CYP3A7

Summary

Gene Symbol: CYP3A7
Description: cytochrome P450 family 3 subfamily A member 7
Alias: CP37, CYPIIIA7, P-450(HFL33), P-450111A7, P450-HFLA, cytochrome P450 3A7, aryl hydrocarbon hydroxylase, cytochrome P450, family 3, subfamily A, polypeptide 7, cytochrome P450, subfamily IIIA, polypeptide 7, cytochrome P450-HFLA, flavoprotein-linked monooxygenase, microsomal monooxygenase, xenobiotic monooxygenase
Species: human
Products:     CYP3A7

Top Publications

  1. Chen Y, Zhang J, Zhu P, Tan X, Lin Q, Wang W, et al. Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-hydroxylation is an In Vitro Marker of CYP3A7 Activity. Drug Metab Dispos. 2019;: pubmed publisher
    ..With none or trace contributions from CYP3A5, CYP3A7 favors the oxidations at C-19, C-4β, C-6α, C-3β and C-1β, whereas CYP3A4 favors the oxidations at C-5β and C-..
  2. Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, et al. Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. Pharmacogenetics. 2001;11:111-21 pubmed
    ..The 231 kb locus sequence contains the three CYP3A genes described previously (CYP3A4, CYP3A5 and CYP3A7), three pseudogenes as well as a novel CYP3A gene termed CYP3A43...
  3. . Continuum of Host-Gut Microbial Co-metabolism: Host CYP3A4/3A7 are Responsible for Tertiary Oxidations of Deoxycholate Species. Drug Metab Dispos. 2019;47:283-294 pubmed publisher
    ..Metabolic inhibition assays in human liver microsomes and recombinant P450 assays revealed that CYP3A4 and CYP3A7 were responsible for the regioselective oxidations of both DCA and its conjugated forms, glycodeoxycholate (GDCA) ..
  4. Lamba V, Panetta J, Strom S, Schuetz E. Genetic predictors of interindividual variability in hepatic CYP3A4 expression. J Pharmacol Exp Ther. 2010;332:1088-99 pubmed publisher
    ..white donors (n = 128) by quantitative real-time polymerase chain reaction for expression of CYP3A4, CYP3A5, and CYP3A7 and nine transcriptional regulators, coactivators, and corepressors...
  5. Aquilino M, Sánchez Argüello P, Novo M, Martínez Guitarte J. Effects on tadpole snail gene expression after exposure to vinclozolin. Ecotoxicol Environ Saf. 2019;170:568-577 pubmed publisher
    ..available data, permitted the identification of several genes related to detoxification mechanisms (Cyp2u1, Cyp3a7, Cyp4f22, GSTo1, GSTt2, and MRP1), stress response (Hsp20.4, Hsp17, Hsp16...
  6. Hao W, Zhang Y, Xie Y, Guo B, Chang J, Li J, et al. Myclobutanil accumulation, transcriptional alteration, and tissue injury in lizards (Eremias argus) treated with myclobutanil enantiomers. Ecotoxicol Environ Saf. 2019;171:247-255 pubmed publisher
    ..responses of metabolic enzyme genes indicated that cytochrome P450 1a1 (cyp1a1), cyp2d3, cyp2d6, cyp3a4 and cyp3a7 played a crucial role in the metabolism of (+)-myclobutanil, whereas cyp1a1, cyp2d3, cyp2d6, cyp2c8, and cyp3a4 ..
  7. Hyland P, Freedman N, Hu N, Tang Z, Wang L, Wang C, et al. Genetic variants in sex hormone metabolic pathway genes and risk of esophageal squamous cell carcinoma. Carcinogenesis. 2013;34:1062-8 pubmed publisher
    ..15 and estrogen removal: P = 0.19) with risk of ESCC. However, six individual genes (including SULT2B1, CYP1B1, CYP3A7, CYP3A5, SHBG and CYP11A1) were significantly associated with ESCC risk (P < 0.05)...
  8. Vyhlidal C, Pearce R, Gaedigk R, Calamia J, Shuster D, Thummel K, et al. Variability in Expression of CYP3A5 in Human Fetal Liver. Drug Metab Dispos. 2015;43:1286-93 pubmed publisher
    ..enzymes exhibit developmental changes in expression in human liver characterized by a transition between CYP3A7 and CYP3A4 over the first few years of life...
  9. Yablokov E, Florinskaya A, Medvedev A, Sergeev G, Strushkevich N, Luschik A, et al. Thermodynamics of interactions between mammalian cytochromes P450 and b5. Arch Biochem Biophys. 2017;619:10-15 pubmed publisher
    ..Being a crucial component of the microsomal monooxygenase system, CYPs are involved in numerous protein-protein interactions...

More Information

Publications133 found, 100 shown here

  1. Deng J, Zhao L, Zhang N, Karrow N, Krumm C, Qi D, et al. Aflatoxin B1 metabolism: Regulation by phase I and II metabolizing enzymes and chemoprotective agents. Mutat Res. 2018;778:79-89 pubmed publisher
    ..In humans, cytochrome P450 (CYP) 1A2, CYP3A4, CYP3A5, and CYP3A7 in liver and CYP2A13 in lung are essential for the bioactivation of AFB1 to the extremely toxic exo-AFB<..
  2. Nibourg G, Huisman M, van der Hoeven T, van Gulik T, Chamuleau R, Hoekstra R. Stable overexpression of pregnane X receptor in HepG2 cells increases its potential for bioartificial liver application. Liver Transpl. 2010;16:1075-85 pubmed publisher
    ..Upon activation of PXR by rifampicin, the messenger RNA levels of CYP3A4, CYP3A5, and CYP3A7 increased 49- to 213-fold versus HepG2 cells...
