CYP2J2

Summary

Gene Symbol: CYP2J2
Description: cytochrome P450 family 2 subfamily J member 2
Alias: CPJ2, CYPIIJ2, cytochrome P450 2J2, arachidonic acid epoxygenase, cytochrome P450, family 2, subfamily J, polypeptide 2, cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2, flavoprotein-linked monooxygenase, microsomal monooxygenase
Species: human
Products:     CYP2J2

Top Publications

  1. Jiang J, Ning Y, Chen C, Ma D, Liu Z, Yang S, et al. Cytochrome p450 epoxygenase promotes human cancer metastasis. Cancer Res. 2007;67:6665-74 pubmed
    ..We previously reported that the CYP2J2 epoxygenase is overexpressed in human cancer tissues and cancer cell lines and that EETs enhance tumor growth, ..
  2. Chen C, Wei X, Rao X, Wu J, Yang S, Chen F, et al. Cytochrome P450 2J2 is highly expressed in hematologic malignant diseases and promotes tumor cell growth. J Pharmacol Exp Ther. 2011;336:344-55 pubmed publisher
    b>Cytochrome P450 2J2 (CYP2J2) epoxygenase converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs) that exert multiple biological effects in the cardiovascular system and in various human solid cancers...
  3. Liu P, Li Y, Chao T, Wu H, Lin L, Tsai L, et al. Synergistic effect of cytochrome P450 epoxygenase CYP2J2*7 polymorphism with smoking on the onset of premature myocardial infarction. Atherosclerosis. 2007;195:199-206 pubmed
    ..We aimed to elucidate the relationship between the functional CYP2J2*7 polymorphism and smoking for the onset of premature myocardial infarction (MI)...
  4. Spiecker M, Darius H, Hankeln T, Soufi M, Sattler A, Schaefer J, et al. Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2. Circulation. 2004;110:2132-6 pubmed
    ..However, it is not known whether genetic polymorphisms of CYP2J2 are associated with increased cardiovascular risks...
  5. Capdevila J, Falck J, Harris R. Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res. 2000;41:163-81 pubmed
  6. Ma J, Ramachandran S, Fiedorek F, Zeldin D. Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4. Genomics. 1998;49:152-5 pubmed
    ..The corresponding human CYP2J gene (CYP2J2) has been assigned to human chromosome 1 on a panel of somatic hybrid cell lines and to 1p31.3-p31...
  7. Wu S, Moomaw C, Tomer K, Falck J, Zeldin D. Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. J Biol Chem. 1996;271:3460-8 pubmed
    A cDNA encoding a human cytochrome P450 arachidonic acid epoxygenase was isolated from a human liver cDNA library...
  8. Zeldin D, Foley J, Ma J, Boyle J, Pascual J, Moomaw C, et al. CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance. Mol Pharmacol. 1996;50:1111-7 pubmed
    ..We recently described a new human P450 arachidonic acid epoxygenase (CYP2J2) and the corresponding rat homologue (CYP2J3)...
  9. Bystrom J, Wray J, Sugden M, Holness M, Swales K, Warner T, et al. Endogenous epoxygenases are modulators of monocyte/macrophage activity. PLoS ONE. 2011;6:e26591 pubmed publisher
    ..When transfected in vitro, CYP2J2 is an efficient activator of anti-inflammatory pathways through the nuclear receptor peroxisome proliferator-..
  10. Deng Y, Edin M, Theken K, Schuck R, Flake G, Kannon M, et al. Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice. FASEB J. 2011;25:703-13 pubmed publisher
    ..acute vascular inflammatory responses to endotoxin in transgenic mice with endothelial expression of the human CYP2J2 and CYP2C8 epoxygenases and mice with targeted disruption of Ephx2...

Detail Information

Publications85

  1. Jiang J, Ning Y, Chen C, Ma D, Liu Z, Yang S, et al. Cytochrome p450 epoxygenase promotes human cancer metastasis. Cancer Res. 2007;67:6665-74 pubmed
    ..We previously reported that the CYP2J2 epoxygenase is overexpressed in human cancer tissues and cancer cell lines and that EETs enhance tumor growth, ..
  2. Chen C, Wei X, Rao X, Wu J, Yang S, Chen F, et al. Cytochrome P450 2J2 is highly expressed in hematologic malignant diseases and promotes tumor cell growth. J Pharmacol Exp Ther. 2011;336:344-55 pubmed publisher
    b>Cytochrome P450 2J2 (CYP2J2) epoxygenase converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs) that exert multiple biological effects in the cardiovascular system and in various human solid cancers...
