Cyp1A1

Summary

Gene Symbol: Cyp1A1
Description: cytochrome P450 family 1 subfamily A member 1
Alias: AHH, AHRR, CP11, CYP1, CYPIA1, P1-450, P450-C, P450DX, aryl hydrocarbon hydroxylase, cytochrome P1-450, dioxin-inducible, cytochrome P450 form 6, cytochrome P450, family 1, subfamily A, polypeptide 1, cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1, cytochrome P450-C, cytochrome P450-P1, flavoprotein-linked monooxygenase, xenobiotic monooxygenase
Species: human

Top Publications

  1. ncbi A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer
    Christoph Sachse
    Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Carcinogenesis 23:1839-49. 2002
  2. doi Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis
    Theodoros N Sergentanis
    School of Medicine, National University of Athens, Athens, Greece
    Breast Cancer Res Treat 122:459-69. 2010
  3. doi Polymorphisms of CYP1A1 and GSTM1 and laryngeal cancer risk: evidence-based meta-analyses
    Wen lei Zhuo
    Institute of Cancer, Xinqiao Hospital, Third Military Medical University, 400038 Chongqing, China
    J Cancer Res Clin Oncol 135:1081-90. 2009
  4. doi Soy isoflavones, CYP1A1, CYP1B1, and COMT polymorphisms, and breast cancer: a case-control study in southwestern China
    Qiong Wang
    Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu, PR China
    DNA Cell Biol 30:585-95. 2011
  5. doi Impact of genetic variations of the CYP1A1, GSTT1, and GSTM1 genes on the risk of coronary artery disease
    Mehmet Taspinar
    Department of Medical Biology, Faculty of Medicine, Ankara University, Ankara, Turkey
    DNA Cell Biol 31:211-8. 2012
  6. ncbi Polymorphisms of the CYP1A1 and GSTM1 genes in relation to individual susceptibility to lung carcinoma in Chinese population
    S Chen
    Laboratory of Genetics, Jiangsu Institute for Cancer Research, 210009, Nanjing, PR China
    Mutat Res 458:41-7. 2001
  7. pmc Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002033. 2011
  8. ncbi Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers
    K Tsukasaki
    Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, 90024, USA
    Cancer Res 61:3770-4. 2001
  9. ncbi Genetic polymorphism of cytochrome P4501A1 and susceptibility to oral squamous cell carcinoma and oral precancer lesions associated with smoking/betel use
    Shou Yen Kao
    Department of Dentistry, Oral and Maxillofacial Surgery, Taipei Veterans General Hospital, Taiwan, ROC
    J Oral Pathol Med 31:505-11. 2002
  10. doi CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations
    Kyoung Mu Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 17:1120-6. 2008

Detail Information

Publications298 found, 100 shown here

  1. ncbi A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer
    Christoph Sachse
    Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Carcinogenesis 23:1839-49. 2002
    ..and 593 controls (433 matched case-control pairs) were genotyped for common polymorphisms in the cytochrome P450 (CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C9, CYP2C19 and CYP2D6), glutathione S-transferase (GSTM1, GSTP1 and GSTT1), ..
  2. doi Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis
    Theodoros N Sergentanis
    School of Medicine, National University of Athens, Athens, Greece
    Breast Cancer Res Treat 122:459-69. 2010
    Cytochrome P450s are enzymes which catalyze Phase-I metabolism reactions; cytochrome P450 1A1 (CYP1A1) is a member of the CYP1 family and participates in the metabolism of a vast number of xenobiotics, as well as endogenous substrates...
  3. doi Polymorphisms of CYP1A1 and GSTM1 and laryngeal cancer risk: evidence-based meta-analyses
    Wen lei Zhuo
    Institute of Cancer, Xinqiao Hospital, Third Military Medical University, 400038 Chongqing, China
    J Cancer Res Clin Oncol 135:1081-90. 2009
    Previous evidence implicates CYP1A1 and GSTM1 polymorphisms as risk factors for various cancers...
  4. doi Soy isoflavones, CYP1A1, CYP1B1, and COMT polymorphisms, and breast cancer: a case-control study in southwestern China
    Qiong Wang
    Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu, PR China
    DNA Cell Biol 30:585-95. 2011
    b>CYP1A1, CYP1B1, and COMT are key enzymes involved in estrogen metabolism. Soy isoflavones, phytoestrogens found in soy foods, may modify the activity of these enzymes...
  5. doi Impact of genetic variations of the CYP1A1, GSTT1, and GSTM1 genes on the risk of coronary artery disease
    Mehmet Taspinar
    Department of Medical Biology, Faculty of Medicine, Ankara University, Ankara, Turkey
    DNA Cell Biol 31:211-8. 2012
    ..In this study we investigated the effects of genetic polymorphisms of the CYP1A1*2C, GSTT1, and GSTM1 enzymes on CAD risk in a Turkish population...
  6. ncbi Polymorphisms of the CYP1A1 and GSTM1 genes in relation to individual susceptibility to lung carcinoma in Chinese population
    S Chen
    Laboratory of Genetics, Jiangsu Institute for Cancer Research, 210009, Nanjing, PR China
    Mutat Res 458:41-7. 2001
    Cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) metabolize tobacco-related carcinogens...
  7. pmc Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002033. 2011
    ..4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2...
  8. ncbi Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers
    K Tsukasaki
    Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, 90024, USA
    Cancer Res 61:3770-4. 2001
    ..to ATL and several polymorphisms: the three "decreased-detoxifying" polymorphisms in GSTM1, GSTT1, and CYP1A1, the "proapoptotic" polymorphism in BCL2, and the five "high-production" polymorphisms in tumor necrosis factor ..
  9. ncbi Genetic polymorphism of cytochrome P4501A1 and susceptibility to oral squamous cell carcinoma and oral precancer lesions associated with smoking/betel use
    Shou Yen Kao
    Department of Dentistry, Oral and Maxillofacial Surgery, Taipei Veterans General Hospital, Taiwan, ROC
    J Oral Pathol Med 31:505-11. 2002
    The importance of the CYP1A1 polymorphisms at exon 7 (Ile/Val) and 3'-untranslated region (3'-UTR) has been controversial in oral squamous cell carcinoma (OSCC) or head and neck SCC (HNSCC) denoting the value of exploring the correlation ..
  10. doi CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations
    Kyoung Mu Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 17:1120-6. 2008
    To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] and deletion of GSTM1 and GSTT1 in lung cancer development in Asian populations, a pooled analysis was conducted on 13 existing studies included in Genetic ..
  11. pmc Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on GxE interactions and pathogenic pathways
    Hui Ju Tsai
    Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Hum Genet 123:359-69. 2008
    ..Previously, we reported that maternal smoking and metabolic gene polymorphisms of CYP1A1 MspI and GSTT1 synergistically increase the risk of low birth weight...
  12. doi Risk of renal cell carcinoma and polymorphism in phase I xenobiotic metabolizing CYP1A1 and CYP2D6 enzymes
    Shiekh Tanveer Ahmad
    Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard Hamdard University, New Delhi, India
    Urol Oncol 31:1350-7. 2013
    ..The possible association between RCC and a polymorphism of the CYP1A1 and CYP2D6 genes specific to the Indian population was examined using peripheral blood DNA from 196 RCC cases and ..
  13. doi Functional CYP1A1 genetic variants, alone and in combination with smoking, contribute to development of head and neck cancers
    Li Liu
    State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China
    Eur J Cancer 49:2143-51. 2013
    b>CYP1A1 plays an essential role in pathogenesis of head and neck cancers. Functional CYP1A1 Ile462Val and MspI single nucleotide polymorphisms (SNP) are considered to have significant effects on risk of head and neck cancers...
  14. doi CYP1A1 Ile462Val polymorphism and cervical cancer: evidence from a meta-analysis
    ShuYan Yang
    Department of Gynecology and Obstetrics, Fourth Affiliated Hospital, Harbin Medical University, Harbin 150001, China
    Tumour Biol 33:2265-72. 2012
    Many publications have evaluated the correlation between Cytochrome P450 1A1 (CYP1A1) Ile462Val polymorphism and cervical cancer risk, but the results remain inconclusive...
