Gene Symbol: CYBA
Description: cytochrome b-245 alpha chain
Alias: p22-PHOX, cytochrome b-245 light chain, cytochrome b light chain, cytochrome b(558) alpha chain, cytochrome b(558) alpha-subunit, cytochrome b, alpha polypeptide, cytochrome b-245, alpha polypeptide, cytochrome b558 subunit alpha, flavocytochrome b-558 alpha polypeptide, neutrophil cytochrome b 22 kDa polypeptide, p22 phagocyte B-cytochrome, p22phox, superoxide-generating NADPH oxidase light chain subunit
Species: human
Products:     CYBA

Top Publications

  1. van der Logt E, Janssen C, Van Hooijdonk Z, Roelofs H, Wobbes T, Nagengast F, et al. No association between genetic polymorphisms in NAD(P)H oxidase p22phox and paraoxonase 1 and colorectal cancer risk. Anticancer Res. 2005;25:1465-70 pubmed
    ..Polymorphic variations in NAD(P)H oxidase p22phox and paraoxonase 1 (PON1) enzyme activities may alter superoxide production or the rate of chemical metabolism, ..
  2. Parkos C, Allen R, Cochrane C, Jesaitis A. Purified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000. J Clin Invest. 1987;80:732-42 pubmed
  3. Kim K, Na J, Kang S, Cho Y, Choi D, Kim C, et al. Impact of NAD(P)H oxidase p22 phox gene polymorphism on vascular aging in Korean centenarian and nonagenarian. Int J Cardiol. 2007;123:18-22 pubmed
    ..These results suggest an association between the p22(phox) C242T polymorphism and vascular aging, which might be mediated by the increase of oxidative stress. ..
  4. Li B, Zhang L, Zhang B, Yin Y, Dai L, Pi Y, et al. Association between NADPH oxidase p22(phox) C242T polymorphism and ischemic cerebrovascular disease: a meta-analysis. PLoS ONE. 2013;8:e56478 pubmed publisher
    ..However, this conclusion should be interpreted with caution due to the small sample size. Larger sample-size studies with homogeneous ICVD patients and well-matched controls are required. ..
  5. Yamamoto A, Kami K, Takeya R, Sumimoto H. Interaction between the SH3 domains and C-terminal proline-rich region in NADPH oxidase organizer 1 (Noxo1). Biochem Biophys Res Commun. 2007;352:560-5 pubmed
    ..These findings suggest that Nox activation involves a conformational change leading to disruption of the bis-SH3-PRR interaction in Noxo1. ..
  6. Murase Y, Yamada Y, Hirashiki A, Ichihara S, Kanda H, Watarai M, et al. Genetic risk and gene-environment interaction in coronary artery spasm in Japanese men and women. Eur Heart J. 2004;25:970-7 pubmed
    ..a significant association with coronary artery spasm of one polymorphism (242C-->T in the NADH/NADPH oxidase p22 phox gene) in men and two polymorphisms (-1171/5A-->6A in the stromelysin-1 gene and -634C-->G in the ..
  7. Block K, Gorin Y, Hoover P, Williams P, Chelmicki T, Clark R, et al. NAD(P)H oxidases regulate HIF-2alpha protein expression. J Biol Chem. 2007;282:8019-26 pubmed
    ..We show that in VHL-deficient cells p22phox, Nox4 protein levels and NADPH-dependent superoxide generation are increased...
  8. Guzik T, West N, Black E, McDonald D, Ratnatunga C, Pillai R, et al. Functional effect of the C242T polymorphism in the NAD(P)H oxidase p22phox gene on vascular superoxide production in atherosclerosis. Circulation. 2000;102:1744-7 pubmed
    ..Immunoblotting, reverse-transcription polymerase chain reaction, and DNA sequencing showed that p22phox protein, mRNA, and 242C/T allelic variants are expressed in human blood vessels...
