Cyp2e1

Summary

Gene Symbol: Cyp2e1
Description: cytochrome P450, family 2, subfamily E, polypeptide 1
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq]
Alias: CPE1, CYP2E, P450-J, P450C2E, 4-nitrophenol 2-hydroxylase, CYPIIE1, cytochrome P450 2E1, cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1, cytochrome P450-J, flavoprotein-linked monooxygenase, microsomal monooxygenase, xenobiotic monooxygenase
Species: human

Webpages

  1. control of drug and ethanol metabolism
    www.med.unc.edu/wrkunits/1dean/research/Thurman395.html

Publications

  1. Evidence for the catalysis of dextromethorphan O-demethylation by a CYP2D6-like enzyme in pig liver
    M Jurima-Romet
    Bureau of Biologics and Radiopharmaceuticals, Therapeutic Products Programme, Health Protection Branch, Health Canada, Tunney's Pasture
    Toxicol In Vitro 14:253-63
  2. Purification to homogeneity of the major "4S" PAH binding protein from "non responsive" DBA/2N mouse liver by affinity chromatography
    M T Masucci
    Institute of General Pathology and Oncology, I Medical School, University of Naples, Italy
    Tumori 75:202-10
  3. Additive activation of hepatic NF-kappaB by ethanol and hepatitis B protein X (HBX) or HCV core protein: involvement of TNF-alpha receptor 1-independent and -dependent mechanisms
    W H Kim
    Section on Liver Biology, Laboratory of Physiologic Studies, NIAAA, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 15:2551-3
  4. Dichloromethane as an inhibitor of cytochrome c oxidase in different tissues of rats
    A Lehnebach
    Institut für Pharmakologie und Toxikologie, Bereich Umwelttoxikologie, Martin Luther Universität, Halle Saale, Germany
    Arch Toxicol 69:180-4
  5. Polymorphism in cytochrome P450 2E1 and interaction with other genetic risk factors and susceptibility to alcoholic liver cirrhosis
    Anwar Jamal Khan
    Developmental Toxicology Division, Indian Institute of Toxicology Research Formerly ITRC, CSIR, P O Box 80, M G Marg, Lucknow 226 001, UP, India
    Mutat Res 664:55-63
  6. Increased toxicity by transforming growth factor-beta 1 in liver cells overexpressing CYP2E1
    Jian Zhuge
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Place, New York, NY 10029, USA
    Free Radic Biol Med 41:1100-12
  7. Distribution of alcohol-metabolizing enzyme genotypes in trauma patients with excessive alcohol consumption in the emergency department
    Yang Ming Tseng
    Institute of Medicine, Kaohsiung Medical University, Kaohsiung 80702, Taiwan
    Clin Biochem 40:370-6
  8. Profile of polymorphisms of drug-metabolising enzymes and the risk of therapy-related leukaemia
    Pascual Bolufer
    Laboratory of Molecular Biology Medical Biopathology, Hospital Universitario La Fe, Valencia, Spain
    Br J Haematol 136:590-6
  9. The effect of genetic polymorphisms in the vinyl chloride metabolic pathway on mutagenic risk
    Jennifer Schindler
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 60 Haven Avenue, New York, NY 10032, USA
    J Hum Genet 52:448-55
  10. CYP2E1PstI/RsaI polymorphism and interaction with tobacco, alcohol and GSTs in gastric cancer susceptibility: A meta-analysis of the literature
    Stefania Boccia
    Institute of Hygiene, Catholic University of Sacred Heart, L go F Vito, 1 00168 Rome, Italy
    Carcinogenesis 28:101-6

Scientific Experts

Detail Information

Publications66

  1. Evidence for the catalysis of dextromethorphan O-demethylation by a CYP2D6-like enzyme in pig liver
    M Jurima-Romet
    Bureau of Biologics and Radiopharmaceuticals, Therapeutic Products Programme, Health Protection Branch, Health Canada, Tunney's Pasture
    Toxicol In Vitro 14:253-63
    ..presence of proteins in pig liver which cross-reacted with anti-human CYP1A2, CYP2D6 and CYP3A4, and with anti-rat CYP2E1 antibodies...
