CYP4V2

Summary

Gene Symbol: CYP4V2
Description: cytochrome P450, family 4, subfamily V, polypeptide 2
Alias: BCD, CYP4AH1, cytochrome P450 4V2
Species: human

Top Publications

  1. pmc Bietti crystalline corneoretinal dystrophy is caused by mutations in the novel gene CYP4V2
    Anren Li
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, Bethesda, MD 20892, USA
    Am J Hum Genet 74:817-26. 2004
  2. pmc An atypical form of Bietti crystalline dystrophy
    Settimio Rossi
    Department of Ophthalmology, Second University of Naples, Napoli, Italy
    Ophthalmic Genet 32:118-21. 2011
  3. ncbi Novel mutations in the CYP4V2 gene associated with Bietti crystalline corneoretinal dystrophy
    Minghua Shan
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China
    Mol Vis 11:738-43. 2005
  4. doi Identification of CYP4V2 mutation in 21 families and overview of mutation spectrum in Bietti crystalline corneoretinal dystrophy
    Xueshan Xiao
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, PR China
    Biochem Biophys Res Commun 409:181-6. 2011
  5. pmc Clinical and molecular findings in three Lebanese families with Bietti crystalline dystrophy: report on a novel mutation
    Nour Maya N Haddad
    Service d Ophtalmologie, Hotel Dieu de France Hospital, Beirut, Lebanon
    Mol Vis 18:1182-8. 2012
  6. pmc Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states
    Edward J Kelly
    Department of Pharmaceutics, University of Washington, Seattle, WA 98195, USA
    Mol Interv 11:124-32. 2011
  7. pmc Molecular screening of the CYP4V2 gene in Bietti crystalline dystrophy that is associated with choroidal neovascularization
    Gandra Mamatha
    SN ONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India
    Mol Vis 17:1970-7. 2011
  8. ncbi Genotype phenotype analysis of Bietti's crystalline dystrophy in patients with CYP4V2 mutations
    Timothy Y Y Lai
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong
    Invest Ophthalmol Vis Sci 48:5212-20. 2007
  9. ncbi Clinical and molecular findings in three Japanese patients with crystalline retinopathy
    Zi Bing Jin
    Department of Ophthalmology and Visual Science, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Jpn J Ophthalmol 50:426-31. 2006
  10. ncbi Characterization of Bietti crystalline dystrophy patients with CYP4V2 mutations
    Kelvin Y C Lee
    Singapore National Eye Centre
    Invest Ophthalmol Vis Sci 46:3812-6. 2005

Research Grants

Detail Information

Publications146 found, 100 shown here

  1. pmc Bietti crystalline corneoretinal dystrophy is caused by mutations in the novel gene CYP4V2
    Anren Li
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, Bethesda, MD 20892, USA
    Am J Hum Genet 74:817-26. 2004
    ..by D4S2924 by linkage and haplotype analysis; mutations were found in the novel CYP450 family member CYP4V2 in 23 of 25 unrelated patients with BCD tested...
  2. pmc An atypical form of Bietti crystalline dystrophy
    Settimio Rossi
    Department of Ophthalmology, Second University of Naples, Napoli, Italy
    Ophthalmic Genet 32:118-21. 2011
    ..To describe clinical and functional features of a patient with Bietti crystalline dystrophy and atypical electroretinogram responses...
  3. ncbi Novel mutations in the CYP4V2 gene associated with Bietti crystalline corneoretinal dystrophy
    Minghua Shan
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China
    Mol Vis 11:738-43. 2005
    ..Recently mutations in a new gene CYP4V2, encoding a protein belonging to a novel member of the cytochrome P450 family, have been identified as the cause ..
  4. doi Identification of CYP4V2 mutation in 21 families and overview of mutation spectrum in Bietti crystalline corneoretinal dystrophy
    Xueshan Xiao
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, PR China
    Biochem Biophys Res Commun 409:181-6. 2011
    ..BCD is caused by CYP4V2 mutations...
  5. pmc Clinical and molecular findings in three Lebanese families with Bietti crystalline dystrophy: report on a novel mutation
    Nour Maya N Haddad
    Service d Ophtalmologie, Hotel Dieu de France Hospital, Beirut, Lebanon
    Mol Vis 18:1182-8. 2012
    ..rare autosomal recessive disorder caused by mutation of the cytochrome P450, family 4, subfamily V, polypeptide 2 (CYP4V2) gene and characterized by retinal pigmentary abnormalities and scattered deposits of crystals in the retina and ..
  6. pmc Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states
    Edward J Kelly
    Department of Pharmaceutics, University of Washington, Seattle, WA 98195, USA
    Mol Interv 11:124-32. 2011
    ..Human CYP4V2 and CYP4F22 are two such orphan P450s that are strongly linked to ocular andskin disease, respectively...
  7. pmc Molecular screening of the CYP4V2 gene in Bietti crystalline dystrophy that is associated with choroidal neovascularization
    Gandra Mamatha
    SN ONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India
    Mol Vis 17:1970-7. 2011
    ..The disease is caused by mutation in the cytochrome p450, family 4, subfamily v, polypeptide 2 (CYP4V2) gene. Choroidal neovascularization (CNV) is a rare event in BCD. We report two cases of BCD associated with CNV...
  8. ncbi Genotype phenotype analysis of Bietti's crystalline dystrophy in patients with CYP4V2 mutations
    Timothy Y Y Lai
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong
    Invest Ophthalmol Vis Sci 48:5212-20. 2007
    To evaluate the genotypic and phenotypic correlations of Bietti's crystalline dystrophy (BCD) in patients with the CYP4V2 gene by mutation screening and clinical and electrophysiological assessment.
  9. ncbi Clinical and molecular findings in three Japanese patients with crystalline retinopathy
    Zi Bing Jin
    Department of Ophthalmology and Visual Science, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Jpn J Ophthalmol 50:426-31. 2006
    To identify CYP4V2 mutations in three unrelated Japanese patients with Bietti crystalline corneoretinal dystrophy (BCD).
  10. ncbi Characterization of Bietti crystalline dystrophy patients with CYP4V2 mutations
    Kelvin Y C Lee
    Singapore National Eye Centre
    Invest Ophthalmol Vis Sci 46:3812-6. 2005
    Mutations of the CYP4V2 gene, a novel family member of the cytochrome P450 genes on chromosome 4q35, have recently been identified in patients with Bietti crystalline dystrophy (BCD)...
  11. ncbi Screening for mutations in CYP4V2 gene in Japanese patients with Bietti's crystalline corneoretinal dystrophy
    Yuko Wada
    Department of Ophthalmology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 77, Japan
    Am J Ophthalmol 139:894-9. 2005
    To describe the clinical and genetic characteristics of six Japanese families with Bietti's crystalline corneoretinal dystrophy (BCD).
