CYP7A1

Summary

Gene Symbol: CYP7A1
Description: cytochrome P450 family 7 subfamily A member 1
Alias: CP7A, CYP7, CYPVII, cholesterol 7-alpha-monooxygenase, cholesterol 7-alpha-hydroxylase, cytochrome P450 7A1, cytochrome P450, family 7, subfamily A, polypeptide 1, cytochrome P450, subfamily VIIA polypeptide 1
Species: human
Products:     CYP7A1

Top Publications

  1. Zhou B, Zhang S, Xiao C, Zhang K, Zhang L, Li G, et al. [Association of 7alpha-hydroxylase gene polymorphism with levels of plasma lipids]. Yi Chuan. 2004;26:283-6 pubmed
    To study the distribution of Eco31I restriction polymorphism in nucleotide -204 of 7alpha-hydroxylase gene(CYP7A1)in Sichuan Han population of China and association of the polymorphism with coronary heart disease(CHD),CYP7A1 genotyping ..
  2. Cohen J, Cali J, Jelinek D, Mehrabian M, Sparkes R, Lusis A, et al. Cloning of the human cholesterol 7 alpha-hydroxylase gene (CYP7) and localization to chromosome 8q11-q12. Genomics. 1992;14:153-61 pubmed
    ..paper, we describe the cloning, characterization, and chromosomal mapping of the human 7 alpha-hydroxylase gene (CYP7). The gene spans 10 kb and contains six exons and five introns...
  3. Hofman M, Princen H, Zwinderman A, Jukema J. Genetic variation in the rate-limiting enzyme in cholesterol catabolism (cholesterol 7alpha-hydroxylase) influences the progression of atherosclerosis and risk of new clinical events. Clin Sci (Lond). 2005;108:539-45 pubmed
    ..The rate-limiting enzyme in the catabolism of cholesterol into bile acids is CYP7A1 (cholesterol 7alpha-hydroxylase)...
  4. Qin J, Gao D, Jiang Q, Zhou Q, Kong Y, Wang Y, et al. Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene. Mol Endocrinol. 2004;18:2424-39 pubmed
    Cholesterol 7-alpha-hydroxylase (CYP7A1) catalyzes a rate-limiting step in bile acid synthesis in liver, and its gene transcription is under complex regulation by multiple nuclear receptors in response to bile acids, cholesterol ..
  5. Jiang Z, Han T, Suo G, Feng D, Chen S, Cai X, et al. Polymorphisms at cholesterol 7alpha-hydroxylase, apolipoproteins B and E and low density lipoprotein receptor genes in patients with gallbladder stone disease. World J Gastroenterol. 2004;10:1508-12 pubmed
    ..Multiple-variable logistic regression model analysis showed that besides BMI, GSD was affected by polygenetic factors. But the mechanism for these two alleles responsible for GSD requires further investigations. ..
  6. Tiemann M, Han Z, Soccio R, Bollineni J, Shefer S, Sehayek E, et al. Cholesterol feeding of mice expressing cholesterol 7alpha-hydroxylase increases bile acid pool size despite decreased enzyme activity. Proc Natl Acad Sci U S A. 2004;101:1846-51 pubmed
    Dietary cholesterol regulation of cholesterol 7alpha-hydroxylase (Cyp7a1), the rate-limiting enzyme in the classical pathway of bile acid synthesis, has been implicated in plasma cholesterol responsiveness...
  7. Nakamoto K, Wang S, Jenison R, Guo G, Klaassen C, Wan Y, et al. Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene. BMC Genet. 2006;7:29 pubmed
    Cholesterol 7-alpha-hydroxylase (CYP7A1) is the rate limiting enzyme for converting cholesterol into bile acids...
  8. Juzyszyn Z, Kurzawski M, Lener A, Modrzejewski A, Pawlik A, Drozdzik M. Cholesterol 7alpha-hydrolase (CYP7A1) c.-278A>C promoter polymorphism in gallstone disease patients. Genet Test. 2008;12:97-100 pubmed publisher
    There is growing evidence that gallstone formation may be genetically determined. Cholesterol 7alpha-hydrolase (CYP7A1) is an enzyme that catalyzes the first, rate-limiting reaction of cholesterol catabolic pathway. Recently, a common c...
  9. Hubacek J, Pitha J, Skodova Z, Poledne R, Lanska V, Waterworth D, et al. Polymorphisms in CYP-7A1, not APOE, influence the change in plasma lipids in response to population dietary change in an 8 year follow-up; results from the Czech MONICA study. Clin Biochem. 2003;36:263-7 pubmed
    ..38 (+/- 0.20) mmol/L, AC -0.65 +/- (0.08), CC -1.33 (+/- 0.3) mmol/L, p = 0.01] over the 8 yr time period. Variation in the CYP-7A1 gene may play an important role in an individual's sensitivity to dietary composition. ..