  2. Purification to homogeneity of the major "4S" PAH binding protein from "non responsive" DBA/2N mouse liver by affinity chromatography
    M T Masucci
    Institute of General Pathology and Oncology, I Medical School, University of Naples, Italy
    Tumori 75:202-10
    ..inbred strain of mice in which administration of polycyclic aromatic hydrocarbons (PAHs) does not induce microsomal monooxygenase activity...
  3. Additive activation of hepatic NF-kappaB by ethanol and hepatitis B protein X (HBX) or HCV core protein: involvement of TNF-alpha receptor 1-independent and -dependent mechanisms
    W H Kim
    Section on Liver Biology, Laboratory of Physiologic Studies, NIAAA, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 15:2551-3
    ..Finally, chronic ethanol consumption induces hepatic CYP2E1 protein expression and potentiates HBX or HCV core protein activation of NF-kappaB in the liver...
  4. Dichloromethane as an inhibitor of cytochrome c oxidase in different tissues of rats
    A Lehnebach
    Institut für Pharmakologie und Toxikologie, Bereich Umwelttoxikologie, Martin Luther Universität, Halle Saale, Germany
    Arch Toxicol 69:180-4
    ..Based on the metabolism of dichloromethane (DCM) to carbon monoxide (CO), a process mediated by cytochrome P-4502E1 (CYP2E1), cytochrome c oxidase activity was determined in different tissues of rats after DCM exposure...
  5. Polymorphism in cytochrome P450 2E1 and interaction with other genetic risk factors and susceptibility to alcoholic liver cirrhosis
    Anwar Jamal Khan
    Developmental Toxicology Division, Indian Institute of Toxicology Research Formerly ITRC, CSIR, P O Box 80, M G Marg, Lucknow 226 001, UP, India
    Mutat Res 664:55-63
    The association of polymorphism in cytochrome P450 2E1 (CYP2E1), the major microsomal ethanol metabolizing enzyme and its interaction with genes, involved in detoxification of reactive oxygen species, such as glutathione-S-transferases ..
  6. Increased toxicity by transforming growth factor-beta 1 in liver cells overexpressing CYP2E1
    Jian Zhuge
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Place, New York, NY 10029, USA
    Free Radic Biol Med 41:1100-12
    Ethanol treatment causes an increase in expression of TGF-beta1 and CYP2E1 in the centrilobular area. Alcoholic liver disease is usually initiated in the centrilobular region of the liver...
  7. Distribution of alcohol-metabolizing enzyme genotypes in trauma patients with excessive alcohol consumption in the emergency department
    Yang Ming Tseng
    Institute of Medicine, Kaohsiung Medical University, Kaohsiung 80702, Taiwan
    Clin Biochem 40:370-6
    ..The activities of liver enzymes and genotypes of alcohol-metabolizing enzymes, including ADH2, ALDH2, and CYP2E1, were analyzed with the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis...
  8. Profile of polymorphisms of drug-metabolising enzymes and the risk of therapy-related leukaemia
    Pascual Bolufer
    Laboratory of Molecular Biology Medical Biopathology, Hospital Universitario La Fe, Valencia, Spain
    Br J Haematol 136:590-6
    ..We analysed the prevalence of genetic polymorphisms of CYP1A1*2A(T6235C), CYP2E1*5B(C-1019T), CYP3A4*1B(A-290G), del{GSTT1}, del{GSTM1}, NQO1*2(C609T), MTHFR(C677T) and TYMS 2R/3R in 78 t-AML/t-..
  9. The effect of genetic polymorphisms in the vinyl chloride metabolic pathway on mutagenic risk
    Jennifer Schindler
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 60 Haven Avenue, New York, NY 10032, USA
    J Hum Genet 52:448-55
    Vinyl chloride (VC) is a human carcinogen known to undergo metabolism by cytochrome P450 2E1 (CYP2E1) to reactive intermediates that can cause oncogene and tumor suppressor gene mutations and that are further metabolized by acetaldehyde ..
