Cyp1A1

Summary

Gene Symbol: Cyp1A1
Description: cytochrome P450 family 1 subfamily A member 1
Alias: AHH, AHRR, CP11, CYP1, CYPIA1, P1-450, P450-C, P450DX, cytochrome P450 1A1, aryl hydrocarbon hydroxylase, cytochrome P1-450, dioxin-inducible, cytochrome P450 form 6, cytochrome P450, family 1, subfamily A, polypeptide 1, cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1, cytochrome P450-C, cytochrome P450-P1, flavoprotein-linked monooxygenase, xenobiotic monooxygenase
Species: human
Products:     Cyp1A1

Top Publications

  1. Gallegos Arreola M, Figuera Villanueva L, Troyo Sanroman R, Morgan Villela G, Puebla Pérez A, Flores Marquez M, et al. CYP1A1 *2B and *4 polymorphisms are associated with lung cancer susceptibility in Mexican patients. Int J Biol Markers. 2008;23:24-30 pubmed
    CYP1A1 is a gene involved in the high aryl hydrocarbon hydroxylase -inducible phenotype, which is a genetically-determined variation among individuals that has been associated with lung cancer risk...
  2. Wright C, Larsen J, Colosimo M, Barr J, Chen L, McLachlan R, et al. Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in nonsmall cell lung cancer. Eur Respir J. 2010;35:152-9 pubmed publisher
    ..Phase I enzymes, including cytochrome P(450), family 1, subfamily A, polypeptide 1 (CYP1A1), are involved in the activation of carcinogens, such as polycyclic aromatic hydrocarbons, to reactive ..
  3. Ghisari M, Long M, Bonefeld Jørgensen E. Genetic polymorphisms in CYP1A1, CYP1B1 and COMT genes in Greenlandic Inuit and Europeans. Int J Circumpolar Health. 2013;72:21113 pubmed publisher
    ..The aim of this study was to determine and compare the genotype and allele frequencies of the cytochrome P450 CYP1A1 Ile462Val (rs1048943), CYP1B1 Leu432Val (rs1056836) and catechol-O-methyltransferase COMT Val158Met (rs4680) in ..
  4. Zhuo X, Zhao H, Chang A, Ye H, Zhou Y, Song Y, et al. Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated meta-analysis including 1,515 cases and 2,233 controls. Tumour Biol. 2012;33:2079-89 pubmed publisher
    ..containing data from prior to Jan 2008 regarding this issue failed to find a significant association between CYP1A1 Ile462Val variation and oral cancer susceptibility...
  5. Zhuo W, Wang Y, Zhuo X, Zhu B, Zhu Y, Chen Z. Polymorphisms of CYP1A1 and GSTM1 and laryngeal cancer risk: evidence-based meta-analyses. J Cancer Res Clin Oncol. 2009;135:1081-90 pubmed publisher
    Previous evidence implicates CYP1A1 and GSTM1 polymorphisms as risk factors for various cancers...
  6. Cheng S, Yu C, Yang P. Genetic polymorphisms of cytochrome p450 and matrix metalloproteinase in chronic obstructive pulmonary disease. Biochem Genet. 2009;47:591-601 pubmed publisher
    ..4 (95% CI 1.1-5.9). No differences were observed in the frequency of polymorphic genotypes in CYP1A1, 1A2, MMP-1 and -3...
  7. Yang S, Jia C, Zhu H, Han S. CYP1A1 Ile462Val polymorphism and cervical cancer: evidence from a meta-analysis. Tumour Biol. 2012;33:2265-72 pubmed publisher
    Many publications have evaluated the correlation between Cytochrome P450 1A1 (CYP1A1) Ile462Val polymorphism and cervical cancer risk, but the results remain inconclusive...
  8. Mrozikiewicz P, Grzeskowiak E, Seremak Mrozikiewicz A, Bogacz A, Barlik M, Semczuk A, et al. Importance of CYP1A1 polymorphism and its transcriptional regulation in ovarian and endometrial cancer. Ginekol Pol. 2011;82:925-32 pubmed
    ..and estron) to intermediate products (2-, 4-hydroxyestradiol and 2-, 4-hydroxyestrone) including CYP1A1 that catalyses hydroxylation to 2-hydroxyestrogens in the endometrium...
