cyclin D1

Summary

Gene Symbol: cyclin D1
Description: cyclin D1
Alias: BCL1, D11S287E, PRAD1, U21B31, G1/S-specific cyclin-D1, B-cell CLL/lymphoma 1, B-cell lymphoma 1 protein, BCL-1 oncogene, PRAD1 oncogene
Species: human
Products:     cyclin D1

Top Publications

  1. Liu B, Zhang Y, Jin M, Ni Q, Liang X, Ma X, et al. Association of selected polymorphisms of CCND1, p21, and caspase8 with colorectal cancer risk. Mol Carcinog. 2010;49:75-84 pubmed publisher
    ..25). Our findings suggest that the selected polymorphisms of p21, CCND1, and caspase8 may not contribute to the risk of colorectal cancer. ..
  2. Kanaan Z, Eichenberger M, Young M, Colliver D, Crawford N, Cobbs G, et al. An alternative cyclin-D1 splice site is not linked to inflammatory bowel disease-associated neoplasia. Int J Biol Markers. 2010;25:27-31 pubmed
    ..This creates a higher concentration of CCND1, facilitating easier passage through the G1/S checkpoint, abnormal cell cycle progression, and possibly carcinogenesis...
  3. Tiemann K, Alluin J, Honegger A, Chomchan P, Gaur S, Yun Y, et al. Small interfering RNAs targeting cyclin D1 and cyclin D2 enhance the cytotoxicity of chemotherapeutic agents in mantle cell lymphoma cell lines. Leuk Lymphoma. 2011;52:2148-54 pubmed publisher
    b>Cyclin D1 (CCND1) is a known cell cycle regulator whose overexpression is a hallmark of mantle cell lymphoma (MCL)...
  4. Wu Y, Fu H, Zhang H, Huang H, Chen M, Zhang L, et al. Cyclin D1 (CCND1) G870A polymorphisms and cervical cancer susceptibility: a meta-analysis based on ten case-control studies. Tumour Biol. 2014;35:6913-8 pubmed publisher
    Many studies have evaluated the association between cyclin D1 (CCND1) G870A polymorphism and cervical cancer susceptibility. However, these studies showed inconsistent results...
  5. Shih L, Tsai C, Tsai M, Tsou Y, Chang W, Li F, et al. Association of cyclin D1 genotypes with nasopharyngeal carcinoma risk. Anticancer Res. 2012;32:1093-8 pubmed
    The cell cycle regulator cyclin D1 (CCND1) is a critical regulator of the G1/S phase transition and plays an important part in several tumor types...
  6. Lundgren K, Brown M, Pineda S, Cuzick J, Salter J, Zabaglo L, et al. Effects of cyclin D1 gene amplification and protein expression on time to recurrence in postmenopausal breast cancer patients treated with anastrozole or tamoxifen: a TransATAC study. Breast Cancer Res. 2012;14:R57 pubmed
    ..of CCND1 is observed in a subgroup of breast cancers with poor prognosis, whereas overexpression of the protein cyclin D1 has been linked to both worse and better clinical outcome...
  7. Cheng C, Liu Y, Yu J, Wang H, Ding S, Hsiung C, et al. Prognostic significance of cyclin D1, ?-catenin, and MTA1 in patients with invasive ductal carcinoma of the breast. Ann Surg Oncol. 2012;19:4129-39 pubmed publisher
    ..cancer progression, we performed a candidate gene-based study that assessed expression change of three genes, cyclin D1, ?-catenin, and metastasis-associated protein-1 (MTA1), involving in aggressive phenotypes of cancerous cells, ..
  8. Tsai H, Yeh Y, Chang Y, Yang I, Lin C, Kuo C, et al. Co-existence of cyclin D1 and vascular endothelial growth factor protein expression is a poor prognostic factor for UICC stage I-III colorectal cancer patients after curative resection. J Surg Oncol. 2013;107:148-54 pubmed publisher
    ..Studies have indicated vascular endothelial growth factor (VEGF) is the predominant angiogenic factor. Cyclin D1 (CCND1) induces production of VEGF and is required for migration of blood vessels...
  9. Sameer A, Parray F, Dar M, Nissar S, Banday M, Rasool S, et al. Cyclin D1 G870A polymorphism and risk of colorectal cancer: a case control study. Mol Med Rep. 2013;7:811-5 pubmed publisher
    ..This study suggests that the cyclin D1 polymorphism is associated with an increased risk of CRC in the Kashmiri population. ..