More Information

Publications89

  1. Kovar J, Lenicek M, Zimolová M, Vitek L, Jirsa M, Pitha J. Regulation of diurnal variation of cholesterol 7alpha-hydroxylase (CYP7A1) activity in healthy subjects. Physiol Res. 2010;59:233-8 pubmed
    Cholesterol 7alpha-hydroxylase (CYP7A1), the key regulatory enzyme of bile acid synthesis, displays a pronounced diurnal variation...
  2. Pullinger C, Eng C, Salen G, Shefer S, Batta A, Erickson S, et al. Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype. J Clin Invest. 2002;110:109-17 pubmed
    Bile acid synthesis plays a critical role in the maintenance of mammalian cholesterol homeostasis. The CYP7A1 gene encodes the enzyme cholesterol 7alpha-hydroxylase, which catalyzes the initial step in cholesterol catabolism and bile acid ..
  3. Sánchez Cuén J, Aguilar Medina M, Arámbula Meraz E, Romero Navarro J, Granados J, Sicairos Medina L, et al. ApoB-100, ApoE and CYP7A1 gene polymorphisms in Mexican patients with cholesterol gallstone disease. World J Gastroenterol. 2010;16:4685-90 pubmed
    To determine the possible association of the ApoB-100 (XbaI), ApoE (HhaI) and CYP7A1 (BsaI) gene polymorphisms, with the development of cholesterol gallstone disease (GD) in a Mexican population...
  4. Nitta M, Ku S, Brown C, Okamoto A, Shan B. CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene. Proc Natl Acad Sci U S A. 1999;96:6660-5 pubmed
    ..Cotransfection of a CPF expression plasmid and a CYP7A reporter gene resulted in specific induction of CYP7A-directed transcription. These observations suggest that CPF is a key regulator of human CYP7A gene expression in the liver. ..
  5. Fu L, Zhao Y, Wu X, Liu H, Shi J, Lu J, et al. CYP7A1 genotypes and haplotypes associated with hypertension in an obese Han Chinese population. Hypertens Res. 2011;34:722-7 pubmed publisher
    ..investigated the association between single-nucleotide polymorphisms (SNPs; rs3808607 and rs1125226) within the CYP7A1 promoter and hypertension susceptibility in a Han Chinese population...
  6. Noshiro M, Okuda K. Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7 alpha-hydroxylase. FEBS Lett. 1990;268:137-40 pubmed
    ..The deduced amino acid sequence showed 82% similarity to rat P-450ch7 alpha. Unique amino acid residues were observed in putative binding domains for heme and steroid which are highly conserved in most steroidogenic P-450s. ..
  7. Poduri A, Khullar M, Bahl A, Sharma Y, Talwar K. A combination of proatherogenic single-nucleotide polymorphisms is associated with increased risk of coronary artery disease and myocardial infarction in Asian Indians. DNA Cell Biol. 2009;28:451-60 pubmed publisher
    ..Fifteen SNPs of CETP, ABCB1, APOAI, CYP7A1, and HMGCR genes were genotyped in 265 CAD patients and 150 controls of North Indian origin...
  8. Lambrinoudaki I, Kaparos G, Vlachou S, Stamatelopoulos K, Georgiopoulos G, Sergentanis T, et al. CYP A-204C polymorphism is associated with subclinical atherosclerosis in postmenopausal women. Menopause. 2008;15:1163-8 pubmed publisher
    ..It remains to be clarified whether the presence of these polymorphisms may be valuable in assessing the inherent risk among postmenopausal women. ..
  9. Kim H, Park H, Kim E, Lee K, Kim K, Choi B, et al. Common CYP7A1 promoter polymorphism associated with risk of neuromyelitis optica. Neurobiol Dis. 2010;37:349-55 pubmed publisher
    ..Statistical analyses revealed that a common promoter SNP in CYP7A1 has a protective/gene dose-dependent effect on the risk of NMO (P=0.0004)...
  10. Molowa D, Chen W, Cimis G, Tan C. Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene. Biochemistry. 1992;31:2539-44 pubmed
    As an initial step toward understanding the transcriptional regulation of cholesterol 7 alpha-hydroxylase (CYP7) in man, we isolated and functionally characterized the 5'-flanking region of the human CYP7 gene...
  11. Qiao Y, Liu R, Bai H, Liu Y, Li X, Tang C, et al. [Association between cholesterol 7alpha-hydroxylase -204A/C gene polymorphism and endogenous hypertriglyceridemia in Chinese]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007;24:432-6 pubmed
    ..05). These results suggest that -204A/C polymorphism in the CYP7A1 gene does not relate with HTG but may has an effect on serum triglyceride and apoCIII levels in patients with ..
  12. De Castro Orós I, Pampín S, Cofan M, Mozas P, Pintó X, Salas Salvado J, et al. Promoter variant -204A > C of the cholesterol 7?-hydroxylase gene: association with response to plant sterols in humans and increased transcriptional activity in transfected HepG2 cells. Clin Nutr. 2011;30:239-46 pubmed publisher
    ..Plasma lipid variation relates to promoter variant -204A > C (rs3808607) of the CYP7A1 gene encoding for 7?-hydroxylase, an enzyme for bile acid synthesis...