  9. Jin J, Hu Y, Niu Y, Yang G, Wu Y, Leng W, et al. CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: a meta-analysis. World J Gastroenterol. 2011;17:260-6 pubmed publisher
    To study the relation between CYP1A1 Ile462Val polymorphism and colorectal cancer risk by meta-analysis...

More Information

Publications78

  1. Zhang J, Deng J, Zhang C, Lu Y, Liu L, Wu Q, et al. Association of GSTT1, GSTM1 and CYP1A1 polymorphisms with susceptibility to systemic lupus erythematosus in the Chinese population. Clin Chim Acta. 2010;411:878-81 pubmed publisher
    GSTT1, GSTM1, CYP1A1 are enzymes responsible for the detoxification of the toxicant which may be involved in the development of systemic lupus erythematosus (SLE)...
  2. Messaros B, Rossano M, Liu G, Diamond M, Friderici K, Nummy Jernigan K, et al. Negative effects of serum p,p'-DDE on sperm parameters and modification by genetic polymorphisms. Environ Res. 2009;109:457-64 pubmed publisher
    ..Serum was analyzed for organochlorines (OC) and DNA for polymorphisms in GSTM1, GSTT1, GSTP1 and CYP1A1. Men with each sperm parameter considered low by WHO criteria (concentration <20million/mL, motility <50%, ..
  3. Choi Y, An S, Lee E, Kim K, Choi S, Kim J, et al. CYP1A1 is a target of miR-892a-mediated post-transcriptional repression. Int J Oncol. 2012;41:331-6 pubmed publisher
    b>Cytochrome P450 1A1 (CYP1A1) is a member of the cytochrome p450 enzyme family, which is involved in the metabolisms of carcinogenic metabolites, such as benzo(a)pyrene...
  4. Gutman G, Morad T, Peleg B, Peretz C, Bar Am A, Safra T, et al. CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer. Int J Gynecol Cancer. 2009;19:1300-2 pubmed publisher
    To assess the frequency distribution of the CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer. Forty-three Israeli Jewish women with cervical cancer and 123 healthy Israeli Jewish women were assessed...
  5. Wang G, Hou J, Ma L, Xie J, Yin J, Xu D, et al. Risk factor for clear cell renal cell carcinoma in Chinese population: a case-control study. Cancer Epidemiol. 2012;36:177-82 pubmed publisher
    ..Genetic polymorphisms of cytochrome P450 mono-oxygenase (CYP1A1: 6235T>C, 4889A>G, and 4887C>A), glutathione S-transferase (GSTP1: 342A>G), and N-acetyltransferase (..
  6. Lee K, Kang D, Clapper M, Ingelman Sundberg M, Ono Kihara M, Kiyohara C, et al. CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations. Cancer Epidemiol Biomarkers Prev. 2008;17:1120-6 pubmed publisher
    To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] and deletion of GSTM1 and GSTT1 in lung cancer development in Asian populations, a pooled analysis was conducted on 13 existing studies included in Genetic ..
  7. Zhuo X, Zhao H, Chang A, Zhou Y, Zhang G, Song Y, et al. Quantitative assessment of CYP1A1*2A variations with oral carcinoma susceptibility: evidence from 1,438 cases and 2,086 controls. Cancer Invest. 2012;30:552-9 pubmed
    Published evidence concerning association of CYP1A1*2A (MspI) variation with oral carcinoma risk has generated controversial results...
  8. Sutherland M, Gill J, Loadman P, Laye J, Sheldrake H, Illingworth N, et al. Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder. Mol Cancer Ther. 2013;12:27-37 pubmed publisher
    We identify cytochrome P450 1A1 (CYP1A1) as a target for tumor-selective drug development in bladder cancer and describe the characterization of ICT2700, designed to be metabolized from a prodrug to a potent cytotoxin selectively by ..
  9. Young C, Lo Y, Tsai Y, Shih T, Lee H, Cheng Y. CYP1A1 gene polymorphisms as a risk factor for pterygium. Mol Vis. 2010;16:1054-8 pubmed
    Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs)...
  10. Zhang Y, Tan L, Zhang X, Wei H, Xiong H, Hu Q. Meta-analysis of cytochrome P4501A1 MspI gene polymorphism and childhood acute leukemia. Biomed Environ Sci. 2011;24:683-7 pubmed publisher
    To investigate the relationship between cytochrome P4501A1 (CYP1A1) Msp I gene polymorphism and childhood acute leukemia (AL)...