More Information

Publications86

  1. Li M, Dai W, Zhou H. Cyclin D1 G870A polymorphism and risk of nasopharyngeal carcinoma: a meta-analysis. ScientificWorldJournal. 2013;2013:689048 pubmed publisher
    Recently, there have been a number of studies on the association between cyclin D1 G870A polymorphism and nasopharyngeal carcinoma risk. However, the results of previous reports remain controversial and ambiguous...
  2. Lamb R, Lehn S, Rogerson L, Clarke R, Landberg G. Cell cycle regulators cyclin D1 and CDK4/6 have estrogen receptor-dependent divergent functions in breast cancer migration and stem cell-like activity. Cell Cycle. 2013;12:2384-94 pubmed publisher
    b>Cyclin D1 and its binding partners CDK4/6 are essential regulators of cell cycle progression and are implicated in cancer progression...
  3. Wang W, Zhao Y, Yang J, Lin B, Gu H, Cao X, et al. Cyclin D1 polymorphism and oral cancer: a meta-analysis. Mol Biol Rep. 2013;40:87-95 pubmed publisher
    b>Cyclin D1 (CCND1) plays a critical role in the G1 to S-phase cell cycle transition. Data on the association between the CCND1 A870G polymorphism and oral cancer are conflicting...
  4. Shi Y, Tao Y, Jiang Y, Xu Y, Yan B, Chen X, et al. Nuclear epidermal growth factor receptor interacts with transcriptional intermediary factor 2 to activate cyclin D1 gene expression triggered by the oncoprotein latent membrane protein 1. Carcinogenesis. 2012;33:1468-78 pubmed publisher
    ..Our previous study demonstrated that nuclear EGFR could directly bind to the cyclin D1 promoter under the regulation of the oncoprotein latent membrane protein 1 (LMP1), but it also indicated that ..
  5. Saawarn S, Astekar M, Saawarn N, Dhakar N, Gomateshwar Sagari S. Cyclin d1 expression and its correlation with histopathological differentiation in oral squamous cell carcinoma. ScientificWorldJournal. 2012;2012:978327 pubmed publisher
    b>Cyclin D1 regulates the G1 to S transition of cell cycle. Its deregulation or overexpression may lead to disturbance in the normal cell cycle control and tumour formation...
  6. Aquino G, Franco R, Ronconi F, Anniciello A, Russo L, De Chiara A, et al. Peripheral T-cell Lymphoma with Cyclin D1 overexpression: a case report. Diagn Pathol. 2012;7:79 pubmed publisher
    ..We report a case of peripheral T-cell lymphoma not otherwise specified with heterogeneous nuclear cyclin D1 immunohistochemical overexpression, due to gene copy gain, a phenomenon similar to that observed in mantle cell ..
  7. Zhang L, Jiang F, Xu L, Wang J, Bai J, Yin R, et al. The role of cyclin D1 expression and patient's survival in non-small-cell lung cancer: a systematic review with meta-analysis. Clin Lung Cancer. 2012;13:188-95 pubmed publisher
    The role of cell-cycle protein cyclin D1 in lung cancer remains controversial...
  8. Nie J, Liu L, Zheng W, Chen L, Wu X, Xu Y, et al. microRNA-365, down-regulated in colon cancer, inhibits cell cycle progression and promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2. Carcinogenesis. 2012;33:220-5 pubmed publisher
    ..and indicated that the antitumor effects of miR-365 were probably mediated by its targeting and repression of Cyclin D1 and Bcl-2 expression, thus inhibiting cell cycle progression and promoting apoptosis...
  9. Wang J, Wang Q, Cui Y, Liu Z, Zhao W, Wang C, et al. Knockdown of cyclin D1 inhibits proliferation, induces apoptosis, and attenuates the invasive capacity of human glioblastoma cells. J Neurooncol. 2012;106:473-84 pubmed publisher
    Elevated cyclin D1 (CCND1) in human glioblastoma correlates with poor clinical prognosis...
  10. Xu X, Chen S, Chen W, Zheng W, Xia X, Yang H, et al. The impact of cyclin D1 overexpression on the prognosis of ER-positive breast cancers: a meta-analysis. Breast Cancer Res Treat. 2013;139:329-39 pubmed publisher
    b>Cyclin D1 (CCND1), a key regulator of cell cycle progression, is overexpressed in many human cancers, including breast cancer. However, the impact of CCND1 overexpression in these cancers remains unclear and controversial...
  11. Weinhold N, Johnson D, Chubb D, Chen B, Forsti A, Hosking F, et al. The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Nat Genet. 2013;45:522-525 pubmed publisher
    ..870G>A polymorphism (P = 7.96 × 10(-11)). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation. ..