  13. Abrahamsson A, Krapivner S, Gustafsson U, Muhrbeck O, Eggertsen G, Johansson I, et al. Common polymorphisms in the CYP7A1 gene do not contribute to variation in rates of bile acid synthesis and plasma LDL cholesterol concentration. Atherosclerosis. 2005;182:37-45 pubmed
    ..It is concluded that common polymorphisms of the CYP7A1 gene do not contribute to variation in cholesterol 7alpha-hydroxylase activity, rates of bile acid synthesis and ..
  14. Kajinami K, Brousseau M, Ordovas J, Schaefer E. A promoter polymorphism in cholesterol 7alpha-hydroxylase interacts with apolipoprotein E genotype in the LDL-lowering response to atorvastatin. Atherosclerosis. 2005;180:407-15 pubmed
    ..This suggests that variation in the cholesterol 7alpha-hydroxylase gene (CYP7A1), a key enzyme in bile-acid biosynthesis, may influence the statin response...
  15. Srivastava A, Choudhuri G, Mittal B. CYP7A1 (-204 A>C; rs3808607 and -469 T>C; rs3824260) promoter polymorphisms and risk of gallbladder cancer in North Indian population. Metabolism. 2010;59:767-73 pubmed publisher
    Cholesterol 7-alpha hydroxylase (CYP7A1), which is a rate-limiting enzyme for cholesterol catabolism and bile acid synthesis, may affect cholesterol homeostasis and result in gallstone formation that is a major risk factor for gallbladder ..
  16. Hofman M, Weggemans R, Zock P, Schouten E, Katan M, Princen H. CYP7A1 A-278C polymorphism affects the response of plasma lipids after dietary cholesterol or cafestol interventions in humans. J Nutr. 2004;134:2200-4 pubmed
    ..The rate-limiting enzyme in the conversion of cholesterol into bile acids is cholesterol 7alpha-hydroxylase (CYP7A1)...
  17. Hofman M, Groenendijk M, Verkuijlen P, Jonkers I, Mohrschladt M, Smelt A, et al. Modulating effect of the A-278C promoter polymorphism in the cholesterol 7alpha-hydroxylase gene on serum lipid levels in normolipidaemic and hypertriglyceridaemic individuals. Eur J Hum Genet. 2004;12:935-41 pubmed
    The rate-limiting enzyme in the conversion of cholesterol into bile acids is cholesterol 7alpha-hydroxylase (CYP7A1)...
  18. Hagiwara T, Kono S, Yin G, Toyomura K, Nagano J, Mizoue T, et al. Genetic polymorphism in cytochrome P450 7A1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study. Cancer Res. 2005;65:2979-82 pubmed
    ..Cholesterol 7alpha-hydroxylase (CYP7A1) is the rate-limiting enzyme in the synthesis of bile acids from cholesterol in the liver, and thus may be an ..
  19. Hegele R, Wang J, Harris S, Brunt J, Young T, Hanley A, et al. Variable association between genetic variation in the CYP7 gene promoter and plasma lipoproteins in three Canadian populations. Atherosclerosis. 2001;154:579-87 pubmed
    The promoter sequence variant -278A in the CYP7 gene, which encodes cholesterol 7-alpha hydroxylase, was previously reported to be associated with reduced plasma low density lipoprotein (LDL) cholesterol concentration...
  20. Schwarz M, Lund E, Russell D. Two 7 alpha-hydroxylase enzymes in bile acid biosynthesis. Curr Opin Lipidol. 1998;9:113-8 pubmed
    ..cDNAs encoding these proteins have been isolated and used to define two evolutionarily conserved pathways that produce 7 alpha-hydroxylated bile acids. ..
  21. Goodwin B, Watson M, Kim H, Miao J, Kemper J, Kliewer S. Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha. Mol Endocrinol. 2003;17:386-94 pubmed
    In rodent liver, transcription of the gene encoding cholesterol 7alpha-hydroxylase (CYP7A1), which catalyzes the rate-limiting step in the classic bile acid synthetic pathway, is stimulated by the liver X receptor alpha (LXRalpha), a ..
  22. Holt J, Luo G, Billin A, Bisi J, McNeill Y, Kozarsky K, et al. Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes Dev. 2003;17:1581-91 pubmed
    ..proposed to play a central role in the feedback repression of the gene encoding cholesterol 7 alpha-hydroxylase (CYP7A1), the first and rate-limiting step in the biosynthesis of bile acids...
  23. Davis R, Miyake J, Hui T, Spann N. Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHP. J Lipid Res. 2002;43:533-43 pubmed
    Cholesterol-7alpha-hydroxylase (CYP7A1) regulates the pathway through which cholesterol is converted into bile acids...
