CYP17A1

Summary

Gene Symbol: CYP17A1
Description: cytochrome P450 family 17 subfamily A member 1
Alias: CPT7, CYP17, P450C17, S17AH, steroid 17-alpha-hydroxylase/17,20 lyase, 17-alpha-hydroxyprogesterone aldolase, CYPXVII, cytochrome P450 17A1, cytochrome P450, family 17, subfamily A, polypeptide 1, cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia, cytochrome P450-C17, cytochrome P450c17, cytochrome p450 XVIIA1, steroid 17-alpha-monooxygenase
Species: human
Products:     CYP17A1

Top Publications

  1. Miyoshi Y, Iwao K, Ikeda N, Egawa C, Noguchi S. Genetic polymorphism in CYP17 and breast cancer risk in Japanese women. Eur J Cancer. 2000;36:2375-9 pubmed
    ..to investigate the association of two genetic polymorphisms (1931T/C and 1951G/A) in the promoter region of the CYP17 gene with breast cancer risk in Japanese women...
  2. Lee Robichaud P, Akhtar M, Wright J, Sheikh Q, Akhtar M. The cationic charges on Arg347, Arg358 and Arg449 of human cytochrome P450c17 (CYP17) are essential for the enzyme's cytochrome b5-dependent acyl-carbon cleavage activities. J Steroid Biochem Mol Biol. 2004;92:119-30 pubmed
    CYP17 (17alpha-hydroxylase-17,20-lyase; also P450c17 or P450(17alpha)) catalyses the17alpha-hydroxylation of progestogens and the subsequent acyl-carbon cleavage of the 17alpha-hydroxylated products (lyase activity) in the biosynthesis ..
  3. Takeuchi F, Isono M, Katsuya T, Yamamoto K, Yokota M, Sugiyama T, et al. Blood pressure and hypertension are associated with 7 loci in the Japanese population. Circulation. 2010;121:2302-9 pubmed publisher
    ..Significant associations were replicated for 7 loci-CASZ1, MTHFR, ITGA9, FGF5, CYP17A1-CNNM2, ATP2B1, and CSK-ULK3-with any or all of these 3 traits: systolic blood pressure (P=1.4x10(-14) to 0...
  4. Swart A, Storbeck K, Swart P. A single amino acid residue, Ala 105, confers 16alpha-hydroxylase activity to human cytochrome P450 17alpha-hydroxylase/17,20 lyase. J Steroid Biochem Mol Biol. 2010;119:112-20 pubmed publisher
    In adrenal steroidogenesis, CYP17 catalyses the 17alpha-hydroxylation of pregnenolone and progesterone and the subsequent 17,20-lyase reaction, yielding adrenal androgens...
  5. Gorai I, Tanaka K, Inada M, Morinaga H, Uchiyama Y, Kikuchi R, et al. Estrogen-metabolizing gene polymorphisms, but not estrogen receptor-alpha gene polymorphisms, are associated with the onset of menarche in healthy postmenopausal Japanese women. J Clin Endocrinol Metab. 2003;88:799-803 pubmed
    ..assays were used to determine estrogen receptor-alpha: PvuII, XbaI, and estrogen-metabolizing enzymes; CYP17, estrogen biosynthesis (high activity, A2/A2, CYP1A1), hydroxylation (high inducibility, vt/vt, and COMT), ..
  6. Garner E, Stokes E, Berkowitz R, Mok S, Cramer D. Polymorphisms of the estrogen-metabolizing genes CYP17 and catechol-O-methyltransferase and risk of epithelial ovarian cancer. Cancer Res. 2002;62:3058-62 pubmed
    Because some studies have linked polymorphic variants of the estrogen-metabolizing genes CYP17 and catechol O-methyl transferase (COMT) with risk for hormonally related cancers, we sought to determine whether selected polymorphisms of ..
