cyclin D3

Summary

Gene Symbol: cyclin D3
Description: cyclin D3
Alias: G1/S-specific cyclin-D3, D3-type cyclin
Species: human
Products:     cyclin D3

Top Publications

  1. Inaba T, Matsushime H, Valentine M, Roussel M, Sherr C, Look A. Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. Genomics. 1992;13:565-74 pubmed
    ..gene symbol, CCND1) was assigned to chromosome band 11q13, cyclin D2 (CCND2) to chromosome band 12p13, and cyclin D3 (CCND3) to chromosome band 6p21...
  2. LaBaer J, Garrett M, Stevenson L, Slingerland J, Sandhu C, Chou H, et al. New functional activities for the p21 family of CDK inhibitors. Genes Dev. 1997;11:847-62 pubmed
    ..We suggest that in addition to their roles as inhibitors, the p21 family of proteins, originally identified as inhibitors, may also have roles as adaptor proteins that assemble and program kinase complexes for specific functions. ..
  3. Lin J, Jinno S, Okayama H. Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence. Oncogene. 2001;20:2000-9 pubmed
    ..We have found that the Cdk6-cyclin D3 complex is unique among the D cyclin and kinase combinations in the ability to promote the cell cycle start...
  4. Ebert M, Hernberg S, Fei G, Sokolowski A, Schulz H, Lippert H, et al. Induction and expression of cyclin D3 in human pancreatic cancer. J Cancer Res Clin Oncol. 2001;127:449-54 pubmed
    ..that cyclin D1 and D3 mRNAs are expressed in human pancreatic cancer cell lines, and that the expression of cyclin D3 is enhanced in pancreatic cancer cells by amphiregulin, a member of the epidermal growth factor family...
  5. Ma Y, Yuan J, Huang M, Jove R, Cress W. Regulation of the cyclin D3 promoter by E2F1. J Biol Chem. 2003;278:16770-6 pubmed
    ..In the present work, we present novel evidence that a second G(1) cyclin, cyclin D3, is also potently activated by E2F1...
  6. Bockstaele L, Kooken H, Libert F, Paternot S, Dumont J, De Launoit Y, et al. Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". Mol Cell Biol. 2006;26:5070-85 pubmed
    ..Opposite effects of p27 on cyclin D3-CDK4 activity observed in different systems depended on its stoichiometry in this complex...
  7. Wang W, Zhao L, Tan Y, Ren H, Qi Z. MiR-138 induces cell cycle arrest by targeting cyclin D3 in hepatocellular carcinoma. Carcinogenesis. 2012;33:1113-20 pubmed publisher
    ..We conclude that the frequently downregulated miR-138 can regulate CCND3 and function as a tumor suppressor in HCC. Therefore, miR-138 may serve as a useful therapeutic agent for miRNA-based HCC therapy. ..
  8. Chen J, Saha P, Kornbluth S, Dynlacht B, Dutta A. Cyclin-binding motifs are essential for the function of p21CIP1. Mol Cell Biol. 1996;16:4673-82 pubmed
    ..The Cy sequences may be general motifs used by Cdk inhibitors or substrates to interact with the cyclin in a cyclin-Cdk complex. ..
  9. Wagener R, Aukema S, Schlesner M, Haake A, Burkhardt B, Claviez A, et al. The PCBP1 gene encoding poly(rC) binding protein I is recurrently mutated in Burkitt lymphoma. Genes Chromosomes Cancer. 2015;54:555-64 pubmed publisher
    ..We conclude that PCBP1 mutations are recurrent in Burkitt lymphomas and might contribute, in cooperation with other mutations, to its pathogenesis. ..

More Information

Publications178 found, 100 shown here

  1. Curigliano G, Gomez Pardo P, Meric Bernstam F, Conte P, Lolkema M, Beck J, et al. Ribociclib plus letrozole in early breast cancer: A presurgical, window-of-opportunity study. Breast. 2016;28:191-8 pubmed publisher
    ..The results suggest absence of a drug-drug interaction between ribociclib and letrozole and indicate ribociclib plus letrozole may reduce Ki67 expression in HR+, HER2- BC (NCT01919229). ..
