Gene Symbol: CYCS
Description: cytochrome c, somatic
Alias: CYC, HCS, THC4, cytochrome c
Species: human
Products:     CYCS

Top Publications

  1. Liu X, Kim C, Yang J, Jemmerson R, Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell. 1996;86:147-57 pubmed
    ..The absorption spectrum and protein sequence revealed that this protein is cytochrome c. Elimination of cytochrome c from cytosol by immunodepletion, or inclusion of sucrose to stabilize mitochondria ..
  2. Yang J, Liu X, Bhalla K, Kim C, Ibrado A, Cai J, et al. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science. 1997;275:1129-32 pubmed
    ..Cytosolic cytochrome c is necessary for the initiation of the apoptotic program, suggesting a possible connection between Bcl-2 and ..
  3. Zou H, Henzel W, Liu X, Lutschg A, Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell. 1997;90:405-13 pubmed
    ..purification and cDNA cloning of Apaf-1, a novel 130 kd protein from HeLa cell cytosol that participates in the cytochrome c-dependent activation of caspase-3...
  4. Ferri K, Jacotot E, Blanco J, Este J, Kroemer G. Mitochondrial control of cell death induced by HIV-1-encoded proteins. Ann N Y Acad Sci. 2000;926:149-64 pubmed
    ..Signs of MMP that precede nuclear apoptosis include the translocation of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to an extra-mitochondrial localization, as well as the ..
  5. Nie Z, Phenix B, Lum J, Alam A, Lynch D, Beckett B, et al. HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation. Cell Death Differ. 2002;9:1172-84 pubmed
    ..and activates procaspase 8 in T cells which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, cleavage of DFF and PARP and, eventually, to nuclear ..
  6. Chandra D, Choy G, Deng X, Bhatia B, Daniel P, Tang D. Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death. Mol Cell Biol. 2004;24:6592-607 pubmed
    ..Cleavage of BAP31 leads to the generation of ER- localized, proapoptotic BAP20, which may mediate mitochondrion-ER cross talk through a Ca(2+)-dependent mechanism. ..
  7. Osborn Heaford H, Ryan A, Murthy S, Racila A, He C, Sieren J, et al. Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis. J Biol Chem. 2012;287:3301-12 pubmed publisher
    ..Furthermore, H(2)O(2) generation mediated by mitochondrial Rac1 requires electron transfer from cytochrome c to a cysteine residue on Rac1 (Cys-178)...
  8. Li P, Nijhawan D, Budihardjo I, Srinivasula S, Ahmad M, Alnemri E, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 1997;91:479-89 pubmed
    ..and Apaf-1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome c and dATP, an event that leads to caspase-9 activation...
  9. Yu H, Wang D, Zou L, Zhang Z, Xu H, Zhu F, et al. Proteomic alterations of brain subcellular organelles caused by low-dose copper exposure: implication for Alzheimer's disease. Arch Toxicol. 2018;92:1363-1382 pubmed publisher
    ..NADH dehydrogenase 1 alpha subcomplex subunit 10 (NDUAA), cytochrome b-c1 complex subunit Rieske (UCRI), cytochrome c oxidase subunit 5B (COX5B), and ATP synthase subunit d (ATP5H), glycolytic-related pyruvate kinase PKM (KPYM) ..

More Information

Publications142 found, 100 shown here

  1. Aslani F, Sebastian T, Keidel M, Fröhlich S, Elsässer H, Schuppe H, et al. Resistance to apoptosis and autophagy leads to enhanced survival in Sertoli cells. Mol Hum Reprod. 2017;23:370-380 pubmed publisher
    ..b>Cytochrome c release was monitored by immunofluorescence...
  2. Liao P, Liao M, Li L, Tan B, Yin Y. Effect of deoxynivalenol on apoptosis, barrier function, and expression levels of genes involved in nutrient transport, mitochondrial biogenesis and function in IPEC-J2 cells. Toxicol Res (Camb). 2017;6:866-877 pubmed publisher
    ..DNA-binding protein (mt SSB) and mitochondrial polymerase r (mt polr), NADH dehydrogenase subunit 4 (ND4) and cytochrome c oxidase (CcOX) IV, CcOX V and cytochrome c (Cyt c), mammalian silencing information regulator-2? (SIRT-1), ..
  3. Lin C, Lee H, Lee M, Pan S, Ke C, Chiu A, et al. Role of Mitochondrial DNA Copy Number Alteration in Human Renal Cell Carcinoma. Int J Mol Sci. 2016;17: pubmed publisher
    ..Protein or mRNA expression levels of TFAM; mtDNA-encoded NADH dehydrogenase subunit 1 (ND1), ND6 and cytochrome c oxidase subunit 2 (COX-2); nuclear DNA (nDNA)-encoded succinate dehydrogenase subunit A (SDHA); v-akt murine ..
  4. Cao X, Du J, Zhang Y, Yan J, Hu X. Hyperlipidemia exacerbates cerebral injury through oxidative stress, inflammation and neuronal apoptosis in MCAO/reperfusion rats. Exp Brain Res. 2015;233:2753-65 pubmed publisher
    ..Meanwhile, this study also showed that hyperlipidemia significantly enhanced cerebral I/R-induced transfer of cytochrome c from mitochondria to cytosolic and the protein expressions of Apaf-1 and caspase-3, but also decreased cerebral ..
  5. Kanbur M, Siliğ Y, Eraslan G, Karabacak M, Soyer Sarıca Z, Şahin S. The toxic effect of cypermethrin, amitraz and combinations of cypermethrin-amitraz in rats. Environ Sci Pollut Res Int. 2016;23:5232-42 pubmed publisher
    ..and hepatic drug-metabolising (cytochrome P450 2E1 (CYP2E1), NADH-cytochrome b5 reductase (CYPb5), NADPH-cytochrome c reductase/NADPH cytocrome P450 reductase (CYTC), glutathione S-transferase (GST), glutathione (GSH)) parameters ..
