Cyp1A1

Summary

Gene Symbol: Cyp1A1
Description: cytochrome P450, family 1, subfamily A, polypeptide 1
Alias: AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX, CYPIA1, aryl hydrocarbon hydroxylase, cytochrome P1-450, dioxin-inducible, cytochrome P450 1A1, cytochrome P450 form 6, cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1, cytochrome P450-C, cytochrome P450-P1, flavoprotein-linked monooxygenase, xenobiotic monooxygenase
Species: human

Top Publications

  1. ncbi A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer
    Christoph Sachse
    Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Carcinogenesis 23:1839-49. 2002
  2. doi Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis
    Theodoros N Sergentanis
    School of Medicine, National University of Athens, Athens, Greece
    Breast Cancer Res Treat 122:459-69. 2010
  3. doi Polymorphisms of CYP1A1 and GSTM1 and laryngeal cancer risk: evidence-based meta-analyses
    Wen lei Zhuo
    Institute of Cancer, Xinqiao Hospital, Third Military Medical University, 400038 Chongqing, China
    J Cancer Res Clin Oncol 135:1081-90. 2009
  4. ncbi Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers
    K Tsukasaki
    Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, 90024, USA
    Cancer Res 61:3770-4. 2001
  5. pmc Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta-analysis
    Jayaram Vijayakrishnan
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Haematologica 95:1405-14. 2010
  6. pmc Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002033. 2011
  7. pmc Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women
    Michele L Cote
    Population Studies and Prevention Program, Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI 48201, USA
    Carcinogenesis 30:626-35. 2009
  8. ncbi Genetic polymorphism of cytochrome P4501A1 and susceptibility to oral squamous cell carcinoma and oral precancer lesions associated with smoking/betel use
    Shou Yen Kao
    Department of Dentistry, Oral and Maxillofacial Surgery, Taipei Veterans General Hospital, Taiwan, ROC
    J Oral Pathol Med 31:505-11. 2002
  9. doi CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations
    Kyoung Mu Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 17:1120-6. 2008
  10. pmc Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on GxE interactions and pathogenic pathways
    Hui Ju Tsai
    Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Hum Genet 123:359-69. 2008

Detail Information

Publications247 found, 100 shown here

  1. ncbi A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer
    Christoph Sachse
    Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Carcinogenesis 23:1839-49. 2002
    ..and 593 controls (433 matched case-control pairs) were genotyped for common polymorphisms in the cytochrome P450 (CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C9, CYP2C19 and CYP2D6), glutathione S-transferase (GSTM1, GSTP1 and GSTT1), ..
  2. doi Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis
    Theodoros N Sergentanis
    School of Medicine, National University of Athens, Athens, Greece
    Breast Cancer Res Treat 122:459-69. 2010
    Cytochrome P450s are enzymes which catalyze Phase-I metabolism reactions; cytochrome P450 1A1 (CYP1A1) is a member of the CYP1 family and participates in the metabolism of a vast number of xenobiotics, as well as endogenous substrates...
  3. doi Polymorphisms of CYP1A1 and GSTM1 and laryngeal cancer risk: evidence-based meta-analyses
    Wen lei Zhuo
    Institute of Cancer, Xinqiao Hospital, Third Military Medical University, 400038 Chongqing, China
    J Cancer Res Clin Oncol 135:1081-90. 2009
    Previous evidence implicates CYP1A1 and GSTM1 polymorphisms as risk factors for various cancers...
  4. ncbi Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers
    K Tsukasaki
    Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, 90024, USA
    Cancer Res 61:3770-4. 2001
    ..to ATL and several polymorphisms: the three "decreased-detoxifying" polymorphisms in GSTM1, GSTT1, and CYP1A1, the "proapoptotic" polymorphism in BCL2, and the five "high-production" polymorphisms in tumor necrosis factor ..
  5. pmc Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta-analysis
    Jayaram Vijayakrishnan
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Haematologica 95:1405-14. 2010
    ..73, 95%ci:0.59-0.91), shmt1 c1420t (or=0.79, 95%ci: 0.65-0.98), rfc1 g80a (or=1.37, 95%ci: 1.11-1.69), cyp1a1*2a (or=1.36, 95%ci:1.11-1.66), cyp2e1*5b (or=1.99, 95%ci:1.32-3.00) nqo1 c609t (or=1.24, 95%ci:1.02-1...
  6. pmc Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002033. 2011
    ..4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2...
  7. pmc Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women
    Michele L Cote
    Population Studies and Prevention Program, Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI 48201, USA
    Carcinogenesis 30:626-35. 2009
    ..Eleven SNPs in 10 different genes were examined in relation to risk: CYP1A1 Msp1, CYP1A1 Ile462Val, CYP1B1 Leu432Val, CYP17, CYP19A1, XRCC1 Gln399Arg, COMT Val158Met, NQO1 Pro187Ser, GSTM1, ..
  8. ncbi Genetic polymorphism of cytochrome P4501A1 and susceptibility to oral squamous cell carcinoma and oral precancer lesions associated with smoking/betel use
    Shou Yen Kao
    Department of Dentistry, Oral and Maxillofacial Surgery, Taipei Veterans General Hospital, Taiwan, ROC
    J Oral Pathol Med 31:505-11. 2002
    The importance of the CYP1A1 polymorphisms at exon 7 (Ile/Val) and 3'-untranslated region (3'-UTR) has been controversial in oral squamous cell carcinoma (OSCC) or head and neck SCC (HNSCC) denoting the value of exploring the correlation ..
  9. doi CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations
    Kyoung Mu Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 17:1120-6. 2008
    To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] and deletion of GSTM1 and GSTT1 in lung cancer development in Asian populations, a pooled analysis was conducted on 13 existing studies included in Genetic ..
  10. pmc Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on GxE interactions and pathogenic pathways
    Hui Ju Tsai
    Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Hum Genet 123:359-69. 2008
    ..Previously, we reported that maternal smoking and metabolic gene polymorphisms of CYP1A1 MspI and GSTT1 synergistically increase the risk of low birth weight...
  11. ncbi CYP1A1 polymorphisms and risk of prostate cancer: a meta-analysis
    Abjal Pasha Shaik
    Research Wing, Indo AmericanCancer Hospital and ResearchCentre, Hyderabad, India
    Urol J 6:78-86. 2009
    Two common polymorphisms in cytochrome P450; family 1, subfamily A, polypeptide 1 (CYP1A1); have been implicated as a risk factor of prostate cancer, but individual studies have been inconclusive or controversial...
