CYP4V2

Summary

Gene Symbol: CYP4V2
Description: cytochrome P450 family 4 subfamily V member 2
Alias: BCD, CYP4AH1, cytochrome P450 4V2, cytochrome P450, family 4, subfamily V, polypeptide 2, docosahexaenoic acid omega-hydroxylase CYP4V2
Species: human
Products:     CYP4V2

Top Publications

  1. Shan M, Dong B, Zhao X, Wang J, Li G, Yang Y, et al. Novel mutations in the CYP4V2 gene associated with Bietti crystalline corneoretinal dystrophy. Mol Vis. 2005;11:738-43 pubmed
    ..Recently mutations in a new gene CYP4V2, encoding a protein belonging to a novel member of the cytochrome P450 family, have been identified as the cause ..
  2. Jin Z, Ito S, Saito Y, Inoue Y, Yanagi Y, Nao I N. Clinical and molecular findings in three Japanese patients with crystalline retinopathy. Jpn J Ophthalmol. 2006;50:426-431 pubmed publisher
    To identify CYP4V2 mutations in three unrelated Japanese patients with Bietti crystalline corneoretinal dystrophy (BCD). The three cases were diagnosed by ophthalmological examinations...
  3. Song Y, Mo G, Yin G. A novel mutation in the CYP4V2 gene in a Chinese patient with Bietti's crystalline dystrophy. Int Ophthalmol. 2013;33:269-76 pubmed publisher
    ..It is known that mutations in the CYP4V2 gene result in BCD...
  4. Yin H, Jin C, Fang X, Miao Q, Zhao Y, Chen Z, et al. Molecular analysis and phenotypic study in 14 Chinese families with Bietti crystalline dystrophy. PLoS ONE. 2014;9:e94960 pubmed publisher
    To investigate the clinical features and cytochrome P450 family 4 subfamily V polypeptide 2 (CYP4V2) gene mutations in 14 Chinese families with Bietti crystalline dystrophy (BCD)...
  5. Wada Y, Itabashi T, Sato H, Kawamura M, Tada A, Tamai M. Screening for mutations in CYP4V2 gene in Japanese patients with Bietti's crystalline corneoretinal dystrophy. Am J Ophthalmol. 2005;139:894-9 pubmed
    ..An identical IVS6 to 8delTCATACAGGTCATCGCG/insGC mutation in the CYP4V2 gene was identified in five of the patients with BCD; the sixth patient had a novel Trp340X mutation in the CYP4V2 ..
  6. Rossi S, Testa F, Li A, Iorio V, Zhang J, Gesualdo C, et al. An atypical form of Bietti crystalline dystrophy. Ophthalmic Genet. 2011;32:118-21 pubmed publisher
    ..The patient underwent a thorough medical anamnesis, genetic counseling, peripheral blood draw for CYP4V2 gene analysis and electron microscopy, and a complete ophthalmological assessment including optical coherence ..
  7. García García G, Lopez Garrido M, Martínez Rubio M, Moya Moya M, Belmonte Martínez J, Escribano J. Genotype-phenotype analysis of Bietti crystalline dystrophy in a family with the CYP4V2 Ile111Thr mutation. Cornea. 2013;32:1002-8 pubmed publisher
    ..Genomic DNA was obtained from blood samples, and 11 exons of the CYP4V2 gene were screened for mutations by polymerase chain reaction DNA sequencing...
  8. Jiao X, Munier F, Iwata F, Hayakawa M, Kanai A, Lee J, et al. Genetic linkage of Bietti crystallin corneoretinal dystrophy to chromosome 4q35. Am J Hum Genet. 2000;67:1309-13 pubmed
    Bietti crystalline corneoretinal dystrophy (BCD) is an autosomal recessive retinal degeneration characterized by multiple glistening intraretinal dots scattered over the fundus, degeneration of the retina, and sclerosis of the choroidal ..
  9. Gekka T, Hayashi T, Takeuchi T, Goto Omoto S, Kitahara K. CYP4V2 mutations in two Japanese patients with Bietti's crystalline dystrophy. Ophthalmic Res. 2005;37:262-9 pubmed
    ..The purpose of this study was to report mutations in the CYP4V2 gene (encoding a ubiquitously-expressed 525-amino acid sequence belonging to the CYP450 family) and to investigate ..

More Information

Publications102 found, 100 shown here

  1. Kelly E, Nakano M, Rohatgi P, Yarov Yarovoy V, Rettie A. Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states. Mol Interv. 2011;11:124-32 pubmed publisher
    ..Human CYP4V2 and CYP4F22 are two such orphan P450s that are strongly linked to ocular andskin disease, respectively...
  2. Xiao X, Mai G, Li S, Guo X, Zhang Q. Identification of CYP4V2 mutation in 21 families and overview of mutation spectrum in Bietti crystalline corneoretinal dystrophy. Biochem Biophys Res Commun. 2011;409:181-6 pubmed publisher
    ..BCD is caused by CYP4V2 mutations...
  3. Haddad N, Waked N, Bejjani R, Khoueir Z, Chouery E, Corbani S, et al. Clinical and molecular findings in three Lebanese families with Bietti crystalline dystrophy: report on a novel mutation. Mol Vis. 2012;18:1182-8 pubmed
    ..rare autosomal recessive disorder caused by mutation of the cytochrome P450, family 4, subfamily V, polypeptide 2 (CYP4V2) gene and characterized by retinal pigmentary abnormalities and scattered deposits of crystals in the retina and ..