  11. Yu L, Sun L, Jiang Y, Lu B, Sun D, Zhu L. Interactions between CYP1A1 polymorphisms and cigarette smoking are associated with the risk of hepatocellular carcinoma: evidence from epidemiological studies. Mol Biol Rep. 2012;39:6641-6 pubmed publisher
    The Cytochrome P-450 1A1 (CYP1A1) gene has been implicated in the etiology of hepatocellular carcinoma (HCC). However, the results have been inconsistent...
  12. Ociepa Zawal M, Rubis B, Filas V, Breborowicz J, Trzeciak W. Studies on CYP1A1, CYP1B1 and CYP3A4 gene polymorphisms in breast cancer patients. Ginekol Pol. 2009;80:819-23 pubmed
    The role of CYP1A1, CYP1B1 and CYP3A4 polymorphism in pathogenesis of breast cancer has not been fully elucidated...
  13. Mota P, Moura D, Vale M, Coimbra H, Carvalho L, Regateiro F. CYP1A1 m1 and m2 polymorphisms: genetic susceptibility to lung cancer. Rev Port Pneumol. 2010;16:89-98 pubmed
    ..The CYP1A1 gene codifies the phase I enzyme aryl hydrocarbon hydroxilase (AHH) belonging to the cytochrome P450 system that ..
  14. Taspinar M, Aydos S, Sakiragaoglu O, Duzen I, Yalcinkaya A, Oztuna D, et al. Impact of genetic variations of the CYP1A1, GSTT1, and GSTM1 genes on the risk of coronary artery disease. DNA Cell Biol. 2012;31:211-8 pubmed publisher
    ..In this study we investigated the effects of genetic polymorphisms of the CYP1A1*2C, GSTT1, and GSTM1 enzymes on CAD risk in a Turkish population...
  15. Ji Y, Wang Q, Suo L. CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lung squamous carcinoma and smokers: a meta-analysis. PLoS ONE. 2012;7:e43397 pubmed publisher
    Many studies have examined the association between the CYP1A1 Ile462Val gene polymorphisms and lung cancer risk in various populations, but their results have been inconsistent...
  16. Yeh C, Sung F, Kuo L, Hsu W, Chu H. Polymorphisms of cytochrome P450 1A1, cigarette smoking and risk of coronary artery disease. Mutat Res. 2009;667:77-81 pubmed publisher
    ..b>Cytochrome P450 1A1 (CYP1A1) is a key enzyme that metabolizes the cigarette toxin relevant to smoking-induced atherogenesis...
  17. Shaik A, Jamil K, Das P. CYP1A1 polymorphisms and risk of prostate cancer: a meta-analysis. Urol J. 2009;6:78-86 pubmed
    Two common polymorphisms in cytochrome P450; family 1, subfamily A, polypeptide 1 (CYP1A1); have been implicated as a risk factor of prostate cancer, but individual studies have been inconclusive or controversial...
  18. Han G, Ma Y, Liu P, Wei X, Zhang X, Zhu F. Quantitative synthesis of the association between the cytochrome P450 1A1 Ile462Val polymorphism and prostate cancer risk. Tumour Biol. 2013;34:1511-6 pubmed publisher
    The association between the cytochrome P450 1A1 (CYP1A1) Ile462Val polymorphism and prostate cancer risk remains inconclusive owing to the conflicting findings from previous studies...
  19. Liu L, Wu G, Xue F, Li Y, Shi J, Han J, et al. Functional CYP1A1 genetic variants, alone and in combination with smoking, contribute to development of head and neck cancers. Eur J Cancer. 2013;49:2143-51 pubmed publisher
    b>CYP1A1 plays an essential role in pathogenesis of head and neck cancers. Functional CYP1A1 Ile462Val and MspI single nucleotide polymorphisms (SNP) are considered to have significant effects on risk of head and neck cancers...