  12. doi A case-control study of CYP1A1, GSTT1 and GSTM1 gene polymorphisms, pregnancy smoking and fetal growth restriction
    Ali Delpisheh
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, UK
    Eur J Obstet Gynecol Reprod Biol 143:38-42. 2009
    To determine the role of maternal CYP1A1, GSTT1, and GSTM1 metabolic gene polymorphisms in modulating the association between pregnancy smoking exposure and fetal growth restriction.
  13. doi Meta-analysis of cytochrome P4501A1 MspI gene polymorphism and childhood acute leukemia
    Yao Dong Zhang
    Department of Endocrinology, Zhengzhou Children s Hospital, Zhengzhou 450053, Henan, China
    Biomed Environ Sci 24:683-7. 2011
    To investigate the relationship between cytochrome P4501A1 (CYP1A1) Msp I gene polymorphism and childhood acute leukemia (AL).
  14. ncbi Genetic polymorphism of the CYP1A1, CYP2E1, GSTM1 and GSTT1 genes and lung cancer susceptibility in a north indian population
    R C Sobti
    Department of Biotechnology, Punjab University, Chandigarh, India
    Mol Cell Biochem 266:1-9. 2004
    b>CYP1A1, CYP2E1, GSTM1 and GSTT1 polymorphisms were evaluated in north Indian lung cancer patients and controls. The estimated relative risk for lung cancer associated with the CYP1A1*2C allele was 2.68...
  15. ncbi Relationship between genetic polymorphisms of drug-metabolizing enzymes (CYP1A1, CYP2E1, GSTM1, and NAT2), drinking habits, histological subtypes, and p53 gene point mutations in Japanese patients with gastric cancer
    Shioto Suzuki
    Department of Molecular and Cellular Pathology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    J Gastroenterol 39:220-30. 2004
    ..Therefore, we studied the relationship between the genetic polymorphisms of drug-metabolizing enzymes, drinking habits, histological subtypes, and p53 gene point mutations in Japanese patients with gastric cancer...
  16. doi Association between CYP1A1 polymorphism and colorectal cancer risk: a meta-analysis
    Yuan Zheng
    Department of Center for Disease Control and Prevention of Shaanxi Province, 3Jiandong Road, 710054, Shaanxi, Xi an, People s Republic of China
    Mol Biol Rep 39:3533-40. 2012
    ..Published data on the association between CYP1A1 (MspI and Ile ( 462 ) ..
  17. doi Association of cytochrome P450, glutathione S-transferase and N-acetyl transferase 2 gene polymorphisms with incidence of acute myeloid leukemia
    Sunipa Majumdar
    Department of Biophysics, Molecular Biology and Genetics, University of Calcutta, India
    Eur J Cancer Prev 17:125-32. 2008
    ....
  18. ncbi CYP1A1 polymorphisms and risk of lung cancer in non-smoking Chinese women: influence of environmental tobacco smoke exposure and GSTM1/T1 genetic variation
    Daniel P K Ng
    Department of Community, Occupational and Family Medicine, National University of Singapore, 16 Medical Drive MD3, Singapore 117597
    Cancer Causes Control 16:399-405. 2005
    We examined whether polymorphisms of CYP1A1, which plays a role in the metabolic activation of polycyclic aromatic hydrocarbons (PAHs), confer an increased risk of lung cancer in lifetime non-smoking Chinese women.
  19. doi Lung cancer risk in north Indian population: role of genetic polymorphisms and smoking
    Munish Kumar
    Petroleum Toxicology Division, Indian Institute of Toxicology Research, M G Marg, P O Box No 80, Lucknow, 226001, India
    Mol Cell Biochem 322:73-9. 2009
    ..The polymorphic genes explored were CYP1A1, GSTM1, GSTP1 and GSTT1 using techniques of Polymerase chain reaction (PCR), Restriction Fragment Length ..
  20. ncbi CYP1A1 polymorphisms modify overall survival in acute myeloid leukemia patients
    Luis Arthur Flores Pelloso
    Leuk Lymphoma 48:1211-5. 2007
  21. doi Association studies of CYP1A1 and GSTM1 polymorphisms with esophageal cancer risk: evidence-based meta-analyses
    Wen lei Zhuo
    Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    Arch Med Res 40:169-79. 2009
    Previous studies have implicated cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) polymorphisms as risk factors for various cancers...
  22. ncbi CYP1A1, cigarette smoking, and colon and rectal cancer
    Martha L Slattery
    Health Research Center, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Am J Epidemiol 160:842-52. 2004
    ..The authors evaluated the association of two polymorphisms in the CYP1A1 gene--the noncoding Msp I polymorphism in the 3'-untranslated region and the Ile462Val polymorphism in exon 7--..
  23. ncbi Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review
    L F Masson
    Epidemiology Group, Department of Public Health, University of Aberdeen, Aberdeen, Scotland
    Am J Epidemiol 161:901-15. 2005
    ..It is expressed predominantly in extrahepatic tissues, including the breast. Four CYP1A1 gene polymorphisms (3801T --> C, Ile462Val, 3205T --> C, and Thr461Asp) have been studied in relation to ..
  24. ncbi Glutathione S-transferase genotypes and allergic responses to diisocyanate exposure
    P Piirilä
    Departments of Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland
    Pharmacogenetics 11:437-45. 2001
    ..0, 95% CI 2.19-55.3). The results suggest, for the first time, that the polymorphic GSTs, especially the mu class GSTs, play an important role in inception of ill effects related to occupational exposure to diisocyanates...
  25. ncbi CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people
    L Quinones
    Faculty of Medicine, Laboratory of Environmental Toxicology and School of Public Health, University of Chile, Santiago, Chile
    Cancer Lett 174:35-44. 2001
    b>CYP1A1, CYP2E1 and GSTM1 polymorphisms were evaluated in Chilean healthy controls and lung cancer patients...
  26. ncbi Polymorphisms of CYP1A1 and glutathione S-transferase and susceptibility to adult acute myeloid leukemia
    Francesco D'Alo
    Istituto di Ematologia, Universita Cattolica S Cuore, Rome, Italy
    Haematologica 89:664-70. 2004
    ..We studied the polymorphisms of cytochrome P450 CYP1A1 and glutathione S-transferase (GST), enzymes involved in the metabolism of carcinogens and anti-cancer drugs, as ..
  27. ncbi Polymorphism in CYP1A1 and CYP2E1 genes and susceptibility to leukoplakia in Indian tobacco users
    Nilabja Sikdar
    Anthropology and Human Genetics Unit, Biological Sciences Division, Indian Statistical Institute, 203 B T Road, Kolkata 700108, India
    Cancer Lett 195:33-42. 2003
    ..In this study, we investigated polymorphisms at two sites in the CYP1A1 and three sites in the CYP2E1 genes in 99 leukoplakia patients and 227 controls from one Indian population...
