CXCR4

Summary

Gene Symbol: CXCR4
Description: chemokine (C-X-C motif) receptor 4
Alias: CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, C-X-C chemokine receptor type 4, CD184 antigen, SDF-1 receptor, fusin, leukocyte-derived seven transmembrane domain receptor, lipopolysaccharide-associated protein 3, neuropeptide Y receptor Y3, seven transmembrane helix receptor, seven-transmembrane-segment receptor, spleen, stromal cell-derived factor 1 receptor
Species: human

Top Publications

  1. ncbi HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    Y Feng
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, MD 20892, USA
    Science 272:872-7. 1996
  2. doi CXCR4 and cancer
    Bungo Furusato
    Center for Prostate Disease Research, Department of Surgery, Uniformed Service University of the Health Sciences, 1530 E Jefferson Street, Rockville, MD 20852, USA
    Pathol Int 60:497-505. 2010
  3. pmc Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway
    Jaime Imitola
    Center for Neurologic Diseases, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:18117-22. 2004
  4. pmc A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors
    Joshua B Rubin
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:13513-8. 2003
  5. doi The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects
    Kirsten Hattermann
    Department of Anatomy, University of Kiel, Center, Kiel, Germany
    Cancer Res 70:3299-308. 2010
  6. ncbi CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion
    Jolanta Libura
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Blood 100:2597-606. 2002
  7. ncbi Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    Y R Zou
    Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York 10016, USA
    Nature 393:595-9. 1998
  8. pmc Detection of inferred CCR5- and CXCR4-using HIV-1 variants and evolutionary intermediates using ultra-deep pyrosequencing
    Evelien M Bunnik
    Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS Pathog 7:e1002106. 2011
  9. ncbi Structural basis for coreceptor selectivity by the HIV type 1 V3 loop
    Timothy Cardozo
    Department of Pharmacology and New York University School of Medicine, New York, NY 10016, USA
    AIDS Res Hum Retroviruses 23:415-26. 2007
  10. ncbi Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis
    Merav Darash-Yahana
    Goldyne Savad Institute of Gene Therapy, HBRC, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    FASEB J 18:1240-2. 2004

Research Grants

  1. HIV, Chemokine Receptors, and Vascular Smooth Muscle
    ALISON SCHECTER; Fiscal Year: 2007
  2. HIV, Chemokine Receptors, and Vascular Smooth Muscle
    ALISON SCHECTER; Fiscal Year: 2003
  3. HIV, Chemokine Receptors, and Vascular Smooth
    ALISON SCHECTER; Fiscal Year: 2004
  4. HIV, Chemokine Receptors, and Vascular Smooth
    ALISON SCHECTER; Fiscal Year: 2006
  5. HIV, Chemokine Receptors, and Vascular Smooth
    ALISON SCHECTER; Fiscal Year: 2005
  6. Cellular and molecular mechanisms of gp120 neurotoxicity
    Italo Mocchetti; Fiscal Year: 2011
  7. Oncolytic Viruses with Therapeutic Genes in the Treatment of Breast Cancer
    DANUTA B KOZBOR; Fiscal Year: 2013
  8. Stem cells in liver regeneration: fusion or plasticity
    Bryon E Petersen; Fiscal Year: 2013
  9. Imaging and targeting metastatic disease
    Sridhar Nimmagadda; Fiscal Year: 2013
  10. BICARBONATE TRANSPORT BY THE MATURING RENAL TUBULE
    George J Schwartz; Fiscal Year: 2013

Detail Information

Publications295 found, 100 shown here

  1. ncbi HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    Y Feng
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, MD 20892, USA
    Science 272:872-7. 1996
    ..This protein, designated "fusin," is a putative G protein-coupled receptor with seven transmembrane segments...
  2. doi CXCR4 and cancer
    Bungo Furusato
    Center for Prostate Disease Research, Department of Surgery, Uniformed Service University of the Health Sciences, 1530 E Jefferson Street, Rockville, MD 20852, USA
    Pathol Int 60:497-505. 2010
    The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors and has been identified to play a crucial role in a number of biological processes, including the trafficking and homeostasis of immune cells ..
  3. pmc Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway
    Jaime Imitola
    Center for Neurologic Diseases, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:18117-22. 2004
    ..NSCs express CXC chemokine receptor 4 (CXCR4), the cognate receptor for SDF-1alpha...
  4. pmc A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors
    Joshua B Rubin
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:13513-8. 2003
    ..Here we show that activation of the Gi protein-coupled receptor CXCR4 is critical for the growth of both malignant neuronal and glial tumors...
  5. doi The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects
    Kirsten Hattermann
    Department of Anatomy, University of Kiel, Center, Kiel, Germany
    Cancer Res 70:3299-308. 2010
    The chemokine CXCL12/stromal cell-derived factor-1 and its receptor CXCR4 play a major role in tumor invasion, proliferation, and metastasis. Recently, CXCR7 was identified as a novel, alternate receptor for CXCL12 and CXCL11/I-TAC...
  6. ncbi CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion
    Jolanta Libura
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Blood 100:2597-606. 2002
    We hypothesized that the CXC chemokine receptor-4 (CXCR4)-stromal-derived factor-1 (SDF-1) axis may be involved in metastasis of CXCR4(+) tumor cells into the bone marrow and lymph nodes, which secrete the alpha-chemokine SDF-1...
  7. ncbi Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    Y R Zou
    Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York 10016, USA
    Nature 393:595-9. 1998
    ..The chemokine receptor CXCR4 is broadly expressed in cells of both the immune and the central nervous systems and can mediate migration of ..
  8. pmc Detection of inferred CCR5- and CXCR4-using HIV-1 variants and evolutionary intermediates using ultra-deep pyrosequencing
    Evelien M Bunnik
    Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS Pathog 7:e1002106. 2011
    The emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants is associated with accelerated disease progression...
  9. ncbi Structural basis for coreceptor selectivity by the HIV type 1 V3 loop
    Timothy Cardozo
    Department of Pharmacology and New York University School of Medicine, New York, NY 10016, USA
    AIDS Res Hum Retroviruses 23:415-26. 2007
    ..The CXCR4 and CCR5 chemokine receptors are used by "X4-tropic" and "R5-tropic" viruses, respectively...
  10. ncbi Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis
    Merav Darash-Yahana
    Goldyne Savad Institute of Gene Therapy, HBRC, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    FASEB J 18:1240-2. 2004
    ..We found that high expression levels of the chemokine receptor CXCR4 correlated with the presence of metastatic disease in prostate cancer patients...
  11. pmc LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection
    Paul J Vorster
    Department of Molecular and Microbiology, George Mason University, Manassas, Virginia 20110, USA
    J Biol Chem 286:12554-64. 2011
    ..of the Rack-PAK-LIMK pathway, and that knockdown of LIMK through siRNA decreases filamentous actin, increases CXCR4 trafficking, and diminishes viral DNA synthesis...
  12. ncbi The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
    H Choe
    Division of Human Retrovirology Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cell 85:1135-48. 1996
    ..The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary HIV-1 isolates...
  13. pmc Coreceptor tropism in human immunodeficiency virus type 1 subtype D: high prevalence of CXCR4 tropism and heterogeneous composition of viral populations
    Wei Huang
    Monogram Biosciences, 345 Oyster Point Blvd, South San Francisco, CA 94080, USA
    J Virol 81:7885-93. 2007
    In human immunodeficiency virus type 1 (HIV-1) subtype B, CXCR4 coreceptor use ranges from approximately 20% in early infection to approximately 50% in advanced disease. Coreceptor use by non-subtype B HIV is less well characterized...
  14. ncbi Involvement of SDF-1alpha/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Int J Cancer 122:91-9. 2008
    ..The aim of this study was to determine whether the stromal cell-derived factor-1alpha (SDF-1alpha)/CXCR4 axis is involved in the interaction of EOC cells with HPMCs in peritoneal metastasis...
  15. pmc Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis
    Lorena Hernandez
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Breast Cancer Res 13:R128. 2011
    CXCL12-CXCR4 signaling has been shown to play a role in breast cancer progression by enhancing tumor growth, angiogenesis, triggering cancer cell invasion in vitro, and guiding cancer cells to their sites of metastasis...