  2. Ross J, Badve S, Wang K, Sheehan C, Boguniewicz A, Otto G, et al. Genomic profiling of advanced-stage, metaplastic breast carcinoma by next-generation sequencing reveals frequent, targetable genomic abnormalities and potential new treatment options. Arch Pathol Lab Med. 2015;139:642-9 pubmed publisher
    ..Our results indicate that genomic profiling using next-generation sequencing can identify clinically meaningful alterations that have the potential to guide targeted treatment decisions in most patients with metastatic MPBC. ..
  3. Pikman Y, Alexe G, Roti G, Conway A, Furman A, Lee E, et al. Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia. Clin Cancer Res. 2017;23:1012-1024 pubmed publisher
    ..b>Cyclin D3 (CCND3) and CDK6 are highly expressed in T-ALL and have been effectively targeted in mutant NOTCH1-driven mouse ..
  4. Peng L, Luo D. Identification of key genes and construction of microRNA-mRNA regulatory networks in bladder smooth muscle cell response to mechanical stimuli using microarray expression profiles and bioinformatics analysis. World J Urol. 2018;36:241-247 pubmed publisher
  5. Martín García D, Navarro A, Valdés Mas R, Clot G, Gutiérrez Abril J, Prieto M, et al. CCND2 and CCND3 hijack immunoglobulin light chain enhancers in cyclin D1-negative mantle cell lymphoma. Blood. 2018;: pubmed publisher
    ..and identified IGK (n=2) and IGL (n=1) enhancer hijackings near CCND3 that were associated with cyclin D3 overexpression...
  6. Garcia Morales P, Hernando E, Carrasco Garcia E, Menéndez Gutierrez M, Saceda M, Martinez Lacaci I. Cyclin D3 is down-regulated by rapamycin in HER-2-overexpressing breast cancer cells. Mol Cancer Ther. 2006;5:2172-81 pubmed
    ..Rapamycin causes down-regulation of cyclin D3 protein, retinoblastoma hypophosphorylation, loss of cyclin-dependent kinase (cdk) 4, cdk6, and cdk2 activity...
  7. Schmitz R, Young R, Ceribelli M, Jhavar S, Xiao W, Zhang M, et al. Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature. 2012;490:116-20 pubmed publisher
    ..In 38% of sporadic BL cases, oncogenic CCND3 mutations produced highly stable cyclin D3 isoforms that drive cell cycle progression...
  8. Korz C, Pscherer A, Benner A, Mertens D, Schaffner C, Leupolt E, et al. Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes. Blood. 2002;99:4554-61 pubmed
    ..In contrast, in MCL the impairment of apoptosis induction seems to play a minor role, whereas most expression data indicate an enhancement of cell proliferation. ..
  9. Vlach J, Hennecke S, Alevizopoulos K, Conti D, Amati B. Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc. EMBO J. 1996;15:6595-604 pubmed
    ..We propose that this activity is mediated by the product of an as yet unknown Myc-Max target gene(s) and represents an essential aspect of Myc's mitogenic and oncogenic functions. ..
  10. Zhang Q, Wang X, Wolgemuth D. Developmentally regulated expression of cyclin D3 and its potential in vivo interacting proteins during murine gametogenesis. Endocrinology. 1999;140:2790-800 pubmed
    To begin to assess the function of the cell cycle regulator cyclin D3 during gametogenesis, the present study examined its expression, interacting partners, and associated kinase activity in the murine testis and ovary...
  11. Decker T, Schneller F, Hipp S, Miething C, Jahn T, Duyster J, et al. Cell cycle progression of chronic lymphocytic leukemia cells is controlled by cyclin D2, cyclin D3, cyclin-dependent kinase (cdk) 4 and the cdk inhibitor p27. Leukemia. 2002;16:327-34 pubmed
    ..b>Cyclin D3 is the principal D-type cyclin which mediates G1 progression in normal B cells, but in B-CLL cells both cyclin ..
  12. Zhang J, Suh Y, Choi Y, Chen P, Davis M, Lee K. Differential Expression of Cell Cycle Regulators During Hyperplastic and Hypertrophic Growth of Broiler Subcutaneous Adipose Tissue. Lipids. 2015;50:965-76 pubmed publisher
    ..This study provides further understanding about broiler fat tissue development which is imperative for effective control of fat deposition. ..