  24. Miura T, Tachikawa M, Ohtsuka H, Fukase K, Nakayama S, Sakata N, et al. Application of Quantitative Targeted Absolute Proteomics to Profile Protein Expression Changes of Hepatic Transporters and Metabolizing Enzymes During Cholic Acid-Promoted Liver Regeneration. J Pharm Sci. 2017;106:2499-2508 pubmed publisher
    ..polypeptide, anion transporting polypeptide (oatp) 1a1, and oatp1b2, bile acid synthesis-related enzymes cyp7a1 and cyp8b1, and drug transporters breast cancer resistance protein, multidrug resistance-associated protein 6, ..
  25. Del Bas J, Crescenti A, Arola Arnal A, Oms Oliu G, Arola L, Caimari A. Intake of grape procyanidins during gestation and lactation impairs reverse cholesterol transport and increases atherogenic risk indexes in adult offspring. J Nutr Biochem. 2015;26:1670-7 pubmed publisher
    ..with the observed mRNA down-regulation of the rate-limiting enzyme in the hepatic bile acid synthesis pathway Cyp7A1. Conversely, GSPE programming also resulted in up-regulated gene expression of different key components of the RCT ..
  26. Wang H, Zhao Z, Zhou J, Guo Y, Wang G, Hao H, et al. A novel intestinal-restricted FXR agonist. Bioorg Med Chem Lett. 2017;27:3386-3390 pubmed publisher
    ..Fex-3 could selectively activate intestinal FXR and promote the expression of BSEP and SHP while suppressing CYP7A1 which is involved in bile acids syntheses better than the reported intestinal-restricted FXR agonist fexaramine (..
  27. Chow E, Quach H, Zhang Y, Wang J, Evans D, Li A, et al. Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models. J Pharmacol Exp Ther. 2017;360:174-191 pubmed
    ..Proteomics revealed persistence of remnant murine proteins (cyotchrome P450 7?-hydroxylase (Cyp7a1) and other enzymes and transporters) in hFRGN livers and suggest the likelihood of mouse activity...
  28. Xiao P, Ji H, Ye Y, Zhang B, Chen Y, Tian J, et al. Dietary silymarin supplementation promotes growth performance and improves lipid metabolism and health status in grass carp (Ctenopharyngodon idellus) fed diets with elevated lipid levels. Fish Physiol Biochem. 2017;43:245-263 pubmed publisher
    ..The SM100 groups up-regulated hepatic gene expressions of HMGCR and CYP7A1 compared with the SM0 groups...
  29. He K, Li X, Xiao Y, Yong Y, Zhang Z, Li S, et al. Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice. Food Funct. 2016;7:3505-15 pubmed publisher
    ..regulatory element binding proteins), LDLR (low density lipoprotein receptor), UCP2 (uncoupling protein 2) and CYP7A1 (cholesterol 7α-hydroxylase)...
  30. Chen J, Zhu L, Li X, Zheng H, Yan T, Xie C, et al. High-Throughput and Reliable Isotope Label-free Approach for Profiling 24 Metabolic Enzymes in FVB Mice and Sex Differences. Drug Metab Dispos. 2017;45:624-634 pubmed publisher
    ..Cyp2c29, Cyp1a2, Cyp27a1, Ugt2b1, Ugt2b5 and Ugt2b36 were male predominant, whereas Cyp2c39, Cyp2d22, Cyp7a1, Ugt1a1, Ugt1a5, Sult1a1, Sult3a1, and Sult1d1 were female predominant...
  31. Zhan L, Yang I, Kong B, Shen J, Gorczyca L, Memon N, et al. Dysregulation of bile acid homeostasis in parenteral nutrition mouse model. Am J Physiol Gastrointest Liver Physiol. 2016;310:G93-G102 pubmed publisher
    ..PN increased liver gene expression of Cyp7a1 and markedly decreased that of Cyp8b1, Cyp7b1, Bsep, and Shp...
  32. Kawase A, Yamada A, Gamou Y, Tahara C, Takeshita F, Murata K, et al. Increased effects of ginsenosides on the expression of cholesterol 7?-hydroxylase but not the bile salt export pump are involved in cholesterol metabolism. J Nat Med. 2013;67:545-53 pubmed publisher
    ..In-vivo studies showed the upregulation of CYP7A1 mRNA in hypercholesterolemic rats treated with RGE...
  33. Trenteseaux C, Gaston A, Aguesse A, Poupeau G, de Coppet P, Andriantsitohaina R, et al. Perinatal Hypercholesterolemia Exacerbates Atherosclerosis Lesions in Offspring by Altering Metabolism of Trimethylamine-N-Oxide and Bile Acids. Arterioscler Thromb Vasc Biol. 2017;37:2053-2063 pubmed publisher
    ..At 18 weeks of age, female born to hypercholesterolemic mothers showed lower hepatic Scarb1 and Cyp7a1 but higher Nr1h4 gene expression compared with female born to normocholesterolemic mothers...
  34. Zhao Y, He X, Ma X, Wen J, Li P, Wang J, et al. Paeoniflorin ameliorates cholestasis via regulating hepatic transporters and suppressing inflammation in ANIT-fed rats. Biomed Pharmacother. 2017;89:61-68 pubmed publisher
    ..bile salt export pump (BSEP), multidrug resistance-associated protein 2 (MRP2) and cholesterol 7α-hydroxylase (Cyp7a1) were investigated by western blotting...