  28. ncbi CYP1B1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women
    Kyong Ah Yoon
    Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, South Korea
    Lung Cancer 60:40-6. 2008
    ..Here, we investigated the association of CYP1A1 Ile462Val, CYP1B1 Leu432Val, GSTP1 Ile105Val, MPO G-463A polymorphisms and lung cancer risk in never-smoking ..
  29. doi Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in nonsmall cell lung cancer
    C M Wright
    Dept of Thoracic Medicine, Room 2, Level 1 Clinical Sciences Building, The Prince Charles Hospital, Chermside, QLD, Australia
    Eur Respir J 35:152-9. 2010
    ..Phase I enzymes, including cytochrome P(450), family 1, subfamily A, polypeptide 1 (CYP1A1), are involved in the activation of carcinogens, such as polycyclic aromatic hydrocarbons, to reactive ..
  30. pmc Combinations of cytochrome P-450 genotypes and risk of early-onset lung cancer in Caucasians and African Americans: a population-based study
    M L Cote
    Population Studies and Prevention Program, Karmanos Cancer Institute at Wayne State University School of Medicine, Detroit, MI, United States
    Lung Cancer 55:255-62. 2007
    Polymorphisms in CYP1A1 and CYP1B1 genes in humans are associated with reduction of enzymatic activity towards several substrates, including those found in tobacco smoke...
  31. ncbi CYP1A1 variants and smoking-related lung cancer in San Francisco Bay area Latinos and African Americans
    Margaret R Wrensch
    Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, USA
    Int J Cancer 113:141-7. 2005
    We examined CYP1A1 T6235C (M1) and A4889G (M2) polymorphisms in San Francisco Bay Area African Americans and Latinos who were newly diagnosed with primary lung cancer from September 1998 to November 2002 and in age-gender-ethnicity ..
  32. ncbi Cytochrome P450 1A1 polymorphism and childhood leukemia: an analysis of matched pairs case-control genotype data
    Steve Selvin
    School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA
    Cancer Epidemiol Biomarkers Prev 13:1371-4. 2004
    The association between the genotypic frequencies of the cytochrome P450 1A1 polymorphism and the risk of childhood leukemia is explored with the data from a matched case-control study...
  33. doi Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated meta-analysis including 1,515 cases and 2,233 controls
    Xianlu Zhuo
    Department of Stomatology, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    Tumour Biol 33:2079-89. 2012
    ..containing data from prior to Jan 2008 regarding this issue failed to find a significant association between CYP1A1 Ile462Val variation and oral cancer susceptibility...
  34. ncbi Influence of antioxidants and the CYP1A1 isoleucine to valine polymorphism on the smoking--lung cancer association
    D Ratnasinghe
    Division of Clinical Sciences, National Cancer Institute, NIH, Bethseda, MD, USA
    Anticancer Res 21:1295-9. 2001
    To evaluate the association between CYP1A1 genotype and lung cancer risk and to assess the effect of CYP1A1 genotype and antioxidant supplementation on the smoking--lung cancer relationship we conducted a case-control study nested within ..
  35. ncbi Relationship of tobacco smoking CYP1A1 GSTM1 gene polymorphism and esophageal cancer in Xi'an
    An hui Wang
    Department of Epidemiology, Faculty of Preventive Medicine, Fourth Military Medical University Xi an 710032, Shaanxi Province, China
    World J Gastroenterol 8:49-53. 2002
    To analyze the association of tobacco smoking polymorphism of CYP1A1 (7th exon) and GSTM1 genotype and esophageal cancer(EC) in Xi'an.
  36. ncbi Role of DNA mismatch repair genetic polymorphisms in the risk of childhood acute lymphoblastic leukaemia
    Geraldine Mathonnet
    Service d hématologie oncologie, Centre de cancérologie Charles Bruneau, Centre de Recherche, Hopital Sainte Justine, and Département de Pédiatrie, Universite de Montreal, Montreal, Quebec, Canada
    Br J Haematol 123:45-8. 2003
    ..influence ALL susceptibility, we found that the MLH1 variant Val-219 further increases the risk of GSTM1 null and CYP1A1*2A genotypes [combined odds ratio (OR) = 6.0, P = 0.002] as well as that of CYP2E1*5 (OR = 15.8, P = 0.001)...
  37. ncbi Influence of genetic polymorphisms of CYP1A1 and GSTM1 on the urinary levels of 1-hydroxypyrene
    P Apostoli
    Chair of Industrial Hygiene, Department of Experimental and Applied Medicine, University of Brescia, P le Spedali Civili, 1, Brescia 25123, Italy
    Toxicol Lett 144:27-34. 2003
    ..the influence of the genetic polymorphism of two enzymes involved in the biotransformation of xenobiotics, cytochrome P450 1A1 (CYP1A1) and glutathione-S-transferase M1 (GSTM1), on the urinary levels of 1-hydroxypyrene (1-OH-P) in ..
  38. doi Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility
    Han Chun Chen
    Department of Biochemistry, School of Biological Science and Technology, Central South University, Changsha, Hunan, China
    Eur J Cancer Prev 17:251-8. 2008
    The genetic polymorphisms of biotransformation phase I enzymes, cytochrome P450 (CYP1A1 and CYP2D6), and phase II enzymes, glutathione S-transferase (GSTM1 and GSTT1), were analyzed in 204 healthy persons and 348 leukemia patients, who ..
  39. pmc CYP1A1 gene polymorphisms as a risk factor for pterygium
    Chi Hsien Young
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Mol Vis 16:1054-8. 2010
    Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs)...
  40. ncbi CYP 1A1 polymorphism and risk of lung cancer in relation to tobacco smoking: a case-control study in China
    N Song
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Carcinogenesis 22:11-6. 2001
    The impact of genetic polymorphisms in CYP1A1 on susceptibility to lung cancer has received particular interest in recent years since this enzyme plays a central role in activation of major classes of tobacco carcinogens...
  41. ncbi CYP1A1 m1 and m2 polymorphisms: genetic susceptibility to lung cancer
    Paula Mota
    Instituto de Genetica, Faculdade de Medicina, 3000 Coimbra
    Rev Port Pneumol 16:89-98. 2010
    ..The CYP1A1 gene codifies the phase I enzyme aryl hydrocarbon hydroxilase (AHH) belonging to the cytochrome P450 system that ..
  42. ncbi The GST deletions and NQO1*2 polymorphism confers interindividual variability of response to treatment in patients with acute myeloid leukemia
    Eva Barragan
    Molecular Biology Laboratory, Dpt Medical Pathology, Spain
    Leuk Res 31:947-53. 2007
    ..patients diagnosed with de novo acute myeloid leukemia (AML) to clarify the influence of the genetic polymorphisms CYP1A1*2A, CYP3A4*1B, CYP2E1*5B, del{GSTT1}, del{GSTM1}, and NQO1*2 on disease outcome...