  12. French J, Ghoussaini M, Edwards S, Meyer K, Michailidou K, Ahmed S, et al. Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am J Hum Genet. 2013;92:489-503 pubmed publisher
    ..binding of ELK4 transcription factor and luciferase activity in reporter assays, and may be associated with low cyclin D1 protein levels in tumors. Another candidate variant, rs78540526, lies in the same enhancer element...
  13. Liu J, Liao Q, Zhang Y, Sun S, Zhong C, Liu X. Cyclin D1 G870A polymorphism and lung cancer risk: a meta-analysis. Tumour Biol. 2012;33:1467-76 pubmed publisher
    Many studies have investigated the association between Cyclin D1 (CCND1) G870A polymorphism and lung cancer risk, but the impact of CCND G870A polymorphism on lung cancer is unclear owing to the obvious inconsistence among those studies...
  14. Dekanic A, Dintinjan R, Budisavljević I, Pecanic S, Butorac M, Jonjic N. Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification. Diagn Pathol. 2011;6:108 pubmed publisher
    ..Study results revealed heterogeneity among CRCs, which could have a predictive value by identifying biologically and probably clinically different subsets of tumors with the possibly diverse response to anti-EGFR therapies. ..
  15. Cao W, Feng Z, Cui Z, Zhang C, Sun Z, Mao L, et al. Up-regulation of enhancer of zeste homolog 2 is associated positively with cyclin D1 overexpression and poor clinical outcome in head and neck squamous cell carcinoma. Cancer. 2012;118:2858-71 pubmed publisher
    ..Real-time PCR and immunohistochemistry were used to evaluate EZH2 and cyclin D1 expression in 46 HNSCC samples, and the expression levels also were re-evaluated in 124 independent samples by ..
  16. Casimiro M, Crosariol M, Loro E, Ertel A, Yu Z, Dampier W, et al. ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice. J Clin Invest. 2012;122:833-43 pubmed publisher
    ..CCND1 (which encodes cyclin D1) is overexpressed in human malignancies and has been shown to play a direct role in transcriptional regulation...
  17. Xu Y, Wu H, Ma H, Xu L, Huo Y, Yin L. MicroRNA-503 suppresses proliferation and cell-cycle progression of endometrioid endometrial cancer by negatively regulating cyclin D1. FEBS J. 2013;280:3768-79 pubmed publisher
    ..The expression of a cell cycle-associated oncogene encoding cyclin D1 (CCND1) was inversely correlated with miR-503 expression in EEC tissues and cell lines...
  18. Zhang B, Liu W, Li L, Lu J, Liu M, Sun Y, et al. KAI1/CD82 and cyclin D1 as biomarkers of invasion, metastasis and prognosis of laryngeal squamous cell carcinoma. Int J Clin Exp Pathol. 2013;6:1060-7 pubmed
    This study aimed to investigate the expressions and significance of KAI1/CD82 and cyclin D1 in laryngeal squamous cell carcinoma (LSCC)...
  19. Sabir M, Baig R, Mahjabeen I, Kayani M. Significance of cyclin D1 polymorphisms in patients with head and neck cancer. Int J Biol Markers. 2013;28:49-55 pubmed publisher
    b>Cyclin D1 plays a key role in cell cycle control, particularly in the transition from G1 to S phase, regulated by cyclin-dependent kinases...
  20. Wang Y, Zhu J, Liu Y, Han G. An analysis of cyclin D1, cytokeratin 5/6 and cytokeratin 8/18 expression in breast papillomas and papillary carcinomas. Diagn Pathol. 2013;8:8 pubmed publisher
    To evaluate the expression levels of cyclin D1 in breast papillomas and papillary carcinomas, and to analyze the types of cells that co-express cyclin D1 with cytokeratin 5/6 (CK 5/6) or with cytokeratin 8/18(CK 8/18)...
  21. Scantlebury J, Luo J, Thorstad W, El Mofty S, Lewis J. Cyclin D1-a prognostic marker in oropharyngeal squamous cell carcinoma that is tightly associated with high-risk human papillomavirus status. Hum Pathol. 2013;44:1672-80 pubmed publisher
    ..We analyzed cyclin D1 immunostaining on a tissue microarray of patients with known clinical follow-up and p16 and human papillomavirus ..
  22. Huang S, Cheng S, Chuang W, Chen I, Liao C, Wang H, et al. Cyclin D1 overexpression and poor clinical outcomes in Taiwanese oral cavity squamous cell carcinoma. World J Surg Oncol. 2012;10:40 pubmed publisher
    b>Cyclin D1 gene regulates cell cycle and plays an important role in the tumorigenesis of human cancers...