  15. pmc CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lung squamous carcinoma and smokers: a meta-analysis
    Ya Nan Ji
    Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, China
    PLoS ONE 7:e43397. 2012
    Many studies have examined the association between the CYP1A1 Ile462Val gene polymorphisms and lung cancer risk in various populations, but their results have been inconsistent...
  16. ncbi Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and ovarian cancer risk: a meta-analysis
    Theodoros N Sergentanis
    School of Medicine, University of Athens, Athens, Greece
    Mol Biol Rep 39:9921-30. 2012
    ..to examine whether the genotype status of MspI, Ile462Val, and Thr461Asn polymorphisms in Cytochrome P450 1A1 (CYP1A1) is associated with ovarian cancer risk...
  17. doi Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and cervical cancer risk: a meta-analysis
    Theodoros N Sergentanis
    School of Medicine, University of Athens, Athens, Greece
    Mol Biol Rep 39:6647-54. 2012
    ..aims to examine whether the genotype status of MspI and Ile462Val polymorphisms in Cytochrome-P450 1A1 (CYP1A1) is associated with cervical cancer risk...
  18. ncbi CYP1A1 and GSTM1 polymorphisms in relation to lung cancer risk in Chinese women
    Xiaohong R Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, Bethesda MD 20892, USA
    Cancer Lett 214:197-204. 2004
    We examined CYP1A1 (I462V) and GSTM1 null polymorphisms in 200 female cases and 144 female controls selected from a population-based case-control study of lung cancer conducted in northeast China, where the rates of lung cancer among ..
  19. pmc Association between CYP1A1 Ile462Val variation and acute leukemia risk: meta-analyses including 2164 cases and 4160 controls
    Wenlei Zhuo
    Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    PLoS ONE 7:e46974. 2012
    Previously, CYP1A1 Ile462Val polymorphism has been indicated to be a risk factor for several malignancies...
  20. doi Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated meta-analysis including 1,515 cases and 2,233 controls
    Xianlu Zhuo
    Department of Stomatology, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    Tumour Biol 33:2079-89. 2012
    ..containing data from prior to Jan 2008 regarding this issue failed to find a significant association between CYP1A1 Ile462Val variation and oral cancer susceptibility...
  21. pmc Genetic polymorphisms in CYP1A1, CYP1B1 and COMT genes in Greenlandic Inuit and Europeans
    Mandana Ghisari
    Centre for Arctic Health and Unit of Cellular and Molecular Toxicology, Department of Public Health, Aarhus University, Denmark
    Int J Circumpolar Health 72:21113. 2013
    ....
  22. pmc CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: a meta-analysis
    Jian Qiang Jin
    Department of Pathology, Affiliated No 4 Hospital of Soochow University, Wuxi 214062, Jiangsu Province, China
    World J Gastroenterol 17:260-6. 2011
    To study the relation between CYP1A1 Ile462Val polymorphism and colorectal cancer risk by meta-analysis.
  23. doi Interactions between CYP1A1 polymorphisms and cigarette smoking are associated with the risk of hepatocellular carcinoma: evidence from epidemiological studies
    Lei Yu
    Department of Infectious Disease, the Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China
    Mol Biol Rep 39:6641-6. 2012
    The Cytochrome P-450 1A1 (CYP1A1) gene has been implicated in the etiology of hepatocellular carcinoma (HCC). However, the results have been inconsistent...
  24. ncbi CYP1A1 polymorphism and risk of gynecological malignancy in Japan
    T Sugawara
    Departments of Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Int J Gynecol Cancer 13:785-90. 2003
    ..Estrogens are metabolized by cytochrome P450 1A1 (CYP1A1) and converted into catecholestrogens, which are carcinogens...
  25. doi Association of CYP1A1*2A polymorphism with male infertility in Indian population
    Gudimella Tirumala Vani
    Institute of Genetics and Hospital for Genetics Diseases, Osmania University, Begumpet, Hyderabad 500016, Andhra Pradesh, India
    Clin Chim Acta 410:43-7. 2009
    The CYP1A1 gene is a polymorphic gene and encodes for the CYP1A1 enzyme that catalyzes the bioactivation of polycyclic aromatic hydrocarbons (PAHs)...
  26. doi Investigations of the posttranslational mechanism of arsenite-mediated downregulation of human cytochrome P4501A1 levels: the role of heme oxygenase-1
    Erin E Bessette
    Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, Albany, NY 12201 0509, USA
    J Biochem Mol Toxicol 23:222-32. 2009
    ..cocontaminant of polycyclic aromatic hydrocarbons (PAHs), diminishes the PAH-mediated upregulation of human CYP1A1, the enzyme that bioactivates PAHs to carcinogenic metabolites...
  27. pmc Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Hum Mol Genet 20:2071-7. 2011
    ..two sequence variants significantly associated with increased coffee consumption: rs2472297-T located between CYP1A1 and CYP1A2 at 15q24 (P = 5.4 · 10(-14)) and rs6968865-T near aryl hydrocarbon receptor (AHR) at 7p21 (P = 2...
  28. ncbi GSTM1, GSTT1 and CYP1A1 detoxification gene polymorphisms and susceptibility to smoking-related coronary artery disease: a case-only study
    Samantha Manfredi
    CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Massa, Italy
    Mutat Res 621:106-12. 2007
    ..of this study was to test the hypothesis that the inheritance of polymorphic genes encoding cytochrome P450 1A1 (CYP1A1 MspI) and glutathione S-transferases (GSTM1(null) and GSTT1(null)) may be causally associated with the presence ..
  29. ncbi Relationship between genetic polymorphisms of drug-metabolizing enzymes (CYP1A1, CYP2E1, GSTM1, and NAT2), drinking habits, histological subtypes, and p53 gene point mutations in Japanese patients with gastric cancer
    Shioto Suzuki
    Department of Molecular and Cellular Pathology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    J Gastroenterol 39:220-30. 2004
    ..Therefore, we studied the relationship between the genetic polymorphisms of drug-metabolizing enzymes, drinking habits, histological subtypes, and p53 gene point mutations in Japanese patients with gastric cancer...
  30. doi A case-control study of CYP1A1, GSTT1 and GSTM1 gene polymorphisms, pregnancy smoking and fetal growth restriction
    Ali Delpisheh
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, UK
    Eur J Obstet Gynecol Reprod Biol 143:38-42. 2009
    To determine the role of maternal CYP1A1, GSTT1, and GSTM1 metabolic gene polymorphisms in modulating the association between pregnancy smoking exposure and fetal growth restriction.
  31. doi Meta-analysis of cytochrome P4501A1 MspI gene polymorphism and childhood acute leukemia
    Yao Dong Zhang
    Department of Endocrinology, Zhengzhou Children s Hospital, Zhengzhou 450053, Henan, China
    Biomed Environ Sci 24:683-7. 2011
    To investigate the relationship between cytochrome P4501A1 (CYP1A1) Msp I gene polymorphism and childhood acute leukemia (AL).
  32. ncbi CYP1A1 polymorphisms modify overall survival in acute myeloid leukemia patients
    Luis Arthur Flores Pelloso
    Leuk Lymphoma 48:1211-5. 2007
  33. doi Association of cytochrome P450, glutathione S-transferase and N-acetyl transferase 2 gene polymorphisms with incidence of acute myeloid leukemia
    Sunipa Majumdar
    Department of Biophysics, Molecular Biology and Genetics, University of Calcutta, India
    Eur J Cancer Prev 17:125-32. 2008
    ....
  34. doi Association studies of CYP1A1 and GSTM1 polymorphisms with esophageal cancer risk: evidence-based meta-analyses
    Wen lei Zhuo
    Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    Arch Med Res 40:169-79. 2009
    Previous studies have implicated cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) polymorphisms as risk factors for various cancers...
  35. ncbi Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women
    Aesun Shin
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110 799, Korea
    Exp Mol Med 39:361-6. 2007
    Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma...
  36. doi Association between CYP1A1 polymorphism and colorectal cancer risk: a meta-analysis
    Yuan Zheng
    Department of Center for Disease Control and Prevention of Shaanxi Province, 3Jiandong Road, 710054, Shaanxi, Xi an, People s Republic of China
    Mol Biol Rep 39:3533-40. 2012
    ..Published data on the association between CYP1A1 (MspI and Ile ( 462 ) ..