  3. Liu P, Li Y, Chao T, Wu H, Lin L, Tsai L, et al. Synergistic effect of cytochrome P450 epoxygenase CYP2J2*7 polymorphism with smoking on the onset of premature myocardial infarction. Atherosclerosis. 2007;195:199-206 pubmed
    ..We aimed to elucidate the relationship between the functional CYP2J2*7 polymorphism and smoking for the onset of premature myocardial infarction (MI)...
  4. Spiecker M, Darius H, Hankeln T, Soufi M, Sattler A, Schaefer J, et al. Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2. Circulation. 2004;110:2132-6 pubmed
    ..However, it is not known whether genetic polymorphisms of CYP2J2 are associated with increased cardiovascular risks...
  5. Capdevila J, Falck J, Harris R. Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res. 2000;41:163-81 pubmed
  6. Ma J, Ramachandran S, Fiedorek F, Zeldin D. Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4. Genomics. 1998;49:152-5 pubmed
    ..The corresponding human CYP2J gene (CYP2J2) has been assigned to human chromosome 1 on a panel of somatic hybrid cell lines and to 1p31.3-p31...
  7. Wu S, Moomaw C, Tomer K, Falck J, Zeldin D. Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. J Biol Chem. 1996;271:3460-8 pubmed
    A cDNA encoding a human cytochrome P450 arachidonic acid epoxygenase was isolated from a human liver cDNA library...
  8. Zeldin D, Foley J, Ma J, Boyle J, Pascual J, Moomaw C, et al. CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance. Mol Pharmacol. 1996;50:1111-7 pubmed
    ..We recently described a new human P450 arachidonic acid epoxygenase (CYP2J2) and the corresponding rat homologue (CYP2J3)...
  9. Bystrom J, Wray J, Sugden M, Holness M, Swales K, Warner T, et al. Endogenous epoxygenases are modulators of monocyte/macrophage activity. PLoS ONE. 2011;6:e26591 pubmed publisher
    ..When transfected in vitro, CYP2J2 is an efficient activator of anti-inflammatory pathways through the nuclear receptor peroxisome proliferator-..
  10. Deng Y, Edin M, Theken K, Schuck R, Flake G, Kannon M, et al. Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice. FASEB J. 2011;25:703-13 pubmed publisher
    ..acute vascular inflammatory responses to endotoxin in transgenic mice with endothelial expression of the human CYP2J2 and CYP2C8 epoxygenases and mice with targeted disruption of Ephx2...
  11. Herse F, LaMarca B, Hubel C, Kaartokallio T, Lokki A, Ekholm E, et al. Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia. Circulation. 2012;126:2990-9 pubmed publisher
    ..The CYP subfamily 2J polypeptide 2 (CYP2J2) was upregulated in preeclamptic placenta and decidua...
  12. Wray J, Sugden M, Zeldin D, Greenwood G, Samsuddin S, Miller DeGraff L, et al. The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo. PLoS ONE. 2009;4:e7421 pubmed publisher
    ..However, little is known regarding the endogenous generation of PPAR ligands. CYP2J2 is a lipid metabolising cytochrome P450, which produces anti-inflammatory mediators, and is considered the major ..
  13. Chen F, Chen C, Yang S, Gong W, Wang Y, Cianflone K, et al. Let-7b inhibits human cancer phenotype by targeting cytochrome P450 epoxygenase 2J2. PLoS ONE. 2012;7:e39197 pubmed publisher
    ..Increasing data implicate altered miRNA participation in the progress of cancer. We previously reported that CYP2J2 epoxygenase promotes human cancer phenotypes. But whether and how CYP2J2 is regulated by miRNA is not understood...
  14. Nakayama K, Nitto T, Inoue T, Node K. Expression of the cytochrome P450 epoxygenase CYP2J2 in human monocytic leukocytes. Life Sci. 2008;83:339-45 pubmed publisher
    b>CYP2J2 is one of the cytochrome P450 epoxygenases involved in the metabolism of arachidonic acid. CYP2J2 has been identified in several tissues, especially cardiovascular tissues...
  15. Lafite P, Dijols S, Zeldin D, Dansette P, Mansuy D. Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2. Arch Biochem Biophys. 2007;464:155-68 pubmed
    ..drugs terfenadine and ebastine have been designed, synthesized and evaluated as inhibitors of recombinant human CYP2J2. Compound 14, which has an imidazole substituent, is a good non-competitive inhibitor of CYP2J2 (IC(50)=400nM)...