  12. ncbi CYP4V2 mutations in two Japanese patients with Bietti's crystalline dystrophy
    Tamaki Gekka
    Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan
    Ophthalmic Res 37:262-9. 2005
    ..The purpose of this study was to report mutations in the CYP4V2 gene (encoding a ubiquitously-expressed 525-amino acid sequence belonging to the CYP450 family) and to investigate ..
  13. pmc Cloning, sequencing, and expression of clustered genes encoding beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase, crotonase, and butyryl-CoA dehydrogenase from Clostridium acetobutylicum ATCC 824
    Z L Boynton
    Department of Biochemistry and Cell Biology, The Institute of Biosciences and Bioengineering, Rice University, Houston, Texas 77005 1892, USA
    J Bacteriol 178:3015-24. 1996
    The enzymes beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase (BHBD), crotonase, and butyryl-CoA dehydrogenase (BCD) from Clostridium acetobutylicum are responsible for the formation of butyryl-CoA from acetoacetyl-CoA...
  14. pmc Involvement of NADH:acceptor oxidoreductase and butyryl coenzyme A dehydrogenase in reversed electron transport during syntrophic butyrate oxidation by Syntrophomonas wolfei
    Nicolai Müller
    Fachbereich Biologie, Universitat Konstanz, Constance, Germany
    J Bacteriol 191:6167-77. 2009
    ..Furthermore, purification of butyryl-CoA dehydrogenase (Bcd) activity and peptide mass fingerprinting revealed two Bcd proteins different from the Bcd subunit of the Bcd/..
  15. ncbi Use of modified Lactobacillus selective medium and Bifidobacterium iodoacetate medium for differential enumeration of Lactobacillus acidophilus and Bifidobacterium spp. in powdered nutritional products
    S C Ingham
    University of Wisconsin Madison, Department of Food Science, 53706 1565, USA
    J Food Prot 62:77-80. 1999
    ..5 mg iodoacetic acid/liter; mBIM) was compared to MRS agar + bile, cysteine, and dicloxacillin (MRS + BCD) for enumerating Bifidobacterium infantis or Bifidobacterium lactis in the nutritional products...
  16. ncbi Expression of selected T-cell antigens in the skin infiltration in primary cutaneous T-cell lymphomas
    D Wojnowska
    Department of Dermatology, Medical University of Lublin
    Ann Univ Mariae Curie Sklodowska Med 56:237-42. 2001
    ..Cases of benign chronic skin disorders (BCD) were included in control group...
  17. ncbi High-performance liquid chromatography coupled to enzyme-amplified biochemical detection for the analysis of hemoglobin after pre-column biotinylation
    M R van Bommel
    Division of Analytical Chemistry, Leiden/Amsterdam Center of Drug Research, Leiden University, The Netherlands
    J Chromatogr A 886:19-29. 2000
    The determination of proteins with enzyme-amplified biochemical detection (EA-BCD) coupled on-line with high-performance liquid chromatography (HPLC) is demonstrated. The EA-BCD system was developed to detect biotin-containing compounds...
  18. ncbi Identification and hepatic expression profiles of cytochrome P450 1-4 isozymes in common minke whales (Balaenoptera acutorostrata)
    Satoko Niimi
    Center for Marine Environmental Studies CMES, Ehime University, Bunkyo cho 2 5, Matsuyama 790 8577, Japan
    Comp Biochem Physiol B Biochem Mol Biol 147:667-81. 2007
    ..high identities with cattle CYP2C86 (83%), pig CYP2E1 (85%), sheep CYP3A24 (82%), pig CYP4A21 (80%), and human CYP4V2 (76%), respectively...
  19. ncbi Enzyme amplification as detection tool in continuous-flow systems. II. On-line coupling of liquid chromatography to enzyme-amplified biochemical detection after pre-column derivatization with biotin
    M R van Bommel
    Division of Analytical Chemistry, Leiden/Amsterdam Center of Drug Research, Leiden University, The Netherlands
    J Chromatogr A 855:397-409. 1999
    Enzyme-amplified biochemical detection (EA-BCD) was used as a post-column detection technique, coupled on-line with high-performance liquid chromatography (HPLC)...
  20. doi Inhibition of three selected beverage extracts on alpha-glucosidase and rapid identification of their active compounds using HPLC-DAD-MS/MS and biochemical detection
    De Qiang Li
    Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China
    J Agric Food Chem 58:6608-13. 2010
    ..online liquid chromatography-diode array detection-tandem mass spectrometry and biochemical detection (LC-DAD-MS/MS-BCD) was developed to screen and identify alpha-glucosidase inhibitors from selected beverage extracts, including pu-..
  21. doi Influence of supplemental dietary poultry fat, phytase, and 25-hydroxycholecalciferol on the performance of commercial layers inoculated before or at the onset of lay with F-strain Mycoplasma gallisepticum
    S W Park
    Department of Poultry Science, Mississippi State University, Mississippi State 39762, USA
    Poult Sci 89:910-6. 2010
    ..were administered at 12 (before lay) and 22 (early in lay) wk and dietary treatments [basal control diet (BCD), BCD with 0.75% supplemental PF, BCD with 1.50% supplemental PF, and BCD with 1.50% supplemental PF, 0...
  22. ncbi Blood pressure in relation to biomarkers of lead, cadmium, copper, zinc, and selenium in men without occupational exposure to metals
    S Telisman
    Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Environ Res 87:57-68. 2001
    ..BPb), activity of delta-aminolevulinic acid dehydratase (ALAD), erythrocyte protoporphyrin (EP), blood cadmium (BCd), serum copper (SCu), serum zinc (SZn), serum selenium (SSe), hematocrit (Hct), body mass index (BMI), age, smoking ..
  23. ncbi Expression of Clostridium acetobutylicum butanol synthetic genes in Escherichia coli
    Masayuki Inui
    Research Institute of Innovative Technology for the Earth, Kizugawa, Kyoto, Japan
    Appl Microbiol Biotechnol 77:1305-16. 2008
    A recombinant butanol pathway composed of Clostridium acetobutylicum ATCC 824 genes, thiL, hbd, crt, bcd-etfB-etfA, and adhe1 (or adhe) coding for acetyl-CoA acetyltransferase (THL), beta-hydroxybutyryl-CoA dehydrogenase (HBD), 3-..
  24. ncbi Lead effect on blood pressure in moderately lead-exposed male workers
    Spomenka Telisman
    Department of Occupational and Environmental Health, Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Am J Ind Med 45:446-54. 2004
    ..The effect of lead (Pb) and potential confounding variables on blood pressure was examined in healthy male industrial workers 20-43 years of age...