  7. McKean Cowdin R, Feigelson H, Pike M, Coetzee G, Kolonel L, Henderson B. Risk of endometrial cancer and estrogen replacement therapy history by CYP17 genotype. Cancer Res. 2001;61:848-9 pubmed
    ..We examined the association between endometrial cancer risk and estrogen replacement therapy (ERT) by CYP17 genotype using 51 incident cases and 391 randomly selected controls from a multiethnic cohort in Hawaii and Los ..
  8. Dunning A, Dowsett M, Healey C, Tee L, Luben R, Folkerd E, et al. Polymorphisms associated with circulating sex hormone levels in postmenopausal women. J Natl Cancer Inst. 2004;96:936-45 pubmed
    ..Fifteen SNPs in the CYP17, CYP19, EDH17B2, SHBG, COMT, and CYP1B1 genes were genotyped in these postmenopausal women and in a breast cancer ..
  9. Asghar T, Yoshida S, Nakago S, Morizane M, Ohara N, Motoyama S, et al. Lack of association between endometriosis and the CYP17 MspA1 polymorphism in UK and Japanese populations. Gynecol Endocrinol. 2005;20:59-63 pubmed
    ..One of the genes previously implicated in the disease is CYP17; this encodes the enzyme P450c17alpha, which plays a vital role in steroid biosynthesis in the ovary...

More Information

Publications71

  1. Levy D, Ehret G, Rice K, Verwoert G, Launer L, Dehghan A, et al. Genome-wide association study of blood pressure and hypertension. Nat Genet. 2009;41:677-87 pubmed publisher
    ..n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 × 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1)..
  2. Chen Y, Pei J. Factors influencing the association between CYP17 T34C polymorphism and the risk of breast cancer: meta-regression and subgroup analysis. Breast Cancer Res Treat. 2010;122:471-81 pubmed publisher
    A number of studies have been investigated the association between CYP17 T34C polymorphism and the risk of breast cancer; the results of these studies are inconsistent, however...
  3. Yao L, Fang F, Wu Q, Yang Z, Zhong Y, Yu L. No association between CYP17 T-34C polymorphism and breast cancer risk: a meta-analysis involving 58,814 subjects. Breast Cancer Res Treat. 2010;122:221-7 pubmed publisher
    ..To date, many articles have evaluated the association between Cytochrome P450c17 (CYP17) T-34C polymorphism and breast cancer risk. However, the results remain inconclusive...
  4. Picado Leonard J, Miller W. Cloning and sequence of the human gene for P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): similarity with the gene for P450c21. DNA. 1987;6:439-48 pubmed
    b>P450c17 is a single cytochrome P450 enzyme mediating both 17 alpha-hydroxylase and 17,20 lyase activities in the biosynthesis of steroid hormones...
  5. Verla Tebit E, Wang Gohrke S, Chang Claude J. CYP17 5'-UTR MspA1 polymorphism and the risk of premenopausal breast cancer in a German population-based case-control study. Breast Cancer Res. 2005;7:R455-64 pubmed
    Studies on the association between the cytochrome P450c17alpha gene (CYP17) 5'-untranslated region MspA1 genetic polymorphism and breast cancer risk have yielded inconsistent results...
  6. Zhang L, Gu L, Qian B, Hao X, Zhang W, Wei Q, et al. Association of genetic polymorphisms of ER-alpha and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women. Breast Cancer Res Treat. 2009;114:327-38 pubmed publisher
    ..polymorphisms in the regulatory regions of ER-alpha (rs3798577) and other two estrogen-metabolizing enzyme genes CYP17 (rs743572) and CYP19 (rs10046) among 300 breast cancer cases and 390 controls in a Chinese population...
  7. Pechurskaya T, Lukashevich O, Gilep A, Usanov S. Engineering, expression, and purification of "soluble" human cytochrome P45017alpha and its functional characterization. Biochemistry (Mosc). 2008;73:806-11 pubmed
    To engineer a "soluble" form of membrane-bound cytochrome P45017alpha (CYP17)--a key enzyme in steroid hormone biosynthesis--in the present work we have built a computer model of the tertiary structure of the hemeprotein, ..