  20. Cote M, Yoo W, Wenzlaff A, Prysak G, Santer S, Claeys G, et al. Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. Carcinogenesis. 2009;30:626-35 pubmed publisher
    ..Eleven SNPs in 10 different genes were examined in relation to risk: CYP1A1 Msp1, CYP1A1 Ile462Val, CYP1B1 Leu432Val, CYP17, CYP19A1, XRCC1 Gln399Arg, COMT Val158Met, NQO1 Pro187Ser, GSTM1, ..
  21. Delpisheh A, Brabin L, Topping J, Reyad M, Tang A, Brabin B. A case-control study of CYP1A1, GSTT1 and GSTM1 gene polymorphisms, pregnancy smoking and fetal growth restriction. Eur J Obstet Gynecol Reprod Biol. 2009;143:38-42 pubmed publisher
    To determine the role of maternal CYP1A1, GSTT1, and GSTM1 metabolic gene polymorphisms in modulating the association between pregnancy smoking exposure and fetal growth restriction...
  22. Kumar M, Agarwal S, Goel S. Lung cancer risk in north Indian population: role of genetic polymorphisms and smoking. Mol Cell Biochem. 2009;322:73-9 pubmed publisher
    ..The polymorphic genes explored were CYP1A1, GSTM1, GSTP1 and GSTT1 using techniques of Polymerase chain reaction (PCR), Restriction Fragment Length ..
  23. Walsh A, Szklarz G, Scott E. Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism. J Biol Chem. 2013;288:12932-43 pubmed publisher
    ..b>CYP1A1 is particularly well known for its ability to biotransform polycyclic aromatic hydrocarbons, such as benzo[a]..
  24. Hussein A, Pasha H, El Shahat H, Gad D, Toam M. CYP1A1 gene polymorphisms and smoking status as modifier factors for lung cancer risk. Gene. 2014;541:26-30 pubmed publisher
    ..The aim of this work was to identify the correlation between CYP1A1 m1 and m2 polymorphisms and lung cancer risk and figure its interactions with smoking as genetic modifiers in the ..
  25. Saeed H, Alanazi M, Nounou H, Salaby M, Semlali A, Azzam N, et al. Cytochrome P450 1A1, 2E1 and GSTM1 gene polymorphisms and susceptibility to colorectal cancer in the Saudi population. Asian Pac J Cancer Prev. 2013;14:3761-8 pubmed
    ..The aim of the present study was to investigate contributions of CYP1A1, CYP2E1, and GSTM1 gene polymorphisms...
  26. Wang D, Su M, Tian D, Liang S, Zhang J. Associations between CYP1A1 and CYP2E1 polymorphisms and susceptibility to esophageal cancer in Chaoshan and Taihang areas of China. Cancer Epidemiol. 2012;36:276-82 pubmed publisher
    ..By using gel-based DNA microarray genotyping method, four cancer-related polymorphisms including CYP1A1 m2, CYP1A1 m4, CYP2E1 Pst I and CYP2E1 Rsa I were studied with 565 (CYP1A1) or 482 (CYP2E1) cases and 468 (CYP1A1) ..
  27. Sergentanis T, Economopoulos K, Choussein S, Vlahos N. Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and cervical cancer risk: a meta-analysis. Mol Biol Rep. 2012;39:6647-54 pubmed publisher
    ..aims to examine whether the genotype status of MspI and Ile462Val polymorphisms in Cytochrome-P450 1A1 (CYP1A1) is associated with cervical cancer risk...
  28. Siddarth M, Datta S, Ahmed R, Banerjee B, Kalra O, Tripathi A. Association of CYP1A1 gene polymorphism with chronic kidney disease: a case control study. Environ Toxicol Pharmacol. 2013;36:164-70 pubmed publisher
    b>CYP1A1 is an important xenobiotic metabolizing enzyme, present in liver and kidney. Expression of CYP1A1 enzyme increases manifold when kidney cells are exposed to nephrotoxins/chemicals leading to oxidative stress-induced cell damage...
  29. Yarosh S, Kokhtenko E, Starodubova N, Churnosov M, Polonikov A. Smoking status modifies the relation between CYP1A1*2C gene polymorphism and idiopathic male infertility: the importance of gene-environment interaction analysis for genetic studies of the disease. Reprod Sci. 2013;20:1302-7 pubmed publisher
    The study was designed to investigate the associations of polymorphisms Ile462Val and 3801T>C of the cytochrome P450 1A1 (CYP1A1) gene with idiopathic male infertility (IMI) and to assess the impact of smoking status on the ..