  3. Goldstein I, Rivlin N, Shoshana O, Ezra O, Madar S, Goldfinger N, et al. Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53. Carcinogenesis. 2013;34:190-8 pubmed publisher
    ..liver cells, we found a group of eleven P450 genes whose expression was induced by p53 (CYP3A4, CYP3A43, CYP3A5, CYP3A7, CYP4F2, CYP4F3, CYP4F11, CYP4F12, CYP19A1, CYP21A2 and CYP24A1)...
  4. Sohn M, Kim M, Han N, Kim I, Gim J, Min S, et al. Whole exome sequencing for the identification of CYP3A7 variants associated with tacrolimus concentrations in kidney transplant patients. Sci Rep. 2018;8:18064 pubmed publisher
    ..Tacrolimus C0/D was log-transformed. Sixteen variants were identified including novel CYP3A7 rs12360 and rs10211 by ANOVA...
  5. Hasegawa M, Kapelyukh Y, Tahara H, Seibler J, Rode A, Krueger S, et al. Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line. Mol Pharmacol. 2011;80:518-28 pubmed publisher
    ..receptor, and a replacement of the mouse Cyp3a cluster with a large human genomic region carrying CYP3A4 and CYP3A7. We provide evidence that this model shows a human-like CYP3A4 induction response to different PXR activators, ..
  6. Fang J, Song J. In vitro characterization of the oxidation of a pyridinium metabolite of haloperidol by human placenta: the effect of smoking. J Pharm Pharm Sci. 2012;15:538-47 pubmed
    ..This seems to indicate important contributions of CYP1A1 and CYP3A7 as compared to CYP1A2 and CYP3A4, respectively, because furafylline and ketokonazole are stronger inhibitors of ..
  7. Stockmann C, Fassl B, Gaedigk R, Nkoy F, Uchida D, Monson S, et al. Fluticasone propionate pharmacogenetics: CYP3A4*22 polymorphism and pediatric asthma control. J Pediatr. 2013;162:1222-7, 1227.e1-2 pubmed publisher
    ..in drug metabolism was assessed by genotyping 9 single nucleotide polymorphisms in the CYP3A4, CYP3A5, and CYP3A7 genes...
  8. Patil P, Begum S, Joshi M, Kleman M, Olausson M, Sumitran Holgersson S. Phenotypic and in vivo functional characterization of immortalized human fetal liver cells. Scand J Gastroenterol. 2014;49:705-14 pubmed publisher
    ..The cells did not stain for any of the tested cancer-associated markers. Albumin, HNF-4α and CYP3A7 expression was confirmed by reverse transcription polymerase chain reaction (RT-PCR)...
  9. Cohen I, Cirulli E, Mitchell M, Jönsson T, Yu J, Shah N, et al. Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones. EBioMedicine. 2018;28:316-323 pubmed publisher
    ..Although CYP3A7-CYP3A51P variants also modified levels of some sulfated sex hormones, only acetaminophen use phenocopied the ..
  10. Li X, Zuo Y, Qin L, Liu W, Li Y, Li J. Atrazine-xenobiotic nuclear receptor interactions induce cardiac inflammation and endoplasmic reticulum stress in quail (Coturnix coturnix coturnix). Chemosphere. 2018;206:549-559 pubmed publisher
    ..system (APND, ERND, AH, and NCR) activities and the expression of CYP isoforms (CYP1B1, CYP2C18, CYP2D6, CYP3A4, CYP3A7, and CYP4B1) in quail heart...
  11. Rodriguez Antona C, Axelson M, Otter C, Rane A, Ingelman Sundberg M. A novel polymorphic cytochrome P450 formed by splicing of CYP3A7 and the pseudogene CYP3AP1. J Biol Chem. 2005;280:28324-31 pubmed
    The cytochrome P450 3A7 (CYP3A7) is the most abundant CYP in human liver during fetal development and first months of postnatal age, playing an important role in the metabolism of endogenous hormones, drugs, differentiation factors, and ..
  12. Elens L, Capron A, Kerckhove V, Lerut J, Mourad M, Lison D, et al. 1199G>A and 2677G>T/A polymorphisms of ABCB1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation. Pharmacogenet Genomics. 2007;17:873-83 pubmed
    ..aim of our study was to investigate the effect of genetic polymorphisms in biotransformation enzymes (CYP3A5 and CYP3A7) or in their regulatory protein pregnane X receptor as well as in transporter proteins (ABCB1 and OATP-C) on Tac ..
  13. Komori M, Nishio K, Fujitani T, Ohi H, Kitada M, Mima S, et al. Isolation of a new human fetal liver cytochrome P450 cDNA clone: evidence for expression of a limited number of forms of cytochrome P450 in human fetal livers. Arch Biochem Biophys. 1989;272:219-25 pubmed
    From a human fetal liver cDNA library, a new cDNA clone (lambda HFL10) was isolated using an antiserum to P450 HFLa, which has been isolated from livers of human fetuses...
  14. Ren X, Pan L, Wang L. The detoxification process, bioaccumulation and damage effect in juvenile white shrimp Litopenaeus vannamei exposed to chrysene. Ecotoxicol Environ Saf. 2015;114:44-51 pubmed publisher
    ..The activities of aryl hydrocarbon hydroxylase (AHH), 7-ethoxyresorufin O-deethylase (EROD), epoxide hydrolase (EH), glutathione-S-transferase (GST), ..