  16. Lee C, North K, Bray M, Couper D, Heiss G, Zeldin D. CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study. Pharmacogenet Genomics. 2007;17:349-58 pubmed
    The cytochromes P450 epoxygenases CYP2J2 and CYP2C8 synthesize epoxyeicosatrienoic acids, which regulate endothelial function...
  17. Hoffmann M, Bugert P, Seelhorst U, Wellnitz B, Winkelmann B, Boehm B, et al. The -50G>T polymorphism in the promoter of the CYP2J2 gene in coronary heart disease: the Ludwigshafen Risk and Cardiovascular Health study. Clin Chem. 2007;53:539-40 pubmed
  18. Seubert J, Yang B, Bradbury J, Graves J, Degraff L, Gabel S, et al. Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. Circ Res. 2004;95:506-14 pubmed
    Human CYP2J2 is abundant in heart and active in the biosynthesis of epoxyeicosatrienoic acids (EETs); however, the functional role of this P450 and its eicosanoid products in the heart remains unknown...
  19. Enayetallah A, French R, Grant D. Distribution of soluble epoxide hydrolase, cytochrome P450 2C8, 2C9 and 2J2 in human malignant neoplasms. J Mol Histol. 2006;37:133-41 pubmed
    ..Our study warrants further investigation of the role of altered expression of these enzymes in neoplastic tissues. ..
  20. Xiao Y, Ke Q, Seubert J, Bradbury J, Graves J, Degraff L, et al. Enhancement of cardiac L-type Ca2+ currents in transgenic mice with cardiac-specific overexpression of CYP2J2. Mol Pharmacol. 2004;66:1607-16 pubmed
    b>CYP2J2 is abundant in cardiomyocytes and is involved in the metabolism of arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs), which affect multiple cell functions...
  21. Ho M, Ring N, Amaral K, Doshi U, Li A. Human Enterocytes as an In Vitro Model for the Evaluation of Intestinal Drug Metabolism: Characterization of Drug-Metabolizing Enzyme Activities of Cryopreserved Human Enterocytes from Twenty-Four Donors. Drug Metab Dispos. 2017;45:686-691 pubmed publisher
    ..chlorzoxazone 6-hydroxylation), CYP3A4 (midazolam 1'-hydroxylation and testosterone 6β-hydroxylation), CYP2J2 (astemizole O-demethylation), UDP-glucuronosyltransferase (UGT; 7-hydroxycoumarin glucuronidation), ..
  22. Phuc N, Wu Z, O Y, Lee J, Oh S, Song G, et al. LKY-047: First Selective Inhibitor of Cytochrome P450 2J2. Drug Metab Dispos. 2017;45:765-769 pubmed publisher
    Highly selective cytochrome P450 CYP2J2 (CYP2J2) inhibitors suitable for reaction phenotyping are currently not available...
  23. Wei X, Zhang D, Dou X, Niu N, Huang W, Bai J, et al. Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer. BMC Cancer. 2014;14:841 pubmed publisher
    ..Furthermore, CYP2C8 and 2C9 protein levels positively correlated with Ki67 status, and CYP2J2 levels positively correlated with histological grade and tumor size...
  24. Arnold W, Baylon J, Tajkhorshid E, Das A. Arachidonic Acid Metabolism by Human Cardiovascular CYP2J2 is Modulated by Doxorubicin. Biochemistry. 2017;: pubmed publisher
    ..However, it causes cardiotoxicity partly due to the formation of reactive oxygen species (ROS). CYP2J2 is a human cytochrome P450 that is highly expressed in cardiomyocytes...
  25. Askari A, Thomson S, Edin M, Zeldin D, Bishop Bailey D. Roles of the epoxygenase CYP2J2 in the endothelium. Prostaglandins Other Lipid Mediat. 2013;107:56-63 pubmed publisher
    ..b>CYP2J2 is highly expressed in cardiovascular tissue including the heart and vascular endothelial cells...
  26. Theken K, Lee C. Genetic variation in the cytochrome P450 epoxygenase pathway and cardiovascular disease risk. Pharmacogenomics. 2007;8:1369-83 pubmed
    ..may significantly modulate epoxyeicosatrienoic acid levels in vivo, have been identified in the genes encoding CYP2J2, CYP2C8, CYP2C9 and soluble epoxide hydrolase...
  27. Sisignano M, Angioni C, Park C, Meyer dos Santos S, Jordan H, Kuzikov M, et al. Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain. Proc Natl Acad Sci U S A. 2016;113:12544-12549 pubmed
    ..In a drug repurposing screen targeting CYP2J2, the human ortholog of murine CYP2J6, we identified telmisartan, a widely used angiotensin II receptor antagonist, ..
