenib. Clin Cancer Res. 2017;23:5238-5245 pubmed publisher
    ..Genes significantly associated with PFS (P < 0.05) were identified by univariate Cox proportional hazards modeling, then subjected to unsupervised hierarchical clustering, principal component analysis,..
  48. Wu H, Zhang J. Decreased expression of TFAP2B in endometrial cancer predicts poor prognosis: A study based on TCGA data. Gynecol Oncol. 2018;149:592-597 pubmed publisher
    ..Clinicopathologic characteristics associated with overall survival in TCGA patients using Cox regression and the Kaplan-Meier method. Gene Set Enrichment Analysis (GSEA) was performed using TCGA data set...
  49. Zhang X, Qiu S, Luo P, Zhou H, Jing W, Liang C, et al. Down-regulation of hsa_circ_0001649 in hepatocellular carcinoma predicts a poor prognosis. Cancer Biomark. 2018;22:135-142 pubmed publisher
    ..Kaplan-Meier curve and Cox regression were used to analyze its prognostic significance for HCC patients...
  50. Cho J, Tremmel L, Rho O, Camelio A, Siegel D, Slaga T, et al. Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Oncotarget. 2015;6:39292-306 pubmed publisher
    ..The greater ability of 3-epiCA and MA to inhibit skin tumor promotion was associated with greater reduction of Cox-2 and Twist1 proteins and inhibition of activation (i.e., phosphorylation) of IGF-1R, STAT3 and Src...
  51. Zargar Shoshtari K, Spiess P, Berglund A, Sharma P, Powsang J, Giuliano A, et al. Clinical Significance of p53 and p16(ink4a) Status in a Contemporary North American Penile Carcinoma Cohort. Clin Genitourin Cancer. 2016;14:346-51 pubmed publisher
    ..27 months; P = .27) and median CSS was not reached (P = .16). In a multivariable Cox proportional hazard model, when controlling for pathological nodal status and adjuvant chemotherapy, p16 status was ..
  52. Dabrowska Zamojcin E, Romanowski M, Dziedziejko V, Maciejewska Karlowska A, Sawczuk M, Safranow K, et al. CCL2 gene polymorphism is associated with post-transplant diabetes mellitus. Int Immunopharmacol. 2016;32:62-65 pubmed publisher
    ..An additive model of univariate Cox regression analysis showed that the hazard of PTDM development was significantly positively associated with the ..
  53. Wang Y, Tang A, Chang D, Lu C, Zhang S, Ju S. Long-Term Adverse Effects of Low-Osmolar Compared With Iso-Osmolar Contrast Media After Coronary Angiography. Am J Cardiol. 2016;118:985-90 pubmed publisher
    ..28, 95% CI 0.23 to 0.34). After multivariate Cox regression or IPW, all-cause mortality became comparable and lost statistical significance...
  54. Blute M, Shiau J, Truong M, Shi F, Abel E, Downs T, et al. A biopsy-integrated algorithm for determining Gleason 6 upgrading risk stratifies risk of active surveillance failure in prostate cancer. World J Urol. 2017;35:729-735 pubmed publisher
    ..Univariate and multivariate Cox proportional-hazards regression models, upgrading risk score, and other clinicopathologic features were each ..
  55. Cao G, Sun X, Wu F, Chen W, Li J, Hu W. Low expression of miR-409-3p is a prognostic marker for breast cancer. Eur Rev Med Pharmacol Sci. 2016;20:3825-3829 pubmed
    ..Overall survival (OS) was estimated using the Kaplan-Meier method. The univariable and the multivariable Cox regression analyses were used to evaluate independent prognostic factors...
  56. Takeuchi K, Takeeda M, Amagase K, Nakashima M. Regulatory mechanism of the gastric hyperemic response following barrier disruption: roles of cyclooxygenase-1, the prostaglandin E2/EP1 receptor and sensory neurons. Curr Pharm Des. 2015;21:3002-11 pubmed
    ..mechanism underlying the gastric hyperemic response following barrier disruption, with a focus on cyclooxygenase (COX) isozymes, prostaglandin (PG) E2, and capsaicin-sensitive afferent neurons...
