CYP24A1

Summary

Gene Symbol: CYP24A1
Description: cytochrome P450 family 24 subfamily A member 1
Alias: CP24, CYP24, HCAI, HCINF1, P450-CC24, 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial, 1,25-@dihydroxyvitamin D3 24-hydroxylase, 24-OHase, cytochrome P450 24A1, cytochrome P450, family 24, subfamily A, polypeptide 1, cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase), cytochrome P450-CC24, exo-mitochondrial protein, vitamin D 24-hydroxylase, vitamin D(3) 24-hydroxylase
Species: human
Products:     CYP24A1

Top Publications

  1. Tashiro K, Ishii C, Ryoji M. Role of distal upstream sequence in vitamin D-induced expression of human CYP24 gene. Biochem Biophys Res Commun. 2007;358:259-65 pubmed
    The level of CYP24 mRNA in cultured human fibroblasts increases up to 20,000-fold in response to 1,25-dihydroxyvitamin D(3)...
  2. Matusiak D, Benya R. CYP27A1 and CYP24 expression as a function of malignant transformation in the colon. J Histochem Cytochem. 2007;55:1257-64 pubmed
    ..Similarly, increasing amounts of the deactivating enzyme CYP24 are present in the nuclei of normal colonic epithelia, ACFs, and adenomatous polyps...
  3. Chen K, DeLuca H. Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements. Biochim Biophys Acta. 1995;1263:1-9 pubmed
    ..Further characterization of these VDREs in various constructs with either a native or TK promoter suggests that both VDREs are required for the optimal induction of 24-hydroxylase expression by 1,25-(OH)2D3. ..
  4. Holick C, Stanford J, Kwon E, Ostrander E, Nejentsev S, Peters U. Comprehensive association analysis of the vitamin D pathway genes, VDR, CYP27B1, and CYP24A1, in prostate cancer. Cancer Epidemiol Biomarkers Prev. 2007;16:1990-9 pubmed
    ..encoding for vitamin D activating enzyme 1-alpha-hydroxylase (CYP27B1) and deactivating enzyme 24-hyroxylase (CYP24A1) and prostate cancer risk among middle-aged men using a population-based case-control study design...
  5. Anderson L, Cotterchio M, Knight J, Borgida A, Gallinger S, Cleary S. Genetic variants in vitamin d pathway genes and risk of pancreas cancer; results from a population-based case-control study in ontario, Canada. PLoS ONE. 2013;8:e66768 pubmed publisher
    ..SNPs in the CYP24A1, CYP2R1, calcium sensing receptor (CASR), vitamin D binding protein (GC), retinoid X receptor-alpha (RXRA) and ..
  6. Sakaki T, Yasuda K, Kittaka A, Yamamoto K, Chen T. CYP24A1 as a potential target for cancer therapy. Anticancer Agents Med Chem. 2014;14:97-108 pubmed
    ..Thus, it is plausible to assume that rapid clearance of 1?,25(OH)2D3 by highly expressed CYP24A1 could interrupt the normal physiology of cells and might be one cause of cancer initiation and progression...
  7. Horváth H, Lakatos P, Kósa J, Bacsi K, Borka K, Bises G, et al. The candidate oncogene CYP24A1: A potential biomarker for colorectal tumorigenesis. J Histochem Cytochem. 2010;58:277-85 pubmed publisher
    ..Because 25-hydroxyvitamin D(3) 24-hydroxylase (CYP24A1) is considered to be the main enzyme determining the biological half-life of 1,25-D(3), we have examined ..
  8. Pascussi J, Robert A, Nguyen M, Walrant Debray O, Garabedian M, Martin P, et al. Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia. J Clin Invest. 2005;115:177-86 pubmed
    ..Here we show that these drugs lead to the upregulation of 25-hydroxyvitamin D(3)-24-hydroxylase (CYP24) gene expression through the activation of the nuclear receptor pregnane X receptor (PXR; NR1I2)...
  9. Dong L, Ulrich C, Hsu L, Duggan D, Benitez D, White E, et al. Genetic variation in calcium-sensing receptor and risk for colon cancer. Cancer Epidemiol Biomarkers Prev. 2008;17:2755-65 pubmed publisher
    ..08). We did not observe any meaningful gene-environment (calcium and vitamin D) or gene-gene (CYP24A1, CYP27B1, and VDR) interactions with CASR genotypes and colon cancer risk...

