cyclin A

Summary

Gene Symbol: cyclin A
Description: cyclin A2
Alias: CCN1, CCNA, cyclin-A2, cyclin-A
Species: human
Products:     cyclin A

Top Publications

  1. Saha P, Chen J, Thome K, Lawlis S, Hou Z, Hendricks M, et al. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. Mol Cell Biol. 1998;18:2758-67 pubmed
    ..Rapid elimination of the nuclear pool of this protein after the onset of DNA replication and its association with human Orc1 protein and cyclin-cdks supports its identification as human CDC6/Cdc18 protein. ..
  2. Faivre J, Frank Vaillant M, Poulhe R, Mouly H, Jessus C, Brechot C, et al. Centrosome overduplication, increased ploidy and transformation in cells expressing endoplasmic reticulum-associated cyclin A2. Oncogene. 2002;21:1493-500 pubmed
    b>Cyclin A2 is predominantly, but not exclusively, localized in the nucleus from G1/S transition onwards. It is degraded when cells enter mitosis after nuclear envelope breakdown...
  3. Baldassarre G, Belletti B, Nicoloso M, Schiappacassi M, Vecchione A, Spessotto P, et al. p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion. Cancer Cell. 2005;7:51-63 pubmed
    ..This study provides a functional link between proliferation and invasion of tumor cells based on diverse activities of p27(kip1) in different subcellular compartments. ..
  4. Wheeler L, Lents N, Baldassare J. Cyclin A-CDK activity during G1 phase impairs MCM chromatin loading and inhibits DNA synthesis in mammalian cells. Cell Cycle. 2008;7:2179-88 pubmed
    ..b>Cyclin A-CDK2 and cyclin A-CDK1 phosphorylate nuclear substrates during S and G(2) phases, respectfully...
  5. Townsend K, Mason H, Blackford A, Miller E, Chapman J, Sedgwick G, et al. Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression. J Biol Chem. 2009;284:33939-48 pubmed publisher
    ..We suggest therefore that hMDC1 functionally regulates the normal metaphase-to-anaphase transition by modulating the Cdc20-dependent activation of the APC/C. ..
  6. Rape M, Kirschner M. Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature. 2004;432:588-95 pubmed
    ..The re-accumulation of cyclin A causes the inactivation of APC and entry into S phase, but how cyclin A can accumulate in the presence of active ..
  7. Canela N, Orzáez M, Fucho R, Mateo F, Gutierrez R, Pineda Lucena A, et al. Identification of an hexapeptide that binds to a surface pocket in cyclin A and inhibits the catalytic activity of the complex cyclin-dependent kinase 2-cyclin A. J Biol Chem. 2006;281:35942-53 pubmed
    ..d-amino acid hexapeptide, termed NBI1, that inhibits the kinase activity of the cyclin-dependent kinase 2 (cdk2)-cyclin A complex through selective binding to cyclin A...
  8. Ohtoshi A, Maeda T, Higashi H, Ashizawa S, Hatakeyama M. Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex. Biochem Biophys Res Commun. 2000;268:530-4 pubmed
    ..By using yeast two-hybrid screening, we found that cyclin A, a critical cell cycle regulator in the S and G2/M phases, specifically interacts with p55(CDC)...
  9. Mateo F, Vidal Laliena M, Canela N, Busino L, Martinez Balbas M, Pagano M, et al. Degradation of cyclin A is regulated by acetylation. Oncogene. 2009;28:2654-66 pubmed publisher
    b>Cyclin A accumulates at the onset of S phase, remains high during G(2) and early mitosis and is degraded at prometaphase...

More Information

Publications77

  1. Levkau B, Koyama H, Raines E, Clurman B, Herren B, Orth K, et al. Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade. Mol Cell. 1998;1:553-63 pubmed
    ..of human endothelial cells after growth factor deprivation is associated with rapid and dramatic up-regulation of cyclin A-associated cyclin-dependent kinase 2(cdk2) activity...