  16. ncbi The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
    E Oberlin
    Unite d Immunologie Virale, Institut Pasteur, Paris, France
    Nature 382:833-5. 1996
    A putative chemokine receptor that we previously cloned and termed LESTR has recently been shown to function as a co-receptor (termed fusin) for lymphocyte-tropic HIV-1 strains...
  17. pmc Dendritic cells preferentially transfer CXCR4-using human immunodeficiency virus type 1 variants to CD4+ T lymphocytes in trans
    Thijs van Montfort
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, Academic Medical Center of the University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Virol 82:7886-96. 2008
    ..target cell entry in the acute phase of infection, while later in disease progression the virus switches to the CXCR4 coreceptor in approximately 50% of patients...
  18. pmc Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma
    Yazan Alsayed
    University of Pittsburgh Cancer Institute, Division of Hematology Oncology, Department of Internal Medicine, University of Pittsburgh, PA, USA
    Blood 109:2708-17. 2007
    ..In this study, we sought to determine the effect of the chemokine SDF-1 (CXCL12) and its receptor CXCR4 on the migration and homing of MM cells...
  19. pmc Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5
    C B Davis
    Division of Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, NYU Medical Center 10016, USA
    J Exp Med 186:1793-8. 1997
    Infection with HIV-1 requires expression of CD4 and the chemokine receptors CXCR4 or CCR5 at the target cell surface...
  20. ncbi The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection
    F Cocchi
    Institute of Human Virology, University of Maryland Biotechnology Institute and School of Medicine, Baltimore, Maryland 21201, USA
    Nat Med 2:1244-7. 1996
    ..Consistent with this discrepancy, two distinct chemokine receptors, namely, CXCR4 (ref. 7) and CCR5 (ref...
  21. pmc CXCR7/CXCR4 heterodimer constitutively recruits beta-arrestin to enhance cell migration
    Fabien M Décaillot
    Laboratory of Molecular Biology and Biochemistry, Rockefeller University, New York, New York 10065, USA
    J Biol Chem 286:32188-97. 2011
    ..In this study, we have attempted to identify the functional significance of the heteromeric complex between CXCR4 and CXCR7 chemokine receptors...
  22. pmc The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice
    Tania N Petruzziello-Pellegrini
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 122:759-76. 2012
    ..Gene expression profiling of human microvascular endothelium treated with Stx implicated a role for activation of CXCR4 and CXCR7 by their shared cognate chemokine ligand (stromal cell-derived factor-1 [SDF-1]) in Stx-mediated ..
  23. doi Stromal-derived factor-1/CXCR4 signaling: indispensable role in homing and engraftment of hematopoietic stem cells in bone marrow
    Menka Sharma
    Stem Cell and Gene Therapy Research Group, Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Defense Research and Development Organization, New Delhi, India
    Stem Cells Dev 20:933-46. 2011
    ..Recent studies have highlighted the pivotal role of unique stromal-derived factor-1 (SDF-1)/CXCR4 signaling in the regulation of HSPC homing and subsequent engraftment...
  24. pmc Structural basis of the interaction between chemokine stromal cell-derived factor-1/CXCL12 and its G-protein-coupled receptor CXCR4
    Yutaka Kofuku
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Japan
    J Biol Chem 284:35240-50. 2009
    The chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) and its G-protein-coupled receptor (GPCR) CXCR4 play fundamental roles in many physiological processes, and CXCR4 is a drug target for various diseases such as cancer metastasis ..
  25. ncbi CXCR4 nuclear localization follows binding of its ligand SDF-1 and occurs in metastatic but not primary renal cell carcinoma
    Linhui Wang
    The Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, PR China
    Oncol Rep 22:1333-9. 2009
    Renal cell carcinoma (RCC) shows organ-specific metastasis. This may be attributed to the fact that the CXCR4 G protein coupled receptor on RCC cells mediates chemo-attraction toward stromal-derived factor (SDF)-1 secreted by target ..
  26. pmc HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells
    Christoph C Carter
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Host Microbe 9:223-34. 2011
    ..Furthermore, we establish that the capacity to use the chemokine receptor CXCR4 for entry determines whether a virus will enter multipotent versus differentiated progenitor cells...
  27. pmc HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3
    Jennifer Van Grol
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 5:e11733. 2010
    ..Neutralization of the upstream receptors VEGFR, beta-integrin or CXCR4, as well as of HIV-1 Tat or IL-10 restored autophagy in macrophage/monocytic cells exposed to HIV-1-infected cells...
  28. doi Moesin is required for HIV-1-induced CD4-CXCR4 interaction, F-actin redistribution, membrane fusion and viral infection in lymphocytes
    Marta Barrero-Villar
    Servicio de Inmunologia, Hospital Universitario de la Princesa, 28006 Madrid, Spain
    J Cell Sci 122:103-13. 2009
    ..regulates the initial attachment of viral particles to target cells through its association with CD4 and either CXCR4 or CCR5...
  29. ncbi Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4
    Federica Marchesi
    Department of Immunology and Cell Biology, Mario Negri Institute, Milan, Italy
    Cancer Res 64:8420-7. 2004
    ..cells from surgical samples of patients with pancreatic adenocarcinoma for expression of the chemokine receptor CXCR4. Six of 11 cell lines expressed detectable mRNA of CXCR4, with three cell lines (AsPC1, Capan1, and Hs766T) having ..
  30. ncbi The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
    C C Bleul
    The Center for Blood Research, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 382:829-33. 1996
    ..Laboratory-adapted and some T-cell-line-tropic (T-tropic) primary viruses use the orphan chemokine receptor LESTR/fusin (also known as fusin), whereas macrophage-tropic primary HIV-1 isolates use CCR-5 and CCR-3 (refs 7-11), ..
  31. doi A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells
    Tanja Nicole Hartmann
    The Weizmann Institute of Science, Rehovot, 76100, Israel
    J Leukoc Biol 84:1130-40. 2008
    ..The binding of CXCL12 to its receptor CXCR4 triggers Gi protein signals for motility and integrin activation in many cell types...
  32. pmc Cryptic nature of a conserved, CD4-inducible V3 loop neutralization epitope in the native envelope glycoprotein oligomer of CCR5-restricted, but not CXCR4-using, primary human immunodeficiency virus type 1 strains
    Paolo Lusso
    Unit of Human Virology, Department of Biological and Technological Research DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    J Virol 79:6957-68. 2005
    ..sequential interactions with two cellular receptor molecules, CD4 and a chemokine receptor, most commonly CCR5 or CXCR4. However, antibody accessibility to such regions is hindered by diverse protective mechanisms, including shielding ..
  33. ncbi Molecular and clinical epidemiology of CXCR4-using HIV-1 in a large population of antiretroviral-naive individuals
    Zabrina L Brumme
    BC Centre for Excellence in HIV AIDS, St Paul s Hospital, and Faculty of Medicine, University of British Columbia, Canada
    J Infect Dis 192:466-74. 2005
    We wished to characterize the epidemiological and clinical correlates of CXCR4-using human immunodeficiency virus type 1 (HIV-1) ("X4 variants") in a cross-sectional analysis of a large population of antiretroviral-naive individuals.
  34. pmc CXCR4 mediates the proliferation of glioblastoma progenitor cells
    Moneeb Ehtesham
    Department of Neurological Surgery, Vanderbilt University Medical Center, 21st Avenue and Garland Street, Nashville, TN 37232, USA
    Cancer Lett 274:305-12. 2009
    ..To this end, we now report that the cell surface chemokine receptor, CXCR4, a known mediator of cancer cell proliferation and invasion, is overexpressed in primary glioblastoma progenitor ..
  35. pmc Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor
    Peter J McCormick
    The Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e8102. 2009
    ..syndrome is a rare immunodeficiency syndrome linked to heterozygous mutations of the chemokine receptor CXCR4 resulting in truncations of its cytoplasmic tail...
  36. ncbi Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone
    Russell S Taichman
    Department of Periodontics, Prevention, and Geriatrics, and the Center for Biorestoration of Oral Health, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Cancer Res 62:1832-7. 2002
    ..stromal cell-derived factor-1 (SDF-1 or CXCL12; expressed by osteoblasts and endothelial cells) and its receptor (CXCR4) as key elements in these processes...
  37. pmc Membrane raft microdomains mediate lateral assemblies required for HIV-1 infection
    S Manes
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Madrid, Spain
    EMBO Rep 1:190-6. 2000
    ..These results indicate a general mechanism for HIV-1 envelope glycoprotein-mediated fusion by reorganization of membrane microdomains in the target cell, and offer new strategies for preventing HIV-1 infection...
