Gene Symbol: CXCR4
Description: chemokine (C-X-C motif) receptor 4
Alias: CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS, CD184 antigen, LPS-associated protein 3, SDF-1 receptor, fusin, leukocyte-derived seven transmembrane domain receptor, lipopolysaccharide-associated protein 3, neuropeptide Y receptor Y3, neuropeptide Y3 receptor, seven transmembrane helix receptor, seven-transmembrane-segment receptor, spleen, stromal cell-derived factor 1 receptor
Species: human

Top Publications

  1. pmc MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1
    Ariel Bier
    Everard and Mina Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Oncotarget 4:665-76. 2013
  2. doi A review on CXCR4/CXCL12 axis in oncology: no place to hide
    Urszula M Domanska
    Department of Medical Oncology, University Medical Centre Groningen, University of Groningen, The Netherlands
    Eur J Cancer 49:219-30. 2013
  3. doi CXCR4 and cancer
    Bungo Furusato
    Center for Prostate Disease Research, Department of Surgery, Uniformed Service University of the Health Sciences, 1530 E Jefferson Street, Rockville, MD 20852, USA
    Pathol Int 60:497-505. 2010
  4. pmc Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway
    Jaime Imitola
    Center for Neurologic Diseases, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:18117-22. 2004
  5. pmc A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors
    Joshua B Rubin
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:13513-8. 2003
  6. doi The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects
    Kirsten Hattermann
    Department of Anatomy, University of Kiel, Center, Kiel, Germany
    Cancer Res 70:3299-308. 2010
  7. ncbi Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone
    Russell S Taichman
    Department of Periodontics, Prevention, and Geriatrics, and the Center for Biorestoration of Oral Health, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Cancer Res 62:1832-7. 2002
  8. ncbi CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion
    Jolanta Libura
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Blood 100:2597-606. 2002
  9. ncbi MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
    Jurgen Bernhagen
    Department of Biochemistry and Molecular Cell Biology, Institute of Biochemistry, University Hospital Aachen, Rheinisch Westfälische Technische Hochschule RWTH Aachen University, D 52074 Aachen, Germany
    Nat Med 13:587-96. 2007
  10. pmc Detection of inferred CCR5- and CXCR4-using HIV-1 variants and evolutionary intermediates using ultra-deep pyrosequencing
    Evelien M Bunnik
    Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS Pathog 7:e1002106. 2011

Research Grants

Detail Information

Publications357 found, 100 shown here

  1. pmc MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1
    Ariel Bier
    Everard and Mina Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Oncotarget 4:665-76. 2013
    ..Silencing of RTVP-1 decreased the self-renewal of GSCs and the expression of CXCR4 and overexpression of CXCR4 abrogated the inhibitory effect of RTVP-1 silencing on GSC self-renewal...
  2. doi A review on CXCR4/CXCL12 axis in oncology: no place to hide
    Urszula M Domanska
    Department of Medical Oncology, University Medical Centre Groningen, University of Groningen, The Netherlands
    Eur J Cancer 49:219-30. 2013
    ..Important representatives of this system are the chemokine ligand CXCL12 and its receptor chemokine receptor 4 (CXCR4)...
  3. doi CXCR4 and cancer
    Bungo Furusato
    Center for Prostate Disease Research, Department of Surgery, Uniformed Service University of the Health Sciences, 1530 E Jefferson Street, Rockville, MD 20852, USA
    Pathol Int 60:497-505. 2010
    The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors and has been identified to play a crucial role in a number of biological processes, including the trafficking and homeostasis of immune cells ..
  4. pmc Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway
    Jaime Imitola
    Center for Neurologic Diseases, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:18117-22. 2004
    ..NSCs express CXC chemokine receptor 4 (CXCR4), the cognate receptor for SDF-1alpha...
  5. pmc A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors
    Joshua B Rubin
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:13513-8. 2003
    ..Here we show that activation of the Gi protein-coupled receptor CXCR4 is critical for the growth of both malignant neuronal and glial tumors...
  6. doi The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects
    Kirsten Hattermann
    Department of Anatomy, University of Kiel, Center, Kiel, Germany
    Cancer Res 70:3299-308. 2010
    The chemokine CXCL12/stromal cell-derived factor-1 and its receptor CXCR4 play a major role in tumor invasion, proliferation, and metastasis. Recently, CXCR7 was identified as a novel, alternate receptor for CXCL12 and CXCL11/I-TAC...
  7. ncbi Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone
    Russell S Taichman
    Department of Periodontics, Prevention, and Geriatrics, and the Center for Biorestoration of Oral Health, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Cancer Res 62:1832-7. 2002
    ..stromal cell-derived factor-1 (SDF-1 or CXCL12; expressed by osteoblasts and endothelial cells) and its receptor (CXCR4) as key elements in these processes...
  8. ncbi CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion
    Jolanta Libura
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Blood 100:2597-606. 2002
    We hypothesized that the CXC chemokine receptor-4 (CXCR4)-stromal-derived factor-1 (SDF-1) axis may be involved in metastasis of CXCR4(+) tumor cells into the bone marrow and lymph nodes, which secrete the alpha-chemokine SDF-1...
  9. ncbi MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
    Jurgen Bernhagen
    Department of Biochemistry and Molecular Cell Biology, Institute of Biochemistry, University Hospital Aachen, Rheinisch Westfälische Technische Hochschule RWTH Aachen University, D 52074 Aachen, Germany
    Nat Med 13:587-96. 2007
    ..We identify the chemokine receptors CXCR2 and CXCR4 as functional receptors for MIF...
  10. pmc Detection of inferred CCR5- and CXCR4-using HIV-1 variants and evolutionary intermediates using ultra-deep pyrosequencing
    Evelien M Bunnik
    Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS Pathog 7:e1002106. 2011
    The emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants is associated with accelerated disease progression...
  11. ncbi Structural basis for coreceptor selectivity by the HIV type 1 V3 loop
    Timothy Cardozo
    Department of Pharmacology and New York University School of Medicine, New York, NY 10016, USA
    AIDS Res Hum Retroviruses 23:415-26. 2007
    ..The CXCR4 and CCR5 chemokine receptors are used by "X4-tropic" and "R5-tropic" viruses, respectively...
  12. ncbi HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    Y Feng
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, MD 20892, USA
    Science 272:872-7. 1996
    ..This protein, designated "fusin," is a putative G protein-coupled receptor with seven transmembrane segments...
  13. pmc LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection
    Paul J Vorster
    Department of Molecular and Microbiology, George Mason University, Manassas, Virginia 20110, USA
    J Biol Chem 286:12554-64. 2011
    ..of the Rack-PAK-LIMK pathway, and that knockdown of LIMK through siRNA decreases filamentous actin, increases CXCR4 trafficking, and diminishes viral DNA synthesis...
  14. ncbi Involvement of SDF-1alpha/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Int J Cancer 122:91-9. 2008
    ..The aim of this study was to determine whether the stromal cell-derived factor-1alpha (SDF-1alpha)/CXCR4 axis is involved in the interaction of EOC cells with HPMCs in peritoneal metastasis...
  15. pmc Coreceptor tropism in human immunodeficiency virus type 1 subtype D: high prevalence of CXCR4 tropism and heterogeneous composition of viral populations
    Wei Huang
    Monogram Biosciences, 345 Oyster Point Blvd, South San Francisco, CA 94080, USA
    J Virol 81:7885-93. 2007
    In human immunodeficiency virus type 1 (HIV-1) subtype B, CXCR4 coreceptor use ranges from approximately 20% in early infection to approximately 50% in advanced disease. Coreceptor use by non-subtype B HIV is less well characterized...