  35. Pozzo L, Vornoli A, Coppola I, Croce C, Giorgetti L, Gervasi P, et al. Effect of HFD/STZ on expression of genes involved in lipid, cholesterol and glucose metabolism in rats. Life Sci. 2016;166:149-156 pubmed publisher
    ..HMGCoA red and LDLr), instead the cholesterol catabolism was increased, as shown by the mRNA induction of the CYP7A1 and CYP8B1 (key genes for BA acid)...
  36. Valero Muñoz M, Ballesteros S, Ruiz Roso B, Pérez Olleros L, Martin Fernandez B, Lahera V, et al. Supplementation with an insoluble fiber obtained from carob pod (Ceratonia siliqua L.) rich in polyphenols prevents dyslipidemia in rabbits through SIRT1/PGC-1α pathway. Eur J Nutr. 2019;58:357-366 pubmed publisher
    ..reductase (HMG-CoA reductase) and cytochrome P450, family 7, subfamily a, polypeptide 1C (CYP7A1) (82.34, 114.42%, respectively) as well as protein expression of LDL receptor (42.48%) in DL rabbits...
  37. Koelfat K, Schaap F, Hodin C, Visschers R, Svavarsson B, Lenicek M, et al. Parenteral nutrition dysregulates bile salt homeostasis in a rat model of parenteral nutrition-associated liver disease. Clin Nutr. 2017;36:1403-1410 pubmed publisher
    ..Nonetheless, Cyp7a1 expression was reduced after 7 days of PN, indicative for lowered bile salt synthesis...
  38. Saito T, Nishida M, Saito M, Tanabe A, Eitsuka T, Yuan S, et al. The fruit of Acanthopanax senticosus (Rupr. et Maxim.) Harms improves insulin resistance and hepatic lipid accumulation by modulation of liver adenosine monophosphate-activated protein kinase activity and lipogenic gene expression in high-fat diet-fe. Nutr Res. 2016;36:1090-1097 pubmed publisher
    ..In summary, GF supplementation improved obesity-associated insulin resistance and hepatic lipid accumulation through modulation of AMPK activity and lipid metabolism-associated gene expression. ..
  39. He K, Hu Y, Ma H, Zou Z, Xiao Y, Yang Y, et al. Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways. Biochim Biophys Acta. 2016;1862:1696-709 pubmed publisher
    ..can also be attributed to their action as agonists of FXR and TGR5, activators for SREBP2, LDLR, UCP2 and CYP7A1, inhibitors of HMGCR, TXNIP, TLR4 and JNK...
  40. Tabata S, Yin G, Ogawa S, Yamaguchi K, Mineshita M, Kono S. Genetic polymorphism of cholesterol 7alpha-hydroxylase (CYP7A1) and colorectal adenomas: Self Defense Forces Health Study. Cancer Sci. 2006;97:406-10 pubmed
    ..Cholesterol 7alpha-hydroxylase (CYP7A1) is the rate-limiting enzyme producing bile acids from cholesterol...
  41. Han Z, Heath S, Shmulewitz D, Li W, Auerbach S, Blundell M, et al. Candidate genes involved in cardiovascular risk factors by a family-based association study on the island of Kosrae, Federated States of Micronesia. Am J Med Genet. 2002;110:234-42 pubmed
    ..We further confirmed the connection between the apo AII gene and Tg level by a nonparametric linkage analysis. We therefore conclude that many of these candidate genes may play a significant role in susceptibility to heart disease. ..
  42. Okushin K, Tsutsumi T, Enooku K, Fujinaga H, Kado A, Shibahara J, et al. The intrahepatic expression levels of bile acid transporters are inversely correlated with the histological progression of nonalcoholic fatty liver disease. J Gastroenterol. 2016;51:808-18 pubmed publisher
    ..Such down-regulation may cause excessive BA levels in hepatocytes, leading to cell injury. Our findings may afford new insights into the pathogenesis of NASH. ..
  43. Oda H. Chrononutrition. J Nutr Sci Vitaminol (Tokyo). 2015;61 Suppl:S92-4 pubmed publisher
    ..Well-regulated eating habits normalize the liver clock gene, the rhythm of CYP7A1 gene, and blood cholesterol levels through insulin secretion...
  44. Kang L, Connolly T, Weng N, Jian W. LC-MS/MS quantification of 7?-hydroxy-4-cholesten-3-one (C4) in rat and monkey plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1064:49-55 pubmed publisher
    ..metabolism via cholesterol 7?-hydroxylase, an enzyme also known as cholesterol 7-alpha-monooxygenase or cytochrome P450 7A1 (CYP7A1). C4 is a stable intermediate in the rate limiting pathway of bile acid biosynthesis...