  43. ncbi Cytochrome P4501A1 polymorphism is associated with susceptibility to acute lymphoblastic leukemia in adult Mexican patients
    M P Gallegos-Arreola
    Division de Medicina Molecular, Centro de Investigacion Biomedica de Occidente, Guadalajara, Jalisco, Mexico
    Blood Cells Mol Dis 33:326-9. 2004
    We studied the role of cytochrome P4501A1 (CYP1A1 Val/Val) genotypes in the etiology of acute lymphoblastic leukemia (ALL) in adult Mexican patients...
  44. ncbi Identification of cytochrome P450 1A1 in human brain
    C H Yun
    Department of Biochemistry, Pai Chai University, Taejon, Korea
    Biochem Biophys Res Commun 243:808-10. 1998
    ..We demonstrated for the first time that human brain contains a P450 1A1-dependent metabolism system which seems to be important for understanding the metabolism of endogenous and exogenous compounds...
  45. ncbi [Study on the relationship between polymorphisms of Cyp1A1, GSTM1, GSTT1 genes and the susceptibility to acute leukemia in the general population of Hunan province]
    Qing Xia Liu
    Molecular Biology Research Center, Xiangya School of Medicine, Central South University, Changsha 410078, China
    Zhonghua Liu Xing Bing Xue Za Zhi 26:975-9. 2005
    Based on the distribution of genetic polymorphisms regarding phase I metabolic enzyme cytochrome P450 1A1 (CYP1A1) and phase II metabolic enzymes glutathione S-transferase GSTM1 and GSTT1 genotypes in acute leukemia patients and health ..
  46. doi Polymorphisms in CYP1A1 and ethnic-specific susceptibility to acute lymphoblastic leukemia in children
    Ryan M Swinney
    Department of Pediatrics and Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Epidemiol Biomarkers Prev 20:1537-42. 2011
    ..Previous reports have shown an association between CYP1A1 variants and ALL.
  47. doi Investigations of the posttranslational mechanism of arsenite-mediated downregulation of human cytochrome P4501A1 levels: the role of heme oxygenase-1
    Erin E Bessette
    Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, Albany, NY 12201 0509, USA
    J Biochem Mol Toxicol 23:222-32. 2009
    ..cocontaminant of polycyclic aromatic hydrocarbons (PAHs), diminishes the PAH-mediated upregulation of human CYP1A1, the enzyme that bioactivates PAHs to carcinogenic metabolites...
  48. pmc An association between BPDE-like DNA adduct levels and CYP1A1 and GSTM1 polymorphisma in pterygium
    Jai Nien Tung
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Mol Vis 16:623-9. 2010
    ..Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic ..
  49. pmc Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Hum Mol Genet 20:2071-7. 2011
    ..two sequence variants significantly associated with increased coffee consumption: rs2472297-T located between CYP1A1 and CYP1A2 at 15q24 (P = 5.4 · 10(-14)) and rs6968865-T near aryl hydrocarbon receptor (AHR) at 7p21 (P = 2...
  50. ncbi CYP1A1 and GSTM1 polymorphisms in relation to lung cancer risk in Chinese women
    Xiaohong R Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, Bethesda MD 20892, USA
    Cancer Lett 214:197-204. 2004
    We examined CYP1A1 (I462V) and GSTM1 null polymorphisms in 200 female cases and 144 female controls selected from a population-based case-control study of lung cancer conducted in northeast China, where the rates of lung cancer among ..
  51. ncbi Association of CYP1A1 germ line polymorphisms with mutations of the p53 gene in lung cancer
    K Kawajiri
    Department of Biochemistry, Saitama Cancer Center Research Institute, Japan
    Cancer Res 56:72-6. 1996
    We reported an association of smoking-induced lung cancer susceptibility with the human cytochrome P450 1A1 (CYP1A1) polymorphisms in our previous studies...
  52. doi Lack of significant association between CYP1A1 T3801C polymorphism and breast cancer risk: a meta-analysis involving 25,087 subjects
    Lei Yao
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, People s Republic of China
    Breast Cancer Res Treat 122:503-7. 2010
    ..To date, many publications have evaluated the correlation between cytochrome P450 1A1 (CYP1A1) T3801C polymorphism and breast cancer risk. However, the results remain inconclusive...
  53. ncbi Polymorphisms in CYP1A1 and breast carcinoma risk in a population-based case-control study of Chinese women
    Sonia M Boyapati
    Department of Medicine, Center for Health Services Research, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer 103:2228-35. 2005
    b>Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma.
  54. ncbi Urinary 1-hydroxypyrene level relative to vehicle exhaust exposure mediated by metabolic enzyme polymorphisms
    Chun Yu Chuang
    Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan
    J Occup Health 49:140-51. 2007
    ..12 +/- 0.05 vs. 0.07 +/- 0.03 micromol/mol creatinine). The subjects with the m1/m2 or m2/m2 genotype of CYP1A1 MspI or GSTM1 deficiency had significantly higher urinary 1-OHP levels than those with other CYP1A1 MspI and GSTM1 ..
  55. ncbi The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers
    Bo Chen
    Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, 200032, PR China
    Sci Total Environ 381:38-46. 2007
    ..No influence was found in the association between urinary 1-OHP and other genetic polymorphisms such as CYP1A1, CYP1A2, CYP1B1, CYP2E1, EPHX1, EPHX2 in this population.
  56. ncbi Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps
    Ellen L Goode
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center Seattle, WA, USA
    Carcinogenesis 28:328-41. 2007
    ..We hypothesized that genetic variation in the encoding genes NAT1, NAT2, SULT1A1, SULT1A2, CYP1A1 or EPHX1 is associated with risk of colorectal polyps and interacts with cigarette use or meat intake to modify ..
  57. ncbi Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation
    J Corchero
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Pharmacogenetics 11:1-6. 2001
    ..A human genomic clone from a BAC library, containing both CYP1A1 and CYP1A2 genes, was isolated and sequenced...
  58. ncbi Serum increases CYP1A1 induction by 3-methylcholanthrene
    Quoc Binh N'Guyen
    UMR CNRS 6032, Faculte de Pharmacie, Universite Mediterranee, 27 Boulevard Jean Moulin, FR 13385, Marseille Cedex, France
    Biochem Biophys Res Commun 297:249-54. 2002
    b>CYP1A1 is largely involved in carcinogenesis through the bioactivation of numerous procarcinogens. Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) leads to induction of CYP1A1 via AhR pathway...