  16. pmc SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial-mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway
    Xuqi Li
    Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi an Jiaotong University, Shaanxi, China
    Cancer Lett 322:169-76. 2012
    In our previous study, we found that blockade of SDF-1/CXCR4 signaling inhibits pancreatic cancer cell migration and invasion in vitro...
  17. pmc Dendritic cells preferentially transfer CXCR4-using human immunodeficiency virus type 1 variants to CD4+ T lymphocytes in trans
    Thijs van Montfort
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, Academic Medical Center of the University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Virol 82:7886-96. 2008 cell entry in the acute phase of infection, while later in disease progression the virus switches to the CXCR4 coreceptor in approximately 50% of patients...
  18. doi Coreceptors and HIV-1 pathogenesis
    Paul R Gorry
    Center for Virology, Burnet Institute, Melbourne, Victoria, Australia
    Curr HIV/AIDS Rep 8:45-53. 2011
    The major HIV-1 coreceptors, CCR5 and CXCR4, mediate virus entry into CD4+ cells and are therefore a critical component of the HIV-1 life cycle...
  19. pmc CXCR7/CXCR4 heterodimer constitutively recruits beta-arrestin to enhance cell migration
    Fabien M Décaillot
    Laboratory of Molecular Biology and Biochemistry, Rockefeller University, New York, New York 10065, USA
    J Biol Chem 286:32188-97. 2011
    ..In this study, we have attempted to identify the functional significance of the heteromeric complex between CXCR4 and CXCR7 chemokine receptors...
  20. pmc Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma
    Yazan Alsayed
    University of Pittsburgh Cancer Institute, Division of Hematology Oncology, Department of Internal Medicine, University of Pittsburgh, PA, USA
    Blood 109:2708-17. 2007
    ..In this study, we sought to determine the effect of the chemokine SDF-1 (CXCL12) and its receptor CXCR4 on the migration and homing of MM cells...
  21. pmc Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5
    C B Davis
    Division of Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, NYU Medical Center 10016, USA
    J Exp Med 186:1793-8. 1997
    Infection with HIV-1 requires expression of CD4 and the chemokine receptors CXCR4 or CCR5 at the target cell surface...
  22. ncbi The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection
    F Cocchi
    Institute of Human Virology, University of Maryland Biotechnology Institute and School of Medicine, Baltimore, Maryland 21201, USA
    Nat Med 2:1244-7. 1996
    ..Consistent with this discrepancy, two distinct chemokine receptors, namely, CXCR4 (ref. 7) and CCR5 (ref...
  23. pmc Differential estrogen-regulation of CXCL12 chemokine receptors, CXCR4 and CXCR7, contributes to the growth effect of estrogens in breast cancer cells
    Antoine Boudot
    UMR CNRS 6026, Molecular and Cellular Interactions, IRSET, University of Rennes 1, IFR 140, Rennes, France
    PLoS ONE 6:e20898. 2011
    b>CXCR4 and CXCR7 are the two receptors for the chemokine CXCL12, a key mediator of the growth effect of estrogens (E2) in estrogen receptor (ER)-positive breast cancers...
  24. ncbi Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis
    Merav Darash-Yahana
    Goldyne Savad Institute of Gene Therapy, HBRC, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    FASEB J 18:1240-2. 2004
    ..We found that high expression levels of the chemokine receptor CXCR4 correlated with the presence of metastatic disease in prostate cancer patients...
  25. pmc CoRSeqV3-C: a novel HIV-1 subtype C specific V3 sequence based coreceptor usage prediction algorithm
    Kieran Cashin
    Center for Virology, Burnet Institute, 85 Commercial Rd, Melbourne 3004VIC, Australia
    Retrovirology 10:24. 2013
    ..In this study, we elucidated the V3 sequence determinants of C-HIV coreceptor usage, and used this knowledge to develop and validate a novel, user friendly, and highly sensitive C-HIV specific coreceptor usage prediction algorithm...
  26. pmc CXCR4/SDF-1 axis is involved in lymph node metastasis of gastric carcinoma
    Bao Cheng Zhao
    Department of General Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
    World J Gastroenterol 17:2389-96. 2011
    To investigate the role of CXC chemokine receptor-4 (CXCR4) and stromal cell-derived factor-1 (SDF-1) in lymph node metastasis of gastric carcinoma.
  27. ncbi CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells
    Tanja N Hartmann
    Department of Medicine, Division of Hematology Oncology, Freiburg University Hospital, Hugstetterstr 55, D 79106 Freiburg, Germany
    Oncogene 24:4462-71. 2005
    ..SCLC cells express high levels of functional CXCR4 receptors for the chemokine stromal-cell-derived factor-1 (SDF-1/CXCL12)...
  28. pmc The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice
    Tania N Petruzziello-Pellegrini
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 122:759-76. 2012
    ..Gene expression profiling of human microvascular endothelium treated with Stx implicated a role for activation of CXCR4 and CXCR7 by their shared cognate chemokine ligand (stromal cell-derived factor-1 [SDF-1]) in Stx-mediated ..
  29. pmc HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells
    Christoph C Carter
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Host Microbe 9:223-34. 2011
    ..Furthermore, we establish that the capacity to use the chemokine receptor CXCR4 for entry determines whether a virus will enter multipotent versus differentiated progenitor cells...
  30. pmc Structural basis of the interaction between chemokine stromal cell-derived factor-1/CXCL12 and its G-protein-coupled receptor CXCR4
    Yutaka Kofuku
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Japan
    J Biol Chem 284:35240-50. 2009
    The chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) and its G-protein-coupled receptor (GPCR) CXCR4 play fundamental roles in many physiological processes, and CXCR4 is a drug target for various diseases such as cancer metastasis ..
  31. doi Stromal-derived factor-1/CXCR4 signaling: indispensable role in homing and engraftment of hematopoietic stem cells in bone marrow
    Menka Sharma
    Stem Cell and Gene Therapy Research Group, Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Defense Research and Development Organization, New Delhi, India
    Stem Cells Dev 20:933-46. 2011
    ..Recent studies have highlighted the pivotal role of unique stromal-derived factor-1 (SDF-1)/CXCR4 signaling in the regulation of HSPC homing and subsequent engraftment...
  32. doi Moesin is required for HIV-1-induced CD4-CXCR4 interaction, F-actin redistribution, membrane fusion and viral infection in lymphocytes
    Marta Barrero-Villar
    Servicio de Inmunologia, Hospital Universitario de la Princesa, 28006 Madrid, Spain
    J Cell Sci 122:103-13. 2009
    ..regulates the initial attachment of viral particles to target cells through its association with CD4 and either CXCR4 or CCR5...
  33. pmc HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3
    Jennifer Van Grol
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 5:e11733. 2010
    ..Neutralization of the upstream receptors VEGFR, beta-integrin or CXCR4, as well as of HIV-1 Tat or IL-10 restored autophagy in macrophage/monocytic cells exposed to HIV-1-infected cells...
  34. ncbi CXCR4 nuclear localization follows binding of its ligand SDF-1 and occurs in metastatic but not primary renal cell carcinoma
    Linhui Wang
    The Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, PR China
    Oncol Rep 22:1333-9. 2009
    Renal cell carcinoma (RCC) shows organ-specific metastasis. This may be attributed to the fact that the CXCR4 G protein coupled receptor on RCC cells mediates chemo-attraction toward stromal-derived factor (SDF)-1 secreted by target ..
  35. ncbi Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4
    Federica Marchesi
    Department of Immunology and Cell Biology, Mario Negri Institute, Milan, Italy
    Cancer Res 64:8420-7. 2004
    ..cells from surgical samples of patients with pancreatic adenocarcinoma for expression of the chemokine receptor CXCR4. Six of 11 cell lines expressed detectable mRNA of CXCR4, with three cell lines (AsPC1, Capan1, and Hs766T) having ..