  13. Suo L, Zhou Y, Jia L, Wu H, Zheng J, Lyu Q, et al. Transcriptome profiling of human oocytes experiencing recurrent total fertilization failure. Sci Rep. 2018;8:17890 pubmed publisher
    ..Thus, our work provides a better understanding of transcriptome profiles underlying RTFF, although it based on a limited number of patients. ..
  14. Xiong Y, Menninger J, Beach D, Ward D. Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. Genomics. 1992;13:575-84 pubmed
    ..We now report the molecular cloning of two additional human D-type cyclin genes, CCND2 (cyclin D2) and CCND3 (cyclin D3)...
  15. Mestre Citrinovitz A, Kleff V, Vallejo G, Winterhager E, Saragüeta P. A Suppressive Antagonism Evidences Progesterone and Estrogen Receptor Pathway Interaction with Concomitant Regulation of Hand2, Bmp2 and ERK during Early Decidualization. PLoS ONE. 2015;10:e0124756 pubmed publisher
    ..This novel drug interaction during decidualization could be applied to pathological endometrial cell proliferation processes to improve therapies using steroid hormone receptor targets. ..
  16. Curiel Olmo S, Mondéjar R, Almaraz C, Mollejo M, Cereceda L, Mares R, et al. Splenic diffuse red pulp small B-cell lymphoma displays increased expression of cyclin D3 and recurrent CCND3 mutations. Blood. 2017;129:1042-1045 pubmed publisher
  17. Tamahara T, Ochiai K, Muto A, Kato Y, Sax N, Matsumoto M, et al. The mTOR-Bach2 Cascade Controls Cell Cycle and Class Switch Recombination during B Cell Differentiation. Mol Cell Biol. 2017;37: pubmed publisher
    ..Using expression profiling and chromatin immunoprecipitation assay, the Ccnd3 gene, encoding cyclin D3, was identified as a new direct target of Bach2...
  18. Hirai H, Sherr C. Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1. Mol Cell Biol. 1996;16:6457-67 pubmed
    ..These results raise the possibility that cyclin D-dependent kinases regulate gene expression in an RB independent manner, thereby serving to link other genetic programs to the cell cycle clock. ..
  19. Zhong N, Shi S, Wang H, Wu G, Wang Y, Ma Q, et al. Silencing Aurora-A with siRNA inhibits cell proliferation in human lung adenocarcinoma cells. Int J Oncol. 2016;49:1028-38 pubmed publisher
    ..Therefore, AURKA plays important roles in the proliferation of human lung adenocarcinoma cells, which suggests that AURKA could be a promising tool for lung adenocarcinoma therapy. ..
  20. Doglioni C, Chiarelli C, Macri E, Dei Tos A, Meggiolaro E, Dalla Palma P, et al. Cyclin D3 expression in normal, reactive and neoplastic tissues. J Pathol. 1998;185:159-66 pubmed
    b>Cyclin D3 immunohistochemical expression was investigated in normal, reactive, and neoplastic human embryonal and adult tissues. In the fetus, cyclin D3 was expressed in selected developmental phases of a limited number of cell systems...
  21. Bartkova J, Thullberg M, Slezak P, Jaramillo E, Rubio C, Thomassen L, et al. Aberrant expression of G1-phase cell cycle regulators in flat and exophytic adenomas of the human colon. Gastroenterology. 2001;120:1680-8 pubmed
    ..was undetectable; expression of cyclin D1, CDK4, and pRB correlated with proliferation; and p16, p18, p19, and cyclin D3 were most abundant in quiescent, differentiated cells...
  22. Sterlacci W, Fiegl M, Hilbe W, Jamnig H, Oberaigner W, Schmid T, et al. Deregulation of p27 and cyclin D1/D3 control over mitosis is associated with unfavorable prognosis in non-small cell lung cancer, as determined in 405 operated patients. J Thorac Oncol. 2010;5:1325-36 pubmed publisher
    ..The protein overexpressions of nuclear p27, cyclin D1, cyclin D3, E-cadherin, and EGFR as assessed by immunohistochemistry were all associated with a significant reduction in ..
  23. Yao J, Zuo H, Gao J, Wang M, Wang D, Li X. The effects of IGF-1 on mouse spermatogenesis using an organ culture method. Biochem Biophys Res Commun. 2017;491:840-847 pubmed publisher
    ..These results indicate that IGF-1 plays a critical role in spermatogenesis from SSCs. ..