  10. CYP2E1PstI/RsaI polymorphism and interaction with tobacco, alcohol and GSTs in gastric cancer susceptibility: A meta-analysis of the literature
    Stefania Boccia
    Institute of Hygiene, Catholic University of Sacred Heart, L go F Vito, 1 00168 Rome, Italy
    Carcinogenesis 28:101-6
    Studies investigating the association between cytochrome P450 2E1 (CYP2E1) 5'-flanking region (PstI/RsaI) polymorphism and gastric cancer risk report conflicting results...
  11. CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis
    Nicolas Vuilleumier
    Central Clinical Chemistry Laboratory, Department of Clinical Pathology, Geneva University Hospital, 24 Micheli du Crest, 1211, Geneva 14, Switzerland
    Eur J Clin Pharmacol 62:423-9
    OBJECTIVE: To determine whether pharmacogenetic tests such as N-acetyltransferase 2 (NAT2) and cytochrome P450 2E1 (CYP2E1) genotyping are useful in identifying patients prone to antituberculosis drug-induced hepatotoxicity in a ..
  12. Influence of CYP1A1, CYP2E1, GSTM3 and NAT2 genetic polymorphisms in oral cancer susceptibility: results from a case-control study in Rio de Janeiro
    Christiane F S Marques
    Genetics Department, Laboratório de Genética Humana, IOC, FIOCRUZ, Pavilhão Leônidas Deane, 4365 Manguinhos, Rio de Janeiro, RJ 21045 900, Brazil
    Oral Oncol 42:632-7
    ..CYP1A1, CYP2E1, GSTM3, and NAT2 polymorphisms were determined in peripheral blood DNA of 231 oral cancer patients and 212 ..
  13. [Detoxication gene polymorphism and susceptibility to sporadic motor neuron disease in Russian population]
    V I Skvortsova
    Zh Nevrol Psikhiatr Im S S Korsakova 106:4-13
    ..The major participants of these processes are cytochromes P-450 (CYP2E1, CYP2D6), glutathione-S-transferases (GSTM1, GSTT1, GSTP1) and N-acetyltransferases (NAT2)...
  14. The absence of interaction between drug metabolizing enzyme genotypes and maternal lifestyle factors on glycophorin A somatic mutation frequency levels in newborns
    Tomoko Nukui
    Center for Clinical Pharmacology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Pharmacogenet Genomics 16:129-38
    ..blood samples from 406 mother/newborn pairs were genotyped for a panel of phase I/II metabolic enzymes (CYP1A1, CYP2E1, GSTM1, GSTT1 and NAT2) responsible for the metabolism of tobacco and lifestyle-related mutagens and carcinogens...
  15. Molecular cloning and expression of novel alternatively spliced cytochrome P450 2E1 mRNAs in humans
    Mario Bauer
    Department of Human Exposure Research and Epidemiology, UFZ Centre for Environmental Research Leipzig Halle, Permoser Street 15, 04318, Leipzig, Germany
    Mol Cell Biochem 280:201-7
    Human cytochrome P450 2E1 (CYP2E1) is a phase I metabolizing enzyme. It is involved in the biotransformation of xenobiotics and endogenous substrates...
  16. Distribution of cytochrome P450 2C, 2E1, 3A4, and 3A5 in human colon mucosa
    Ina Bergheim
    Hohenheim University 140, Dep, Physiology of Nutrition, Stuttgart, Germany
    BMC Clin Pharmacol 5:4
    ..Therefore, expression and protein levels of four representative CYPs (CYP2C(8), CYP2E1, CYP3A4, and CYP3A5) were determined in human colon mucosa biopsies obtained from ascending, descending and ..
  17. Gene-environmental interactions between alcohol-drinking behavior and ALDH2 and CYP2E1 polymorphisms and their impact on micronuclei frequency in human lymphocytes
    Hitoshi Ishikawa
    Department of Public Health and Occupational Medicine, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Mutat Res 594:1-9
    Ethanol is converted to acetaldehyde by alcohol dehydrogenase (ADH), cytochrome p4502E1 (CYP2E1) and catalase...