  6. Al Omairi N, Al Brakati A, Kassab R, Lokman M, Elmahallawy E, Amin H, et al. Soursop fruit extract mitigates scopolamine-induced amnesia and oxidative stress via activating cholinergic and Nrf2/HO-1 pathways. Metab Brain Dis. 2019;: pubmed publisher
    ..lymphoma 2 and increased the expression of the pro-apoptotic protein, Bcl-2 associated X protein, caspase-3 and cytochrome c in hippocampal neurons. SSFE pretreatment markedly ameliorated hippocampal changes...
  7. Chang X, Zheng C, Wang Y, Meng C, Xie X, Liu H. Differential protein expression using proteomics from a crustacean brine shrimp (Artemia sinica) under CO2-driven seawater acidification. Fish Shellfish Immunol. 2016;58:669-677 pubmed publisher
    ..proteins, such as peroxiredoxin, thioredoxin peroxidase, 70-kDa heat shock protein, Na/K ATPase, and ubiquinol-cytochrome c reductase; 3) immune defence-related proteins, such as prophenoloxidase and ferritin; 4) cytoskeletal-related ..
  8. Jiang Y, Li Z, Liu Y, Liu X, Chang Q, Liao Y, et al. Neuroprotective effect of water extract of Panax ginseng on corticosterone-induced apoptosis in PC12 cells and its underlying molecule mechanisms. J Ethnopharmacol. 2015;159:102-12 pubmed publisher
    ..growth arrest and DNA damage inducible protein 153 (GADD153), X-box DNA-binding protein-1 (XBP-1), caspase-12, cytochrome C, inhibitor of caspase-activated deoxyribonuclease (ICAD), caspase-3 and caspase-9 were assessed by Western Blot ..
  9. Viola Rhenals M, Patel K, Jaimes Santamaria L, Wu G, Liu J, Dou Q. Recent Advances in Antabuse (Disulfiram): The Importance of its Metal-binding Ability to its Anticancer Activity. Curr Med Chem. 2018;25:506-524 pubmed publisher
    ..This review confirms the importance of chemical features of compounds such as Disulfiram to their biological activities, and supports repurposing DSF as a potential anticancer agent. ..
  10. Yim J, Cho H, Rabkin S. Gene expression and gene associations during the development of heart failure with preserved ejection fraction in the Dahl salt sensitive model of hypertension. Clin Exp Hypertens. 2017;:1-12 pubmed publisher
    ..1 (ECE1) matrix metallopeptidase 14 (MMP14), angiotensinogen (AGT), angiotensin II receptor Type 1 (AT1R), cytochrome C oxidase I (COX1), fms-like tyrosine kinase 1 (FLT1), TIMP metallopeptidase inhibitor 2 (TIMP2), phospholamban (..
  11. Pan Y, Luo Z, Zhuo M, Wei C, Chen G, Song Y. Oxidative stress and mitochondrial dysfunction mediated Cd-induced hepatic lipid accumulation in zebrafish Danio rerio. Aquat Toxicol. 2018;199:12-20 pubmed publisher
    ..The activities of superoxide dismutase (SOD), glutathoinine peroxidase (GPx) and cytochrome c oxidase (COX) and the ATP level were significantly reduced after CdCl2 exposure...
  12. Bosch R, Alvarez Flores M, Maria D, Chudzinski Tavassi A. Hemolin triggers cell survival on fibroblasts in response to serum deprivation by inhibition of apoptosis. Biomed Pharmacother. 2016;82:537-46 pubmed publisher
    ..Our results also show an up-regulation of Bcl-2 and a down-regulation of Bax protein levels, inhibition of cytochrome c release and a reduction in caspase-3 levels, all considered critical factors for apoptosis...
  13. Wang L, Yao Y, He R, Meng Y, Li N, Zhang D, et al. Methane ameliorates spinal cord ischemia-reperfusion injury in rats: Antioxidant, anti-inflammatory and anti-apoptotic activity mediated by Nrf2 activation. Free Radic Biol Med. 2017;103:69-86 pubmed publisher
    ..MS treatment reduced neuronal apoptosis in gray matter zones, which was consistent with the suppression of cytochrome c release to the cytosol from the mitochondria and the activation of caspase-9 and -3...
  14. Lin C, Liu L, Ou L, Pan S, Lin C, Wei Y. Role of mitochondrial function in the invasiveness of human colon cancer cells. Oncol Rep. 2018;39:316-330 pubmed publisher
    ..Taken together, we conclude that higher mtDNA copy number and mitochondrial function may confer an invasive advantage to CRCs...
  15. Tian J, Lu R, Ji H, Sun J, Li C, Liu P, et al. Comparative analysis of the hepatopancreas transcriptome of grass carp (Ctenopharyngodon idellus) fed with lard oil and fish oil diets. Gene. 2015;565:192-200 pubmed publisher
    ..of mitochondrial uncoupling protein 2 (UCP2) and down-regulation of oxidative phosphorylation related genes (cytochrome c oxidase subunit 4 isoform 2 [COX4I2], HIG1 domain family member 1A [HIGD1A] and cytochrome-b5 reductase [CYB5R])..
  16. Das D, Das P, Moniruzzaman M, Poddar Sarkar M, Mukherjee J, Chakraborty S. Consequences of oxidative damage and mitochondrial dysfunction on the fatty acid profile of muscle of Indian Major Carps considering metal toxicity. Chemosphere. 2018;207:385-396 pubmed publisher
    ..succinate dehydrogenase, lactate dehydrogenase, Ca2+ATPase, AMP-deaminase, lipoamide reductase, cytochrome C oxidase, aldolase) and fatty acid composition in muscle tissues were analyzed...