  24. Durham B, Getta B, Dietrich S, Taylor J, Won H, Bogenberger J, et al. Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations. Blood. 2017;130:1644-1648 pubmed publisher
    ..These data provide further insight into the genetic bases of cHCL and vHCL and mechanisms of RAF inhibitor resistance encountered clinically. ..
  25. Kong L, Meloni A, Nevins J. The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1. Mol Cell. 2006;22:63-71 pubmed
    ..Given previous work implicating E2F in the control of telomerase gene expression, these results thus point to complementary roles for the Rb/E2F pathway in the control of telomere length. ..
  26. Levidou G, Korkolopoulou P, Thymara I, Vassilopoulos I, Saetta A, Gakiopoulou H, et al. Expression and prognostic significance of cyclin D3 in ovarian adenocarcinomas. Int J Gynecol Pathol. 2007;26:410-7 pubmed
    ..However, the clinical significance of the expression of cyclin D3 in ovarian cancer remains undefined...
  27. Lodewick J, Sampaio C, Boxus M, Rinaldi A, Coulonval K, Willems L, et al. Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model. Retrovirology. 2013;10:75 pubmed publisher
    ..p300 and the deacetylases HDAC5/7 and controls phosphorylation of the tumor suppressor pRb by Tax-cyclin D3-CDK4-p21(CIP) complexes...
  28. Zhou X, Xia Y, Li L, Zhang G. MiR-101 inhibits cell growth and tumorigenesis of Helicobacter pylori related gastric cancer by repression of SOCS2. Cancer Biol Ther. 2015;16:160-9 pubmed publisher
    ..Taken together, our results indicated that miR-101 functions as a growth-suppressive miRNA in H. pylori related GC, and that its suppressive effects are mediated mainly by repressing SOCS2 expression. ..
  29. Goda A, Erikson R, Ahn J, Kim B. Induction of G1 Arrest by SB265610 Involves Cyclin D3 Down-regulation and Suppression of CDK2 (Thr160) Phosphorylation. Anticancer Res. 2015;35:3235-43 pubmed
    ..Profiling of G1 regulators revealed cyclin-dependent kinase 2 (CDK2) (Thr160) hypophosphorylation, cyclin D3 gene down-regulation, and p21 post-translational induction...
  30. Alcaide M, Yu S, Bushell K, Fornika D, Nielsen J, Nelson B, et al. Multiplex Droplet Digital PCR Quantification of Recurrent Somatic Mutations in Diffuse Large B-Cell and Follicular Lymphoma. Clin Chem. 2016;62:1238-47 pubmed publisher
    ..targeting 2 additional lymphoma-related hotspots: myeloid differentiation primary response 88 (MYD88; L265P) and cyclin D3 (CCND3; I290R)...
  31. Belso N, Szell M, Pivarcsi A, Kis K, Kormos B, Kenderessy A, et al. Differential expression of D-type cyclins in HaCaT keratinocytes and in psoriasis. J Invest Dermatol. 2008;128:634-42 pubmed
    ..Our data suggest a possible role for D-type cyclins in the excessive basal-cell proliferation and perturbed keratinocyte differentiation in the psoriatic epidermis. ..
  32. Paternot S, Dumont J, Roger P. Differential utilization of cyclin D1 and cyclin D3 in the distinct mitogenic stimulations by growth factors and TSH of human thyrocytes in primary culture. Mol Endocrinol. 2006;20:3279-92 pubmed
    ..does not induce D-type cyclins and p21, it up-regulates p27, and it stimulates the formation and activity of cyclin D3-cyclin-dependent kinase (CDK) 4 complexes...
  33. Xiao F, Zhang W, Chen L, Chen F, Xie H, Xing C, et al. MicroRNA-503 inhibits the G1/S transition by downregulating cyclin D3 and E2F3 in hepatocellular carcinoma. J Transl Med. 2013;11:195 pubmed publisher
    ..Further investigation characterized two cell cycle-related molecules, cyclin D3 and E2F3, as the direct miR-503 targets...
  34. Sebestyén E, Zawisza M, Eyras E. Detection of recurrent alternative splicing switches in tumor samples reveals novel signatures of cancer. Nucleic Acids Res. 2015;43:1345-56 pubmed publisher
    ..Data and software are available at: http://dx.doi.org/10.6084/m9.figshare.1061917 and https://bitbucket.org/regulatorygenomicsupf/iso-ktsp. ..