  9. Niemiec P, Nowak T, Balcerzyk A, Krauze J, Zak I. The CYBA gene A640G polymorphism influences predispositions to coronary artery disease through interactions with cigarette smoking and hypercholesterolemia. Biomarkers. 2011;16:405-12 pubmed publisher
    The CYBA gene encodes the p22phox peptide, an essential subunit of vascular NADPH oxidases. The aim of the study was to analyze potential interactions between CYBA gene A640G polymorphism and traditional risk factors of atherosclerosis...

More Information


  1. Di Castelnuovo A, Soccio M, Iacoviello L, Evangelista V, Consoli A, Vanuzzo D, et al. The C242T polymorphism of the p22phox component of NAD(P)H oxidase and vascular risk. Two case-control studies and a meta-analysis. Thromb Haemost. 2008;99:594-601 pubmed publisher
    ..Vascular NAD(P)H oxidase is comprised of several subunits, one of which, p22phox, is encoded by a gene exhibiting several allelic variants...
  2. Genius J, Grau A, Lichy C. The C242T polymorphism of the NAD(P)H oxidase p22phox subunit is associated with an enhanced risk for cerebrovascular disease at a young age. Cerebrovasc Dis. 2008;26:430-3 pubmed publisher
    ..A functionally relevant C242T polymorphism of the CYBA gene encoding the NAD(P)H oxidase p22(phox) subunit, is supposed to lead to an abnormal reduction in the generation ..
  3. Hodgkinson A, Millward B, Demaine A. Association of the p22phox component of NAD(P)H oxidase with susceptibility to diabetic nephropathy in patients with type 1 diabetes. Diabetes Care. 2003;26:3111-5 pubmed
    ..2% of the uncomplicated patients (P < 0.00003). In conclusion, these results suggest NAD(P)H oxidase together with the polyol pathway may contribute to the pathogenesis of diabetic nephropathy. ..
  4. Sales M, Ferreira M, Leme C, Velloso L, Gallani M, Colombo R, et al. Non-effect of p22-phox -930A/G polymorphism on end-organ damage in Brazilian hypertensive patients. J Hum Hypertens. 2007;21:504-6 pubmed
    ..We recently reported that left ventricular hypertrophy is accompanied by increased myocardial p22-phox expression in aortic-banded rats, suggesting that this protein might be involved in hypertensive cardiac hypertrophy. ..
  5. Castejon A, Bracero J, Hoffmann I, Alfieri A, Cubeddu L. NAD(P)H oxidase p22phox gene C242T polymorphism, nitric oxide production, salt sensitivity and cardiovascular risk factors in Hispanics. J Hum Hypertens. 2006;20:772-9 pubmed
    ..We investigated the prevalence of the NAD(P)H oxidase p22phox gene C242T polymorphism, and its possible association with blood pressure, NO production, salt sensitivity and ..
  6. Wang S, Davis S, Cerhan J, Hartge P, Severson R, Cozen W, et al. Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma. Carcinogenesis. 2006;27:1828-34 pubmed
    ..Thirteen single nucleotide polymorphisms (SNPs) from 10 oxidative stress genes (AKR1A1, AKR1C1, CYBA, GPX, MPO, NOS2A, NOS3, OGG1, PPARG and SOD2) were genotyped in 1172 NHL cases and 982 population-based controls ..
  7. Hsueh Y, Lin P, Chen H, Shiue H, Chung C, Tsai C, et al. Genetic polymorphisms of oxidative and antioxidant enzymes and arsenic-related hypertension. J Toxicol Environ Health A. 2005;68:1471-84 pubmed
    ..These results suggested that the NADPH oxidase, MnSOD, and e-NOS polymorphisms, but not catalase, might play a role in the development of arsenic-related hypertension, especially in subjects with high triglyceride levels. ..
  8. Fan M, Raitakari O, Kahonen M, Juonala M, Hutri Kähönen N, Marniemi J, et al. CYBA C242T gene polymorphism and flow-mediated vasodilation in a population of young adults: the Cardiovascular Risk in Young Finns Study. J Hypertens. 2007;25:1381-7 pubmed
    ..The C242T polymorphism of the CYBA gene that encodes p22phox, a component of NADPH oxidase, has been found to modulate superoxide production...