  2. Di Fiore B, Pines J. How cyclin A destruction escapes the spindle assembly checkpoint. J Cell Biol. 2010;190:501-9 pubmed publisher
    ..the spindle assembly checkpoint (SAC) to restrict APC/C activity until metaphase, yet early substrates, such as cyclin A, are degraded in the presence of the active checkpoint...
  3. Bailly E, Pines J, Hunter T, Bornens M. Cytoplasmic accumulation of cyclin B1 in human cells: association with a detergent-resistant compartment and with the centrosome. J Cell Sci. 1992;101 ( Pt 3):529-45 pubmed
    ..cyclins with which this p34cdc2 fraction interacts, we carefully examined the subcellular distribution of both cyclin A and B1 in HeLa cells...
  4. Russo A, Jeffrey P, Patten A, Massague J, Pavletich N. Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature. 1996;382:325-31 pubmed
    The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A-cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 angstrom...
  5. Carbonaro Hall D, Williams R, Wu L, Warburton D, Zeichner David M, MacDougall M, et al. G1 expression and multistage dynamics of cyclin A in human osteosarcoma cells. Oncogene. 1993;8:1649-59 pubmed
    b>Cyclin A was initially characterized as a 'mitotic cyclin', believed to function exclusively at the G2-to-M phase transition; however, recent studies have provided compelling evidence that cyclin A additionally functions earlier in the ..
  6. Ko E, Kim Y, Cho E, Han J, Shim Y, Park J, et al. Synergistic effect of Bcl-2 and cyclin A2 on adverse recurrence-free survival in stage I non-small cell lung cancer. Ann Surg Oncol. 2013;20:1005-12 pubmed publisher
    The prognostic significance of cyclin A2 overexpression in non-small cell lung cancer (NSCLC) is controversial...
  7. Ge S, Skaar J, Pagano M. APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation. Cell Cycle. 2009;8:167-71 pubmed
    ..We propose that the degradation of Cdc20 represents a critical control mechanism to ensure inactivation of APC/C(Cdc20) in response to the SAC. ..
  8. Klintman M, Strand C, Ahlin C, Beglerbegovic S, Fjällskog M, Grabau D, et al. The prognostic value of mitotic activity index (MAI), phosphohistone H3 (PPH3), cyclin B1, cyclin A, and Ki67, alone and in combinations, in node-negative premenopausal breast cancer. PLoS ONE. 2013;8:e81902 pubmed publisher
    ..prognostic value of the proliferation factors mitotic activity index (MAI), phosphohistone H3 (PPH3), cyclin B1, cyclin A and Ki67, alone and in combinations...
  9. Castro A, Jaumot M, Verges M, Agell N, Bachs O. Microsomal localization of cyclin A and cdk2 in proliferating rat liver cells. Biochem Biophys Res Commun. 1994;201:1072-8 pubmed
    The expression and intracellular localization of cyclin A and cdk2 have been analyzed in rat liver cells proliferatively activated in vivo by a partial hepatectomy...
  10. Tsang W, Wang L, Chen Z, SANCHEZ I, Dynlacht B. SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression. J Cell Biol. 2007;178:621-33 pubmed
    b>Cyclin A/Cdk2 plays an important role during S and G2/M phases of the eukaryotic cell cycle, but the mechanisms by which it regulates cell cycle events are not fully understood...
  11. Wolthuis R, Clay Farrace L, van Zon W, Yekezare M, Koop L, Ogink J, et al. Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A. Mol Cell. 2008;30:290-302 pubmed publisher
    ..in mitosis with high levels of cyclins A and B, but paradoxically the spindle checkpoint does not stabilize cyclin A. Here, we investigated this paradox and found that Cdc20 is rate limiting for cyclin A destruction...
  12. Schulman B, Lindstrom D, Harlow E. Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. Proc Natl Acad Sci U S A. 1998;95:10453-8 pubmed
    ..We have studied the role of a conserved hydrophobic patch on the surface of cyclin A in substrate recognition by cyclin A-cdk2...