  35. Geyer J, Subramaniyam S, Jiang Y, Elemento O, Ferry J, de Leval L, et al. Lymphoblastic transformation of follicular lymphoma: a clinicopathologic and molecular analysis of 7 patients. Hum Pathol. 2015;46:260-71 pubmed publisher
    ..After transformation, survival ranged from 1 to 14 months. Four patients died of disease, 2 were in remission after stem cell transplant, and 1 was alive with disease. ..
  36. Li D, Zhao S, Yang Z, Duan C, Guo C, Zhang H, et al. Hmgn5 functions downstream of Hoxa10 to regulate uterine decidualization in mice. Cell Cycle. 2016;15:2792-805 pubmed publisher
    ..In the stromal cells undergoing decidualization, Hmgn5 might act downstream of Hoxa10 to regulate the expression of Cox-2, Vegf and Mmp2. Collectively, Hmgn5 may play an important role during mouse decidualization. ..
  37. Hagglund R, Roizman B. Herpes simplex virus 1 mutant in which the ICP0 HUL-1 E3 ubiquitin ligase site is disrupted stabilizes cdc34 but degrades D-type cyclins and exhibits diminished neurotoxicity. J Virol. 2003;77:13194-202 pubmed
    ..We conclude that the ICP0 HUL-1 domain acts in infected cells to degrade cdc34 and that this function requires the interaction of cdc34 with sequences in exons 2 and 3 but does not involve the HUL-2 RING finger E3 domain. ..
  38. Naderi S, Gutzkow K, Låhne H, Lefdal S, Ryves W, Harwood A, et al. cAMP-induced degradation of cyclin D3 through association with GSK-3beta. J Cell Sci. 2004;117:3769-83 pubmed
    ..We demonstrate that elevation of intracellular levels of cAMP promotes degradation of cyclin D3 in proteasomes, and that this occurs via glycogen synthase kinase-3beta (GSK-3beta)-mediated phosphorylation of ..
  39. Pruneri G, Valentini S, Fabris S, Del Curto B, Laszlo D, Bertolini F, et al. Cyclin D3 immunoreactivity in follicular lymphoma is independent of the t(6;14)(p21.1;q32.3) translocation or cyclin D3 gene amplification and is correlated with histologic grade and Ki-67 labeling index. Int J Cancer. 2004;112:71-7 pubmed
    An abnormal expression of cyclin D3, a key regulator of the cell cycle, has been documented in a variety of human malignancies, and the cyclin D3 gene, mapping to 6p21, may be deregulated in plasma cell myeloma and non-Hodgkin's lymphoma ..
  40. Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H, et al. Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3. FEBS Lett. 2004;573:139-46 pubmed
    b>Cyclin D3 is found to play a crucial role not only in progression through the G1 phase as a regulatory subunit of cyclin-dependent kinase 4 (CDK 4) and CDK 6, but also in many other aspects such as cell cycle, cell differentiation, ..
  41. Kalamvoki M, Roizman B. ICP0 enables and monitors the function of D cyclins in herpes simplex virus 1 infected cells. Proc Natl Acad Sci U S A. 2009;106:14576-80 pubmed publisher
    ..Here, we follow up an observation that ICP0 binds cyclin D3 and that ICP0 mutants unable to bind cyclin D3 are not exported...
  42. Jänicke R, Walker P, Lin X, Porter A. Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis. EMBO J. 1996;15:6969-78 pubmed
    ..Cleaved Rb bound cyclin D3 and inhibited the transcriptional activity of E2F-1, but failed to bind to the regulatory protein MDM2, which ..
  43. Hedberg Y, Ljungberg B, Roos G, Landberg G. Expression of cyclin D1, D3, E, and p27 in human renal cell carcinoma analysed by tissue microarray. Br J Cancer. 2003;88:1417-23 pubmed
    ..In summary, we have shown that G1/S regulatory defects are present in RCC and are associated with clinico-pathological parameters. The pattern of cell cycle regulatory defects also differed between RCC subtypes. ..