  9. Niemiec P, Zak I, Emich Widera E, Balcerzyk A, Kopyta I, Nowak T, et al. The C242T polymorphism of the gene encoding cytochrome b-245 alpha is not associated with paediatric ischaemic stroke: family-based and case-control study. Neurol Neurochir Pol. 2010;44:453-8 pubmed
    ..The cytochrome b-245 alpha gene (CYBA) encodes cytochrome b-245 alpha light chain (p22phox peptide), a critical element of NAD(P)H oxidases, the most important source of superoxide anion in the cerebral ..
  10. Kokubo Y, Iwai N, Tago N, Inamoto N, Okayama A, Yamawaki H, et al. Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population--the Suita Study. Circ J. 2005;69:138-42 pubmed
    ..Recently, 3 functional polymorphisms, G(-930)A in CYBA, T481S in CLCNKB, and E65K in KCNMB1, were reported to be associated with blood pressure (BP) status and the aim of ..
  11. Mehranpour P, Wang S, Blanco R, Li W, Song Q, Lassegue B, et al. The C242T CYBA polymorphism as a major determinant of NADPH oxidase activity in patients with cardiovascular disease. Cardiovasc Hematol Agents Med Chem. 2009;7:251-9 pubmed
    Single nucleotide polymorphisms (SNP) in the CYBA gene encoding p22(phox) have been associated with respiratory burst and cardiovascular phenotypes...
  12. Hayaishi Okano R, Yamasaki Y, Kajimoto Y, Sakamoto K, Ohtoshi K, Katakami N, et al. Association of NAD(P)H oxidase p22 phox gene variation with advanced carotid atherosclerosis in Japanese type 2 diabetes. Diabetes Care. 2003;26:458-63 pubmed
    To evaluate the association between the C242T polymorphism of the p22 phox gene, an essential component of NAD(P)H oxidase in the vasculature, with intima-media thickness (IMT) of the carotid artery and risk factors for atherosclerosis in ..
  13. Shimo Nakanishi Y, Hasebe T, Suzuki A, Mochizuki H, Nomiyama T, Tanaka Y, et al. Functional effects of NAD(P)H oxidase p22(phox) C242T mutation in human leukocytes and association with thrombotic cerebral infarction. Atherosclerosis. 2004;175:109-15 pubmed
    ..We conclude that C242T of p22(phox) gene is not involved in thrombotic cerebral infarction but more likely in increased NAD(P)H oxidase activity in phagocytes. ..
  14. Leto T, Adams A, de Mendez I. Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets. Proc Natl Acad Sci U S A. 1994;91:10650-4 pubmed
    ..We propose a model in which the oxidase complex assembles through a mechanism involving SH3 domains of both cytosolic proteins and cognate proline-rich targets in other oxidase components. ..
  15. Ushio Fukai M, Zafari A, Fukui T, Ishizaka N, Griendling K. p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J Biol Chem. 1996;271:23317-21 pubmed
    ..We provide the first evidence that p22(phox) is a critical component of superoxide-generating vascular NADH/NADPH oxidase and suggest a central role for this oxidase system in vascular hypertrophy. ..
  16. Letonja M, Nikolajević Starčević J, Batista D, Osredkar J, Petrovic D. Association of the C242T polymorphism in the NADPH oxidase p22 phox gene with carotid atherosclerosis in Slovenian patients with type 2 diabetes. Mol Biol Rep. 2012;39:10121-30 pubmed publisher
    ..Further studies will show if it can be used as a genetic marker for carotid atherosclerosis in diabetic patients. ..
  17. Fan M, Kahonen M, Rontu R, Lehtinen R, Viik J, Niemi M, et al. The p22phox C242T gene polymorphism is associated with a reduced risk of angiographically verified coronary artery disease in a high-risk Finnish Caucasian population. The Finnish Cardiovascular Study. Am Heart J. 2006;152:538-42 pubmed
    ..The p22phox, a component of the NADPH oxidase, is essential for the activation of this enzyme, and intensive expression of ..