  59. ncbi Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia
    Gunay Balta
    Hacettepe University, Faculty of Medicine, Department of Pediatrics, Institute of Child Health and Section of Pediatric Hematology, Ankara, Turkey
    Am J Hematol 73:154-60. 2003
    ..reductase (MTHFR C677T), glutathione S-transferases (GSTM1 and GSTT1 null, GSTP1 Ile105Val), and cytochromes p450 (CYP1A1*2A) genotypes in the etiology of childhood leukemia was simultaneously investigated...
  60. ncbi Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to oral cavity cancer
    Matthias Hahn
    Institute of Pathology, Department of Medicine of the Ruprecht Karls University Heidelberg, Theodor Kutzer Ufer, 68135 Mannheim, Germany
    Oral Oncol 38:486-90. 2002
    ..DNA of 94 Caucasian patients in Germany and 92 healthy German controls to determine genotypes of polymorphisms in CYP1A1, GSTM1 and NAT2. For CYP1A1, the homozygous mutant genotype Val/Val did not occur...
  61. ncbi Genetic polymorphisms of NAD(P)H quinone oxidoreductase, CYP1A1 and microsomal epoxide hydrolase and lung cancer risk in Nanjing, China
    L Yin
    School of Public Health, Southeast University, Nanjing, PR China
    Lung Cancer 33:133-41. 2001
    ..Genetic polymorphisms of NAD(P)H quinone oxidoreductase (NQO1), cytochrome P4501A1 (CYP1A1) and microsomal epoxide hydrolase (HYL1) have been associated with increased lung cancer risk in Asian populations...
  62. ncbi Interaction of cytochrome P4501A1 genotypes with other risk factors and susceptibility to lung cancer
    Parag P Shah
    Developmental Toxicology Division, Industrial Toxicology Research Centre, Lucknow 226001, India
    Mutat Res 639:1-10. 2008
    ..population, the present case-control study attempted to investigate the association of polymorphisms in cytochrome P450 1A1 (CYP1A1) and glutathione-S-transferase M1 (GSTM1) with risk to squamous cell carcinoma of lung malignancy...
  63. ncbi Polymorphisms of drug-metabolizing enzymes and risk of childhood acute lymphoblastic leukemia
    S Pakakasama
    Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Am J Hematol 79:202-5. 2005
    ..7; 95% CI, 1.0, 2.7). In contrast, the GSTT1 null genotype did not show this effect. Our data thus demonstrate that the GSTM1 null genotype might increase the risk of childhood ALL in a Thai population...
  64. ncbi Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years
    E Taioli
    Molecular and Genetic Epidemiology Unit, Ospedale Maggiore IRCCS, Italy
    Int J Epidemiol 32:60-3. 2003
    ..The role of metabolic gene polymorphisms has never been studied in young lung cancer cases. Phase 1 and Phase 2 gene polymorphisms are involved in tobacco carcinogens' metabolism and therefore in lung cancer risk...
  65. ncbi The CYP1A1 genotype may alter the association of meat consumption patterns and preparation with the risk of colorectal cancer in men and women
    Maureen A Murtaugh
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84101, USA
    J Nutr 135:179-86. 2005
    ..with meat preparation methods producing heterocyclic amines or polycyclic aromatic hydrocarbons is modified by the CYP1A1 genotype alone or in combination with the GSTM1 genotype or the NAT2 imputed phenotype...
  66. ncbi Genetic polymorphism of CYP1A1, CYP2D6, GSTM1 and GSTT1 and susceptibility to acute lymphoblastic leukaemia in Indian children
    Thomas Joseph
    Department of Molecular Medicine, Drug Development and Chemoinformatics, Regional Cancer Centre, Thiruvananthapuram, India
    Pediatr Blood Cancer 43:560-7. 2004
    ..These variations could play a role in the risk of developing paediatric acute lymphoblastic leukaemia (ALL) by their varying action on environmental carcinogens...
  67. ncbi Cytochrome P450 1A1 (CYP1A1) T3801C and A2455G polymorphisms in breast cancer risk: a meta-analysis
    Chengwen Chen
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, People s Republic of China
    J Hum Genet 52:423-35. 2007
    The cytochrome P450 1A1 gene (CYP1A1), encoding Phase I metabolic enzymes, appeared to be a candidate gene for breast cancer risk...
  68. ncbi Profile of polymorphisms of drug-metabolising enzymes and the risk of therapy-related leukaemia
    Pascual Bolufer
    Laboratory of Molecular Biology Medical Biopathology, Hospital Universitario La Fe, Valencia, Spain
    Br J Haematol 136:590-6. 2007
    ..We analysed the prevalence of genetic polymorphisms of CYP1A1*2A(T6235C), CYP2E1*5B(C-1019T), CYP3A4*1B(A-290G), del{GSTT1}, del{GSTM1}, NQO1*2(C609T), MTHFR(C677T) and TYMS 2R/..
  69. pmc Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study
    Yu Li
    Department of Epidemiology, School of Public Heath, University of North Carolina, Chapel Hill, North Carolina, USA
    Breast Cancer Res 7:R12-8. 2005
    ..However, two recent studies showed a stronger association among postmenopausal white women with the inducible M2 polymorphism in the cytochrome P450 1A1 (CYP1A1) gene.
  70. ncbi Interaction between CYP1A1 polymorphic variants and dietary exposures influencing ovarian cancer risk
    Kathryn L Terry
    Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:187-90. 2003
    Aromatic hydrocarbon hydroxylase (CYP1A1) is involved in the metabolism of many substrates and the subject of cancer studies. This study examined the association between two polymorphic variants of CYP1A1 and ovarian cancer risk...
  71. ncbi CYP1A1 polymorphism and risk of gynecological malignancy in Japan
    T Sugawara
    Departments of Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Int J Gynecol Cancer 13:785-90. 2003
    ..Estrogens are metabolized by cytochrome P450 1A1 (CYP1A1) and converted into catecholestrogens, which are carcinogens...
  72. ncbi Ovarian cancer risk and polymorphisms involved in estrogen catabolism
    Sarah K Holt
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P O Box 19024 M4 C308, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:481-9. 2007
    ..Subjects were interviewed and genotyped for CYP1A1 m1, m2, m3, and m4; CYP1B1 Arg(48)Gly, Ala(119)Ser, Val(432)Leu, and Asn(453)Ser; COMT Val(158)Met; UGT1A1 A(TA)..
  73. pmc Assessment of interactions between PAH exposure and genetic polymorphisms on PAH-DNA adducts in African American, Dominican, and Caucasian mothers and newborns
    Shuang Wang
    Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 17:405-13. 2008
    ..play an important role in the metabolic activation or detoxification of PAHs, including the cytochrome P450 genes CYP1A1 and CYP1B1 and the glutathione S-transferase (GST) genes GSTM1, and GSTT2...