  44. Sasaki E, Yatabe Y, Hashimoto M, Yamashita Y, Hasegawa Y, Kojima H, et al. Development-dependent expression of cyclin D3 in precursor T-cell lymphoblastic leukemia/lymphoma. Pathol Int. 2007;57:53-9 pubmed
    In contrast to the clear oncogenic role of cyclins D1 and D2, cyclin D3 is suggested to have a role in the initiation and/or maintenance of differentiation in a lineage-associated manner in addition to its basic role in proliferation...
  45. Schubert K, Stacey D, Arentz G, Clark S, Air T, Hoffmann P, et al. Targeted proteomic analysis of cognitive dysfunction in remitted major depressive disorder: Opportunities of multi-omics approaches towards predictive, preventive, and personalized psychiatry. J Proteomics. 2018;188:63-70 pubmed publisher
    ..mechanisms and candidate biomarkers for cognitive dysfunction in MDD, implicating cell cycle regulation by cyclin D3 (CCND3), regulation of protein processing in the endoplasmatic reticulum by Thioredoxin domain-containing ..
  46. Unek G, Ozmen A, Mendilcioglu I, Simsek M, Korgun E. Immunohistochemical distribution of cell cycle proteins p27, p57, cyclin D3, PCNA and Ki67 in normal and diabetic human placentas. J Mol Histol. 2014;45:21-34 pubmed publisher
    ..Therefore in this study, the immunohistochemical localizations of cell cycle related proteins like PCNA, Ki67, cyclin D3, p27 and p57 in the differentiation, proliferation and apoptosis mechanisms of normal and diabetic placentas ..
  47. Kim J, Kim Y, Ko J. CKbeta8/CCL23 and its isoform CKbeta8-1 induce up-regulation of cyclins via the G(i)/G(o) protein/PLC/PKCdelta/ERK leading to cell-cycle progression. Cytokine. 2010;50:42-9 pubmed publisher
    ..These results indicate that both CKbeta8 and CKbeta8-1 are involved in cell proliferation by modulating the cell cycle regulators. ..
  48. Wang M, Zhang S, Chuang S, Ashton Key M, Ochoa E, Bolli N, et al. Angioimmunoblastic T cell lymphoma: novel molecular insights by mutation profiling. Oncotarget. 2017;8:17763-17770 pubmed publisher
    ..Our findings extend the molecular insights into the multistage development of AITL. ..
  49. Datta N, Williams J, Long M. Differential modulation of G1-S-phase cyclin-dependent kinase 2/cyclin complexes occurs during the acquisition of a polyploid DNA content. Cell Growth Differ. 1998;9:639-50 pubmed
  50. Radulovich N, Pham N, Strumpf D, Leung L, Xie W, Jurisica I, et al. Differential roles of cyclin D1 and D3 in pancreatic ductal adenocarcinoma. Mol Cancer. 2010;9:24 pubmed publisher
    The cyclin D1 (CCND1) and cyclin D3 (CCND3) are frequently co-overexpressed in pancreatic ductal adenocarcinoma (PDAC). Here we examine their differential roles in PDAC...
  51. Zhuang Y, Lu Y, Li D, Sun N, Ju X. Upregulation of AIOLOS induces apoptosis and enhances etoposide chemosensitivity in Jurkat leukemia cells. Oncol Rep. 2015;33:1319-25 pubmed publisher
  52. Bovy N, Blomme B, Frères P, Dederen S, Nivelles O, Lion M, et al. Endothelial exosomes contribute to the antitumor response during breast cancer neoadjuvant chemotherapy via microRNA transfer. Oncotarget. 2015;6:10253-66 pubmed
    ..Taken together, our data are the first to reveal the involvement of the endothelium in the modulation of tumor development via the secretion of circulating miR-503 in response to chemotherapy treatment. ..
  53. Čokić V, Mitrović Ajtić O, Beleslin Čokić B, Marković D, Buač M, Diklić M, et al. Proinflammatory Cytokine IL-6 and JAK-STAT Signaling Pathway in Myeloproliferative Neoplasms. Mediators Inflamm. 2015;2015:453020 pubmed publisher
    ..Therefore, the JAK2V617F mutant allele burden participated in inflammation biomarkers induction and related signaling pathways activation in MPNs. ..
  54. Sansal I, Dupont E, Toru D, Evrard C, Rouget P. NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity. Oncogene. 2000;19:5000-9 pubmed
    ..This interaction reduces the binding of E2F-1 to DNA and its transcriptional activity. Taken together, the data suggest that NPDC-1 could influence cell cycle progression and neural differentiation through its association with E2F-1. ..