  23. Chen X, Zhao T, Li L, Xu C, Zhang X, Tse V, et al. CCND1 G870A polymorphism with altered cyclin D1 transcripts expression is associated with the risk of glioma in a Chinese population. DNA Cell Biol. 2012;31:1107-13 pubmed publisher
    ..008, p=0.004, respectively). In conclusion, our data indicate that the CCND1 G870A polymorphism modulated oncogenic cyclin D1b expression in glioma tissues and may be associated with an increased risk of gliomas in Chinese population. ..
  24. Beltran E, Fresquet V, Martinez Useros J, Richter Larrea J, Sagardoy A, Sesma I, et al. A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma. Proc Natl Acad Sci U S A. 2011;108:12461-6 pubmed publisher
    ..This effective combination therapy also might be exploited in other cyclin-D1-expressing tumors. ..
  25. Xiao Ping H, Tie Hua R, Peng L, Qiu Liang W, Guang Yu Y, Jing Hui H, et al. Cyclin D1 overexpression in esophageal cancer from southern China and its clinical significance. Cancer Lett. 2006;231:94-101 pubmed
    Little reports showed cyclin D1 changes in esophageal cancer from southern China...
  26. Sergentanis T, Economopoulos K. Cyclin D1 G870A polymorphism and breast cancer risk: a meta-analysis comprising 9,911 cases and 11,171 controls. Mol Biol Rep. 2011;38:4955-63 pubmed publisher
    b>Cyclin D1 represents a key molecule in the regulation of cell cycle. CCND1 G870A (rs603965) polymorphism has drawn considerable attention as the A allele may generate a variant splice product with possible oncogenic actions...
  27. Lo H, Hsu S, Ali Seyed M, Gunduz M, Xia W, Wei Y, et al. Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell. 2005;7:575-89 pubmed
    ..Our work suggests that the deregulated iNOS/NO pathway may partly contribute to the malignant biology of tumor cells with high levels of nuclear EGFR and STAT3. ..
  28. Cortessis V, Siegmund K, Xue S, Ross R, Yu M. A case-control study of cyclin D1 CCND1 870A-->G polymorphism and bladder cancer. Carcinogenesis. 2003;24:1645-50 pubmed
    Expression of cyclin D1 is believed to lead to progression through the G1-S cell cycle checkpoint, and both experimental and pathological evidence suggest that over-expression of this protein may increase the risk of several cancers, ..
  29. Newman R, Mobascher A, Mangold U, Koike C, Diah S, Schmidt M, et al. Antizyme targets cyclin D1 for degradation. A novel mechanism for cell growth repression. J Biol Chem. 2004;279:41504-11 pubmed
    ..We now show that antizyme induction also leads to degradation of the cell cycle regulatory protein cyclin D1. We demonstrate that antizyme is capable of specific, noncovalent association with cyclin D1 and that this ..
  30. Burnworth B, Popp S, Stark H, Steinkraus V, Brocker E, Hartschuh W, et al. Gain of 11q/cyclin D1 overexpression is an essential early step in skin cancer development and causes abnormal tissue organization and differentiation. Oncogene. 2006;25:4399-412 pubmed
    ..Furthermore, 11q gain correlated with amplification of the cyclin D1 locus (10/14), as determined by fluorescence in situ hybridization, and overexpression of cyclin D1 protein (25/..
  31. Buch S, Zhu B, Davis A, Odom D, Siegfried J, Grandis J, et al. Association of polymorphisms in the cyclin D1 and XPD genes and susceptibility to cancers of the upper aero-digestive tract. Mol Carcinog. 2005;42:222-8 pubmed
    ..b>Cyclin D1 is a key regulatory protein for the transition of cells from the G(1)-S cell cycle phase...
  32. Wang Y, Dean J, Millar E, Tran T, McNeil C, Burd C, et al. Cyclin D1b is aberrantly regulated in response to therapeutic challenge and promotes resistance to estrogen antagonists. Cancer Res. 2008;68:5628-38 pubmed publisher
    b>Cyclin D1 is a key mediator of cell cycle progression that is aberrantly regulated in multiple cancers, especially in breast cancers...