  17. Wang L, Huang Q, Li Y, Huang Y, Xie J, Xu L, et al. Protective effects of silymarin on triptolide-induced acute hepatotoxicity in rats. Mol Med Rep. 2017;: pubmed publisher
    ..Therefore, silymarin may have the potential to be applied clinically to prevent TP-induced acute hepatotoxicity...
  18. Al Brakati A, Fouda M, Tharwat A, Elmahallawy E, Kassab R, Abdel Moneim A. The protective efficacy of soursop fruit extract against hepatic injury associated with acetaminophen exposure is mediated through antioxidant, anti-inflammatory, and anti-apoptotic activities. Environ Sci Pollut Res Int. 2019;26:13539-13550 pubmed publisher
    ..In addition, APAP activated the overexpression of Bax protein, increased release of cytochrome c, and the downregulation of Bcl-2 protein...
  19. Xie H, Li X, Chen Y, Lang M, Shen Z, Shi L. Ethanolic extract of Cordyceps cicadae exerts antitumor effect on human gastric cancer SGC-7901 cells by inducing apoptosis, cell cycle arrest and endoplasmic reticulum stress. J Ethnopharmacol. 2019;231:230-240 pubmed publisher
    ..The release of cytochrome c from mitochondria was associated with mitochondrial dysfunction, which was caused by the activation of the cell ..
  20. Wang Y, Su H, Song X, Fiati Kenston S, Zhao J, Gu Y. Luteolin inhibits multi-heavy metal mixture-induced HL7702 cell apoptosis through downregulation of ROS-activated mitochondrial pathway. Int J Mol Med. 2018;41:233-241 pubmed publisher
    ..The present results suggested luteolin exerts its inhibitory effects of on multi-heavy metal mixture induced cell apoptosis through downregulation of the ROS-activated mitochondrial pathway...
  21. Moraes R, Valente R, León I, Trugilho M, Pacheco A, Nobrega A, et al. Alterations of the kidney cortex proteome in response to exercise training in normoglycemic and hyperglycemic conditions. Curr Top Med Chem. 2014;14:450-61 pubmed
    ..Moreover, this protective effect could be important in the prevention of kidney vascular damage associated with diabetes pathophysiology. ..
  22. Abdel Rafei M, Amin M, Hasan H. Novel effect of Daflon and low-dose ?-radiation in modulation of thioacetamide-induced hepatic encephalopathy in male albino rats. Hum Exp Toxicol. 2016;: pubmed
    ..Moreover, hepatic apoptotic markers (cysteine-dependent aspartate-directed proteases 3, 8 (caspase-3, 8) and cytochrome C) were estimated to indicate hepatic apoptosis...
  23. Sousa L, Machado K, Oliveira S, Araújo L, Monção Filho E, Melo Cavalcante A, et al. Bufadienolides from amphibians: A promising source of anticancer prototypes for radical innovation, apoptosis triggering and Na+/K+-ATPase inhibition. Toxicon. 2017;127:63-76 pubmed publisher
    ..or S phases, mitochondrial depolarization, PARP [poly (ADPribose) polymerase] and Bid cleavages, cytochrome c release, activation of Bax and caspases (-3, -9, -8 and -10), increased expression of the Fas-Associated ..
  24. Reddy P, Yin X, Manczak M, Kumar S, Pradeepkiran J, Vijayan M, et al. Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease. Hum Mol Genet. 2018;27:2502-2516 pubmed publisher
    ..Mitochondrial function was assessed by measuring the levels of hydrogen peroxide, lipid peroxidation, cytochrome c oxidase activity and mitochondrial adenosine triphosphate...
  25. Ruan X, Chen T, Wang X, Li Y. Suxiao Jiuxin Pill protects cardiomyocytes against mitochondrial injury and alters gene expression during ischemic injury. Exp Ther Med. 2017;14:3523-3532 pubmed publisher auxiliary subunit ?2? (Cacna2d)2, Cacna2d3, calcium channel voltage-dependent ? subunit 8, cytochrome C oxidase subunit 6A2 (Cox6a2), fibroblast growth factor receptor (Fgfr) 4, Fgf8, Fgf12, Gnas complex locus, ..
  26. Roth Z. PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Cellular and molecular mechanisms of heat stress related to bovine ovarian function. J Anim Sci. 2015;93:2034-44 pubmed publisher
    ..ATP] synthase subunit beta [ATP5B]), mitochondrially NADH dehydrogenase subunit 2 (ND2), and mitochondiral (cytochrome c oxidase subunit II [MT-CO2] and cytochrome b [MT-CYB]) genes that are crucial in the mitochondrial respiratory ..
  27. Zhang C, Shen W, Zhang G. N-methyl-D-aspartate receptor and L-type voltage-gated Ca(2+) channel antagonists suppress the release of cytochrome c and the expression of procaspase-3 in rat hippocampus after global brain ischemia. Neurosci Lett. 2002;328:265-8 pubmed
    ..receptor antagonist and L-type voltage-gated Ca(2+) channel (L-VGCC) antagonist in mediating the release of cytochrome c and the expression of caspase-3 precursor protein (procaspase-3)...
  28. Castedo M, Perfettini J, Andreau K, Roumier T, Piacentini M, Kroemer G. Mitochondrial apoptosis induced by the HIV-1 envelope. Ann N Y Acad Sci. 2003;1010:19-28 pubmed
    ..Such signs include a loss of the mitochondrial transmembrane potential and the release of cytochrome c and AIF...