  38. ncbi Morphological and molecular characterization of novel population of CXCR4+ SSEA-4+ Oct-4+ very small embryonic-like cells purified from human cord blood: preliminary report
    M Kucia
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 21:297-303. 2007
    Recently, we purified from adult murine bone marrow (BM) a population of CXCR4(+), Oct-4(+) SSEA-1(+), Sca-1(+) lin(-) CD45(-) very small embryonic-like (VSEL) stem cells and hypothesized that similar cells could be also present in human ..
  39. pmc The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network
    M Fareh
    INSERM U898 UNSA, Cellules Souches, Développement et Cancer, Faculte de Medecine, Av Valombrose, Nice, France
    Cell Death Differ 19:232-44. 2012
    ..the stemness signature, self-renewal, and cell infiltration within a host brain tissue, through inhibition of the CXCR4 pathway...
  40. pmc G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4
    Breann L Barker
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States
    Biochemistry 50:6933-41. 2011
    ..the phosphorylation of Ser-346 was required for proper agonist-induced internalization of the chemokine receptor CXCR4. Taken together, Hip has been identified as a novel substrate of GRK5 in vitro and in cells, and phosphorylation ..
  41. doi Characterization of CXCR4 expression in chondrosarcoma of bone
    Shuting Bai
    Department of Pathology, University of Alabama at Birmingham, 35233, USA
    Arch Pathol Lab Med 135:753-8. 2011
    Alterations in molecular elements derived from the CXC chemokine receptor 4 (CXCR4)/stromal-derived factor 1 (SDF-1) cytokine system have been found to strongly correlate with neoplastic progression leading to metastasis in a number of ..
  42. doi Nuclear expression of CXCR4 is associated with advanced colorectal cancer
    Shang Chiung Wang
    Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang Ming University, Taipei, Taiwan
    Int J Colorectal Dis 25:1185-91. 2010
    b>CXCR4 and its ligand, SDF-1alpha, play an important role in the targeted metastasis of colon cancer...
  43. doi IL-17 and tumour necrosis factor α combination induces a HIF-1α-dependent invasive phenotype in synoviocytes
    Arnaud Hot
    Department of Clinical Immunology and Rheumatology and Immunogenomics and Inflammation Research Unit, Hopital Edouard Herriot, University of Lyon 1, Lyon, France
    Ann Rheum Dis 71:1393-401. 2012
    ..To examine the effect of interleukin-17 (IL-17) on rheumatoid arthritis (RA) synoviocyte migration and invasiveness...
  44. ncbi Leukocyte elastase negatively regulates Stromal cell-derived factor-1 (SDF-1)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4
    Agustin Valenzuela-Fernandez
    Unite d Immunologie Virale, INSERM U485 de l Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 277:15677-89. 2002
    Activation of CXCR4 by the CXC chemokine stromal cell-derived factor-1 (SDF-1) requires interaction of the amino-terminal domains of both molecules...
  45. pmc Molecular switch for alternative conformations of the HIV-1 V3 region: implications for phenotype conversion
    Osnat Rosen
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 103:13950-5. 2006
    HIV-1 coreceptor usage plays a critical role in virus tropism and pathogenesis. A switch from CCR5- to CXCR4-using viruses occurs during the course of HIV-1 infection and correlates with subsequent disease progression...
  46. ncbi Mu-opioid modulation of HIV-1 coreceptor expression and HIV-1 replication
    Amber D Steele
    Department of Microbiology and Immunology, Center for Substance Abuse Research, and the Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Virology 309:99-107. 2003
    ..In the present report, we have investigated the effect of opioids on the expression of the major HIV-1 coreceptors CXCR4 and CCR5. For these studies we have focused on opiates which are ligands for the mu-opioid receptor...
  47. doi IGF-1-overexpressing mesenchymal stem cells accelerate bone marrow stem cell mobilization via paracrine activation of SDF-1alpha/CXCR4 signaling to promote myocardial repair
    Husnain Kh Haider
    Department of Pathology and Laboratory of Medicine, 231 Albert Sabin Way, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Circ Res 103:1300-8. 2008
    ..05). In conclusion, the strategy of IGF-1 transgene expression induced massive stem cell mobilization via SDF-1alpha signaling and culminated in extensive angiomyogenesis in the infarcted heart...
  48. ncbi Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1
    Ombretta Salvucci
    Experimental Transplantation and Immunology Branch and the Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 99:2703-11. 2002
    The chemokine stromal-derived factor-1 (SDF-1) and its unique receptor, CXCR4, are required for normal cardiovascular development, but a critical role for SDF-1 in postnatal vascular remodeling and the mechanisms underlying SDF-1/CXCR-4 ..
  49. ncbi Concomitant CXCR4 and CXCR7 expression predicts poor prognosis in renal cancer
    C D'Alterio
    Department of Oncological Immunology, National Cancer Institute, Naples, G Pascale, via Semmola, 80131 Naples, Italy
    Curr Cancer Drug Targets 10:772-81. 2010
    b>CXCR4 is a chemokine receptor implicated in the metastatic process...
  50. pmc The CXCR4 antagonist AMD3100 efficiently inhibits cell-surface-expressed human immunodeficiency virus type 1 envelope-induced apoptosis
    J Blanco
    Institut de Recerca de la SIDA Caixa, Laboratori de Retrovirologia, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Catalonia, Spain
    Antimicrob Agents Chemother 44:51-6. 2000
    ..is involved in both infected and uninfected cell death via its interaction with cellular receptors CD4 and CXCR4. We studied the effect of the blockade of CXCR4 receptors by the agonist stromal derived factor (SDF-1alpha) and ..
  51. doi B lymphocytes that migrate to tuberculous pleural fluid via the SDF-1/CXCR4 axis actively respond to antigens specific for Mycobacterium tuberculosis
    Lian Feng
    Institute of Immunology, Zhongshan School of Medicine, Key Laboratory of Tropical Disease Control Research of Ministry of Education, Sun Yat Sen University, Guangzhou, PR China
    Eur J Immunol 41:3261-9. 2011
    ..Furthermore, we found significantly higher expression of CXCR4 on B cells in the PF, and a chemotaxis assay showed that B cells in the PF were more responsive to stromal cell-..
  52. ncbi CXCR4, a potential predictive marker for docetaxel sensitivity in gastric cancer
    Li Xie
    The Comprehensive Cancer Center, of Drum Tower Hospital, affiliated to the Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing, PR China
    Anticancer Res 30:2209-16. 2010
    ..The aim of this study was to explore predictive genes involved in docetaxel sensitivity of gastric cancer...
  53. doi Mesenchymal stromal cells may enhance metastasis of neuroblastoma via SDF-1/CXCR4 and SDF-1/CXCR7 signaling
    Ming Ma
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, PR China
    Cancer Lett 312:1-10. 2011
    ..Neuroblastoma expressed both of the SDF-1 receptors CXCR4 and CXCR7...
  54. pmc Extreme genetic divergence is required for coreceptor switching in HIV-1 subtype C
    Mia Coetzer
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Acquir Immune Defic Syndr 56:9-15. 2011
    Coreceptor switching from CCR5 to CXCR4 is less common in subtype C HIV-1 infection than in subtype B for reasons that are unclear...
  55. doi Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus
    Andrew Wang
    University of Texas Southwestern Medical Center, Dallas, TX 75390 8884, USA
    Arthritis Rheum 62:3436-46. 2010
    b>CXCR4 is a chemokine with multiple effects on the immune system. In murine lupus models, we demonstrated that monocytes, neutrophils, and B cells overexpressed CXCR4 and that its ligand, CXCL12, was up-regulated in diseased kidneys...
  56. doi Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion
    Nami Miyanishi
    Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3 14 1 Hiyoshi, Kohoku Ku, Yokohama 223 8522, Japan
    Biochem Biophys Res Commun 403:154-9. 2010
    ..DHMEQ inhibited invasion in vitro and the expression of CXCL12 and CXCR4. We found that neutralizing antibody against CXCR4 or knockdown of CXCR4 suppressed the invasion...