  33. Jain M, Kumar S, Upadhyay R, Lal P, Tiwari A, Ghoshal U, et al. Influence of apoptosis (BCL2, FAS), cell cycle (CCND1) and growth factor (EGF, EGFR) genetic polymorphisms on survival outcome: an exploratory study in squamous cell esophageal cancer. Cancer Biol Ther. 2007;6:1553-8 pubmed
    ..EGF +61AG genotype was associated with improved survival, however +61GG genotype adversely affected the outcome in patients particularly with upper third location of tumor and lower dose (< or =50) of radiotherapy. ..
  34. Saridaki Z, Papadatos Pastos D, Tzardi M, Mavroudis D, Bairaktari E, Arvanity H, et al. BRAF mutations, microsatellite instability status and cyclin D1 expression predict metastatic colorectal patients' outcome. Br J Cancer. 2010;102:1762-8 pubmed publisher
    The significance of BRAF mutations, microsatelite instability (MSI) status and cyclin D1 expression in patients with metastatic colorectal cancer (mCRC) was evaluated...
  35. Zwijsen R, Buckle R, Hijmans E, Loomans C, Bernards R. Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1. Genes Dev. 1998;12:3488-98 pubmed
    ..b>Cyclin D1 is frequently amplified in breast cancer and can activate ER through direct binding...
  36. Probst Hensch N, Sun C, Van Den Berg D, Ceschi M, Koh W, Yu M. The effect of the cyclin D1 (CCND1) A870G polymorphism on colorectal cancer risk is modified by glutathione-S-transferase polymorphisms and isothiocyanate intake in the Singapore Chinese Health Study. Carcinogenesis. 2006;27:2475-82 pubmed
    b>Cyclin D1 (CCND1) regulates cellular decision between proliferation and growth arrest...
  37. Chen R, Bemis L, Amato C, Myint H, Tran H, Birks D, et al. Truncation in CCND1 mRNA alters miR-16-1 regulation in mantle cell lymphoma. Blood. 2008;112:822-9 pubmed publisher
    b>Cyclin D1 (CCND1) is a well-known regulator of cell-cycle progression. It is overexpressed in several types of cancer including breast, lung, squamous, neuroblastoma, and lymphomas...
  38. Walker J, Assoian R. Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression. Cancer Metastasis Rev. 2005;24:383-93 pubmed
    ..receptors controls the activation of the G1 phase cyclin-dependent kinases, largely by regulating levels of cyclin D1 and p27(kip1)...
  39. Mori N, Fujii M, Hinz M, Nakayama K, Yamada Y, Ikeda S, et al. Activation of cyclin D1 and D2 promoters by human T-cell leukemia virus type I tax protein is associated with IL-2-independent growth of T cells. Int J Cancer. 2002;99:378-85 pubmed
    ..Compared to uninfected cells, higher expression levels of cyclin D1 and D2 mRNA were detected in HTLV-I-infected T-cell lines, which were at least in part mediated by the viral ..
  40. Gautschi O, Ratschiller D, Gugger M, Betticher D, Heighway J. Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation. Lung Cancer. 2007;55:1-14 pubmed
    To review the evidence implicating the deregulation of cyclin D1 in the pathogenesis of non-small cell lung cancer (NSCLC), and to discuss the opportunities for targeted clinical intervention...
  41. Agarwal R, Gonzalez Angulo A, Myhre S, Carey M, Lee J, Overgaard J, et al. Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer. Clin Cancer Res. 2009;15:3654-62 pubmed publisher
    ..b>Cyclin D1 overexpression occurred in luminal and normal-like cancers...
  42. Lu C, Dong J, Ma H, Jin G, Hu Z, Peng Y, et al. CCND1 G870A polymorphism contributes to breast cancer susceptibility: a meta-analysis. Breast Cancer Res Treat. 2009;116:571-5 pubmed publisher
    b>Cyclin D1 (CCND1), a key cell cycle regulatory protein that governs the cell cycle progression from G1 to S phase, can promote cell proliferation or induce growth arrest and apoptosis...
  43. Le Marchand L, Seifried A, Lum Jones A, Donlon T, Wilkens L. Association of the cyclin D1 A870G polymorphism with advanced colorectal cancer. JAMA. 2003;290:2843-8 pubmed
    b>Cyclin D1 (CCND1) is a key cell cycle regulatory protein, the overexpression of which is often found in human tumors and is associated with cell proliferation and poor prognosis...
  44. Lehn S, Tobin N, Berglund P, Nilsson K, Sims A, Jirstrom K, et al. Down-regulation of the oncogene cyclin D1 increases migratory capacity in breast cancer and is linked to unfavorable prognostic features. Am J Pathol. 2010;177:2886-97 pubmed publisher
    The oncogene cyclin D1 is highly expressed in many breast cancers and, despite its proliferation-activating properties, it has been linked to a less malignant phenotype...