More Information

Publications83

  1. Urbschat A, Paulus P, von Quernheim Q, Bruck P, Badenhoop K, Zeuzem S, et al. Vitamin D hydroxylases CYP2R1, CYP27B1 and CYP24A1 in renal cell carcinoma. Eur J Clin Invest. 2013;43:1282-90 pubmed publisher
    ..Concerning the synthesis of vitamin D, the hydroxylases CYP2R1, CYP27B1 and CYP24A1 play a critical role, and the latter molecule determines the biological half-life of 1,25(OH)2 D3 , which is ..
  2. Horvath E, Lakatos P, Balla B, Kosa J, Tóbiás B, Jozilan H, et al. Marked increase of CYP24A1 mRNA level in hepatocellular carcinoma cell lines following vitamin D administration. Anticancer Res. 2012;32:4791-6 pubmed
    ..We aimed to examine the mRNA and protein expression of 1,25(OH)(2)D(3)-inactivating CYP24A1 and mRNA expression of the activating CYP27B1 enzymes, as well as that of vitamin D receptor (VDR), in ..
  3. Avila E, Díaz L, Barrera D, Halhali A, Mendez I, Gonzalez L, et al. Regulation of Vitamin D hydroxylases gene expression by 1,25-dihydroxyvitamin D3 and cyclic AMP in cultured human syncytiotrophoblasts. J Steroid Biochem Mol Biol. 2007;103:90-6 pubmed
    ..through the activity of 25-hydroxyvitamin D(3)-1alpha-hydroxylase (CYP27B1) and 1,25(OH)(2)D(3)-24-hydroxylase (CYP24A1), the two key enzymes for Vitamin D metabolism...
  4. Ahn J, Albanes D, Berndt S, Peters U, Chatterjee N, Freedman N, et al. Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. Carcinogenesis. 2009;30:769-76 pubmed publisher
    ..investigated the association of 48 SNPS in four vitamin D metabolizing genes [CYP27A1, GC, CYP27B1 and CYP24A1] with serum 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)(2)D] levels and the association ..
  5. Dusso A, Brown A, Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol. 2005;289:F8-28 pubmed
    ..This local production of 1,25(OH)(2)D(3) is dependent on circulating precursor levels, providing a potential explanation for the association of vitamin D deficiency with various cancers and autoimmune diseases. ..
  6. Dong L, Ulrich C, Hsu L, Duggan D, Benitez D, White E, et al. Vitamin D related genes, CYP24A1 and CYP27B1, and colon cancer risk. Cancer Epidemiol Biomarkers Prev. 2009;18:2540-8 pubmed publisher
    ..vitamin D activating enzyme 1-alpha hydroxylase (CYP27B1) and vitamin D deactivating enzyme 24-alpha hydroxylase (CYP24A1)...
  7. Dorjgochoo T, Delahanty R, Lu W, Long J, Cai Q, Zheng Y, et al. Common genetic variants in the vitamin D pathway including genome-wide associated variants are not associated with breast cancer risk among Chinese women. Cancer Epidemiol Biomarkers Prev. 2011;20:2313-6 pubmed publisher
    ..only rs12570116 in the ACADSB gene, rs4760658 in the VDR gene and rs6091822, rs8124792, and rs6097809 in the CYP24A1 gene, and rs10902845 in C10orf88 had a nominal association with breast cancer risk (P < 0.05 for all)...
  8. Muindi J, Yu W, Ma Y, Engler K, Kong R, Trump D, et al. CYP24A1 inhibition enhances the antitumor activity of calcitriol. Endocrinology. 2010;151:4301-12 pubmed publisher
    ..Therefore, we investigated whether the inhibition of 24-hydroxylase (CYP24A1), the major calcitriol inactivating enzyme, by ketoconazole (KTZ) or RC2204 modulates calcitriol serum ..
  9. Bu F, Armas L, Lappe J, Zhou Y, Gao G, Wang H, et al. Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects. Hum Genet. 2010;128:549-56 pubmed publisher
    ..The CYP2R1 gene and the GC gene remain significant in the pooled cohort. The results suggest that the CYP2R1 and GC genes may contribute to the variation of serum 25(OH)D levels in healthy populations. ..
  10. Lopes N, Sousa B, Martins D, Gomes M, Vieira D, Veronese L, et al. Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions. BMC Cancer. 2010;10:483 pubmed publisher
    ..D receptor (VDR) and the synthesis and degradation of this hormone are regulated by the enzymes CYP27B1 and CYP24A1, respectively...
  11. Novakovic B, Sibson M, Ng H, Manuelpillai U, Rakyan V, Down T, et al. Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface. J Biol Chem. 2009;284:14838-48 pubmed publisher
    ..tightly controlled via feedback regulation of renal 1alpha-hydroxylase (CYP27B1; positive) and 24-hydroxylase (CYP24A1; catabolic) enzymes...