  57. Song S, Kim K, Chie E, Kim S, Park H, Yi N, et al. Locoregional recurrence after curative intent resection for intrahepatic cholangiocarcinoma: implications for adjuvant radiotherapy. Clin Transl Oncol. 2015;17:825-9 pubmed publisher
    ..recurrence rates were analyzed using Kaplan-Meier methods, and the prognostic factors were analyzed using Cox proportional hazards model. Median follow-up duration of surviving patients was 61 months (range 8-139)...
  58. Kaplan K, Lewis J, Gebrian B, Theall K. Soccer and sexual health education: a promising approach for reducing adolescent births in Haiti. Rev Panam Salud Publica. 2015;37:316-23 pubmed
    ..Hazard ratios (HRs) of birth rates were estimated using Cox regression analysis of childbearing data for the three different groups...
  59. Fischer M, Hsu J, Lora C, Ricardo A, Anderson A, BAZZANO L, et al. CKD Progression and Mortality among Hispanics and Non-Hispanics. J Am Soc Nephrol. 2016;27:3488-3497 pubmed
    ..of participants enrolled into the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC Studies, we used Cox proportional hazards models to determine the association between race/ethnicity, CKD progression (50% eGFR loss or ..
  60. Choe J, Park J, Lee S, Kim Y, Jeoung D. Opposing roles of TGF-? in prostaglandin production by human follicular dendritic cell-like cells. Mol Immunol. 2016;76:41-8 pubmed publisher
    ..The present study was aimed at determining the role of TGF-? in IL-1?-induced cyclooxygenase-2 (COX-2) expression by immunoblotting. COX-2 is the key enzyme responsible for PG production in HK cells...
  61. Yang Z, Concannon J, Ng K, Seyb K, Mortensen L, Ranganath S, et al. Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulation. Sci Rep. 2016;6:30263 pubmed publisher
    ..Tetrandrine increased MSC PGE2 secretion through the NF-κB/COX-2 signaling pathway. When co-cultured with mouse macrophages (RAW264...
  62. Donnellan E, Masri A, Johnston D, Pettersson G, Rodriguez L, Popovic Z, et al. Long-Term Outcomes of Patients With Mediastinal Radiation-Associated Severe Aortic Stenosis and Subsequent Surgical Aortic Valve Replacement: A Matched Cohort Study. J Am Heart Assoc. 2017;6: pubmed publisher
    ..001). On multivariable Cox survival analysis, in the whole cohort, higher Society of Thoracic Surgeons score (hazard ratio, 1.14; 95% CI, 1...
  63. Liu J, Ben Q, Lu E, He X, Yang X, Ma J, et al. Long noncoding RNA PANDAR blocks CDKN1A gene transcription by competitive interaction with p53 protein in gastric cancer. Cell Death Dis. 2018;9:168 pubmed publisher
    ..A Kaplan-Meier survival analysis and univariate and multivariate Cox proportional hazards models were performed to evaluate the clinical and prognostic significance of PANDAR (promoter ..
  64. Carlson N, Bellamkonda S, Schmidt L, Redd J, Huecksteadt T, Weber L, et al. The role of the prostaglandin E2 receptors in vulnerability of oligodendrocyte precursor cells to death. J Neuroinflammation. 2015;12:101 pubmed publisher
    Activity of cyclooxygenase 2 (COX-2) in mouse oligodendrocyte precursor cells (OPCs) modulates vulnerability to excitotoxic challenge. The mechanism by which COX-2 renders OPCs more sensitive to excitotoxicity is not known...
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  66. Windham B, Griswold M, Lirette S, KUCHARSKA NEWTON A, Foraker R, Rosamond W, et al. Effects of Age and Functional Status on the Relationship of Systolic Blood Pressure With Mortality in Mid and Late Life: The ARIC Study. J Gerontol A Biol Sci Med Sci. 2017;72:89-94 pubmed
    ..Mortality risk associated with SBP was estimated using adjusted Cox proportional hazard models with a triple interaction between age, functional status, and SBP. Mean follow-up was 12...
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    ..2-16.8 years, and at the start of primary prophylaxis it was 0.8-2.4 years. Factor VIII concentrates (25-40 units kg(-1) dose(-1)) were administered 3 times/week or every other day, according to the ..