  4. Nakamura M, Lin J, Nishiguchi K, Kondo M, Sugita J, Miyake Y. Bietti crystalline corneoretinal dystrophy associated with CYP4V2 gene mutations. Adv Exp Med Biol. 2006;572:49-53 pubmed
    ..Recent studies have demonstrated that the CYP4V2 gene which encodes a CYP450 family protein is the causative gene of the disease...
  5. Nakano M, Kelly E, Rettie A. Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase. Drug Metab Dispos. 2009;37:2119-22 pubmed publisher
    Bietti's crystalline dystrophy is an ocular disease that is strongly associated with polymorphisms in the CYP4V2 gene...
  6. Mamatha G, Umashankar V, Kasinathan N, Krishnan T, Sathyabaarathi R, Karthiyayini T, et al. Molecular screening of the CYP4V2 gene in Bietti crystalline dystrophy that is associated with choroidal neovascularization. Mol Vis. 2011;17:1970-7 pubmed
    ..The disease is caused by mutation in the cytochrome p450, family 4, subfamily v, polypeptide 2 (CYP4V2) gene. Choroidal neovascularization (CNV) is a rare event in BCD. We report two cases of BCD associated with CNV...
  7. Li A, Jiao X, Munier F, Schorderet D, Yao W, Iwata F, et al. Bietti crystalline corneoretinal dystrophy is caused by mutations in the novel gene CYP4V2. Am J Hum Genet. 2004;74:817-26 pubmed
    ..by D4S2924 by linkage and haplotype analysis; mutations were found in the novel CYP450 family member CYP4V2 in 23 of 25 unrelated patients with BCD tested...
  8. Lee K, Koh A, Aung T, Yong V, Yeung K, Ang C, et al. Characterization of Bietti crystalline dystrophy patients with CYP4V2 mutations. Invest Ophthalmol Vis Sci. 2005;46:3812-6 pubmed
    Mutations of the CYP4V2 gene, a novel family member of the cytochrome P450 genes on chromosome 4q35, have recently been identified in patients with Bietti crystalline dystrophy (BCD)...
  9. Lai T, Ng T, Tam P, Yam G, Ngai J, Chan W, et al. Genotype phenotype analysis of Bietti's crystalline dystrophy in patients with CYP4V2 mutations. Invest Ophthalmol Vis Sci. 2007;48:5212-20 pubmed
    To evaluate the genotypic and phenotypic correlations of Bietti's crystalline dystrophy (BCD) in patients with the CYP4V2 gene by mutation screening and clinical and electrophysiological assessment...
  10. Rossi S, Testa F, Li A, Yaylacioglu F, Gesualdo C, Hejtmancik J, et al. Clinical and genetic features in Italian Bietti crystalline dystrophy patients. Br J Ophthalmol. 2013;97:174-9 pubmed publisher
    ..The 11 exons of the CYP4V2 gene were sequenced...
  11. Halford S, Liew G, Mackay D, Sergouniotis P, Holt R, Broadgate S, et al. Detailed phenotypic and genotypic characterization of bietti crystalline dystrophy. Ophthalmology. 2014;121:1174-84 pubmed publisher
    ..The gene CYP4V2 was sequenced. Clinical, imaging, electrophysiologic, and molecular genetics findings...
  12. Hedman A, Zilmer M, Sundstrom J, Lind L, Ingelsson E. DNA methylation patterns associated with oxidative stress in an ageing population. BMC Med Genomics. 2016;9:72 pubmed
    ..lipoprotein (oxLDL), antibodies against oxLDL [OLAB], conjugated dienes [CD], baseline conjugated dienes [BCD]-LDL and total antioxidant capacity [TAOC]) and incident disease in up to 966 age-matched individuals...
  13. Zeneli L, Sekovanić A, Ajvazi M, Kurti L, Daci N. Alterations in antioxidant defense system of workers chronically exposed to arsenic, cadmium and mercury from coal flying ash. Environ Geochem Health. 2016;38:65-72 pubmed publisher
    ..05) between BAs/SZn (r = 0.211), BAs/BSe (r = 0.287), BCd/SCu (r = 0.32) and BHg/BSe (r = 0.263) in the plant workers...
  14. Balaban C, Rodríguez J, Tiribelli C, Guibert E. The effect of a hydrogen sulfide releasing molecule (Na2S) on the cold storage of livers from cardiac dead donor rats. A study in an ex vivo model. Cryobiology. 2015;71:24-32 pubmed publisher
    ..groups were established as follows: I--Livers procured before cardiac death and cold stored 24 h in HTK (BCD); II--Livers procured after cardiac death (45 min) and cold stored 24 h in HTK (ACD); III--Livers procured after ..
  15. Zhao G, Wang B, Liu Y, Du J, Li B, Chen Y, et al. Activation of BmGSTd1 promoter and regulation by transcription factor Krüppel (Kr) in silkworm, Bombyx mori. Gene. 2014;551:152-9 pubmed publisher
    ..Sequence analysis of this region revealed several potential transcriptional regulatory elements such as Bcd and Kr...