  45. Millar E, Dean J, McNeil C, O Toole S, Henshall S, Tran T, et al. Cyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcome. Oncogene. 2009;28:1812-20 pubmed publisher
    Aberrant expression of cyclin D1 protein is a common feature of breast cancer. However, the CCND1 gene encodes two gene products, cyclin D1a and cyclin D1b, which have discrete mechanisms of regulation and impact on cell behavior...
  46. Feng Q, Sekula D, Guo Y, Liu X, Black C, Galimberti F, et al. UBE1L causes lung cancer growth suppression by targeting cyclin D1. Mol Cancer Ther. 2008;7:3780-8 pubmed publisher
    ..The UBE1L-ISG15 pathway was proposed previously to target lung carcinogenesis by inhibiting cyclin D1 expression...
  47. Mao Y, Li Z, Lou C, Zhang Y. Expression of phosphorylated Stat5 predicts expression of cyclin D1 and correlates with poor prognosis of colonic adenocarcinoma. Int J Colorectal Dis. 2011;26:29-35 pubmed publisher
    ..to investigate the correlation between phosphorylated Stat5 (p-Stat5) expression and cell cycle regulators (cyclin D1) expression in colonic adenocarcinoma and the relationship between expression of these two proteins and various ..
  48. Holley S, Matthias C, Jahnke V, Fryer A, Strange R, Hoban P. Association of cyclin D1 polymorphism with increased susceptibility to oral squamous cell carcinoma. Oral Oncol. 2005;41:156-60 pubmed
    ..Our data suggests that the CCND1 GG870 genotype is associated with increased susceptibility to OSCC. The involvement of cyclin D1 polymorphism in mechanisms of SCC development may differ in the different sub-sites of the head and neck.
  49. Bergsagel P, Kuehl W, Zhan F, Sawyer J, Barlogie B, Shaughnessy J. Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood. 2005;106:296-303 pubmed
    ..b>Cyclin D1, D2, or D3 expression appears to be increased and/or dysregulated in virtually all MM tumors despite their low ..
  50. Neves A, Mesquita R, Novelli M, Toddai E, De Sousa S. Comparison between immunohistochemical expression of cyclin D1 and p21 and histological malignancy graduation of oral squamous cell carcinomas. Braz Dent J. 2004;15:93-8 pubmed
    The objective of the present study was to correlate the expression of cyclin D1 with the expression of p21 in 28 cases of oral squamous cell carcinoma (OSCC), as well as to compare the expression of both with a histological graduation of ..
  51. Shu X, Moore D, Cai Q, Cheng J, Wen W, Pierce L, et al. Association of cyclin D1 genotype with breast cancer risk and survival. Cancer Epidemiol Biomarkers Prev. 2005;14:91-7 pubmed
    b>Cyclin D1 (CCND1) is a key cell cycle regulatory protein that governs cell cycle progression from the G(1) to S phase...
  52. Comstock C, Augello M, Benito R, Karch J, Tran T, Utama F, et al. Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancer. Clin Cancer Res. 2009;15:5338-49 pubmed publisher
    ..First, relative expression of both cyclin D1 isoforms was determined in prostate adenocarcinomas. Second, relevance of the androgen axis was determined...
  53. Grunhage F, Jungck M, Lamberti C, Berg C, Becker U, Schulte Witte H, et al. Association of familial colorectal cancer with variants in the E-cadherin (CDH1) and cyclin D1 (CCND1) genes. Int J Colorectal Dis. 2008;23:147-54 pubmed
    ..We report a potential association of variants in the CCND1 and CDH1 genes with fCRC using a unique study design with phenotypic extremes. ..
  54. Monteiro E, Varzim G, Pires A, Teixeira M, Lopes C. Cyclin D1 A870G polymorphism and amplification in laryngeal squamous cell carcinoma: implications of tumor localization and tobacco exposure. Cancer Detect Prev. 2004;28:237-43 pubmed
    Altered Cyclin D1 activity, due to gene amplification and/or protein overexpression, is related to the development of several human cancers, including head and neck SCC...
  55. Hedberg Y, Ljungberg B, Roos G, Landberg G. Expression of cyclin D1, D3, E, and p27 in human renal cell carcinoma analysed by tissue microarray. Br J Cancer. 2003;88:1417-23 pubmed
    ..Therefore, we have examined the protein contents of cyclin D1, D3, E, and p27 in 218 RCCs, using tissue microarray and immunohistochemistry...