  8. Feigelson H, McKean Cowdin R, Coetzee G, Stram D, Kolonel L, Henderson B. Building a multigenic model of breast cancer susceptibility: CYP17 and HSD17B1 are two important candidates. Cancer Res. 2001;61:785-9 pubmed
    ..a nested case-control study to evaluate whether polymorphisms in two genes involved in estrogen metabolism, CYP17 and HSD17B1, were useful in developing a breast cancer risk model that could help discriminate women who are at ..
  9. Haider S, Patel J, Poojari C, Neidle S. Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy. J Mol Biol. 2010;400:1078-98 pubmed publisher
    A molecular model for the P450 enzyme cytochrome P450 C17 (CYP17) is presented based on sequence alignments of multiple template structures and homology modeling...
  10. Suzuki Y, Nagashima T, Nomura Y, Onigata K, Nagashima K, Morikawa A. A new compound heterozygous mutation (W17X, 436 + 5G --> T) in the cytochrome P450c17 gene causes 17 alpha-hydroxylase/17,20-lyase deficiency. J Clin Endocrinol Metab. 1998;83:199-202 pubmed
    A genetic disorder in cytochrome P450c17 results in 17 alpha-hydroxylase/17,20-lyase deficiency. In the present study, a Japanese patient with 17 alpha-hydroxylase/17,20-lyase deficiency underwent molecular analysis...
  11. Hefler L, Tempfer C, Grimm C, Lebrecht A, Ulbrich E, Heinze G, et al. Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women. Cancer. 2004;101:264-9 pubmed
    ..control patients revealed significantly increased and decreased risks of fibroadenoma when the mutant alleles of CYP17 (P = 0.02) and CYP1A1-1 (P = 0.04), respectively, were present...
  12. Lai J, Vesprini D, Chu W, Jernstrom H, Narod S. CYP gene polymorphisms and early menarche. Mol Genet Metab. 2001;74:449-57 pubmed
    ..We investigated whether polymorphisms of the CYP3A4, CYP17, CYP1B1, and CYP1A2 genes predict the age at onset of menarche...
  13. Yamaguchi H, Nakazato M, Miyazato M, Kangawa K, Matsukura S. A 5'-splice site mutation in the cytochrome P450 steroid 17alpha-hydroxylase gene in 17alpha-hydroxylase deficiency. J Clin Endocrinol Metab. 1997;82:1934-8 pubmed
    ..Using DNA sequencing analysis of the 17alpha-hydroxylase (CYP17) gene from a Japanese patient with 17OHD, we identified a new type of genetic abnormality in this disease, a G to ..
  14. Gudmundsdottir K, Thorlacius S, Jonasson J, Sigfusson B, Tryggvadottir L, Eyfjord J. CYP17 promoter polymorphism and breast cancer risk in males and females in relation to BRCA2 status. Br J Cancer. 2003;88:933-6 pubmed
    A T-C polymorphism in the promoter region of the CYP17 gene has been associated with male and female breast cancer risk as well as early-onset familial breast cancer...
  15. Wu A, Seow A, Arakawa K, Van Den Berg D, Lee H, Yu M. HSD17B1 and CYP17 polymorphisms and breast cancer risk among Chinese women in Singapore. Int J Cancer. 2003;104:450-7 pubmed
    ..Chinese Health Study Cohort, the relationships between polymorphisms in 2 genes involved in estrogen metabolism, CYP17 and HSD17B1, and the risk of breast cancer...
  16. Garcia Closas M, Herbstman J, Schiffman M, Glass A, Dorgan J. Relationship between serum hormone concentrations, reproductive history, alcohol consumption and genetic polymorphisms in pre-menopausal women. Int J Cancer. 2002;102:172-8 pubmed
    ..Genotypes for CYP11A 5'UTR(tttta)n, CYP17 5'-UTR -34 T>C, CYP19 IVS4(ttta)n, CYP1B1 (L432V and S453N) and COMT (V158M) were determined from genomic DNA ..