  16. Hu Q, Xiao H, Tian H, Meng Y. Identification and expression of cytochrome P450 genes in the Chinese giant salamander Andrias davidianus. Theriogenology. 2017;95:62-68 pubmed publisher
    ..showed multiple cyp genes to exhibit higher expression in ovary than in testis, including cyp26a, cyp19a, cyp1a1, cyp4v2, cyp3a24, cyp2c20, cyp2d14, cyp2d15, and cyp4b; while cyp11a, cyp2b11, cyp11b1, cyp4f22, cyp2j6, cyp2k1, cyp2k4, ..
  17. Eun H, Cho S, Lee B, Seong I, Kim K. Profiling cytochrome P450 family 4 gene expression in human hepatocellular carcinoma. Mol Med Rep. 2018;18:4865-4876 pubmed publisher
    ..HCC survival analyses indicated better overall survival in patients with high CYP4F2, CYP4F12 and CYP4V2 mRNA expression levels; the results for histological grade and Tumor‑Node‑Metastasis stage supported these ..
  18. Higo A, Ehira S. Anaerobic butanol production driven by oxygen-evolving photosynthesis using the heterocyst-forming multicellular cyanobacterium Anabaena sp. PCC 7120. Appl Microbiol Biotechnol. 2019;103:2441-2447 pubmed publisher
    ..A strain that expressed a highly oxygen-sensitive Bcd/EtfAB complex produced 1-butanol even under photosynthetic conditions...
  19. Chowdhury N, Klomann K, Seubert A, Buckel W. Reduction of Flavodoxin by Electron Bifurcation and Sodium Ion-dependent Reoxidation by NAD+ Catalyzed by Ferredoxin-NAD+ Reductase (Rnf). J Biol Chem. 2016;291:11993-2002 pubmed publisher
    Electron-transferring flavoprotein (Etf) and butyryl-CoA dehydrogenase (Bcd) from Acidaminococcus fermentans catalyze the endergonic reduction of ferredoxin by NADH, which is also driven by the concomitant reduction of crotonyl-CoA by ..
  20. Wasserman G, Liu X, Parvez F, Chen Y, Factor Litvak P, LoIacono N, et al. A cross-sectional study of water arsenic exposure and intellectual function in adolescence in Araihazar, Bangladesh. Environ Int. 2018;118:304-313 pubmed publisher
    ..important mixture members, supported these findings; the primary contributor of the mixture was BAs, followed by BCd. Our data indicate that the adverse consequences of As exposure on neurodevelopment observed in other cross-..
  21. Vogt K, Frenzel H, Ausili S, Hollfelder D, Wollenberg B, Snik A, et al. Improved directional hearing of children with congenital unilateral conductive hearing loss implanted with an active bone-conduction implant or an active middle ear implant. Hear Res. 2018;370:238-247 pubmed publisher
    ..The present study investigated whether intervention with an active BCD, the Bonebridge, or a middle ear implant, the Vibrant Soundbridge (VSB), affected sound-localization performance of ..
  22. Trauzeddel R, Lehman H, Trauzeddel R, Haller M, Palm Beden K, Ganser G, et al. Age dependent ultrasound B-mode findings of the elbow joint in healthy children and adolescents. Rheumatol Int. 2019;: pubmed publisher
    ..distance between the outer margin of the joint capsule and the bone surface to define the bone-capsule distance (BCD), the thickness of the joint cartilage as well as the thickness of the joint capsule...
  23. Chowdhury N, Mowafy A, Demmer J, Upadhyay V, Koelzer S, Jayamani E, et al. Studies on the mechanism of electron bifurcation catalyzed by electron transferring flavoprotein (Etf) and butyryl-CoA dehydrogenase (Bcd) of Acidaminococcus fermentans. J Biol Chem. 2014;289:5145-57 pubmed publisher
    ..The remaining non-stabilized neutral semiquinone, β-FADH(•), immediately reduces ferredoxin. Repetition of this process affords a second reduced ferredoxin and Dh-FADH(-) that converts crotonyl-CoA to butyryl-CoA. ..
  24. Fujiwara R, Shih A, Mehra S. Cross-sectional Analysis of the Relationship between Paranasal Sinus Balloon Catheter Dilations and Industry Payments among Otolaryngologists. Otolaryngol Head Neck Surg. 2017;157:880-886 pubmed publisher
    ..49 additional BCDs (95% CI, 0.32-10.63; P = .04). Conclusion Payments by manufacturers of BCD devices were associated with increased use of BCD for chronic rhinosinusitis...
  25. Rigato C, Reinfeldt S, Håkansson B, Jansson K, Hol M, Eeg Olofsson M. Audiometric Comparison Between the First Patients With the Transcutaneous Bone Conduction Implant and Matched Percutaneous Bone Anchored Hearing Device Users. Otol Neurotol. 2016;37:1381-7 pubmed publisher
    ..The most widely used BCD is the percutaneous BAHA, with a permanent skin-penetrating abutment...
  26. Chen Z, Penet M, Krishnamachary B, Banerjee S, Pomper M, Bhujwalla Z. PSMA-specific theranostic nanoplex for combination of TRAIL gene and 5-FC prodrug therapy of prostate cancer. Biomaterials. 2016;80:57-67 pubmed publisher
    ..tumor necrosis factor related apoptosis-inducing ligand (TRAIL), together with bacterial cytosine deaminase (bCD) as a prodrug enzyme...