  30. Kasai S, Ishigaki T, Takumi R, Kamimura T, Kikuchi H. Beta-catenin signaling induces CYP1A1 expression by disrupting adherens junctions in Caco-2 human colon carcinoma cells. Biochim Biophys Acta. 2013;1830:2509-16 pubmed
    ..Calcium depletion induced both nuclear translocation of the Ah receptor, and increased expression of CYP1A1 and Slug mRNAs in Caco-2 cells...
  31. Luo Y, Wen X, Ding P, He Y, Xie C, Liu T, et al. Interaction between maternal passive smoking during pregnancy and CYP1A1 and GSTs polymorphisms on spontaneous preterm delivery. PLoS ONE. 2012;7:e49155 pubmed publisher
    ..the risk of spontaneous PTD and to explore the potential interaction of the single or joint gene polymorphism of CYP1A1 and GSTs with maternal passive smoking on the risk of spontaneous PTD...
  32. Ozturk T, Kahraman O, Toptas B, Kisakesen H, Cakalir C, Verim L, et al. The effect of CYP1A1 and GSTM1 gene polymorphisms in bladder cancer development in a Turkish population. In Vivo. 2011;25:663-8 pubmed
    The aim of this study was to investigate a possible association of the CYP1A1 Ile462Val and GSTM1 null polymorphisms with the risk of developing bladder cancer in a Turkish population...
  33. Swinney R, Beuten J, Collier A, Chen T, Winick N, Pollock B, et al. Polymorphisms in CYP1A1 and ethnic-specific susceptibility to acute lymphoblastic leukemia in children. Cancer Epidemiol Biomarkers Prev. 2011;20:1537-42 pubmed publisher
    ..Previous reports have shown an association between CYP1A1 variants and ALL...
  34. Wang Q, Li H, Tao P, Wang Y, Yuan P, Yang C, et al. Soy isoflavones, CYP1A1, CYP1B1, and COMT polymorphisms, and breast cancer: a case-control study in southwestern China. DNA Cell Biol. 2011;30:585-95 pubmed publisher
    b>CYP1A1, CYP1B1, and COMT are key enzymes involved in estrogen metabolism. Soy isoflavones, phytoestrogens found in soy foods, may modify the activity of these enzymes...
  35. Aydos S, Taspinar M, Sunguroglu A, Aydos K. Association of CYP1A1 and glutathione S-transferase polymorphisms with male factor infertility. Fertil Steril. 2009;92:541-7 pubmed publisher
    ..To examine whether a relationship exists between genetic polymorphisms of glutathione S-transferase (GST) M1 and T1, CYP1A1(*)2C, and male factor infertility. Genetic polymorphism analysis, case-control study...
  36. . Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. Breast Cancer Res Treat. 2010;119:463-74 pubmed publisher
    ..Twenty-eight polymorphisms in eight genes of phase I (CYP1A1, CYP1A2, CYP1B1, CYP2C9, CYP2C19, CYP3A4, CYP3A5, CYP3A7) and nine genes of phase II enzymes (COMT, GSTM1, GSTM3, ..
  37. Sulem P, Gudbjartsson D, Geller F, Prokopenko I, Feenstra B, Aben K, et al. Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption. Hum Mol Genet. 2011;20:2071-7 pubmed publisher
    ..two sequence variants significantly associated with increased coffee consumption: rs2472297-T located between CYP1A1 and CYP1A2 at 15q24 (P = 5.4 · 10(-14)) and rs6968865-T near aryl hydrocarbon receptor (AHR) at 7p21 (P = 2...
  38. Klinchid J, Chewaskulyoung B, Saeteng S, Lertprasertsuke N, Kasinrerk W, Cressey R. Effect of combined genetic polymorphisms on lung cancer risk in northern Thai women. Cancer Genet Cytogenet. 2009;195:143-9 pubmed publisher
    ..genetic susceptibility genes and their association with lung cancer were examined in a northern Thai population: CYP1A1 (MspI), CYP1A1 (Ile462Val), CYP2E1 (PstI), CYP2E1 (DraI), GSTM1, GSTT1, MPO (AciI), OGG1 (Ser326Cys), TP53 (..