  74. ncbi CYP1A1 and GSTM1 genetic polymorphisms in lung cancer populations exposed to arsenic in drinking water
    M Adonis
    Laboratorio de Bioquímica y Toxicología Ambiental, Facultad de Medicina, ICBM, Universidad de Chile, Santiago, Chile
    Xenobiotica 35:519-30. 2005
    ....
  75. pmc Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women
    Yu Li
    Department of Epidemiology, School of Public Heath and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Breast Cancer Res 6:R460-73. 2004
    Previous epidemiologic studies suggest that women with variant cytochrome P4501A1 (CYP1A1) genotypes who smoke cigarettes are at increased risk for breast cancer.
  76. ncbi Risk of non-small cell lung cancer and the cytochrome P4501A1 Ile462Val polymorphism
    Jill Everland Larsen
    Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Australia
    Cancer Causes Control 16:579-85. 2005
    The Ile462Val substitution in the cytochrome P450 1A1 gene (CYP1A1) results in increased enzymatic activity...
  77. ncbi Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH
    Maura Lodovici
    Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Cancer Epidemiol Biomarkers Prev 13:1342-8. 2004
    ..The high-risk group included subjects characterized by a combination of increased B(a)P activation [cytochrome P450 1A1 (CYP1A1) MspI and/or exon 7 Ile462Val allele variants and microsomal epoxide hydrolase (mEH) fast activity] ..
  78. ncbi Increased risk for acute myeloid leukaemia in individuals with glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) gene defects
    V R Arruda
    Department of Internal Medicine, State University of Campinas, Campinas, Sao Paulo, Brazil
    Eur J Haematol 66:383-8. 2001
    ..Both the GST mu 1 (GSTM1) and GST theta 1 (GSTT1) genes have a null variant allele in which the entire gene is absent. In this study, we tested whether null genotypes for the GSTM1 and GSTT1 genes altered the risks for MDS, AML and AA...
  79. ncbi An investigation of mammographic density and gene variants in healthy women
    Gertraud Maskarinec
    Cancer Research Center of Hawaii, Honolulu, HI 96813, USA
    Int J Cancer 112:683-8. 2004
    ..Following DNA extraction, samples were analyzed for polymorphisms in the COMT (Val158Met), CYP1A1 (Ile462Val), CYP1B1 (Val432Leu), CYP1A2 (*1F) and CYP17 (T27C) genes using PCR-RFLP...
  80. ncbi Interactions between CYP1A1 polymorphisms and exposure to environmental tobacco smoke in the modulation of lymphocyte bulky DNA adducts and chromosomal aberrations
    Panagiotis Georgiadis
    National Hellenic Research Foundation, Institute of Biological Research and Biotechnology, 48 Vas Constantinou Avenue, Athens 116 35, Greece
    Carcinogenesis 26:93-101. 2005
    b>CYP1A1 plays an important role in the metabolic activation of polycyclic aromatic hydrocarbons (PAH), carcinogenic components of air pollution...
  81. ncbi Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites
    E Seree
    FRE Centre National de la Recherche Scientifique, Faculte de Pharmacie, Marseille, France
    Gastroenterology 127:1436-45. 2004
    b>Cytochrome P450 1A1 catalyzes the degradation of endobiotics (estradiol, fatty acids, and so on) and the bioactivation of numerous environmental procarcinogens, such as arylamines and polycyclic aromatic hydrocarbons, that are found in ..
  82. ncbi Biological monitoring the exposure to polycyclic aromatic hydrocarbons of coke oven workers in relation to smoking and genetic polymorphisms for GSTM1 and GSTT1
    J H van Delft
    Toxicology Division, TNO Nutrition and Food Research Institute, P O Box 360, 3700 AJ, Zeist, The Netherlands
    Ann Occup Hyg 45:395-408. 2001
    ..Also no significant interactions were observed between the various biomarkers.Conclusion: This study shows that in the examined plant, the occupational exposure to PAH does not result in measurable early biological effects..
  83. ncbi CYP1A1 and CYP1B1 polymorphisms and risk of lung cancer among never smokers: a population-based study
    A S Wenzlaff
    Population Studies and Prevention Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Carcinogenesis 26:2207-12. 2005
    ..Polymorphisms within the CYP1A1 gene have been shown to be associated with lung cancer risk, predominantly among Asian populations...
  84. ncbi The influence of genetic polymorphisms in Ahr, CYP1A1, CYP1A2, CYP1B1, GST M1, GST T1 and UGT1A1 on urine 1-hydroxypyrene glucuronide concentrations in healthy subjects from Rio Grande do Sul, Brazil
    Christian C Abnet
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 320, MSC 7232, Rockville, MD 20852, USA
    Carcinogenesis 28:112-7. 2007
    ..010. Variants in aryl hydrocarbon receptor (Ahr) (rs4986826), CYP1A1 (rs1799814) and CYP1A2 (rs2069514) were also, although less strongly, associated with changes in urine 1-OHPG ..
  85. ncbi CYP1A1 and GSTM1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis
    Xiuquan Shi
    Department of Epidemiology and Health Statistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
    Lung Cancer 59:155-63. 2008
    Genetic polymorphisms of cytochrome p450 (CYP1A1) and glutathione S-transferase M1 (GSTM1) genes are thought to have significant effects on the metabolism of environmental carcinogens and thus on cancer risk, but the reported results are ..
  86. ncbi A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility
    I Cascorbi
    Institute of Clinical Pharmacology, University Clinic Charite, Humboldt University of Berlin, Germany
    Cancer Res 56:4965-9. 1996
    This study reports a C-->A transversion at position 4887 in exon 7 of cytochrome P4501A1 (CYP1A1), resulting in a threonine-asparagine exchange in codon 461...
  87. ncbi Association of CYP1A1 polymorphisms with breast cancer in North Indian women
    Neetu Singh
    Genotoxicity Laboratory, Toxicology Division, Central Drug Research Institute, Lucknow 226 001, Uttar Pradesh, India
    Oncol Res 16:587-97. 2007
    ..In the present case control study four CYP1A1 gene polymorphisms, m1 (T6235C), m2 (A4889G), m3 (T5639C), and m4 (C4887A) were studied for their association with ..
  88. ncbi Genetic polymorphisms of biotransformation enzymes: allele frequencies in the population of the Czech Republic
    J Sarmanova
    Biotransformations Group, Center of Occupational Diseases, National Institute of Public Health, Praha, Czech Republic
    Pharmacogenetics 10:781-8. 2000
    ..fragment length polymorphism based genotyping assays were used to determine the frequency of polymorphisms in CYP1A1 (3'-flanking region), CYP2E1 (5'-flanking region and intron 6), EPHX (exon 3 and exon 4), GSTM1 (deletion), GSTP1 (..