  27. Delong T, Baker R, Reisdorph N, Reisdorph R, Powell R, Armstrong M, et al. Islet amyloid polypeptide is a target antigen for diabetogenic CD4+ T cells. Diabetes. 2011;60:2325-30 pubmed publisher
    ..2.9 in vitro and in vivo and by the existence of an IAPP-derived peptide that strongly stimulates BCD-5.2.9. IAPP is the target antigen for the diabetogenic CD4 T-cell clone BDC-5.2.9.
  28. Andersson J, Sundström J, Kurland L, Gustavsson T, Hulthe J, Elmgren A, et al. The carotid artery plaque size and echogenicity are related to different cardiovascular risk factors in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Lipids. 2009;44:397-403 pubmed publisher
    ..blood glucose levels, smoking, ApoB/A1 ratio, OxLDL, TNF alpha, HOMA insulin resistance, leucocyte count, decreased BCD-LDL and low levels of l-selectin...
  29. Oña Ruales J, Ruiz Morales Y, Wise S. Identification and quantification of seven fused aromatic rings C26H14 peri-condensed benzenoid polycyclic aromatic hydrocarbons in a complex mixture of polycyclic aromatic hydrocarbons from coal tar. J Chromatogr A. 2016;1442:83-93 pubmed publisher
    ..C26H14 PAH isomers; naphtho[1,2,3,4-ghi]perylene, dibenzo[b,ghi]perylene, dibenzo[b,pqr]perylene, naphtho[8,1,2-bcd]perylene, and dibenzo[cd,lm]perylene using a retention time comparison with authentic reference standards...
  30. Li S, Li Q, Kong Y, Wu S, Cui Q, Zhang M, et al. Specific regulation of thermosensitive lipid droplet fusion by a nuclear hormone receptor pathway. Proc Natl Acad Sci U S A. 2017;114:8841-8846 pubmed publisher
    ..Here, we report that CYP-37A1 (ortholog of human cytochrome P450 CYP4V2), EMB-8 (ortholog of human P450 oxidoreductase POR), and DAF-12 (homolog of human nuclear receptors VDR/LXR) ..
  31. Hwang C, Chang P, Wang T. Contribution of remote substrate binding energy to the enzymatic rate acceleration for 3?-hydroxysteroid dehydrogenase/carbonyl reductase. Chem Biol Interact. 2017;276:133-140 pubmed publisher
    ..Differential binding interactions of the remote BCD-ring and CD-ring of androsterone with the active site of 3?-HSD/CR contribute 8.5 and 6...
  32. Declerck P, Bakalos G, Zintzaras E, Barton B, Schreitmüller T. Monoclonal Antibody Biosimilars in Oncology: Critical Appraisal of Available Data on Switching. Clin Ther. 2018;40:798-809.e2 pubmed publisher
    ..We identified 8 switching studies with biosimilars of rituximab (CT-P10, GP2013, PF-05280586, and BCD-020) and trastuzumab (ABP 980)...
  33. Kempf H, Olmer R, Haase A, Franke A, Bolesani E, Schwanke K, et al. Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. Nat Commun. 2016;7:13602 pubmed publisher
    ..Here we show that modulating the bulk cell density (BCD: cell number per culture volume) deterministically alters anteroposterior patterning of primitive streak (PS)-like ..
  34. Cheung D, Ma J. Probing the impact of temperature on molecular events in a developmental system. Sci Rep. 2015;5:13124 pubmed publisher
    ..Here we address this question using early Drosophila embryos where the maternal gradient Bicoid (Bcd) instructs anterior-patterning (AP) patterning...
  35. Chen Y, Liu M, Chen S, Wei X. Decreased formation of branched-chain short fatty acids in Bacillus amyloliquefaciens by metabolic engineering. Biotechnol Lett. 2017;39:529-533 pubmed publisher
    To reduce the unpleasant odor during 1-deoxynojirimycin (DNJ) production, the genes of leucine dehydrogenase (bcd) and phosphate butryltransferase (ptb) were deleted from Bacillus amyloliquefaciens HZ-12, and the concentrations of ..
  36. Ragavan K, Rastogi N. β-Cyclodextrin capped graphene-magnetite nanocomposite for selective adsorption of Bisphenol-A. Carbohydr Polym. 2017;168:129-137 pubmed publisher
    Beta-cyclodextrin capped Graphene-magnetite (G-Fe3O4-BCD) nanocomposite was synthesized by ethylenediamine conjugation and used as an adsorbent for selective removal of Bisphenol-A (BPA) in water...
  37. Zhu W, Peck Y, Iqbal J, Wang D. A novel DOPA-albumin based tissue adhesive for internal medical applications. Biomaterials. 2017;147:99-115 pubmed publisher
    ..Herein, a novel mussel-inspired "BCD" tissue glue made of bovine serum albumin (BSA), citrate acid (CA) and dopamine was developed aiming at internal ..
  38. Liu D, Liu Y, Meng X, Yin Z. The characterization of functional disturbances in Chinese patients with Bietti's crystalline dystrophy at different fundus stages. Graefes Arch Clin Exp Ophthalmol. 2012;250:191-200 pubmed publisher
    ..and clinical disturbances and screen the optimal functional tests in assessing Bietti's crystalline dystrophy (BCD) patients by a cross-sectional method...
  39. Hengenius J, Gribskov M, Rundell A, Fowlkes C, Umulis D. Analysis of gap gene regulation in a 3D organism-scale model of the Drosophila melanogaster embryo. PLoS ONE. 2011;6:e26797 pubmed publisher
    ..Shortly after fertilization, maternal bicoid mRNA is translated into Bicoid (Bcd)...