  36. pmc CXCR4/CXCL12 axis promotes VEGF-mediated tumor angiogenesis through Akt signaling pathway
    Zhongxing Liang
    Department of Hematology Oncology, Winship Cancer Institute, 1365C Clifton Road, N E, Clinic C5008, Atlanta, GA 30322, USA
    Biochem Biophys Res Commun 359:716-22. 2007
    CXC chemokine receptor 4 (CXCR4) has been shown to play a critical role in chemotaxis and homing, which are key steps in cancer metastasis...
  37. doi A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells
    Tanja Nicole Hartmann
    The Weizmann Institute of Science, Rehovot, 76100, Israel
    J Leukoc Biol 84:1130-40. 2008
    ..The binding of CXCL12 to its receptor CXCR4 triggers Gi protein signals for motility and integrin activation in many cell types...
  38. ncbi The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
    C C Bleul
    The Center for Blood Research, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 382:829-33. 1996
    ..Laboratory-adapted and some T-cell-line-tropic (T-tropic) primary viruses use the orphan chemokine receptor LESTR/fusin (also known as fusin), whereas macrophage-tropic primary HIV-1 isolates use CCR-5 and CCR-3 (refs 7-11), which are ..
  39. pmc Cryptic nature of a conserved, CD4-inducible V3 loop neutralization epitope in the native envelope glycoprotein oligomer of CCR5-restricted, but not CXCR4-using, primary human immunodeficiency virus type 1 strains
    Paolo Lusso
    Unit of Human Virology, Department of Biological and Technological Research DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    J Virol 79:6957-68. 2005
    ..sequential interactions with two cellular receptor molecules, CD4 and a chemokine receptor, most commonly CCR5 or CXCR4. However, antibody accessibility to such regions is hindered by diverse protective mechanisms, including shielding ..
  40. ncbi Molecular and clinical epidemiology of CXCR4-using HIV-1 in a large population of antiretroviral-naive individuals
    Zabrina L Brumme
    BC Centre for Excellence in HIV AIDS, St Paul s Hospital, and Faculty of Medicine, University of British Columbia, Canada
    J Infect Dis 192:466-74. 2005
    We wished to characterize the epidemiological and clinical correlates of CXCR4-using human immunodeficiency virus type 1 (HIV-1) ("X4 variants") in a cross-sectional analysis of a large population of antiretroviral-naive individuals.
  41. ncbi N-linked glycosylation of the HIV type-1 gp120 envelope glycoprotein as a major determinant of CCR5 and CXCR4 coreceptor utilization
    G Pollakis
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Biol Chem 276:13433-41. 2001
    ..The V1V2 region and its N-linked glycosylation degree were shown to confer CXCR4 usage and provide the virus with rapid replication kinetics...
  42. pmc CXCR4 mediates the proliferation of glioblastoma progenitor cells
    Moneeb Ehtesham
    Department of Neurological Surgery, Vanderbilt University Medical Center, 21st Avenue and Garland Street, Nashville, TN 37232, USA
    Cancer Lett 274:305-12. 2009
    ..To this end, we now report that the cell surface chemokine receptor, CXCR4, a known mediator of cancer cell proliferation and invasion, is overexpressed in primary glioblastoma progenitor ..
  43. pmc Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor
    Peter J McCormick
    The Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e8102. 2009
    ..syndrome is a rare immunodeficiency syndrome linked to heterozygous mutations of the chemokine receptor CXCR4 resulting in truncations of its cytoplasmic tail...
  44. pmc Membrane raft microdomains mediate lateral assemblies required for HIV-1 infection
    S Manes
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Madrid, Spain
    EMBO Rep 1:190-6. 2000
    ..These results indicate a general mechanism for HIV-1 envelope glycoprotein-mediated fusion by reorganization of membrane microdomains in the target cell, and offer new strategies for preventing HIV-1 infection...
  45. ncbi Morphological and molecular characterization of novel population of CXCR4+ SSEA-4+ Oct-4+ very small embryonic-like cells purified from human cord blood: preliminary report
    M Kucia
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 21:297-303. 2007
    Recently, we purified from adult murine bone marrow (BM) a population of CXCR4(+), Oct-4(+) SSEA-1(+), Sca-1(+) lin(-) CD45(-) very small embryonic-like (VSEL) stem cells and hypothesized that similar cells could be also present in human ..
  46. ncbi Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease
    Paolo A Hernandez
    Department of Human Genetics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    Nat Genet 34:70-4. 2003
    ..identification of truncating mutations in the cytoplasmic tail domain of the gene encoding chemokine receptor 4 (CXCR4)...
  47. pmc HIV-1 envelope-receptor interactions required for macrophage infection and implications for current HIV-1 cure strategies
    Paul R Gorry
    1 GPO Box 2284, Melbourne 3001, Victoria, Australia or University of Pennsylvania, 522 Johnson Pavilion, 36th and Hamilton Walk, Philadelphia, PA 19104 6060, USA E mail
    J Leukoc Biol 95:71-81. 2014
    ..mechanisms underlying HIV-1 tropism for macrophages are complex, involving enhanced and/or altered interactions with CD4, CCR5, and/or CXCR4, and that the nature of these interactions may depend on the anatomical location of the virus.
  48. pmc Effects of SDF-1-CXCR4 signaling on microRNA expression and tumorigenesis in estrogen receptor-alpha (ER-α)-positive breast cancer cells
    Lyndsay V Rhodes
    Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Exp Cell Res 317:2573-81. 2011
    ..Having previously shown the ability of the stromal-cell derived factor-1 (SDF-1)-CXCR4 signaling axis to promote primary tumorigenesis and hormone independence by overexpressing CXCR4 in MCF-7 cells, ..
  49. ncbi Mycobacterium tuberculosis-induced CXCR4 and chemokine expression leads to preferential X4 HIV-1 replication in human macrophages
    Yoshihiko Hoshino
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 172:6251-8. 2004
    ..alteration of the HIV-1 gp120 V3 sequence is associated with a shift in viral coreceptor use from CCR5 (CD195) to CXCR4 (CD184)...
  50. ncbi Cutting edge: CXCR4-Lo: molecular cloning and functional expression of a novel human CXCR4 splice variant
    S K Gupta
    Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    J Immunol 163:2368-72. 1999
    Human CXCR4 is a specific receptor for the CXC chemokine stromal cell-derived factor-1 (SDF-1) and a coreceptor for T cell line tropic strains of HIV-1...
  51. doi Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity
    Kenjiro Tadagaki
    INSERM, U1016, Institut Cochin, Paris, France
    Blood 119:4908-18. 2012
    ..We show that HCMV-encoded UL33 and UL78 form heteromers with CCR5 and CXCR4 chemokine receptors in transfected human embryonic kidney 293T cells and monocytic THP-1 cells...
  52. doi CXCR4 transfection of cord blood mesenchymal stromal cells with the use of cationic liposome enhances their migration toward stromal cell-derived factor-1
    Leah A Marquez-Curtis
    Canadian Blood Services R and D, Edmonton, Alberta, Canada
    Cytotherapy 15:840-9. 2013
    The interaction between stromal cell-derived factor (SDF)-1 and its receptor CXCR4 is one of the mechanisms by which mesenchymal stromal cells (MSCs) are recruited to sites of injury...
  53. doi Migration of CXCR4 gene-modified bone marrow-derived mesenchymal stem cells to the acute injured kidney
    Nanmei Liu
    Department of Nephrology, The 455th Hospital of PLA, Shanghai, 200052, China
    J Cell Biochem 114:2677-89. 2013
    ..This study investigated the effect of CXCR4 overexpression on BMSC migration to the AKI kidney and the possible mechanisms...
  54. pmc CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling
    A Dubrovska
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Br J Cancer 107:43-52. 2012
    ..However, tamoxifen resistance is an important clinical problem. Continuous treatment with conventional therapy may contribute to cancer progression in recurring cancers through the accumulation of drug-resistant cancer progenitors...