  45. Liu B, Li Y, Ji H, Lu H, Li H, Shi Y. Glutamine attenuates obstructive cholestasis in rats via farnesoid X receptor-mediated regulation of Bsep and Mrp2. Can J Physiol Pharmacol. 2017;95:215-223 pubmed publisher
    ..cotransporting polypeptide (Ntcp) and the bile acid synthesis enzyme cholesterol 7?-hydroxylase (Cyp7a1) expression were observed in rats with BDL treated with Gln in vivo...
  46. Out C, Patankar J, Doktorova M, Boesjes M, Bos T, de Boer S, et al. Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4. J Hepatol. 2015;63:697-704 pubmed publisher
    ..fecal excretion and synthesis of bile acids, but increased the expression of the bile acid synthesis enzyme CYP7A1. Similar effects were seen in germfree mice...
  47. Rong A, Borjihan G, Qiao Y. Effect of GBOT on blood lipid and blood glucose metabolism in rats with atherosclerosis. Genet Mol Res. 2015;14:7801-10 pubmed publisher
  48. Mackay D, Eck P, Gebauer S, Baer D, Jones P. CYP7A1-rs3808607 and APOE isoform associate with LDL cholesterol lowering after plant sterol consumption in a randomized clinical trial. Am J Clin Nutr. 2015;102:951-7 pubmed publisher
    ..Cholesterol 7 alpha-hydroxylase (CYP7A1-rs3808607) T/T homozygotes showed no LDL cholesterol lowering (mean ± SEM: -0.05 ± 0.07 mmol/L, P = 0...
  49. Hu M, Qu X, Pan L, Fu C, Jia P, Liu Q, et al. Effects of toxic Microcystis aeruginosa on the silver carp Hypophthalmichtys molitrix revealed by hepatic RNA-seq and miRNA-seq. Sci Rep. 2017;7:10456 pubmed publisher
    ..qPCR also indicated that Steap4, Cyp7a1, CABZ01088134...
  50. Dash A, Figler R, Blackman B, Marukian S, Collado M, Lawson M, et al. Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017;39:93-103 pubmed publisher
    ..Dose-dependent, transcriptional effects suggested suppression of bile acid synthesis (↓CYP7A1, ↓CYP27A1) and increased bile efflux (↑ABCB4, ↑ABCB11, ↑OSTA, ↑OSTB)...
  51. Xu G, Li H, Pan L, Shang Q, Honda A, Ananthanarayanan M, et al. FXR-mediated down-regulation of CYP7A1 dominates LXRalpha in long-term cholesterol-fed NZW rabbits. J Lipid Res. 2003;44:1956-62 pubmed
    We investigated how cholesterol feeding regulates cholesterol 7alpha-hydroxylase (CYP7A1) via the nuclear receptors farnesoid X receptor (FXR) and liver X receptor alpha (LXRalpha) in New Zealand white rabbits...
  52. Zhao L, Xu J, Shi Z, Englert N, Zhang S. Pregnane X receptor (PXR) deficiency improves high fat diet-induced obesity via induction of fibroblast growth factor 15 (FGF15) expression. Biochem Pharmacol. 2017;142:194-203 pubmed publisher
    ..hepatic triglyceride levels, liver steatosis, and hepatic mRNA expression levels of cholesterol 7?-hydroxylase (CYP7A1) and sterol 12?-hydroxylase (CYP8B1), the key enzymes in the bile acid classical synthesis pathway, were ..
  53. Deng R, Yang D, Radke A, Yang J, Yan B. The hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: dominance of transactivation over farsenoid X receptor-mediated antagonism. J Pharmacol Exp Ther. 2007;320:1153-62 pubmed
    ..of cholesterol to bile acids in the liver is initiated by the rate-limiting enzyme cholesterol 7alpha-hydroxylase (CYP7A1) and excretion of bile acids from the liver is mediated by the bile salt export pump (BSEP)...
  54. Wang Y, Harding S, Eck P, Thandapilly S, Gamel T, Abdel Aal E, et al. High-Molecular-Weight β-Glucan Decreases Serum Cholesterol Differentially Based on the CYP7A1 rs3808607 Polymorphism in Mildly Hypercholesterolemic Adults. J Nutr. 2016;146:720-7 pubmed publisher
    ..polymorphism (SNP) rs3808607-G allele (GG or GT) of the cytochrome P450 family 7 subfamily A member 1 gene (CYP7A1) had greater responses to 3 g HMW β-glucan/d in lowering TC than TT carriers (P= 0.0006)...
  55. Rudling M, Angelin B, Stahle L, Reihner E, Sahlin S, Olivecrona H, et al. Regulation of hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and cholesterol 7alpha-hydroxylase mRNAs in human liver. J Clin Endocrinol Metab. 2002;87:4307-13 pubmed
    ..cholesterol metabolism in human liver, we simultaneously quantified mRNA levels of cholesterol 7alpha-hydroxylase (CYP7A1), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR), and low- density lipoprotein receptors (LDLRs) in liver ..
  56. Moon Y, Park B, Park H. Hypoxic repression of CYP7A1 through a HIF-1α- and SHP-independent mechanism. BMB Rep. 2016;49:173-8 pubmed
    ..We found that hypoxic stress (0.1% O2) decreased the expression of cytochrome P450 7A1 (CYP7A1), a rate-limiting enzyme involved in bile acid biosynthesis...