  17. Mitrunen K, Jourenkova N, Kataja V, Eskelinen M, Kosma V, Benhamou S, et al. Steroid metabolism gene CYP17 polymorphism and the development of breast cancer. Cancer Epidemiol Biomarkers Prev. 2000;9:1343-8 pubmed
    The potential role of the polymorphism in the CYP17 gene was evaluated in a case-control study with 483 incident breast cancer patients and 482 population controls, all of homogenous Finnish origin...
  18. Hong K, Jin H, Lim J, Kim S, Go M, Oh B. Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population. J Hum Genet. 2010;55:336-41 pubmed publisher
    ..Four loci-ATP2B1 (ATPase, Ca(++) transporting, plasma membrane 1), CSK (c-src tyrosine kinase), CYP17A1 (cytochrome P450 17A1) and PLEKHA7 (pleckstrin homology domain-containing family A member 7)-were associated with blood pressure ..
  19. Tiosano D, Knopf C, Koren I, Levanon N, Hartmann M, Hochberg Z, et al. Metabolic evidence for impaired 17alpha-hydroxylase activity in a kindred bearing the E305G mutation for isolate 17,20-lyase activity. Eur J Endocrinol. 2008;158:385-92 pubmed publisher
    The CYP17A1 gene encodes many enzymatic reactions including 17alpha-hydroxylase and 17,20-lyase activities...
  20. Bhangoo A, Aisenberg J, Chartoffe A, Ten S, Wallerstein R, Wolf R, et al. Novel mutation in cytochrome P450c17 causes complete combined 17alpha-hydroxylase/17,20-lyase deficiency. J Pediatr Endocrinol Metab. 2008;21:185-90 pubmed
    b>Cytochrome P450c17 (CYP17) has two principal enzyme activities, 17alpha-hydroxylase and 17,20-lyase, which are required for cortisol and androgen biosynthesis, respectively...
  21. Olson S, Bandera E, Orlow I. Variants in estrogen biosynthesis genes, sex steroid hormone levels, and endometrial cancer: a HuGE review. Am J Epidemiol. 2007;165:235-45 pubmed
    ..Little or no association was found between genotypes of the cytochrome P-450 genes CYP11A1 (-528[TTTTA]n) or CYP17A1 (-34T/C) or the 17beta-hydroxysteroid dehydrogenase 1 gene HSD17B1 (Ser312Gly) and levels of progesterone, ..
  22. Chang J, Gertig D, Chen X, Dite G, Jenkins M, Milne R, et al. CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors: Australian Breast Cancer Family Study. Breast Cancer Res. 2005;7:R513-21 pubmed
    Because CYP17 can influence the degree of exposure of breast tissues to oestrogen, the interaction between polymorphisms in this gene and hormonal risk factors is of particular interest...
  23. Rosa S, Steigert M, Lang Muritano M, l Allemand D, Schoenle E, Biason Lauber A. Clinical, genetic and functional characteristics of three novel CYP17A1 mutations causing combined 17alpha-hydroxylase/17,20-lyase deficiency. Horm Res Paediatr. 2010;73:198-204 pubmed publisher
    ..Four mutations were identified by sequencing of the CYP17A1 gene: I332T and A355T in the less severely affected patient; G111S and R440H in the patient with complete lack of ..
  24. Hofland J, Van Weerden W, Dits N, Steenbergen J, van Leenders G, Jenster G, et al. Evidence of limited contributions for intratumoral steroidogenesis in prostate cancer. Cancer Res. 2010;70:1256-64 pubmed publisher
    ..Simultaneous but low expression of the enzymes CYP17A1 and HSD3B1, essential for the synthesis of androgens from pregnenolone, could be detected in 19 of 88 patient ..
  25. Chacko P, Rajan B, Mathew B, Joseph T, Pillai M. CYP17 and SULT1A1 gene polymorphisms in Indian breast cancer. Breast Cancer. 2004;11:380-8 pubmed
    ..The CYP17 and SULT1A1 genes encode for two enzymes involved in hormone biosynthesis and metabolism...