  55. ncbi The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway
    A J Vila-Coro
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia, CSIC Universidad Autonoma de Madrid, Campus de Cantoblanco, E 28049 Madrid, Spain
    FASEB J 13:1699-710. 1999
    The chemokine stromal cell-derived factor (SDF-1alpha), the ligand for the CXCR4 receptor, induces a wide variety of effects that include calcium mobilization, chemotactic responses, bone marrow myelopoiesis, neuronal patterning, and ..
  56. doi Stromal cell-derived factor-1/CXC receptor 4 and β1 integrin interaction regulates urokinase-type plasminogen activator expression in human colorectal cancer cells
    Wen Shih Huang
    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taiwan
    J Cell Physiol 227:1114-22. 2012
    The stromal cell-derived factor-1 (SDF-1)/CXC receptor 4 (CXCR4) axis has been shown to play a role in colorectal cancer progression...
  57. doi The disparate twins: a comparative study of CXCR4 and CXCR7 in SDF-1α-induced gene expression, invasion and chemosensitivity of colon cancer
    Doreen Heckmann
    Authors Affiliations Molecular Oncology of Solid Tumors, DKFZ German Cancer Research Center Department of Translational Oncology, National Center of Tumor Diseases NCT and DKFZ, Heidelberg Department of Experimental Surgery, Medical Faculty Mannheim Department of Radiation Oncology, University Medical Centre Mannheim, Medical Faculty Mannheim Medical Research Center, University Medical Centre Mannheim Centre for Biomedicine and Medical Technology Mannheim CBTM, University Medical Centre Mannheim Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Mannheim KIT Karlsruhe Campus Nord, Eggenstein Leopoldshafen and Center for Tumor Diagnostics and Therapy, Paracelsus Klinik, Osnabrueck, Germany
    Clin Cancer Res 20:604-16. 2014
    In colorectal cancer, increased expression of the CXC chemokine receptor 4 (CXCR4) has been shown to provoke metastatic disease due to the interaction with its ligand stromal cell-derived factor-1 (SDF-1)...
  58. pmc CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway
    Bing Zhu
    Laboratory of Neuroimmunology and Regenerative Therapy, University of Nebraska Medical Center, Omaha, Nebraska 68198 5930, USA
    Stem Cells 30:2571-83. 2012
    ..Although CXCL12 is known to function through its receptor CXCR4, recent data have suggested that CXCL12 binds to chemokine receptor CXCR7 with higher affinity than to CXCR4...
  59. pmc Selected amino acid mutations in HIV-1 B subtype gp41 are associated with specific gp120v₃ signatures in the regulation of co-receptor usage
    Salvatore Dimonte
    University of Rome Tor Vergata, Via Montpellier 1, Rome, Italy
    Retrovirology 8:33. 2011
    ..The binomial correlation phi coefficient was used to assess covariation among gp120V3 and gp41 mutations; subsequently the average linkage hierarchical agglomerative clustering was performed...
  60. ncbi Biological role and potential therapeutic targeting of the chemokine receptor CXCR4 in undifferentiated thyroid cancer
    Valentina De Falco
    Dipartimento di Biologia e Patologia Cellulare e Molecolare c o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR G Salvatore, Naples, Italy
    Cancer Res 67:11821-9. 2007
    ..b>CXCR4 is the receptor for the stromal cell-derived factor-1 (SDF-1)/CXCL12 chemokine and it is expressed in a variety of ..
  61. ncbi CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12
    Sreenivasa R Chinni
    Department of Urology, Wayne State University School of Medicine and The Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Prostate 66:32-48. 2006
    ..Recent evidence suggests that similar mechanisms may be active in cancer metastasis. Previously, we showed that metalloproteases (MMPs), and in particular MMP-9, play a role in prostate cancer (PC) expansion in bone...
  62. doi The chemokine CXCL12 and its receptor CXCR4 are implicated in human seminoma metastasis
    S C McIver
    ARC Centre of Excellence in Biotechnology and Development, Discipline of Biological Sciences School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Andrology 1:517-29. 2013
    ..CXCL12 and its receptors, CXCR4 and CXCR7, have been implicated in migration, proliferation and survival of gonocytes and their precursors and ..
  63. pmc Blockade of SDF-1/CXCR4 signalling inhibits pancreatic cancer progression in vitro via inactivation of canonical Wnt pathway
    Z Wang
    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi an Jiaotong University, Xi an, China
    Br J Cancer 99:1695-703. 2008
    ..CXC chemokine receptor 4 (CXCR4) was considered to have an important role in this process...
  64. pmc Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis
    Lorena Hernandez
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Breast Cancer Res 13:R128. 2011
    CXCL12-CXCR4 signaling has been shown to play a role in breast cancer progression by enhancing tumor growth, angiogenesis, triggering cancer cell invasion in vitro, and guiding cancer cells to their sites of metastasis...
  65. pmc Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors
    Wataru Shibata
    Department of Medicine, Division of Digestive and Liver Disease, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Gut 62:192-200. 2013
    Stromal cell-derived factor-1 (SDF-1/CXCL12), the main ligand for CXCR4, is overexpressed in human cancer. This study addressed the precise contribution of SDF-1 to gastric carcinogenesis.
  66. ncbi Migration of V delta 1 and V delta 2 T cells in response to CXCR3 and CXCR4 ligands in healthy donors and HIV-1-infected patients: competition by HIV-1 Tat
    Alessandro Poggi
    Laboratory of Immunology, National Institute fo Cancer Research, Largo R Benzi 10, I 16132, Genoa, Italy
    Blood 103:2205-13. 2004
    ..5%-4.8% vs 2.0%-3.3%). In these patients, both V delta 1 and V delta 2 T cells are CXCR3+CXCR4+, whereas in healthy donors CXCR4 was preferentially expressed on V delta 1 T lymphocytes...
  67. pmc HIV-1 induced bystander apoptosis
    Himanshu Garg
    Center of Excellence for Infectious Disease, Department of Biomedical Science, Texas Tech University Health Sciences Center, 5001 El Paso Dr, MSB 1 Annex, El Paso, TX 79905, USA
    Viruses 4:3020-43. 2012
  68. ncbi High expression of CXCR4 and CXCR7 predicts poor survival in gallbladder cancer
    X Yao
    Department of Hepatobiliary Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, China
    J Int Med Res 39:1253-64. 2011
    ..This study investigated whether the expression of CXC chemokine receptor types 4 and 7 (CXCR4 and CXCR7, respectively), determined immunohistochemically, was associated with clinicopathological ..
  69. doi Characterization of CXCR4 expression in chondrosarcoma of bone
    Shuting Bai
    Department of Pathology, University of Alabama at Birmingham, 35233, USA
    Arch Pathol Lab Med 135:753-8. 2011
    Alterations in molecular elements derived from the CXC chemokine receptor 4 (CXCR4)/stromal-derived factor 1 (SDF-1) cytokine system have been found to strongly correlate with neoplastic progression leading to metastasis in a number of ..
  70. pmc G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4
    Breann L Barker
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States
    Biochemistry 50:6933-41. 2011
    ..the phosphorylation of Ser-346 was required for proper agonist-induced internalization of the chemokine receptor CXCR4. Taken together, Hip has been identified as a novel substrate of GRK5 in vitro and in cells, and phosphorylation ..
  71. ncbi CXCR4, a potential predictive marker for docetaxel sensitivity in gastric cancer
    Li Xie
    The Comprehensive Cancer Center, of Drum Tower Hospital, affiliated to the Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing, PR China
    Anticancer Res 30:2209-16. 2010
    ..The aim of this study was to explore predictive genes involved in docetaxel sensitivity of gastric cancer...