  37. pmc Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women
    Michele L Cote
    Population Studies and Prevention Program, Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI 48201, USA
    Carcinogenesis 30:626-35. 2009
    ..Eleven SNPs in 10 different genes were examined in relation to risk: CYP1A1 Msp1, CYP1A1 Ile462Val, CYP1B1 Leu432Val, CYP17, CYP19A1, XRCC1 Gln399Arg, COMT Val158Met, NQO1 Pro187Ser, GSTM1, ..
  38. ncbi Combined effects of genetic polymorphisms in six selected genes on lung cancer susceptibility
    Mihi Yang
    Department of Toxicology, College of Pharmacy, Sookmyung Women s University, 53 12 Chungpa Dong, Yongsan gu, Seoul 140 742, Republic of Korea
    Lung Cancer 57:135-42. 2007
    ..As results, genetic polymorphisms in the GSTP1, MPO, and CYP1A1 among the genetic factors showed associations with lung cancer risk...
  39. ncbi Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review
    L F Masson
    Epidemiology Group, Department of Public Health, University of Aberdeen, Aberdeen, Scotland
    Am J Epidemiol 161:901-15. 2005
    ..It is expressed predominantly in extrahepatic tissues, including the breast. Four CYP1A1 gene polymorphisms (3801T --> C, Ile462Val, 3205T --> C, and Thr461Asp) have been studied in relation to ..
  40. ncbi Glutathione S-transferase genotypes and allergic responses to diisocyanate exposure
    P Piirilä
    Departments of Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland
    Pharmacogenetics 11:437-45. 2001
    ..0, 95% CI 2.19-55.3). The results suggest, for the first time, that the polymorphic GSTs, especially the mu class GSTs, play an important role in inception of ill effects related to occupational exposure to diisocyanates...
  41. ncbi Polymorphism in CYP1A1 and CYP2E1 genes and susceptibility to leukoplakia in Indian tobacco users
    Nilabja Sikdar
    Anthropology and Human Genetics Unit, Biological Sciences Division, Indian Statistical Institute, 203 B T Road, Kolkata 700108, India
    Cancer Lett 195:33-42. 2003
    ..In this study, we investigated polymorphisms at two sites in the CYP1A1 and three sites in the CYP2E1 genes in 99 leukoplakia patients and 227 controls from one Indian population...
  42. ncbi Polymorphisms of CYP1A1 and glutathione S-transferase and susceptibility to adult acute myeloid leukemia
    Francesco D'Alo
    Istituto di Ematologia, Universita Cattolica S Cuore, Rome, Italy
    Haematologica 89:664-70. 2004
    ..We studied the polymorphisms of cytochrome P450 CYP1A1 and glutathione S-transferase (GST), enzymes involved in the metabolism of carcinogens and anti-cancer drugs, as ..
  43. ncbi CYP1B1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women
    Kyong Ah Yoon
    Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, South Korea
    Lung Cancer 60:40-6. 2008
    ..Here, we investigated the association of CYP1A1 Ile462Val, CYP1B1 Leu432Val, GSTP1 Ile105Val, MPO G-463A polymorphisms and lung cancer risk in never-smoking ..
  44. ncbi CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people
    L Quinones
    Faculty of Medicine, Laboratory of Environmental Toxicology and School of Public Health, University of Chile, Santiago, Chile
    Cancer Lett 174:35-44. 2001
    b>CYP1A1, CYP2E1 and GSTM1 polymorphisms were evaluated in Chilean healthy controls and lung cancer patients...
  45. pmc Combinations of cytochrome P-450 genotypes and risk of early-onset lung cancer in Caucasians and African Americans: a population-based study
    M L Cote
    Population Studies and Prevention Program, Karmanos Cancer Institute at Wayne State University School of Medicine, Detroit, MI, United States
    Lung Cancer 55:255-62. 2007
    Polymorphisms in CYP1A1 and CYP1B1 genes in humans are associated with reduction of enzymatic activity towards several substrates, including those found in tobacco smoke...
  46. ncbi Studies on CYP1A1, CYP1B1 and CYP3A4 gene polymorphisms in breast cancer patients
    Marta Ociepa-Zawal
    Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poland
    Ginekol Pol 80:819-23. 2009
    The role of CYP1A1, CYP1B1 and CYP3A4 polymorphism in pathogenesis of breast cancer has not been fully elucidated...
  47. pmc Interaction between maternal passive smoking during pregnancy and CYP1A1 and GSTs polymorphisms on spontaneous preterm delivery
    Yi juan Luo
    Department of Biostatistics and Epidemiology, School of Public Health, Sun Yat Sen University, Guangzhou, Guangdong, China
    PLoS ONE 7:e49155. 2012
    ..maternal passive smoking during pregnancy and the risk of spontaneous PTD and to explore the potential interaction of the single or joint gene polymorphism of CYP1A1 and GSTs with maternal passive smoking on the risk of spontaneous PTD.
  48. ncbi Cytochrome P450 1A1, 2E1 and GSTM1 gene polymorphisms and susceptibility to colorectal cancer in the Saudi population
    Hesham Mahmoud Saeed
    Department of Biochemistry, College of Science, King Saud University, Riyadh, KSA
    Asian Pac J Cancer Prev 14:3761-8. 2013
    ..The aim of the present study was to investigate contributions of CYP1A1, CYP2E1, and GSTM1 gene polymorphisms.
  49. doi Quantitative assessment of the associations between CYP1A1 polymorphisms and gastric cancer risk
    Renyong Guo
    Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
    Tumour Biol 33:1125-32. 2012
    A great number of studies regarding the association between MspI and Ile462Val polymorphisms in the CYP1A1 gene and gastric cancer have been published. However, the results have been inconsistent...
  50. doi CYP1A1 MspI polymorphism is associated with prostate cancer susceptibility: evidence from a meta-analysis
    Gang Ding
    Department of Oncology, Chongming Branch of Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 202150, China
    Mol Biol Rep 40:3483-91. 2013
    Cytochrome P450 1A1 (CYP1A1), an important phase I xenobiotic metabolizing enzyme, is responsible for metabolizing numerous carcinogens, particularly polycyclic aromatic hydrocarbons...
  51. ncbi Relationship between CYP1A1 genetic polymorphisms and renal cancer in China
    Junxiang Chen
    Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, China
    Asian Pac J Cancer Prev 12:2163-6. 2011
    To study the potential role of cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms in the risk of renal cell cancer in Chinese.
  52. doi CYP1A1 gene polymorphisms and smoking status as modifier factors for lung cancer risk
    Atef G Hussein
    Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
    Gene 541:26-30. 2014
    ..The aim of this work was to identify the correlation between CYP1A1 m1 and m2 polymorphisms and lung cancer risk and figure its interactions with smoking as genetic modifiers in the ..
  53. doi Relevance of glutathione S-transferase M1 and cytochrome P450 1A1 genetic polymorphisms to the development of head and neck cancers
    Edyta Reszka
    Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland
    Clin Chem Lab Med 46:1090-6. 2008
    ..Cytochrome P450 (CYP) and glutathione S-transferase (GST) gene variants have been intensively investigated for their implication in the development of different neoplasms...
  54. ncbi The risk of developing cervical cancer in Mexican women is associated to CYP1A1 MspI polymorphism
    Teresa Juarez-Cedillo
    Epidemiological Research and Health Services Unit, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico
    Eur J Cancer 43:1590-5. 2007
    The aim of the study was to evaluate the association of two CYP1A1 polymorphisms (Msp1 and exon 7) with cervical cancer in Mexican women considering their smoking habit...
  55. ncbi [Analysis of the polymorphic alleles of genes encoding phase 1 and phase 2 detoxication enzymes in patients with endometriosis]
    T E Ivashchenko
    Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St Petersburg, 199034 Russia
    Genetika 39:525-9. 2003
    Polymorphysms of the three genes encoding phase 1 (CYP1A1, mEPH1, and CYP2E2) and the three genes encoding phase 2 (NAT2, GSTM1, and GSTT1) xenobiotic detoxication enzymes were typed by use of PCR in 74 patients with extragenital ..
  56. doi Association of GSTT1, GSTM1 and CYP1A1 polymorphisms with susceptibility to systemic lupus erythematosus in the Chinese population
    Jufeng Zhang
    Biomedical Research Institute, Shenzhen PKU HKUST Medical Center, Shenzhen, 518036, China
    Clin Chim Acta 411:878-81. 2010
    GSTT1, GSTM1, CYP1A1 are enzymes responsible for the detoxification of the toxicant which may be involved in the development of systemic lupus erythematosus (SLE)...