  28. King L, Gainer J, David G, Dai D, Goldstein J, Brown N, et al. Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension. Pharmacogenet Genomics. 2005;15:7-13 pubmed
    b>CYP2J2 and CYP2C8 metabolize arachidonic acid (AA) to cis-epoxyeicosatrienoic acids (EETs), which play a central role in regulating renal tubular fluid-electrolyte transport and vascular tone...
  29. Bystrom J, Thomson S, Johansson J, Edin M, Zeldin D, Gilroy D, et al. Inducible CYP2J2 and its product 11,12-EET promotes bacterial phagocytosis: a role for CYP2J2 deficiency in the pathogenesis of Crohn's disease?. PLoS ONE. 2013;8:e75107 pubmed publisher
    The epoxygenase CYP2J2 has an emerging role in inflammation and vascular biology. The role of CYP2J2 in phagocytosis is not known and its regulation in human inflammatory diseases is poorly understood...
  30. Zeldin D, Foley J, Goldsworthy S, Cook M, Boyle J, Ma J, et al. CYP2J subfamily cytochrome P450s in the gastrointestinal tract: expression, localization, and potential functional significance. Mol Pharmacol. 1997;51:931-43 pubmed
    Our laboratory recently described a new human cytochrome P450 arachidonic acid epoxygenase (CYP2J2) and the corresponding rat homologue (CYP2J3), both of which were expressed in extrahepatic tissues...
  31. Arnold W, Baylon J, Tajkhorshid E, Das A. Asymmetric Binding and Metabolism of Polyunsaturated Fatty Acids (PUFAs) by CYP2J2 Epoxygenase. Biochemistry. 2016;55:6969-6980 pubmed
    ..detailed thermodynamic and kinetic analyses to determine how DHA, LA, and EPA modulate the metabolism of AA by CYP2J2. We use the Nanodisc system to stabilize CYP2J2 and its redox partner, CYP reductase (CPR)...
  32. Yao M, Lv D, Huo J, Sun Z. Cerebral Small Vessel Disease is Associated with Genetic Variations in CYP2J. Curr Neurovasc Res. 2017;: pubmed publisher
    ..Furthermore, studies have demonstrated that CYP2J2 isoform, 50 G>T variant, is associated with increase the risk of ischemic stroke...
  33. Qiu Y, Qin J, Luo Y, Qin S, Mu Y, Cun R, et al. Increased epoxyeicosatrienoic acids may be part of a protective mechanism in human ulcerative colitis, with increased CYP2J2 and reduced soluble epoxide hydrolase expression. Prostaglandins Other Lipid Mediat. 2018;136:9-14 pubmed publisher
    ..reduced sEH expression in ulcerative colitis tissues compared with matched adjacent non-inflamed tissues, whereas CYP2J2 increased in ulcerative colitis tissues (P < 0.05)...
  34. Zeldin D, Foley J, Boyle J, Moomaw C, Tomer K, Parker C, et al. Predominant expression of an arachidonate epoxygenase in islets of Langerhans cells in human and rat pancreas. Endocrinology. 1997;138:1338-46 pubmed
    Our laboratory recently described a new human cytochrome P450 arachidonic acid epoxygenase (CYP2J2) and the corresponding rat homolog (CYP2J3)...
  35. Daly A. Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases. Adv Pharmacol. 2015;74:85-111 pubmed publisher
    ..CYP2C isoforms and CYP2J2 contribute to extrahepatic metabolism of arachidonic acid to epoxyeicosanoic acids which have effects in the ..
  36. Lu J, Liu D, Zhou X, Chen A, Jiang Z, Ye X, et al. Plant natural product plumbagin presents potent inhibitory effect on human cytochrome P450 2J2 enzyme. Phytomedicine. 2018;39:137-145 pubmed publisher
    b>Cytochrome P450 2J2 (CYP2J2) is not only highly expressed in many kinds of human tumors, but also promotes tumor cell growth via regulating the metabolism of arachidonic acids...
  37. Przybyl L, Haase N, Golic M, Rugor J, Solano M, Arck P, et al. CD74-Downregulation of Placental Macrophage-Trophoblastic Interactions in Preeclampsia. Circ Res. 2016;119:55-68 pubmed publisher
    ..Trophoblasts stimulated by these factors express more CYP2J2, sFlt1, TNF?, and IL-8...
  38. Meling D, McDougle D, Das A. CYP2J2 epoxygenase membrane anchor plays an important role in facilitating electron transfer from CPR. J Inorg Biochem. 2015;142:47-53 pubmed publisher
    b>CYP2J2 epoxygenase is a membrane-bound cytochrome P450 primarily expressed in the heart and plays a significant role in cardiovascular diseases...