  25. ncbi Binding of N-acetylglucosamine oligosaccharides to hen egg-white lysozyme: a powder diffraction study
    R B Von Dreele
    XPS IPNS Divisions, Argonne National Laboratory, Argonne, IL 60439, USA
    Acta Crystallogr D Biol Crystallogr 61:22-32. 2005
    ..The NAG2 ligand was found in the BC sites in the cleft of HEWL, NAG3 was found to bind in both the ABC and BCD sites in the ratio 35:65 and NAG4 and NAG5 bound to the ABCD and ABCDE sites, respectively, while NAG6 only bound ..
  26. ncbi Pathology of Hematodinium infections in snow crabs (Chionoecetes opilio) from Newfoundland, Canada
    Kersten Wheeler
    Virginia Institute of Marine Science, The College of William and Mary, School of Marine Science, Gloucester Point, VA 23062, USA
    J Invertebr Pathol 95:93-100. 2007
    Bitter crab disease (BCD) of snow crabs, Chionoecetes opilio, is caused by a parasitic dinoflagellate, Hematodinium sp...
  27. ncbi Cholesterol is essential for macrophage inflammatory protein 1 beta binding and conformational integrity of CC chemokine receptor 5
    Dzung H Nguyen
    Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Blood 99:4298-306. 2002
    ..We found that cholesterol extraction by hydroxypropyl-beta-cyclodextrin (BCD) significantly reduced the binding and signaling of macrophage inflammatory protein 1 beta (MIP-1 beta) using CCR5-..
  28. pmc Empty spiracles, a gap gene containing a homeobox involved in Drosophila head development
    U Walldorf
    Department of Cell Biology, University of Basel, Switzerland
    EMBO J 11:2247-59. 1992
    ..The early expression of the ems gene is controlled by the anterior morphogen bicoid (bcd). Using a gene fusion we identified a cis-acting element which is a target for the bcd gene product...
  29. pmc Inhibition of expression of P-selectin by antioxidant in cholesterol-fed rats
    C S Lee
    Department of Pathology, Chungnam National University College of Medicine, Taejon, Korea
    J Korean Med Sci 14:8-14. 1999
    ..5% cholesterol and 0.1% sodium cholate (CD), or the CD diet containing 0.5% BHT (BCD). Rats were sacrificed after 3 days, and after 1, 2, 4, 10, and 17 weeks of dietary treatment...
  30. doi Development of a liquid chromatography-based screening methodology for proteolytic enzyme activity
    Nils Helge Schebb
    Westfalische Wilhelms Universitat Munster, Institut fur Anorganische und Analytische Chemie, Corrensstrasse 30, 48149 Munster, Germany
    J Chromatogr A 1216:4407-15. 2009
    ..detection of the responsible enzymes by means of liquid chromatography hyphenated online to biochemical detection (BCD)...
  31. ncbi Null allele at Bcd-1 locus in BALB/cByJ mice is due to a deletion in the short-chain acyl-CoA dehydrogenase gene and results in missplicing of mRNA
    M E Hinsdale
    Department of Comparative Medicine, School of Medicine, University of Alabama, Birmingham 35294 0019
    Genomics 16:605-11. 1993
    ..Both abnormal transcripts have aberrant stop codons. These results demonstrate the molecular basis of SCAD deficiency in this unique mouse model...
  32. pmc Rapid screening for depression--validation of the Brief Case-Find for Depression (BCD) in medical oncology and palliative care patients
    M Jefford
    Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Victoria 8006, Australia
    Br J Cancer 91:900-6. 2004
    ..Screening can increase case recognition. The Brief Case-Find for Depression (BCD) is a four-question, interviewer-administered instrument that has been previously validated in a general medical ..
  33. ncbi Characterization and transcription of the genes involved in butyrate production in Butyrivibrio fibrisolvens type I and II strains
    Narito Asanuma
    Department of Life Science, College of Agriculture, Meiji University, Higashimita, Tama ku, Kawasaki 214 8571, Japan
    Curr Microbiol 51:91-4. 2005
    ..from acetyl-CoA to butyryl-CoA, thl (thiolase), crt (crotonase), hbd (beta-hydroxybutyryl-CoA dehydrogenase), bcd (butyryl-CoA dehydrogenase), etfB (electron transfer flavoprotein [ETF]-beta), and etfA (ETF-alpha), were found to ..
  34. pmc Cadmium-related mortality and long-term secular trends in the cadmium body burden of an environmentally exposed population
    Tim S Nawrot
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Herestraat 49, Leuven, Belgium
    Environ Health Perspect 116:1620-8. 2008
    ..Few population studies have reported on the long-term changes in the internal cadmium dose and simultaneously occurring mortality...
  35. doi Reconstructing the clostridial n-butanol metabolic pathway in Lactobacillus brevis
    Oksana V Berezina
    State Research Institute of Genetics and Selection of Industrial Microorganisms, 1st Dorojniy pr 1, 117545, Moscow, Russian Federation
    Appl Microbiol Biotechnol 87:635-46. 2010
    ..The genes crt, bcd, etfB, etfA, and hbd, composing the bcs-operon, and the thl gene encode the enzymes of the lower part of the ..
  36. ncbi Epidemiology of bitter crab disease (Hematodinium sp.) in snow crabs Chionoecetes opilio from Newfoundland, Canada
    Jeffrey D Shields
    Virginia Institute of Marine Science, The College of William and Mary, Gloucester Point, Virginia 23062, USA
    Dis Aquat Organ 64:253-64. 2005
    The parasitic dinoflagellate Hematodinium sp. causes a condition known as bitter crab disease (BCD) in snow crabs Chionoecetes opilio and Tanner crabs C. bairdi...
  37. ncbi Epidemiological determinants in outbreaks of bitter crab disease (Hematodinium sp.) in snow crabs Chionoecetes opilio from Conception Bay, Newfoundland, Canada
    Jeffrey D Shields
    Virginia Institute of Marine Science, The College of William and Mary, Gloucester Point, Virginia 23062, USA
    Dis Aquat Organ 77:61-72. 2007
    Bitter crab disease (BCD) is caused by Hematodinium sp., an endoparasitic dinoflagellate. It lives within the hemocoeloms of snow crabs Chionoecetes opilio and Tanner crabs C. bairdi, making them unmarketable due to their bitter flavor...
  38. ncbi Mutation of Escherichia coli cytosine deaminase significantly enhances molecular chemotherapy of human glioma
    S A Kaliberov
    Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Gene Ther 14:1111-9. 2007
    ..We have developed an Ad vector encoding a mutant bacterial cytosine deaminase (bCD) gene (AdbCD-D314A), which has a higher affinity for cytosine than wild-type bCD (bCDwt)...