  29. Zhu H, Li X, Song Y, Zhang P, Xiao Y, Xing Y. Long non-coding RNA ANRIL is up-regulated in bladder cancer and regulates bladder cancer cell proliferation and apoptosis through the intrinsic pathway. Biochem Biophys Res Commun. 2015;467:223-8 pubmed publisher
    ..cell apoptosis, along with decreased expression of Bcl-2 and increased expressions of Bax, cytoplasmic cytochrome c and Smac and cleaved caspase-9, caspase-3 and PARP. However, no change of cleaved caspase-8 level was observed...
  30. Perng D, Tsai Y, Cherng J, Kuo C, Shiao C, Cherng J. Discovery of a novel anti-cancer agent targeting both topoisomerase I and II in hepatocellular carcinoma Hep 3B cells in vitro and in vivo: Cinnamomum verum component 2-methoxycinnamaldehyde. J Drug Target. 2016;24:624-34 pubmed publisher
    ..bak genes and down-regulation of anti-apoptotic bcl-2 and bcl-XL genes, mitochondrial membrane potential loss, cytochrome c release, activation of caspase 3 and 9, increase in the DNA content in sub G1, and morphological ..
  31. Banerjee K, Munshi S, Xu H, Frank D, Chen H, Chu C, et al. Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease. Neurochem Int. 2016;96:32-45 pubmed publisher
    ..protein 1A/1B-light chain 3 (LC3) from the cytosol to the mitochondria, and promoted mitochondrial cytochrome c release...
  32. Fernandes T, Costa J, Oliveira M, Mafra I. DNA barcoding coupled to HRM analysis as a new and simple tool for the authentication of Gadidae fish species. Food Chem. 2017;230:49-57 pubmed publisher
    ..Two DNA barcode regions, namely cytochrome c oxidase subunit I (COI) and cytochrome b (cytb), were analysed in silico to identify genetic variability among ..
  33. Morison I, Cramer Bordé E, Cheesman E, Cheong P, Holyoake A, Fichelson S, et al. A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia. Nat Genet. 2008;40:387-9 pubmed publisher
    We report the first identified mutation in the gene encoding human cytochrome c (CYCS)...
  34. Kamba A, Ismail M, Ibrahim T, Zakaria Z, Gusau L. In vitro ultrastructural changes of MCF-7 for metastasise bone cancer and induction of apoptosis via mitochondrial cytochrome C released by CaCO3/Dox nanocrystals. Biomed Res Int. 2014;2014:391869 pubmed publisher
    ..Apoptogenic protein Bax, cytochrome C, and caspase-3 protein were analysed...
  35. Liuni P, Deng B, Wilson D. Comparing equilibrium and kinetic protein unfolding using time-resolved electrospray-coupled ion mobility mass spectrometry. Analyst. 2015;140:6973-9 pubmed publisher
    ..Spectrometry (IMS) for the first time to directly compare equilibrium and kinetic unfolding intermediates of cytochrome c. Our results show a high degree of correlation between all species populated under these substantially ..
  36. Zhang X, Wang H, Cui J, Jiang P, Fu G, Zhong K, et al. Characterisation of the relationship between Spirometra erinaceieuropaei and Diphyllobothrium species using complete cytb and cox1 genes. Infect Genet Evol. 2015;35:1-8 pubmed publisher
    ..In this study, we determined the complete sequences of cytochrome b (cytb) and cytochrome c oxidase subunit I (cox1) genes from 61 isolates of S...
  37. Qi S, Kou X, Lv J, Qi Z, Yan L. Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through extrinsic and intrinsic pathways: Involvement of P38 and ERK. Environ Toxicol Pharmacol. 2015;40:847-54 pubmed publisher
    ..Meanwhile, the release of cytochrome c from mitochondria was observed...
  38. Asif M, Shafaei A, Jafari S, Mohamed S, Ezzat M, Abdul Majid A, et al. Isoledene from Mesua ferrea oleo-gum resin induces apoptosis in HCT 116 cells through ROS-mediated modulation of multiple proteins in the apoptotic pathways: A mechanistic study. Toxicol Lett. 2016;257:84-96 pubmed publisher
    ..e., Bid, Bim and cytochrome c. Cytochrome c in turn activated caspases cascade resulting in the induction of apoptosis...
  39. Li M, Li J, Zeng R, Yang J, Liu J, Zhang Z, et al. Respiratory Syncytial Virus Replication Is Promoted by Autophagy-Mediated Inhibition of Apoptosis. J Virol. 2018;92: pubmed publisher
    ..This study provides a novel insight into this virus-host interaction, which may help to exploit new antiviral treatments targeting autophagy processes. ..
  40. Slee E, Harte M, Kluck R, Wolf B, Casiano C, Newmeyer D, et al. Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol. 1999;144:281-92 pubmed
    Exit of cytochrome c from mitochondria into the cytosol has been implicated as an important step in apoptosis. In the cytosol, cytochrome c binds to the CED-4 homologue, Apaf-1, thereby triggering Apaf-1-mediated activation of caspase-9...
  41. Vishwakarma A, Tetali S, Selinski J, Scheibe R, Padmasree K. Importance of the alternative oxidase (AOX) pathway in regulating cellular redox and ROS homeostasis to optimize photosynthesis during restriction of the cytochrome oxidase pathway in Arabidopsis thaliana. Ann Bot. 2015;116:555-69 pubmed publisher, the role of AOX1A in optimizing photosynthesis was investigated when electron transport through the cytochrome c oxidase (COX) pathway was restricted at complex III...