  13. Kabeche L, Compton D. Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation. Nature. 2013;502:110-3 pubmed publisher
    ..The switch to more stable k-MT attachments in metaphase requires the proteasome-dependent destruction of cyclin A in prometaphase...
  14. Bogdanow B, Weisbach H, von Einem J, Straschewski S, Voigt S, Winkler M, et al. Human cytomegalovirus tegument protein pp150 acts as a cyclin A2-CDK-dependent sensor of the host cell cycle and differentiation state. Proc Natl Acad Sci U S A. 2013;110:17510-5 pubmed publisher
    ..The major tegument 150-kDa phosphoprotein (pp150) of HCMV binds to cyclin A2 via a functional RXL/Cy motif resulting in its cyclin A2-dependent phosphorylation...
  15. Gong D, Pomerening J, Myers J, Gustavsson C, Jones J, Hahn A, et al. Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1. Curr Biol. 2007;17:85-91 pubmed
    ..However, knocking down cyclin A2 markedly delayed NEB, and knocking down both cyclins A2 and B1 delayed NEB further...
  16. Brown N, Lowe E, Petri E, Skamnaki V, Antrobus R, Johnson L. Cyclin B and cyclin A confer different substrate recognition properties on CDK2. Cell Cycle. 2007;6:1350-9 pubmed
    ..Cyclin B produces an almost identical activated conformation of CDK2 as that produced by cyclin A. There are differences between cyclin A and cyclin B at the recruitment site, which in cyclin A is used to ..
  17. D Angiolella V, Donato V, Vijayakumar S, Saraf A, Florens L, Washburn M, et al. SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature. 2010;466:138-42 pubmed publisher
    ..We propose that SCF(Cyclin F)-mediated degradation of CP110 is required for the fidelity of mitosis and genome integrity. ..
  18. Huang X, Summers M, Pham V, Lill J, Liu J, Lee G, et al. Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. Mol Cell. 2011;42:511-23 pubmed publisher
    ..The APC(CDH1) substrate cyclin A is critical for the G1/S transition and, paradoxically, accumulates even when APC(CDH1) is active...
  19. Wang S, Hasham M, Isordia Salas I, Tsygankov A, Colman R, Guo Y. Upregulation of Cdc2 and cyclin A during apoptosis of endothelial cells induced by cleaved high-molecular-weight kininogen. Am J Physiol Heart Circ Physiol. 2003;284:H1917-23 pubmed
    ..We report that HKa induced a significant upregulation of Cdc2 and cyclin A in proliferating endothelial cells, concurrent with a marked increase of Cdc2 activity...
  20. Meikrantz W, Schlegel R. Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases. J Biol Chem. 1996;271:10205-9 pubmed
    ..Like CDC2 and CDK2, CDK3 was shown to form a complex with cyclin A in vivo. CDK5 did not bind cyclin A to any detectable extent...
  21. Girard F, Strausfeld U, Fernandez A, Lamb N. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell. 1991;67:1169-79 pubmed
    b>Cyclin A protein is synthesized and localized into the nucleus at the onset of S phase in nontransformed mammalian fibroblasts...
  22. Jackman M, Kubota Y, den Elzen N, Hagting A, Pines J. Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm. Mol Biol Cell. 2002;13:1030-45 pubmed
    ..Immunofluorescence studies have shown that both cyclins are nuclear and that a proportion of cyclin A is localized to sites of DNA replication...
  23. Chen J, Saha P, Kornbluth S, Dynlacht B, Dutta A. Cyclin-binding motifs are essential for the function of p21CIP1. Mol Cell Biol. 1996;16:4673-82 pubmed
    ..The Cy sequences may be general motifs used by Cdk inhibitors or substrates to interact with the cyclin in a cyclin-Cdk complex. ..