  57. ncbi Polychlorinated biphenyls, cytochrome P450 1A1, and breast cancer risk in the Nurses' Health Study
    Francine Laden
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1560-5. 2002
    ..be partially determined by polymorphisms in the gene encoding the biotransformation enzyme cytochrome P450 1A1 (CYP1A1)...
  58. doi Association of CYP1A1 and glutathione S-transferase polymorphisms with male factor infertility
    Sena Erdogan Aydos
    Department of Medical Biology, Faculty of Medicine, Ankara University, Ankara, Turkey
    Fertil Steril 92:541-7. 2009
    To examine whether a relationship exists between genetic polymorphisms of glutathione S-transferase (GST) M1 and T1, CYP1A1(*)2C, and male factor infertility.
  59. doi CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer
    Guy Gutman
    Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Gynecol Cancer 19:1300-2. 2009
    To assess the frequency distribution of the CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer.
  60. doi Evidence for increased cytochrome P450 1A1 expression in blood lymphocytes of lung cancer patients
    Parag P Shah
    Developmental Toxicology Division, Indian Institute of Toxicology Research IITR, CSIR, MG Marg, Lucknow, UP, India
    Mutat Res 670:74-8. 2009
    To develop blood lymphocyte cytochrome P450 1A1 (CYP1A1) expression as a surrogate for monitoring tissue expression for polycyclic aromatic hydrocarbon (PAH) induced toxicity, the present study attempted to characterize CYP1A1 mRNA ..
  61. ncbi Genetic polymorphism of the CYP1A1, CYP2E1, GSTM1 and GSTT1 genes and lung cancer susceptibility in a north indian population
    R C Sobti
    Department of Biotechnology, Punjab University, Chandigarh, India
    Mol Cell Biochem 266:1-9. 2004
    b>CYP1A1, CYP2E1, GSTM1 and GSTT1 polymorphisms were evaluated in north Indian lung cancer patients and controls. The estimated relative risk for lung cancer associated with the CYP1A1*2C allele was 2.68...
  62. ncbi Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis
    Yuet Kin Leung
    Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    Cancer Res 65:3726-34. 2005
    ..In this study, we showed overexpression of CYP1A1 mRNA, but not CYP1B1 transcripts, in ovarian cancer cell lines when compared with primary cultures or immortalized ..
  63. doi Polymorphisms of estrogen-related genes jointly confer susceptibility to human spermatogenic defect
    Mei Tsz Su
    Departments of Obstetrics and Gynecology, National Cheng Kung University College of Medicine, Tainan City, Taiwan, Republic of China
    Fertil Steril 93:141-9. 2010
    ..To establish a multilocus model for studying the effect of estrogen-related genes on impaired spermatogenesis...
  64. doi Lung cancer risk in north Indian population: role of genetic polymorphisms and smoking
    Munish Kumar
    Petroleum Toxicology Division, Indian Institute of Toxicology Research, M G Marg, P O Box No 80, Lucknow, 226001, India
    Mol Cell Biochem 322:73-9. 2009
    ..The polymorphic genes explored were CYP1A1, GSTM1, GSTP1 and GSTT1 using techniques of Polymerase chain reaction (PCR), Restriction Fragment Length ..
  65. pmc Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women
    Yu Li
    Department of Epidemiology, School of Public Heath and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Breast Cancer Res 6:R460-73. 2004
    Previous epidemiologic studies suggest that women with variant cytochrome P4501A1 (CYP1A1) genotypes who smoke cigarettes are at increased risk for breast cancer.
  66. ncbi Association of CYP1A1 polymorphisms with breast cancer in North Indian women
    Neetu Singh
    Genotoxicity Laboratory, Toxicology Division, Central Drug Research Institute, Lucknow 226 001, Uttar Pradesh, India
    Oncol Res 16:587-97. 2007
    ..In the present case control study four CYP1A1 gene polymorphisms, m1 (T6235C), m2 (A4889G), m3 (T5639C), and m4 (C4887A) were studied for their association with ..
  67. doi Association of CYP1A1 Msp1 polymorphism with tobacco-related risk of gallbladder cancer in a north Indian population
    Sachchida Nand Pandey
    Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Eur J Cancer Prev 17:77-81. 2008
    Polymorphisms in the gene encoding the metabolic enzyme cytochrome P450 1A1 (CYP1A1) might contribute to the variability in individual susceptibility to gallbladder cancer (GBC)...
  68. ncbi Polymorphisms in CYP1A1 gene are associated with male infertility in a Chinese population
    Ningxia Lu
    Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China
    Int J Androl 31:527-33. 2008
    Cytochrome P4501A1 (CYP1A1) is a key enzyme in phase I bioactivation of polycyclic aromatic hydrocarbons (PAHs), which have potential reproductive toxicity...
  69. doi Polymorphisms of cytochrome P450 1A1, cigarette smoking and risk of coronary artery disease
    Chih Ching Yeh
    Department of Health Risk Management, China Medical University College of Public Health, Taichung 404, Taiwan
    Mutat Res 667:77-81. 2009
    ..Cytochrome P450 1A1 (CYP1A1) is a key enzyme that metabolizes the cigarette toxin relevant to smoking-induced atherogenesis...
  70. ncbi The effect of CYP1A1 and GSTM1 gene polymorphisms in bladder cancer development in a Turkish population
    Tulin Ozturk
    Department of Pathology, Faculty of Cerrahpasa Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
    In Vivo 25:663-8. 2011
    The aim of this study was to investigate a possible association of the CYP1A1 Ile462Val and GSTM1 null polymorphisms with the risk of developing bladder cancer in a Turkish population.
  71. ncbi CYP1A1, GSTM1, and GSTP1 genetic polymorphisms and urinary 1-hydroxypyrene excretion in non-occupationally exposed individuals
    P V Nerurkar
    Cancer Research Center of Hawaii, Etiology Program, University of Hawaii, Honolulu 96813, USA
    Cancer Epidemiol Biomarkers Prev 9:1119-22. 2000
    The CYP1A1 and glutathione S-transferase enzymes (e.g., GSTM1 and GSTP1) are involved in the activation and conjugation of polycyclic aromatic hydrocarbons (PAHs), respectively, and are controlled by genes that are polymorphic...
  72. doi Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder
    Mark Sutherland
    Institute of Cancer Therapeutics, University of Bradford, Bradford, UK
    Mol Cancer Ther 12:27-37. 2013
    We identify cytochrome P450 1A1 (CYP1A1) as a target for tumor-selective drug development in bladder cancer and describe the characterization of ICT2700, designed to be metabolized from a prodrug to a potent cytotoxin selectively by ..
  73. ncbi Effect of CYP1A1 MspI polymorphism on cigarette smoking related coronary artery disease and diabetes
    Xing Li Wang
    Cardiovascular Genetics Laboratory, Eastern Heart Clinic, Center of Thrombosis and Vascular Research, University of New South Wales, Sydney, Australia
    Atherosclerosis 162:391-7. 2002
    b>CYP1A1, is one of the key detoxifying enzymes catabolizing cigarette smoking derived toxins and may be relevant to smoking-induced atherogenesis...
  74. doi Analysis of GSTM1, GSTT1, and CYP1A1 in idiopathic male infertility
    Zivar Salehi
    Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran
    Reprod Sci 19:81-5. 2012
    ..a genetic association of the biotransformation enzymes and idiopathic male fertility, we studied GSTT1, GSTM1, and CYP1A1*2A polymorphisms in 150 infertile men and 200 healthy men as controls from Northern Iran...
  75. doi CYP1A1 polymorphism in adolescents with polycystic ovary syndrome
    Sinem Akgul
    Department of Pediatrics, Division of Adolescent Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Int J Gynaecol Obstet 112:8-10. 2011
    To evaluate the rates of the CYP1A1 Ile/Val polymorphism in Turkish adolescent females.
  76. doi Quantitative synthesis of the association between the cytochrome P450 1A1 Ile462Val polymorphism and prostate cancer risk
    Guangye Han
    Urology Department, The First Affiliated Hospital of Xinxiang Medical University, Healthy Road No 88, Weihui, Henan, 453100, China
    Tumour Biol 34:1511-6. 2013
    The association between the cytochrome P450 1A1 (CYP1A1) Ile462Val polymorphism and prostate cancer risk remains inconclusive owing to the conflicting findings from previous studies...