  26. Geller D, Auchus R, Mendonca B, Miller W. The genetic and functional basis of isolated 17,20-lyase deficiency. Nat Genet. 1997;17:201-5 pubmed
    ..because 17 alpha-hydroxylase and 17,20-lyase activities are catalyzed by a single enzyme, microsomal cytochrome P450c17, and because the index case of apparent isolated 17,20-lyase deficiency had combined deficiencies of both ..
  27. Biason Lauber A, Kempken B, Werder E, Forest M, Einaudi S, Ranke M, et al. 17alpha-hydroxylase/17,20-lyase deficiency as a model to study enzymatic activity regulation: role of phosphorylation. J Clin Endocrinol Metab. 2000;85:1226-31 pubmed
    Cytochrome P450 17alpha-hydroxylase (CYP17) is a single gene-encoded protein with two activities: 17alpha-hydroxylase and 17,20-lyase. The two catalytic activities are differentially regulated in health and disease...
  28. Spurdle A, Hopper J, Dite G, Chen X, Cui J, McCredie M, et al. CYP17 promoter polymorphism and breast cancer in Australian women under age forty years. J Natl Cancer Inst. 2000;92:1674-81 pubmed
    ..hormone levels have been reported to be associated with a T to C polymorphism in the 5' promoter region of the CYP17 gene...
  29. Tan W, Qi J, Xing D, Miao X, Pan K, Zhang L, et al. [Relation between single nucleotide polymorphism in estrogen-metabolizing genes COMT, CYP17 and breast cancer risk among Chinese women]. Zhonghua Zhong Liu Za Zhi. 2003;25:453-6 pubmed
    To test the hypothesis whether polymorphism in estrogen-metabolizing genes, COMT and CYP17, impacts on the risk of breast cancer among Chinese women...
  30. Sherbet D, Tiosano D, Kwist K, Hochberg Z, Auchus R. CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding. J Biol Chem. 2003;278:48563-9 pubmed
    b>Cytochrome p450c17 (CYP17) converts the C21 steroids pregnenolone and progesterone to the C19 androgen precursors dehydroepiandrosterone (DHEA) and androstenedione, respectively, via sequential 17alpha-hydroxylase and 17,20-lyase ..
  31. Sharp L, Cardy A, Cotton S, Little J. CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors. a HuGE review. Am J Epidemiol. 2004;160:729-40 pubmed
    The cytochrome P-450c17alpha (CYP17 ) gene, located on chromosome 10q24.3, encodes the enzyme cytochrome P-450c17alpha, which functions at key branch points in steroid hormone biosynthesis...
  32. Tworoger S, Chubak J, Aiello E, Ulrich C, Atkinson C, Potter J, et al. Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women. Cancer Epidemiol Biomarkers Prev. 2004;13:94-101 pubmed
    ..Several genetic polymorphisms that may influence sex hormone concentrations have been identified, including CYP17 (5'-untranslated region T-->C), CYP19 [intron 4 (TTTA)(n = 7-13) and a 3-bp deletion (-3)], CYP1B1 (Val(432)Leu)..
  33. Imai T, Globerman H, Gertner J, Kagawa N, Waterman M. Expression and purification of functional human 17 alpha-hydroxylase/17,20-lyase (P450c17) in Escherichia coli. Use of this system for study of a novel form of combined 17 alpha-hydroxylase/17,20-lyase deficiency. J Biol Chem. 1993;268:19681-9 pubmed
    Enzymatically active human 17 alpha-hydroxylase cytochrome P450 (P450c17) has been expressed in and purified from Escherichia coli...
  34. Haiman C, Hankinson S, Colditz G, Hunter D, De Vivo I. A polymorphism in CYP17 and endometrial cancer risk. Cancer Res. 2001;61:3955-60 pubmed
    Among women, the A2 allele of CYP17 has been associated with elevated levels of endogenous steroid hormones; however, it does not seem to be a strong independent risk factor for breast cancer...
  35. Gupta M, Geller D, Auchus R. Pitfalls in characterizing P450c17 mutations associated with isolated 17,20-lyase deficiency. J Clin Endocrinol Metab. 2001;86:4416-23 pubmed
    The cytochrome P450c17 enzyme system performs both the 17alpha-hydroxylase and 17,20-lyase reactions in the human adrenal glands and gonads...