  15. Yu T, Wang X, Zhu G, Han C, Su H, Liao X, et al. The prognostic value of differentially expressed CYP3A subfamily members for hepatocellular carcinoma. Cancer Manag Res. 2018;10:1713-1726 pubmed publisher
    The activities of four cytochrome P3A (CYP3A) subfamily members (CYP3A4, CYP3A5, CYP3A7, and CYP3A43) are well documented in drug metabolism...
  16. Itoh S, Yanagimoto T, Tagawa S, Hashimoto H, Kitamura R, Nakajima Y, et al. Genomic organization of human fetal specific P-450IIIA7 (cytochrome P-450HFLa)-related gene(s) and interaction of transcriptional regulatory factor with its DNA element in the 5' flanking region. Biochim Biophys Acta. 1992;1130:133-8 pubmed
    ..Among them, it was shown that a basic transcription element binding factor (BTEB) actually interacted with the 5' flanking region of this gene. ..
  17. Lacroix D, Sonnier M, Moncion A, Cheron G, Cresteil T. Expression of CYP3A in the human liver--evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth. Eur J Biochem. 1997;247:625-34 pubmed
    ..Two members of the CYP3A subfamily display developmentally regulated expression in the liver; CYP3A7 is expressed in the fetal liver, whereas CYP3A4 is the major cyrochrome P-450 isoform present in the adult liver...
  18. Godamudunage M, Grech A, Scott E. Comparison of Antifungal Azole Interactions with Adult Cytochrome P450 3A4 versus Neonatal Cytochrome P450 3A7. Drug Metab Dispos. 2018;46:1329-1337 pubmed publisher
    ..In the fetal and neonatal stages of life, the 87% identical cytochrome P450 3A7 (CYP3A7) is expressed but not CYP3A4...
  19. Sim S, Edwards R, Boobis A, Ingelman Sundberg M. CYP3A7 protein expression is high in a fraction of adult human livers and partially associated with the CYP3A7*1C allele. Pharmacogenet Genomics. 2005;15:625-31 pubmed
    Previously, cytochrome P450 3A7 (CYP3A7), which constitutes the major CYP enzyme in fetal livers, has been considered a fetus-specific enzyme...
  20. Shuster D, Risler L, Prasad B, Calamia J, Voellinger J, Kelly E, et al. Identification of CYP3A7 for glyburide metabolism in human fetal livers. Biochem Pharmacol. 2014;92:690-700 pubmed publisher
    ..CYP3A4 had the highest metabolic capacity towards glyburide, followed by CYP3A7 and CYP3A5 (Clint,u=37.1, 13.0, and 8.7ml/min/nmol P450, respectively)...
  21. Zia H, Murray G, Vyhlidal C, Leeder J, Anwar A, Bui M, et al. CYP3A isoforms in Ewing's sarcoma tumours: an immunohistochemical study with clinical correlation. Int J Exp Pathol. 2015;96:81-6 pubmed publisher
    ..Tissue microarrays slides were processed for immunohistochemical labelling for CYP3A4, CYP3A5 and CYP3A7 using liver sections as positive control...
  22. Takahiro R, Nakamura S, Kohno H, Yoshimura N, Nakamura T, Ozawa S, et al. Contribution of CYP3A isoforms to dealkylation of PDE5 inhibitors: a comparison between sildenafil N-demethylation and tadalafil demethylenation. Biol Pharm Bull. 2015;38:58-65 pubmed publisher
    ..formation of the phosphodiesterase type-5 (PDE5) inhibitors sildenafil and tadalafil by CYP3A4, CYP3A5, and CYP3A7 isoforms...
  23. Wu Y, Chitranshi P, Loukotková L, Gamboa da Costa G, Beland F, Zhang J, et al. Cytochrome P450-mediated metabolism of triclosan attenuates its cytotoxicity in hepatic cells. Arch Toxicol. 2017;91:2405-2423 pubmed publisher
    ..CYP1A2, CYP1B1, CYP2A6, CYP2A7, CYP2A13, CYP2B6, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A5, CYP3A7, CYP4A11, and CYP4B1...
  24. Ramirez J, Innocenti F, Schuetz E, Flockhart D, Relling M, Santucci R, et al. CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes. Drug Metab Dispos. 2004;32:930-6 pubmed
    ..We conclude that normeperidine formation in human liver microsomes is mainly catalyzed by CYP2B6 and CYP3A4, with a minor contribution from CYP2C19. ..
  25. Oneda B, Crettol S, Jaquenoud Sirot E, Bochud M, Ansermot N, Eap C. The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test. Pharmacogenet Genomics. 2009;19:877-83 pubmed publisher
    CYP3A4, CYP3A5 and CYP3A7 are hepatic enzymes that metabolize about 50% of drugs on the market, with a large overlap in their specificities. We investigated the genetic bases that contribute to the variation of CYP3A activity...
  26. Pang X, Cheng J, Kim J, Matsubara T, Krausz K, Gonzalez F. Expression and regulation of human fetal-specific CYP3A7 in mice. Endocrinology. 2012;153:1453-63 pubmed publisher
    b>CYP3A7 is the predominant cytochrome P450 (CYP) expressed in human fetal liver, accounting for 30-50% of the total CYP in fetal liver and 87-100% of total fetal hepatic CYP3A content...
  27. Choo E, Woolsey S, DeMent K, Ly J, Messick K, Qin A, et al. Use of transgenic mouse models to understand the oral disposition and drug-drug interaction potential of cobimetinib, a MEK inhibitor. Drug Metab Dispos. 2015;43:864-9 pubmed publisher
    ..inhibition and induction on cobimetinib exposures was tested in the Cyp3a(-/-)Tg-3A4Hep/Int and PXR-CAR-CYP3A4/CYP3A7 mouse models, respectively. After i.v...