  24. Oduro J, Uecker R, Hagemeier C, Wiebusch L. Inhibition of human cytomegalovirus immediate-early gene expression by cyclin A2-dependent kinase activity. J Virol. 2012;86:9369-83 pubmed publisher
    ..This block can be overcome by inhibition of cyclin-dependent kinases (CDKs), suggesting that cyclin A2, the only cyclin with an S/G(2)-specific activity profile, may act as a negative regulator of viral gene ..
  25. Arsic N, Bendris N, Peter M, Begon Pescia C, Rebouissou C, Gadea G, et al. A novel function for Cyclin A2: control of cell invasion via RhoA signaling. J Cell Biol. 2012;196:147-62 pubmed publisher
    b>Cyclin A2 plays a key role in cell cycle regulation. It is essential in embryonic cells and in the hematopoietic lineage yet dispensable in fibroblasts...
  26. Chibazakura T, Kamachi K, Ohara M, Tane S, Yoshikawa H, Roberts J. Cyclin A promotes S-phase entry via interaction with the replication licensing factor Mcm7. Mol Cell Biol. 2011;31:248-55 pubmed publisher
    b>Cyclin A is known to promote S-phase entry in mammals, but its critical targets in this process have not been defined...
  27. Lowe E, Tews I, Cheng K, Brown N, Gul S, Noble M, et al. Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A. Biochemistry. 2002;41:15625-34 pubmed
    ..cell cycle is regulated by the action of the cyclin dependent protein kinase 2 (CDK2) in association with cyclin A. CDK2/cyclin A phosphorylates numerous substrates...
  28. Verges M, Castro A, Jaumot M, Bachs O, Enrich C. Cyclin A is present in the endocytic compartment of rat liver cells and increases during liver regeneration. Biochem Biophys Res Commun. 1997;230:49-53 pubmed
    Recent studies have implicated the cell cycle kinase cdc2 and cyclin A in the inhibition of the fusion of endocytic vesicles in vitro during mitosis...
  29. Izawa D, Pines J. How APC/C-Cdc20 changes its substrate specificity in mitosis. Nat Cell Biol. 2011;13:223-33 pubmed publisher
    ..block the degradation of metaphase substrates (for example, cyclin B1 and securin), but not others (for example, cyclin A). How this is achieved is unclear...
  30. Furuno N, den Elzen N, Pines J. Human cyclin A is required for mitosis until mid prophase. J Cell Biol. 1999;147:295-306 pubmed
    We have used microinjection and time-lapse video microscopy to study the role of cyclin A in mitosis...
  31. Gong D, Ferrell J. The roles of cyclin A2, B1, and B2 in early and late mitotic events. Mol Biol Cell. 2010;21:3149-61 pubmed publisher
    ..Knocking down cyclin A2 resulted in a substantial (∼7 h) delay in chromatin condensation and histone H3 phosphorylation, and ..
  32. Vlach J, Hennecke S, Amati B. Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J. 1997;16:5334-44 pubmed
    ..We propose that cellular p27 must also exist transiently in a cyclin-bound non-inhibitory conformation in vivo. ..
  33. Petersen B, Lukas J, Sørensen C, Bartek J, Helin K. Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. EMBO J. 1999;18:396-410 pubmed
    ..CDC6 interacts specifically with the active Cyclin A/CDK2 complex in vitro and in vivo, but not with Cyclin E or Cyclin B kinase complexes...
  34. Beamish H, de Boer L, Giles N, Stevens F, Oakes V, Gabrielli B. Cyclin A/cdk2 regulates adenomatous polyposis coli-dependent mitotic spindle anchoring. J Biol Chem. 2009;284:29015-23 pubmed publisher
    ..Here we report that the mitotic anchoring and orientation function of APC is regulated by cyclin A/cdk2...
  35. Mrena J, Wiksten J, Kokkola A, Nordling S, Haglund C, Ristimaki A. Prognostic significance of cyclin A in gastric cancer. Int J Cancer. 2006;119:1897-901 pubmed
    High level of cyclin A promotes carcinogenesis, and overexpression of cyclin A has been associated with poor prognosis of cancer patients...