  40. Dehghani C, Pritchard N, Edwards K, Russell A, Malik R, Efron N. Abnormal Anterior Corneal Morphology in Diabetes Observed Using In Vivo Laser-scanning Confocal Microscopy. Ocul Surf. 2016;14:507-514 pubmed publisher
    ..Intermediate cell density (ICD), basal cell density (BCD), anterior stromal cell density (ASCD), corneal nerve fiber density (CNFD) and nerve fiber length (CNFL) were ..
  41. Dias S, Rodriguez Garcia V, Nguyen H, Pericleous C, Isenberg D. Longer duration of B cell depletion is associated with better outcome. Rheumatology (Oxford). 2015;54:1876-81 pubmed publisher
    ..on the long-term follow-up, clinically and serologically, of 98 patients with SLE treated with B cell depletion (BCD) over a 12 year period, focusing on the duration of the depletion...
  42. Lyu B, Yang Z, Gui G, Feng Y. Optimal Resource Allocation Policies for Multi-User Backscatter Communication Systems. Sensors (Basel). 2016;16: pubmed
    ..each sub-problem can be reformulated as a biconvex problem, which is solved by a proposed block coordinate descent (BCD)-based optimization algorithm...
  43. Buser M, Scinicariello F. Cadmium, Lead, and Depressive Symptoms: Analysis of National Health and Nutrition Examination Survey 2011-2012. J Clin Psychiatry. 2017;78:e515-e521 pubmed publisher
    ..The objective of the present study is to investigate the potential association between blood cadmium (BCd) and blood lead (BPb) with current depressive symptoms in the US adult population...
  44. Kostrubiak D, Vacchi Suzzi C, Smith D, Meliker J. Blood cadmium and depressive symptoms: Confounded by cigarette smoking. Psychiatry Res. 2017;256:444-447 pubmed publisher
    Our aim was to explore the association between blood cadmium (BCd) and depressive symptoms, adjusting for pack years and blood cotinine, and also stratifying by smoking status...
  45. Austin H, De Staercke C, Lally C, Bezemer I, Rosendaal F, Hooper W. New gene variants associated with venous thrombosis: a replication study in White and Black Americans. J Thromb Haemost. 2011;9:489-95 pubmed publisher
    ..We measured plasma factor (F) XI on a subset of subjects. Among Whites, positive findings for rs13146272 in the CYP4V2 gene, for rs3087505 in the KLKB1 gene and for rs3756008 and rs2036914 in the F11 gene were found...
  46. Yamashita S, Naruko A, Nakazawa Y, Zhao L, Hayashi Y, Hirama M. Total Synthesis of Limonin. Angew Chem Int Ed Engl. 2015;54:8538-41 pubmed publisher
    ..congener of the limonoids, is now reported and features 1) a tandem radical cyclization generating the BCD ring system with the C13α configuration that is essential to the limonoids and a Robinson annulation to ..
  47. Adlowitz D, Barnard J, Biear J, Cistrone C, Owen T, Wang W, et al. Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response. PLoS ONE. 2015;10:e0128269 pubmed publisher
    ..After BCD the predominant B cell populations were memory, and residual memory B cells displayed a high fraction of CD21- and ..
  48. Monteiro A, Rocha C, Oliveira M, Gontijo S, Agudelo R, Sinisterra R, et al. Nanofibers containing tetracycline/?-cyclodextrin: Physico-chemical characterization and antimicrobial evaluation. Carbohydr Polym. 2017;156:417-426 pubmed publisher
    ..tetracycline (TCN) and the second was composed of polycaprolactone loaded with tetracycline/?-cyclodextrin (TCN:BCD)...
  49. Buda S, Tolksdorf K, Schuler E, Kuhlen R, Haas W. Establishing an ICD-10 code based SARI-surveillance in Germany - description of the system and first results from five recent influenza seasons. BMC Public Health. 2017;17:612 pubmed publisher
    ..CD) based on ICD-10 codes for discharge diagnoses of respiratory tract infections (J09 - J22): basic CD (BCD), using only primary diagnoses; sensitive CD (SCD), using primary and secondary diagnoses; timely CD (TCD), using ..
  50. Bezemer I, Bare L, Doggen C, Arellano A, Tong C, Rowland C, et al. Gene variants associated with deep vein thrombosis. JAMA. 2008;299:1306-14 pubmed publisher
    ..Additional SNPs close to one SNP in CYP4V2 were genotyped in LETS and MEGA-1. Odds ratios (ORs) for DVT were estimated by logistic regression...
  51. Li Q, Li Y, Zhang X, Xu Z, Zhu X, Ma K, et al. UTILIZATION OF FUNDUS AUTOFLUORESCENCE, SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY, AND ENHANCED DEPTH IMAGING IN THE CHARACTERIZATION OF BIETTI CRYSTALLINE DYSTROPHY IN DIFFERENT STAGES. Retina. 2015;35:2074-84 pubmed publisher
    ..Choroidal neovascularization and macular edema were exhibited with high incidence. IVS6-8del17bp/inGC of the CYP4V2 gene was the most common mutant allele...
  52. Stelzl D, Nielsen T, Hansen T, di Cagno M. β-CD-dextran polymer for efficient sequestration of cholesterol from phospholipid bilayers: Mechanistic and safe-toxicity investigations. Int J Pharm. 2015;496:896-902 pubmed publisher
    The aim of this work was to investigate the suitability of β-cyclodextrin-dextran (BCD-dextran) polymer as cholesterol sequestering agent in vitro...