  18. Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease
    Ehtesham Arif
    Functional Genomics Unit, Institute of Genomics and Integrative Biology, Delhi, India
    Clin Chim Acta 382:37-42
    ..METHODS: We conducted a case-control study to investigate total 9 polymorphisms of CYP2E1, CYP2D6 and NAT2 genes by PCR-RFLP...
  19. CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit and vegetables and risk of head and neck cancer
    Stefania Boccia
    Genetic Epidemiology and Molecular Biology Unit, Institute of Hygiene, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy
    J Cancer Res Clin Oncol 134:93-100
    ..METHODS: A total of 210 cases and 245 hospital controls, age and gender matched, were genotyped for CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms...
  20. Expression and activity of the cytochrome P450 2E1 in patients with nonalcoholic steatosis and steatohepatitis
    Haithem Chtioui
    Institute of Clinical Pharmacology, University of Bern, Bern, Switzerland
    Liver Int 27:764-71
    ..The pathogenesis of NASH implicates the overexpression of cytochrome P450 2E1 (CYP2E1)...
  21. Bax inhibitor 1 regulates ER-stress-induced ROS accumulation through the regulation of cytochrome P450 2E1
    Hyung Ryong Kim
    Department of Dental Pharmacology, School of Dentistry, Wonkwang University, Iksan, Chonbuk, 570 749, Republic of Korea
    J Cell Sci 122:1126-33
    ..Electron uncoupling between NADPH-dependent cytochrome P450 reductase (NPR) and cytochrome P450 2E1 (P450 2E1) is a major source of ROS on the ER membrane...
  22. Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population
    Hui Hung Wang
    Institute of Biomedical Sciences, Academia Sinica, No 128, Sec 2, Academia Road, Nankang, Taipei 11529, Taiwan
    Pharmacogenomics 10:359-74
    ..Among these variants, an 11-nucleotide insertion in the 3-flanking site of intron 6 in CYP2E1 (c.968-77_-76insGATGGGTGGAT) had the highest allele frequency of 0.565...
  23. Biomarkers of human exposure to acrylamide and relation to polymorphisms in metabolizing genes
    Nur Duale
    Norwegian Institute of Public Health, Division of Environmental Medicine, Nydalen, NO 0403 Oslo, Norway
    Toxicol Sci 108:90-9
    ..AA is readily absorbed in the body and converted to glycidamide (GA) by epoxidation by the CYP2E1 (cytochrome P450 2E) enzyme...
  24. Lysophosphatidylserine-induced functional switch of human cytochrome P450 1A2 and 2E1 from monooxygenase to phospholipase D
    Eun Yi Cho
    School of Biological Sciences and Technology and Hormone Research Center, Chonnam National University Gwangju 500 757, Republic of Korea
    Biochem Biophys Res Commun 376:584-9
    Interaction of human cytochrome P450 1A2 (CYP1A2) and 2E1 (CYP2E1) with phospholipid, lysophosphatidylserine (LysoPS) in the context of a PC matrix specifically stimulated the PLD activity of both enzymes in a LysoPS concentration-..
  25. Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans
    Sang Yong Eom
    Department of Preventive Medicine, College of Medicine, Chungbuk National University, 12 Gaeshin Dong, Heungdok gu, Cheongju, Chungbuk, 361 763, Republic of Korea
    Cancer Causes Control 20:137-45
    OBJECTIVES: We investigated the association of genetic polymorphisms of NQO1, ALDH2, CYP2E1, and the combined genotype of these genes on lung cancer risk, and also evaluated the association after stratification by cumulative smoking ..
  26. Study of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, nonalcoholic steatohepatitis obese women
    Nelson M Varela
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Biol Res 41:81-92
    b>CYP2E1 enzyme is related to nonalcoholic steatohepatitis (NASH) due to its ability for reactive oxygen species production, which can be influenced by polymorphisms in the gene...