  28. Chen S, Wu Q, Ning B, Bryant M, Guo L. The role of hepatic cytochrome P450s in the cytotoxicity of dronedarone. Arch Toxicol. 2018;92:1969-1981 pubmed publisher
    ..We demonstrated that CYP3A4, 3A5, and 2D6 were the major enzymes that metabolize dronedarone, and that CYP3A7, 2E1, 2C19, 2C18, 1A1, and 2B6 also metabolize dronedarone, but to a lesser extent...
  29. Smutny T, Harjumäki R, Kanninen L, Yliperttula M, Pavek P, Lou Y. A feasibility study of the toxic responses of human induced pluripotent stem cell-derived hepatocytes to phytochemicals. Toxicol In Vitro. 2018;52:94-105 pubmed publisher
    ..B did not exhibit toxic effect on the iHep and HepG2 cells when compared with LTHHs, it decreased CYP3A7 expression in the iHep cells and increased CYP1A2 expression in HepG2 cells...
  30. Masuyama H, Hiramatsu Y, Kodama J, Kudo T. Expression and potential roles of pregnane X receptor in endometrial cancer. J Clin Endocrinol Metab. 2003;88:4446-54 pubmed
  31. Liu Y, Wu Y, Yu Y, Cao C, Zhang J, Li K, et al. Curcumin and resveratrol in combination modulate drug-metabolizing enzymes as well as antioxidant indices during lung carcinogenesis in mice. Hum Exp Toxicol. 2015;34:620-7 pubmed publisher
    ..Further, BP treatment also resulted in a significant increase in the enzyme activities of aryl hydrocarbon hydroxylase as well as drug-metabolizing enzymes, namely cytocrome P450 and cytochrome b5...
  32. Qu Z, Li D, Xu H, Zhang R, Li B, Sun C, et al.  CUL4B, NEDD4, and UGT1As involve in the TGF-? signalling in hepatocellular carcinoma. Ann Hepatol. 2016;15:568-76 pubmed
    ..Besides, the 11 pathways in TF-pathway-DEG network were mainly enriched by UGT1A family and CYP3A7, which were predicted to be regulated by SMAD2, SMAD3, SOX2, TP63, and HNF4A...
  33. Ueyama T, Tsuji S, Sugiyama T, Tada M. Fluorometric evaluation of CYP3A4 expression using improved transgenic HepaRG cells carrying a dual-colour reporter for CYP3A4 and CYP3A7. Sci Rep. 2017;7:2874 pubmed publisher
    ..cells carrying a dual reporter that express red fluorescent protein (RFP) under the transcriptional regulation of CYP3A7 in the hepatoblast-like cell state and enhanced green fluorescent protein (EGFP) under the transcriptional ..
  34. Trescot A, Faynboym S. A review of the role of genetic testing in pain medicine. Pain Physician. 2014;17:425-45 pubmed
    ..the specific pain implications of genetic variations in CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A7, OPRM1, OPRK1, OPRD1, COMT, GABA, UGT, MC1R, GCH1, ABCB1, P-glycoprotein, 5HTR1A, 5HTR2A, MTHFR, CACNA2D2, and 5-..
  35. Xiu M, Pan L, Jin Q. Toxic effects upon exposure to polycyclic aromatic hydrocarbon (chrysene) in scallop Chlamys farreri during the reproduction period. Environ Toxicol Pharmacol. 2016;44:75-83 pubmed publisher
    ..At days 1, 3, 6, 10, 11, 15 and 21, aryl hydrocarbon hydroxylase (AHH), 7-ethoxyresorufin-O-deethylase (EROD), glutathione-s-transferase (GST), glutathione (GSH), ..
  36. Gota V, Chinnaswamy G, Vora T, Rath S, Yadav A, Gurjar M, et al. Pharmacokinetics and pharmacogenetics of 13-cis retinoic acid in Indian high-risk neuroblastoma patients. Cancer Chemother Pharmacol. 2016;78:763-8 pubmed publisher
    ..Patients were genotyped for UGT2B7, CYP3A5*3, CYP3A7*2 and *2, *3 and *4 variants of CYP2C8. Marked inter-patient variability in 13-cisRA pharmacokinetics was observed...
  37. Saheli M, Sepantafar M, Pournasr B, Farzaneh Z, Vosough M, Piryaei A, et al. Three-Dimensional Liver-derived Extracellular Matrix Hydrogel Promotes Liver Organoids Function. J Cell Biochem. 2017;: pubmed publisher
    ..The LEMgel organoid had significant upregulation of transcripts of ALB, CYP3A4, CYP3A7, and TAT as well as downregulation of AFP compared to collagen type I- and hydrogel-free-organoids or organoids in ..
  38. Tebbens J, Azar M, Friedmann E, Lanzendörfer M, Pavek P. Mathematical Models in the Description of Pregnane X Receptor (PXR)-Regulated Cytochrome P450 Enzyme Induction. Int J Mol Sci. 2018;19: pubmed publisher
    ..both in basal and/or inducible expression of many other CYPs, such as CYP2B6, CYP2C8, 2C9 and 2C19, CYP3A5, CYP3A7, and CYP2A6...
  39. Jones D, Kim S, Boysen G, Yun C, Miller G. Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin. Drug Metab Lett. 2010;4:213-9 pubmed
    ..Despite a significant focus on CYP3A4, little is known about CYP3A5 and CYP3A7 metabolism of warfarin...