  57. Iwanicki T, Balcerzyk A, Niemiec P, Nowak T, Ochalska Tyka A, Krauze J, et al. CYP7A1 gene polymorphism located in the 5' upstream region modifies the risk of coronary artery disease. Dis Markers. 2015;2015:185969 pubmed publisher
    7-Alpha cholesterol hydroxylase (CYP7A1), the first enzyme of classic conversion pathway leading from cholesterol to bile acids synthesis, is encoded by CYP7A1 gene...
  58. Chen Q, Wang E, Ma L, Zhai P. Dietary resveratrol increases the expression of hepatic 7?-hydroxylase and ameliorates hypercholesterolemia in high-fat fed C57BL/6J mice. Lipids Health Dis. 2012;11:56 pubmed publisher
    ..We hypothesized that RSV decreases blood cholesterol levels through the activation of cholesterol 7?-hydroxylase (CYP7A1)-mediated bile acid synthetic pathway pathways in vitro and in vivo...
  59. Ellis E. Suppression of bile acid synthesis by thyroid hormone in primary human hepatocytes. World J Gastroenterol. 2006;12:4640-5 pubmed
    ..Expression of mRNA levels of cholesterol 7alpha-hydroxylase (CYP7A1) and sterol 12alpha-hydroxylase (CYP8B1) dose-dependently decreased...
  60. Shinkyo R, Xu L, Tallman K, Cheng Q, Porter N, Guengerich F. Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate. J Biol Chem. 2011;286:33021-8 pubmed publisher
    7-Ketocholesterol is a bioactive sterol, a potent competitive inhibitor of cytochrome P450 7A1, and toxic in liver cells. Multiple origins of this compound have been identified, with cholesterol being the presumed precursor...
  61. Kim K, Jeon H, Choi S, Tsang D, Oleszczuk P, Ok Y, et al. Combined toxicity of endosulfan and phenanthrene mixtures and induced molecular changes in adult Zebrafish (Danio rerio). Chemosphere. 2018;194:30-41 pubmed publisher
    ..b>CYP7A1 gene responsible for bile acid biosynthesis is dramatically down-regulated after exposure to the synergistic ..
  62. Li T, Chanda D, Zhang Y, Choi H, Chiang J. Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes. J Lipid Res. 2010;51:832-42 pubmed publisher
    ..High glucose stimulated bile acid synthesis and induced mRNA expression of cholesterol 7alpha-hydroxylase (CYP7A1), the key regulatory gene in bile acid synthesis...
  63. Takane H, Miyata M, Burioka N, Shigemasa C, Shimizu E, Otsubo K, et al. Pharmacogenetic determinants of variability in lipid-lowering response to pravastatin therapy. J Hum Genet. 2006;51:822-6 pubmed
    ..Cholesterol 7alpha-hydroxylase (CYP7A1) and apolipoprotein E (APOE) are known to contribute to lipid metabolism...
  64. Klos K, Sing C, Boerwinkle E, Hamon S, Rea T, Clark A, et al. Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants. Arterioscler Thromb Vasc Biol. 2006;26:1828-36 pubmed
    ..To identify common variations in genes in the reverse cholesterol transport pathway with nongender-specific influence on plasma lipid and apolipoprotein levels...
  65. Prasnicka A, Cermanova J, Hroch M, Dolezelova E, Rozkydalova L, Smutny T, et al. Iron depletion induces hepatic secretion of biliary lipids and glutathione in rats. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:1469-1480 pubmed publisher
    Iron depletion (ID) has been shown to induce the liver expression of Cyp7a1, the rate-limiting enzyme initiating conversion of cholesterol to bile acids (BA), although the effect on bile acids metabolism and bile production is unknown...
  66. Xu G, Pan L, Li H, Shang Q, Honda A, Shefer S, et al. Dietary cholesterol stimulates CYP7A1 in rats because farnesoid X receptor is not activated. Am J Physiol Gastrointest Liver Physiol. 2004;286:G730-5 pubmed
    Cholesterol feeding upregulates CYP7A1 in rats but downregulates CYP7A1 in rabbits...
  67. Wang M, Chen M, Zheng G, Dillard B, Tallarico M, Ortiz Z, et al. Transcriptional activation by growth hormone of HNF-6-regulated hepatic genes, a potential mechanism for improved liver repair during biliary injury in mice. Am J Physiol Gastrointest Liver Physiol. 2008;295:G357-66 pubmed publisher
    ..This was associated with increased expression of HNF-6 proliferative target genes cyclin D1 and metabolic gene Cyp7A1 and downregulation of profibrogenic TGFb2R...
  68. Zhang Y, Zhang Y, Klaassen C, Cheng X. Alteration of bile acid and cholesterol biosynthesis and transport by perfluorononanoic acid (PFNA) in mice. Toxicol Sci. 2017;: pubmed publisher
    ..mRNA expression of most BA-related transporters (Ntcp, Oatp1a1, Oatp1b2, and Bsep) and BA biosynthetic enzymes (Cyp7a1, 7b1, 8b1, and 27a1) in mouse liver, but increased mRNA expression of some efflux transporters (Bcrp, Mdr2, Mrp2, ..