  39. ncbi Localized maternal orthodenticle patterns anterior and posterior in the long germ wasp Nasonia
    Jeremy A Lynch
    Center for Developmental Genetics, NYU Biology, 100 Washington Square East New York, New York 10003, USA
    Nature 439:728-32. 2006
    The Bicoid (Bcd) gradient in Drosophila has long been a model for the action of a morphogen in establishing embryonic polarity. However, it is now clear that bcd is a unique feature of higher Diptera...
  40. ncbi A comparison of bicarbonate hemodialysis, hemodiafiltration, and acetate-free biofiltration on cytokine production
    Terumi Higuchi
    Department of Medicine, Division of Nephrology and Endocrinology, Nihon University School of Medicine, Tokyo 170 0032, Japan
    Ther Apher Dial 8:460-7. 2004
    ..of this study was to investigate the difference of cytokine production by conventional bicarbonate hemodialysis (BCD), standard HDF and AFB in the same patients...
  41. ncbi The PucC protein of Rhodobacter capsulatus mitigates an inhibitory effect of light-harvesting 2 alpha and beta proteins on light-harvesting complex 1
    Paul R Jaschke
    Department of Microbiology and Immunology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada, V6T 1Z3
    Photosynth Res 95:279-84. 2008
    ..genes, and homologues in other photosynthetic organisms, have been classified as the bacteriochlorophyll delivery (BCD) family of the major facilitator superfamily...
  42. ncbi Characterization of a cyclodextrinoligonucleotide complex by capillary electrophoresis using laser-induced fluorescence
    Jeffrey W Guthrie
    Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry and School of Public Health, University of Alberta, Edmonton, Alberta, Canada
    J Pharm Pharm Sci 10:246-55. 2007
    ....
  43. pmc Target selectivity of bicoid is dependent on nonconsensus site recognition and protein-protein interaction
    C Zhao
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Mol Cell Biol 20:8112-23. 2000
    We describe experiments to compare the activities of two Drosophila homeodomain proteins, Bicoid (Bcd) and an altered-specificity mutant of Fushi tarazu, Ftz(Q50K)...
  44. doi DNA ploidy abnormalities in basal and superficial regions of the crypts in Barrett's esophagus and associated neoplastic lesions
    Xiaoqi Zhang
    Departments of Medicine, Veterans Affairs Boston Healthcare System, Harvard Medical School, West Roxbury, MA 02132, USA
    Am J Surg Pathol 32:1327-35. 2008
    ..01) from nondysplastic BE to basal crypt dysplasia (BCD), low-grade dysplasia (LGD), high-grade dysplasia (HGD), and adenocarcinoma (AC)...
  45. doi Molecular chemotherapy of pancreatic cancer using novel mutant bacterial cytosine deaminase gene
    Lyudmila N Kaliberova
    Department of Radiation Oncology, University of Alabama at Birmingham, 1530 3rd Avenue South, WTI 674, Birmingham, AL 35294 6832, USA
    Mol Cancer Ther 7:2845-54. 2008
    ..We have developed an adenoviral vector (AdbCD-D314A) encoding a mutant bacterial cytosine deaminase (bCD) gene, which converts the prodrug 5-fluorocytosine (5-FC) into the active drug 5-fluorouracil...
  46. pmc Bacterial cytosine deaminase mutants created by molecular engineering show improved 5-fluorocytosine-mediated cell killing in vitro and in vivo
    Michi Fuchita
    School of Molecular Biosciences and Department of Pharmaceutical Sciences, Washington State University, Pullman, Washington 99164 6534, USA
    Cancer Res 69:4791-9. 2009
    ..we reported individual point mutations within the substrate binding pocket of bacterial cytosine deaminase (bCD) that result in marginal improvements in the ability to sensitize cells to 5-fluorocytosine (5FC)...
  47. ncbi Anterior repression of a Drosophila stripe enhancer requires three position-specific mechanisms
    Luiz Paulo Moura Andrioli
    Department of Biology, New York University, 1009 Main Building, 100 Washington Square East, New York 10003 6688, USA
    Development 129:4931-40. 2002
    ..The enhancer for eve stripe 2 (eve 2) is directly activated by the morphogens Bicoid (Bcd) and Hunchback (Hb)...
  48. doi Air-handling capabilities of blood cardioplegia delivery systems in a simulated pediatric model
    David Palanzo
    Heart and Vascular Institute, Penn State Hershey College of Medicine, Penn State Hershey Children s Hospital Hershey, PA 17033 0850, USA
    Artif Organs 34:950-4. 2010
    ..following cardioplegia delivery systems: GISH Vision, Maquet Plegiox, Medtronic Trillium MYOtherm XP, Sorin Group BCD Vanguard, Sorin Group CSC14, and Terumo Sarns Conducer and Bubble Trap. The 0.25-in...
  49. ncbi Bridge to dentistry: one dental school's approach to improving its enrollment of underrepresented minorities
    Ernestine S Brooks
    Baylor College of Dentistry, Texas A and M University System Health Science Center, Dallas, TX, USA
    J Am Coll Dent 69:23-30. 2002
    ..53%. This trend is evident at Baylor College of Dentistry (BCD)...
  50. pmc Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase
    Mariko Nakano
    Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA 98195 7610, USA
    Drug Metab Dispos 37:2119-22. 2009
    Bietti's crystalline dystrophy is an ocular disease that is strongly associated with polymorphisms in the CYP4V2 gene...
  51. pmc Bicoid functions without its TATA-binding protein-associated factor interaction domains
    V Schaeffer
    Howard Hughes Medical Institute, The Rockefeller University, Box 151, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 96:4461-6. 1999
    ..The key component of the anterior system is the homeodomain protein Bicoid (Bcd)...
  52. ncbi Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model
    Florian Graepler
    Department of Internal Medicine I, Medical University Clinic Tubingen, Germany
    World J Gastroenterol 11:6910-9. 2005
    ..To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model...
  53. ncbi [Stricture recanalisation of the distal urether with various endoprothesis]
    A Mladenovic
    Centar za radiologiju, Odeljenje KCS, Beograd
    Acta Chir Iugosl 57:61-4. 2010
    ..of continous development of the new generation methods percutaneous nephrostomy (PCN), ballon catheter dilatation (BCD), methal and covered stent application...
  54. pmc Blood and urine cadmium, blood pressure, and hypertension: a systematic review and meta-analysis
    Carolyn M Gallagher
    Doctoral Program in Population Health and Clinical Outcomes Research, Stony Brook University Medical Center, Stony Brook, New York, USA
    Environ Health Perspect 118:1676-84. 2010
    ..Cadmium exposure has been inconsistently related to blood pressure...
  55. ncbi Enzyme amplification as detection tool in continuous-flow systems. I. Development of an enzyme-amplified biochemical detection system coupled on-line to flow-injection analysis
    M R van Bommel
    Division of Analytical Chemistry, Leiden/Amsterdam Center of Drug Research, Leiden University, The Netherlands
    J Chromatogr A 855:383-96. 1999
    The on-line coupling of flow-injection analysis (FIA) to an enzyme-amplified biochemical detection (EA-BCD) system is described...