  55. Müller Höcker J, Babaryka G, Schmid I, Jung A. Overexpression of cyclin D1, D3, and p21 in an infantile renal carcinoma with Xp11.2 TFE3-gene fusion. Pathol Res Pract. 2008;204:589-97 pubmed publisher
    ..The combined overexpression of p21, cyclin D1, and cyclin D3 was found exclusively in this type but not in other, more common types of renal carcinoma/oncocytoma (n=27)...
  56. Fink J, LeBien T. Novel expression of cyclin-dependent kinase inhibitors in human B-cell precursors. Exp Hematol. 2001;29:490-8 pubmed
    ..RT-PCR analysis showed that cyclin D2, cyclin D3, CDK4, and CDK6 were ubiquitously expressed in normal B-cell development and in the BLIN ALL cell lines...
  57. Takaki T, Echalier A, Brown N, Hunt T, Endicott J, Noble M. The structure of CDK4/cyclin D3 has implications for models of CDK activation. Proc Natl Acad Sci U S A. 2009;106:4171-6 pubmed publisher
    ..pathway of CDK4 activation and substrate selection we have determined the structure of nonphosphorylated CDK4/cyclin D3. This structure of an authentic CDK/cyclin complex shows that cyclin binding may not be sufficient to drive the ..
  58. Seiki T, Naito M, Hishida A, Takagi S, Matsunaga T, Sasakabe T, et al. Association of genetic polymorphisms with erythrocyte traits: Verification of SNPs reported in a previous GWAS in a Japanese population. Gene. 2018;642:172-177 pubmed publisher
    ..In addition, we found a significant interaction between TERT rs2736100 and smoking habit that affected Hb and Ht levels. ..
  59. Meng F, Sun H, Tan X, Li C, Zhou J, Liu W. Negative regulation of cyclin D3 expression by transcription factor c-Ets1 in umbilical cord hematopoietic cells. Acta Pharmacol Sin. 2011;32:1159-64 pubmed publisher
    To investigate the role of transcription factor c-Ets1 in cyclin D3 expression and its effects on the proliferation of umbilical cord hematopoietic cells...
  60. Hiratsuka T, Takei Y, Ohmori R, Imai Y, Ozeki M, Tamaki K, et al. ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway. Oncogene. 2016;35:3227-38 pubmed publisher
    ..using anti-Vpreb antibodies caused aberrant upregulation of c-myc and c-jun and of Ccnd3, which encodes cyclin D3, thereby inducing the growth of pre-B cells...
  61. Kawaguchi Y, Van Sant C, Roizman B. Herpes simplex virus 1 alpha regulatory protein ICP0 interacts with and stabilizes the cell cycle regulator cyclin D3. J Virol. 1997;71:7328-36 pubmed
    ..Our results were as follows. (i) A cDNA in a positive yeast colony was found to encode cyclin D3, a cell cycle regulator of G1 phase...
  62. Wu S, Zhang P, Zeng X, Zhang S, Mo J, Li B, et al. Characterization of the p125 subunit of human DNA polymerase delta and its deletion mutants. Interaction with cyclin-dependent kinase-cyclins. J Biol Chem. 1998;273:9561-9 pubmed
    ..Preliminary experiments showed that phosphorylation of the catalytic subunit of pol delta by cdk2-cyclins had little or no effect on the specific activity of the enzyme. ..
  63. Slot L, Hoogeboom R, Smit L, Wormhoudt T, Biemond B, Oud M, et al. B-Lymphoblastic Lymphomas Evolving from Follicular Lymphomas Co-Express Surrogate Light Chains and Mutated Gamma Heavy Chains. Am J Pathol. 2016;186:3273-3284 pubmed publisher
  64. Bernardin Fried F, Kummalue T, Leijen S, Collector M, Ravid K, Friedman A. AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression. J Biol Chem. 2004;279:15678-87 pubmed
    ..Inhibition of AML1 activity with the CBFbeta-SMMHC or AML1-ETO oncoproteins reduced cyclin D3 RNA expression, and AML1 bound and activated the cyclin D3 promoter...