  42. Behrens J, Mertens S, Krüger T, Grobelny A, Otte K, Mansow Model S, et al. Validity of visual perceptive computing for static posturography in patients with multiple sclerosis. Mult Scler. 2016;22:1596-1606 pubmed
    ..A total of 90 MS patients and 59 healthy controls (HCs) performed three stance tests: open, closed and tandem stance...
  43. Zait H, Kouidri M, Grenouillet F, Umhang G, Millon L, Hamrioui B, et al. Molecular characterization of Echinococcus granulosus sensu stricto and Echinococcus canadensis in humans and livestock from Algeria. Parasitol Res. 2016;115:2423-31 pubmed publisher
    ..Molecular characterization was performed using sequencing of two mitochondrial genes, cytochrome c oxidase subunit I (COI) and NADH dehydrogenase subunit I (NDI). In humans, G1 of E. granulosus s.s...
  44. Ahmed T, Tsuji Tamura K, Ogawa M. CXCR4 Signaling Negatively Modulates the Bipotential State of Hemogenic Endothelial Cells Derived from Embryonic Stem Cells by Attenuating the Endothelial Potential. Stem Cells. 2016;34:2814-2824 pubmed publisher
    ..ECs expressed Runx1, Tal1, Etv2, and Sox17, and contained progenitors for both ECs and hematopoietic cells (HCs) at a high frequency...
  45. Said M, Brouard I, Quintana J, Estevez F. Antiproliferative activity and apoptosis induction by 3',4'-dibenzyloxyflavonol on human leukemia cells. Chem Biol Interact. 2017;268:13-23 pubmed publisher
    ..caspases; (ii) prevented by the pan-caspase inhibitor z-VAD-fmk; (iii) associated with the release of cytochrome c and with the phosphorylation of members of the mitogen activated protein kinases including p38MAPK, ..
  46. Westwood H, Kerr Gaffney J, Stahl D, Tchanturia K. Alexithymia in eating disorders: Systematic review and meta-analyses of studies using the Toronto Alexithymia Scale. J Psychosom Res. 2017;99:66-81 pubmed publisher
    ..literature on the use of the Toronto Alexithymia Scale (TAS) in eating disorder populations and Healthy Controls (HCs) and to compare TAS scores in these groups...
  47. Raanan H, Pike D, Moore E, Falkowski P, Nanda V. Modular origins of biological electron transfer chains. Proc Natl Acad Sci U S A. 2018;115:1280-1285 pubmed publisher is possible to cluster cofactor microenvironments into as few as four major modules: bacterial ferredoxin, cytochrome c, symerythrin, and plastocyanin-type folds...
  48. Bundscherer A, Malsy M, Gruber M, Graf B, Sinner B. Acetaminophen and Metamizole Induce Apoptosis in HT 29 and SW 480 Colon Carcinoma Cell Lines In Vitro. Anticancer Res. 2018;38:745-751 pubmed
    ..Proliferation was detected by cell proliferation ELISA BrdU, and apoptosis by Annexin V staining. Cytochrome c and caspase 3, 8 and 9 expression levels were detected by western blot...
  49. Shin J, Kwon S, Bak Y, Lee S, Yoon D. BCI induces apoptosis via generation of reactive oxygen species and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells. Sci China Life Sci. 2018;61:1243-1253 pubmed publisher
    ..BCI induced processing of caspase-9, caspase-3, and poly ADP-ribose polymerase as well as the release of cytochrome c from the mitochondria into the cytosol...
  50. Kadenbach B, Hüttemann M. The subunit composition and function of mammalian cytochrome c oxidase. Mitochondrion. 2015;24:64-76 pubmed publisher
    b>Cytochrome c oxidase (COX) from mammals and birds is composed of 13 subunits...
  51. Noguchi T, Nakagome K, Kobayashi T, Ueda Y, Soma T, Nakamoto H, et al. Effect of beta2-adrenergic agonists on eosinophil adhesion, superoxide anion generation, and degranulation. Allergol Int. 2015;64 Suppl:S46-53 pubmed publisher
    ..of eosinophil superoxide anion (O2(-)) was examined based on the superoxide dismutase-inhibitable reduction of cytochrome C. Eosinophil-derived neurotoxin (EDN) release was evaluated by ELISA as a marker of degranulation...
  52. Zhang S, Chen Y, Wu X, Gao H, Ma R, Jiang C, et al. The Pivotal Role of Ca2+ Homeostasis in PBDE-47-Induced Neuronal Apoptosis. Mol Neurobiol. 2016;53:7078-7088 pubmed
    ..collapse following an early and sustained [Ca2+] i, overload, as well as stimulated cytochrome c release from mitochondria into the cytosol in SH-SY5Y cells and rat hippocampal tissue...
  53. Akshath U, Bhatt P. Tunneling of redox enzymes to design nano-probes for monitoring NAD(+) dependent bio-catalytic activity. Biosens Bioelectron. 2016;85:240-246 pubmed publisher
    ..Proposed method is advantageous over classical methods as clean up/ derivatization of samples is not required for formaldehyde detection. ..
  54. Cheng T, Hong C, Akey I, Yuan S, Akey C. A near atomic structure of the active human apoptosome. elife. 2016;5: pubmed publisher
    ..The resulting model gives insights into cytochrome c binding, nucleotide exchange and conformational changes that drive assembly...
  55. Moren C, Gonzalez Casacuberta I, Alvarez Fernández C, Bano M, Catalán García M, Guitart Mampel M, et al. HIV-1 promonocytic and lymphoid cell lines: an in vitro model of in vivo mitochondrial and apoptotic lesion. J Cell Mol Med. 2017;21:402-409 pubmed publisher
    ..This model may provide a platform for the characterization of HIV-chronicity, to test novel therapeutic options or to study HIV reservoirs. ..