  68. Avgerinos E, Chaer R, Naddaf A, El Shazly O, Marone L, Makaroun M. Primary closure after carotid endarterectomy is not inferior to other closure techniques. J Vasc Surg. 2016;64:678-683.e1 pubmed publisher
    ..1; P = .003) as predictors of perioperative stroke and death, but not the type of closure. Cox regression analysis demonstrated, among other risk factors, no statin use (hazard ratio, 2.1; P = ...
  69. Jing S, Lu Y, Yang J, Deng W, Zhou Q, Jiao B. Expression of long non-coding RNA CRNDE in glioma and its correlation with tumor progression and patient survival. Eur Rev Med Pharmacol Sci. 2016;20:3992-3996 pubmed
    ..001). The multivariate Cox regression analysis indicated that CRNDE expression was an independent prognostic factor for overall survival...
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  71. Kullander S, Rahman M, Norén M, Mollah A. Devario in Bangladesh: Species diversity, sibling species, and introgression within danionin cyprinids (Teleostei: Cyprinidae: Danioninae). PLoS ONE. 2017;12:e0186895 pubmed publisher
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  72. Deroo L, Skjærven R, Wilcox A, Klungsøyr K, Wikström A, Morken N, et al. Placental abruption and long-term maternal cardiovascular disease mortality: a population-based registry study in Norway and Sweden. Eur J Epidemiol. 2016;31:501-11 pubmed publisher
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  73. Niedzwiecki P, Pilacinski S, Uruska A, Adamska A, Naskret D, Zozulinska Ziolkiewicz D. Influence of remission and its duration on development of early microvascular complications in young adults with type 1 diabetes. J Diabetes Complications. 2015;29:1105-11 pubmed publisher
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  74. Klement R, Allgäuer M, Andratschke N, Blanck O, Boda Heggemann J, Dieckmann K, et al. Bayesian Cure Rate Modeling of Local Tumor Control: Evaluation in Stereotactic Body Radiation Therapy for Pulmonary Metastases. Int J Radiat Oncol Biol Phys. 2016;94:841-9 pubmed publisher
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  75. Takahashi N, Yamamoto T, Matsushita H, Sugawara T, Kubozono M, Umezawa R, et al. Metabolic tumor volume on FDG-PET/CT is a possible prognostic factor for Stage I lung cancer patients treated with stereotactic body radiation therapy: a retrospective clinical study. J Radiat Res. 2016;57:655-661 pubmed
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  76. Juvani A, Oksanen T, Virtanen M, Elovainio M, Salo P, Pentti J, et al. Organizational justice and disability pension from all-causes, depression and musculoskeletal diseases: A Finnish cohort study of public sector employees. Scand J Work Environ Health. 2016;42:395-404 pubmed publisher
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  77. Feng L, Ransom C, Nazzal M, Allen T, Li Y, Truong T, et al. The Role of Progesterone and a Novel Progesterone Receptor, Progesterone Receptor Membrane Component 1, in the Inflammatory Response of Fetal Membranes to Ureaplasma parvum Infection. PLoS ONE. 2016;11:e0168102 pubmed publisher
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  78. Acs B, Zámbó V, Vizkeleti L, Szász A, Madaras L, Szentmártoni G, et al. Ki-67 as a controversial predictive and prognostic marker in breast cancer patients treated with neoadjuvant chemotherapy. Diagn Pathol. 2017;12:20 pubmed publisher
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  79. Gutierrez J, Elkind M, Dong C, Di Tullio M, Rundek T, Sacco R, et al. Brain Perivascular Spaces as Biomarkers of Vascular Risk: Results from the Northern Manhattan Study. AJNR Am J Neuroradiol. 2017;38:862-867 pubmed publisher
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  80. Czekaj R, Majka J, Magierowska K, Sliwowski Z, Magierowski M, Pajdo R, et al. Mechanisms of curcumin-induced gastroprotection against ethanol-induced gastric mucosal lesions. J Gastroenterol. 2018;53:618-630 pubmed publisher
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  84. Zschaeck S, Löck S, Leger S, Haase R, Bandurska Luque A, Appold S, et al. FDG uptake in normal tissues assessed by PET during treatment has prognostic value for treatment results in head and neck squamous cell carcinomas undergoing radiochemotherapy. Radiother Oncol. 2017;122:437-444 pubmed publisher
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  85. Deng W, Tan X, Zhou Q, Ai Z, Liu W, Chen W, et al. Gender-related differences in clinicopathological characteristics and renal outcomes of Chinese patients with IgA nephropathy. BMC Nephrol. 2018;19:31 pubmed publisher
    ..73 m2, dialysis, or renal transplantation). The prognostic effects of gender were evaluated by Cox regression models. A total of 988 eligible IgAN patients were enrolled, and the ratio of males to females was 1:1.4...