  65. Wang F, Demir S, Gehringer F, Osswald C, Seyfried F, Enzenmüller S, et al. Tight regulation of FOXO1 is essential for maintenance of B-cell precursor acute lymphoblastic leukemia. Blood. 2018;: pubmed publisher
    ..These results suggest that repression of FOXO1 might be a feasible approach for the treatment of BCP-ALL. ..
  66. Wu J, Lv Q, He J, Zhang H, Mei X, Cui K, et al. MicroRNA-188 suppresses G1/S transition by targeting multiple cyclin/CDK complexes. Cell Commun Signal. 2014;12:66 pubmed publisher
    ..This study demonstrates that miR-188 exerts anticancer effects, via downregulation of multiple G1/S related cyclin/CDKs and Rb/E2F signaling pathway. ..
  67. Arsenijevic T, Degraef C, Dumont J, Roger P, Pirson I. A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95. Biochem J. 2004;378:673-9 pubmed
    Using a yeast interaction screen to search for proteins that interact with cyclin D3 in thyroid gland, we identified the cAMP-dependent AKAP95 (protein kinase A-anchoring protein 95)...
  68. Lu M, Kwan T, Yu C, Chen F, Freedman B, Schafer J, et al. Peroxisome proliferator-activated receptor gamma agonists promote TRAIL-induced apoptosis by reducing survivin levels via cyclin D3 repression and cell cycle arrest. J Biol Chem. 2005;280:6742-51 pubmed
    ..alter the expression of components of the TRAIL signaling pathway, they profoundly reduce protein levels of cyclin D3, but not other D-type cyclins, by decreasing cyclin D3 mRNA levels and by inducing its proteasomal degradation...
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    ..The frequencies and types of alterations differed between and within tumor types and will be informative for drug development strategies. Mol Cancer Ther; 15(7); 1682-90. ©2016 AACR. ..
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    ..The present findings suggest an anti-proliferative role for miR-26a and miR-138 in PCa by blocking the G1/S-phase transition independent of EZH2 but via a concerted inhibition of crucial cell cycle regulators. ..
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    ..at the G2/M transition through enhanced expression of the cell cycle inhibitor p21 and marked down-regulation of cyclin D3 expression...
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    ..effects were linked to decreased CD30 levels, downregulation of CCNA2 (Cyclin A), CCND2 (Cyclin D2) and CCND3 (Cyclin D3) and upregulation of cyclin-dependent kinase inhibitors CDKN2A (p14) and CDKN1A (p21), but not CDKN1B (p27)...
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    ..Here, using human cancer cells and patient-derived xenografts in mice, we show that the cyclin D3-CDK6 kinase phosphorylates and inhibits the catalytic activity of two key enzymes in the glycolytic pathway, 6-..
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    ..This international initiative provides opportunities for developing new treatment modalities to conquer osteosarcoma. ..
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    ..cancer cell cycle progression and growth in vivo as well as the transcription of cell cycle-related protein Cyclin D3. And, the interference of Cyclin D3 expression by transfecting with Cyclin D3 RNAi inhibited the positive role ..
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    ..Cyclin D2 was detectable in 25 out of 31, and cyclin D3 in all B-CLL lymphocytes populations studied...
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    We report seven large B cell lymphoma patients showing the involvement of tumor cells with cyclin D3 (CCND3) expression in bone marrow (BM) at the initial diagnosis...
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    ..The identified conserved complex might be specific for leaf growth in the second dimension, since it is not present in Poaceae (grasses), which also lack the developmental program it controls. ..
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    ..This work improves our understanding of therapeutic resistance in rrDLBCL and has identified novel therapeutic opportunities especially for the high-risk patients with GCB-type rrDLBCL. Clin Cancer Res; 22(9); 2290-300. ©2015 AACR. ..
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    ..This timing suggests that cdk6, and by analogy its homolog cdk4, links growth factor stimulation with the onset of cell cycle progression. ..
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    To assess the diagnostic performance of FGFR3 and Cyclin D3 urinary protein levels in detecting bladder cancer recurrence. Urine of 321 patients in follow-up for bladder cancer and 150 non-neoplastic urine controls was included...
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    ..These findings provide insights into the roles of five miRNAs in growth inhibition and their potential function as cancer therapeutics. ..
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    ..Immunohistochemistry was used to assess p27(Kip1), Ki-67, Skp2, and cyclin D3 expression in 19 cases of HT and in 10 normal thyroids...