  69. Wang J, Einarsson C, Murphy C, Parini P, Bjorkhem I, Gafvels M, et al. Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice. J Lipid Res. 2006;47:421-30 pubmed
    ..5%) or administration of a synthetic liver X receptor (LXR) agonist strongly upregulated CYP7A1 expression in CYP8B1-/- mice, compared to CYP8B1+/+ mice...
  70. Zhang C, Zhang R, Li Y, Liang N, Zhao Y, Zhu H, et al. Cholesterol-Lowering Activity of Tartary Buckwheat Protein. J Agric Food Chem. 2017;65:1900-1906 pubmed publisher
    ..and 8 (ABCG5/8) in a down trend, whereas it increased the gene expression of hepatic cholesterol-7? -hydroxylase (CYP7A1)...
  71. Li T, Chiang J. A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene. Gastroenterology. 2007;133:1660-9 pubmed
    Inhibition of cholesterol 7alpha-hydroxylase (CYP7A1) by bile acids and inflammatory cytokines provides an important mechanism to protect hepatocytes from bile acid toxicity during cholestasis...
  72. Song K, Li T, Owsley E, Chiang J. A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes. J Lipid Res. 2010;51:2223-33 pubmed publisher
    Cholesterol 7alpha-hydroxylase (CYP7A1) plays a critical role in regulation of bile acid synthesis in the liver. CYP7A1 mRNAs have very short half-lives, and bile acids destabilize CYP7A1 mRNA via the 3'-untranslated region (3'-UTR)...
  73. Radreau P, Porcherot M, Ramière C, Mouzannar K, Lotteau V, Andre P. Reciprocal regulation of farnesoid X receptor ? activity and hepatitis B virus replication in differentiated HepaRG cells and primary human hepatocytes. FASEB J. 2016;30:3146-54 pubmed publisher
    ..of these cells increased expression of FXR and modified expression of FXR-regulated genes SHP, APOA1, NTCP, CYP7A1, and CYP8B1 with a more pronounced effect in PHHs than in HepaRG cells...
  74. Lambrinoudaki I, Kaparos G, Papadimitriou D, Sergentanis T, Creatsa M, Alexandrou A, et al. Methylenetetrahydrofolate reductase C677T polymorphism is associated with central adiposity and increased androgenicity in healthy postmenopausal women. Eur J Endocrinol. 2008;159:233-41 pubmed publisher
    ..The significance of this association with respect to the CVD risk of postmenopausal women remains to be elucidated in future studies. ..
  75. Qrafli M, Amar Y, Bourkadi J, Ben Amor J, Iraki G, Bakri Y, et al. The CYP7A1 gene rs3808607 variant is associated with susceptibility of tuberculosis in Moroccan population. Pan Afr Med J. 2014;18:1 pubmed publisher
    ..The CYP7A1 gene is located in this region and codes for cholesterol 7a-hydroxylase, an enzyme involved in cholesterol ..
  76. Yamazaki T, Suehiro J, Miyazaki H, Minami T, Kodama T, Miyazono K, et al. The COUP-TFII variant lacking a DNA-binding domain inhibits the activation of the Cyp7a1 promoter through physical interaction with COUP-TFII. Biochem J. 2013;452:345-57 pubmed publisher
    ..effects on development and cell differentiation by regulating the transcription of its target genes, including Cyp7a1 (cytochrome P450, family 7, subfamily a, polypeptide 1), which plays important roles in catabolism of cholesterol ..
  77. Beigneux A, Hofmann A, Young S. Human CYP7A1 deficiency: progress and enigmas. J Clin Invest. 2002;110:29-31 pubmed
  78. Cui J, Heard T, Yu J, Lo J, Huang L, Li Y, et al. The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate. J Biol Chem. 2002;277:25963-9 pubmed
    ..This study not only provides the identification of critical residues for FXR function but may also explain the species difference in bile acids/cholesterol metabolism...
  79. Casagrande V, Mauriello A, Bischetti S, Mavilio M, Federici M, Menghini R. Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma. Sci Rep. 2017;7:6747 pubmed publisher
    ..In AlbT3 mice CYP7A1, MDR3 and MRP2 gene expressions were observed, consistent with higher bile acid synthesis and export...
  80. Wertheim B, Smith J, Fang C, Alberts D, Lance P, Thompson P. Risk modification of colorectal adenoma by CYP7A1 polymorphisms and the role of bile acid metabolism in carcinogenesis. Cancer Prev Res (Phila). 2012;5:197-204 pubmed publisher
    Cholesterol 7?-hydroxylase (CYP7A1), the rate-limiting enzyme in the conversion of cholesterol to bile acids, is a postulated gene modifier of colorectal cancer risk and target for the therapeutic bile acid, ursodeoxycholic acid (UDCA)...