  39. Sergentanis T, Economopoulos K, Choussein S, Vlahos N. Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and ovarian cancer risk: a meta-analysis. Mol Biol Rep. 2012;39:9921-30 pubmed
    ..aims to examine whether the genotype status of MspI, Ile462Val, and Thr461Asn polymorphisms in Cytochrome P450 1A1 (CYP1A1) is associated with ovarian cancer risk...
  40. Yao L, Yu X, Yu L. Lack of significant association between CYP1A1 T3801C polymorphism and breast cancer risk: a meta-analysis involving 25,087 subjects. Breast Cancer Res Treat. 2010;122:503-7 pubmed publisher
    ..To date, many publications have evaluated the correlation between cytochrome P450 1A1 (CYP1A1) T3801C polymorphism and breast cancer risk. However, the results remain inconclusive...
  41. Zhuo W, Zhang L, Zhu B, Qiu Z, Chen Z. Association between CYP1A1 Ile462Val variation and acute leukemia risk: meta-analyses including 2164 cases and 4160 controls. PLoS ONE. 2012;7:e46974 pubmed publisher
    Previously, CYP1A1 Ile462Val polymorphism has been indicated to be a risk factor for several malignancies...
  42. Ding G, Xu W, Liu H, Zhang M, Huang Q, Liao Z. CYP1A1 MspI polymorphism is associated with prostate cancer susceptibility: evidence from a meta-analysis. Mol Biol Rep. 2013;40:3483-91 pubmed publisher
    b>Cytochrome P450 1A1 (CYP1A1), an important phase I xenobiotic metabolizing enzyme, is responsible for metabolizing numerous carcinogens, particularly polycyclic aromatic hydrocarbons...
  43. Ahmad S, Arjumand W, Seth A, Nafees S, Rashid S, Ali N, et al. Risk of renal cell carcinoma and polymorphism in phase I xenobiotic metabolizing CYP1A1 and CYP2D6 enzymes. Urol Oncol. 2013;31:1350-7 pubmed publisher
    ..The possible association between RCC and a polymorphism of the CYP1A1 and CYP2D6 genes specific to the Indian population was examined using peripheral blood DNA from 196 RCC cases and ..
  44. Su M, Chen C, Kuo P, Hsu C, Lee I, Pan H, et al. Polymorphisms of estrogen-related genes jointly confer susceptibility to human spermatogenic defect. Fertil Steril. 2010;93:141-9 pubmed publisher
    ..genes (estrogen receptors [ER-alpha, ER-beta], estrogen synthesizing/metabolizing genes [CYP17, CYP19A1, HSD17B2, CYP1A1, CYP1B1, COMT], and transport genes [SHBG]) were genotyped...
  45. Lee K, Ward M, Han S, Ahn H, Kang H, Choi H, et al. Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk. Leuk Res. 2009;33:250-8 pubmed publisher
    ..between paternal smoking and childhood leukemia and to evaluate potential modification by polymorphisms in CYP1A1. Histologically confirmed childhood leukemia cases (n=164) and non-cancer controls (n=164) were recruited from ..
  46. Vorrink S, Severson P, Kulak M, Futscher B, Domann F. Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines. Toxicol Appl Pharmacol. 2014;274:408-16 pubmed publisher
    ..Exposure to 1% O2 prior to PCB 126 treatment significantly inhibited CYP1A1 mRNA and protein expression in human HepG2 and HaCaT cells...
  47. Peng M, Tsai Y, Chiang C, Huang Y, Chou M, Yeh K, et al. CYP1A1 protein activity is associated with allelic variation in pterygium tissues and cells. Mol Vis. 2012;18:1937-43 pubmed
    A thymine/cytosine point mutation in the MSP I restriction site of cytochrome P450 1A1 (CYP1A1) has been linked to susceptibility to smoking-related cancers and is reported to result in increased enzyme activity...
  48. Zhuo W, Zhang Y, Wang Y, Zhuo X, Zhu B, Cai L, et al. Association studies of CYP1A1 and GSTM1 polymorphisms with esophageal cancer risk: evidence-based meta-analyses. Arch Med Res. 2009;40:169-79 pubmed publisher
    Previous studies have implicated cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) polymorphisms as risk factors for various cancers...