  89. ncbi Variable drug metabolism genes in Arab population
    R Bu
    King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Pharmacogenomics J 4:260-6. 2004
    ..We used PCR analysis to catalog the frequencies of alleles and genotypes for CYP1A1, NAT2, GSTs, MTHFR, MTR (MS) and NQO*1 in Arabs...
  90. ncbi Evidence of gene gene interactions in lung carcinogenesis in a large pooled analysis
    Paolo Vineis
    Epidemiology Department, Univerisitá degli Studi di Torino, 10126 Torino, Italy
    Carcinogenesis 28:1902-5. 2007
    ..risk of cancer, we have studied the cumulative effect on lung cancer risk of variants in three metabolic genes, CYP1A1, GSTM1 and GSTT1, which are involved in the metabolism of the tobacco smoke constituents and environmental ..
  91. ncbi Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition
    Antonio Agudo
    Unit of Epidemiology, Catalan Institute of Oncology, L Hospitalet de Llobregat, Av Gran Via s n km 2 7, 08907 Barcelona, Spain
    Cancer Epidemiol Biomarkers Prev 15:2427-34. 2006
    ..results of a study looking at the association between risk of gastric adenocarcinoma and polymorphisms in genes CYP1A1, CYP1A2, EPHX1, and GSTT1...
  92. ncbi Transcriptional activation of CYP2C9, CYP1A1, and CYP1A2 by hepatocyte nuclear factor 4alpha requires coactivators peroxisomal proliferator activated receptor-gamma coactivator 1alpha and steroid receptor coactivator 1
    Celia P Martinez-Jimenez
    Unidad de Hepatologia Experimental, Centro de Investigacion, Hospital La Fe, Avenida de Campanar, 21, 46009 Valencia, Spain
    Mol Pharmacol 70:1681-92. 2006
    ..transfection of PGC1alpha in human hepatoma cells caused a significant dose-dependent increase in CYP2C9, CYP1A1, and CYP1A2 and in the positive control CYP7A1...
  93. ncbi Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: a case-control study in the Grampian region of Scotland
    Julian Little
    Epidemiology Group, Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, UK
    Int J Cancer 119:2155-64. 2006
    Cytochrome P-450 CYP1A1 is involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs) that are derived from meat intake and tobacco smoking...
  94. ncbi GSTM1 and CYP1A1 polymorphisms, tobacco, air pollution, and lung cancer: a study in rural Thailand
    Paola Pisani
    Descriptive Epidemiology Group, IARC, Lyons, France
    Cancer Epidemiol Biomarkers Prev 15:667-74. 2006
    ..The presence of several large open-cast coal mines from 1955 close to electricity-generating plants was a particular focus of concern...
  95. ncbi A common regulatory region functions bidirectionally in transcriptional activation of the human CYP1A1 and CYP1A2 genes
    Rika Ueda
    Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki aoba 6 3, Aoba ku, Sendai 980 8578, Japan
    Mol Pharmacol 69:1924-30. 2006
    The human CYP1A1 and CYP1A2 genes on chromosome 15 are orientated head-to-head and are separated by a 23-kilobase (kb) intergenic spacer region...
  96. ncbi Joint effects of the CYP1A1 MspI, ERalpha PvuII, and ERalpha XbaI polymorphisms on the risk of breast cancer: results from a population-based case-control study in Shanghai, China
    Yueping Shen
    School of Radiation Medicine and Public Health, Soochow University, Suzhou, PR China
    Cancer Epidemiol Biomarkers Prev 15:342-7. 2006
    ..We examined whether CYP1A1 MspI, ERalpha PvuII, and ERalpha XbaI genetic polymorphisms could increase the risk of breast cancer among Chinese ..
  97. ncbi EPHX1 polymorphisms and the risk of lung cancer: a HuGE review
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Epidemiology 17:89-99. 2006
    ..The aim of this study is to review and summarize the available molecular epidemiologic studies of lung cancer and EPHX1...
  98. ncbi CYP1A1 *2B and *4 polymorphisms are associated with lung cancer susceptibility in Mexican patients
    M P Gallegos-Arreola
    Molecular Genetics Laboratory, Division of Molecular Medicine, Centro de Investigacion Biomedica de Occidente, Guadalajara, Jalisco Mexico
    Int J Biol Markers 23:24-30. 2008
    CYP1A1 is a gene involved in the high aryl hydrocarbon hydroxylase -inducible phenotype, which is a genetically-determined variation among individuals that has been associated with lung cancer risk...
  99. ncbi Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P450IA1 gene
    K Kawajiri
    Department of Biochemistry, Saitama Cancer Center Research Institute, Japan
    FEBS Lett 263:131-3. 1990
    ..This is the first report to identify the genetically high risk individuals to lung cancer at the gene level...
  100. ncbi CYP1A1 gene polymorphism and risk of epithelial ovarian neoplasm
    Dilek Aktas
    Department of Genetics, Hacettepe University Medical School, 06100, Sihhiye, Ankara, Turkey
    Gynecol Oncol 86:124-8. 2002
    ..Previous studies suggest that estrogens are involved in the etiology of ovarian cancer. The cytochrome P450 1A1 (CYP1A1) gene polymorphism may play role in the development of epithelial ovarian neoplasm by ..
  101. ncbi The effect of relevant genotypes on PAH exposure-related biomarkers
    Terhi Kuljukka-Rabb
    Institute of Occupational Health, FIN 00250 Helsinki, Finland
    J Expo Anal Environ Epidemiol 12:81-91. 2002
    ..Urinary mutagenicity was measured using the Ames test. CYP1A1, microsomal epoxide hydrolase (mEH), and glutathione S-transferase (GST) genotypes were analyzed by polymerase ..

Research Grants113 found, 100 shown here

  1. Molecular Analysis of Esophageal Cancer Survival
    Matthew Kulke; Fiscal Year: 2007
    ..the association between overall survival and the presence of specific genetic polymorphisms (GSTP1, GSTM1, GSTT1, CYP1A1, CYP3A5, p53, XRCC1 and ERCC2) in patients with esophageal cancer...
  2. AHR signaling in Mammalian and Non-Mammalian Models
    MARK HAHN; Fiscal Year: 2007
    ..and others have recently characterized three members of the vertebrate AHR family: AHR1, AHR2, and AHR Repressor (AHRR), and we have found that there is additional AHR diversity in fish, with up to 5 genes per species...