  56. Gao S, Sun D, Wang G, Zhang J, Jiang Y, Li G, et al. Growth inhibitory effect of paratocarpin E, a prenylated chalcone isolated from Euphorbia humifusa Wild., by induction of autophagy and apoptosis in human breast cancer cells. Bioorg Chem. 2016;69:121-128 pubmed publisher
    ..Moreover, paratocarpin E altered the expression of Bax and Bcl-2, leading to the release of cytochrome c from the mitochondria into the cytosol, suggesting that the mitochondria-mediated apoptosis was initiated...
  57. Ucar S, Mayr J, Feichtinger R, Canda E, Coker M, Wortmann S. Previously Unreported Biallelic Mutation in DNAJC19: Are Sensorineural Hearing Loss and Basal Ganglia Lesions Additional Features of Dilated Cardiomyopathy and Ataxia (DCMA) Syndrome?. JIMD Rep. 2017;35:39-45 pubmed publisher
    ..63delC (p.Tyr21*). Investigation of enzymes of mitochondrial energy metabolism revealed decreased activity of cytochrome c oxidase in muscle tissue...
  58. Abdoul Azize S, Dubus I, Vannier J. Improvement of dexamethasone sensitivity by chelation of intracellular Ca2+ in pediatric acute lymphoblastic leukemia cells through the prosurvival kinase ERK1/2 deactivation. Oncotarget. 2017;8:27339-27352 pubmed publisher
    ..dexamethasone-induced mitochondrial membrane potential collapse, reactive oxygen species production, cytochrome c release, caspase-3 activity, and cell death...
  59. Xu Y, Qian S. Techniques for Detecting Reactive Oxygen Species in Pulmonary Vasculature Redox Signaling. Adv Exp Med Biol. 2017;967:361-372 pubmed publisher
    ..the detection of ROS in vitro and in vivo, including chemiluminescence-based assay, fluorescence-based assay, cytochrome c reduction method, genetically encoded fluorescent probes, as well as ESR spin trapping technique...
  60. Delannoy A, Wilhelm E, Eilebrecht S, Alvarado Cuevas E, Benecke A, Bell B. BIM and NOXA are mitochondrial effectors of TAF6δ-driven apoptosis. Cell Death Dis. 2018;9:70 pubmed publisher
    ..prompted us to test and validate a role for the mitochondrial pathway by showing that TAF6δ expression causes cytochrome c release into the cytoplasm...
  61. Dowe R, Vitello L, Erman J. Sedimentation equilibrium studies on the interaction between cytochrome c and cytochrome c peroxidase. Arch Biochem Biophys. 1984;232:566-73 pubmed
    The interaction between cytochrome c and cytochrome c peroxidase was investigated using sedimentation equilibrium at pH 6,20 degrees C, in a number of buffer systems varying in ionic strength between 1 and 100 mM...
  62. Gjerde B, Hilali M, Mawgood S. Molecular characterisation of three regions of the nuclear ribosomal DNA unit and the mitochondrial cox1 gene of Sarcocystis fusiformis from water buffaloes (Bubalus bubalis) in Egypt. Parasitol Res. 2015;114:3401-13 pubmed publisher
    ..Genomic DNA was extracted from the sarcocysts, and all isolates were characterised at the mitochondrial cytochrome c oxidase subunit I (cox1) gene through PCR amplification and direct sequencing, whereas a few selected isolates ..
  63. Sazmand A, Eigner B, Mirzaei M, Hekmatimoghaddam S, Harl J, Duscher G, et al. Molecular identification and phylogenetic analysis of Dipetalonema evansi (LEWIS, 1882) in camels (Camelus dromedarius) of Iran. Parasitol Res. 2016;115:1605-10 pubmed publisher
    ..Sequence analysis revealed D. evansi in all cases. Phylogenetic analysis of a cytochrome C oxidase subunit I (COI) sequence of filaroid nematodes showed that most species in a single genus cluster in ..
  64. Yoshimatsu T, D Orazi F, Gamlin C, Suzuki S, Suli A, Kimelman D, et al. Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo. Nat Commun. 2016;7:10590 pubmed publisher
    ..H3 horizontal cells (HCs) normally avoid red and green cones, and prefer ultraviolet over blue cones...
  65. da Cruz M, Weksler M. Impact of tree priors in species delimitation and phylogenetics of the genus Oligoryzomys (Rodentia: Cricetidae). Mol Phylogenet Evol. 2018;119:1-12 pubmed publisher
    ..analyses included 20 of the 24 recognized species of the genus, comprising of 416 Cytochrome b sequences, 26 Cytochrome c oxidase I sequences, and 27 Beta-Fibrinogen Intron 7 sequences...
  66. Iaffaldano P, Ribatti D, Trojano M. Natalizumab reduces serum pro-angiogenic activity in MS patients. Neurol Sci. 2018;39:725-731 pubmed publisher
    ..Plasma and serum samples of 10 treatment-naïve RRMS and 10 healthy controls (HCs) were used as controls of baseline evaluations...
  67. Hill M, Talbot C, Puddiford M, Price M. Cardiorespiratory and perceptual responses to self-regulated and imposed submaximal arm-leg ergometry. Eur J Appl Physiol. 2018;118:1011-1019 pubmed publisher
    ..Ten males (age 21.7?±?3.4 years) initially undertook incremental arm-crank ergometry (ACE) and cycle ergometry (CYC) tests to volitional exhaustion to determine peak power output (Wpeak)...
