Gene Symbol: CYB561
Description: cytochrome b561
Alias: CYB561A1, FRRS2, cytochrome b561, cytochrome b-561, cytochrome b561 family, member A1, ferric-chelate reductase 2
Species: human
Products:     CYB561

Top Publications

  1. Bérczi A, Zimányi L. The trans-membrane cytochrome b561 proteins: structural information and biological function. Curr Protein Pept Sci. 2014;15:745-60 pubmed
    b>Cytochrome b561 (CYB561) proteins are ascorbate reducible, trans-membrane proteins consisting of 200-300 amino acids, about half of which are hydrophobic...
  2. Luo Y, Zeng B, Zeng L, Du X, Li B, Huo R, et al. Gut microbiota regulates mouse behaviors through glucocorticoid receptor pathway genes in the hippocampus. Transl Psychiatry. 2018;8:187 pubmed publisher
    ..In addition, six glucocorticoid receptor pathway genes (Slc22a5, Aqp1, Stat5a, Ampd3, Plekhf1, and Cyb561) were upregulated in GF mice, and of these only two (Stat5a and Ampd3) were upregulated in LPS-treated mice, ..
  3. van den Berg M, Almomani R, Biaggioni I, van Faassen M, van der Harst P, Silljé H, et al. Mutations in CYB561 Causing a Novel Orthostatic Hypotension Syndrome. Circ Res. 2018;122:846-854 pubmed publisher
    ..mapping and exome and Sanger sequencing revealed pathogenic homozygous mutations in the gene encoding cytochrome b561 (CYB561); a missense variant c.262G>A, p...
  4. McBride O, Yi H, Srivastava M. The human cytochrome b561 gene (CYB561) is located at 17q11-qter. Genomics. 1994;21:662-3 pubmed
  5. Srivastava M, Gibson K, Pollard H, Fleming P. Human cytochrome b561: a revised hypothesis for conformation in membranes which reconciles sequence and functional information. Biochem J. 1994;303 ( Pt 3):915-21 pubmed
    b>Cytochrome b561 is a major transmembrane protein of catecholamine and neuropeptide secretory vesicles...
  6. Kang M, Kameta A, Shin K, Baluda M, Kim H, Park N. Senescence-associated genes in normal human oral keratinocytes. Exp Cell Res. 2003;287:272-81 pubmed
    ..e., gpr1, apo-D, apo-E, apo-L, mmp-1, mmp-3, cyb561, cyp1b1, and cyp4b1, by reverse transcription-PCR...
  7. Kumar M, Pathak D, Kriplani A, Ammini A, Talwar P, Dada R. Nucleotide variations in mitochondrial DNA and supra-physiological ROS levels in cytogenetically normal cases of premature ovarian insufficiency. Arch Gynecol Obstet. 2010;282:695-705 pubmed publisher
  8. Kauwe J, Bailey M, Ridge P, Perry R, Wadsworth M, Hoyt K, et al. Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation. PLoS Genet. 2014;10:e1004758 pubmed publisher
    ..Robust associations in cognitively normal individuals suggest that these SNPs also influence regulation of these proteins more generally and may therefore be relevant to other diseases. ..
  9. Duong L, Fleming P. Isolation and properties of cytochrome b561 from bovine adrenal chromaffin granules. J Biol Chem. 1982;257:8561-4 pubmed
    b>Cytochrome b561 from bovine adrenal medulla chromaffin granules was purified in octylglucoside by hydrophobic chromatography. The apparent molecular weight was determined to be 30,000 by gel electrophoresis in sodium dodecyl sulfate...

More Information


  1. Srivastava M. Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane. J Biol Chem. 1995;270:22714-20 pubmed
    b>Cytochrome b561 is an electron transfer protein unique to neuroendocrine secretory vesicles. The Southern blot hybridization shows that it is a single copy gene highly conserved throughout phylogeny...
  2. Bashtovyy D, Bérczi A, Asard H, Pali T. Structure prediction for the di-heme cytochrome b561 protein family. Protoplasma. 2003;221:31-40 pubmed
    ..The central 4-helix core represents a transmembrane electron transfer architecture that is highly conserved in eukaryotic species. ..
  3. Vargas J, Herpers B, McKie A, Gledhill S, McDonnell J, van den Heuvel M, et al. Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases. Biochim Biophys Acta. 2003;1651:116-23 pubmed
    ..In this study we show that three members of the b561 family of predicted ferric reductases, namely mouse cytochrome b561 and mouse and fly stromal cell-derived receptor 2 (SDR2), have ferric reductase activity...
  4. Fung M, Nguyen C, Mehtani P, Salem R, Perez B, Thomas B, et al. Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans. Circulation. 2008;117:517-25 pubmed publisher
    ..002), and cytochrome b-561 (CYB561, intron 1, C719G; P<0.001), an electron shuttle for catecholamine synthesis...
  5. Asard H, Barbaro R, Trost P, Bérczi A. Cytochromes b561: ascorbate-mediated trans-membrane electron transport. Antioxid Redox Signal. 2013;19:1026-35 pubmed publisher
    ..A CYB561-core domain is also associated with dopamine ?-monooxygenase redox domains (DOMON) in ubiquitous CYBDOM proteins...
  6. Zhang K, Deacon D, Rao F, Schork A, Fung M, Waalen J, et al. Human heart rate: heritability of resting and stress values in twin pairs, and influence of genetic variation in the adrenergic pathway at a microribonucleic acid (microrna) motif in the 3'-UTR of cytochrome b561 [corrected]. J Am Coll Cardiol. 2014;63:358-68 pubmed publisher
    ..of HR, focusing on a component of the autonomic sympathetic pathway already predictive of outflow responses: cytochrome b561 (CYB561), the electron shuttle in catecholamine vesicle membranes for transmitter biosynthesis...