  57. doi CXCR4 expression functionally discriminates centroblasts versus centrocytes within human germinal center B cells
    Gersende Caron
    Unité 917, Faculte de Medecine, Institut National de la Sante et de la Recherche Medicale, Universite Rennes 1, Rennes, France
    J Immunol 182:7595-602. 2009
    ..able for the first time to separate these two subpopulations based on the expression of the chemokine receptor CXCR4 allowing their characterization...
  58. pmc The deubiquitinating enzyme USP8 promotes trafficking and degradation of the chemokine receptor 4 at the sorting endosome
    Ilana Berlin
    Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 285:37895-908. 2010
    ..study explores an indirect role for USP8 in cargo trafficking through its regulation of the chemokine receptor 4 (CXCR4)...
  59. ncbi HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases
    C K Ullrich
    Divisions of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Blood 96:1438-42. 2000
    ..Recently, the alpha-chemokine receptor CXCR4 has been reported to mediate apoptosis in neuronal cells and in CD4(+) and CD8(+) T cells after its binding to HIV-..
  60. pmc Regulation of expression of stromal-derived factor-1 receptors: CXCR4 and CXCR7 in human rhabdomyosarcomas
    Maciej Tarnowski
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 South Floyd Street, Room 107, Louisville, KY 40202, USA
    Mol Cancer Res 8:1-14. 2010
    Rhabdomyosarcomas (RMS) express CXCR4 and CXCR7 receptors that bind prometastatic alpha-chemokine stromal-derived factor-1 (SDF-1)...
  61. ncbi Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4
    A Peled
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Science 283:845-8. 1999
    ..The chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR4 were found to be critical for murine bone marrow engraftment by human severe combined immunodeficient (SCID) ..
  62. ncbi The expression of CXCR4/CXCL12 in first-trimester human trophoblast cells
    Xia Wu
    Laboratory of Reproductive Immunology, Institute of Obstetrics and Gynecology, Fudan University, Shanghai 200011, China
    Biol Reprod 70:1877-85. 2004
    ..Among these receptors, CXCR4 was found highly transcribed...
  63. doi Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer
    Takuya Akashi
    Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Cancer Sci 99:539-42. 2008
    The chemokine receptor CXCR4 has been reported to be aberrantly expressed in human cancers and has also been shown to participate in the development of cancer metastasis...
  64. pmc Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling
    John M Busillo
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 285:7805-17. 2010
    The chemokine receptor CXCR4 is a widely expressed G protein-coupled receptor that has been implicated in a number of diseases including human immunodeficiency virus, cancer, and WHIM syndrome, with the latter two involving dysregulation ..
  65. pmc Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling
    Karl Balabanian
    INSERM U819, Paris, France
    J Clin Invest 118:1074-84. 2008
    ..infections, and myelokathexis (WHIM) syndrome, a rare immunodeficiency, and bearing a wild-type CXCR4 ORF (WHIM(WT)) display impaired CXCR4 internalization and desensitization upon exposure to CXCL12...
  66. pmc Methamphetamine enhances HIV-1 infectivity in monocyte derived dendritic cells
    Madhavan P N Nair
    Department of Immunology, College of Medicine, Florida International University, Miami, FL 33155, USA
    J Neuroimmune Pharmacol 4:129-39. 2009
    ..Meth induces increased HIV-1 infection in association with an increase in the HIV-1 coreceptors, CXCR4 and CCR5, and infection is mediated by downregulation of extracellular-regulated kinase (ERK2) and the ..
  67. pmc Regulation of the chemokine receptor CXCR4 by hypoxia
    Tiziana Schioppa
    Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    J Exp Med 198:1391-402. 2003
    ..Low oxygen concentration induces high expression of the CXCL12 receptor, CXC receptor 4 (CXCR4), in different cell types (monocytes, monocyte-derived macrophages, tumor-associated macrophages, endothelial ..
  68. ncbi Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradient
    Marcin Wysoczynski
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Blood 105:40-8. 2005
    ..was dependent on cholesterol content in the cell membrane and on the incorporation of the SDF-1 binding receptor CXCR4 and the small GTPase Rac-1 into membrane lipid rafts...
  69. ncbi Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
    Peter Staller
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nature 425:307-11. 2003
    ..For example, malignant breast cancer cells express the chemokine receptor CXCR4 and commonly metastasize to organs that are an abundant source of the CXCR4-specific ligand stromal cell-derived ..
  70. pmc Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway
    W Popik
    Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Virol 72:6406-13. 1998
    ..The activation of this signaling pathway requires functional CD4 receptors and is independent of binding to CXCR4. Binding of the natural ligand stromal cell-derived factor 1 (SDF-1) to CXCR4, which inhibits entry of T-cell-..
  71. ncbi Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia
    Elwin J C Rombouts
    Department of Hematology, Room Ee1391, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Blood 104:550-7. 2004
    ..These data suggest that the SDF-1/CXCR-4 axis may influence therapy responsiveness and defines unfavorable prognosis in AML...
  72. ncbi Possible role of stromal-cell-derived factor-1/CXCR4 signaling on lymph node metastasis of oral squamous cell carcinoma
    Daisuke Uchida
    Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, 3 18 15 Kuramoto, Tokushima 770 8504, Japan
    Exp Cell Res 290:289-302. 2003
    ..Of 13 kinds of chemokine receptors examined, only CXCR4 expression was up-regulated in HNt and B88 cells...
  73. doi Nuclear expression of CXCR4 in tumor cells of non-small cell lung cancer is correlated with lymph node metastasis
    Il Kang Na
    Department of Medicine III, Hematology, Oncology and Transfusion Medicine, Charite, Campus Benjamin Franklin, Berlin, D 12200 Berlin, Germany
    Hum Pathol 39:1751-5. 2008
    The stromal-derived factor 1alpha (CXCL12)/chemokine receptor CXCR4 system plays an important role in the metastatic process of a variety of cancers, with CXCR4 frequently expressed by tumor cells homing to CXCL12-rich compartments...
  74. ncbi Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers
    Yann Percherancier
    Department of Biochemistry, Universite de Montreal, Montreal H3C 3J7, Quebec, Canada
    J Biol Chem 280:9895-903. 2005
    ..Using a sensitive bioluminescence resonance energy transfer system, we investigated the formation of CXCR4 and CCR2 chemokine receptor dimers...
  75. ncbi Stromal cell-derived factor 1-mediated CXCR4 signaling in rat and human cortical neural progenitor cells
    Hui Peng
    Laboratory of Neurotoxicology, The Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha 68198 5215, USA
    J Neurosci Res 76:35-50. 2004
    Stromal cell-derived factor 1 (SDF-1) and the chemokine receptor CXCR4 are highly expressed in the nervous system...
  76. pmc Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo
    Shih Chieh Hung
    Center for Gene Therapy, Tulane University Health Science Center, New Orleans, Louisiana, United States of America
    PLoS ONE 2:e416. 2007
    ..Short-term exposure of MSCs to 1% oxygen increased expression of the chemokine receptors CX3CR1and CXCR4, both as mRNA and as protein...
  77. ncbi CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons
    J Hesselgesser
    Department of Immunology, Berlex Biosciences, Richmond, California 94804, USA
    Curr Biol 7:112-21. 1997
    ..We have shown previously that chemokine receptors including the interleukin-8 receptor B (CXCR2) and the Duffy blood group antigen are expressed on subsets of neurons in various regions of the adult nervous system...
  78. pmc Chemokine CXCL12 uses CXCR4 and a signaling core formed by bifunctional Akt, extracellular signal-regulated kinase (ERK)1/2, and mammalian target of rapamycin complex 1 (mTORC1) proteins to control chemotaxis and survival simultaneously in mature dendriti
    Cristina Delgado-Martín
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, 28040 Madrid, Spain
    J Biol Chem 286:37222-36. 2011
    ..As maDCs are exposed to chemokine CXCL12 (receptors CXCR4 and CXCR7) during their migration, its functions are amenable to be regulated by this ligand...
  79. pmc Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4
    Lucile Espert
    Laboratoire Infections Retrovirales et Signalisation Cellulaire, CNRS UMR 5121, Institut de Biologie, Montpellier, France
    J Clin Invest 116:2161-72. 2006
    ..cells that express Env induced autophagy and accumulation of Beclin 1 in uninfected CD4+ T lymphocytes via CXCR4. The same phenomena occurred in a T cell line and in transfected HEK...