  40. Cartularo L, Laulicht F, Sun H, Kluz T, Freedman J, Costa M. Gene expression and pathway analysis of human hepatocellular carcinoma cells treated with cadmium. Toxicol Appl Pharmacol. 2015;288:399-408 pubmed publisher
    ..Downregulated genes included the monooxygenase CYP3A7, involved in drug and lipid metabolism...
  41. Cui Y, Tian X, Ning J, Wang C, Yu Z, Wang Y, et al. Metabolic Profile of 3-Acetyl-11-Keto-β-Boswellic Acid and 11-Keto-β-Boswellic Acid in Human Preparations In Vitro, Species Differences, and Bioactivity Variation. AAPS J. 2016;18:1273-88 pubmed publisher
    ..Although CYP3A4, CYP3A5, and CYP3A7 catalyzed the metabolism of KBA, CYP3A4 played a predominant role in the hydroxylation reaction of KBA in human...
  42. Hines R. The ontogeny of drug metabolism enzymes and implications for adverse drug events. Pharmacol Ther. 2008;118:250-67 pubmed publisher
    ..Some enzymes, e.g., CYP3A7, are expressed at their highest level during the first trimester and either remain at high concentrations or ..
  43. Maezawa K, Matsunaga T, Takezawa T, Kanai M, Ohira S, Ohmori S. Cytochrome P450 3As gene expression and testosterone 6 beta-hydroxylase activity in human fetal membranes and placenta at full term. Biol Pharm Bull. 2010;33:249-54 pubmed
    Expression levels of cytochrome P450 (CYP) 3A4, CYP3A5 and CYP3A7 mRNAs in placentas and fetal membranes, which were split into amnion and chorion leave attached decidua (chorion/decidua), obtained from pregnant women with normal delivery ..
  44. Chen H, Fantel A, Juchau M. Catalysis of the 4-hydroxylation of retinoic acids by cyp3a7 in human fetal hepatic tissues. Drug Metab Dispos. 2000;28:1051-7 pubmed
    Cytochrome P4503A7 (CYP3A7) is the primary CYP isoform expressed in human fetal hepatic microsomes, and its potential role in human embryotoxicity has attracted considerable investigative attention...
  45. Suzuki E, Matsunaga T, Aonuma A, Sasaki T, Nagata K, Ohmori S. Effects of hypoxia-inducible factor-1α chemical stabilizer, CoCl(2) and hypoxia on gene expression of CYP3As in human fetal liver cells. Drug Metab Pharmacokinet. 2012;27:398-404 pubmed
    Distinctive response patterns of CYP3A4 and CYP3A7 to cobalt chloride (CoCl(2)) in human fetal liver (HFL) cells were observed and compared with those under hypoxic conditions...
  46. Krusekopf S, Roots I, Kleeberg U. Differential drug-induced mRNA expression of human CYP3A4 compared to CYP3A5, CYP3A7 and CYP3A43. Eur J Pharmacol. 2003;466:7-12 pubmed
    ..CYP3A4 was the only CYP3A isoform that was induced by all of the four benzimidazole derivatives, while CYP3A5, CYP3A7, and CYP3A43 were unaffected or even slightly downregulated by these drugs. St...
  47. Lee A, Cai M, Thomas P, Conney A, Zhu B. Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003;144:3382-98 pubmed
    ..b>CYP3A7 had a distinct catalytic activity for the 16alpha-hydroxylation of estrone, but not 17beta-estradiol...
  48. Foster B, Cvijovic K, Boon H, Tam T, Liu R, Murty M, et al. Melatonin Interaction Resulting in Severe Sedation. J Pharm Pharm Sci. 2015;18:124-31 pubmed
    ..In vitro analysis involving several melatonin products showed product-dependent inhibition of CYP1A2, CYP2C19 and CYP3A7. The adverse event was likely due to a primary pharmacokinetic interaction between melatonin and citalopram; ..
  49. Vyhlidal C, Bi C, Ye S, Leeder J. Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers. Drug Metab Dispos. 2016;44:1020-6 pubmed publisher
    Members of the human CYP3A family of metabolizing enzymes exhibit developmental changes in expression whereby CYP3A7 is expressed in fetal tissues, followed by a transition to expression of CYP3A4 in the first months of life...
  50. Chang J, Chen J, Liu L, Messick K, Ly J. Rifampin-Mediated Induction of Tamoxifen Metabolism in a Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse Model. Drug Metab Dispos. 2016;44:1736-1741 pubmed
    ..transgenic mouse model expressing human pregnane X receptor (PXR), constitutive androstane receptor (CAR), CYP3A4/CYP3A7, and CYP2D6 (Tg-composite) was used to investigate the effect of induction mediated by rifampin on the ..
  51. Nishimura M, Ueda N, Naito S. Effects of dimethyl sulfoxide on the gene induction of cytochrome P450 isoforms, UGT-dependent glucuronosyl transferase isoforms, and ABCB1 in primary culture of human hepatocytes. Biol Pharm Bull. 2003;26:1052-6 pubmed
    ..gene expression of GAPDH, cytochrome P450 isoforms (CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2E1, CYP3A4, CYP3A5, and CYP3A7), UGT-dependent glucuronosyl transferase isoforms (UGT1A6 and UGT1A9), and ABC transporter (ABCB1) after exposure ..
  52. Neunzig I, Dragan C, Widjaja M, Schwaninger A, Peters F, Maurer H, et al. Whole-cell biotransformation assay for investigation of the human drug metabolizing enzyme CYP3A7. Biochim Biophys Acta. 2011;1814:161-7 pubmed publisher
    The cytochrome P450 isoform CYP3A7 (wildtype) is the major form of CYP in human fetal liver...