  77. doi Smoking status modifies the relation between CYP1A1*2C gene polymorphism and idiopathic male infertility: the importance of gene-environment interaction analysis for genetic studies of the disease
    Sergey L Yarosh
    1Family Planning and Reproductive Health Clinic, Regional Perinatal Center, Kursk, Russian Federation
    Reprod Sci 20:1302-7. 2013
    ..was designed to investigate the associations of polymorphisms Ile462Val and 3801T>C of the cytochrome P450 1A1 (CYP1A1) gene with idiopathic male infertility (IMI) and to assess the impact of smoking status on the relationship ..
  78. ncbi Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia
    Maja Krajinovic
    Service d hématologie oncologie, Centre de Recherche, Hopital Sainte Justine, Montreal, Quebec, H3T 1C5 Canada
    Clin Cancer Res 8:802-10. 2002
    ..Similarly, differential capacity of ALL patients to process carcinogens and chemotherapeutic drugs could both modify an individual's risk of recurrent malignancy and response to therapy...
  79. doi Association of CYP1A1 gene polymorphism with chronic kidney disease: a case control study
    Manushi Siddarth
    Environmental Biochemistry and Immunology Laboratory, Department of Biochemistry, University College of Medical Sciences University of Delhi and G T B Hospital, Delhi 110095, India
    Environ Toxicol Pharmacol 36:164-70. 2013
    b>CYP1A1 is an important xenobiotic metabolizing enzyme, present in liver and kidney. Expression of CYP1A1 enzyme increases manifold when kidney cells are exposed to nephrotoxins/chemicals leading to oxidative stress-induced cell damage...
  80. ncbi Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae
    H P Eugster
    Institute of Toxicology, Swiss Federal Institute of Technology, Schwerzenbach
    Drug Metab Dispos 21:43-9. 1993
    ..Two cDNAs of human CYP1A1 and CYP1A2 were expressed in yeast Saccharomyces cerevisiae, and microsomes of transformed strains contained ..
  81. doi Does cytochrome P450 1A1 MspI polymorphism increase acute lymphoblastic leukemia risk? Evidence from 2013 cases and 2903 controls
    Wenlei Zhuo
    Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    Gene 510:14-21. 2012
    Previous studies indicated that cytochrome P450 1A1 (CYP1A1) MspI polymorphism might be a possible risk factor for several malignancies...
  82. ncbi CYP 1A1 polymorphism and risk of lung cancer in relation to tobacco smoking: a case-control study in China
    N Song
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Carcinogenesis 22:11-6. 2001
    The impact of genetic polymorphisms in CYP1A1 on susceptibility to lung cancer has received particular interest in recent years since this enzyme plays a central role in activation of major classes of tobacco carcinogens...
  83. ncbi CYP1A1 variants and smoking-related lung cancer in San Francisco Bay area Latinos and African Americans
    Margaret R Wrensch
    Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, USA
    Int J Cancer 113:141-7. 2005
    We examined CYP1A1 T6235C (M1) and A4889G (M2) polymorphisms in San Francisco Bay Area African Americans and Latinos who were newly diagnosed with primary lung cancer from September 1998 to November 2002 and in age-gender-ethnicity ..
  84. ncbi Cytochrome P450 1A1 polymorphism and childhood leukemia: an analysis of matched pairs case-control genotype data
    Steve Selvin
    School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA
    Cancer Epidemiol Biomarkers Prev 13:1371-4. 2004
    ....
  85. ncbi Influence of antioxidants and the CYP1A1 isoleucine to valine polymorphism on the smoking--lung cancer association
    D Ratnasinghe
    Division of Clinical Sciences, National Cancer Institute, NIH, Bethseda, MD, USA
    Anticancer Res 21:1295-9. 2001
    To evaluate the association between CYP1A1 genotype and lung cancer risk and to assess the effect of CYP1A1 genotype and antioxidant supplementation on the smoking--lung cancer relationship we conducted a case-control study nested within ..
  86. ncbi Influence of genetic polymorphisms of CYP1A1 and GSTM1 on the urinary levels of 1-hydroxypyrene
    P Apostoli
    Chair of Industrial Hygiene, Department of Experimental and Applied Medicine, University of Brescia, P le Spedali Civili, 1, Brescia 25123, Italy
    Toxicol Lett 144:27-34. 2003
    ..of the genetic polymorphism of two enzymes involved in the biotransformation of xenobiotics, cytochrome P450 1A1 (CYP1A1) and glutathione-S-transferase M1 (GSTM1), on the urinary levels of 1-hydroxypyrene (1-OH-P) in workers exposed to ..
  87. ncbi CYP1A1 m1 and m2 polymorphisms: genetic susceptibility to lung cancer
    Paula Mota
    Instituto de Genetica, Faculdade de Medicina, 3000 Coimbra
    Rev Port Pneumol 16:89-98. 2010
    ..The CYP1A1 gene codifies the phase I enzyme aryl hydrocarbon hydroxilase (AHH) belonging to the cytochrome P450 system that ..
  88. ncbi Role of DNA mismatch repair genetic polymorphisms in the risk of childhood acute lymphoblastic leukaemia
    Geraldine Mathonnet
    Service d hématologie oncologie, Centre de cancérologie Charles Bruneau, Centre de Recherche, Hopital Sainte Justine, and Département de Pédiatrie, Universite de Montreal, Montreal, Quebec, Canada
    Br J Haematol 123:45-8. 2003
    ..influence ALL susceptibility, we found that the MLH1 variant Val-219 further increases the risk of GSTM1 null and CYP1A1*2A genotypes [combined odds ratio (OR) = 6.0, P = 0.002] as well as that of CYP2E1*5 (OR = 15.8, P = 0.001)...
  89. pmc CYP1A1 gene polymorphisms as a risk factor for pterygium
    Chi Hsien Young
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Mol Vis 16:1054-8. 2010
    Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs)...
  90. ncbi The GST deletions and NQO1*2 polymorphism confers interindividual variability of response to treatment in patients with acute myeloid leukemia
    Eva Barragan
    Molecular Biology Laboratory, Dpt Medical Pathology, Spain
    Leuk Res 31:947-53. 2007
    ..patients diagnosed with de novo acute myeloid leukemia (AML) to clarify the influence of the genetic polymorphisms CYP1A1*2A, CYP3A4*1B, CYP2E1*5B, del{GSTT1}, del{GSTM1}, and NQO1*2 on disease outcome...
  91. pmc Relationship of tobacco smoking CYP1A1 GSTM1 gene polymorphism and esophageal cancer in Xi'an
    An hui Wang
    Department of Epidemiology, Faculty of Preventive Medicine, Fourth Military Medical University Xi an 710032, Shaanxi Province, China
    World J Gastroenterol 8:49-53. 2002
    To analyze the association of tobacco smoking polymorphism of CYP1A1 (7th exon) and GSTM1 genotype and esophageal cancer(EC) in Xi'an.
  92. doi Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility
    Han Chun Chen
    Department of Biochemistry, School of Biological Science and Technology, Central South University, Changsha, Hunan, China
    Eur J Cancer Prev 17:251-8. 2008
    The genetic polymorphisms of biotransformation phase I enzymes, cytochrome P450 (CYP1A1 and CYP2D6), and phase II enzymes, glutathione S-transferase (GSTM1 and GSTT1), were analyzed in 204 healthy persons and 348 leukemia patients, who ..
  93. ncbi Cytochrome P4501A1 polymorphism is associated with susceptibility to acute lymphoblastic leukemia in adult Mexican patients
    M P Gallegos-Arreola
    Division de Medicina Molecular, Centro de Investigacion Biomedica de Occidente, Guadalajara, Jalisco, Mexico
    Blood Cells Mol Dis 33:326-9. 2004
    We studied the role of cytochrome P4501A1 (CYP1A1 Val/Val) genotypes in the etiology of acute lymphoblastic leukemia (ALL) in adult Mexican patients...