  12. Clinckspoor I, Hauben E, Verlinden L, Van Den Bruel A, Vanwalleghem L, Vander Poorten V, et al. Altered expression of key players in vitamin D metabolism and signaling in malignant and benign thyroid tumors. J Histochem Cytochem. 2012;60:502-11 pubmed publisher
    ..Vitamin D receptor (VDR) and CYP27B1 and CYP24A1 (respectively activating and catabolizing vitamin D) expression was studied (RT-PCR, immunohistochemistry) in ..
  13. Wang T, Zhang F, Richards J, Kestenbaum B, van Meurs J, Berry D, et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet. 2010;376:180-8 pubmed publisher
    ..3x10(-20) for rs10741657, near CYP2R1). Variants at an additional locus (20q13, CYP24A1) were genome-wide significant in the pooled sample (p=6.0x10(-10) for rs6013897)...
  14. Luo W, Karpf A, Deeb K, Muindi J, Morrison C, Johnson C, et al. Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 in human prostate cancer. Cancer Res. 2010;70:5953-62 pubmed publisher
    Calcitriol, a regulator of calcium homeostasis with antitumor properties, is degraded by the product of the CYP24A1 gene, which is downregulated in human prostate cancer by unknown mechanisms...
  15. Cooper J, Smyth D, Walker N, Stevens H, Burren O, Wallace C, et al. Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes. 2011;60:1624-31 pubmed publisher
    ..We replicated the associations of four vitamin D metabolism genes (GC, DHCR7, CYP2R1, and CYP24A1) with 25(OH)D in control subjects...
  16. Kósa J, Horvath P, Wolfling J, Kovacs D, Balla B, Matyus P, et al. CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells. World J Gastroenterol. 2013;19:2621-8 pubmed publisher
    ..25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered ..
  17. Moreau A, Maurel P, Vilarem M, Pascussi J. Constitutive androstane receptor-vitamin D receptor crosstalk: consequence on CYP24 gene expression. Biochem Biophys Res Commun. 2007;360:76-82 pubmed
    ..reported that the pregnane X receptor (PXR) interferes with vitamin D receptor (VDR) target genes, notably CYP24, by targeting the same responsive elements...
  18. Vigano P, Lattuada D, Mangioni S, Ermellino L, Vignali M, Caporizzo E, et al. Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. J Mol Endocrinol. 2006;36:415-24 pubmed
    ..interleukin (IL)-1beta (50 and 500 pg/ml) while addition of the active form of the hormone could modulate both CYP24 and osteopontin gene expression...
  19. Parise R, Egorin M, Kanterewicz B, Taimi M, Petkovich M, Lew A, et al. CYP24, the enzyme that catabolizes the antiproliferative agent vitamin D, is increased in lung cancer. Int J Cancer. 2006;119:1819-28 pubmed
    ..In evaluating factors that may affect activity in NSCLC, the authors found that CYP24 (25-hydroxyvitamin D3-24-hydroxylase), the enzyme that catabolizes 1,25D3, is frequently expressed in NSCLC cell ..
  20. Wjst M, Altmuller J, Faus Kessler T, Braig C, Bahnweg M, André E. Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway. Respir Res. 2006;7:60 pubmed
    ..05 for asthma or total IgE and calcidiol or calcitriol was seen in IL10, GC, IL12B, CYP2R1, IL4R, and CYP24A1. Consistent strong genotypic association could not be observed...
  21. Tieu E, Tang E, Tuckey R. Kinetic analysis of human CYP24A1 metabolism of vitamin D via the C24-oxidation pathway. FEBS J. 2014;281:3280-96 pubmed publisher
    b>CYP24A1 is the multicatalytic cytochrome P450 responsible for the catabolism of vitamin D via the C23- and C24-oxidation pathways...
  22. Väisänen S, Dunlop T, Sinkkonen L, Frank C, Carlberg C. Spatio-temporal activation of chromatin on the human CYP24 gene promoter in the presence of 1alpha,25-Dihydroxyvitamin D3. J Mol Biol. 2005;350:65-77 pubmed
    The vitamin D3 24-hydroxylase gene (CYP24) is one of the most strongly induced genes known. Despite this, its induction by the hormone 1alpha,25-dihydroxyvitamin D3 (1alpha,25OH2D3) has been characterized only partially...
  23. Mimori K, Tanaka Y, Yoshinaga K, Masuda T, Yamashita K, Okamoto M, et al. Clinical significance of the overexpression of the candidate oncogene CYP24 in esophageal cancer. Ann Oncol. 2004;15:236-41 pubmed
    By using array comparative genomic hybridization (CGH), the increased copy number of CYP24 (which encodes vitamin D 24-hydroxylase) at 20q13...