  27. Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and Glutathione-S-transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients
    Katsumi Fukino
    Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    J Toxicol Sci 33:187-95
    ..Genotype distributions of N-acetyltransferase 2 (NAT2), CYP2E1*5B, CYP2E1*6, Glutathione-S-transferase (GST) M1 and GST T1 were similar to those already reported in Japanese ..
  28. Development and properties of HepG2 cells that constitutively express CYP2E1
    Defeng Wu
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Biol 447:137-50
    b>CYP2E1, a member of the cytochrome P450 family, is induced by ethanol. CYP2E1 activates many hepatotoxins to their reactive toxic intermediate form, and generates reactive oxygen species (ROS) during its catalytic cycle...
  29. Novel hierarchical classification and visualization method for multiobjective optimization of drug properties: application to structure-activity relationship analysis of cytochrome P450 metabolism
    Fumiyoshi Yamashita
    Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshidashimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    J Chem Inf Model 48:364-9
    ..g., CYP2C9 substrates are anionic compounds, while CYP2D6 substrates are cationic; and CYP2E1 substrates are smaller compounds, while CYP3A4 substrates are larger compounds.
  30. Polymorphisms of GSTP1 and GSTT1, but not of CYP2A6, CYP2E1 or GSTM1, modify the risk for esophageal cancer in a western population
    A Rossini
    Departamento de Bioquímica, IBRAG, Universidade do Estado do Rio de Janeiro, RJ 20551 013, Brasil
    Carcinogenesis 28:2537-42
    ..the risk of ESCC associated with tobacco and alcohol consumption and with polymorphisms of CYP2A6 (CYP2A6*2), CYP2E1 (CYP2E1*5B, CYP2E1*6), GSTP1 (Ile105Val), GSTM1 and GSTT1 null genotypes in 126 cases and 252 age- and gender-..
  31. Genetic polymorphisms and possible gene-gene interactions in metabolic and DNA repair genes: effects on DNA damage
    Alessio Naccarati
    Inst Exper Medicine, Acad Sci of the Czech Republic, Videnska 1083, 14200 Prague 4, Czech Republic
    Mutat Res 593:22-31
    ..the association between genetic polymorphisms in several genes coding for xenobiotic metabolizing enzymes (CYP1A1, CYP2E1, EPHX1, GSTP1, GSTM1 and GSTT1) and in DNA repair genes (XPD, XPG, XPC and XRCC1) and the levels of single-strand ..
  32. Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer
    Hong Mei Nan
    Department of Preventive Medicine, College of Medicine, Chungbuk National University, 12 Kaeshin dong, Hungdok gu, Cheongju Si, Chungbuk 361 763, Republic of Korea
    World J Gastroenterol 11:3834-41
    ..Hypermethylation of the hMLH1 gene promoter, polymorphisms of the GSTM1, GSTT1, CYP1A1, CYP2E1, ALDH2 and L-myc genes, microsatellite instability and mutations of p53 and Ki-ras genes were investigated...
  33. Cytochrome P4502E1 primes macrophages to increase TNF-alpha production in response to lipopolysaccharide
    Qi Cao
    Alcohol Research Center, Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Am J Physiol Gastrointest Liver Physiol 289:G95-107
    ..Because cytochrome P4502E1 (CYP2E1) is upregulated in Kupffer cells after ethanol, we hypothesized that this effect primes Kupffer cells, sensitizing ..
  34. Genetic polymorphisms in the 5'-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene
    S Hayashi
    Department of Biochemistry, Saitama Cancer Center Research Institute
    J Biochem 110:559-65
    ..This may lead to inter-individual differences of microsomal drug oxidation activity...
  35. Cytochrome P450 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells
    Natalia Nieto
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 277:9853-64
    ..a model was developed using co-cultures of HepG2 cells, which do (E47 cells) or do not (C34 cells) express cytochrome P450 2E1 (CYP2E1) with stellate cells...