  56. pmc The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features
    Henning Seedorf
    Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany
    Proc Natl Acad Sci U S A 105:2128-33. 2008
    ..energy-converting NADH:ferredoxin oxidoreductase (RnfCDGEAB) and a cytoplasmic butyryl-CoA dehydrogenase complex (Bcd/EtfAB) coupling the reduction of crotonyl-CoA to butyryl-CoA with the reduction of ferredoxin represent a new ..
  57. doi Structure and binding of peptide-dendrimer ligands to vitamin B12
    Nicolas A Uhlich
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    Chembiochem 11:358-65. 2010
    ..Substituting glutamates (E) for glutamines (Q) in the outer branches of B1 to form N3 (AcQS)8(BQA)4(B-Amb-Y)(2)BCD-NH2 leads to stronger (K(a)=12.0 x 10(6) M(-1)) but slower (k(2)=67 M(-1) s(-1)) cobalamin binding...
  58. doi Imperforate anus is a rare associated finding in blepharocheilodontic syndrome
    K Nicole Weaver
    University of Alabama School of Medicine, Birmingham, Alabama, USA
    Am J Med Genet A 152:438-40. 2010
    Blepharocheilodontic (BCD) syndrome is a rare autosomal-dominant condition that is characterized by lower eyelid ectropion, upper eyelid distichiasis, euryblepharon, bilateral cleft lip and palate, and conical teeth...
  59. ncbi Blepharo-cheilo-dontic (BCD) syndrome: case report
    Akihiko Iida
    Division of Oral and Maxillofacial Surgery, Niigata University Graduate School of Medical and Dental Sciences, 2 5274 Gakkocho dori, Niigata 951 8514, Japan
    Cleft Palate Craniofac J 43:237-43. 2006
    To report a case of blepharo-cheilo-dontic (BCD) syndrome, to compare with the previous cases, and to discuss the possible treatment.
  60. pmc Nanoplex delivery of siRNA and prodrug enzyme for multimodality image-guided molecular pathway targeted cancer therapy
    Cong Li
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States
    ACS Nano 4:6707-16. 2010
    ..up-regulated in aggressive breast cancer cells, was combined with the prodrug enzyme bacterial cytosine deaminase (bCD) that converts the nontoxic prodrug 5-fluorocytosine (5-FC) to cytotoxic 5-fluorouracil (5-FU)...
  61. ncbi Multiple steps in the localization of bicoid RNA to the anterior pole of the Drosophila oocyte
    D St Johnston
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, FRG
    Development 107:13-9. 1989
    The anterior region of the Drosophila embryonic pattern is determined by a gradient of the bicoid (bcd) protein. The correct formation of this gradient requires the localization of bcd RNA to the anterior pole of the egg...
  62. doi Effects of cadmium on forearm bone density after reduction of exposure for 10 years in a Chinese population
    Xiao Chen
    Institute of Radiation Medicine, Fudan University, 200032, Shanghai, China
    Environ Int 35:1164-8. 2009
    ..Samples of urine and blood were collected for determination of cadmium in urine (UCd) and blood (BCd)...
  63. ncbi Organic substrate quality as the link between bacterioplankton carbon demand and growth efficiency in a temperate salt-marsh estuary
    Jude K Apple
    Horn Point Laboratory, University of Maryland Center for Environmental Science, Cambridge, MD, USA
    ISME J 1:729-42. 2007
    ..Studies of bacterioplankton carbon demand (BCD) and growth efficiency (BGE) frequently report higher values in more productive systems, suggesting these aspects ..
  64. pmc Enhancer sequences influence the role of the amino-terminal domain of bicoid in transcription
    Dechen Fu
    Graduate Program in Molecular and Developmental Biology, Division of Developmental Biology, Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Mol Cell Biol 23:4439-48. 2003
    Bicoid (Bcd) is a Drosophila melanogaster morphogenetic gradient that controls embryonic patterning by activating target gene expression in a concentration-dependent manner...
  65. ncbi Spectral OCT analysis in Bietti crystalline dystrophy
    David Gaucher
    Service d Ophtalmologie du Nouvel Hopital Civil, Hopitaux Universitaires de Strasbourg, Strasbourg Cedex France
    Eur J Ophthalmol 20:612-4. 2010
    To report the analysis of the cornea and the macular retina using both time domain (TD-OCT) and Fourier domain optical coherence tomography (FD-OCT) in a case of Bietti crystalline dystrophy (BCD).
  66. doi Fracture of bony lamellae within the frontal recess after balloon catheter dilatation
    Ayesha N Khalid
    Division of Rhinology, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, USA
    Am J Rhinol Allergy 24:55-9. 2010
    The precise manner in which balloon catheter dilatation (BCD) alters the dimensions of the frontal recess and frontal sinus outflow tract is not well characterized...
  67. ncbi Identification of a new C28H14 polycyclic aromatic hydrocarbon as a product of supercritical fuel pyrolysis: Tribenzo[cd,ghi,lm]perylene
    Jennifer W McClaine
    Department of Chemical Engineering, Louisiana State University, South Stadium Drive, Baton Rouge, LA 70803, USA
    J Chromatogr A 1138:175-83. 2007
    ..phenanthro[5,4,3,2-efghi]perylene, benzo[cd]naphtho[3,2,1,8-pqra]perylene, and benzo[pqr]naphtho[8,1,2-bcd]perylene--have already been identified as supercritical pyrolysis products by matching their UV spectra with those ..
  68. pmc Spatial bistability generates hunchback expression sharpness in the Drosophila embryo
    Francisco J P Lopes
    Department of Applied Mathematics, Stony Brook University, Stony Brook, New York, United States of America
    PLoS Comput Biol 4:e1000184. 2008
    ..the hunchback (hb) gene at midembryo, in response to local concentrations of the smooth anterior-posterior Bicoid (Bcd) gradient...
  69. doi Enhanced immune response to pneumococcal infection in malnourished mice nasally treated with heat-killed Lactobacillus casei
    Julio Villena
    Reference Center for Lactobacilli CERELA CONICET, Tucuman, Argentina
    Microbiol Immunol 53:636-46. 2009
    ..Weaned mice were malnourished after consuming a PFD for 21 days. Malnourished mice were fed a BCD for 7 days or BCD for 7 days with viable or non-viable L...
  70. doi A novel sample preparation and on-line HPLC-DAD-MS/MS-BCD analysis for rapid screening and characterization of specific enzyme inhibitors in herbal extracts: Case study of α-glucosidase
    D Q Li
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    J Pharm Biomed Anal 88:130-5. 2014
    ..liquid chromatography-diode array detection-tandem mass spectrometry and biochemical detection (HPLC-DAD-MS/MS-BCD) was performed to rapidly screen and characterize α-glucosidase inhibitors in these four extracts...