  36. Ye Z, Parry J. The CYP17 MspA1 polymorphism and breast cancer risk: a meta-analysis. Mutagenesis. 2002;17:119-26 pubmed
    ..The CYP17 gene encodes P450c17alpha, an enzyme that is involved in the metabolism of steroid hormones...
  37. Dhir V, Reisch N, Bleicken C, Lebl J, Kamrath C, Schwarz H, et al. Steroid 17alpha-hydroxylase deficiency: functional characterization of four mutations (A174E, V178D, R440C, L465P) in the CYP17A1 gene. J Clin Endocrinol Metab. 2009;94:3058-64 pubmed publisher
    Steroid 17alpha-hydroxylase (CYP17A1, alias P450c17) deficiency (17OHD) is a rare form of congenital adrenal hyperplasia. The CYP17A1 enzyme catalyzes two distinct reactions, 17alpha-hydroxylase and 17,20-lyase activities...
  38. Van Den Akker E, Koper J, Boehmer A, Themmen A, Verhoef Post M, Timmerman M, et al. Differential inhibition of 17alpha-hydroxylase and 17,20-lyase activities by three novel missense CYP17 mutations identified in patients with P450c17 deficiency. J Clin Endocrinol Metab. 2002;87:5714-21 pubmed
    The microsomal enzyme cytochrome P450c17 is an important regulator of steroidogenesis. The enzyme has two functions: 17alpha-hydroxylase and 17,20-lyase activities...
  39. Artamonov V, Liubchenko L, Shabanov M, Babenko O, Nemtsova M, Zaletaev D. [Association of polymorphism of genetic markers of CYP19 and CYP17 with sporadic breast cancer]. Mol Biol (Mosk). 2003;37:975-82 pubmed
    Polymorphic alleles of CYP17 and CYP19, which are involved in estrogen biosynthesis, were tested for association with breast cancer (BC)...
  40. Naffin Olivos J, Auchus R. Human cytochrome b5 requires residues E48 and E49 to stimulate the 17,20-lyase activity of cytochrome P450c17. Biochemistry. 2006;45:755-62 pubmed
    b>Cytochrome P450c17 (CYP17) catalyzes both the 17alpha-hydroxylase and 17,20-lyase reactions in human steroid biosynthesis...
  41. Chen Y, Gammon M, Teitelbaum S, Britton J, Terry M, Shantakumar S, et al. Estrogen-biosynthesis gene CYP17 and its interactions with reproductive, hormonal and lifestyle factors in breast cancer risk: results from the Long Island Breast Cancer Study Project. Carcinogenesis. 2008;29:766-71 pubmed publisher
    ..We examined the effect of the CYP17 promoter T --> C polymorphism and its interactions with the reproductive history, exogenous hormone use and ..
  42. Chakraborty A, Murthy N, Chintamani C, Bhatnagar D, Mohil R, Sharma P, et al. CYP17 gene polymorphism and its association with high-risk north Indian breast cancer patients. J Hum Genet. 2007;52:159-65 pubmed
    A single T > C change at the 5' promoter region of the CYP17 gene is reported to be associated with increased risk of breast cancer. This study evaluates the influence of genetic polymorphism of CYP17 on breast cancer susceptibility...
  43. Ambrosone C, Moysich K, Furberg H, Freudenheim J, Bowman E, Ahmed S, et al. CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors. Breast Cancer Res. 2003;5:R45-51 pubmed
    Findings from previous studies regarding the association between the CYP17 genotype and breast cancer are inconsistent...
  44. Hong C, Thompson H, Jiang C, Hammond G, Tritchler D, Yaffe M, et al. Association between the T27C polymorphism in the cytochrome P450 c17alpha (CYP17) gene and risk factors for breast cancer. Breast Cancer Res Treat. 2004;88:217-30 pubmed
    ..A T27C polymorphism (alleles A1 and A2, respectively) in the 5' promoter region of CYP17 may be associated with elevated sex hormone levels...