  56. Serrano M, Hannon G, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature. 1993;366:704-7 pubmed
    ..p16 seems to act in a regulatory feedback circuit with CDK4, D-type cyclins and retinoblastoma protein. ..
  57. Yaylim Eraltan I, Arikan S, Yildiz Y, Cacina C, Ergen H, Tuna G, et al. The influence of cyclin D1 A870G polymorphism on colorectal cancer risk and prognosis in a Turkish population. Anticancer Res. 2010;30:2875-80 pubmed
    b>Cyclin D1, encoded by the gene CCND1, is a regulatory protein in the cell cycle transition from G(1) phase to S phase...
  58. Onay U, Aaltonen K, Briollais L, Knight J, Pabalan N, Kilpivaara O, et al. Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk. BMC Cancer. 2008;8:6 pubmed publisher
    ..Using two independent Caucasian populations, we have shown a stronger combined effect of the two commonly occurring CCND1 and COMT genotypes in the context of breast cancer predisposition. ..
  59. Feng M, Li Z, Aau M, Wong C, Yang X, Yu Q. Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation. Oncogene. 2011;30:2242-51 pubmed publisher
    ..TOB2, which is further elucidated as a candidate tumor suppressor to transcriptionally repress proto-oncogene cyclin D1. Therefore, our study identifies miR-378-TOB2-cyclin D1 as a functional module to mediate the cross talk between ..
  60. Kuroda Y, Sakai A, Tsuyama N, Katayama Y, Munemasa S, Asaoku H, et al. Ectopic cyclin D1 overexpression increases chemosensitivity but not cell proliferation in multiple myeloma. Int J Oncol. 2008;33:1201-13 pubmed
    We established a myeloma cell line (RPMI8226) with cyclin D1 overexpression in which the transfected cyclin D1 gene was stably expressed. D1 transfectants showed down-regulation of cyclin D2...
  61. Bindra R, Vasselli J, Stearman R, Linehan W, Klausner R. VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells. Cancer Res. 2002;62:3014-9 pubmed
    ..Here, we report that cyclin D1 is overexpressed and remains inappropriately high in during contact inhibition in pVHL-deficient cell lines...
  62. Krippl P, Langsenlehner U, Renner W, Yazdani Biuki B, Wolf G, Wascher T, et al. The 870G>A polymorphism of the cyclin D1 gene is not associated with breast cancer. Breast Cancer Res Treat. 2003;82:165-8 pubmed
    A common 870G > A polymorphism in the gene for cyclin D1, CCND1, has been linked to alternative splicing and cancer susceptibility...
  63. Kang S, Kim J, Park N, Song Y, Kang S, Lee H. Cyclin D1 polymorphism and the risk of endometrial cancer. Gynecol Oncol. 2005;97:431-5 pubmed
    ..G870A) in the splice donor region of exon 4 enhances alternate splicing, and produces a longer half-life cyclin D1 (CCND1)...
  64. Park S, Chung C, Kang H, Kim J, Jung G. Up-regulation of cyclin D1 by HBx is mediated by NF-kappaB2/BCL3 complex through kappaB site of cyclin D1 promoter. J Biol Chem. 2006;281:31770-7 pubmed
    b>Cyclin D1 is frequently overexpressed in hepatocellular carcinoma (HCC) exhibiting increased malignant phenotypes. It has also been known that the hepatitis Bx (HBx) protein is strongly associated with HCC development and progression...
  65. Feng Q, Sekula D, Muller R, Freemantle S, Dmitrovsky E. Uncovering residues that regulate cyclin D1 proteasomal degradation. Oncogene. 2007;26:5098-106 pubmed
    b>Cyclin D1 regulates G1 cell-cycle progression and is aberrantly expressed in carcinogenesis. Proteasomal degradation of cyclin D1 was highlighted as a cancer chemopreventive mechanism...
  66. Sathyan K, Nalinakumari K, Abraham T, Kannan S. CCND1 polymorphisms (A870G and C1722G) modulate its protein expression and survival in oral carcinoma. Oral Oncol. 2008;44:689-97 pubmed
    b>Cyclin D1 is an essential regulator of the G1 phase of the cell cycle progression and plays an important role in the transition of the cell from the G1 phase to the S phase of the cell cycle...
  67. Yu Z, Wang C, Wang M, Li Z, Casimiro M, Liu M, et al. A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. J Cell Biol. 2008;182:509-17 pubmed publisher
    ..Herein, levels of the miR-17-5p/miR-20a miRNA cluster were inversely correlated to cyclin D1 abundance in human breast tumors and cell lines...