  18. de Boer M, de Klein A, Hossle J, Seger R, Corbeel L, Weening R, et al. Cytochrome b558-negative, autosomal recessive chronic granulomatous disease: two new mutations in the cytochrome b558 light chain of the NADPH oxidase (p22-phox). Am J Hum Genet. 1992;51:1127-35 pubmed
    ..In this patient, a G-->A substitution was found at position 1 of intron 4 in the genomic DNA. Therefore, the absence of exon 4 in the cDNA of this patient is due to a splicing error.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  19. Fang S, Wang L, Jia C. Association of p22phox gene C242T polymorphism with coronary artery disease: a meta-analysis. Thromb Res. 2010;125:e197-201 pubmed publisher
    The C242T polymorphism of p22phox gene (rs4673) has been linked to the reduced coronary artery disease (CAD) risk, but results in the published literatures are controversial...
  20. Nasti S, Spallarossa P, Altieri P, Garibaldi S, Fabbi P, Polito L, et al. C242T polymorphism in CYBA gene (p22phox) and risk of coronary artery disease in a population of Caucasian Italians. Dis Markers. 2006;22:167-73 pubmed
    ..have identified a relationship between progression of atherosclerosis and C242T mutation in CYBA gene coding for p22phox, a subunit of the NADH/NADPH oxidase system...
  21. Takeya R, Ueno N, Kami K, Taura M, Kohjima M, Izaki T, et al. Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. J Biol Chem. 2003;278:25234-46 pubmed
    ..NADPH oxidase (Nox) in phagocytes is gp91phox/Nox2, a membrane-integrated protein that forms a heterodimer with p22phox to constitute flavocytochrome b558...
  22. Khan U, Bevan S, Markus H. NADPH oxidase polymorphisms in cerebral small vessel disease. Cerebrovasc Dis. 2007;24:135-8 pubmed
  23. Moreno M, San José G, Fortuno A, Beloqui O, Redon J, Chaves F, et al. A novel CYBA variant, the -675A/T polymorphism, is associated with essential hypertension. J Hypertens. 2007;25:1620-6 pubmed
    ..We searched for new polymorphisms within the CYBA promoter, the human gene that encodes the p22phox protein, and studied their potential association with essential hypertension...
  24. Edderkaoui M, Nitsche C, Zheng L, Pandol S, Gukovsky I, Gukovskaya A. NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox. J Biol Chem. 2011;286:7779-87 pubmed publisher
    ..Up-regulation of p22(phox) represents a novel pro-survival mechanism through which growth factors and Akt inhibit apoptosis in PaCa cells. ..
  25. Ambasta R, Kumar P, Griendling K, Schmidt H, Busse R, Brandes R. Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. J Biol Chem. 2004;279:45935-41 pubmed
    ..We determined whether a direct interaction of Nox1 and Nox4 with the p22phox subunit of the NADPH oxidase occurs...
  26. Perianayagam M, Liangos O, Kolyada A, Wald R, MacKinnon R, Li L, et al. NADPH oxidase p22phox and catalase gene variants are associated with biomarkers of oxidative stress and adverse outcomes in acute renal failure. J Am Soc Nephrol. 2007;18:255-63 pubmed
    ..polymorphisms in the coding region (C to T substitution at position +242) of the pro-oxidant enzyme NADPH oxidase p22phox subunit gene and in the promoter region (C to T substitution at position -262) of the antioxidant enzyme catalase ..
  27. Schreiber R, Ferreira Sae M, Ronchi J, Pio Magalhães J, Cipolli J, Matos Souza J, et al. The C242T polymorphism of the p22-phox gene (CYBA) is associated with higher left ventricular mass in Brazilian hypertensive patients. BMC Med Genet. 2011;12:114 pubmed publisher
    ..This study investigated the impact of the C242T polymorphism of the p22-phox gene (CYBA) on left ventricular structure in Brazilian hypertensive subjects...
  28. Moreno M, San José G, Orbe J, Paramo J, Beloqui O, Diez J, et al. Preliminary characterisation of the promoter of the human p22(phox) gene: identification of a new polymorphism associated with hypertension. FEBS Lett. 2003;542:27-31 pubmed
    ..Mutagenesis experiments showed that the G allele had higher promoter activity than the A allele. These results suggest that the -930(A/G) polymorphism in the p22(phox) promoter may be a novel genetic marker associated with hypertension. ..