  53. Wang B, Jakus A, Baptista P, Soker S, Soto Gutierrez A, Abecassis M, et al. Functional Maturation of Induced Pluripotent Stem Cell Hepatocytes in Extracellular Matrix-A Comparative Analysis of Bioartificial Liver Microenvironments. Stem Cells Transl Med. 2016;5:1257-67 pubmed publisher
    ..the level of primary cryopreserved hepatocytes with lower transcription of fetal-specific genes, ?-fetoprotein and CYP3A7, compared with either PLLA-collagen scaffolds or sandwich culture...
  54. Abe S, Kobayashi K, Oji A, Sakuma T, Kazuki K, Takehara S, et al. Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology. Sci Rep. 2017;7:15189 pubmed publisher
    ..we developed fully humanized transchromosomic (Tc) CYP3A mice with the CYP3A cluster including CYP3A4, CYP3A5, CYP3A7, and CYP3A43. Our humanized CYP3A mice have the CYP3A5*3 (g...
  55. Jounaidi Y, Guzelian P, Maurel P, Vilarem M. Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7. Biochem Biophys Res Commun. 1994;205:1741-7 pubmed
    Two genomic clones containing the 3'-end of CYP3A7, the whole 5'-flanking region plus the first exon of CYP3A5 were isolated from two different human genomic banks and sequenced...
  56. Goodarzi M, Xu N, Azziz R. Association of CYP3A7*1C and serum dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2008;93:2909-12 pubmed publisher
    Adrenal androgen excess is common in polycystic ovary syndrome (PCOS) and appears to be heritable. CYP3A7 metabolizes dehydroepiandrosterone and its sulfate (DHEAS)...
  57. Tateishi T, Watanabe M, Moriya H, Yamaguchi S, Sato T, Kobayashi S. No ethnic difference between Caucasian and Japanese hepatic samples in the expression frequency of CYP3A5 and CYP3A7 proteins. Biochem Pharmacol. 1999;57:935-9 pubmed
    Ethnic differences in the pharmacokinetics of nifedipine, a substrate of CYP3A, and in CYP3A7 expression have been reported...
  58. Bahari A, Mehrzad J, Mahmoudi M, Bassami M, Dehghani H. Cytochrome P450 isoforms are differently up-regulated in aflatoxin B?-exposed human lymphocytes and monocytes. Immunopharmacol Immunotoxicol. 2014;36:1-10 pubmed publisher
    ..Only CYP1A1, CYP1B1, CYP3A4, CYP3A5 and CYP3A7 expressed in lymphocytes and monocytes...
  59. Bacsi K, Kosa J, Borgulya G, Balla B, Lazary A, Nagy Z, et al. CYP3A7*1C polymorphism, serum dehydroepiandrosterone sulfate level, and bone mineral density in postmenopausal women. Calcif Tissue Int. 2007;80:154-9 pubmed
    The CYP3A7 enzyme metabolizes some steroid hormones, including dehydroepiandrosterone sulfate (DHEAS). The age-related decline of serum DHEAS levels is believed to contribute to osteoporosis...
  60. Smith G, Stubbins M, Harries L, Wolf C. Molecular genetics of the human cytochrome P450 monooxygenase superfamily. Xenobiotica. 1998;28:1129-65 pubmed
  61. Nakamura H, Torimoto N, Ishii I, Ariyoshi N, Nakasa H, Ohmori S, et al. CYP3A4 and CYP3A7-mediated carbamazepine 10,11-epoxidation are activated by differential endogenous steroids. Drug Metab Dispos. 2003;31:432-8 pubmed
    ..investigated the effects of endogenous steroids on the activity of CBZ 10,11-epoxidation by expressed CYP3A4 and CYP3A7. When expressed CYP3A4 was used as an enzyme source, the addition of AND to the reaction mixture also caused a ..
  62. Stevens J. New perspectives on the impact of cytochrome P450 3A expression for pediatric pharmacology. Drug Discov Today. 2006;11:440-5 pubmed
    ..These concepts are exemplified by the three major human cytochrome P450 (CYP) 3A enzymes: CYP3A4, CYP3A5 and CYP3A7. Recent preclinical and clinical studies show CYP3A7 is the most abundant CYP3A enzyme in fetal liver, with a ..
  63. Komori M, Nishio K, Kitada M, Shiramatsu K, Muroya K, Soma M, et al. Fetus-specific expression of a form of cytochrome P-450 in human livers. Biochemistry. 1990;29:4430-3 pubmed
    ..These results indicate that P-450(HFL33) is expressed specifically in fetal livers and that neither P-450NF nor HLp is expressed in fetal livers, but one or both are expressed in adult livers. ..
  64. Schuetz J, Kauma S, Guzelian P. Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta. J Clin Invest. 1993;92:1018-24 pubmed
    ..We found an immunoreactive 51,500 D protein that migrated between CYP3A3 (HLp) and CYP3A5 (HLp2) identical with CYP3A7 (HFLa)...
  65. Lamba J, Lin Y, Schuetz E, Thummel K. Genetic contribution to variable human CYP3A-mediated metabolism. Adv Drug Deliv Rev. 2002;54:1271-94 pubmed
    ..g., lung, kidney, prostate, breast, leukocytes). CYP3A7 is considered to be the major fetal liver CYP3A enzyme...