  71. ncbi Fibronectin-binding proteins of Staphylococcus aureus mediate activation of human platelets via fibrinogen and fibronectin bridges to integrin GPIIb/IIIa and IgG binding to the FcgammaRIIa receptor
    J Ross Fitzgerald
    Department of Microbiology, Moyne Institute of Preventive Medicine, University of Dublin, Trinity College, Dublin, Ireland
    Mol Microbiol 59:212-30. 2006
    ..Truncated derivatives of FnBPA, presenting either the fibrinogen-binding A domain or the fibronectin-binding BCD region, each promoted platelet activation when expressed on the surface of S...
  72. ncbi Genetics and ontogeny of butyryl CoA dehydrogenase in the mouse and linkage of Bcd-1 with Dao-1
    T L Seeley
    Biochem Genet 19:333-45. 1981
    ..for fatty acyl CoA dehydrogenase and used to examine the electrophoretic properties of butyryl CoA dehydrogenase (BCD) from mouse tissues. A single form of BCD is present in extracts of liver, kidney, heart, and intestine...
  73. ncbi Removal of heavy metals from waste waters by vermiculites
    E Alvarez-Ayuso
    Department of Environmental Geochemistry, IRNASA, CSIC, Apto 257, Salamanca, Spain
    Environ Technol 24:615-25. 2003
    ..the sorption processes well, showing the maximum sorption capacities of natural vermiculite to be high enough (bCd = 26.0 mg g(-1); performed bCd = 23.5 mg g(-1); bNi = 19...
  74. ncbi Radical and palladium-catalyzed cyclizations to cyclobutenes: an entry to the BCD ring system of penitrem D
    Alexey Rivkin
    Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Org Chem 69:3719-25. 2004
    A novel approach toward the synthesis of the BCD ring system of penitrem D is described...
  75. ncbi [Evolutionary theories of asymmetrization of organisms, brain and body]
    V A Geodakian
    Usp Fiziol Nauk 36:24-53. 2005
    ..of elements of unitary systems (US) inevitably transfrorms them into the binary connected differentiations (BCD)...
  76. ncbi Relationship between molecular structure and electron targets in the electroreduction of benzocarbazolediones and anilinenaphthoquinones. Experimental and theoretical study
    N Macías-Ruvalcaba
    Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico D F, Mexico
    J Org Chem 67:3673-81. 2002
    We report the synthesis and voltamperometric reduction of 5H-benzo[b]carbazole-6,11-dione (BCD) and its 2-R-substituted derivatives (R = -OMe, -Me, -COMe, -CF(3))...
  77. doi Nasally administered Lactobacillus rhamnosus accelerate the recovery of humoral immunity in B lymphocyte-deficient malnourished mice
    Natalia Barbieri
    Reference Centre for Lactobacilli CERELA CONICET, Tucuman, Argentina
    J Nutr 143:227-35. 2013
    ..Malnourished mice were fed a balanced conventional diet (BCD) for 7 d (BCD group) or a BCD for 7 d with supplemental L...
  78. doi Modulation of the immuno-coagulative response in a pneumococcal infection in malnourished mice nasally treated with Lactobacillus casei
    Hortensia Zelaya
    Bioquímica Clínica I, Instituto de Bioquímica Aplicada, Facultad de Bioquimica, Quimica y Farmacia, Universidad Nacional de Tucuman, San Miguel de Tucuman, Argentina
    J Med Microbiol 62:145-54. 2013
    ..Malnourished mice were fed a balanced conventional diet (BCD) for 7 days (BCD group) or a BCD for 7 days with nasal administration of viable L...
  79. pmc A system of repressor gradients spatially organizes the boundaries of Bicoid-dependent target genes
    Hongtao Chen
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Cell 149:618-29. 2012
    The homeodomain (HD) protein Bicoid (Bcd) is thought to function as a gradient morphogen that positions boundaries of target genes via threshold-dependent activation mechanisms...
  80. doi Antitumor effects of genetically engineered stem cells expressing yeast cytosine deaminase in lung cancer brain metastases via their tumor-tropic properties
    Bo Rim Yi
    Laboratory of Veterinary Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
    Oncol Rep 27:1823-8. 2012
    ..Cytosine deaminase (CD), one of the suicide genes, originating from bacterial (bCD) or yeast (yCD), which can convert the non-toxic prodrug, 5-fluorocytosine (5-FC), into 5-fluorouracil (..
  81. pmc Comparative modeling and molecular docking of orphan human CYP4V2 protein with fatty acid substrates: Insights into substrate specificity
    Suresh Kumar
    Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Coimbatore 641114, Tamil Nadu, India
    Bioinformation 7:360-5. 2011
    ..b>CYP4V2 is found to be a potential drug target for Bietti crystalline corneoretinal dystrophy (BCD)...
  82. pmc Exome sequencing identifies compound heterozygous mutations in CYP4V2 in a pedigree with retinitis pigmentosa
    Yun Wang
    Ophthalmic Laboratories and Department of Ophthalmology, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People s Republic of China
    PLoS ONE 7:e33673. 2012
    ..Compound heterozygous c.802-8_810del17insGC and c.1091-2A>G mutations of the CYP4V2 gene, known as genetic defects for Bietti crystalline corneoretinal dystrophy, were identified as causative ..
  83. pmc Host determinants of HIV-1 control in African Americans
    Kimberly Pelak
    Center for Human Genome Variation, Duke University Medical School, Durham, North Carolina, USA
    J Infect Dis 201:1141-9. 2010
    ....
  84. pmc Shaping a morphogen gradient for positional precision
    Feng He
    Division of Biomedical Informatics, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio, USA
    Biophys J 99:697-707. 2010
    ..Here, we compare the positional precision provided by the Drosophila morphogenetic protein Bicoid (Bcd) in wild-type (wt) embryos with embryos lacking an interacting cofactor...
  85. doi Low-frequency vibrational spectrum of water around cyclodextrin and its methyl-substituted derivatives
    Madhurima Jana
    Molecular Modeling Laboratory, Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India
    Langmuir 26:14097-102. 2010
    ..spectrum of water present in the surrounding hydration layers and inside the cavities of beta-cyclodextrin (BCD) and its di- and trimethyl substituted derivatives, namely, heptakis(2,6-di-O-methyl)-beta-cyclodextrin (DIMEB) and ..
  86. ncbi Trans- and cis-acting requirements for blastodermal expression of the head gap gene buttonhead
    E A Wimmer
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Mech Dev 53:235-45. 1995
    ..Expression of the btd head stripe depends on the anterior morphogen encoded by the gene bicoid (bcd)...