  72. doi Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus
    Andrew Wang
    University of Texas Southwestern Medical Center, Dallas, TX 75390 8884, USA
    Arthritis Rheum 62:3436-46. 2010
    b>CXCR4 is a chemokine with multiple effects on the immune system. In murine lupus models, we demonstrated that monocytes, neutrophils, and B cells overexpressed CXCR4 and that its ligand, CXCL12, was up-regulated in diseased kidneys...
  73. ncbi Mu-opioid modulation of HIV-1 coreceptor expression and HIV-1 replication
    Amber D Steele
    Department of Microbiology and Immunology, Center for Substance Abuse Research, and the Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Virology 309:99-107. 2003
    ..In the present report, we have investigated the effect of opioids on the expression of the major HIV-1 coreceptors CXCR4 and CCR5. For these studies we have focused on opiates which are ligands for the mu-opioid receptor...
  74. doi Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion
    Nami Miyanishi
    Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3 14 1 Hiyoshi, Kohoku Ku, Yokohama 223 8522, Japan
    Biochem Biophys Res Commun 403:154-9. 2010
    ..DHMEQ inhibited invasion in vitro and the expression of CXCL12 and CXCR4. We found that neutralizing antibody against CXCR4 or knockdown of CXCR4 suppressed the invasion...
  75. ncbi Concomitant CXCR4 and CXCR7 expression predicts poor prognosis in renal cancer
    C D'Alterio
    Department of Oncological Immunology, National Cancer Institute, Naples, G Pascale, via Semmola, 80131 Naples, Italy
    Curr Cancer Drug Targets 10:772-81. 2010
    b>CXCR4 is a chemokine receptor implicated in the metastatic process...
  76. ncbi Leukocyte elastase negatively regulates Stromal cell-derived factor-1 (SDF-1)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4
    Agustin Valenzuela-Fernandez
    Unite d Immunologie Virale, INSERM U485 de l Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 277:15677-89. 2002
    Activation of CXCR4 by the CXC chemokine stromal cell-derived factor-1 (SDF-1) requires interaction of the amino-terminal domains of both molecules...
  77. doi Mesenchymal stromal cells may enhance metastasis of neuroblastoma via SDF-1/CXCR4 and SDF-1/CXCR7 signaling
    Ming Ma
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, PR China
    Cancer Lett 312:1-10. 2011
    ..Neuroblastoma expressed both of the SDF-1 receptors CXCR4 and CXCR7...
  78. doi B lymphocytes that migrate to tuberculous pleural fluid via the SDF-1/CXCR4 axis actively respond to antigens specific for Mycobacterium tuberculosis
    Lian Feng
    Institute of Immunology, Zhongshan School of Medicine, Key Laboratory of Tropical Disease Control Research of Ministry of Education, Sun Yat Sen University, Guangzhou, PR China
    Eur J Immunol 41:3261-9. 2011
    ..Furthermore, we found significantly higher expression of CXCR4 on B cells in the PF, and a chemotaxis assay showed that B cells in the PF were more responsive to stromal cell-..
  79. pmc Molecular switch for alternative conformations of the HIV-1 V3 region: implications for phenotype conversion
    Osnat Rosen
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 103:13950-5. 2006
    HIV-1 coreceptor usage plays a critical role in virus tropism and pathogenesis. A switch from CCR5- to CXCR4-using viruses occurs during the course of HIV-1 infection and correlates with subsequent disease progression...
  80. doi IL-17 and tumour necrosis factor α combination induces a HIF-1α-dependent invasive phenotype in synoviocytes
    Arnaud Hot
    Department of Clinical Immunology and Rheumatology and Immunogenomics and Inflammation Research Unit, Hopital Edouard Herriot, University of Lyon 1, Lyon, France
    Ann Rheum Dis 71:1393-401. 2012
    ..To examine the effect of interleukin-17 (IL-17) on rheumatoid arthritis (RA) synoviocyte migration and invasiveness...
  81. ncbi Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1
    Ombretta Salvucci
    Experimental Transplantation and Immunology Branch and the Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 99:2703-11. 2002
    The chemokine stromal-derived factor-1 (SDF-1) and its unique receptor, CXCR4, are required for normal cardiovascular development, but a critical role for SDF-1 in postnatal vascular remodeling and the mechanisms underlying SDF-1/CXCR-4 ..
  82. pmc The CXCR4 antagonist AMD3100 efficiently inhibits cell-surface-expressed human immunodeficiency virus type 1 envelope-induced apoptosis
    J Blanco
    Institut de Recerca de la SIDA Caixa, Laboratori de Retrovirologia, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Catalonia, Spain
    Antimicrob Agents Chemother 44:51-6. 2000 involved in both infected and uninfected cell death via its interaction with cellular receptors CD4 and CXCR4. We studied the effect of the blockade of CXCR4 receptors by the agonist stromal derived factor (SDF-1alpha) and ..
  83. pmc Extreme genetic divergence is required for coreceptor switching in HIV-1 subtype C
    Mia Coetzer
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Acquir Immune Defic Syndr 56:9-15. 2011
    Coreceptor switching from CCR5 to CXCR4 is less common in subtype C HIV-1 infection than in subtype B for reasons that are unclear...
  84. doi CXCR4 expression functionally discriminates centroblasts versus centrocytes within human germinal center B cells
    Gersende Caron
    Unité 917, Faculte de Medecine, Institut National de la Sante et de la Recherche Medicale, Universite Rennes 1, Rennes, France
    J Immunol 182:7595-602. 2009 for the first time to separate these two subpopulations based on the expression of the chemokine receptor CXCR4 allowing their characterization...
  85. ncbi HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases
    C K Ullrich
    Divisions of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Blood 96:1438-42. 2000
    ..Recently, the alpha-chemokine receptor CXCR4 has been reported to mediate apoptosis in neuronal cells and in CD4(+) and CD8(+) T cells after its binding to HIV-..
  86. pmc Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells
    K E Luker
    Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Oncogene 31:4750-8. 2012
    Chemokine CXCL12 and receptor CXCR4 control multiple steps in primary tumor growth and metastasis in breast cancer and more than 20 other human malignancies...
  87. pmc Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: In vivo neovascularization induced by stromal-derived factor-1alpha
    R Salcedo
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Frederick Cancer Research and Development Center, Frederick, MD 21702 1202, USA
    Am J Pathol 154:1125-35. 1999
    ..CXC chemokine receptors in resting human umbilical vein endothelial cells (HUVECs) and detected low levels of only CXCR4 mRNA...
  88. ncbi The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
    H Choe
    Division of Human Retrovirology Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cell 85:1135-48. 1996
    ..The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary HIV-1 isolates...
  89. doi The expression of CXCL12 and CXCR4 in gastric cancer and their correlation to lymph node metastasis
    Jieer Ying
    Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, 301122 Zhejiang, China
    Med Oncol 29:1716-22. 2012
    The purpose of this study was to investigate the expression of CXCL12 and its receptor CXCR4 in gastric cancer and to determine their relationship with lymph node metastasis...
  90. doi New insight into the SDF-1/CXCR4 axis in a breast carcinoma model: hypoxia-induced endothelial SDF-1 and tumor cell CXCR4 are required for tumor cell intravasation
    Fengyan Jin
    The First Hospital of Jilin University, Changchun, China
    Mol Cancer Res 10:1021-31. 2012
    The SDF-1/CXCR4 axis has been implicated in breast cancer metastasis...
  91. ncbi Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    Y R Zou
    Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York 10016, USA
    Nature 393:595-9. 1998
    ..The chemokine receptor CXCR4 is broadly expressed in cells of both the immune and the central nervous systems and can mediate migration of ..