  49. Zhuo W, Zhang L, Qiu Z, Zhu B, Chen Z. Does cytochrome P450 1A1 MspI polymorphism increase acute lymphoblastic leukemia risk? Evidence from 2013 cases and 2903 controls. Gene. 2012;510:14-21 pubmed publisher
    Previous studies indicated that cytochrome P450 1A1 (CYP1A1) MspI polymorphism might be a possible risk factor for several malignancies...
  50. Torresan C, Oliveira M, Torrezan G, de Oliveira S, Abuázar C, Losi Guembarovski R, et al. Genetic polymorphisms in oestrogen metabolic pathway and breast cancer: a positive association with combined CYP/GST genotypes. Clin Exp Med. 2008;8:65-71 pubmed publisher
    ..In this study we examine the role of the genes CYP1A1, CYP17, CYP2D6, GSTM1, GSTP1 and GSTT1 in breast cancer risk in Brazilian women...
  51. Yoshinari K, Yoda N, Toriyabe T, Yamazoe Y. Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5'-flanking region. Biochem Pharmacol. 2010;79:261-9 pubmed publisher
    Phenobarbital has long been known to increase cellular levels of CYP1A1 and CYP1A2 possibly through a pathway(s) independent of aryl hydrocarbon receptor...
  52. Varela Lema L, Taioli E, Ruano Ravina A, Barros Dios J, Anantharaman D, Benhamou S, et al. Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review. Genet Med. 2008;10:369-84 pubmed publisher
    The association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a meta-analysis of published case-control studies and a pooled analysis of both published and unpublished case-control studies from the ..
  53. Sergentanis T, Economopoulos K. Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis. Breast Cancer Res Treat. 2010;122:459-69 pubmed publisher
    Cytochrome P450s are enzymes which catalyze Phase-I metabolism reactions; cytochrome P450 1A1 (CYP1A1) is a member of the CYP1 family and participates in the metabolism of a vast number of xenobiotics, as well as endogenous substrates...
  54. Vani G, Mukesh N, Siva Prasad B, Rama Devi P, Hema Prasad M, Usha Rani P, et al. Association of CYP1A1*2A polymorphism with male infertility in Indian population. Clin Chim Acta. 2009;410:43-7 pubmed publisher
    The CYP1A1 gene is a polymorphic gene and encodes for the CYP1A1 enzyme that catalyzes the bioactivation of polycyclic aromatic hydrocarbons (PAHs)...
  55. Khvostova E, Pustylnyak V, Gulyaeva L. Genetic polymorphism of estrogen metabolizing enzymes in Siberian women with breast cancer. Genet Test Mol Biomarkers. 2012;16:167-73 pubmed publisher
    Allelic variants of cytochrome P450: CYP1A1, CYP1A2, CYP19 (aromatase), and the II-phase enzyme sulfotransferase 1A1 (SULT1A1) genes are associated with a high risk of hormone-dependent cancers...
  56. Cornelis M, Monda K, Yu K, Paynter N, Azzato E, Bennett S, et al. Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. PLoS Genet. 2011;7:e1002033 pubmed publisher
    ..4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2...
  57. Li W, Yue W, Zhang L, Zhao X, Ma L, Yang X, et al. Polymorphisms in GSTM1, CYP1A1, CYP2E1, and CYP2D6 are associated with susceptibility and chemotherapy response in non-small-cell lung cancer patients. Lung. 2012;190:91-8 pubmed publisher
    Studies of polymorphisms in CYP1A1, CYP2E1, CYP2D6, and GSTM1 and their relationship to lung cancer susceptibility and chemotherapy response have been reported, but the results are not consistent...
  58. Tekpli X, Zienolddiny S, Skaug V, Stangeland L, Haugen A, Mollerup S. DNA methylation of the CYP1A1 enhancer is associated with smoking-induced genetic alterations in human lung. Int J Cancer. 2012;131:1509-16 pubmed publisher
    b>CYP1A1 (cytochrome P4501A1) catalyze the conversion of polycyclic aromatic hydrocarbons into reactive metabolites, which may induce DNA damage...
  59. Chen J, Cheng M, Yi L, Jiang C. Relationship between CYP1A1 genetic polymorphisms and renal cancer in China. Asian Pac J Cancer Prev. 2011;12:2163-6 pubmed
    To study the potential role of cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms in the risk of renal cell cancer in Chinese...