  87. doi Influence of supplemental dietary poultry fat, phytase, and 25-hydroxycholecalciferol on the egg characteristics of commercial layers inoculated before or at the onset of lay with F-strain Mycoplasma gallisepticum
    E D Peebles
    Department of Poultry Science, Mississippi State University, Mississippi State, MS 39762, USA
    Poult Sci 89:2078-82. 2010
    ..were administered at 12 (before lay) and 22 (onset of lay) wk and 4 dietary treatments [basal control diet (BCD); BCD with 0.75% supplemental PF; BCD with 1.50% supplemental PF; BCD with 1.50% supplemental PF, 0.013% PHY, and 0...
  88. doi Separation performance and recognition mechanism of mono(6-deoxy-imino)-beta-cyclodextrins chiral stationary phases in high-performance liquid chromatography
    Zhi Ming Zhou
    School of Chemical Engineering and the Environment, Beijing Institute of Technology, Beijing, China
    Talanta 82:775-84. 2010
    ..to form a series of imino-modified beta-cyclodextrin derivatives: mono(6-deoxy-phenylimino)-beta-cyclodextrin (BCD), mono(6-deoxy-isopropylimino)-beta-cyclodextrin (YBCD), mono(6-deoxy-N-1-phenylethylimino)-beta-cyclodextrin (R-,S-..
  89. pmc A compartmental model for the bicoid gradient
    Michail E Kavousanakis
    Department of Chemical Engineering, Princeton University, Princeton, NJ, USA
    Dev Biol 345:12-7. 2010
    ..of the Drosophila embryo is patterned by the concentration gradient of the homeodomain transcription factor bicoid (Bcd)...
  90. pmc The gap protein knirps mediates both quenching and direct repression in the Drosophila embryo
    D N Arnosti
    Department of Biology, UCSD, La Jolla 92093 0347, USA
    EMBO J 15:3659-66. 1996
    ..the knirps orphan receptor (kni) may repress transcription via competition, and exclude the binding of the bicoid (bcd) activator to an overlapping site in a target promoter...
  91. ncbi Theoretical concepts of on-line liquid chromatographic-biochemical detection systems. II. Detection systems based on labelled affinity proteins
    A J Oostercamp
    Leiden/Amsterdam Center for Drug Research, University of Leiden, The Netherlands
    J Chromatogr A 787:37-46. 1997
    A theoretical concept for on-line liquid chromatography-biochemical detection (LC-BCD) using labelled affinity proteins as reporter molecules is presented...
  92. ncbi In vivo analyses of cytoplasmic transport and cytoskeletal organization during Drosophila oogenesis: characterization of a multi-step anterior localization pathway
    W E Theurkauf
    Department of Biochemistry and Cell Biology and the Institute for Cell and Developmental Biology, State University of New York at Stony Brook, Stony Brook, NY 11794 5215, USA
    Development 125:3655-66. 1998
    Anterior patterning of the Drosophila embryo depends on localization of bicoid (bcd) mRNA to the anterior pole of the developing oocyte, and bcd mRNA localization requires both the exuperantia (exu) gene and an intact microtubule ..
  93. ncbi Preparation and in vitro, in vivo characterization of elastic liposomes encapsulating cyclodextrin-colchicine complexes for topical delivery of colchicine
    Hardevinder Pal Singh
    Department of Pharmaceutical Sciences and Drug Research, Punjabi University, India
    Yakugaku Zasshi 130:397-407. 2010
    ..Colchicine beta cyclodextrin (BCD) complex was prepared by freeze-drying method and complex formation was confirmed by NMR and in vitro drug release ..
  94. ncbi The Drosophila semushi mutation blocks nuclear import of bicoid during embryogenesis
    J L Epps
    Molecular and Cell Biology Program, University of Maryland, College Park, Maryland 20742, USA
    Curr Biol 8:1277-80. 1998
    The maternal transcript of the anterior segmentation gene bicoid (bcd) is localized at the anterior pole of the Drosophila egg and translated to form a gradient in the nuclei of the syncytial blastoderm embryo after fertilization [1-3]...
  95. ncbi Staufen protein associates with the 3'UTR of bicoid mRNA to form particles that move in a microtubule-dependent manner
    D Ferrandon
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Federal Republic of Germany
    Cell 79:1221-32. 1994
    Staufen protein is required in order to anchor bicoid (bcd) mRNA at the anterior pole of the Drosophila egg...
  96. ncbi Direct control of transcription of the Drosophila morphogen bicoid by the serendipity delta zinc finger protein, as revealed by in vivo analysis of a finger swap
    F Payre
    Centre de Biologie du Developpement, Unité Mixte de Recherche UMR 9925 du Centre National de le Recherche Scientifique CNRS, Universite Paul Sabatier, Toulouse, France
    Genes Dev 8:2718-28. 1994
    ..of the anterior structures of the Drosophila embryo is under control of the maternal gene product Bicoid (bcd), which specifies distinct domains of embryonic gene expression in a concentration-dependent manner...
  97. doi New gene variants associated with venous thrombosis: a replication study in White and Black Americans
    H Austin
    Emory University, Rollins School of Public Health, Atlanta, GA, USA
    J Thromb Haemost 9:489-95. 2011
    ..We evaluated 10 single-nucleotide polymorphisms (SNPs) identified in three European case-control studies as risk factors for venous thrombosis...
  98. ncbi Changes in the basal cell density in pig skin after single radiation doses with different dose rates
    J Nyman
    Department of Oncology, University of Gothenburg, Sahlgrenska Hospital, Sweden
    Acta Oncol 30:753-9. 1991
    Radiation-induced changes in the basal cell density (BCD) and the labelling index (LI) in the epidermis of pig skin were used to compare the effect of high and low dose rate irradiation. Single doses of 6, 12 and 24 Gy were applied at 1...
  99. doi The removal of some rare earth elements from their aqueous solutions on by-pass cement dust (BCD)
    O I M Ali
    Faculty of Science, Helwan University, Ain Helwan, Cairo, Egypt
    J Hazard Mater 195:62-7. 2011
    ..gadolinium (Gd(3+)), samarium (Sm(3+)) and lutetium (Lu(3+)) from their aqueous solutions by by-pass cement dust (BCD) has been investigated using a batch technique...
  100. ncbi bicoid mRNA localization signal: phylogenetic conservation of function and RNA secondary structure
    P M Macdonald
    Department of Biological Sciences, Stanford University, CA 94305
    Development 110:161-71. 1990
    Transcripts of the bicoid (bcd) gene are localized to the anterior pole of the Drosophila oocyte, thereby allowing formation in the embryo of an anteroposterior gradient of the bcd protein morphogen...