  80. pmc Unique ligand binding sites on CXCR4 probed by a chemical biology approach: implications for the design of selective human immunodeficiency virus type 1 inhibitors
    Won Tak Choi
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Virol 79:15398-404. 2005
    The chemokine receptor CXCR4 plays an important role as the receptor for the normal physiological function of stromal cell-derived factor 1alpha (SDF-1alpha) and the coreceptor for the entry of human immunodeficiency virus type 1 (HIV-1) ..
  81. pmc Accurate and efficient gp120 V3 loop structure based models for the determination of HIV-1 co-receptor usage
    Majid Masso
    Laboratory for Structural Bioinformatics, Department of Bioinformatics and Computational Biology, George Mason University, 10900 University Blvd, MS 5B3, Manassas, VA 20110, USA
    BMC Bioinformatics 11:494. 2010
    ..both the CD4 receptor, which binds the viral envelope glycoprotein gp120, as well as either the CCR5 (R5) or CXCR4 (X4) co-receptors, which interact primarily with the third hypervariable loop (V3 loop) of gp120...
  82. doi Stromal cell-derived factor-1 but not its receptor, CXCR4, gene variants increase susceptibility and pathological development of hepatocellular carcinoma
    Chi Chung Chang
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Clin Chem Lab Med 47:412-8. 2009
    ..Because the stromal cell-derived factor-1 (SDF-1) and its receptor, CXCR4, have been reported to play important roles in tumor cell proliferation, angiogenesis, and metastasis of HCC, the ..
  83. pmc Env sequence determinants in CXCR4-using human immunodeficiency virus type-1 subtype C
    Nina H Lin
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA
    Virology 433:296-307. 2012
    HIV-1 subtype C (HIV-1C) CXCR4-using virus is isolated infrequently and is poorly characterized. Understanding HIV-1C env characteristics has implications for the clinical use of antiretrovirals that target viral entry...
  84. pmc Evolution of CCR5 use before and during coreceptor switching
    Mia Coetzer
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Virol 82:11758-66. 2008
    ..individuals or more, env evolution leads to expansion of the use of entry coreceptor from CCR5 alone to CCR5 and CXCR4. The stochastic nature of this coreceptor switch is not well explained by host selective forces that should be ..
  85. doi CXCR4 promotes oral squamous cell carcinoma migration and invasion through inducing expression of MMP-9 and MMP-13 via the ERK signaling pathway
    Tao Yu
    Department of Head and Neck Oncology Surgery, West China College of Stomatology, Sichuan University, No 14, Sec 3, Renminnan Road, Chengdu Sichuan 610041, People s Republic of China
    Mol Cancer Res 9:161-72. 2011
    ..Although the chemokine receptor CXCR4 and its ligand, stromal cell-derived factor-1α, have been found to play an important role in tumor invasion, its ..
  86. ncbi CXCR4 expression is associated with lymph-node metastasis of oral squamous cell carcinoma
    Tohru Ishikawa
    Department of Oral and Maxillofacial Surgery, Ehime University School of Medicine, Toon, Ehime 791 0295, Japan
    Int J Oncol 28:61-6. 2006
    ..CXCR3 mRNA and protein were expressed in all the OSCC cell lines examined, while CXCR4 mRNA and protein were expressed only in HSC2, HSC3, and Ca9-22 cells...
  87. ncbi The importance of the CXCL12-CXCR4 chemokine ligand-receptor interaction in prostate cancer metastasis
    Manit Arya
    Prostate Cancer Research Centre, Institute of Urology, University College London, UK
    J Exp Ther Oncol 4:291-303. 2004
    ..Our aim was to study the role of the CXCL12:CXCR4 chemokine ligand:receptor complex in determining the organ-specific metastasis of prostate cancer.
  88. pmc Coreceptor tropism can be influenced by amino acid substitutions in the gp41 transmembrane subunit of human immunodeficiency virus type 1 envelope protein
    Wei Huang
    Monogram Biosciences, 345 Oyster Point Blvd, South San Francisco, CA 94080, USA
    J Virol 82:5584-93. 2008
    ..The introduction of distinct V3 sequences from CXCR4-using clones into an R5-tropic env backbone conferred the inefficient use of CXCR4 in some but not all cases...
  89. ncbi Surface expression of neutrophil CXCR4 is down-modulated by bacterial endotoxin
    Hyun Kyung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Int J Hematol 85:390-6. 2007
    The chemokine receptor CXCR4 and its unique ligand, stromal-derived factor 1 (SDF-1), play critical roles in the retention of hematopoietic cells within bone marrow and in their mobilization into the circulation...
  90. pmc CXCL12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in bone
    Sreenivasa R Chinni
    Department of Urology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Mol Cancer Res 6:446-57. 2008
    ..Previously, we showed that binding of the chemokine CXCL12 to its receptor CXCR4 mediated signaling events resulting in matrix metalloproteinase-9 expression in prostate cancer bone metastasis...
  91. pmc Dynamic regulation of ROCK in tumor cells controls CXCR4-driven adhesion events
    Amanda P Struckhoff
    Department of Oral Biology, LSU Health Sciences Center, New Orleans, LA 70112, USA
    J Cell Sci 123:401-12. 2010
    b>CXCR4 is a chemokine receptor often found aberrantly expressed on metastatic tumor cells. To investigate CXCR4 signaling in tumor cell adhesion, we stably overexpressed CXCR4 in MCF7 breast tumor cells...
  92. ncbi Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis
    Ilona Kryczek
    Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109 0669, USA
    Am J Physiol Cell Physiol 292:C987-95. 2007
    ..Therefore, it stands to reason that the CXCL12/CXCR4 pathway is an important target for the development of novel anti-cancer therapies...
  93. pmc The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction
    Deepali Bhandari
    Program in Molecular Biology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
    Mol Biol Cell 20:1324-39. 2009
    ..ligase atrophin interacting protein 4 (AIP4) mediates ubiquitination and down-regulation of the chemokine receptor CXCR4. AIP4 belongs to the Nedd4-like homologous to E6-AP carboxy terminus domain family of E3 ubiquitin ligases, which ..
  94. ncbi Elevated levels of chemokine receptor CXCR4 in HER-2 negative breast cancer specimens predict recurrence
    Neal T Holm
    Department of Surgery, Louisiana State University Health Sciences Center in Shreveport, Shreveport, Louisiana, USA
    J Surg Res 141:53-9. 2007
    b>CXCR4 is a chemokine receptor that has recently been implicated to play a pivotal role in breast cancer growth and metastasis...
  95. ncbi The chemokine receptor CXCR4 is regulated by DNA methylation in pancreatic cancer
    Norihiro Sato
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Cancer Biol Ther 4:70-6. 2005
    Despite the biological and clinical importance of the interaction between the chemokine receptor CXCR4 and its ligand CXCL12 (SDF-1alpha) in human cancers, little is known about transcriptional regulation of the CXCR4 gene...
  96. doi SDF-1alpha G801A polymorphism predicts lymph node metastasis in stage T3 colorectal cancer
    Shih Ching Chang
    Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang Ming University, Taipei, Taiwan
    Ann Surg Oncol 16:2323-30. 2009
    The SDF-1/CXCR4 axis plays an important role in cancer metastasis. SDF1alpha genetic polymorphisms, including SDF1alpha-G801A, have been associated with increased cancer risk and may be predictive of distant metastasis...
  97. doi Chemokine receptor CXCR4 enhances proliferation in pancreatic cancer cells through AKT and ERK dependent pathways
    Xiaoming Shen
    City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, USA
    Pancreas 39:81-7. 2010
    We previously detected CXCR4 expression in pancreatic intraepithelial neoplasia (PanIN) tissues and demonstrated CXCR4-enhanced proliferation of PanIN cells...
  98. ncbi The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract
    K Tachibana
    Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Izumi, Japan
    Nature 393:591-4. 1998
    ..The cell-surface receptor CXCR4 is a seven-transmembrane-spanning, G-protein-coupled receptor for the CXC chemokine PBSF/SDF-1 (for pre-B-cell ..
  99. pmc Expression of Nef from unintegrated HIV-1 DNA downregulates cell surface CXCR4 and CCR5 on T-lymphocytes
    Richard D Sloan
    McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada
    Retrovirology 7:44. 2010
    ..to determine whether Nef expressed from unintegrated DNA was also able to downregulate the chemokine coreceptors CXCR4 and CCR5...