  94. ncbi [Study on the relationship between polymorphisms of Cyp1A1, GSTM1, GSTT1 genes and the susceptibility to acute leukemia in the general population of Hunan province]
    Qing Xia Liu
    Molecular Biology Research Center, Xiangya School of Medicine, Central South University, Changsha 410078, China
    Zhonghua Liu Xing Bing Xue Za Zhi 26:975-9. 2005
    Based on the distribution of genetic polymorphisms regarding phase I metabolic enzyme cytochrome P450 1A1 (CYP1A1) and phase II metabolic enzymes glutathione S-transferase GSTM1 and GSTT1 genotypes in acute leukemia patients and health ..
  95. ncbi Identification of cytochrome P450 1A1 in human brain
    C H Yun
    Department of Biochemistry, Pai Chai University, Taejon, Korea
    Biochem Biophys Res Commun 243:808-10. 1998
    ..We demonstrated for the first time that human brain contains a P450 1A1-dependent metabolism system which seems to be important for understanding the metabolism of endogenous and exogenous compounds...
  96. ncbi Association of CYP1A1 germ line polymorphisms with mutations of the p53 gene in lung cancer
    K Kawajiri
    Department of Biochemistry, Saitama Cancer Center Research Institute, Japan
    Cancer Res 56:72-6. 1996
    We reported an association of smoking-induced lung cancer susceptibility with the human cytochrome P450 1A1 (CYP1A1) polymorphisms in our previous studies...
  97. pmc An association between BPDE-like DNA adduct levels and CYP1A1 and GSTM1 polymorphisma in pterygium
    Jai Nien Tung
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Mol Vis 16:623-9. 2010
    ..Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic ..
  98. doi Polymorphisms in CYP1A1 and ethnic-specific susceptibility to acute lymphoblastic leukemia in children
    Ryan M Swinney
    Department of Pediatrics and Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Epidemiol Biomarkers Prev 20:1537-42. 2011
    ..Previous reports have shown an association between CYP1A1 variants and ALL.
  99. doi Lack of significant association between CYP1A1 T3801C polymorphism and breast cancer risk: a meta-analysis involving 25,087 subjects
    Lei Yao
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, People s Republic of China
    Breast Cancer Res Treat 122:503-7. 2010
    ..To date, many publications have evaluated the correlation between cytochrome P450 1A1 (CYP1A1) T3801C polymorphism and breast cancer risk. However, the results remain inconclusive...
  100. ncbi Polymorphisms in CYP1A1 and breast carcinoma risk in a population-based case-control study of Chinese women
    Sonia M Boyapati
    Department of Medicine, Center for Health Services Research, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer 103:2228-35. 2005
    Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma.
  101. ncbi The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers
    Bo Chen
    Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, 200032, PR China
    Sci Total Environ 381:38-46. 2007
    ..No influence was found in the association between urinary 1-OHP and other genetic polymorphisms such as CYP1A1, CYP1A2, CYP1B1, CYP2E1, EPHX1, EPHX2 in this population.

Research Grants67

  1. CYP1A1 GENOTYPE & INDUCIBIL PHENOTYPE-HUM LUNG CA RISK
    Jennifer Hu; Fiscal Year: 1992
    ..The working hypothesis is that the measurements of CYP1A1 enzyme inducibility in HMLs may at least in part reflect the biological responses in the target lung tissue...
  2. Genetic Susceptibility Factors in Porphyria Cutanea Tarda (PCT)
    Karl Anderson; Fiscal Year: 2009
    ..DNA samples will be prepared from patients and controls and genotyped for specific CYP1A1, CYP1A2, CYP2E1, GSTM1 and GSTT1 polymorphisms, and the results analyzed as related to phenotype (e.g...
  3. Modulation of AhR-dependent signaling by PPARb/d
    Jeffrey M Peters; Fiscal Year: 2010
    ..In the absence of PPAR/ expression, increased expression of CYP1B1 and CYP1A1 and some phase II enzymes does not occur after application of PAHs...
  4. Early Disease Biomarkers of PCB-exposed Human Population
    Sisir K Dutta; Fiscal Year: 2010
    ..PCBs and metabolites of PCBs that have been isolated from human blood and tissues, and the gene cytochrome P450 (CYP1A1), which mediates production of OH-PCB by oxidative metabolism, has been found to be 65-fold increased by PCB-77 in ..
  5. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    MICHAEL THOMAS FASULLO; Fiscal Year: 2010
    ..Cytochrome P450 genes, such as CYP1A1, CYP1A2, CYP3A4, and CYP3A5 encode proteins that activate potent liver carcinogens into genotoxic epoxides...
  6. Role of hepatic and pulmonary P4501A enzymes in neonatal hyperoxic tissue injury
    XANTHI IOANNA COUROUCLI; Fiscal Year: 2013
    ..the hypothesis that prenatal or postnatal exposure of wild type (WT) (C57BL/6J) mice to the cytochrome P4501A1 (CYP1A1) inducer beta-naphthoflavone (BNF) will result in attenuation or potentiation, respectively, of acute lung and ..
  7. MOLECULAR MECHANISMS OF COMPLEX MIXTURE TOXICITY
    Alvaro Puga; Fiscal Year: 2013
    ..These changes inhibit recruitment of RNA polymerase II to the Cyp1a1 promoter, block BaP-inducible gene expression and stimulate the formation of BPDE-DNA adducts...
  8. Genomic profiling of yeast resistance to AFB1, a P450-activated carcinogen
    MICHAEL THOMAS FASULLO; Fiscal Year: 2013
    ..We previously were successful in introducing human CYP1A2 and CYP1A1 into yeast and activating a variety of carcinogens, including aflatoxin B1 (AFB1), benzo[a]pyrene dihydrodiol (BaP-..
  9. Role of IGF-1R in breast cancer proliferation and survival via CYP1A1 epoxygenase
    MARIANGELLYS RODRIGUEZ; Fiscal Year: 2012
    ..The results will advance the breast cancer field by characterizing the biological mechanism by which the metabolism of dietary omega-3 fatty acids is regulated by insulin-like growth factors to promote the growth of breast cancer. ..
  10. Molecular mechanism of cytochrome P4501A1 expression.
    Bhagavatula Moorthy; Fiscal Year: 2013
    ..The central hypothesis of this application is that CYP1A1 and CYP1A2 enzymes play reciprocal roles in PAH-mediated carcinogenesis, and that a CYP1A2-dependent MC metabolite(..
  11. The Effect of Dietary Fat on Benzo(a)pyrene Induced Colon Cancer in Apc Min Mice
    DEACQUNITA LAQUADE DIGGS; Fiscal Year: 2010
    ..The expression of cytochrome P450 family of enzymes (CYP1A1 and 1B1), and glutatione-S-transferase, the generation of reactive metabolites of BaP, their distribution, and ..
  12. A New Approach for Engineering Polyketides by Cytochrome P450 C-H Oxidation
    ROBERT VINCENT O'BRIEN; Fiscal Year: 2013
    ..We will use these ACP-P450 systems to engineer site-selective C-H oxidation of polyketides, which will expand the diversity of biologically active macrolides accessible through biotic synthesis. ..
  13. Molecular Genetics of Primary Congenital Glaucoma
    Mansoor Sarfarazi; Fiscal Year: 2010
    ..During the past award period we: 1)-showed that 8 orthologous members of CYP1-3 are present during uterine development in both human and mouse;2)-created an E...
  14. A BREATH TEST FOR LUNG CANCER
    Michael Phillips; Fiscal Year: 2009
    ..Alkanes and their metabolites are metabolized rapidly by high risk cytochrome P450 phenotypes (e.g., CYP1A1, CYP1A2 and CYP2E1) whose activity is induced by polycyclic aromatic hydrocarbons in tobacco smoke...
  15. HUMAN CYTOCHROME P450 EXPRESSION--ENVIRONMENTAL EFFECTS
    RONALD HINES; Fiscal Year: 1999
    DESCRIPTION: Human cytochrome P450 CYP1A1 is not normally expressed in adult tissues...
  16. Paternal Environmental Exposures and Reproductive Outcomes: A Comparison of in Vi
    DEBORAH ANN HANSEN; Fiscal Year: 2013
    ..In vivo reproductive measures include 3.5 day post coitum (dpc): a) blastocyst numbers;b) blastocyst TUNEL, CYP1A1, and GLUT levels and localization;c) RT-PCR of in vivo blastocyst and stromal cell CYP1A1 mRNA, and d) stromal ..