  45. Yanase T, Sanders D, Shibata A, Matsui N, Simpson E, Waterman M. Combined 17 alpha-hydroxylase/17,20-lyase deficiency due to a 7-basepair duplication in the N-terminal region of the cytochrome P45017 alpha (CYP17) gene. J Clin Endocrinol Metab. 1990;70:1325-9 pubmed
    ..The complete exonic sequence of the patient's CYP17 (P45017 alpha) gene revealed a seven-basepair duplication (GCGCACA) in exon 2 which leads to a frame shift and, ..
  46. Goode E, Dunning A, Kuschel B, Healey C, Day N, Ponder B, et al. Effect of germ-line genetic variation on breast cancer survival in a population-based study. Cancer Res. 2002;62:3052-7 pubmed
    ..0 and became nonsignificant (P = 0.4). CYP17 (P = 0.05) and TP53 (P = 0.06) polymorphisms showed marginally significant associations in unstratified analyses...
  47. Biran D, Braw Tal R, Gendelman M, Lavon Y, Roth Z. ACTH administration during formation of preovulatory follicles impairs steroidogenesis and angiogenesis in association with ovulation failure in lactating cows. Domest Anim Endocrinol. 2015;53:52-9 pubmed publisher
    ..3β-hydroxysteroid dehydrogenase, cytochrome P450 aromatase (P450arom), and cytochrome P450 17α-hydroxylase (P450c17) were lower (P < 0.02) in the ACTH-treated vs control cows...
  48. Levran D, Ben Shlomo I, Pariente C, Dor J, Mashiach S, Weissman A. Familial partial 17,20-desmolase and 17alpha-hydroxylase deficiency presenting as infertility. J Assist Reprod Genet. 2003;20:21-8 pubmed
    ..Its exact nature and prevalence remain to be determined. ..
  49. Simonov A, Holien J, Yeung J, Nguyen A, Corbin C, Zheng J, et al. Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1). PLoS ONE. 2015;10:e0141252 pubmed publisher
    b>Cytochrome P450c17 (P450 17A1, CYP17A1) is a critical enzyme in the synthesis of androgens and is now a target enzyme for the treatment of prostate cancer...
  50. Haznedaroglu I, Malkan U. Local bone marrow renin-angiotensin system in the genesis of leukemia and other malignancies. Eur Rev Med Pharmacol Sci. 2016;20:4089-4111 pubmed
    ..ace2, agt, agtr1, agtr2, akr1c4, akr1d1, anpep, atp6ap2, cma1, cpa3, ctsa, ctsd, ctsg, cyp11a1, cyp11b1, cyp11b2, cyp17a1, cyp21a2, dpp3, egfr, enpep, gper, hsd11b1, hsd11b2, igf2r, klk1, lnpep, mas1, mme, nr3c1, nr3c2, prep, ren, ..
  51. Han W, Xie W, Zhang Y, Zhang F, Zhang H, Han Y, et al. Seasonal expression of P450c17 and 5?-reductase-2 in the scented gland of male muskrats (Ondatra zibethicus). Gen Comp Endocrinol. 2017;254:60-67 pubmed publisher
    b>Cytochrome P450 17A1 (P450c17) is the key enzyme required for the production of androgenic sex steroids by converting progestogens to androgens...
  52. Goto M, Brickwood S, Wilson D, Wood P, Mason J, Hanley N. Steroidogenic enzyme expression within the adrenal cortex during early human gestation. Endocr Res. 2002;28:641-5 pubmed
    ..Vascular development was apparent within the adrenal gland at 41 dpc. CYP11A and CYP17 were expressed centrally within the fetal zone at 50 dpc and all later time points during the first trimester...
  53. Dwivedi S, Agrawal S, Singh S, Madeshiya A, Singh D, Mahdi A, et al. Association of Cytochrome-17 (MspA1) Gene Polymorphism with Risk of Gall Bladder Stones and Cancer in North India. Asian Pac J Cancer Prev. 2015;16:5557-63 pubmed
    ..b>Cytochrome P450C17α (CYP-17) is a key enzyme involved in estrogen metabolism and polymorphisms in CYP-17 are associated with ..