  29. Kuroda J, Kitazono T, Ago T, Ninomiya T, Ooboshi H, Kamouchi M, et al. NAD(P)H oxidase p22phox C242T polymorphism and ischemic stroke in Japan: the Fukuoka Stroke Registry and the Hisayama study. Eur J Neurol. 2007;14:1091-7 pubmed
    The C242T polymorphism of p22phox, a component of NAD(P)H oxidase, may have an impact on cardiovascular diseases; however, the association between this polymorphism and brain infarction is not fully understood...
  30. Lim S, Goh S, Lai Y, Tee W, Koh A, Xu X, et al. Relationship between common functional polymorphisms of the p22phox gene (-930A > G and +242C > T) and nephropathy as a result of Type 2 diabetes in a Chinese population. Diabet Med. 2006;23:1037-41 pubmed
    ..In contrast with previous small studies, our data suggest that these SNPs do not confer significantly increased susceptibility to DN secondary to T2DM in Chinese subjects. ..
  31. Schreiber R, Ferreira Sae M, Tucunduva A, Mill J, Costa F, Krieger J, et al. CYBA C242T polymorphism is associated with obesity and diabetes mellitus in Brazilian hypertensive patients. Diabet Med. 2012;29:e55-61 pubmed publisher
    The CYBA C242T polymorphism has been associated with cardiovascular phenotypes such as hypertension and atherosclerosis, but available data are conflicting...
  32. Bedard K, Attar H, Bonnefont J, Jaquet V, Borel C, Plastre O, et al. Three common polymorphisms in the CYBA gene form a haplotype associated with decreased ROS generation. Hum Mutat. 2009;30:1123-33 pubmed publisher
    ..Several members of the NOX family depend on the p22(phox) subunit, encoded by the CYBA gene...
  33. Zalba G, San José G, Moreno M, Fortuno A, Diez J. NADPH oxidase-mediated oxidative stress: genetic studies of the p22(phox) gene in hypertension. Antioxid Redox Signal. 2005;7:1327-36 pubmed
    ..the promoter and in the coding region of CYBA, the gene that encodes the essential subunit of the NADPH oxidase p22phox, some of which seem to influence significantly the activity of these enzymes in the context of cardiovascular ..
  34. Delles C, Zimmerli L, McGrane D, Koh Tan C, Pathi V, McKay A, et al. Vascular stiffness is related to superoxide generation in the vessel wall. J Hypertens. 2008;26:946-55 pubmed publisher
    ..001) and vascular superoxide production (P = 0.033). CYBA C242T and NOS3 G894T polymorphisms had additive effects on vascular superoxide generation (P = 0...
  35. Ochoa M, Razquin C, Zalba G, Martinez Gonzalez M, Martinez J, Marti A. G allele of the -930A>G polymorphism of the CYBA gene is associated with insulin resistance in obese subjects. J Physiol Biochem. 2008;64:127-33 pubmed
    ..The -930A/G polymorphism of the CYBA gene (that codes p22phox, a major component of the NADPH oxidase) has been associated with human hypertension and with a reduction in ..
  36. He M, Jiang C, Zheng H, Wang F, Yang M, Tan H, et al. [Study on the relationship between the polymorphism of P22phox C242T, vitamin E and coronary heart disease]. Wei Sheng Yan Jiu. 2004;33:443-6 pubmed
    To study the C242T mutation frequency of the cytochrome b4 (P22phox) in Chinese and to further ascertain the relationship between the polymorphism of P22Phphox C242T, vitamin E and coronary heart disease (CHD)...
  37. Kuznetsova T, Gavrilov D, Dudanov I, Makarevich P, Balatskiĭ A, Samokhodskaia L, et al. [Influence of polymorphism's of endothelial nitric oxide synthase gene and polymorphism of NADPH oxidase gene on development of complications of arterial hypertension]. Kardiologiia. 2008;48:27-33 pubmed was to analyze the prevalence of polymorphism Glu298Asp of endothelial nitric oxide synthase gene and C242T p22 phox polymorphism of NADPH oxidase gene in patients with arterial hypertension (AH) and their influence on AH ..