  60. Zheng Y, Wang J, Sun L, Li H. Association between CYP1A1 polymorphism and colorectal cancer risk: a meta-analysis. Mol Biol Rep. 2012;39:3533-40 pubmed publisher
    ..Published data on the association between CYP1A1 (MspI and Ile ( 462 ) ..
  61. Salehi Z, Gholizadeh L, Vaziri H, Madani A. Analysis of GSTM1, GSTT1, and CYP1A1 in idiopathic male infertility. Reprod Sci. 2012;19:81-5 pubmed publisher
    ..a genetic association of the biotransformation enzymes and idiopathic male fertility, we studied GSTT1, GSTM1, and CYP1A1*2A polymorphisms in 150 infertile men and 200 healthy men as controls from Northern Iran...
  62. Reszka E, Czekaj P, Adamska J, Wasowicz W. Relevance of glutathione S-transferase M1 and cytochrome P450 1A1 genetic polymorphisms to the development of head and neck cancers. Clin Chem Lab Med. 2008;46:1090-6 pubmed publisher
    ..In the present study, we analyzed genetic polymorphisms of CYP1A1, GSTM1, GSTP1, and GSTT1 in 127 head and neck cancer patients and 151 hospital controls...
  63. Surekha D, Sailaja K, Rao D, Padma T, Raghunadharao D, Vishnupriya S. Association of CYP1A1*2 polymorphisms with breast cancer risk: a case control study. Indian J Med Sci. 2009;63:13-20 pubmed
    The Cytochrome P-4501A1 (CYP1A1) gene, located on chromosome 15q, is involved in the metabolism of carcinogens mainly polycyclic aromatic hydrocarbons as well as estrogen...
  64. Akgul S, Derman O, Alikasifoglu M, Aktas D. CYP1A1 polymorphism in adolescents with polycystic ovary syndrome. Int J Gynaecol Obstet. 2011;112:8-10 pubmed publisher
    To evaluate the rates of the CYP1A1 Ile/Val polymorphism in Turkish adolescent females...
  65. Guo R, Guo X. Quantitative assessment of the associations between CYP1A1 polymorphisms and gastric cancer risk. Tumour Biol. 2012;33:1125-32 pubmed publisher
    A great number of studies regarding the association between MspI and Ile462Val polymorphisms in the CYP1A1 gene and gastric cancer have been published. However, the results have been inconsistent...
  66. Shah P, Saurabh K, Pant M, Mathur N, Parmar D. Evidence for increased cytochrome P450 1A1 expression in blood lymphocytes of lung cancer patients. Mutat Res. 2009;670:74-8 pubmed publisher
    To develop blood lymphocyte cytochrome P450 1A1 (CYP1A1) expression as a surrogate for monitoring tissue expression for polycyclic aromatic hydrocarbon (PAH) induced toxicity, the present study attempted to characterize CYP1A1 mRNA ..
  67. Tung J, Wu H, Chiang C, Tsai Y, Chou M, Lee H, et al. An association between BPDE-like DNA adduct levels and CYP1A1 and GSTM1 polymorphisma in pterygium. Mol Vis. 2010;16:623-9 pubmed
    ..Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic ..
  68. Vijayakrishnan J, Houlston R. Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta-analysis. Haematologica. 2010;95:1405-14 pubmed publisher
    ..73, 95%ci:0.59-0.91), shmt1 c1420t (or=0.79, 95%ci: 0.65-0.98), rfc1 g80a (or=1.37, 95%ci: 1.11-1.69), cyp1a1*2a (or=1.36, 95%ci:1.11-1.66), cyp2e1*5b (or=1.99, 95%ci:1.32-3.00) nqo1 c609t (or=1.24, 95%ci:1.02-1...
  69. Imaizumi T, Higaki Y, Hara M, Sakamoto T, Horita M, Mizuta T, et al. Interaction between cytochrome P450 1A2 genetic polymorphism and cigarette smoking on the risk of hepatocellular carcinoma in a Japanese population. Carcinogenesis. 2009;30:1729-34 pubmed publisher
    ..275 hospital controls and 381 patients with chronic liver disease (CLD) without HCC], to investigate whether CYP1A1, CYP1A2, CYP2A6, CYP2E1, GSTM1 and NAT2 polymorphisms are related to the risk of HCC with any interaction with ..