  24. Theodoropoulos C, Demers C, Delvin E, Menard D, Gascon Barre M. Calcitriol regulates the expression of the genes encoding the three key vitamin D3 hydroxylases and the drug-metabolizing enzyme CYP3A4 in the human fetal intestine. Clin Endocrinol (Oxf). 2003;58:489-99 pubmed
    ..on the expression levels of the three key D3-hydroxylase gene transcripts (25-hydroxylase, CYP27A; 24-hydroxylase, CYP24; 1alpha-hydroxylase, CYP27B1) as well as that of the 1,25(OH)2D3-responsive endobiotic/xenobiotic metabolizing ..
  25. Bailey R, Cooper J, Zeitels L, Smyth D, Yang J, Walker N, et al. Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. Diabetes. 2007;56:2616-21 pubmed
    ..by the enzyme 1 alpha-hydroxylase encoded by the CYP27B1 gene and is inactivated by 24-hydroxylase encoded by the CYP24A1 gene. Our aim was to study the association between the CYP27B1 and CYP24A1 gene polymorphisms and type 1 diabetes...
  26. Deeb K, Luo W, Karpf A, Omilian A, Bshara W, Tian L, et al. Differential vitamin D 24-hydroxylase/CYP24A1 gene promoter methylation in endothelium from benign and malignant human prostate. Epigenetics. 2011;6:994-1000 pubmed publisher
    Epigenetic alterations occur in tumor-associated vessels in the tumor microenvironment. Methylation of the CYP24A1 gene promoter differs in endothelial cells isolated from tumors and non-tumor microenvironments in mice...
  27. Chen G, Kim S, King A, Zhao L, Simpson R, Christensen P, et al. CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinoma. Clin Cancer Res. 2011;17:817-26 pubmed publisher
    ..b>CYP24A1 is overexpressed in many cancers and encodes the enzyme that catabolizes 1,25-D(3)...
  28. Shen H, Bielak L, Ferguson J, Streeten E, Yerges Armstrong L, Liu J, et al. Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification. Arterioscler Thromb Vasc Biol. 2010;30:2648-54 pubmed publisher
    ..We genotyped single-nucleotide polymorphisms (SNPs) in GC, CYP27B1, CYP24A1, and VDR and tested their association with CAC quantity, as measured by electron beam computed tomography...
  29. Holt S, Kwon E, Koopmeiners J, Lin D, Feng Z, Ostrander E, et al. Vitamin D pathway gene variants and prostate cancer prognosis. Prostate. 2010;70:1448-60 pubmed publisher
    ..VDR), vitamin D activating enzyme 1-alpha-hydroxylase (CYP27B1), and deactivating enzyme 24-hydroxylase (CYP24A1) in a cohort of 1,294 Caucasian cases with an average of 8 years of follow-up...
  30. Matilainen J, Malinen M, Turunen M, Carlberg C, Väisänen S. The number of vitamin D receptor binding sites defines the different vitamin D responsiveness of the CYP24 gene in malignant and normal mammary cells. J Biol Chem. 2010;285:24174-83 pubmed publisher
    ..According to previous studies, the gene encoding 25-dihydroxyvitamin D(3) 24-hydroxylase, CYP24, which is the strongest known 1alpha,25(OH)(2)D(3)-responsive gene, has multiple VDREs that locate within the ..
  31. Ren S, Nguyen L, Wu S, Encinas C, Adams J, Hewison M. Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis. J Biol Chem. 2005;280:20604-11 pubmed
    ..that this is due to abnormal catabolism of 1,25-(OH)(2)D by the feedback control enzyme, vitamin D-24-hydroxylase (CYP24)...
  32. Abboud M, Rybchyn M, Rizk R, Fraser D, Mason R. Sunlight exposure is just one of the factors which influence vitamin D status. Photochem Photobiol Sci. 2017;16:302-313 pubmed publisher
    ..D, GC, coding for the vitamin D binding protein which transports 25(OH)D and other metabolites in blood and CYP24A1, which 24-hydroxylates both 25(OH)D and the hormone, 1,25-dihydroxyvitamin D...
  33. Slominski A, Brozyna A, Zmijewski M, Jozwicki W, Jetten A, Mason R, et al. Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management. Lab Invest. 2017;97:706-724 pubmed publisher
    ..of CYP11A1 to produce mono-di- and trihydroxy-D3 products that can be further modified by CYP27B1, CYP27A1, and CYP24A1. The active forms of D3, in addition to regulating calcium metabolism, exert pleiotropic activities, which ..