  66. Yamaori S, Yamazaki H, Suzuki A, Yamada A, Tani H, Kamidate T, et al. Effects of cytochrome b(5) on drug oxidation activities of human cytochrome P450 (CYP) 3As: similarity of CYP3A5 with CYP3A4 but not CYP3A7. Biochem Pharmacol. 2003;66:2333-40 pubmed
    Effects of cytochrome b(5) (b(5)) on catalytic activities of human cytochrome P450 (CYP) 3A5, CYP3A4, and CYP3A7 coexpressed with human NADPH-cytochrome P450 reductase in Escherichia coli membranes were investigated using 14 substrates...
  67. Raunio H, Hakkola J, Pelkonen O. Regulation of CYP3A genes in the human respiratory tract. Chem Biol Interact. 2005;151:53-62 pubmed
    The CYP3A gene cluster consists of four members, CYP3A4, CYP3A5, CYP3A7 and CYP3A43...
  68. Du J, Yu L, Wang L, Zhang A, Shu A, Xu L, et al. Differences in CYP3A41G genotype distribution and haplotypes of CYP3A4, CYP3A5 and CYP3A7 in 3 Chinese populations. Clin Chim Acta. 2007;383:172-4 pubmed
  69. Niwa T, Murayama N, Yamazaki H. Heterotropic cooperativity in oxidation mediated by cytochrome p450. Curr Drug Metab. 2008;9:453-62 pubmed
    ..studies have been shown that human P450 forms other than CYP3A4, such as CYP1A2, CYP2C8, CYP2C9, CYP2D6, and CYP3A7, are also activated by some compounds, whereas there are few reports on CYP3A5...
  70. Zordoky B, El Kadi A. Role of NF-kappaB in the regulation of cytochrome P450 enzymes. Curr Drug Metab. 2009;10:164-78 pubmed
    ..First, NF-kappaB can directly regulate the expression of CYP1A1, CYP2B1/2, CYP2C11, CYP2D5, CYP2E1, CYP3A7, and CYP27B1 through binding to the promoter region of these genes...
  71. Dumond J, Vourvahis M, Rezk N, Patterson K, Tien H, White N, et al. A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir. Clin Pharmacol Ther. 2010;87:735-42 pubmed publisher
    ..Although mixed induction and inhibition are present, this approach offers an understanding of drug interaction mechanisms and ultimately assists in optimizing the clinical use of TPV/r. ..
  72. Betts S, Björkhem Bergman L, Rane A, Ekström L. Expression of CYP3A4 and CYP3A7 in Human Foetal Tissues and its Correlation with Nuclear Receptors. Basic Clin Pharmacol Toxicol. 2015;117:261-6 pubmed publisher
    ..The aim of this study was to investigate the gene expression of CYP3A4 and the foetal CYP3A7 in human foetal tissues and their relation to gene expression and genetic variations in the nuclear receptors VDR, ..
  73. Li X, Zhou Y, Zhou S, Liu H, Xu J, Gao L, et al. Histopathology of melanosis coli and determination of its associated genes by comparative analysis of expression microarrays. Mol Med Rep. 2015;12:5807-15 pubmed publisher
    ..Expression microarray analysis revealed that the significantly downregulated genes were CYP3A4, CYP3A7, UGT2B11 and UGT2B15 in melanosis coli...
  74. Hakkola J, Raunio H, Purkunen R, Pelkonen O, Saarikoski S, Cresteil T, et al. Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy. Biochem Pharmacol. 1996;52:379-83 pubmed
    ..mRNAs of CYP1A1, CYP1A2, CYP2C, CYP2D6, CYP2E1, CYP2F1, CYP3A4, CYP3A5, CYP3A7, and CYP4B1 were identified by reverse transcriptase-polymearse chain reaction (RT-PCR) in at least some of the ..
  75. Greuet J, Pichard L, Bonfils C, Domergue J, Maurel P. The fetal specific gene CYP3A7 is inducible by rifampicin in adult human hepatocytes in primary culture. Biochem Biophys Res Commun. 1996;225:689-94 pubmed
    We investigated by RNase protection the differential expression of CYP3A4 and CYP3A7 mRNAs in fetal and adult human livers and in adult hepatocytes in primary culture...
  76. Ohmori S, Fujiki N, Nakasa H, Nakamura H, Ishii I, Itahashi K, et al. Steroid hydroxylation by human fetal CYP3A7 and human NADPH-cytochrome P450 reductase coexpressed in insect cells using baculovirus. Res Commun Mol Pathol Pharmacol. 1998;100:15-28 pubmed
    Human fetal CYP3A7 and human NADPH-cytochrome P450 reductase were coexpressed in insect cells, TN-5, infected with a recombinant baculovirus carrying both cDNAs...
  77. Inoue E, Takahashi Y, Imai Y, Kamataki T. Development of bacterial expression system with high yield of CYP3A7, a human fetus-specific form of cytochrome P450. Biochem Biophys Res Commun. 2000;269:623-7 pubmed
    In an E. coli expression system for human cytochrome P450 3A7 (CYP3A7), holo-CYP3A7 was not expressed as judged by CO-difference spectra, although apo-CYP3A7 was clearly detected by Western blot analysis...
  78. Finta C, Zaphiropoulos P. The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons. Gene. 2000;260:13-23 pubmed
    ..we have mapped the human cytochrome P450 3A (CYP3A) locus containing the genes encoding for CYP3A4, CYP3A5 and CYP3A7. The genes lie in a head-to-tail orientation in the order of 3A4, 3A7 and 3A5...
  79. Gerhold D, Lu M, Xu J, Austin C, Caskey C, Rushmore T. Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays. Physiol Genomics. 2001;5:161-70 pubmed
    ..Oligonucleotides representing human cytochrome P-450 gene CYP3A5 showed heterologous hybridization to CYP3A4 and CYP3A7 RNAs...