  36. The FANCG Fanconi anemia protein interacts with CYP2E1: possible role in protection against oxidative DNA damage
    Makoto Futaki
    Hematology Branch, NHLBI, NIH, Building 10, Room 7C103, Bethesda, MD 20892, USA
    Carcinogenesis 23:67-72
    ..analysis for proteins that associate with FANCG, we identified a novel interaction between FANCG and cytochrome P450 2E1 (CYP2E1)...
  37. Association between polymorphisms of ethanol-metabolizing enzymes and susceptibility to alcoholic cirrhosis in a Korean male population
    H C Lee
    Department of Internal Medicine, Seoul National University, College of Medicine, Korea
    J Korean Med Sci 16:745-50
    Alcohol is oxidized to acetaldehyde by alcohol dehydrogenase (ADH) and cytochrome P-4502E1 (CYP2E1), and then to acetate by aldehyde dehydrogenase (ALDH)...
  38. Effects of genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 on the urinary levels of 1-hydroxypyrene and 2-naphthol in aircraft maintenance workers
    C Y Lee
    Department of Preventive Medicine, School of Medicine, KyungBuk National University, 101 Dongin dong 2 ga, Jung Gu, 700 422, Taegu, South Korea
    Toxicol Lett 123:115-24
    ..was undertaken to investigate the effects of genetic polymorphisms of the cytochrome P450 1A1 (CYP1A1) and 2E1 (CYP2E1), and glutathione S-transferases mu (GSTM1) and theta (GSTT1) on urinary 1-hydroxypyrene and 2-naphthol levels, ..
  39. Role of genetic factors in development and progression of non-Hodgkin's lymphomas
    P Soucek
    Biotransformation Group, Center of Occupational Diseases, National Institute of Public Health, Prague, Czech Republic
    Cent Eur J Public Health 9:74-8
    ..Preliminary statistical analyses showed no association of CYP1A1-m1/m2, CYP2E1-c1/c2, GSTM1null, and GSTT1null genotypes with incidence and status of NHL...
  40. Cytochrome P450 2E1 polymorphism and nasopharyngeal carcinoma development in Thailand: a correlative study
    N Kongruttanachok
    Genetics Unit, Department of Anatomy, National Cancer Institute, Bangkok, Thailand
    BMC Cancer 1:4
    ..The cytochrome P450 2E1 enzyme (CYP2E1) is responsible for the metabolic activation of nitrosamines, and has been shown to be a ..
  41. Allele and genotype frequencies of polymorphic cytochromes P4502D6, 2C19 and 2E1 in aborigines from western Australia
    E U Griese
    Dr Marcgarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
    Pharmacogenetics 11:69-76
    The polymorphisms of the important xenobiotic metabolizing enzymes CYP2D6, CYP2C19 and CYP2E1 have been studied extensively in a large number of populations and show significant heterogeneity in the frequency of different alleles/..
  42. Chinese alcoholic patients with esophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosis
    Y C Chao
    Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Am J Gastroenterol 95:2958-64
    ..The Chinese alcoholic patients with the ADH2*1 and ALDH2*2 allele are more susceptible to esophageal Ca...
  43. Cytochrome P4502E (CYP2E) in brain: constitutive expression, induction by ethanol and localization by fluorescence in situ hybridization
    S C Upadhya
    Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, 560 029, India
    Arch Biochem Biophys 373:23-34
    ..Northern blot analysis of rat and human brain poly(A)(+) RNA hybridized with cDNA to rat CYP2E1 revealed the constitutive presence of a corresponding transcript in rat and human brain...
  44. Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic properties
    E M Gillam
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146
    Arch Biochem Biophys 312:59-66
    ..N-Terminal amino acid sequence analysis yielded the expected first 21 residues. The expression system should facilitate the availability of human P450 2E1 and antibodies for studies of the enzyme...
  45. Human liver cytochrome P-450 related to a rat acetone-inducible, nitrosamine-metabolizing cytochrome P-450: identification and isolation
    R C Robinson
    Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, MD
    Pharmacology 39:137-44
    ..This report thus demonstrates the utility of MAbs to rat cytochromes P-450 for detection, identification and structural characterization of human P-450s...