  38. Dinauer M, Pierce E, Bruns G, Curnutte J, Orkin S. Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. J Clin Invest. 1990;86:1729-37 pubmed
    ..In order to search for possible mutations in the cytochrome light chain locus, CYBA, the structure of this gene was characterized...
  39. Schirmer M, Hoffmann M, Kaya E, Tzvetkov M, Brockmoller J. Genetic polymorphisms of NAD(P)H oxidase: variation in subunit expression and enzyme activity. Pharmacogenomics J. 2008;8:297-304 pubmed
    ..Expression of CYBA, NCF4 and RAC2 coding for NAD(P)H oxidase subunits was measured in whole blood cells in 59 study participants by ..
  40. He M, Cheng L, Jiang C, Zeng H, Wang J, Wang F, et al. Associations of polymorphism of P22(phox) C242T, plasma levels of vitamin E, and smoking with coronary heart disease in China. Am Heart J. 2007;153:640.e1-6 pubmed
    ..041). These data provide evidence that P22(phox) genotypes are significantly associated with CHD risk in a Chinese population and suggest potential interactions among smoking, P22(phox) genotypes, and vitamin E in relation to CHD risk. ..
  41. Fricker R, Hesse C, Weiss J, Tayrouz Y, Hoffmann M, Unnebrink K, et al. Endothelial venodilator response in carriers of genetic polymorphisms involved in NO synthesis and degradation. Br J Clin Pharmacol. 2004;58:169-77 pubmed
    Polymorphisms of the NOSIII gene and of the CYBA gene have been associated with a number of pathological conditions such as arterial hypertension, coronary artery disease, and myocardial infarction...
  42. Mata Balaguer T, de la Herran R, Ruiz Rejón C, Ruiz Rejón M, Garrido Ramos M, Ruiz Rejón F. Angiotensin-converting enzyme and p22(phox) polymorphisms and the risk of coronary heart disease in a low-risk Spanish population. Int J Cardiol. 2004;95:145-51 pubmed
  43. Wyche K, Wang S, Griendling K, Dikalov S, Austin H, Rao S, et al. C242T CYBA polymorphism of the NADPH oxidase is associated with reduced respiratory burst in human neutrophils. Hypertension. 2004;43:1246-51 pubmed
    Oxidative stress contributes to the pathogenesis of atherosclerosis. p22phox-based NAD(P)H oxidases exist in the vessel wall, acting as important superoxide-generating systems in the vasculature...
  44. Schneider M, Hilgers K, Huang Y, Delles C, John S, Oehmer S, et al. The C242T p22phox polymorphism and endothelium-dependent vasodilation in subjects with hypercholesterolaemia. Clin Sci (Lond). 2003;105:97-103 pubmed
    ..The C242T variant of the CYBA gene encoding the p22phox subunit of the NAD(P)H oxidase, a major source of superoxide production, has been shown to be associated with ..
  45. Macias Reyes A, Rodriguez Esparragon F, Caballero Hidalgo A, Hernandez Trujillo Y, Medina A, Rodriguez Perez J. Insight into the role of CYBA A640G and C242T gene variants and coronary heart disease risk. A case-control study. Free Radic Res. 2008;42:82-92 pubmed publisher
    ..Higher levels of G allele mRNA compared with A allele mRNA were found. NAD(P)H oxidase p22phox sub-unit expression was evaluated with Western blot...
  46. Teimourian S, Zomorodian E, Badalzadeh M, Pouya A, Kannengiesser C, Mansouri D, et al. Characterization of six novel mutations in CYBA: the gene causing autosomal recessive chronic granulomatous disease. Br J Haematol. 2008;141:848-51 pubmed publisher
    One of the rarest forms of chronic granulomatous disease (CGD) is caused by mutations in CYBA, which encodes the p22-phox subunit of the phagocyte NADPH oxidase, leading to defective intracellular killing...