  68. Wang C, Wu H, Chen F, Xu J, Li H, Li H, et al. Disrupted functional connectivity patterns of the insula subregions in drug-free major depressive disorder. J Affect Disord. 2018;234:297-304 pubmed publisher
    ..Using the resting-state fMRI data in a group of 23 drug-free MDD patients and 34 healthy controls (HCs), we investigated whether the abnormal connectivity patterns of insular sub-regions or any behavioural correlates ..
  69. Babbitt S, Sutherland M, San Francisco B, Mendez D, Kranz R. Mitochondrial cytochrome c biogenesis: no longer an enigma. Trends Biochem Sci. 2015;40:446-55 pubmed publisher
    ..Here, we review the mechanisms of HCCS function and the roles of heme and residues in the CXXCH motif. Additionally, we consider concepts emerging within the two prokaryotic cytochrome c biogenesis pathways.
  70. Liu T, Zhou Y, Wang J, Su Q, Tang Z, Liu Y, et al. Coronary Microembolization Induces Cardiomyocyte Apoptosis in Swine by Activating the LOX-1-Dependent Mitochondrial Pathway and Caspase-8-Dependent Pathway. J Cardiovasc Pharmacol Ther. 2016;21:209-18 pubmed publisher
    ..The levels of LOX-1, Bcl-2, Bax, cytochrome c as well as cleaved caspase 9, -8, and -3 were detected...
  71. Shi P, Guy K, Wu W, Fang B, Yang J, Zhang M, et al. Genome-wide identification and expression analysis of the ClTCP transcription factors in Citrullus lanatus. BMC Plant Biol. 2016;16:85 pubmed publisher
    ..The Class II genes were differentiated into two subclasses, the CIN subclass and the CYC/TB1 subclass. The expression patterns of all members were determined by semi-quantitative PCR...
  72. Guzmán Rodríguez J, López Gómez R, Salgado Garciglia R, Ochoa Zarzosa A, López Meza J. The defensin from avocado (Persea americana var. drymifolia) PaDef induces apoptosis in the human breast cancer cell line MCF-7. Biomed Pharmacother. 2016;82:620-7 pubmed publisher
    ..In addition, PaDef IC50 induced the expression of cytochrome c, Apaf-1, and the caspase 7 and 9 genes...
  73. Eshkiki Z, Ghahremani M, Shabani P, Firuzjaee S, Sadeghi A, Ghanbarian H, et al. Protein tyrosine phosphatase 1B (PTP1B) is required for cardiac lineage differentiation of mouse embryonic stem cells. Mol Cell Biochem. 2017;425:95-102 pubmed publisher
    ..both differentiated and undifferentiated ES cells, as presented by increasing the level of cleaved caspase-3, cytochrome C, and cleaved PARP...
  74. Anzell A, Maizy R, Przyklenk K, Sanderson T. Mitochondrial Quality Control and Disease: Insights into Ischemia-Reperfusion Injury. Mol Neurobiol. 2018;55:2547-2564 pubmed publisher
    ..and, conversely, cell death via the induction of apoptosis through release of pro-apoptotic factors such as cytochrome C. Therefore, it is essential to have stringent quality control mechanisms to ensure a healthy mitochondrial ..
  75. Jiang X, Zhu X, Huang W, Xu H, Zhao Z, Li S, et al. Garlic-derived organosulfur compound exerts antitumor efficacy via activation of MAPK pathway and modulation of cytokines in SGC-7901 tumor-bearing mice. Int Immunopharmacol. 2017;48:135-145 pubmed publisher
    ..DATS also caused an increase in apoptotic cell death, which involved in accumulations of bax, p53, and cytochrome C and reduction of Bcl-2 expressions...
  76. Femnou A, Kuzmiak Glancy S, Covian R, Giles A, Kay M, Balaban R. Intracardiac light catheter for rapid scanning transmural absorbance spectroscopy of perfused myocardium: measurement of myoglobin oxygenation and mitochondria redox state. Am J Physiol Heart Circ Physiol. 2017;313:H1199-H1208 pubmed publisher
    ..This approach is a significant improvement in the quality of cardiac optical absorbance spectroscopic metabolic analyses. ..
  77. Jadhav M, Nayak M, Kumar S, Venkatesh A, Patel S, Kumar V, et al. Clinical Proteomics and Cytokine Profiling for Dengue Fever Disease Severity Biomarkers. OMICS. 2017;21:665-677 pubmed publisher
    ..with DF (n?=?12) and dengue hemorrhagic fever (DHF, n?=?24) were analyzed in comparison to healthy controls (HCs, n?=?16), using the isobaric tags for relative and absolute quantification (iTRAQ)-based quantitative proteomics ..
  78. Adams H, Sonstegard T, Vanraden P, Null D, Van Tassell C, Larkin D, et al. Identification of a nonsense mutation in APAF1 that is likely causal for a decrease in reproductive efficiency in Holstein dairy cattle. J Dairy Sci. 2016;99:6693-6701 pubmed publisher
    ..With the mutation identified, selection against the deleterious allele in breeding schemes has aided in eliminating this defect from the population, reducing carrier frequency from 8% in past decades to 2% in 2015. ..
  79. Samaiya P, Narayan G, Kumar A, Krishnamurthy S. 2,4 Dinitrophenol Attenuates Mitochondrial Dysfunction and Improves Neurobehavioral Outcomes Postanoxia in Neonatal Rats. Neurotox Res. 2018;34:121-136 pubmed publisher
    ..Furthermore, a marked decrease in the levels of expression of cytochrome C (cyt C) and pro-apoptotic (Bcl-2 family) and apoptotic (caspase-9/3) proteins was observed on day 7 indicating ..