  36. Pagano M, Pepperkok R, Verde F, Ansorge W, Draetta G. Cyclin A is required at two points in the human cell cycle. EMBO J. 1992;11:961-71 pubmed
    Cyclins play a fundamental role in regulating cell cycle events in all eukaryotic cells. The human cyclin A gene was identified as the site of integration of hepatitis B virus in a hepatocarcinoma cell line; in addition, cyclin A is ..
  37. Varadarajan R, Ayeni J, Jin Z, Homola E, Campbell S. Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes. Mol Biol Cell. 2016;27:2051-63 pubmed publisher
    ..These myt1 defects can be suppressed by depletion of Cyclin A activity or ectopic expression of Wee1 (a partially redundant Cdk1 inhibitory kinase) and phenocopied by ..
  38. Wang C, Luo Y, Lu J, Wang Y, Sheng G. Polydatin Induces Apoptosis and Inhibits Growth of Acute Monocytic Leukemia Cells. J Biochem Mol Toxicol. 2016;30:200-5 pubmed publisher
    ..Meanwhile, the protein expression level of Bc1-2, Bax, cyclin A, cyclin B, and cyclin D1, which associated with apoptosis and cell cycle were analyzed by Western blotting...
  39. Gaiddon C, Lokshin M, Gross I, Levasseur D, Taya Y, Loeffler J, et al. Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73. J Biol Chem. 2003;278:27421-31 pubmed
    ..Furthermore, cyclin A/CDK1/2, cyclin B/CDK1/2, and cyclin E/CDK2 complexes can phosphorylate multiple p73 isoforms in vitro at ..
  40. Wang Y, Kojetin D, Burris T. Anti-proliferative actions of a synthetic REV-ERBα/β agonist in breast cancer cells. Biochem Pharmacol. 2015;96:315-22 pubmed publisher
    ..SR9011 appears to pause the cell cycle of the breast cancer cells prior to M phase. Cyclin A (CCNA2) was identified as a direct target gene of REV-ERB suggesting that suppression of expression of this ..
  41. Ye Q, Lei L, Aili A. Identification of potential targets for ovarian cancer treatment by systematic bioinformatics analysis. Eur J Gynaecol Oncol. 2015;36:283-9 pubmed
    ..The significant genes and pathways show potential targets for the treatment of ovarian cancer. ..
  42. Hsu P, Mo F. Matricellular protein CCN1 mediates doxorubicin-induced cardiomyopathy in mice. Oncotarget. 2016;7:36698-36710 pubmed publisher
    ..Matricellular protein CCN1 mediates work-overload-induced cardiac injury. We aimed to assess the role of CCN1 in DOX-associated cardiomyopathy...
  43. Gao T, Han Y, Yu L, Ao S, Li Z, Ji J. CCNA2 is a prognostic biomarker for ER+ breast cancer and tamoxifen resistance. PLoS ONE. 2014;9:e91771 pubmed publisher
    ..Nevertheless, in vivo and in vitro experiments and multi-center randomized controlled clinical trials are still needed before its application in clinical settings. ..
  44. Pevarello P, Brasca M, Orsini P, Traquandi G, Longo A, Nesi M, et al. 3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 2. Lead optimization. J Med Chem. 2005;48:2944-56 pubmed
    Inhibitors of cyclin-dependent kinases (CDK) such as CDK2/cyclin A-E are currently undergoing clinical trials to verify their potential as new anticancer agents...
  45. Sayle K, Bentley J, Boyle F, Calvert A, Cheng Y, Curtin N, et al. Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2. Bioorg Med Chem Lett. 2003;13:3079-82 pubmed
    ..The crystal structure of the 4'-carboxamide derivative, in complex with phospho-Thr160 CDK2/cyclin A, confirmed the expected binding mode of the inhibitor, and revealed an additional interaction between the ..