  39. Donnelly M, Conley Y, Crago E, Ren D, Sherwood P, Balzer J, et al. Genetic markers in the EET metabolic pathway are associated with outcomes in patients with aneurysmal subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2015;35:267-76 pubmed publisher
    ..2- and 2.5-fold more likely to develop DCI and CND (P=0.039 and P=0.041), respectively. EPHX2 55Arg, CYP2J2*7, CYP2C8*1B, and CYP2C8 g.36785A allele carriers had lower EET and DHET CSF levels. CYP2C8 g.25369T and CYP2C8 g...
  40. Murray M. CYP2J2 - regulation, function and polymorphism. Drug Metab Rev. 2016;48:351-68 pubmed publisher
    ..One of the most important human CYP epoxygenases is human CYP2J2 that is widely expressed in tissues, especially heart, vascular smooth muscle, salivary glands and placenta...
  41. Wells M, Vendrov K, Edin M, Ferslew B, Zha W, Nguyen B, et al. Characterization of the Cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis. Prostaglandins Other Lipid Mediat. 2016;125:19-29 pubmed publisher
  42. Zhou C, Huang J, Chen J, Lai J, Zhu F, Xu X, et al. CYP2J2-Derived EETs Attenuated Angiotensin II-Induced Adventitial Remodeling via Reduced Inflammatory Response. Cell Physiol Biochem. 2016;39:721-39 pubmed publisher
    ..and primary rat adventitial fibroblasts (AFs) in vitro treated with Angiotensin II to investigate the effects of CYP2J2 gene delivery and exogenous EETs administration on adventitial remodeling...
  43. Marciante K, Totah R, Heckbert S, Smith N, Lemaitre R, Lumley T, et al. Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke. Pharmacogenet Genomics. 2008;18:535-43 pubmed publisher
    The biologically active epoxyeicosatrienoic acids have protective vascular effects. CYP2J2, CYP2C8, and CYP2C9 are known to be a source of epoxyeicosatrienoic acids in cardiac tissues...
  44. Proietti G, Abelak K, Bishop Bailey D, Macchiarulo A, Nobeli I. Computational modelling of the binding of arachidonic acid to the human monooxygenase CYP2J2. J Mol Model. 2016;22:279 pubmed
    An experimentally determined structure for human CYP2J2-a member of the cytochrome P450 family with significant and diverse roles across a number of tissues-does not yet exist...
  45. Kirchheiner J, Meineke I, Fuhr U, Rodriguez Antona C, Lebedeva E, Brockmoller J. Impact of genetic polymorphisms in CYP2C8 and rosiglitazone intake on the urinary excretion of dihydroxyeicosatrienoic acids. Pharmacogenomics. 2008;9:277-88 pubmed publisher
    The cytochrome P450 enzymes CYP2C8, CYP2C9 and CYP2J2 generate 8,9-, 11,12-, and 14,15-epoxyeicosatrienic acid (EET) from arachidonic acid, and these EETs are then hydrolyzed to dihydroxyeicosatrienoic acids (DHET) before excretion into ..
  46. El Serafi I, Fares M, Abedi Valugerdi M, Afsharian P, Moshfegh A, Terelius Y, et al. Cytochrome P450 2J2, a new key enzyme in cyclophosphamide bioactivation and a potential biomarker for hematological malignancies. Pharmacogenomics J. 2015;15:405-13 pubmed publisher
    The role of cytochrome P450 2J2 (CYP2J2) in cyclophosphamide (Cy) bioactivation was investigated in patients, cells and microsomes. Gene expression analysis showed that CYP2J2 mRNA expression was significantly (P<0...
  47. Heo J, Nguyen P, Kim W, Phuc N, Liu K. Inhibitory Effect of Selaginellins from Selaginella tamariscina (Beauv.) Spring against Cytochrome P450 and Uridine 5'-Diphosphoglucuronosyltransferase Isoforms on Human Liver Microsomes. Molecules. 2017;22: pubmed publisher
    ..9 ?M, respectively. Selaginellin and selaginellin M also showed medium inhibitory potential against CYP2C9, CYP2J2, UGT1A1, and UGT1A3 (1 ?M < IC50 < 5 ?M)...
  48. Arun Kumar A, Kumar S, Umamaheswaran G, Kesavan R, Balachandar J, Adithan C. Association of CYP2C8, CYP2C9 and CYP2J2 gene polymorphisms with myocardial infarction in South Indian population. Pharmacol Rep. 2015;67:97-101 pubmed publisher
    ..CYP2C8, CYP2C9 and CYP2J2 gene involved in the metabolism of arachidonic acid, generates epoxyeicosatrienoic acids (EETs) that mediate ..