  80. Watts C, Cooper S, Saint K. Review of Australian <i>Scirtes</i> Illiger, Ora Clark and <i>Exochomoscirtes</i> Pic Coleoptera: Scirtidae) including descriptions of new species, new groups and a multi-gene molecular phylogeny of Australian and non-Australi. Zootaxa. 2017;4347:511-532 pubmed publisher
    ..morphology, particularly male and female genitalia, larval morphology and molecular data from the mitochondrial cytochrome c oxidase subunit I (COI) gene and the nuclear genes elongation factor 1-alpha (EF1- a) and topoisomerase I (TOP1)..
  81. Sharif R, Aghsami M, Gharghabi M, Sanati M, Khorshidahmad T, Vakilzadeh G, et al. Melatonin reverses H-89 induced spatial memory deficit: Involvement of oxidative stress and mitochondrial function. Behav Brain Res. 2017;316:115-124 pubmed publisher
    ..through measuring ROS production, mitochondrial membrane potential (MMP), swelling, outer membrane damage, and cytochrome c release...
  82. Burklund L, Torre J, Lieberman M, Taylor S, Craske M. Neural responses to social threat and predictors of cognitive behavioral therapy and acceptance and commitment therapy in social anxiety disorder. Psychiatry Res Neuroimaging. 2017;261:52-64 pubmed publisher
    ..At the neural level, HCs exhibited greater activations in social pain/rejection regions, including dorsal anterior cingulate cortex and ..
  83. Kim S, Park E, Park B, Hyun J, Park N, Joung A, et al. Multimodal magnetic resonance imaging in relation to cognitive impairment in neuromyelitis optica spectrum disorder. Sci Rep. 2017;7:9180 pubmed publisher
    ..diffusion tensor, and volumetric MRI sequences were collected form 73 patients with NMOSD and 44 healthy controls (HCs). Patients with ≥3 failed tests were considered to have CI...
  84. Vygodina T, Mukhaleva E, Azarkina N, Konstantinov A. Cytochrome c oxidase inhibition by calcium at physiological ionic composition of the medium: Implications for physiological significance of the effect. Biochim Biophys Acta Bioenerg. 2017;1858:982-990 pubmed publisher
    b>Cytochrome c oxidase (CcO) from mammalian mitochondria binds Ca2+ and Na+ in a special cation binding site...
  85. McGovern M, Brancheck J, Grant A, Graves K, Cox B. Quantitative Analysis of Supporting Cell Subtype Labeling Among CreER Lines in the Neonatal Mouse Cochlea. J Assoc Res Otolaryngol. 2017;18:227-245 pubmed publisher
    ..cells (SCs) are expressed in multiple SC subtypes, with some lines also showing reporter expression in hair cells (HCs). We hypothesized that altering the tamoxifen dose would modify CreER expression and target subsets of SCs...
  86. Maniaci G, La Cascia C, Picone F, Lipari A, Cannizzaro C, La Barbera D. Predictors of early dropout in treatment for gambling disorder: The role of personality disorders and clinical syndromes. Psychiatry Res. 2017;257:540-545 pubmed publisher
    ..The recruitment included 194 pathological gamblers (PGs) to be compared with 78 healthy controls (HCs). Psychological assessment included the South Oaks Gambling Screen and the Millon Clinical Multiaxial Inventory-III...
  87. Yu Y, Fu X, Ran Q, Yang K, Wen Y, Li H, et al. Globularifolin exerts anticancer effects on glioma U87 cells through inhibition of Akt/mTOR and MEK/ERK signaling pathways in vitro and inhibits tumor growth in vivo. Biochimie. 2017;142:144-151 pubmed publisher
    ..exerted its anticancer activity through induction of apoptosis as evident from the Bid-, and Bax controlled cytochrome c and Omi/HtrA2 release, XIAP suppression, and caspase-9 and 3 signalling cascade...
  88. Castrogiovanni C, Waterschoot B, De Backer O, Dumont P. Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis. Cell Death Differ. 2017;: pubmed publisher the mitochondria, where it interacts with BCL-2 family members to induce membrane permeabilization and cytochrome c release...
  89. Liang S, Vega R, Kong X, Deng W, Wang Q, Ma X, et al. Neurocognitive Graphs of First-Episode Schizophrenia and Major Depression Based on Cognitive Features. Neurosci Bull. 2018;34:312-320 pubmed publisher
    ..first-episode patients with schizophrenia (FES), 125 with MDD, and 237 demographically-matched healthy controls (HCs). The cognitive performance of all participants was evaluated using a battery of neurocognitive tests...
  90. Feng C, Pandey S, Lin C, Shen C, Chang R, Chang T, et al. Cardiac apoptosis induced under high glucose condition involves activation of IGF2R signaling in H9c2 cardiomyoblasts and streptozotocin-induced diabetic rat hearts. Biomed Pharmacother. 2018;97:880-885 pubmed publisher
    ..survival protein p-Akt, p-Bad (Ser 155) and enhanced the expression of apoptosis-inducing proteins cytochrome c and cleaved Caspase-3...
  91. Liuqing W, Liping X, Hui S, Jing L. Elevated IL-37, IL-18 and IL-18BP serum concentrations in patients with primary Sjögren's syndrome. J Investig Med. 2017;65:717-721 pubmed publisher
    ..The serum levels of IL-37 in the patients with pSS were significantly increased compared with the healthy controls (HCs)...
  92. Pidugu V, Yarla N, Bishayee A, Kalle A, Satya A. Novel histone deacetylase 8-selective inhibitor 1,3,4-oxadiazole-alanine hybrid induces apoptosis in breast cancer cells. Apoptosis. 2017;22:1394-1403 pubmed publisher
    ..10b treatment resulted in induction of p21 and inhibition of CDK1 proteins along with cytochrome c release from mitochondria, activation of caspases-3 and -9 and cleavage of poly ADP-ribose polymerase leading ..