  54. Zolottsev V, Tkachev Y, Latysheva A, Kostin V, Novikov R, Timofeev V, et al. Comparison of [17(20)E]-21-Norpregnene oxazolinyl and benzoxazolyl derivatives as inhibitors of CYP17A1 activity and prostate carcinoma cells growth. Steroids. 2018;129:24-34 pubmed publisher
    ..of steroid moiety, were synthesized and evaluated for their potency to inhibit 17α-hydroxylase/17,20-lyase (CYP17A1) activity...
  55. Polotti C, Kim C, Chuchvara N, Polotti A, Singer E, Elsamra S. Androgen deprivation therapy for the treatment of prostate cancer: a focus on pharmacokinetics. Expert Opin Drug Metab Toxicol. 2017;:1-9 pubmed publisher
    ..and second-line use: antiandrogens, estrogens, luteinizing hormone-releasing hormone agonists/antagonists, and CYP17 inhibitors...
  56. Huang P, Li W, Liao P, Sun C, Tsai E, Wang S. Risk for estrogen-dependent diseases in relation to phthalate exposure and polymorphisms of CYP17A1 and estrogen receptor genes. Environ Sci Pollut Res Int. 2014;21:13964-73 pubmed publisher
    ..These genes include CYP17A1, estrogen receptor 1 (ESR1), and 2 (ESR2)...
  57. Kaufman B, Laitman Y, Ziv E, Hamann U, Torres D, Lahad E, et al. The CYP17A1 -34T > C polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat. 2011;126:521-7 pubmed publisher
    ..A polymorphism (-34 T > C; rs743572) in the cytochrome P450c17alpha gene (CYP17A1) encoding an enzyme which controls estrogen levels was reportedly associated with breast cancer risk in average ..
  58. Syamala V, Syamala V, Sheeja V, Kuttan R, Balakrishnan R, Ankathil R. Possible risk modification by polymorphisms of estrogen metabolizing genes in familial breast cancer susceptibility in an Indian population. Cancer Invest. 2010;28:304-11 pubmed publisher
    This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk...
  59. Duell E, Holly E, Kelsey K, Bracci P. Genetic variation in CYP17A1 and pancreatic cancer in a population-based case-control study in the San Francisco Bay Area, California. Int J Cancer. 2010;126:790-5 pubmed publisher
    ..b>CYP17A1 encodes cytochrome P450c17alpha, an enzyme with 17alpha-hydroxylase and 17,20-lyase activities in estradiol ..
  60. Beuten J, Gelfond J, Franke J, Weldon K, Crandall A, Johnson Pais T, et al. Single and multigenic analysis of the association between variants in 12 steroid hormone metabolism genes and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2009;18:1869-80 pubmed publisher
    ..between prostate cancer risk and the genetic variants of 12 key genes within the steroid hormone pathway (CYP17, HSD17B3, ESR1, SRD5A2, HSD3B1, HSD3B2, CYP19, CYP1A1, CYP1B1, CYP3A4, CYP27B1, and CYP24A1)...
  61. Berstein L, Imianitov E, Gamaiunova V, Kovalevskiĭ A, Kuligina E, Belogubova E, et al. [Genetic polymorphism of steroid 17 alpha-hydroxylase/17,20-lyase (CYP17) and hyperinsulinemia in endometrial carcinoma]. Vopr Onkol. 2002;48:673-8 pubmed
    ..In the current study, we compared the role of CYP17 biallelic MspA1) polymorphism in 114 endometrial carcinoma patients and 182 healthy women...
  62. Perez M, Cerrone G, Benencia H, Márquez N, De Piano E, Frechtel G. [Polymorphism in CYP11alpha and CYP17 genes and the etiology of hyperandrogenism in patients with polycystic ovary syndrome]. Medicina (B Aires). 2008;68:129-34 pubmed
    ..Two of the candidate genes are the CYP17 and the CYP11alpha, encoding the 17-alpha-hydroxylase (P45017alpha) and the cholesterol side chain cleavage (..