  100. pmc SDF1 gene variation is associated with circulating SDF1alpha level and endothelial progenitor cell number: the Bruneck Study
    Qingzhong Xiao
    Cardiovascular Division, King s College London BHF Centre, London, UK
    PLoS ONE 3:e4061. 2008
    Stromal cell-derived factor-1 (SDF1) and its receptor CXC chemokine receptor 4 (CXCR4) play a critical role in progenitor cell homing, mobilization and differentiation...
  101. doi Clinical significance of CXC chemokine receptor-4 and c-Met in childhood rhabdomyosarcoma
    Francesca Diomedi-Camassei
    Division of Pathology, Bambino Gesu Children s Hospital, Rome, Italy
    Clin Cancer Res 14:4119-27. 2008
    The CXC chemokine receptor-4 (CXCR4)/stromal-derived factor-1 and c-Met/hepatocyte growth factor axes promote the metastatic potential of rhabdomyosarcoma cell lines in experimental models, but no data are available on their role in ..

Research Grants80

  1. HIV, Chemokine Receptors, and Vascular Smooth Muscle
    ALISON SCHECTER; Fiscal Year: 2007
    ..SMC), the major cellular components of the vessel wall, possess the functional chemokine receptors, CCR5, and CXCR4. Engagement of these receptors results in a marked induction of tissue factor (TF) activity...
  2. HIV, Chemokine Receptors, and Vascular Smooth Muscle
    ALISON SCHECTER; Fiscal Year: 2003
    ..SMC), the major cellular components of the vessel wall, possess the functional chemokine receptors, CCR5, and CXCR4. Engagement of these receptors results in a marked induction of tissue factor (TF) activity...
  3. HIV, Chemokine Receptors, and Vascular Smooth
    ALISON SCHECTER; Fiscal Year: 2004
    ..SMC), the major cellular components of the vessel wall, possess the functional chemokine receptors, CCR5, and CXCR4. Engagement of these receptors results in a marked induction of tissue factor (TF) activity...
  4. HIV, Chemokine Receptors, and Vascular Smooth
    ALISON SCHECTER; Fiscal Year: 2006
    ..SMC), the major cellular components of the vessel wall, possess the functional chemokine receptors, CCR5, and CXCR4. Engagement of these receptors results in a marked induction of tissue factor (TF) activity...
  5. HIV, Chemokine Receptors, and Vascular Smooth
    ALISON SCHECTER; Fiscal Year: 2005
    ..SMC), the major cellular components of the vessel wall, possess the functional chemokine receptors, CCR5, and CXCR4. Engagement of these receptors results in a marked induction of tissue factor (TF) activity...
  6. Cellular and molecular mechanisms of gp120 neurotoxicity
    Italo Mocchetti; Fiscal Year: 2011
    ..Preliminary evidence has shown that the chemokine receptor CXCR4 promotes endocytosis of T-tropic gp120 into neurons...
  7. Oncolytic Viruses with Therapeutic Genes in the Treatment of Breast Cancer
    DANUTA B KOZBOR; Fiscal Year: 2013
    ..our preliminary results demonstrated that oncolytic vaccinia virus (OVV) expressing an antagonist of the CXCR4 receptor for CXCL12 chemokine (OVV- CXCR4-A-Fc) was more effective in inhibiting growth of triple-negative (TN) ..
  8. Stem cells in liver regeneration: fusion or plasticity
    Bryon E Petersen; Fiscal Year: 2013
    ..aim 2: We hypothesize that activation of the MEK and PI3K signal transduction pathways following SDF-1 binding to CXCR4 receptor on the cell membrane enhances both proliferation and migration of liver oval cells...
  9. Imaging and targeting metastatic disease
    Sridhar Nimmagadda; Fiscal Year: 2013
    ..or CXCL12) is secreted by stroma in potential metastatic sites and attracts circulating chemokine receptor 4 (CXCR4) expressing cells...
  10. BICARBONATE TRANSPORT BY THE MATURING RENAL TUBULE
    George J Schwartz; Fiscal Year: 2013
    ..Aim 3 will determine the role of the SDF-1/CXCR4 pathway as an early response in the adaptation to acidosis...
  11. REGULATION OF HIV1 CORECEPTORS CXCR4
    Haribabu Bodduluri; Fiscal Year: 2001
    ..Recently, chemokine receptors CCR5 or CXCR4 were identified as essential co-receptors for the entry of human immunodeficiency virus HIV-1 into CD4 positive ..
  12. REGULATION OF HIV1 CORECEPTORS CXCR4
    Haribabu Bodduluri; Fiscal Year: 1999
    ..Recently, chemokine receptors CCR5 or CXCR4 were identified as essential co-receptors for the entry of human immunodeficiency virus HIV-1 into CD4 positive ..
  13. REGULATION OF HIV1 CORECEPTORS CXCR4
    Haribabu Bodduluri; Fiscal Year: 2002
    ..Recently, chemokine receptors CCR5 or CXCR4 were identified as essential co-receptors for the entry of human immunodeficiency virus HIV-1 into CD4 positive ..
  14. REGULATION OF HIV1 CORECEPTORS CXCR4
    Haribabu Bodduluri; Fiscal Year: 2000
    ..Recently, chemokine receptors CCR5 or CXCR4 were identified as essential co-receptors for the entry of human immunodeficiency virus HIV-1 into CD4 positive ..
  15. REGULATION OF HIV1 CORECEPTORS CXCR4
    Haribabu Bodduluri; Fiscal Year: 2000
    ..Recently, chemokine receptors CCR5 or CXCR4 were identified as essential co-receptors for the entry of human immunodeficiency virus HIV-1 into CD4 positive ..
  16. Targeting the CXCL12/CXCR4 Axis towards the Therapy of Metastatic Cancers
    Rongshi Li; Fiscal Year: 2013
    ..project is to discover novel chemical probes that are capable of potently and selectively disrupting the CXCL12/CXCR4 protein-protein binding...
  17. Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
    ALEXANDRA HOWELL; Fiscal Year: 2009
    ..However, APC also express CD4, CCR5, and CXCR4 receptors and can become productively infected with HIV-1...
  18. Matrix Metalloproteinases and Spinal Cord Injury
    Linda Noble; Fiscal Year: 2009
    ..Aims 2 and 3 will examine synergism between chemokine stromal-derived factor-1 (SDF-1), its receptor, CXCR4, and MMP-9 in the homing and transendothelial migration of BMDMs to the injured cord...
  19. Matrix Metalloproteinases and Spinal Cord Injury
    Linda J Noble; Fiscal Year: 2010
    ..Aims 2 and 3 will examine synergism between chemokine stromal-derived factor-1 (SDF-1), its receptor, CXCR4, and MMP-9 in the homing and transendothelial migration of BMDMs to the injured cord...
  20. Structural Basis for Chemokine Function
    Brian F Volkman; Fiscal Year: 2013
    ..Stromal cell-derived factor-1 (SDF1/ CXCL12) and its cognate receptors CXCR4 and CXCR7 are essential for life and play unique roles in human development, HIV infection, stem cell homing and ..
  21. Structural Basis for Chemokine Function
    Brian F Volkman; Fiscal Year: 2010
    ..Stromal cell-derived factor-1 (SDF1/ CXCL12) and its cognate receptors CXCR4 and CXCR7 are essential for life and play unique roles in human development, HIV infection, stem cell homing and ..
  22. Pathogenesis and Therapy of HIV-Related Neuropathic Pain
    Shuanglin Hao; Fiscal Year: 2009
    ..Studies in vitro have shown that the coat glycoprotein gp120 of HIV, acting through the CXCR4 receptor can: 1) stimulate Schwann cells to release RANTES and then induce release of tumor necrosis factor alpha (..
  23. Pathogenesis and Therapy of HIV-Related Neuropathic Pain
    Shuanglin Hao; Fiscal Year: 2010
    ..Studies in vitro have shown that the coat glycoprotein gp120 of HIV, acting through the CXCR4 receptor can: 1) stimulate Schwann cells to release RANTES and then induce release of tumor necrosis factor alpha (..
  24. Gp120 in the brain and opioid medications: Functional interactions
    Khalid Benamar; Fiscal Year: 2010
    ..brain levels of Stromal cell-Derived growth Factor-1alpha (SDF-1 alpha/CXCL12), the ligand of the HIV co-receptor CXCR4 (a condition that occurs with neuroinflammatory diseases, including HIV encephalitis), diminish the analgesic ..