  92. pmc The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network
    M Fareh
    INSERM U898 UNSA, Cellules Souches, Développement et Cancer, Faculte de Medecine, Av Valombrose, Nice, France
    Cell Death Differ 19:232-44. 2012
    ..the stemness signature, self-renewal, and cell infiltration within a host brain tissue, through inhibition of the CXCR4 pathway...
  93. pmc Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma
    Masahiro Kato
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Breast Cancer Res 5:R144-50. 2003
    The stromal cell-derived factor-1/CXC chemokine receptor-4 (SDF-1/CXCR4) signal has been shown to be important in various immunological reactions...
  94. doi Nuclear expression of CXCR4 is associated with advanced colorectal cancer
    Shang Chiung Wang
    Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang Ming University, Taipei, Taiwan
    Int J Colorectal Dis 25:1185-91. 2010
    b>CXCR4 and its ligand, SDF-1alpha, play an important role in the targeted metastasis of colon cancer...
  95. ncbi The expression of CXCR4/CXCL12 in first-trimester human trophoblast cells
    Xia Wu
    Laboratory of Reproductive Immunology, Institute of Obstetrics and Gynecology, Fudan University, Shanghai 200011, China
    Biol Reprod 70:1877-85. 2004
    ..Among these receptors, CXCR4 was found highly transcribed...
  96. ncbi Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradient
    Marcin Wysoczynski
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Blood 105:40-8. 2005
    ..was dependent on cholesterol content in the cell membrane and on the incorporation of the SDF-1 binding receptor CXCR4 and the small GTPase Rac-1 into membrane lipid rafts...
  97. ncbi Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
    Peter Staller
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nature 425:307-11. 2003
    ..For example, malignant breast cancer cells express the chemokine receptor CXCR4 and commonly metastasize to organs that are an abundant source of the CXCR4-specific ligand stromal cell-derived ..
  98. pmc Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling
    Karl Balabanian
    INSERM U819, Paris, France
    J Clin Invest 118:1074-84. 2008
    ..infections, and myelokathexis (WHIM) syndrome, a rare immunodeficiency, and bearing a wild-type CXCR4 ORF (WHIM(WT)) display impaired CXCR4 internalization and desensitization upon exposure to CXCL12...
  99. doi Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer
    Takuya Akashi
    Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Cancer Sci 99:539-42. 2008
    The chemokine receptor CXCR4 has been reported to be aberrantly expressed in human cancers and has also been shown to participate in the development of cancer metastasis...
  100. pmc Methamphetamine enhances HIV-1 infectivity in monocyte derived dendritic cells
    Madhavan P N Nair
    Department of Immunology, College of Medicine, Florida International University, Miami, FL 33155, USA
    J Neuroimmune Pharmacol 4:129-39. 2009
    ..Meth induces increased HIV-1 infection in association with an increase in the HIV-1 coreceptors, CXCR4 and CCR5, and infection is mediated by downregulation of extracellular-regulated kinase (ERK2) and the ..
  101. pmc Regulation of expression of stromal-derived factor-1 receptors: CXCR4 and CXCR7 in human rhabdomyosarcomas
    Maciej Tarnowski
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 South Floyd Street, Room 107, Louisville, KY 40202, USA
    Mol Cancer Res 8:1-14. 2010
    Rhabdomyosarcomas (RMS) express CXCR4 and CXCR7 receptors that bind prometastatic alpha-chemokine stromal-derived factor-1 (SDF-1)...

Research Grants68

  1. HIV, Chemokine Receptors, and Vascular Smooth Muscle
    ALISON SCHECTER; Fiscal Year: 2007
    ..SMC), the major cellular components of the vessel wall, possess the functional chemokine receptors, CCR5, and CXCR4. Engagement of these receptors results in a marked induction of tissue factor (TF) activity...
  2. Cellular and molecular mechanisms of gp120 neurotoxicity
    Italo Mocchetti; Fiscal Year: 2012
    ..Preliminary evidence has shown that the chemokine receptor CXCR4 promotes endocytosis of T-tropic gp120 into neurons...
  3. Chemokine Antagonist, Opioid Medication and HIV gp120
    Khalid Benamar; Fiscal Year: 2012
    ..Particularly, we have demonstrated that the activation of CXCR4 in the PAG diminishes the analgesic efficacy of morphine (Adler et al., 2006)...
  4. Structural Basis for Chemokine Function
    Brian F Volkman; Fiscal Year: 2013
    ..Stromal cell-derived factor-1 (SDF1/ CXCL12) and its cognate receptors CXCR4 and CXCR7 are essential for life and play unique roles in human development, HIV infection, stem cell homing and ..
    Haribabu Bodduluri; Fiscal Year: 2002
    ..Recently, chemokine receptors CCR5 or CXCR4 were identified as essential co-receptors for the entry of human immunodeficiency virus HIV-1 into CD4 positive ..
  6. Peptide-based nanoparticle inhibition of CCR3-mediated inflammatory cell recruitm
    Vadim V Gaponenko; Fiscal Year: 2013
    ..We used this approach to develop peptide-based nanoparticles that antagonize CXCR4, a chemokine receptor similar to CCR3...
  7. CXCR4-Vagal Tone and Gastric motility
    Richard C Rogers; Fiscal Year: 2013
    ..suggest a central hypothesis: that SDF1 generated within the CNS causes gastrointestinal dysfunction via action on CXCR4 receptors on neuronal elements of the gastric vago-vagal reflex control circuitry in the dorsal medulla...
  8. Targeting the CXCL12/CXCR4 Axis towards the Therapy of Metastatic Cancers
    Rongshi Li; Fiscal Year: 2013
    ..project is to discover novel chemical probes that are capable of potently and selectively disrupting the CXCL12/CXCR4 protein-protein binding...
  9. CXCR4 Expression and Function in Astrocytes
    ETTY BENVENISTE; Fiscal Year: 2004
    ..Astrocytes express receptors for numerous chemokines, including CXCR4. CXCR4 is the exclusive receptor for the chemokine stromal cell-derived factor-I (SDF-l)...
  10. Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
    Alexandra L Howell; Fiscal Year: 2013
    ..However, APC also express CD4, CCR5, and CXCR4 receptors and can become productively infected with HIV-1...
  11. Matrix Metalloproteinases and Spinal Cord Injury
    Linda J Noble; Fiscal Year: 2010
    ..Aims 2 and 3 will examine synergism between chemokine stromal-derived factor-1 (SDF-1), its receptor, CXCR4, and MMP-9 in the homing and transendothelial migration of BMDMs to the injured cord...
  12. Oncolytic Viruses with Therapeutic Genes in the Treatment of Breast Cancer
    DANUTA B KOZBOR; Fiscal Year: 2013
    ..our preliminary results demonstrated that oncolytic vaccinia virus (OVV) expressing an antagonist of the CXCR4 receptor for CXCL12 chemokine (OVV- CXCR4-A-Fc) was more effective in inhibiting growth of triple-negative (TN) ..
  13. Biliary Epithelial Cell-derived SDF-1a in Hepatic Fibrogenesis and Inflammation
    Yedidya Saiman; Fiscal Year: 2013
    ..metastasis, angiogenesis and migration of lymphocytes to sites of injury through interactions with its receptor, CXCR4. Hepatic stellate cell (HSC) activation is central feature of fibrosis in all forms of chronic liver injury and we ..
  14. Stem cells in liver regeneration: fusion or plasticity
    Bryon E Petersen; Fiscal Year: 2013
    ..aim 2: We hypothesize that activation of the MEK and PI3K signal transduction pathways following SDF-1 binding to CXCR4 receptor on the cell membrane enhances both proliferation and migration of liver oval cells...
  15. Imaging and targeting metastatic disease
    Sridhar Nimmagadda; Fiscal Year: 2013
    ..or CXCL12) is secreted by stroma in potential metastatic sites and attracts circulating chemokine receptor 4 (CXCR4) expressing cells...