  53. Jin X, Qiu S, Wu K, Jia M, Wang F, Gu C, et al. The effect of Cu(2+) chelation on the direct photolysis of oxytetracycline: A study assisted by spectroscopy analysis and DFT calculation. Environ Pollut. 2016;214:831-839 pubmed publisher
    ..The occurrence of electron transfer between BCD ring and A ring also from BCD ring to Cu was evidenced by the TD-DFT result only for the OTC-Cu complexes...
  54. Jain R. Factors affecting the variability in the observed levels of cadmium in blood and urine among former and current smokers aged 20-64 and ? 65years. Environ Sci Pollut Res Int. 2017;24:8837-8851 pubmed publisher
    ..Examination Survey for 1999-2012 were used to evaluate factors that affect observed levels of blood cadmium (BCd) and urine cadmium (UCd) among former and current smokers aged 20-64 and ?65 years...
  55. Gregor T, Bialek W, de Ruyter van Steveninck R, Tank D, Wieschaus E. Diffusion and scaling during early embryonic pattern formation. Proc Natl Acad Sci U S A. 2005;102:18403-7 pubmed
    ..In the Drosophila embryo, Bicoid (Bcd) morphogen controls cell fate along 70% of the anteroposterior axis but is translated from mRNA localized at the ..
  56. Wang Y, Guo L, Cai S, Dai M, Yang Q, Yu W, et al. Exome sequencing identifies compound heterozygous mutations in CYP4V2 in a pedigree with retinitis pigmentosa. PLoS ONE. 2012;7:e33673 pubmed publisher
    ..Compound heterozygous c.802-8_810del17insGC and c.1091-2A>G mutations of the CYP4V2 gene, known as genetic defects for Bietti crystalline corneoretinal dystrophy, were identified as causative ..
  57. Meng X, Guo H, Xu H, Li Q, Jin X, Bai Y, et al. Identification of novel CYP4V2 gene mutations in 92 Chinese families with Bietti's crystalline corneoretinal dystrophy. Mol Vis. 2014;20:1806-14 pubmed
    To characterize the spectrum of CYP4V2 gene mutations in 92 unrelated Chinese probands with Bietti's crystalline dystrophy (BCD) and to describe the molecular and clinical characteristics of four novel CYP4V2 mutations associated with BCD...
  58. Katagiri S, Hayashi T, Gekka T, Tsuneoka H. A novel homozygous CYP4V2 variant (p.S121Y) associated with a choroideremia-like phenotype. Ophthalmic Genet. 2017;38:286-287 pubmed publisher
  59. Ors S. Incidence and Classification of Chest Wall Deformities in Breast Augmentation Patients. Aesthetic Plast Surg. 2017;41:1280-1290 pubmed publisher
    ..Poland syndrome (PS) in two patients, sunken chest deformity (SCD) in three patients, barrel chest deformity (BCD) in five patients, body builder deformity (BBD) in three patients, and long upper chest wall (LCW) in three ..
  60. Yi M, Shin J, Lee S. Expression of CYP4V2 in human THP1 macrophages and its transcriptional regulation by peroxisome proliferator-activated receptor gamma. Toxicol Appl Pharmacol. 2017;330:100-106 pubmed publisher
    ..Only CYP4V2 exhibited strong expression of both mRNA and protein...
  61. Nehru K. Power analysis data set for 4-Bit MOCLA adder. Data Brief. 2018;16:122-126 pubmed publisher
    ..area of the chip and optimize the power of arithmetic circuits, this paper proposes a low power carry look-ahead BCD (Binary Coded Decimal) adder which uses a four bit MOCLA (Multiplexer and Or gate based Carry Look Ahead Adder) ..
  62. Gregor T, McGregor A, Wieschaus E. Shape and function of the Bicoid morphogen gradient in dipteran species with different sized embryos. Dev Biol. 2008;316:350-8 pubmed publisher
    ..We also found that maternal expression and anteriorly localization of proteins other than Bcd does not necessarily give rise to a gradient; eGFP produced a uniform protein distribution...
  63. Yin X, Yang L, Chen N, Cui H, Zhao L, Feng L, et al. Identification of CYP4V2 mutation in 36 Chinese families with Bietti crystalline corneoretinal dystrophy. Exp Eye Res. 2016;146:154-62 pubmed publisher
    ..It is caused by a mutation in the CYP4V2 gene...
  64. Fuerst N, Serrano L, Han G, Morgan J, Maguire A, Leroy B, et al. Detailed functional and structural phenotype of Bietti crystalline dystrophy associated with mutations in CYP4V2 complicated by choroidal neovascularization. Ophthalmic Genet. 2016;37:445-452 pubmed
    ..A 34-year-old woman with BCD and mutations in CYP4V2 (c.802-8_806del13/p...
  65. Chang N. Bubbling cell death: A hot air balloon released from the nucleus in the cold. Exp Biol Med (Maywood). 2016;241:1306-15 pubmed publisher
    ..that when temperature is lowered in the surrounding environment, apoptosis stops and bubbling cell death (BCD) occurs. The study concerns the severity of frostbite...