  25. Biliary Epithelial Cell-derived SDF-1a in Hepatic Fibrogenesis and Inflammation
    Yedidya Saiman; Fiscal Year: 2013
    ..metastasis, angiogenesis and migration of lymphocytes to sites of injury through interactions with its receptor, CXCR4. Hepatic stellate cell (HSC) activation is central feature of fibrosis in all forms of chronic liver injury and we ..
  26. CXCR4 Expression and Function in Astrocytes
    ETTY BENVENISTE; Fiscal Year: 2003
    ..Astrocytes express receptors for numerous chemokines, including CXCR4. CXCR4 is the exclusive receptor for the chemokine stromal cell-derived factor-I (SDF-l)...
  27. CXCR4 Expression and Function in Astrocytes
    ETTY BENVENISTE; Fiscal Year: 2004
    ..Astrocytes express receptors for numerous chemokines, including CXCR4. CXCR4 is the exclusive receptor for the chemokine stromal cell-derived factor-I (SDF-l)...
  28. CXCR4 Expression and Function in Astrocytes
    ETTY BENVENISTE; Fiscal Year: 2001
    ..Astrocytes express receptors for numerous chemokines, including CXCR4. CXCR4 is the exclusive receptor for the chemokine stromal cell-derived factor-I (SDF-l)...
  29. CXCR4 Expression and Function in Astrocytes
    ETTY BENVENISTE; Fiscal Year: 2002
    ..Astrocytes express receptors for numerous chemokines, including CXCR4. CXCR4 is the exclusive receptor for the chemokine stromal cell-derived factor-I (SDF-l)...
  30. Role of Slit in CXCR4-Mediated Breast Cancer Metastasis
    Ramesh Ganju; Fiscal Year: 2009
    The chemokine receptor CXCR4 and its ligand CXCL12 play a critical role in breast cancer metastasis...
  31. Role of Slit in CXCR4-Mediated Breast Cancer Metastasis
    Ramesh Ganju; Fiscal Year: 2007
    The chemokine receptor CXCR4 and its ligand CXCL12 play a critical role in breast cancer metastasis...
  32. Role of Slit in CXCR4-Mediated Breast Cancer Metastasis
    Ramesh Ganju; Fiscal Year: 2005
    The chemokine receptor CXCR4 and its ligand CXCL12 play a critical role in breast cancer metastasis...
  33. Role of Slit in CXCR4-Mediated Breast Cancer Metastasis
    Ramesh Ganju; Fiscal Year: 2006
    The chemokine receptor CXCR4 and its ligand CXCL12 play a critical role in breast cancer metastasis...
  34. Role of Slit in CXCR4-Mediated Breast Cancer Metastasis
    Ramesh Ganju; Fiscal Year: 2007
    The chemokine receptor CXCR4 and its ligand CXCL12 play a critical role in breast cancer metastasis...
  35. The Function and Regulation of Trefoil Factor Family 2 (TFF2)
    Timothy Wang; Fiscal Year: 2009
    ..In addition, we have made the unexpected observation that TFF2 is a natural ligand for the CXCR4 receptor, a G-protein coupled receptor and the primary receptor for SDF-1...
  36. The Function and Regulation of Trefoil Factor Family 2 (TFF2)
    TIMOTHY CRAGIN WANG; Fiscal Year: 2010
    ..In addition, we have made the unexpected observation that TFF2 is a natural ligand for the CXCR4 receptor, a G-protein coupled receptor and the primary receptor for SDF-1...
  37. CXCL12/CXCR4 Signaling - A Novel Target for Pancreatic Intraepithelial Neoplasia
    Joseph Kim; Fiscal Year: 2010
    ..Recently, our laboratory was the first to identify a potential role for chemokine receptor CXCR4 in the growth and proliferation of PanIN...
  38. CXCL12/CXCR4 Signaling - A Novel Target for Pancreatic Intraepithelial Neoplasia
    Joseph Kim; Fiscal Year: 2009
    ..Recently, our laboratory was the first to identify a potential role for chemokine receptor CXCR4 in the growth and proliferation of PanIN...
  39. Stabilization of CXCR4 and its complexes for high resolution structural studies
    QINGHAI contact ZHANG; Fiscal Year: 2010
    Experimentally determining the 3-D structure of the G protein-coupled receptor (GPCR), CXCR4 and its complexes, the overall goal of the proposed study, is critical in developing a deeper understanding of its role in HIV viral entry and ..
  40. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2006
    ..may play a crucial role in directing to the BM the RMS cells that express the receptor for SDF-1, CXCR4. To investigate the mechanisms operating in the metastasis of RMS and develop a new therapeutic approach to ..
  41. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2007
    ..may play a crucial role in directing to the BM the RMS cells that express the receptor for SDF-1, CXCR4. To investigate the mechanisms operating in the metastasis of RMS and develop a new therapeutic approach to ..
  42. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2009
    ..may play a crucial role in directing to the BM the RMS cells that express the receptor for SDF-1, CXCR4. To investigate the mechanisms operating in the metastasis of RMS and develop a new therapeutic approach to ..
  43. Stabilization of CXCR4 and its complexes for high resolution structural studies
    Qinghai Zhang; Fiscal Year: 2009
    Experimentally determining the 3-D structure of the G protein-coupled receptor (GPCR), CXCR4 and its complexes, the overall goal of the proposed study, is critical in developing a deeper understanding of its role in HIV viral entry and ..
  44. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2005
    ..may play a crucial role in directing to the BM the RMS cells that express the receptor for SDF-1, CXCR4. To investigate the mechanisms operating in the metastasis of RMS and develop a new therapeutic approach to ..
  45. HIV-1 Infection and the Peripheral Nervous System
    Richard Miller; Fiscal Year: 2009
    ..Under normal conditions CXCR4, the receptors for the chemokine SDF-1/CXCL12, are expressed by DRG neurons and glia...
  46. HIV-1 Infection and the Peripheral Nervous System
    Richard J Miller; Fiscal Year: 2010
    ..Under normal conditions CXCR4, the receptors for the chemokine SDF-1/CXCL12, are expressed by DRG neurons and glia...
  47. Imaging and targeting metastatic disease
    Sridhar Nimmagadda; Fiscal Year: 2012
    ..or CXCL12) is secreted by stroma in potential metastatic sites and attracts circulating chemokine receptor 4 (CXCR4) expressing cells...
  48. SDF-1A AND MIP-II INTERACTIONS WITH CHEMOKINE RECEPTORS
    Elias Lolis; Fiscal Year: 2002
    ..One chemokine, stromal cell-derived factor SDF-1a is the natural agonist for the receptor CXCR4. The CXCR4 receptor has also been identified as the co-receptor for T-tropic, syncytium inducing strains of HIV-1...
  49. SDF-1A AND MIP-II INTERACTIONS WITH CHEMOKINE RECEPTORS
    Elias Lolis; Fiscal Year: 2000
    ..One chemokine, stromal cell-derived factor SDF-1a is the natural agonist for the receptor CXCR4. The CXCR4 receptor has also been identified as the co-receptor for T-tropic, syncytium inducing strains of HIV-1...
  50. SDF-1A AND MIP-II INTERACTIONS WITH CHEMOKINE RECEPTORS
    Elias Lolis; Fiscal Year: 2001
    ..One chemokine, stromal cell-derived factor SDF-1a is the natural agonist for the receptor CXCR4. The CXCR4 receptor has also been identified as the co-receptor for T-tropic, syncytium inducing strains of HIV-1...
  51. SDF-1A AND MIP-II INTERACTIONS WITH CHEMOKINE RECEPTORS
    Elias Lolis; Fiscal Year: 1999
    ..One chemokine, stromal cell-derived factor SDF-1a is the natural agonist for the receptor CXCR4. The CXCR4 receptor has also been identified as the co-receptor for T-tropic, syncytium inducing strains of HIV-1...
  52. CHEMOKINE RECEPTORS AND HIV MEDIATED SIGNALING
    Waldemar Popik; Fiscal Year: 1999
    ..CD4 receptors, the question arises whether the binding of HIV-1 virions to the newly described HIV-1 coreceptor, CXCR4 participates or contributes to this signaling...