  34. Park H, Wood M, Malysheva O, Jones S, Mehta S, Brannon P, et al. Placental vitamin D metabolism and its associations with circulating vitamin D metabolites in pregnant women. Am J Clin Nutr. 2017;106:1439-1448 pubmed publisher
    ..with 25(OH)D3; 25-hydroxylase (CYP2R1) with 3-epi-25(OH)D3; 24-hydroxylase (CYP24A1) with 25(OH)D3, 3-epi-25(OH)D3, and 1,25-dihydroxyvitamin D3 [1,25(OH)2<..
  35. El Kholy M, Elsedfy H, Fernandez Cancio M, Hamza R, Amr N, Ahmed A, et al. Nutritional rickets: vitamin D, calcium, and the genetic make-up. Pediatr Res. 2017;81:356-363 pubmed publisher
    ..Fifty-four single-nucleotide polymorphisms (SNPs) of five vitD system genes (VDR, CP2R1, CYP27B1, CYP24A1, and GC) were genotyped and their association with clinical and biochemcial data was analyzed...
  36. Yu S, Li X, Wang Y, Mao Z, Wang C, Ba Y, et al. Transmission disequilibrium of rs4809957 in type 2 diabetes mellitus families and its association with vitamin D deficiency: A family-based case-control study. J Diabetes Complications. 2018;32:406-410 pubmed publisher
    Association between T2DM and vitamin D was found in many epidemiologic reports. And 24-hydroxylase encoded by CYP24A1 is the very enzyme that degrades the active vitamin D metabolite...
  37. Nguyen T, Lieberherr M, Fritsch J, Guillozo H, Alvarez M, Fitouri Z, et al. The rapid effects of 1,25-dihydroxyvitamin D3 require the vitamin D receptor and influence 24-hydroxylase activity: studies in human skin fibroblasts bearing vitamin D receptor mutations. J Biol Chem. 2004;279:7591-7 pubmed
    ..and magnitude) and 24-hydroxylase responses to low (1 pm-100 pm) 1,25-(OH)(2)D(3) concentrations (activity, CYP24, and ferredoxin mRNAs) similar to those of controls...
  38. Wilke R, Simpson R, Mukesh B, Bhupathi S, Dart R, Ghebranious N, et al. Genetic variation in CYP27B1 is associated with congestive heart failure in patients with hypertension. Pharmacogenomics. 2009;10:1789-97 pubmed publisher
    ..Functional polymorphisms were selected from five candidate genes: CYP27B1, CYP24A1, VDR, REN and ACE...
  39. Cui M, Zhao Y, Hance K, Shao A, Wood R, Fleet J. Effects of MAPK signaling on 1,25-dihydroxyvitamin D-mediated CYP24 gene expression in the enterocyte-like cell line, Caco-2. J Cell Physiol. 2009;219:132-42 pubmed publisher
    ..1,25(OH)(2)D(3)-regulated expression of the 25-hydroxyvitamin D, 24-hydroxylase (CYP24) gene (both natural gene and promoter construct) was strongly modulated by altering ERK activity (i.e...
  40. Xu P, Roy L, Croce R. Functional organization of photosystem II antenna complexes: CP29 under the spotlight. Biochim Biophys Acta Bioenerg. 2017;1858:815-822 pubmed publisher
    ..In this work, we purified CP29 and its larger assembly (CP29-LHCII-CP24) from the membrane in very mild conditions using a His-tag, and we have studied their pigment binding and ..
  41. Roff A, Wilson R. A novel SNP in a vitamin D response element of the CYP24A1 promoter reduces protein binding, transactivation, and gene expression. J Steroid Biochem Mol Biol. 2008;112:47-54 pubmed publisher
    ..We sought to identify functionally significant polymorphic variants in CYP24A1, a gene that is highly inducible by 1alpha,25(OH)(2)D(3) and that encodes the primary catabolic enzyme in the ..
  42. Ramnath N, Daignault Newton S, Dy G, Muindi J, Adjei A, Elingrod V, et al. A phase I/II pharmacokinetic and pharmacogenomic study of calcitriol in combination with cisplatin and docetaxel in advanced non-small-cell lung cancer. Cancer Chemother Pharmacol. 2013;71:1173-82 pubmed publisher
    ..A two-stage design was employed for phase II portion. We correlated CYP24A1 tagSNPs with clinical outcome and 1,25-D3 pharmacokinetics (PK). 34 patients were enrolled...
  43. Horvath E, Balla B, Kosa J, Lakatos P, Lazary A, Nemeth D, et al. [Vitamin D metabolism and signaling in human hepatocellular carcinoma and surrounding non-tumorous liver]. Orv Hetil. 2016;157:1910-1918 pubmed
    ..We examined mRNA and protein expression differences in 1,25-Dihydroxy vitamin D3-inactivating CYP24A1, mRNA of activating CYP27B1 enzymes, and that of VDR between human hepatocellular carcinoma and surrounding non-..