  46. Fareh M, Almairac F, Turchi L, Burel Vandenbos F, Paquis P, Fontaine D, et al. Cell-based therapy using miR-302-367 expressing cells represses glioblastoma growth. Cell Death Dis. 2017;8:e2713 pubmed publisher
    ..miR-302-367 cell-to-cell transfer resulted in the inhibition of its targets such as CXCR4/SDF1, SHH, cyclin D, cyclin A and E2F1...
  47. Zhu H, Chen C, Xue Y, Tong Q, Li X, Chen X, et al. Asperchalasine A, a Cytochalasan Dimer with an Unprecedented Decacyclic Ring System, from Aspergillus flavipes. Angew Chem Int Ed Engl. 2015;54:13374-8 pubmed publisher
    ..More importantly, 1 induced significant G1-phase cell cycle arrest by selectively inhibiting cyclin A, CDK2 and CDK6 in cancerous, but not normal, cells, highlighting it as a potentially selective cell cycle ..
  48. DU Z, Hu L, Zhao G, Li Y, Ma Z. Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells. Mol Vis. 2015;21:523-31 pubmed
    ..using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetracolium bromide assay, and the protein expression levels of cyclin A and cyclin D1 were determined...
  49. Liu T, Wang Q, Li W, Mao F, Yue S, Liu S, et al. Gcn5 determines the fate of Drosophila germline stem cells through degradation of Cyclin A. FASEB J. 2017;31:2185-2194 pubmed publisher
    ..Results showed that Gcn5 is dispensable for the transcriptional silencing of bam, but interacts with Cyclin A to facilitate proper turnover in GSCs...
  50. Kumazaki M, Shinohara H, Taniguchi K, Takai T, Kuranaga Y, Sugito N, et al. Perturbation of the Warburg effect increases the sensitivity of cancer cells to TRAIL-induced cell death. Exp Cell Res. 2016;347:133-42 pubmed publisher
    ..Also, siR-PTBP1 up-regulated the expression level of CCN1, which contributed to the enhanced sensitivity to TRAIL-induced apoptosis...
  51. Twigg S. Regulation and bioactivity of the CCN family of genes and proteins in obesity and diabetes. J Cell Commun Signal. 2018;12:359-368 pubmed publisher
    ..In contrast, CCN1, CCN2 and possibly CCN3, may have a reparative role in wound healing in diabetes, and CCN2 in islet cell ..
  52. Yun J, Chae H, Choi T, Kim E, Bang Y, Chung J, et al. Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway. J Biol Chem. 2003;278:36966-72 pubmed
    ..Cdk2 phosphorylates two serine residues near the DNA-binding domain of the YA subunit of NF-Y. Cyclin A-cdk2 appears to associate with NF-Y both in vitro and in vivo...
  53. Perbal A. The disastrous boomerang effects of "citation mania". J Cell Commun Signal. 2017;: pubmed publisher
    ..papers in current databases and the recent retraction of manuscripts dealing with the biological properties of the CCN1 protein by Lin et al...
  54. Serrano M, Lin A, McCurrach M, Beach D, Lowe S. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell. 1997;88:593-602 pubmed
    ..Negation of ras-induced senescence may be relevant during multistep tumorigenesis. ..
  55. Mateo F, Vidal Laliena M, Canela N, Zecchin A, Martínez Balbás M, Agell N, et al. The transcriptional co-activator PCAF regulates cdk2 activity. Nucleic Acids Res. 2009;37:7072-84 pubmed publisher
    ..These findings identify a previously unknown mechanism that regulates cdk2 activity. ..
  56. Ruffner H, Jiang W, Craig A, Hunter T, Verma I. BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site. Mol Cell Biol. 1999;19:4843-54 pubmed
    ..S1497 can be phosphorylated in vitro by CDK2-cyclin A or E...
  57. Nakanishi M, Kaneko Y, Matsushime H, Ikeda K. Direct interaction of p21 cyclin-dependent kinase inhibitor with the retinoblastoma tumor suppressor protein. Biochem Biophys Res Commun. 1999;263:35-40 pubmed
    ..These findings suggest that pRb may be dynamically regulated by the relative binding and activities of p21 and Cdks. ..