  80. Lee A, Conney A, Zhu B. Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol. Cancer Res. 2003;63:6532-6 pubmed
    ..We report here our novel findings that human CYP3A7 has a distinct high catalytic activity for the NADPH-dependent 16alpha-hydroxylation of estrone (E(1); at 10 nM to ..
  81. Du J, Shi Y, Zhang A, Wang L, Xuan J, He G, et al. Screening for SNPs and haplotypes in the CYP3A7 gene in Chinese populations. Pharmacogenomics. 2007;8:559-66 pubmed
    ..SNP analyses of the CYP3A7 gene were carried out on three groups of healthy Chinese subjects consisting of 539 Han, 264 She and 273 Dong ..
  82. Elens L, Yombi J, Lison D, Wallemacq P, Vandercam B, Haufroid V. Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients. Pharmacogenomics. 2009;10:1589-97 pubmed publisher
    ..Further investigations are needed to confirm this association and to explore its real pharmacodynamic impact. ..
  83. Sood D, Johnson N, Jain P, Siskos A, Bennett M, Gilham C, et al. CYP3A7*1C allele is associated with reduced levels of 2-hydroxylation pathway oestrogen metabolites. Br J Cancer. 2017;116:382-388 pubmed publisher
    ..We have previously identified a CYP3A7*1C allele that is associated with lower urinary oestrone (E1) levels in premenopausal women...
  84. Ourlin J, Jounaidi Y, Maurel P, Vilarem M. Role of the liver-enriched transcription factors C/EBP alpha and DBP in the expression of human CYP3A4 and CYP3A7. J Hepatol. 1997;26 Suppl 2:54-62 pubmed
    In the human fetal liver, CYP3A7 is expressed as early as the 13th week of gestation. This continues to the perinatal period when it is sharply repressed prior to birth...
  85. Pascussi J, Jounaidi Y, Drocourt L, Domergue J, Balabaud C, Maurel P, et al. Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene. Biochem Biophys Res Commun. 1999;260:377-81 pubmed
    ..In this work we have isolated and sequenced the proximal 5'-flanking region of CYP3A7 from two different human genomic libraries. In contrast to a previously reported sequence (Itoh et al...
  86. Yamaori S, Yamazaki H, Iwano S, Kiyotani K, Matsumura K, Saito T, et al. Ethnic differences between Japanese and Caucasians in the expression levels of mRNAs for CYP3A4, CYP3A5 and CYP3A7: lack of co-regulation of the expression of CYP3A in Japanese livers. Xenobiotica. 2005;35:69-83 pubmed
    ..real-time reverse transcriptase-polymerase chain reaction method, mRNAs were quantitated for CYP3A4, CYP3A5 and CYP3A7 in adult livers from 24 Japanese and 24 Caucasian subjects to elucidate the potential ethnic differences in the ..
  87. Smit P, van Schaik R, van der Werf M, van den Beld A, Koper J, Lindemans J, et al. A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels. J Clin Endocrinol Metab. 2005;90:5313-6 pubmed
    b>CYP3A7, expressed in the human fetal liver and normally silenced after birth, plays a major role in the 16alpha-hydroxylation of dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), and estrone...
  88. Qiu H, Taudien S, Herlyn H, Schmitz J, Zhou Y, Chen G, et al. CYP3 phylogenomics: evidence for positive selection of CYP3A4 and CYP3A7. Pharmacogenet Genomics. 2008;18:53-66 pubmed publisher
    ..recent episodes of particularly strong positive selection acting on primate CYP3A protein-coding sequence: (i) on CYP3A7 early in hominoid evolution, which was accompanied by a restriction of its hepatic expression to fetal period and (..
  89. . Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. Breast Cancer Res Treat. 2010;119:463-74 pubmed publisher
    ..Twenty-eight polymorphisms in eight genes of phase I (CYP1A1, CYP1A2, CYP1B1, CYP2C9, CYP2C19, CYP3A4, CYP3A5, CYP3A7) and nine genes of phase II enzymes (COMT, GSTM1, GSTM3, GSTP1, GSTT1, SULT1A1, UGT1A1, UGT1A6, UGT2B7) were ..
  90. Jaquenoud Sirot E, Knezevic B, Morena G, Harenberg S, Oneda B, Crettol S, et al. ABCB1 and cytochrome P450 polymorphisms: clinical pharmacogenetics of clozapine. J Clin Psychopharmacol. 2009;29:319-26 pubmed publisher
    ..In addition, ABCB1, but not CYP2B6, CYP2C9, CYP2D6, CYP3A5, nor CYP3A7 polymorphisms, influence clozapine pharmacokinetics.
  91. Siemes C, Visser L, de Jong F, Coebergh J, Uitterlinden A, Hofman A, et al. Cytochrome P450 3A gene variation, steroid hormone serum levels and prostate cancer--The Rotterdam Study. Steroids. 2010;75:1024-32 pubmed publisher
    ..CYP3A5 A-allele carriage was associated with increased levels of estrone sulphate (p=0.02). CYP3A7 G-allele carriage was associated with the highest number of significant differences in steroid hormone levels...
  92. Salameh G, Al Hadidi K, El Khateeb M. Genetic polymorphisms of the CYP3A4, CYP3A5, CYP3A7 and CYP1A2 among the Jordanian population. Environ Toxicol Pharmacol. 2012;34:23-33 pubmed publisher
    ..The objective of this study was to find the allelic frequencies of CYP3A5*2,*3,*4,*5,*6,*7, CYP3A4*1B, CYP3A7*1C and CYP1A2*1C, *1D, *1E, *1F enzymes in Jordanians, and to compare them with other ethnic groups...