  47. Fan M, Raitakari O, Kahonen M, Juonala M, Hutri Kähönen N, Porsti I, et al. The association between cigarette smoking and carotid intima-media thickness is influenced by the -930A/G CYBA gene polymorphism: the Cardiovascular Risk in Young Finns Study. Am J Hypertens. 2009;22:281-7 pubmed publisher
    ..We hypothesized that the -930A/G CYBA gene polymorphism in the NADPH oxidase influences the association between cigarette smoking and carotid intima-..
  48. Nowak T, Niemiec P, Zak I. [The p22phox protein and the CYBA gene. Their function and associations with atherosclerosis-related diseases]. Wiad Lek. 2013;66:10-7 pubmed
    ..The p22phox subunit plays an important role in the functioning of these enzymes and is encoded by the CYBA gene (cytochrome b-..
  49. Yamada M, Ariga T, Kawamura N, Ohtsu M, Imajoh Ohmi S, Ohshika E, et al. Genetic studies of three Japanese patients with p22-phox-deficient chronic granulomatous disease: detection of a possible common mutant CYBA allele in Japan and a genotype-phenotype correlation in these patients. Br J Haematol. 2000;108:511-7 pubmed
    ..Mutations in the p22-phox gene (CYBA) locus in 16q24 result in one of the rare autosomal recessive forms of CGD...
  50. Nikitin A, Chistiakov D, Minushkina L, Zateyshchikov D, Nosikov V. Association of the CYBA, PPARGC1A, PPARG3, and PPARD gene variants with coronary artery disease and metabolic risk factors of coronary atherosclerosis in a Russian population. Heart Vessels. 2010;25:229-36 pubmed publisher
    ..In this study, we evaluate whether the PPARGC1A Gly482Ser, PPARG3 (-681)C/G, PPARD +294T/C, and CYBA +242C/T gene variants confer the risk of CAD in a Russian population...
  51. Najafi M, Alipoor B, Shabani M, Amirfarhangi A, Ghasemi H. Association between rs4673 (C/T) and rs13306294 (A/G) haplotypes of NAD(P)H oxidase p22phox gene and severity of stenosis in coronary arteries. Gene. 2012;499:213-7 pubmed publisher
    ..Findings have shown that p22phox subunit is an essential element related to the enzyme activity...
  52. Wu Z, Lou Y, Jin W, Liu Y, Lu L, Chen Q, et al. Relationship of the p22phox (CYBA) gene polymorphism C242T with risk of coronary artery disease: a meta-analysis. PLoS ONE. 2013;8:e70885 pubmed publisher
    Observational and experimental studies have thus far been unable to resolve whether the CYBA C242T polymorphism is associated with coronary artery disease (CAD)...
  53. Katakami N, Kaneto H, Matsuoka T, Takahara M, Imamura K, Ishibashi F, et al. Accumulation of gene polymorphisms related to oxidative stress is associated with myocardial infarction in Japanese type 2 diabetic patients. Atherosclerosis. 2010;212:534-8 pubmed publisher
    ..manganese superoxide dismutase (SOD2) Val16Ala, endothelial nitric oxide synthase (NOS3) G894T, NAD(P)H oxidase p22phox (CYBA) C242T, and myeloperoxidase (MPO) G-463A polymorphisms...
  54. Dutta S, Rittinger K. Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1. PLoS ONE. 2010;5:e10478 pubmed publisher
    ..Taken together, this study provides clear evidence that the assembly of the NOX1 oxidase complex can be regulated through reversible protein-protein interactions. ..
  55. Arca M, Conti B, Montali A, Pignatelli P, Campagna F, Barilla F, et al. C242T polymorphism of NADPH oxidase p22phox and recurrence of cardiovascular events in coronary artery disease. Arterioscler Thromb Vasc Biol. 2008;28:752-7 pubmed publisher
    The common C242T polymorphism in the gene for the p22phox subunit of NADPH oxidase has been reported to be negatively associated with oxidative stress, but whether it confers prognostic information is not yet clear...