  49. Xu Y, Ding H, Peng J, Cui G, Liu L, Cianflone K, et al. Association between polymorphisms of CYP2J2 and EPHX2 genes and risk of coronary artery disease. Pharmacogenet Genomics. 2011;21:489-94 pubmed publisher
    Common polymorphisms within cytochrome P450 2J2 (CYP2J2) and epoxide hydrolase 2 (EPHX2), which are involved in the generation or hydrolysis of epoxyeicosatrienoic acids, may determine susceptibility to the development of cardiovascular ..
  50. Matsumoto S, Hirama T, Matsubara T, Nagata K, Yamazoe Y. Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole. Drug Metab Dispos. 2002;30:1240-5 pubmed
    ..Therefore, CYP2J2 cDNA has been isolated from the human cDNA library and expressed in COS-1 cells...
  51. Cong S, Ma X, Li Y, Wang J. Structural basis for the mutation-induced dysfunction of human CYP2J2: a computational study. J Chem Inf Model. 2013;53:1350-7 pubmed publisher
    ..In cardiac tissues, CYP2J2 can adopt arachidonic acid as a major substrate to produce epoxyeicosatrienoic acids (EETs), which can protect ..
  52. Alghasham A, Ali A, Ismail H, Dowaidar M, Settin A. CYP2J2 -50 G/T and ADRB2 G46A gene polymorphisms in Saudi subjects with hypertension. Genet Test Mol Biomarkers. 2012;16:1027-31 pubmed publisher
    ..This study aims to check for the association of genetic polymorphisms of the cytochrome P450 2J2 (CYP 2J2) and beta-2-adrenergic receptor (ADRB2) genes with hypertension among Saudi subjects...
  53. Smith H, Jones J, Kalhorn T, Farin F, Stapleton P, Davis C, et al. Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease. Pharmacogenet Genomics. 2008;18:943-53 pubmed publisher
    ..Cytochrome P450 2C8 (CYP2C8) and CYP2J2 are polymorphic enzymes expressed in the kidney that metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids,..
  54. Allison S, Chen Y, Petrovic N, Zhang J, Bourget K, Mackenzie P, et al. Activation of ALDH1A1 in MDA-MB-468 breast cancer cells that over-express CYP2J2 protects against paclitaxel-dependent cell death mediated by reactive oxygen species. Biochem Pharmacol. 2017;143:79-89 pubmed publisher
    b>Cytochrome P450 2J2 (CYP2J2) expression is elevated in breast and other tumours, and is known to be protective against cytotoxic agents that may be used in cancer chemotherapy...
  55. Zhang D, Lou J, Zhang X, Zhang L, Wang F, Xu D, et al. Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation. Oncotarget. 2017;8:15377-15392 pubmed publisher
    ..The levels of 4-epoxyeicosatrienoic acid (EET) isomers and their generative enzyme CYP2J2 level as well as intracellular Hcy level were higher in 42 cases of HCC than in paired non-tumor tissue...
  56. Allison S, Chen Y, Petrovic N, Zimmermann S, Moosmann B, Jansch M, et al. Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2. Int J Biochem Cell Biol. 2016;80:173-178 pubmed publisher
    Secondary metastases are the leading cause of mortality in patients with breast cancer. Cytochrome P450 (CYP) 2J2 (CYP2J2) is upregulated in many human tumors and generates epoxyeicosanoids from arachidonic acid that promote tumorigenesis ..
  57. Hwang G, Park S, Han H, Baek K, Kim J, Chang W, et al. Role of cytochrome P450 2J2 on cell proliferation and resistance to an anticancer agent in hepatocellular carcinoma HepG2 cells. Oncol Lett. 2017;14:5484-5490 pubmed publisher
    The present study examined the role of human cytochrome P450 2J2 (CYP2J2) on cell proliferation and resistance to an anticancer agent using stable hepatocellular carcinoma HepG2 cells overexpressing CYP2J2...
  58. Fava C, Montagnana M, Almgren P, Hedblad B, Engstrom G, Berglund G, et al. The common functional polymorphism -50G>T of the CYP2J2 gene is not associated with ischemic coronary and cerebrovascular events in an urban-based sample of Swedes. J Hypertens. 2010;28:294-9 pubmed publisher
    b>CYP2J2 is responsible for the production of 5,6 8,9 11,12 and 14,15-epoxyeicosatrienoic acids, vasodilator and anti-inflammatory substances. It is abundantly expressed in human heart and also present in kidney and vasculature...