  66. Monteiro A, Caminhas L, Ardisson J, Paniago R, Cortes M, Sinisterra R. Magnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery. Carbohydr Polym. 2017;163:1-9 pubmed publisher
    ..of different components in the formation of more stable iron oxide magnetic nanoparticles (MNPs): ?-cyclodextrin (BCD), 2-hydroxypropyl-?-cyclodextrin (HP) and citrate anion...
  67. Fleischauer M, Böcker S. Bad Clade Deletion Supertrees: A Fast and Accurate Supertree Algorithm. Mol Biol Evol. 2017;34:2408-2421 pubmed publisher
    ..We present a novel heuristic supertree algorithm called Bad Clade Deletion (BCD) supertrees...
  68. Miyata M, Hata M, Ooto S, Ogino K, Gotoh N, Morooka S, et al. CHOROIDAL AND RETINAL ATROPHY OF BIETTI CRYSTALLINE DYSTROPHY PATIENTS WITH CYP4V2 MUTATIONS COMPARED TO RETINITIS PIGMENTOSA PATIENTS WITH EYS MUTATIONS. Retina. 2017;37:1193-1202 pubmed publisher
    ..Nine eyes of nine BCD patients with CYP4V2 mutations (BCD group) were examined...
  69. Jinda W, Taylor T, Suzuki Y, Thongnoppakhun W, Limwongse C, Lertrit P, et al. Whole Exome Sequencing in Eight Thai Patients With Leber Congenital Amaurosis Reveals Mutations in the CTNNA1 and CYP4V2 Genes. Invest Ophthalmol Vis Sci. 2017;58:2413-2420 pubmed publisher
    ..NMNAT1, and RPGRIP1), one gene responsible for syndromic LCA (ALMS1), and two IRDs-related genes (CTNNA1 and CYP4V2)...
  70. Han Y, Unal B, Jing D, THIEL P, Evans J, Liu D. Nanoscale "Quantum" Islands on Metal Substrates: Microscopy Studies and Electronic Structure Analyses. Materials (Basel). 2010;3:3965-3993 pubmed publisher
    ..We also describe these issues for Ag/5-fold i-Al-Pd-Mn and Bi/5-fold i-Al-Cu-Fe [A/BCD ternary icosohedral quasicrystals]...
  71. Liu L, Zhang B, Lin K, Zhang Y, Xu X, Huo X. Thyroid disruption and reduced mental development in children from an informal e-waste recycling area: A mediation analysis. Chemosphere. 2018;193:498-505 pubmed publisher
    ..FT3, FT4, TSH, lead (BPb) and cadmium (BCd) in blood were determined, and cognitive and language scores of children were assessed based on the Bayley Scales ..
  72. Dong G, Huang L, Wu X, Wang C, Liu Y, Liu G, et al. Effect and mechanism analysis of MnO2 on permeable reactive barrier (PRB) system for the removal of tetracycline. Chemosphere. 2018;193:702-710 pubmed publisher
    ..spectrum demonstrated that A ring of TC was the main reaction site for interaction with Fe3+ and the BCD rings were crucial for interactions with MnO2...
  73. Gaucher D, Saleh M, Sauer A, Bourcier T, Speeg Schatz C. Spectral OCT analysis in Bietti crystalline dystrophy. Eur J Ophthalmol. 2010;20:612-4 pubmed
    To report the analysis of the cornea and the macular retina using both time domain (TD-OCT) and Fourier domain optical coherence tomography (FD-OCT) in a case of Bietti crystalline dystrophy (BCD).
  74. Yu R, Li D, Du X, Xia S, Liu C, Shi G. Comparative transcriptome analysis reveals key cadmium transport-related genes in roots of two pak choi (Brassica rapa L. ssp. chinensis) cultivars. BMC Genomics. 2017;18:587 pubmed publisher
    ..A total of 244,190 unigenes were obtained. Of them, 6827 DEGs, including BCd10 vs. BCd0 (690), KCd10 vs. KCd0 (2733), KCd0 vs...
  75. Park Y, Hwang D, Seong M, Park S, Woo S. Bietti Crystalline Retinopathy Confirmed by Mutation of CYP4V2 Gene in a Korean Patient. Korean J Ophthalmol. 2016;30:81-3 pubmed publisher
  76. Wang S, Dong S, Wang Y. Enhancement of solvent production by overexpressing key genes of the acetone-butanol-ethanol fermentation pathway in Clostridium saccharoperbutylacetonicum N1-4. Bioresour Technol. 2017;245:426-433 pubmed publisher
    ..adhE1D485G, thl, thlA1V5A, thlAV5A and the expression cassette EC (thl-hbd-crt-bcd) were overexpressed in C...
  77. Fu D, Ma J. Interplay between positive and negative activities that influence the role of Bicoid in transcription. Nucleic Acids Res. 2005;33:3985-93 pubmed
    The Drosophila mophogenetic protein Bicoid (Bcd) can activate transcription in a concentration-dependent manner in embryos. It contains a self-inhibitory domain that can interact with the co-repressor Sin3A...
  78. Chung J, Shin J, Jeon B, Ki C, Park T. Optical coherence tomographic findings of crystal deposits in the lens and cornea in Bietti crystalline corneoretinopathy associated with mutation in the CYP4V2 gene. Jpn J Ophthalmol. 2013;57:447-50 pubmed publisher
    ..A 49-year-old man showing typical chorioretinal degeneration with a CYP4V2 mutation was diagnosed with BCD...