  44. Wierzbicka J, Binek A, Ahrends T, Nowacka J, SzydÅ‚owska A, Turczyk Å, et al. Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture. Int J Oncol. 2015;47:1084-96 pubmed publisher
    ..Decreased levels of VDR and increased CYP24A1 expression in clinical samples underline the importance of deregulation of vitamin D pathways in the development ..
  45. Shah A, Hsiao E, O Donnell B, Salmeen K, Nussbaum R, Krebs M, et al. Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations. J Clin Endocrinol Metab. 2015;100:2832-6 pubmed publisher
    ..revealed low 24,25-dihydroxyvitamin D3 and high 25-hydroxyvitamin D3 levels, suggesting loss of function of CYP24A1 (25-hydroxyvitamin-D3-24-hydroxylase)...
  46. Chen M, Heinrich G, Ohyama Y, Okuda K, Omdahl J, Chen T, et al. Expression of 25-hydroxyvitamin D3-24-hydroxylase mRNA in cultured human keratinocytes. Proc Soc Exp Biol Med. 1994;207:57-61 pubmed
    ..These results demonstrate that 1 alpha,25(OH)2D3 up-regulates the expression of 24-OHase mRNA, and this may be an important first step in the initiation of catabolism of 1 alpha,25(OH)2D3 in human keratinocytes. ..
  47. Zhu M, Qiu S, Zhang X, Wang Y, Souraka T, Wen X, et al. The associations between CYP24A1 polymorphisms and cancer susceptibility: A meta-analysis and trial sequential analysis. Pathol Res Pract. 2018;214:53-63 pubmed publisher
    Published data have shown that vitamin D may have a protective effect on cancer development. CYP24A1, the main enzyme responsible for the degradation of active vitamin D, plays an important role in many cancer related cellular processes...
  48. Chen K, Prahl J, DeLuca H. Isolation and expression of human 1,25-dihydroxyvitamin D3 24-hydroxylase cDNA. Proc Natl Acad Sci U S A. 1993;90:4543-7 pubmed
    ..Transient levels of 24-hydroxylase activity were measured in transfected mammalian COS-1 cells and in recombinant baculovirus-infected Spodoptera frugiperda (Sf21) insect cells. ..
  49. Razali N, Abdul Aziz A, Lim C, Mat Junit S. Investigation into the effects of antioxidant-rich extract of Tamarindus indica leaf on antioxidant enzyme activities, oxidative stress and gene expression profiles in HepG2 cells. Peerj. 2015;3:e1292 pubmed publisher
    ..The expression of KNG1, SERPINC1, SERPIND1, SERPINE1, FGG, FGA, MVK, DHCR24, CYP24A1, ALDH6A1, EPHX1 and LEAP2 were amongst the highly regulated...
  50. O Brien K, Li S, Cao C, Kent T, Young B, Queenan R, et al. Placental CYP27B1 and CYP24A1 expression in human placental tissue and their association with maternal and neonatal calcitropic hormones. J Clin Endocrinol Metab. 2014;99:1348-56 pubmed publisher
    ..contribute to circulating maternal calcitriol concentrations across gestation, but determinants of CYP27B1 and CYP24A1 expression in term human placental tissue are not well established...
  51. Hobaus J, Fetahu I, Khorchide M, Manhardt T, Kállay E. Epigenetic regulation of the 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1) in colon cancer cells. J Steroid Biochem Mol Biol. 2013;136:296-9 pubmed publisher
    ..Calcitriol and its precursor calcidiol (25(OH)D3) are degraded by the 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1)...
  52. McCullough M, Stevens V, Diver W, Feigelson H, Rodriguez C, Bostick R, et al. Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study. Breast Cancer Res. 2007;9:R9 pubmed
    ..We also examined one SNP in the 24-hydroxylase gene (CYP24A1) and two in the vitamin D-binding protein (group-specific component [GC]) gene...
  53. Pronicka E, Ciara E, Halat P, Janiec A, Wójcik M, Rowińska E, et al. Biallelic mutations in CYP24A1 or SLC34A1 as a cause of infantile idiopathic hypercalcemia (IIH) with vitamin D hypersensitivity: molecular study of 11 historical IIH cases. J Appl Genet. 2017;58:349-353 pubmed publisher
    ..It was recently discovered that the condition is linked to two genes, CYP24A1 and SLC34A1...