    George J Schwartz; Fiscal Year: 2013
    ..Aim 3 will determine the role of the SDF-1/CXCR4 pathway as an early response in the adaptation to acidosis...
  17. Pathogenesis and Therapy of HIV-Related Neuropathic Pain
    Shuanglin Hao; Fiscal Year: 2010
    ..Studies in vitro have shown that the coat glycoprotein gp120 of HIV, acting through the CXCR4 receptor can: 1) stimulate Schwann cells to release RANTES and then induce release of tumor necrosis factor alpha (..
  18. Quantifying Changes in Neural Stem Cell Lineages in the Aging Niche
    Sally Temple; Fiscal Year: 2013
    ..age-related declines in NSC activity by exploring the role that the chemokine SDF1 and the corresponding CXCR4 receptor play in the aging process...
  19. Cajal-Retzius Cells and Neuronal Signaling in Postnatal Cortical Networks
    Gianmaria Maccaferri; Fiscal Year: 2013
    ..Both cell types are a rich source of the chemokine stromal cell-derived factor 1 (SDF-1), whose CXCR4 receptors are abundantly expressed by hippocampal Cajal-Retzius cells...
  20. Stabilization of CXCR4 and its complexes for high resolution structural studies
    QINGHAI contact ZHANG; Fiscal Year: 2010
    ..provided by applicant): Experimentally determining the 3-D structure of the G protein-coupled receptor (GPCR), CXCR4 and its complexes, the overall goal of the proposed study, is critical in developing a deeper understanding of its ..
  21. Bone marrow derived neural stem cell therapy for glioma
    John S Yu; Fiscal Year: 2013
    ..We propose to: AIM 1: Test the hypothesis that BM-NSC migration to the tumor vascular niche is dependent on CXCR4 expression, CXCR4 interaction with SDF-1, CXCR4 receptor signaling, and downstream induction of the PI3K/Akt ..
  22. Role of Slit in CXCR4-Mediated Breast Cancer Metastasis
    Ramesh Ganju; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The chemokine receptor CXCR4 and its ligand CXCL12 play a critical role in breast cancer metastasis...
    Ziwei Huang; Fiscal Year: 2010
    ..the structure-function relationship and mechanism for binding and signaling of chemokine receptors, particularly CXCR4 that is one of two principal coreceptors required for the cellular entry of human immunodeficiency virus type 1 (..
    Jacob Anglister; Fiscal Year: 2010
    ..This binding triggers a conformational change in gp120 that forms another binding site to either CCR5 or CXCR4 chemokine receptors, which serve as co-receptors for HIV-1 binding...
  25. Transnasal Delivery of Chemokine Analogs in mouse NeuroAIDS Models
    Stuart A Lipton; Fiscal Year: 2013
    ..As potential treatment, we and our collaborators have synthesized new peptide inhibitors of chemokine receptors (CXCR4 and CCR5, which are co-receptors for HIV/gp120), and found that these novel synthetically and modularly modified (..
  26. Synthetic Fabs for Crystallization of Chemokine:Receptor Complexes
    Tracy M Handel; Fiscal Year: 2013
    ..field of GPCR structural biology with the determination of many new structures including one chemokine receptor, CXCR4, in complex with a small molecule and cyclic peptide antagonist...
  27. HIV-1 gp120 Mediated Chemotaxis of Blood Cells
    Ramesh Ganju; Fiscal Year: 2005
    DESCRIPTION: (provided by applicant) Chemokine receptors CXCR4 and CCR5 play critical roles in H1V infection...
  28. Chemokines and Macrophages in HIV Neuronal Apoptosis
    Stuart Lipton; Fiscal Year: 2003
    ..Microglia, astrocytes and neurons express co-receptors for HIV-1, namely the chemokine receptors CCR5 and CXCR4. Using chemokine receptor knock-out mice, the objectives of this application are to further elucidate the role of ..
  29. A New Insight into HIV-1 Latency Through a Novel in Vitro System
    Fabio Romerio; Fiscal Year: 2010
    ..are responsible for virus transmission during primary infection and persist throughout disease, emergence of CXCR4-tropic strains that occurs in about half of all cases is associated with faster disease progression...
  30. Rational Design of HIV Fusion Inhibitors Targeting gp41
    Shibo Jiang; Fiscal Year: 2010
    ..the target cell is initiated by binding of the envelope glycoprotein surface unit gp120 to CD4 and a coreceptor (CXCR4 or CCR5) followed by gp41 refolding from its native conformation to a fusion-active conformation, a six-helix ..
    Stephen W Chensue; Fiscal Year: 2013
    ..The studies proposed will aid the design of improved approaches to vaccine development and therapies to control chronic destructive inflammatory responses. ..
  32. Targeting fibrocytes in Duchenne muscular dystrophy
    Lan Zhou; Fiscal Year: 2013
    ..We further showed that mdx diaphragm fibrocytes expressed chemokine receptors CCR1, CCR2, CCR5, and CXCR4. This study is to address our central hypothesis that fibrocytes play a pathogenic role in skeletal muscle ..
  33. Id3/B Lymphocytes and Atherosclerosis
    Coleen A McNamara; Fiscal Year: 2010
    ..Our data further provides evidence that Id3 regulates B cell expression of specific chemokines: CXCR4, CXCR7, and CCR6 but not CXCR5 or CCR7 (chemokine receptors known to regulate B cell homing to lymphoid tissue), ..
    Richard J Miller; Fiscal Year: 2013
    ..Thus, in CXCR4 chemokine receptor knockout mice structures in the nervous system such as the dentate gyrus (central nervous ..
  35. CXCR4 regulation of tumor progression in Multiple Myeloma
    Irene M Ghobrial; Fiscal Year: 2012 a central role in lymphocyte trafficking and homing, specifically the chemokine SDF-1, and its receptors, CXCR4 along with the recently identified receptor CXCR7...
    Georges Herbein; Fiscal Year: 2000
    ..Following interaction of CXCR4 with the HIV envelope gp120, tumor necrosis factor receptor 2 (TNFR2) is up-regulated on Cd8+ T cells and tumor ..
    ROBYN SUE KLEIN; Fiscal Year: 2013
    ..Additionally, we will determine the role of CXCR4 in T cell subset entry at the BBB;2) Identify molecular mechanisms involved in WNV entry and effects at the BBB...
  38. Mechanisms of KSHV-Induced Cellular Transformation
    Ashlee V Moses; Fiscal Year: 2013
    ..The SDF-1/CXCR4 axis is one of the main chemokine/CR interactions associated with tumor growth, angiogenesis and metastasis...
  39. Role of NFAT and NFAT-Induced Genes in Carcinoma
    Alex Toker; Fiscal Year: 2013
    ..We will determine the contribution of chemokine receptors including CXCR-2, CCR-2, XCR-1 and CXCR4 and their ligands in NFAT-mediated invasion, and the role of paracrine and autocrine signaling...
  40. Molecular Imaging of Chemokine Receptor Signaling
    Gary D Luker; Fiscal Year: 2013
    ..In particular, our laboratory and others have shown that chemokine receptors CXCR4 and CXCR7 are upregulated on malignant cells in breast and lung cancer...
  41. Opioid Modulation of Inflammatory Monocyte Activity Involved in HIV Susceptibilit
    Thomas J Rogers; Fiscal Year: 2012
    ..has shown that acute mu opioid administration induces the expression of the chemokine receptors CCR5 and CXCR4. We will extend these studies to determine the biochemical basis for these effects using cloned molecular ..
  42. 2010 Chemotactic Cytokines Gordon Research Conference
    Sergio A Lira; Fiscal Year: 2010
    ..In addition, 2 chemokine receptors (CCR5 and CXCR4) have been shown to play profound roles in HIV pathogenesis through their ability to act as co-receptors for viral ..