  53. CHEMOKINE RECEPTORS AND HIV MEDIATED SIGNALING
    Waldemar Popik; Fiscal Year: 2001
    ..CD4 receptors, the question arises whether the binding of HIV-1 virions to the newly described HIV-1 coreceptor, CXCR4 participates or contributes to this signaling...
  54. CHEMOKINE RECEPTORS AND HIV MEDIATED SIGNALING
    Waldemar Popik; Fiscal Year: 2000
    ..CD4 receptors, the question arises whether the binding of HIV-1 virions to the newly described HIV-1 coreceptor, CXCR4 participates or contributes to this signaling...
  55. Transnasal Delivery of Chemokine Analogs in mouse NeuroAIDS Models
    Stuart A Lipton; Fiscal Year: 2013
    ..As potential treatment, we and our collaborators have synthesized new peptide inhibitors of chemokine receptors (CXCR4 and CCR5, which are co-receptors for HIV/gp120), and found that these novel synthetically and modularly modified (..
  56. HIV-1 gp120 Mediated Chemotaxis of Blood Cells
    Ramesh Ganju; Fiscal Year: 2004
    DESCRIPTION: (provided by applicant) Chemokine receptors CXCR4 and CCR5 play critical roles in H1V infection...
  57. HIV-1 gp120 Mediated Chemotaxis of Blood Cells
    Ramesh Ganju; Fiscal Year: 2003
    DESCRIPTION: (provided by applicant) Chemokine receptors CXCR4 and CCR5 play critical roles in H1V infection...
  58. HIV-1 gp120 Mediated Chemotaxis of Blood Cells
    Ramesh Ganju; Fiscal Year: 2001
    DESCRIPTION: (provided by applicant) Chemokine receptors CXCR4 and CCR5 play critical roles in H1V infection...
  59. HIV-1 gp120 Mediated Chemotaxis of Blood Cells
    Ramesh Ganju; Fiscal Year: 2002
    DESCRIPTION: (provided by applicant) Chemokine receptors CXCR4 and CCR5 play critical roles in H1V infection...
  60. HIV-1 gp120 Mediated Chemotaxis of Blood Cells
    Ramesh Ganju; Fiscal Year: 2005
    DESCRIPTION: (provided by applicant) Chemokine receptors CXCR4 and CCR5 play critical roles in H1V infection...
  61. Natural IgM antilymphocyte autoantibodies inhibit HIV-1
    PETER LOBO; Fiscal Year: 2003
    ..The latency period is determined by host factors that control viral infectivity. Chemokine receptors (CCR5 and CXCR4) serve as co-receptors for HIV-1 entry into cells...
  62. Natural IgM antilymphocyte autoantibodies inhibit HIV-1
    PETER LOBO; Fiscal Year: 2002
    ..The latency period is determined by host factors that control viral infectivity. Chemokine receptors (CCR5 and CXCR4) serve as co-receptors for HIV-1 entry into cells...
  63. Chemokines and Macrophages in HIV Neuronal Apoptosis
    Stuart Lipton; Fiscal Year: 2001
    ..Microglia, astrocytes and neurons express co-receptors for HIV-1, namely the chemokine receptors CCR5 and CXCR4. Using chemokine receptor knock-out mice, the objectives of this application are to further elucidate the role of ..
  64. Chemokines and Macrophages in HIV Neuronal Apoptosis
    Stuart Lipton; Fiscal Year: 2002
    ..Microglia, astrocytes and neurons express co-receptors for HIV-1, namely the chemokine receptors CCR5 and CXCR4. Using chemokine receptor knock-out mice, the objectives of this application are to further elucidate the role of ..
  65. Chemokines and Macrophages in HIV Neuronal Apoptosis
    Stuart Lipton; Fiscal Year: 2003
    ..Microglia, astrocytes and neurons express co-receptors for HIV-1, namely the chemokine receptors CCR5 and CXCR4. Using chemokine receptor knock-out mice, the objectives of this application are to further elucidate the role of ..
  66. Molecular Imaging of Metastatic Potential in SCCHN by Targeting VLA-4 and CXCR4
    Carolyn J Anderson; Fiscal Year: 2013
    ..imaging agents to quantify integrin (also called very late antigen 4, or VLA-4) and CXC chemokine receptor 4 (CXCR4) levels, both of which play a putative role in the metastasis of head and neck cancer to lymph nodes...
  67. CCR5 & CXCR4 Antagonist & Agonist Binding Site Structure
    EDWARD DRATZ; Fiscal Year: 2009
    ..is a complex process that requires binding of the HIV envelope protein gp120 to a cellular co-receptor (CCR5 or CXCR4)...
  68. CCR5 & CXCR4 Antagonist & Agonist Binding Site Structure
    EDWARD DRATZ; Fiscal Year: 2007
    ..is a complex process that requires binding of the HIV envelope protein gp120 to a cellular co-receptor (CCR5 or CXCR4)...
  69. CCR5 & CXCR4 Antagonist & Agonist Binding Site Structure
    EDWARD DRATZ; Fiscal Year: 2005
    ..is a complex process that requires binding of the HIV envelope protein gp120 to a cellular co-receptor (CCR5 or CXCR4)...
  70. CD8+ T CELL APOPTOSIS IN HIV INFECTION
    Georges Herbein; Fiscal Year: 2000
    ..Following interaction of CXCR4 with the HIV envelope gp120, tumor necrosis factor receptor 2 (TNFR2) is up-regulated on Cd8+ T cells and tumor ..
  71. CCR5 and CXCR4 Binding Chemokines and Oral HIV Infection
    Grace John Stewart; Fiscal Year: 2004
    ..Chemokines, the natural ligands for the HIV-1 co-receptors CCR5 and CXCR4, are potential candidates...
  72. CCR5 and CXCR4 Binding Chemokines and Oral HIV Infection
    Grace John Stewart; Fiscal Year: 2003
    ..Chemokines, the natural ligands for the HIV-1 co-receptors CCR5 and CXCR4, are potential candidates...
  73. CCR5 and CXCR4 Binding Chemokines and Oral HIV Infection
    Grace John Stewart; Fiscal Year: 2005
    ..Chemokines, the natural ligands for the HIV-1 co-receptors CCR5 and CXCR4, are potential candidates...
  74. CCR5 and CXCR4 Binding Chemokines and Oral HIV Infection
    Grace John Stewart; Fiscal Year: 2002
    ..Chemokines, the natural ligands for the HIV-1 co-receptors CCR5 and CXCR4, are potential candidates...
  75. Neurotrophic factors and HIV-mediated neuronal injury
    Italo Mocchetti; Fiscal Year: 2007
    ..that gp120 causes neuronal cell death by activating an apoptotic pathway through the chemokine receptor CXCR4. Interestingly, the neurotrophin brain-derived neurotrophic factor (BDNF) prevents gp120-mediated neurotoxicity in ..
  76. Neurotrophic factors and HIV-mediated neuronal injury
    Italo Mocchetti; Fiscal Year: 2007
    ..that gp120 causes neuronal cell death by activating an apoptotic pathway through the chemokine receptor CXCR4. Interestingly, the neurotrophin brain-derived neurotrophic factor (BDNF) prevents gp120-mediated neurotoxicity in ..
  77. Neurotrophic factors and HIV-mediated neuronal injury
    Italo Mocchetti; Fiscal Year: 2005
    ..that gp120 causes neuronal cell death by activating an apoptotic pathway through the chemokine receptor CXCR4. Interestingly, the neurotrophin brain-derived neurotrophic factor (BDNF) prevents gp120-mediated neurotoxicity in ..
  78. Neurotrophic factors and HIV-mediated neuronal injury
    Italo Mocchetti; Fiscal Year: 2006
    ..that gp120 causes neuronal cell death by activating an apoptotic pathway through the chemokine receptor CXCR4. Interestingly, the neurotrophin brain-derived neurotrophic factor (BDNF) prevents gp120-mediated neurotoxicity in ..
  79. CCR5 & CXCR4 Antagonist & Agonist Binding Site Structure
    EDWARD DRATZ; Fiscal Year: 2007
    ..is a complex process that requires binding of the HIV envelope protein gp120 to a cellular co-receptor (CCR5 or CXCR4)...
  80. CCR5 & CXCR4 Antagonist & Agonist Binding Site Structure
    EDWARD DRATZ; Fiscal Year: 2006
    ..is a complex process that requires binding of the HIV envelope protein gp120 to a cellular co-receptor (CCR5 or CXCR4)...