  17. Cellular Determinants of Ah Receptor Signaling
    Thomas R Sutter; Fiscal Year: 2013
    ..these genes are regulated by the AHR and EGFR pathways by mechanisms similar to what has been described for CYP1A1, the prototypic AHR-regulated gene...
  18. AHR signaling in Mammalian and Non-Mammalian Models
    Mark E Hahn; Fiscal Year: 2013
    ..An inhibitor of AHR transcriptional activation function, AHR repressor (AHRR), has been identified, but its role in regulating AHR signaling remains enigmatic, and possible functions beyond ..
  19. The Aryl Hydrocarbon Receptor and Breast Cancer
    Sakina E Eltom; Fiscal Year: 2013
    ..PAH activation of AhR is implicated in carcinogenesis through induction of CYP1 family of genes with subsequent generation of reactive metabolites and activation of transcription factors...
  20. The role of the aryl hydrocarbon receptor in colon tumorigenesis
    GREGORY DEAN KENNEDY; Fiscal Year: 2012
    ..Use models of conditional activation of AHR to determine tissue autonomy of AHR signaling and susceptibility to CRC. Aim 3. Clarify the underlying mechanism of AHR-mediated tumor suppression using recombinant alleles of Arnt and Ahrr.
  21. ENDOGENOUS CYP1B1 SUBSTRATES AS AHR LIGANDS
    Craig Marcus; Fiscal Year: 2003
    ..II) The toxicological significance of prolonged Ahr-induced activation of CYP1A1, 1B1, and 1A2 expression many also be an important aspect PAH toxicity...
  22. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    ..DNA samples from mother and infant will be used to type genetic polymorphisms (CYP1A1, GSTM1, GSTT1, GSTP1, Xrcc1, XPD) relevant to the hypothesized mechanisms...
  23. PROTEIN KINASE C REGULATION OF P450 SYSTEM
    John Reiners; Fiscal Year: 2000
    ..Recent analyses of the expression of select members (Cyp1a1, Cyp1b1, Adhd4, and Nmo1) of the Ah battery in cells transfected with an oncogenic Ha-ras gene, or treated with 12-..
  24. STUDIES ON THE HALOGENATED AROMATIC HYDROCARBONS
    ALAN POLAND; Fiscal Year: 1990
    ..The induction of the microsomal monooxygenase, aryl hydrocarbon hydroxylase (AHH) activity, and other coordinately expressed enzymes, and the characteristic toxic responses of ..
  25. PCB Disruption of Thyroid Hormone Action during Development
    ROBERT THOMAS ZOELLER; Fiscal Year: 2013
    ..AhR-null and CYP1A1-null mice will be employed to confirm the role of AhR and CYP in the generation of PCB metabolites and effects on ..
  26. Molecular Analysis of Esophageal Cancer Survival
    Matthew Kulke; Fiscal Year: 2007
    ..the association between overall survival and the presence of specific genetic polymorphisms (GSTP1, GSTM1, GSTT1, CYP1A1, CYP3A5, p53, XRCC1 and ERCC2) in patients with esophageal cancer...
  27. c-Myc transcription in intestinal growth, differentiation, and carcinogenesis
    Gregory S Yochum; Fiscal Year: 2012
    ..LoxP technology, making use of a -naphthoflavone-sensitive Cre recombinase under control of the intestine-specific CYP1A1 promoter...
  28. Human CYP1A1, diet and dioxin-induced hypertension
    Mary K Walker; Fiscal Year: 2012
    ..Exposure to HAHs highly induces cytochrome P4501A1 (CYP1A1) and notably, ?-3 PUFAs are the preferred endogenous fatty acid substrates for CYP1A1...
  29. Cytochrome P4501A1 and Vascular Injury
    Mary K Walker; Fiscal Year: 2012
    ..is a significant source of ROS and is highly induced in the vasculature by chemicals in TS is cytochrome P4501A1 (CYP1A1)...
  30. Regulation of cyp1a1 by Ah Receptor and NFkB Interaction
    Yanan Tian; Fiscal Year: 2009
    ..In AIM I of this proposal we will investigate a mechanism in which AhR/NF-kB interaction regulates cyp1a1 transcription elongation by directly interacting with p-TEFb (positive transcription elongation factor b), which ..
  31. CYP1B1 and Retinopathy of Prematurity
    Nader Sheibani; Fiscal Year: 2010
    ..Although lack of CYP1 B1 is shown to influence the function and development of the trabecular meshwork...
  32. Test to Predict Effectiveness of Docetaxel Treatment
    Carol Swartz; Fiscal Year: 2013
    ..The focus of Objective 1 is the development and validation of a CYP1 81 *3 genotype assay using a PCR based Taqman allelic discrimination technique suitable for eventual use in a GLP/..
  33. Polycyclic Aromatic Hydrocarbons And Male Reproductive Health
    HUEIWANG ANNA COOK JENG; Fiscal Year: 2010
    ..characterize coke-oven workers'sperm quality, quantify PAH biomarker levels, and detect allelic variants in CYP1A1 and GSTM1 genes. Urine samples will be collected for determining PAH internal exposure levels...
  34. Sarcoidosis in U.S. Black Women: Genetic and Non-genetic Risk Factors
    Yvette C Cozier; Fiscal Year: 2012
    ..in the synthesis of sex steroids (CYP17, CYP19), and the metabolism and detoxification of estrogen (COMT, CYP1B1, CYP1A1, ESR1), in relation to sarcoidosis risk...
  35. PHARMACOGENETICS OF DRUG AND CARCINOGEN METABOLISM
    David Hein; Fiscal Year: 2009
    ..stable transfection of human NAT1 or NAT2 variant alleles into Chinese hamster ovary cells transfected with human CYP1A1 or CYP1B1;determine the relative level of NAT1 and NAT2 expression in normal human mammary tissue as a function of ..
  36. THE NEUROENDOCRINE CONTROL OF REPRODUCTION IN THE HUMAN
    William Francis Crowley; Fiscal Year: 2012
    ..Hypogonadotropic Hypogonadism (nIHH), Kallmann's Syndrome (KS) and Acquired Hypogonadotropic Aypogonadism (AHH)...
  37. Cytochrome-P-450 genes in pathobiology of endometrial cancer
    Rajvir Dahiya; Fiscal Year: 2009
    The main goal of this project is to investigate whether the cytochrome P4501A1 (CYP1A1) and cytochrome P4501B1 (CYP1B1) genes are risk factors for pathobiology of endometrial cancer...
  38. Molecular mechanisms of cytochrome P4501A regulation by hyperoxia
    Bhagavatula Moorthy; Fiscal Year: 2010
    ..ii) To test the hypothesis that humanized CYP1A1 mice [hCYP1A1-Cyp1a1 (-/-)], or hCYP1A1_1A2-Cyp1a1/1a2 (-/-)] mice on will be more tolerant to hyperoxic injury, ..
  39. Toxicological Control Mechanisms of Human CYP1A2
    LINDA QUATTROCHI; Fiscal Year: 2004
    ..CYP 1 A, one of the CYP subfamilies in vertebrates consisting of two members, CYP1A1 and CYP1A2, catalyzes the metabolism of such environmental chemicals as polycyclic aromatic hydrocarbons and ..
  40. Selective P450 Oxidation Catalysts for Synthesis of Bioactive Molecules
    Rudi Fasan; Fiscal Year: 2013
    ..In this application, we propose research aimed at developing powerful new methodologies to exploit P450 C-H oxidation catalysis and P450-mediated synthesis for selective transformation of unreactive aliphatic C-H bonds ..
  41. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..g. grilled foods &cigarette smoke. Cytochromes P450 1A1 &1B1 (CYP1A1, CYP1B1) are responsible for the metabolism of numerous PAHs, the prototype of which is benzo[a]pyrene (BaP)...
  42. REGULATION OF POLYCYCLIC AROMATIC HYDROCARBON TOXICITY
    WILLIAM HOUSER; Fiscal Year: 1992
    ..on a detailed analysis of the mechanisms which regulate the expression of an important enzyme activity, aryl hydrocarbon hydroxylase (AHH)...