  59. Plucinski L, Ranjan Gartia M, Arnold W, Ameen A, Chang T, Hsiao A, et al. Substrate binding to cytochrome P450-2J2 in Nanodiscs detected by nanoplasmonic Lycurgus cup arrays. Biosens Bioelectron. 2016;75:337-46 pubmed publisher
    ..Here we present the detection of substrate binding to cytochrome P450-2J2 (CYP2J2), the predominant P450 in the human heart, using a combination of Nanodisc technology and a nanohole plasmonic ..
  60. Jiang J, Shen G, Chen C, Fu X, Wang D. Effects of cytochrome P450 arachidonic acid epoxygenases on the proliferation of tumor cells. Ai Zheng. 2009;28:14-9 pubmed
    ..The effects of recombinant adeno-associated virus (rAAV) mediated cytochrome P450 2J2 (CYP2J2), cytochrome P450 F87V (CYPF87V) and anti-CYP2J2 on proliferation of Tca-8113, A549, Ncl-H446 and ..
  61. Borgel J, Bulut D, Hanefeld C, Neubauer H, Mugge A, Epplen J, et al. The CYP2J2 G-50T polymorphism and myocardial infarction in patients with cardiovascular risk profile. BMC Cardiovasc Disord. 2008;8:41 pubmed publisher
    ..One of the CYP2J2 products, 11, 12-epoxyeicosatrienoic acid, has several vasoprotective effects...
  62. Wu S, Zhang Y, Gardner C, Chen Q, Li Y, Wang G, et al. Evidence for association of polymorphisms in CYP2J2 and susceptibility to essential hypertension. Ann Hum Genet. 2007;71:519-25 pubmed
    Evidence from animal models and human studies suggests that CYP2J2 plays a mechanistic role in the development of hypertension...
  63. Jie Z, Hong K, Jianhong T, Biao C, Yongmei Z, Jingchuan L. Haplotype analysis of the CYP2J2 gene associated with myocardial infarction in a Chinese Han population. Cell Biochem Funct. 2010;28:435-9 pubmed publisher
    The cytochromes P450 epoxygenases CYP2J2 synthesize epoxyeicosatrienoic, which regulate endothelial function...
  64. Jones B, Markandu R, Gu C, Scarfe G. CYP-Mediated Sulfoximine Deimination of AZD6738. Drug Metab Dispos. 2017;45:1133-1138 pubmed publisher
    ..11 members of the cytochrome P450 (P450) family (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1 CYP2J2, CYP3A4, and CYP3A5) confirmed that deimination was an oxidative process that was mediated largely by CYP2C8 with ..
  65. Rani J, Mittal I, Pramanik A, Singh N, Dube N, Sharma S, et al. T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders. Sci Rep. 2017;7:6892 pubmed publisher
    ..A few genes ACE2, ADCYAP1, HDAC4, NCF1, NFE2L2, OSM, SMAD1, TGFB1, BDNF, SYVN1, TXNIP, CD36, CYP2J2, NLRP3 with details of protective role are catalogued...
  66. Yamazaki H, Okayama A, Imai N, Guengerich F, Shimizu M. Inter-individual variation of cytochrome P4502J2 expression and catalytic activities in liver microsomes from Japanese and Caucasian populations. Xenobiotica. 2006;36:1201-9 pubmed
    The aim of this study was to investigate the inter-individual variations in cytochrome P4502J2 (CYP2J2) and its typical drug oxidation activities in human liver microsomes in both Japanese and Caucasian populations...
  67. Marden N, Murray M. Characterization of a c-Jun-responsive module in the 5'-flank of the human CYP2J2 gene that regulates transactivation. Biochem J. 2005;391:631-40 pubmed
    The human cytochrome P450 2J2 (CYP2J2) generates cytoprotective epoxyeicosatrienoic acids from arachidonic acid...
  68. Lafite P, Andre F, Zeldin D, Dansette P, Mansuy D. Unusual regioselectivity and active site topology of human cytochrome P450 2J2. Biochemistry. 2007;46:10237-47 pubmed
    The oxidation of six derivatives of terfenadone by recombinant human CYP2J2 (CYP = cytochrome P450) was studied by high-performance liquid chromatography coupled to mass spectrometry (MS) using tandem MS techniques and by 1H NMR ..
  69. Lisovoĭ A, Dosenko V, Parkhomenko A, Moibenko A. [The frequency of polymorphism in promoter gene coding epoxygenase 2J2 in patents with acute coronary syndrome]. Tsitol Genet. 2010;44:53-7 pubmed
    ..05 by chi2-test). The data indicate that epoxygenase 2J2 gene polymorphism is not a risk factor of acute coronary syndrome in Ukrainian population. ..