  46. Cytochrome P450 2E1 genetic polymorphism and gastric cancer in Changle, Fujian Province
    L Cai
    Department of Epidemiology, Fujian Medical University, Fuzhou 350004, Fujian Province, China
    World J Gastroenterol 7:792-5
    ..b>Cytochrome P450 2E1 (CYP2E1) is considered to play an important role in the metabolic activation of procarcinogens such as N-..
  47. Childhood acute lymphoblastic leukemia associated with parental alcohol consumption and polymorphisms of carcinogen-metabolizing genes
    Claire Infante Rivard
    Joint Department of Epidemiology and Biostatistics, Faculty of Medicine, McGill University, Montréal, Québec, Canada
    Epidemiology 13:277-81
    ..186 cases to estimate interaction odds ratios between prenatal exposure and child DNA variants in the GSTM1 and CYP2E1 genes. RESULTS: The adjusted odds ratio for any maternal consumption during pregnancy was 0...
  48. Polymorphism in alcohol-metabolizing enzymes, glutathione S-transferases and apolipoprotein E and susceptibility to alcohol-induced cirrhosis and chronic pancreatitis
    Andreas Frenzer
    Department of Gastroenterology, The Queen Elizabeth Hospital, Adelaide, SA, Australia
    J Gastroenterol Hepatol 17:177-82
    ..frequencies of alcohol dehydrogenase-2 (ADH2), ADH3, aldehyde dehydrogenase-2 (ALDH2), cytochrome P450-2E1 (CYP2E1), glutathione S-transferase-M1 (GSTM1), GSTT1, and apolipoprotein E in patients with alcoholic cirrhosis and ..
  49. [Association of metabolic and DNA repair enzyme gene polymorphisms and DNA damage in coke-oven workers]
    Juan Cheng
    National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China
    Zhonghua Yu Fang Yi Xue Za Zhi 39:164-7
    ..The genotypes of CYP1A1, CYP2E1, GSTP1, NQO1, mEH and XRCC1 were determined by PCR-based methods...
  50. Association of cytochrome P450 2E1 genetic polymorphisms with squamous cell carcinoma of the oesophagus
    Dongping Li
    MRC UCT Oesophageal Cancer Research Group, Institute of Infectious Disease and Molecular Medicine, Division of Medical Biochemistry, Faculty of Health Sciences, University of Cape Town, South Africa
    Clin Chem Lab Med 43:370-5
    ..Genetic polymorphism in the cytochrome P450 2E1 (CYP2E1) gene, coding for one of the main enzymes involved in the bioactivation of tobacco- and alcohol-..
  51. Phase I/II enzyme gene polymorphisms and esophageal cancer risk: a meta-analysis of the literature
    Chun xia Yang
    Department of Epidemiology, Huaxi Public Health School, Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 11:2531-8
    ..articles, we obtained 16 studies related to the CYP1A1 Ile-Val substitution in exon 7, CYP1A1 MspI polymorphisms, CYP2E1 RsaI polymorphisms, GSTM1 null type, GSTT1 null type and GSTP1 Ile104Val. All were of case-control design...
  52. Association of metabolic gene polymorphisms with alcohol consumption in controls
    S Raimondi
    Molecular and Genetic Epidemiology Unit, Ospedale Policlinico IRCCS, Milan, Italy
    Biomarkers 9:180-9
    The objectives were to study the association between metabolic genes involved in alcohol metabolism (CYP2E1 RsaI, CYP2E1 DraI, ADH1C, NQO1) and alcohol consumption in a large sample of healthy controls...
  53. Association of cytochrome P450 2E1 polymorphisms and head and neck squamous cell cancer
    Thomas Neuhaus
    Medizinische Universitäts Poliklinik Bonn, Universität Bonn, Wilhelmstr 35 37, D 53111 Bonn, Germany
    Toxicol Lett 151:273-82
    ..Analyzing a correlation between certain neoplasia and alteration of the CYP2E1 gene, most studies focus on the polymorphisms -1053C>T and 7632T>A, but recently another polymorphism, named -71G>..