  54. Balla B, Kósa J, Tóbiás B, Halászlaki C, Takacs I, Horváth H, et al. Marked increase in CYP24A1 gene expression in human papillary thyroid cancer. Thyroid. 2011;21:459-60 pubmed publisher
  55. Guo C, Rosoha E, Lowry M, Borregaard N, Gombart A. Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway. J Nutr Biochem. 2013;24:754-9 pubmed publisher
    ..VDR target genes - human cathelicidin antimicrobial peptide (CAMP) and 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1) - in human monocytic cell line U937, colon cancer cell line HT-29 and keratinocyte cell line HaCaT...
  56. Kaukinen A, Siiskonen H, Pelkonen J, Harvima I. Immunoreactivity to CYP24A1, but not vitamin D receptor, is increased in mast cells of keratinocyte skin cancers. Eur J Dermatol. 2017;27:590-598 pubmed publisher
    ..However, VDR activation leads to the expression of CYP24A1, a hydroxylase that can inactivate vitamin D3 metabolites...
  57. Allegra S, Cusato J, De Francia S, Arduino A, Longo F, Pirro E, et al. Role of CYP24A1, VDR and GC gene polymorphisms on deferasirox pharmacokinetics and clinical outcomes. Pharmacogenomics J. 2017;: pubmed publisher
    ..Allelic discrimination for VDR, CYP24A1, CYP27B1 and GC gene SNPs was performed by real-time PCR...
  58. Ishizawa M, Akagi D, Yamamoto J, Makishima M. 1?,25-Dihydroxyvitamin D3 enhances TRPV6 transcription through p38 MAPK activation and GADD45 expression. J Steroid Biochem Mol Biol. 2017;172:55-61 pubmed publisher
    ..1,25(OH)2D3 induces TRPV6 mRNA expression at lower concentrations than for induction of CYP24A1, a VDR target gene involved in vitamin D inactivation, in intestinal SW480 cells, suggesting an additional ..
  59. Ikezoe T, Bandobashi K, Yang Y, Takeuchi S, Sekiguchi N, Sakai S, et al. HIV-1 protease inhibitor ritonavir potentiates the effect of 1,25-dihydroxyvitamin D3 to induce growth arrest and differentiation of human myeloid leukemia cells via down-regulation of CYP24. Leuk Res. 2006;30:1005-11 pubmed
    ..This study explored the effects of RTV on CYP24 which converts 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] to its inactive form 1,24,25,(OH)(3)...
  60. Prosser D, Kaufmann M, O Leary B, Byford V, Jones G. Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone. Proc Natl Acad Sci U S A. 2007;104:12673-8 pubmed
    Studies of 25-hydroxyvitamin D(3)-24-hydroxylase (CYP24A1) have demonstrated that it is a bifunctional enzyme capable of the 24-hydroxylation of 1alpha,25-(OH)(2)D(3), leading to the excretory form, calcitroic acid, and 23-hydroxylation, ..
  61. Martin L, Blangero J, Rogers J, Mahaney M, Hixson J, Carey K, et al. A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20. Physiol Genomics. 2001;5:75-80 pubmed
    ..several potential candidate genes including melanocortin 3 receptor (MC3R), cytochrome P-450 subfamily XXIV (CYP24), and breast carcinoma amplified sequence (BCAS1)...
  62. Ramos Lopez E, Bruck P, Jansen T, Pfeilschifter J, Radeke H, Badenhoop K. CYP2R1-, CYP27B1- and CYP24-mRNA expression in German type 1 diabetes patients. J Steroid Biochem Mol Biol. 2007;103:807-10 pubmed
    ..CYP2R1), the 25-hydroxyvitamin-D(3)-1-alpha-hydroxylase (CYP27B1) and the 25(OH)D(3)-24-hydroxylase (CYP24) among others...
  63. Liu E, Martins J, Raimann A, Chae B, Brooks D, Jorgetti V, et al. 1,25-Dihydroxyvitamin D Alone Improves Skeletal Growth, Microarchitecture, and Strength in a Murine Model of XLH, Despite Enhanced FGF23 Expression. J Bone Miner Res. 2016;31:929-39 pubmed publisher
    ..2016 American Society for Bone and Mineral Research. ..
  64. Masuda S, Strugnell S, Knutson J, St Arnaud R, Jones G. Evidence for the activation of 1alpha-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1alpha,24-dihydroxyvitamin D2 and 1alpha,25-dihydroxyvitamin D2. Biochim Biophys Acta. 2006;1761:221-34 pubmed
    ..We used keratinocytes and recombinant human enzyme to test if the 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) is capable of target cell activation and inactivation of a model prodrug, 1alpha-hydroxyvitamin D2 (1alpha(OH)D2)..