  70. Zhu Q, Fu Z, Ma Y, Yang H, Huang D, Xie X, et al. A novel polymorphism of the CYP2J2 gene is associated with coronary artery disease in Uygur population in China. Clin Biochem. 2013;46:1047-1054 pubmed publisher
    ..The aim of the present study was to assess the association between the human CYP2J2 gene polymorphism and coronary artery disease (CAD) in a Han and Uygur population of China...
  71. Evangelista E, Kaspera R, Mokadam N, Jones J, Totah R. Activity, inhibition, and induction of cytochrome P450 2J2 in adult human primary cardiomyocytes. Drug Metab Dispos. 2013;41:2087-94 pubmed publisher
    b>Cytochrome P450 2J2 plays a significant role in the epoxidation of arachidonic acid to signaling molecules important in cardiovascular events...
  72. Geng S, Wang Y, Sun Y, Li J, Yin H, Zeng Z, et al. Gene- gene interaction between CYP2J2 and PPAR -? gene on late-onset Alzheimer's disease in the eastern Chinese Han population. Behav Brain Res. 2017;322:362-367 pubmed publisher
    To investigate the impact of PPAR -? and CYP2J2 gene single nucleotide polymorphisms (SNPs) and gene- gene interactions on late-onset Alzheimer's disease (LOAD) risk in Chinese Han population...
  73. Westphal C, Spallek B, Konkel A, Markó L, Qadri F, Degraff L, et al. CYP2J2 overexpression protects against arrhythmia susceptibility in cardiac hypertrophy. PLoS ONE. 2013;8:e73490 pubmed publisher
    ..electrical remodeling, male transgenic mice with cardiomyocyte-specific overexpression of the human epoxygenase CYP2J2 (CYP2J2-TG) and wildtype littermates (WT) were subjected to chronic pressure overload (transverse aortic ..
  74. Li R, Xu X, Chen C, Wang Y, Gruzdev A, Zeldin D, et al. CYP2J2 attenuates metabolic dysfunction in diabetic mice by reducing hepatic inflammation via the PPAR?. Am J Physiol Endocrinol Metab. 2015;308:E270-82 pubmed publisher
    ..In vivo, CYP2J2 expression and the accompanying increase in EETs attenuated insulin resistance, as determined by plasma glucose ..
  75. Huang X, Wang Y, Zhang Z, Wang Y, Chen X, Wang Y, et al. Ophiopogonin D and EETs ameliorate Ang II-induced inflammatory responses via activating PPAR? in HUVECs. Biochem Biophys Res Commun. 2017;490:123-133 pubmed publisher
    b>CYP2J2 is highly expressed in cardiovascular tissue including the heart and vascular endothelial cells. CYP2J2 and the EETs have been shown owning diverse biological effects...
  76. Wang S, Xing P, Zhang C, Deng B. Association of CYP2J2 gene polymorphisms with ischemic stroke and stroke subtypes in Chinese population. Medicine (Baltimore). 2017;96:e6266 pubmed publisher
    ..It has been demonstrated that CYP2J2 polymorphisms alter the transcriptional activity...
  77. Wu Z, Lee D, Joo J, Shin J, Kang W, Oh S, et al. CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems. Antimicrob Agents Chemother. 2013;57:5448-56 pubmed publisher
    ..Of the 10 recombinant P450s, CYP2J2 and/or CYP2C19 was the predominant enzyme catalyzing the hydroxylation of albendazole and fenbendazole...
  78. Karkhanis A, Tram N, Chan E. Effects of dronedarone, amiodarone and their active metabolites on sequential metabolism of arachidonic acid to epoxyeicosatrienoic and dihydroxyeicosatrienoic acids. Biochem Pharmacol. 2017;146:188-198 pubmed publisher
    Cardiac enzymes such as cytochrome P450 2J2 (CYP2J2) metabolize arachidonic acid (AA) to cardioprotective epoxyeicosatrienoic acids (EETs), which in turn are metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids ..
  79. Yang L, Ni L, Duan Q, Wang X, Chen C, Chen S, et al. CYP epoxygenase 2J2 prevents cardiac fibrosis by suppression of transmission of pro-inflammation from cardiomyocytes to macrophages. Prostaglandins Other Lipid Mediat. 2015;116-117:64-75 pubmed publisher
    ..Cardiac-specific human CYP2J2 transgenic mice (Tr) and wild-type (WT) C57BL/6 littermates were infused with Iso- or Ang II...