  56. Niemiec P, Zak I, Wita K. The 242T variant of the CYBA gene polymorphism increases the risk of coronary artery disease associated with cigarette smoking and hypercholesterolemia. Coron Artery Dis. 2007;18:339-46 pubmed
    ..NAD(P)H oxidases are the main source of superoxides in the vasculature, and the phagocyte oxidase (p22phox) encoded by the CYBA gene is a critical component of NAD(P)H oxidases...
  57. Paclet M, Berthier S, Kuhn L, Garin J, Morel F. Regulation of phagocyte NADPH oxidase activity: identification of two cytochrome b558 activation states. FASEB J. 2007;21:1244-55 pubmed
    ..MRPs induce the switch between the partially and the fully "open" cytochrome b558 conformation. Moreover, their effect was independent of p67-phox. Data point out two potential cytochrome b558 activation states...
  58. San José G, Moreno M, Oliván S, Beloqui O, Fortuno A, Diez J, et al. Functional effect of the p22phox -930A/G polymorphism on p22phox expression and NADPH oxidase activity in hypertension. Hypertension. 2004;44:163-9 pubmed
    ..NADPH oxidase is the main source of superoxide in phagocytic and vascular cells, and the p22phox subunit is involved in NADPH oxidase activation...
  59. Matsunaga Irie S, Maruyama T, Yamamoto Y, Motohashi Y, Hirose H, Shimada A, et al. Relation between development of nephropathy and the p22phox C242T and receptor for advanced glycation end product G1704T gene polymorphisms in type 2 diabetic patients. Diabetes Care. 2004;27:303-7 pubmed
    ..We studied the relation between the genotypes of the NADPH p22phox C242T and RAGE G1704T polymorphisms and the development of diabetic nephropathy in type 2 diabetic patients...
  60. Zafari A, Davidoff M, Austin H, Valppu L, Cotsonis G, LASSEGUE B, et al. The A640G and C242T p22(phox) polymorphisms in patients with coronary artery disease. Antioxid Redox Signal. 2002;4:675-80 pubmed
    ..Our study does not support a functional role for the A640G or C242T polymorphisms either in the severity of CAD or in determining endothelial function in older men. ..
  61. Lee W, Hwang T, Oh G, Kwon S, Choi Y, Park J. Genetic factors associated with endothelial dysfunction affect the early onset of coronary artery disease in Korean males. Vasc Med. 2001;6:103-8 pubmed
    ..artery disease (CAD), endothelial nitric oxide synthase (ecNOS) gene a/b polymorphism and NADH/NADPH oxidase p22 phox gene C242T polymorphism were examined in 305 Korean male CAD patients and 215 healthy male control subjects...
  62. Xaplanteris P, Vlachopoulos C, Baou K, Vassiliadou C, Dima I, Ioakeimidis N, et al. The effect of p22(phox) -930A/G, A640G and C242T polymorphisms of NADPH oxidase on peripheral and central pressures in healthy, normotensive individuals. Hypertens Res. 2010;33:814-8 pubmed publisher
    ..These findings further elucidate the role of this polymorphism in the regulation of blood pressure. In contrast, the A640G and C242T SNPs do not influence peripheral and central pressures in normotensives. ..
  63. Goliasch G, Wiesbauer F, Grafl A, Ponweiser E, Blessberger H, Tentzeris I, et al. The effect of p22-PHOX (CYBA) polymorphisms on premature coronary artery disease (? 40 years of age). Thromb Haemost. 2011;105:529-34 pubmed publisher
    ..In our study, we investigated the effect of polymorphisms in the p22-PHOX (CYBA) gene on CAD in young patients (? 40 years)...
  64. Moreno M, San José G, Fortuno A, Beloqui O, Diez J, Zalba G. The C242T CYBA polymorphism of NADPH oxidase is associated with essential hypertension. J Hypertens. 2006;24:1299-306 pubmed
    ..The C242T polymorphism of CYBA, the human gene that encodes p22phox, has been found to be functionally associated with vascular NADPH oxidase activity in atherosclerotic patients...
  65. Martyn K, Frederick L, von Loehneysen K, Dinauer M, Knaus U. Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell Signal. 2006;18:69-82 pubmed
    ..Nox4 associates with the protein p22phox on internal membranes, where ROS generation occurs...