  65. Shintani T, Rosli S, Takatsu F, Choon Y, Hayashido Y, Toratani S, et al. Eldecalcitol (ED-71), an analog of 1α,25-dihydroxyvitamin D3 as a potential anti-cancer agent for oral squamous cell carcinomas. J Steroid Biochem Mol Biol. 2016;164:79-84 pubmed publisher
    ..As Cyp24A1 was reportedly induced in cancer cells, we measured the expression of CYP24A1 in OSCC cell lines (NA and UE), ..
  66. Ruggiero B, Padwa B, Christoph K, Zhou S, Glowacki J. Vitamin D metabolism and regulation in pediatric MSCs. J Steroid Biochem Mol Biol. 2016;164:287-291 pubmed publisher
    ..was constitutive expression of vitamin D receptor (VDR), megalin, d-hydroxylases (CYP27B1, CYP27A1, CYP2R1, and CYP24A1), and estrogen receptor (ER). There was 2.6-fold greater expression of CYP27B1 and 3...
  67. Hibler E, Klimentidis Y, Jurutka P, Kohler L, Lance P, Roe D, et al. CYP24A1 and CYP27B1 Polymorphisms, Concentrations of Vitamin D Metabolites, and Odds of Colorectal Adenoma Recurrence. Nutr Cancer. 2015;67:1131-41 pubmed publisher
    ..However, less is known regarding colorectal neoplasia risk and variation in CYP27B1 or CYP24A1, genes encoding the enzymes responsible for the synthesis and catabolism of 1α,25-hydroxyvitamin D [1,25(OH)2D]..
  68. Zaghlool A, Halvardson J, Zhao J, Etemadikhah M, Kalushkova A, Konska K, et al. A Role for the Chromatin-Remodeling Factor BAZ1A in Neurodevelopment. Hum Mutat. 2016;37:964-75 pubmed publisher
    ..Our results show that the patient displays decreased binding of ACF1 to the promoter of the VDR-regulated gene CYP24A1. Using RNA sequencing, we find that the mutation affects the expression of genes involved in several pathways ..
  69. Taban I, Zhu J, DeLuca H, Simons C. Synthesis, molecular modelling and CYP24A1 inhibitory activity of novel of (E)-N-(2-(1H-imidazol-1-yl)-2-(phenylethyl)-3/4-styrylbenzamides. Bioorg Med Chem. 2017;25:4076-4087 pubmed publisher
    b>CYP24A1 (25-hydroxyvitamin D-24-hydroxylase) is a useful enzyme target for a range of medical conditions including cancer, cardiovascular and autoimmune disease, which show elevated CYP24A1 levels and corresponding reduction of ..
  70. Anderson P. Vitamin D Activity and Metabolism in Bone. Curr Osteoporos Rep. 2017;15:443-449 pubmed publisher
    ..via 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1), and 25-hydroxyvitamin D 24-hydroxylase (CYP24A1) enzymes, respectively...
  71. Battaglia S, Karasik E, Gillard B, Williams J, Winchester T, Moser M, et al. LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer. Clin Epigenetics. 2017;9:82 pubmed publisher
    ..The role of LSD1 in VDR-mediated gene transcription was evaluated for Cdkn1a, E2f1, Cyp24a1, and S100g via qRT-PCR-TaqMan and via chromatin immunoprecipitation assay...
  72. Gong C, Long Z, Yu Y, Zhu L, Tian J, Li S, et al. Dietary factors and polymorphisms in vitamin D metabolism genes: the risk and prognosis of colorectal cancer in northeast China. Sci Rep. 2017;7:8827 pubmed publisher
    b>CYP24A1 and CYP27B1 are critical genes determining 1?,25(OH)2D3 concentration and impacting on carcinogenesis...
  73. Hahn C, Baker E, Laslo P, May B, Omdahl J, Sutherland G. Localization of the human vitamin D 24-hydroxylase gene (CYP24) to chromosome 20q13.2-->q13.3. Cytogenet Cell Genet. 1993;62:192-3 pubmed
  74. Bonnet L, Karkeni E, Couturier C, Astier J, Dalifard J, Defoort C, et al. Gene Expression Pattern in Response to Cholecalciferol Supplementation Highlights Cubilin as a Major Protein of 25(OH)D Uptake in Adipocytes and Male Mice White Adipose Tissue. Endocrinology. 2018;159:957-966 pubmed publisher
    ..day) for 4 days showed decreased messenger RNA (mRNA) levels of proteins involved in cholecalciferol metabolism (Cyp24a1, Cyp27a1) and decreased cubilin mRNA levels in WAT...