  43. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2009
    ..may play a crucial role in directing to the BM the RMS cells that express the receptor for SDF-1, CXCR4. To investigate the mechanisms operating in the metastasis of RMS and develop a new therapeutic approach to ..
    Elias Lolis; Fiscal Year: 2002
    ..One chemokine, stromal cell-derived factor SDF-1a is the natural agonist for the receptor CXCR4. The CXCR4 receptor has also been identified as the co-receptor for T-tropic, syncytium inducing strains of HIV-1...
    Waldemar Popik; Fiscal Year: 2001
    ..CD4 receptors, the question arises whether the binding of HIV-1 virions to the newly described HIV-1 coreceptor, CXCR4 participates or contributes to this signaling...
  46. Suppression of pathogenic autoantibodies in lupus by inhibition of AID
    John D Mountz; Fiscal Year: 2012
    ..Upregulation of these genes decrease, rather than increase, the signaling to the CXCR4 and CXCR5 chemokine receptors expressed on GC B and T cells...
  47. Personalized therapeutics for inhibiting breast cancer metastasis
    DEBRA AUGUSTE; Fiscal Year: 2012
    ..and proximity of two G- protein coupled receptors that facilitate tumor chemotaxis, CXC chemokine receptor type 4 (CXCR4) and CC chemokine receptor type 7 (CCR7)...
  48. Genetic Regulation of B Lymphocyte Aortic Homing and Atheroprotection
    Coleen A McNamara; Fiscal Year: 2013 mice mediated by immune cells called B lymphocytes, and discovered molecular (Id3) and cellular (CCR6 and CXCR4) factors in B lymphocytes mediating this effect...
  49. Regulation of CXCR4 by cognate and non-cognate ligands
    Elias Lolis; Fiscal Year: 2013
    b>CXCR4 is a G-protein coupled receptor activated by a sole chemokine agonist, CXCL12, and functions to cause the migration of cells to the appropriate anatomical location during embryonic development and in response to stress in adults...
  50. Structural Biology of G-Protein Coupled Receptors
    Wayne A Hendrickson; Fiscal Year: 2011
    ..glycoprotein hormone receptors, FSHR and LHR;and human chemokine receptors that are co-opted by HIV, CCR5 and CXCR4. Continued studies are also planned for other GPCRs...
  51. HIV drug abusers, polymorphisms and brain plasticity
    Italo Mocchetti; Fiscal Year: 2012
    ..Chronic opiates alter the expression of chemokine receptors CCR5 and CXCR4, known to mediate the neurotoxic effect of HIV...
  52. Role of chemokine receptors in neuronal survival
    Olimpia Meucci; Fiscal Year: 2013
    ..funding periods that revealed novel and unexpected roles of the chemokine CXCL12, and its primary receptor CXCR4, on central neurons and glia...
  53. Regulation of cardiac myocytes by HIV-gp120
    MITCHELL SIMON FINKEL; Fiscal Year: 2010
    ..our initial 3 yrs of RO-1 funding to study the negative inotropic effect of gp120 on ARVM mediated through a novel CXCR4-p38MAPkinase-iPLA2-froponin I signaling pathway that supports our initial hypothesis: HIV gp120 regulates cardiac ..
  54. G protein-coupled receptor kinase 3 regulation of leukocyte function in inflammat
    TERESA KATHLEEN TARRANT; Fiscal Year: 2013
    ..Although most chemokine receptors have multiple ligands, CXCR4 is unique in its monogamous relationship with CXCL12 (SDF-1)...
  55. Evaluating self-protection of Th17 cells against HIV-1 by CCR5 Ligands Synthesis
    Yelina Alvarez; Fiscal Year: 2013
    ..Subsequently, we will determine the susceptibility of TH17 cells to in vitro challenge by CCR5 tropic vs. CXCR4 tropic HIV viruses...
  56. Opioid and Chemokine Receptor Interactions Relative to HIV
    Thomas J Rogers; Fiscal Year: 2013
    ..that the activation of the ?-opioid receptor induces a significant increase in the level of expression of CCR5 and CXCR4 in both monocytes and T cells. In contrast, activation of the ?-opioid receptor has the opposing effect...
  57. Development of anti-CXCR4 compounds as anti-metastatic, angiogenic drug
    Hyunsuk Shim; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The overall objective is to develop potent anti-CXCR4 drugs that are specific and safe...
  58. CCR5 & CXCR4 Antagonist & Agonist Binding Site Structure
    EDWARD DRATZ; Fiscal Year: 2009 a complex process that requires binding of the HIV envelope protein gp120 to a cellular co-receptor (CCR5 or CXCR4)...
  59. Foldamers: Novel Ligands for Diverse Protein Surfaces
    Alanna Schepartz; Fiscal Year: 2013
    ..We also describe beta-peptides that either inhibit or activate CXCR4 and CCR5 chemokine receptors from within the plasma membrane...
    Shahin Rafii; Fiscal Year: 2002
    ..The investigators have discovered that mature polypoid MKs express the chemokine receptor (HIV co-receptor): CXCR4. Stromal Derived Factor 1 (SDF1) which is the ligand for the CXCR4, promotes transmigration of MKs through BMEC ..
  61. Heterodimerization of CXCR4 and CB2 Inhibits Prostate Cancer Cell Movement
    Cimona V Hinton; Fiscal Year: 2013
    ..Upon activation by stromal cell derived factor 1 alpha (SDF1 alpha), the G-protein-coupled chemokine receptor, CXCR4, generates signals that eventually lead to the metastatic spread and survival of primary tumor cells in distal ..
  62. Genetic Analy. of Chemokine Receptors in T Cell Develop.
    Lishan Su; Fiscal Year: 2003
    ..Multiple chemokines (SDF-1, TECK, MDC, IP-10, and ELC) and corresponding CKR (CXCR4, CCR9, CCR4, CXCR3 and CCR7) are expressed in the thymus...
  63. Covalently Tethered Chemokines and HIV-1 Inhibition
    Wuyuan Lu; Fiscal Year: 2005
    ..used by T cell line-tropic (X4 strain) and macrophagetropic (R5 strain) HIV-1 isolates, the chemokine receptors CXCR4 and CCR5 mediate direct fusion of the virus and target cell membranes...
  64. The Role of Mast Cells in Lung Inflammation
    Joshua Boyce; Fiscal Year: 2006
    ..These hPrMC express 4 functional cell surface chemokine receptors; CXCR2, CXCR4, CCR3, and CCR5...
  65. G-protein Signaling in Zebrafish Primordial Germ Cell Migration
    Fang Lin; Fiscal Year: 2010
    ..In Aim 1,1 will characterize G(3y function in PGC migration, and test my hypothesis that Gpy transmit the SDF1a/CXCR4 signal. I will also identify the downstream effectors of Gpy that are required for PGC migration...
  66. Natural IgM antilymphocyte autoantibodies inhibit HIV-1
    PETER LOBO; Fiscal Year: 2003
    ..The latency period is determined by host factors that control viral infectivity. Chemokine receptors (CCR5 and CXCR4) serve as co-receptors for HIV-1 entry into cells...
  67. Molecular Imaging of Metastatic Potential in SCCHN by Targeting VLA-4 and CXCR4
    Carolyn J Anderson; Fiscal Year: 2013
    ..imaging agents to quantify integrin (also called very late antigen 4, or VLA-4) and CXC chemokine receptor 4 (CXCR4) levels, both of which play a putative role in the metastasis of head and neck cancer to lymph nodes...
  68. CCR5 and CXCR4 Binding Chemokines and Oral HIV Infection
    Grace John Stewart; Fiscal Year: 2005
    ..Chemokines, the natural ligands for the HIV-1 co-receptors CCR5 and CXCR4, are potential candidates...