  58. Lees E, Harlow E. Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase. Mol Cell Biol. 1993;13:1194-201 pubmed
    ..Our approach was to map the regions required on the cyclin A molecule for interaction with cdc2...
  59. Patel R, Hughes C, Fredericks S, Lee C, Rose B, Gao K, et al. Cyclin A expression and its diagnostic value in pleomorphic adenoma and carcinoma expleomorphic adenoma of the parotid gland. Histopathology. 2007;51:21-5 pubmed
    To investigate cyclin A expression in pleomorphic adenoma (PA) and carcinoma expleomorphic adenoma (CXPA) of the parotid gland with a view to assessing its potential value as a diagnostic marker for CXPA...
  60. Rosner M, Hengstschlager M. Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2. J Biol Chem. 2004;279:48707-15 pubmed
  61. Hernando E, Nahle Z, Juan G, Diaz Rodriguez E, Alaminos M, Hemann M, et al. Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature. 2004;430:797-802 pubmed
  62. St Gelais C, Kim S, Ding L, Yount J, Ivanov D, Spearman P, et al. A Putative Cyclin-binding Motif in Human SAMHD1 Contributes to Protein Phosphorylation, Localization, and Stability. J Biol Chem. 2016;291:26332-26342 pubmed
    ..We and others have reported that human SAMHD1 interacts with the cell cycle regulatory proteins cyclin A, CDK1, and CDK2, which mediates phosphorylation of SAMHD1 at threonine 592, a post-translational modification ..
  63. Zhu X, Nguyen H, Halicka H, Traganos F, Koff A. Noncatalytic requirement for cyclin A-cdk2 in p27 turnover. Mol Cell Biol. 2004;24:6058-66 pubmed
    ..In vitro, p27 is phosphorylated by cyclin E- and cyclin A-associated cdk2 as well as by cyclin B1-cdk1...
  64. Marti A, Wirbelauer C, Scheffner M, Krek W. Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation. Nat Cell Biol. 1999;1:14-9 pubmed
  65. Pevarello P, Brasca M, Amici R, Orsini P, Traquandi G, Corti L, et al. 3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding. J Med Chem. 2004;47:3367-80 pubmed
    ..Compounds targeting complexes between cyclin-dependent kinases (CDK) and cyclins, such as CDK2/cyclin A and CDK2/cyclin E, and inhibiting their kinase activity are regarded as promising antitumor agents to complement ..
  66. Hsiao Y, Tsai C, Wu P, Hsu S, Liu H, Huang Y, et al. Cantharidin induces G2/M phase arrest by inhibition of Cdc25c and Cyclin A and triggers apoptosis through reactive oxygen species and the mitochondria‑dependent pathways of A375.S2 human melanoma cells. Int J Oncol. 2014;45:2393-402 pubmed publisher
    ..CTD induced ER stress-associated protein expression such as GRP78, IRE1β, ATF6α and caspase-12. Based on those observations, we suggest that CTD may have potential as a novel anti-cancer agent for the treatment of skin cancer. ..
  67. Du J, Du Q, Zhang Y, Sajdik C, Ruan Y, Tian X, et al. Expression of cell-cycle regulatory proteins BUBR1, MAD2, Aurora A, cyclin A and cyclin E in invasive ductal breast carcinomas. Histol Histopathol. 2011;26:761-8 pubmed publisher
    b>Cyclin A, cyclin E, BUBR1, MAD2 and Aurora A are all cell-cycle regulatory proteins and have been proven to play crucial roles in carcinogenesis...
  68. Kloet S, Whiting J, Gafken P, Ranish J, Wang E. Phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7. Mol Cell Biol. 2012;32:3358-69 pubmed publisher
    ..within TFIID by protein phosphorylation leads to activation of TAF1 HAT activity and stimulation of cyclin D1 and cyclin A gene transcription...