  101. doi Method of all-optical frequency encoded decimal to binary and binary coded decimal, binary to gray, and gray to binary data conversion using semiconductor optical amplifiers
    Sisir Kumar Garai
    Department of Physics, M U C Women s College, Burdwan, West Bengal, 713104, India
    Appl Opt 50:3795-807. 2011
    ..There are many binary code systems to represent decimal numbers, the most common being the binary coded decimal (BCD) and gray code system...

Research Grants63

  1. REGULATED MRNA TRANSLATION IN DROSOPHILA BODY PATTERNING
    Paul MacDonald; Fiscal Year: 2003
    ..The anterior morphogen of the Drosophila embryos is bicoid (bcd) and the posterior patterning is controlled by oskar (osk) and nanos (nos)...
  2. Translational repressors in Drosophila development
    Robin P Wharton; Fiscal Year: 2010
    ..Our experiments suggest that the NRE may mediate regulation of bcd mRNA during post- embryonic development, a hypothesis that will be tested in this proposal...
  3. EVC2: A novel modulator in tooth development
    Yoshiyuki Mochida; Fiscal Year: 2009
    ..A causative gene, LIMBIN for bovine chondrodysplastic dwarfism (bcd) found in Japanese brown cattle was later identified as the bovine ortholog of EVC2, indicating the significance of ..
  4. EVC2: A novel modulator in tooth development
    Yoshiyuki Mochida; Fiscal Year: 2010
    ..A causative gene, LIMBIN for bovine chondrodysplastic dwarfism (bcd) found in Japanese brown cattle was later identified as the bovine ortholog of EVC2, indicating the significance of ..
  5. Improved Suicide Gene Therapy for Hepatic Cancers
    William Ensminger; Fiscal Year: 2005
    ..compared to the previously utilized bacterial (b) CD (Aim 1) and, thus will work at FC levels lower than the bCD in gut bacteria (for lowered systemic toxicity)...
  6. Translating Dental Student Tobacco Education to Practice
    KATHLEEN RANKIN; Fiscal Year: 2007
    ..and integrated into appropriate courses throughout the 4-year dental curriculum at Baylor College of Dentistry (BCD). Full integration of the Rx for Change core curriculum will occur over a period of 3 years...
  7. MOLECULAR BIOLOGY OF MORPHOGEN LOCALIZATION IN EMBRYOS
    Paul MacDonald; Fiscal Year: 2001
    ..Thus progress here may be of general relevance to the development of all organisms. Localization of the bicoid (bcd) mRNA to the anterior pole of the oocyte is a prerequisite for the formation of an anteroposterior gradient of Bcd ..
  8. MOLECULAR BIOLOGY OF MORPHOGEN LOCALIZATION IN EMBRYOS
    Paul MacDonald; Fiscal Year: 2006
    ..The example studied here, localization of bicoid (bcd) mRNA in the Drosophila oocyte and embryo, is essential for embryonic body patterning...
  9. Engineering enzymes for anti-tumor suicide gene therapy
    Barry Stoddard; Fiscal Year: 2009
    ..a set of revised specific aims for this project as follows: (1) We will determine whether optimization of yCD or bCD leads to significant therapeutic efficacy gains via recognizable mechanisms of increased enzyme expression and/or ..
  10. Engineering enzymes for anti-tumor suicide gene therapy
    Barry L Stoddard; Fiscal Year: 2010
    ..a set of revised specific aims for this project as follows: (1) We will determine whether optimization of yCD or bCD leads to significant therapeutic efficacy gains via recognizable mechanisms of increased enzyme expression and/or ..
  11. Engineering enzymes for anti-tumor suicide gene therapy
    Barry Stoddard; Fiscal Year: 2007
    ..a set of revised specific aims for this project as follows: (1) We will determine whether optimization of yCD or bCD leads to significant therapeutic efficacy gains via recognizable mechanisms of increased enzyme expression and/or ..
  12. DENDRITIC CELLS & ACTINOBACILLUS ACTINOMYCETEMCOMITANS
    Paul Ezzo; Fiscal Year: 2004
    ..The research environment established at Baylor College of Dentistry (BCD) by Dr. Christopher Cutler, in collaboration with Dr...
  13. Mechanisms of Response and Relapse in Rituximab-treated Myositis Patients
    CHESTER V contact ODDIS; Fiscal Year: 2010
    ..One of the more novel treatments for myositis as well as other autoimmune diseases is B cell depletion (BCD) therapy with a biologic agent, rituximab...
  14. Caged micelles for co-delivery of SAHA and geldanamycin in cancer therapy
    MAY XIONG; Fiscal Year: 2007
    ..hypothesis, we propose four broad specific aims: (1) to synthesize and characterize poly(asp-g-ADA)-b-PCL and poly(bCD-PEG)-b-PCL for GAp encapsulation (caged micelle) and SAHA solubilization, respectively, and to verify the presence ..
  15. Individual Predoctoral Dental Scientist Fellowship
    JOSEPH RAWLINS; Fiscal Year: 2006
    This application proposes a graduate educational program at Baylor College of Dentistry (BCD), Texas A&M University System for Mr. Joseph T. Rawlins...
  16. STEPS CONTROLLING GENE EXPRESSION
    JUDITH LENGYEL; Fiscal Year: 1993
    ..In the anterior, a morphogen gradient, consisting of the bicoid (bcd) transcription factor, interacts with the terminal system to establish the nonsegmented acron instead of a telson...
  17. Dynamics, scaling, and precision of morphogen gradients in the Drosophila embryo
    William Bialek; Fiscal Year: 2007
    ..Our experimental system is the Bicoid (Bcd) morphogen gradient in the Drosophila embryo, the primary maternal determinant of the anterior-posterior axis...
  18. Research Infrastructure Improvement Planning Award
    David Carlson; Fiscal Year: 2003
    ..a formal strategic planning process for improvement of the research infrastructure at Baylor College of Dentistry (BCD)...
  19. Dynamics, scaling, and precision of morphogen gradients in the Drosophila embryo
    William Bialek; Fiscal Year: 2009
    ..dynamics of the formation and stabilization of the Bed gradient will be measured in living embryos expressing eGFP-Bcd. Image sequences from time-lapse two photon microscopy will be used, together with photobleaching methods and ..
  20. Bicoid: A new addition to the body plan of Drosophila
    Claude Desplan; Fiscal Year: 2003
    Although the Bicoid morphogen (Bcd) plays a pivotal role in patterning the anterior of the Drosophila (Dm) embryo, no bed homologue has been found outside Diptera...
  21. Bicoid: A new addition to the body plan of Drosophila
    Claude Desplan; Fiscal Year: 2006
    Although the Bicoid morphogen (Bcd) plays a pivotal role in patterning the anterior of the Drosophila (Dm) embryo, no bed homologue has been found outside Diptera...