  79. Cai X, Akber M, Spirov A, Baumgartner S. Cortical movement of Bicoid in early Drosophila embryos is actin- and microtubule-dependent and disagrees with the SDD diffusion model. PLoS ONE. 2017;12:e0185443 pubmed publisher
    The Bicoid (Bcd) protein gradient in Drosophila serves as a paradigm for gradient formation in textbooks. The SDD model (synthesis, diffusion, degradation) was proposed to explain the formation of the gradient...
  80. Yokoi Y, Nakazawa M, Mizukoshi S, Sato K, Usui T, Takeuchi K. Crystal deposits on the lens capsules in Bietti crystalline corneoretinal dystrophy associated with a mutation in the CYP4V2 gene. Acta Ophthalmol. 2010;88:607-9 pubmed publisher
    ..This patient is one of four (Cases 1-4) in whom we have found BCD associated with the same mutation in the CYP4V2 gene. We present a case report with molecular diagnosis...
  81. Bakke S, Aune M, Niyonzima N, Pilely K, Ryan L, Skjelland M, et al. Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation. J Immunol. 2017;199:2910-2920 pubmed publisher
    ..Cyclic oligosaccharide 2-hydroxypropyl-?-cyclodextrin (BCD) is a compound that solubilizes lipophilic substances...
  82. de Oliveira J, Sobrinho Junior I, Chahad Ehlers S, de Brito R. Evolutionary coincidence of adaptive changes in exuperantia and the emergence of bicoid in Cyclorrhapha (Diptera). Dev Genes Evol. 2017;227:355-365 pubmed publisher
    ..During Drosophila oogenesis, exuperantia (exu) is critical for localizing bicoid (bcd) messenger RNA (mRNA) to the anterior region of the oocyte...
  83. Tsui F, Ye Y, Ruiz V, Cooper G, Wagner M. Automated influenza case detection for public health surveillance and clinical diagnosis using dynamic influenza prevalence method. J Public Health (Oxf). 2017;:1-8 pubmed publisher
    To assess the performance of a Bayesian case detector (BCD) for influenza surveillance and clinical diagnosis.
  84. Miyata M, Ooto S, Ogino K, Gotoh N, Morooka S, Makiyama Y, et al. Evaluation of Photoreceptors in Bietti Crystalline Dystrophy with CYP4V2 Mutations Using Adaptive Optics Scanning Laser Ophthalmoscopy. Am J Ophthalmol. 2016;161:196-205.e1 pubmed publisher
    To evaluate photoreceptors in Bietti crystalline dystrophy patients with CYP4V2 mutations using high-resolution images of the macula obtained with adaptive optics scanning laser ophthalmoscopy (AO-SLO)...
  85. Dou Y, Chen Y, Zhang X, Xu X, Chen Y, Guo J, et al. Non-proinflammatory and responsive nanoplatforms for targeted treatment of atherosclerosis. Biomaterials. 2017;143:93-108 pubmed publisher
    ..To demonstrate this hypothesis, an acid-labile material of acetalated β-cyclodextrin (β-CD) (Ac-bCD) and a ROS-sensitive β-CD material (Ox-bCD) were separately synthesized by chemical modification of β-CD, ..
  86. Carvalho L, Burusco K, Jaime C, Venâncio T, Carvalho A, Murgas L, et al. Complexes between methyltestosterone and β-cyclodextrin for application in aquaculture production. Carbohydr Polym. 2018;179:386-393 pubmed publisher
    The inclusion complexes between 17-α-methyltestosterone (MT) and β-cyclodextrin (bCD) were prepared and characterized in dissolution and solid phase. The complex promoted a sixfold increment in solubility of the hormone...
  87. Demmer J, Pal Chowdhury N, Selmer T, Ermler U, Buckel W. The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile. Nat Commun. 2017;8:1577 pubmed publisher
    The electron transferring flavoprotein/butyryl-CoA dehydrogenase (EtfAB/Bcd) catalyzes the reduction of one crotonyl-CoA and two ferredoxins by two NADH within a flavin-based electron-bifurcating process...
  88. Tregouet D, Heath S, Saut N, Biron Andreani C, Schved J, Pernod G, et al. Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach. Blood. 2009;113:5298-303 pubmed publisher
    ..However, using this large cohort of subjects, we were able to replicate the mild effects of 2 nonsynonymous SNPs, rs1613662 in GP6 and rs13146272 in CYP4V2, recently suspected to be associated with VTE.
  89. Pelak K, Goldstein D, Walley N, Fellay J, Ge D, Shianna K, et al. Host determinants of HIV-1 control in African Americans. J Infect Dis. 2010;201:1141-9 pubmed publisher
  90. Feng S, Hu Y, Peng S, Han S, Tao H, Zhang Q, et al. Nanoparticles responsive to the inflammatory microenvironment for targeted treatment of arterial restenosis. Biomaterials. 2016;105:167-184 pubmed publisher
    ..To this end, an acetalated ?-cyclodextrin (?-CD) material (Ac-bCD) was synthesized as a pH-responsive carrier material, while a ROS-responsive material (Ox-bCD) was produced by ..
  91. Lockhart C, Smith T, Yang P, Naidu M, Rettie A, Nath A, et al. Longitudinal characterisation of function and structure of Bietti crystalline dystrophy: report on a novel homozygous mutation in CYP4V2. Br J Ophthalmol. 2018;102:187-194 pubmed publisher
    ..In 2004, mutations in the CYP4V2 gene were identified as the cause of BCD...