  3. CARCINOGEN ACTIVATION AND SCREENING IN VARIANT CELLS
    Oliver Hankinson; Fiscal Year: 2004
    ..The AHR/ARNT dimer activates transcription of CYP1A1 and certain other genes. Induction of CYP1A1 is involved in carcinogenesis by benzo(a) pyrene...
  4. Regulation of cyp1a1 by Ah Receptor and NFkB Interaction
    Yanan Tian; Fiscal Year: 2009
    ..for the long-standing observation that inflammatory cytokines and lipopolysaccharide suppress AhR-regulated cytochrome P450 1A1/1A2 and decrease capacity of xenobiotic (including clinical drugs) metabolism (J. Biol. Chem. 276,39638)...
  5. MOLECULAR MECHANISMS OF DIOXIN ACTION
    Alvaro Puga; Fiscal Year: 2002
    ..with the Ah receptor nuclear translocator protein ARNT, mediates the transcriptional activation of genes in the CYP1 family of cytochrome P450 monooxygenases...
  6. INTERACTION BETWEEN AH RECEPTOR AND NF-KB PATHWAYS
    Yanan Tian; Fiscal Year: 2002
    ..of AhR by NF-kB also offers an underlying mechanism for cytokine-induced suppression of cytochrome P450s (such as CYP1A1, 1A2)...
  7. MOLECULAR MECHANISMS OF DIOXIN ACTION
    Alvaro Puga; Fiscal Year: 2007
    ..However, activation of the CYP1A1, CYP1A2 and CYP1 B1 genes, although one of the best characterized effects of Ah receptor activation by TCDD, does ..
  8. Validation of Biomarkers in Humans Exposed to PAHs
    Qingshan Qu; Fiscal Year: 2004
    ..In addition, the polymorphisms of genes, including CYP1A1, microsomal epoxide hydrolase (mEH), GSTM1, and p53 genes, will be identified to assess gene-environment ..
  9. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O apos NEILL; Fiscal Year: 2010
    ..DNA samples from mother and infant will be used to type genetic polymorphisms (CYP1A1, GSTM1, GSTT1, GSTP1, Xrcc1, XPD) relevant to the hypothesized mechanisms...
  10. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE O NEILL; Fiscal Year: 2009
    ..DNA samples from mother and infant will be used to type genetic polymorphisms (CYP1A1, GSTM1, GSTT1, GSTP1, Xrcc1, XPD) relevant to the hypothesized mechanisms...
  11. A BREATH TEST FOR LUNG CANCER
    Michael Phillips; Fiscal Year: 2007
    ..Alkanes and their metabolites are metabolized rapidly by high risk cytochrome P450 phenotypes (e.g., CYP1A1, CYP1A2 and CYP2E1) whose activity is induced by polycyclic aromatic hydrocarbons in tobacco smoke...
  12. Cytochrome-P-450 genes in pathobiology of endometrial cancer
    Rajvir Dahiya; Fiscal Year: 2007
    The main goal of this project is to investigate whether the cytochrome P4501A1 (CYP1A1) and cytochrome P4501B1 (CYP1B1) genes are risk factors for pathobiology of endometrial cancer...
  13. Cytochrome-P-450 genes in pathobiology of endometrial cancer
    Rajvir Dahiya; Fiscal Year: 2009
    The main goal of this project is to investigate whether the cytochrome P4501A1 (CYP1A1) and cytochrome P4501B1 (CYP1B1) genes are risk factors for pathobiology of endometrial cancer...
  14. Molecular mechanisms of cytochrome P4501A regulation by hyperoxia
    Bhagavatula Moorthy; Fiscal Year: 2010
    ..ii) To test the hypothesis that humanized CYP1A1 mice [hCYP1A1-Cyp1a1 (-/-)], or hCYP1A1_1A2-Cyp1a1/1a2 (-/-)] mice on will be more tolerant to hyperoxic injury, ..
  15. Toxicological Control Mechanisms of Human CYP1A2
    LINDA QUATTROCHI; Fiscal Year: 2004
    ..CYP 1 A, one of the CYP subfamilies in vertebrates consisting of two members, CYP1A1 and CYP1A2, catalyzes the metabolism of such environmental chemicals as polycyclic aromatic hydrocarbons and ..
  16. Early Disease Biomarkers of PCB-exposed Human Population
    Sisir Dutta; Fiscal Year: 2007
    ..PCBs and metabolites of PCBs that have been isolated from human blood and tissues, and the gene cytochrome P450 (CYP1A1), which mediates production of OH-PCB by oxidative metabolism, has been found to be 65-fold increased by PCB-77 in ..
  17. CARCINOGEN ACTIVATION AND SCREENING IN VARIANT CELLS
    Oliver Hankinson; Fiscal Year: 1990
    ..The principal enzyme activity involved is cytochrome P1-450 dependent aryl hydrocarbon hydroxylase (AHH). PAH's, in addition to being substrates, also induce P1-450...
  18. Role of hepatic and pulmonary P4501A enzymes in neonatal hyperoxic tissue injury
    XANTHI IOANNA COUROUCLI; Fiscal Year: 2010
    ..the hypothesis that prenatal or postnatal exposure of wild type (WT) (C57BL/6J) mice to the cytochrome P4501A1 (CYP1A1) inducer beta-naphthoflavone (BNF) will result in attenuation or potentiation, respectively, of acute lung and ..
  19. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..g. grilled foods & cigarette smoke. Cytochromes P450 1A1 & 1B1 (CYP1A1, CYP1B1) are responsible for the metabolism of numerous PAHs, the prototype of which is benzo[a]pyrene (BaP)...
  20. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..g. grilled foods & cigarette smoke. Cytochromes P450 1A1 & 1B1 (CYP1A1, CYP1B1) are responsible for the metabolism of numerous PAHs, the prototype of which is benzo[a]pyrene (BaP)...
  21. AHR signaling in Mammalian and Non-Mammalian Models
    Mark E Hahn; Fiscal Year: 2011
    ..An inhibitor of AHR transcriptional activation function, AHR repressor (AHRR), has been identified, but its role in regulating AHR signaling remains enigmatic, and possible functions beyond ..
  22. AHR signaling in Mammalian and Non-Mammalian Models
    Mark E Hahn; Fiscal Year: 2010
    ..An inhibitor of AHR transcriptional activation function, AHR repressor (AHRR), has been identified, but its role in regulating AHR signaling remains enigmatic, and possible functions beyond ..
  23. ENDOGENOUS CYP1B1 SUBSTRATES AS AHR LIGANDS
    Craig Marcus; Fiscal Year: 2003
    ..II) The toxicological significance of prolonged Ahr-induced activation of CYP1A1, 1B1, and 1A2 expression many also be an important aspect PAH toxicity...