  86. Lildal S, Nørregaard R, Andreassen K, Christiansen F, Jung H, Pedersen M, et al. Ureteral Access Sheath Influence on the Ureteral Wall Evaluated by Cyclooxygenase-2 and Tumor Necrosis Factor-? in a Porcine Model. J Endourol. 2017;31:307-313 pubmed publisher
    To examine the effect of ureteral access sheath (UAS) on the expression of the pro-inflammatory mediators cyclooxygenase-2 (COX-2) and tumor necrosis factor-? (TNF-?) in the ureteral wall.
  87. Chae H, Song W, Ahn J, Li Q, Lee B, Kweon K, et al. Immunomodulatory effects of soluble factors secreted by feline adipose tissue-derived mesenchymal stem cells. Vet Immunol Immunopathol. 2017;191:22-29 pubmed publisher
    ..The mRNA expression of immunomodulatory factors from fATMSCs, including cyclooxygenase-2 (COX-2), transforming growth factor (TGF)-?, indoleamine-2,3-dioxygenase (IDO) and hepatocyte growth factor, increased ..
  88. Xu B, Deng H, Zhang X, Luo J, Zhang G, Zhang Z, et al. A novel Danshensu/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and exerts cardioprotection in dogs. Eur J Pharmacol. 2018;818:158-166 pubmed publisher
    ..In addition, cyclooxygenase (COX), muscarine receptor and ?-adrenoceptor were not involved in ADTM-induced vasorelaxation...
  89. Liu J, Duan S, Chen P, Cai G, Wang Y, Tang L, et al. Development and validation of a prognostic nomogram for IgA nephropathy. Oncotarget. 2017;8:94371-94381 pubmed publisher
    ..A nomogram was developed using COX regression coefficients to predict decline of estimate Glomerular filtration rate (eGFR) ? 50% and end-stage renal ..
  90. Brito B, Mohapatra J, Subramaniam S, Pattnaik B, Rodriguez L, Moore B, et al. Dynamics of widespread foot-and-mouth disease virus serotypes A, O and Asia-1 in southern Asia: A Bayesian phylogenetic perspective. Transbound Emerg Dis. 2017;: pubmed publisher
    ..1990 [1988-1991] for A/G-18 (G-VII); 2003 [2000-2006] for Asia-1 Sindh08 and 2002 [1999-2004] for Asia-1 G-VIII. We estimated the mean of the overall substitution rate of the VP1 coding region (substitution/site/year) for ..
  91. Slade M, DiPersio J, Westervelt P, Vij R, Schroeder M, Romee R. Haploidentical Hematopoietic Cell Transplant with Post-Transplant Cyclophosphamide and Peripheral Blood Stem Cell Grafts in Older Adults with Acute Myeloid Leukemia or Myelodysplastic Syndrome. Biol Blood Marrow Transplant. 2017;23:1736-1743 pubmed publisher
    ..Overall survival (OS) was analyzed using 3 different Cox proportional hazards models. We identified 112 haplo-HCT patients, 95 with AML and 17 with MDS...
  92. Teeter A, Griffin K, Howard L, Aronson W, Terris M, Kane C, et al. Does Early Prostate Specific Antigen Doubling Time after Radical Prostatectomy, Calculated Prior to Prostate Specific Antigen Recurrence, Correlate with Prostate Cancer Outcomes? A Report from the SEARCH Database Group. J Urol. 2017;: pubmed publisher
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