  43. Roles of pulmonary and hepatic P4501A enzymes in hyperoxic lung injury in mice
    Bhagavatula Moorthy; Fiscal Year: 2010
    ..The specific aims are: (1) to test the hypothesis that hyperoxia induces CYP1A1 and 1A2 gene expression through mechanisms involving transcriptional activation of the CYP1A1 or 1A2 promoter, ..
  44. SILENCING OF CYP1A1 GENE EXPRESSION IN KERATINOCYTES
    Michael Denison; Fiscal Year: 1999
    ..agents, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is the expression of cytochrome P4501A1 (CYP1A1)...
  45. MOLECULAR EPIDEMIOLOGY OF PROSTATE CANCER
    Timothy Rebbeck; Fiscal Year: 1999
    ..These genes include cytochromes P450 (e.g. CYP1A1, CYP2D6, and CYP2E1) and the mu or theta classes of the glutathione-S-transferases...
  46. PCBs, CYP1A1 Polymorphism and Breast Cancer Risk in CT
    Tongzhang Zheng; Fiscal Year: 2002
    ..strong inducers of key genes involved in steroid metabolism and xenobiotic metabolism, such as human cytochrome CYP1A1. Recent epidemiological studies suggest that women are at increased risk of breast cancer if they have an elevated ..
  47. ABNORMAL FETAL DEVELOPMENT DUE TO TOXIC EXPOSURE
    MRINAL SANYAL; Fiscal Year: 1991
    ..g., benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene). Benzo[a]pyrene hydroxylase (Aryl hydrocarbon hydroxylase) and other mixed function oxidase (MFO) enzyme activities are to be measured in human placental tissues ..
  48. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    Michael Fasullo; Fiscal Year: 2007
    ..Cytochrome P450 genes, such as CYP1A1, CYP1A2, CYP3A4, and CYP3A5 encode proteins that activate potent liver carcinogens into genotoxic epoxides...
  49. ENDOMETRIAL CANCER AND CYP1A1, GSTM1 AND POLYMORPHISMS
    Noel Weiss; Fiscal Year: 1999
    ..The genes of interest are: cytochrome P450 1A1 (CYP1A1), glutathione-S-transferases M1 (GSTM1) and T1 (GSTT1), and catechol-O-methyltransferase (COMT)...
  50. ENVIRONMENTAL AND GENETIC DETERMINANTS OF BREAST CANCER
    Mary Wolff; Fiscal Year: 1993
    ..The relationship of breast cancer to genetic polymorphisms in carcinogen metabolizing genes (CYP1A1, CYP1A2, CYP2E1, GST) will be determined...
  51. RETINOIDS AND THE ARYLHYDROCARBON RECEPTOR PATHWAY
    DIANNE SOPRANO; Fiscal Year: 2003
    ..Preliminary data demonstrate that one non-isoprenoid retinoid, AGN193109, can elevate the level of CYP1A1 mRNA in mouse embryos and Hepa-1c1c7 cells...
  52. Validation of Biomarkers in Humans Exposed to PAHs
    Qingshan Qu; Fiscal Year: 2004
    ..In addition, the polymorphisms of genes, including CYP1A1, microsomal epoxide hydrolase (mEH), GSTM1, and p53 genes, will be identified to assess gene-environment ..
  53. BREAST CANCER AND GENE POLYMORPHISMS IN CHINESE WOMEN
    Chu Chen; Fiscal Year: 2003
    ..of a number of genes involved in the biosynthesis and catabolism of estrogens (CYP11a, CYP17, EDH17beta2, CYP1A1, CYP1A2, CYP1B1, COMT), and those for the androgen receptor, estrogen receptor and IGF-I genes are related to the ..
  54. CYP1A1, estrogen metabolism and ovarian carcinogenesis
    Shuk Mei Ho; Fiscal Year: 2004
    ..Recently, we have demonstrated a) overexpression of CYP1A1 enzyme, but not CYP1B1 enzyme, in epithelial OC specimens, b) increased transcription of CYP1A1 in epithelial OC ..
  55. CYP1A1 and CYP1B1 genes in race-related Prostate Cancer
    Rajvir Dahiya; Fiscal Year: 2007
    ..Under this specific aim, we will analyze single nucleotide polymorphisms of four polymorphic sites of the CYPIA1 gene and six polymorphic sites of the CYP1 B1 gene in different stages and grades of race-related prostate cancer...
  56. Adenocarinoma of the Lung in Women
    Ann Schwartz; Fiscal Year: 2005
    ..Several studies have shown that DNA adducts, p53 mutations, CYP1A1 expression in the lung, and GSTM1 null genotypes are more frequent in females than in males...
  57. CYTOCHROME P450 GENES AND THEIR REGULATION
    Robert Tukey; Fiscal Year: 1999
    ..that when activated in the presence of ligand translocates to nucleus and couples with the nuclear aryl hydrocarbon hydroxylase nuclear translocator (ARNT) protein...
  58. Polycyclic Hydrocarbons and CYP1B1 in Breast Cancer
    Colin Jefcoate; Fiscal Year: 2005
    ..that CYP1B 1 plays a major role in PAH-induced breast cancer, and that the contribution is greater than for CYP1A1 for one or more of the following reasons: (1) CYP1B1 is constitutively expressed in breast epithelia, whereas ..
  59. ETS Exposure and Genetics: Youth at Risk for CV Disease
    Martha Tingen; Fiscal Year: 2006
    ..Specific candidate genes involved in these biotransformation reactions include CYP1A1, GSTM1, GSTT1, and CYP2A6...
  60. DIOXIN TOXIC EQUIVALENCY FACTORS--BATTELLE MEMORIAL INST
    Milton Hejtmancik; Fiscal Year: 2000
    ..The relative potencies for biochemical endpoints, such as CYP1A1 induction, in the two-year studies are equivalent to the relative potency for carcinogenesis when estimated based ..
  61. Prevention of colon cancer by an AT2 receptor antagonist
    Masaaki Tamura; Fiscal Year: 2002
    ..Cytochrome P4501A1, 1A2 and 2E1 (CYP1A1, lA2 and 2E1) are major catalysts in the bioactivation of a number of putative colorectal cancer procarcinogens ..
  62. PHARMACOGENETIC DETERMINANTS OF FETAL SOMATIC MUTATION
    Marjorie Romkes; Fiscal Year: 2002
    ..focusing on the polymorphic enzymes involved in the metabolism of chemicals found in cigarette smoke, specifically CYP1A1, CYP2E1, GSTM1, GSTT1, NAT1*, and NAT2*...
  63. Estrogen Pathway Genes and Association with Prostate Cancer Risk
    Janet Stanford; Fiscal Year: 2009
    ..aromatase (CYP19A1) that converts testosterone to estrogen, and the genes that encode estrogen catabolism enzymes (CYP1A1 and CYP1B1)...
  64. BAYESIAN BIOMARKER MODELS FOR CANCER GENETICS STUDIES
    SARAH THURSTON; Fiscal Year: 2004
    ..adducts (a biomarker of smoking exposure), and genes associated with adduct formation and DNA repair (including CYP1A1 MSP1, GSTM1 and XRCC1). Currently the study has 2800 subjects, approximately half of whom are cases...
  65. REGULATION OF ARNT FUNCTION BY PHOSPHORYLATION STATUS
    Steven Levine; Fiscal Year: 1999
    ..The AhR-ARNT complex binds DNA regulatory elements upstream of the cytochrome P4501A1 (CYP1A1) gene and activates CYP1A1 expression...
  66. CYP1A1 AS A BIOMARKER OF EXPOSURE AND SUSCEPTIBILITY
    Seymour Garte; Fiscal Year: 1999
    DESCRIPTION (Adapted from the Investigator's Abstract): The focus of this project is the use of CYP1A1 gene to monitor human exposure to aromatic hydrocarbons, and to explore the molecular basis of CYP1A1 polymorphisms as cancer ..
  67. Androgen Pathway Factors and Prostate Cancer
    John Witte; Fiscal Year: 2005
    ..in the following ten androgen pathway candidate genes on prostate cancer risk: 1) CYP3A4; 2) 5a-reductase II; 3) CYP1 7; 4) the Androgen Receptor; 5) Kallikrein 3; 6) 3Beta-hydroxysteroid dehydrogenase II; 7) CYP1 la; 8) CYP19; 9) ..