  54. Evidence of association of the CYP2E1 genetic polymorphism with micronuclei frequency in human peripheral blood
    Hitoshi Ishikawa
    Department of Public Health and Preventive Medicine, Mie University School of Medicine, Edobashi 2 174, Tsu 514 8507, Japan
    Mutat Res 546:45-53
    ..The subjects with the CYP2E1(*)3 variant allele had a statistically lower mean MN frequency than subjects with the CYP2E1(*)1/(*)1 wild type...
  55. CYP2E1*1D regulatory polymorphism: association with alcohol and nicotine dependence
    Lisa A Howard
    Department of Pharmacology, University of Toronto, Ontario, Canada
    Pharmacogenetics 13:321-8
    OBJECTIVE: CYP2E1 bioactivates environmental protoxins and metabolizes alcohol. CYP2E1 is induced by alcohol and cigarette smoking and may contribute to metabolic tolerance in alcoholics...
  56. Genetic susceptibility for emphysematous changes of the lung in Japanese
    Antariksa Budhi
    Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Int J Mol Med 11:321-9
    ..in the activation or detoxification of tobacco smoke, epoxide hydrolase (EPHX1), cytochrome P450s (CYP1A1 and CYP2E1), glutathione S-transferases (GSTM1/P1/T1), and hemoxygenase-1 (HMOX1), were determined by PCR-based assays in a ..
  57. Polymorphisms for chemical metabolizing genes and risk for cervical neoplasia
    Carlos H Sierra Torres
    Department of Preventive Medicine and Community Health, 700 Harborside Drive, University of Texas Medical Branch, Galveston, TX 77555, USA
    Environ Mol Mutagen 41:69-76
    ..that environmental exposure to cigarette smoke and inheritance of polymorphic chemical metabolizing genes (CYP2E1, GSTM1, and mEH) significantly increase the risk for neoplasia...
  58. Influence of metabolic genotypes on biomarkers of exposure to 1,3-butadiene in humans
    Silvia Fustinoni
    Dipartimento di Medicina del Lavoro, Istituti Clinici di Perfezionamento, Milano, Italy 20122
    Cancer Epidemiol Biomarkers Prev 11:1082-90
    ..were found in subjects with GSTM1 null and GSTT1 null genotypes; borderline influences were also noticed for CYP2E1(G(-35)T)...
  59. Case-control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymes
    Shama C Buch
    Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Head Neck 30:1139-47
    ..oral squamous cell carcinoma cases and 416 controls for single nucleotide polymorphisms (SNPs) in 8 genes (CYP1A1, CYP2E1, MPO, mEH, GSTM1, GSTT1, GSTP1, and NAT2). Except for NAT2, genotype frequencies were similar in the 2 groups...
  60. Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males
    Yan Mei Guo
    Department of Clinical Medicine, Gansu College of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China
    World J Gastroenterol 14:1444-9
    AIM: To evaluate the association between genetic polymorphisms in CYP2E1, ALDH2 and ADH1B and the risk of esophageal squamous cell carcinoma (ESCC) in a high risk area of Gansu Province, in Chinese males...
  61. Interaction between a single nucleotide polymorphism in the alcohol dehydrogenase 3 gene, alcohol consumption and oral cancer risk
    Athanasios I Zavras
    Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, MA, USA
    Int J Cancer 97:526-30
    ..We also evaluated a SNP in CYP2E1, another gene involved in ethanol metabolism, reported to be associated with OC risk in a European population...
  62. Effect of the CYP2E1 genotype on vinyl chloride monomer-induced liver fibrosis among polyvinyl chloride workers
    Hui I Hsieh
    Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Zhongzheng District, Taipei City, Taiwan
    Toxicology 239:34-44
    ..b>Cytochrome P450 2E1 (CYP2E1), aldehyde dehydrogenase 2 (ALDH2) and glutathione S-transferase theta 1 (GSTT1) enzymes are ..