  68. Zhou X, Zhang Z, Yang X, Chen W, Zhang P. Inhibition of cyclin D1 expression by cyclin D1 shRNAs in human oral squamous cell carcinoma cells is associated with increased cisplatin chemosensitivity. Int J Cancer. 2009;124:483-9 pubmed publisher
    b>Cyclin D1 is a well-known cell cycle regulator. Recently, its pro-survival function has been revealed in several tumors...
  69. Catarino R, Pereira D, Breda E, Coelho A, Matos A, Lopes C, et al. Oncogenic virus-associated neoplasia: a role for cyclin D1 genotypes influencing the age of onset of disease?. Biochem Biophys Res Commun. 2008;370:118-22 pubmed publisher
    b>Cyclin D1 (CCND1) is a key regulatory protein at the G1/S checkpoint of the cell cycle. The purpose of our study was to assess the role of CCND1 genotypes influencing the age of onset of oncogenic virus-associated neoplasia...
  70. Comstock C, Augello M, Schiewer M, Karch J, Burd C, Ertel A, et al. Cyclin D1 is a selective modifier of androgen-dependent signaling and androgen receptor function. J Biol Chem. 2011;286:8117-27 pubmed publisher
    ..kinase-independent mechanisms that modify transcription factor action, and recent in vivo studies showed that cyclin D1 associates with a large number of transcriptional regulators in cells of the retina and breast...
  71. Ito M, Habuchi T, Watanabe J, Higashi S, Nishiyama H, Wang L, et al. Polymorphism within the cyclin D1 gene is associated with an increased risk of carcinoma in situ in patients with superficial bladder cancer. Urology. 2004;64:74-8 pubmed
    ..649). Although CCND1 polymorphism is not able to serve as a prognostic marker for bladder cancer, the CCND1 variant A allele may recessively increase the risk of carcinoma in situ incidence in patients with superficial bladder cancer. ..
  72. Akkiz H, Bayram S, Bekar A, Akgöllü E, Ozdil B. Cyclin D1 G870A polymorphism is associated with an increased risk of hepatocellular carcinoma in the Turkish population: case-control study. Cancer Epidemiol. 2010;34:298-302 pubmed publisher
    A common G to A polymorphism (G870A) in the splice donor region of exon 4 of cyclin D1 (CCND1) gene generates two mRNAs (cyclin D1a and D1b) through an alternative splicing at the site of this polymorphism...
  73. Moreno Bueno G, Rodriguez Perales S, Sánchez Estevez C, Hardisson D, Sarrio D, Prat J, et al. Cyclin D1 gene (CCND1) mutations in endometrial cancer. Oncogene. 2003;22:6115-8 pubmed
    b>Cyclin D1 is frequently overexpressed in human neoplasias by gene rearrangement and amplification, but no mutations in the CCND1 gene have so far been reported...
  74. Brown L, Johnson K, Leung S, Bismar T, Benitez J, Foulkes W, et al. Co-amplification of CCND1 and EMSY is associated with an adverse outcome in ER-positive tamoxifen-treated breast cancers. Breast Cancer Res Treat. 2010;121:347-54 pubmed publisher
    ..In addition, EMSY amplification occurred at a lower frequency in BRCA2 mutation carriers providing evidence to support EMSY amplification as a somatic surrogate for BRCA2 loss in sporadic breast cancer. ..
  75. Chen J, Feilotter H, Pare G, Zhang X, Pemberton J, Garady C, et al. MicroRNA-193b represses cell proliferation and regulates cyclin D1 in melanoma. Am J Pathol. 2010;176:2520-9 pubmed publisher
    ..Eighteen of these down-regulated genes, including cyclin D1 (CCND1), were also identified as putative miR-193b targets by TargetScan...
  76. Zhang J, Li Y, Wang R, Wen D, Sarbia M, Kuang G, et al. Association of cyclin D1 (G870A) polymorphism with susceptibility to esophageal and gastric cardiac carcinoma in a northern Chinese population. Int J Cancer. 2003;105:281-4 pubmed
    Our aim was to investigate the association of cyclin D1 (G870A) single nucleotide polymorphism with susceptibility to esophageal and cardiac carcinoma in a northern Chinese population...
  77. Lévêque C, Marsaud V, Renoir J, Sola B. Alternative cyclin D1 forms a and b have different biological functions in the cell cycle of B lymphocytes. Exp Cell Res. 2007;313:2719-29 pubmed
    b>Cyclin D1 is an important regulator of the early phase of the cell cycle and the transcriptional machinery. It is often deregulated in human tumors of various origins and is considered to be an oncogene...