CXCR3

Summary

Gene Symbol: CXCR3
Description: C-X-C motif chemokine receptor 3
Alias: CD182, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, Mig-R, MigR, C-X-C chemokine receptor type 3, G protein-coupled receptor 9, IP-10 receptor, Mig receptor, chemokine (C-X-C motif) receptor 3, chemokine receptor 3, interferon-inducible protein 10 receptor
Species: human
Products:     CXCR3

Top Publications

  1. Liu C, Luo D, Reynolds B, Meher G, Katritzky A, Lu B, et al. Chemokine receptor CXCR3 promotes growth of glioma. Carcinogenesis. 2011;32:129-37 pubmed publisher
    ..In this study, we examined the role of CXCR3 in glioma progression using the GL261 murine model of malignant glioma...
  2. Choi J, Park C, Hwang M, Nam H, Chang H, Park S, et al. A common intronic variant of CXCR3 is functionally associated with gene expression levels and the polymorphic immune cell responses to stimuli. J Allergy Clin Immunol. 2008;122:1119-1126.e7 pubmed publisher
    b>CXCR3 is a chemokine receptor that plays important roles in mediating chemotactic signals and modulating the activation of lymphocytes...
  3. Krug A, Uppaluri R, Facchetti F, Dorner B, Sheehan K, Schreiber R, et al. IFN-producing cells respond to CXCR3 ligands in the presence of CXCL12 and secrete inflammatory chemokines upon activation. J Immunol. 2002;169:6079-83 pubmed
    ..Although L-selectin, CXCR4, and CCR7 are recognized as critical IPC homing mediators, the role of CXCR3 is unclear, since IPC do not respond to CXCR3 ligands in vitro...
  4. Campanella G, Lee E, Sun J, Luster A. CXCR3 and heparin binding sites of the chemokine IP-10 (CXCL10). J Biol Chem. 2003;278:17066-74 pubmed
    The chemokine IP-10 (interferon-inducible protein of 10 kDa, CXCL10) binds the G protein-coupled receptor CXCR3, which is found mainly on activated T cells and NK cells, and plays an important role in Th1-type inflammatory diseases...
  5. Wu Q, Dhir R, Wells A. Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion. Mol Cancer. 2012;11:3 pubmed publisher
    ..While often considered 'stop' signals for adherent cells, CXCR3-binding chemokines have recently been correlated positively with cancer progression though the molecular basis ..
  6. Schroepf S, Kappler R, Brand S, Prell C, Lohse P, Glas J, et al. Strong overexpression of CXCR3 axis components in childhood inflammatory bowel disease. Inflamm Bowel Dis. 2010;16:1882-90 pubmed publisher
    ..As CXCL9, CXCL10, and CXCL11 are the 3 ligands to the receptor CXCR3, the aim of this study was to investigate the colonic transcriptional activity of the CXCR3 axis and to perform ..
  7. Newton P, O Boyle G, Jenkins Y, Ali S, Kirby J. T cell extravasation: demonstration of synergy between activation of CXCR3 and the T cell receptor. Mol Immunol. 2009;47:485-92 pubmed publisher
    ..This study was designed to investigate the potential synergy between stimulation of the chemokine receptor CXCR3 and the human T cell receptor complex...
  8. Datta D, Flaxenburg J, Laxmanan S, Geehan C, Grimm M, Waaga Gasser A, et al. Ras-induced modulation of CXCL10 and its receptor splice variant CXCR3-B in MDA-MB-435 and MCF-7 cells: relevance for the development of human breast cancer. Cancer Res. 2006;66:9509-18 pubmed
    ..Human breast cancer cells express the chemokine CXCL10 (IP-10) and also its receptor CXCR3. In this study, we have investigated the role of Ras activation in the regulation of CXCL10 and its receptor ..
  9. Smit M, Verdijk P, van der Raaij Helmer E, Navis M, Hensbergen P, Leurs R, et al. CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase. Blood. 2003;102:1959-65 pubmed
    The chemokines CXCL9, 10, and 11 exert their action via CXC chemokine receptor-3 (CXCR3), a receptor highly expressed on activated T cells...

More Information

Publications85

  1. Sfriso P, Oliviero F, Calabrese F, Miorin M, Facco M, Contri A, et al. Epithelial CXCR3-B regulates chemokines bioavailability in normal, but not in Sjogren's syndrome, salivary glands. J Immunol. 2006;176:2581-9 pubmed
    Expression of CXCR3-targeting chemokines have been demonstrated in several diseases, suggesting a critical role for CXCR3 in recruiting activated T cells to sites of immune-mediated inflammation...
  2. Dagan Berger M, Feniger Barish R, Avniel S, Wald H, Galun E, Grabovsky V, et al. Role of CXCR3 carboxyl terminus and third intracellular loop in receptor-mediated migration, adhesion and internalization in response to CXCL11. Blood. 2006;107:3821-31 pubmed
    The chemokine receptor CXCR3 is predominantly expressed on activated T and natural killer (NK) cells. CXCR3 and its ligands, CXCL11, CXCL10, and CXCL9, play a major role in T-helper 1 (Th1)-dependent inflammatory responses...
  3. Bonecchi R, Bianchi G, Bordignon P, D Ambrosio D, Lang R, Borsatti A, et al. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med. 1998;187:129-34 pubmed
    ..Here we report that among four CXC (CXCR1-4) and five CC (CCR1-5) chemokine receptors analyzed, CXCR3 and CCR5 are preferentially expressed in human Th1s...
  4. Hosomi S, Oshitani N, Kamata N, Sogawa M, Okazaki H, Tanigawa T, et al. Increased numbers of immature plasma cells in peripheral blood specifically overexpress chemokine receptor CXCR3 and CXCR4 in patients with ulcerative colitis. Clin Exp Immunol. 2011;163:215-24 pubmed publisher
    ..Many peripheral blood immature plasma cells were positive for CXCR3, CXCR4, CCR9 and CCR10. Expression of CXCR3 and CXCR4 in UC patients was significantly higher than in controls...
  5. Lammers K, Lu R, Brownley J, Lu B, Gerard C, Thomas K, et al. Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology. 2008;135:194-204.e3 pubmed publisher
    ..In vitro experiments with chemokine receptor CXCR3 transfectants were performed to confirm binding of gliadin and/or 26 overlapping 20mer alpha-gliadin synthetic ..
  6. Weng Y, Siciliano S, Waldburger K, Sirotina Meisher A, Staruch M, Daugherty B, et al. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998;273:18288-91 pubmed
    ..Recently both chemokines have been shown to be functional agonists of the same G-protein-coupled receptor, CXCR3. We now report the pharmacological characterization of CXCR3 and find that, when heterologously expressed, CXCR3 ..
  7. Loetscher M, Gerber B, Loetscher P, Jones S, Piali L, Clark Lewis I, et al. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996;184:963-9 pubmed
    ..2-36.9% identity with the five known CC chemokine receptors. The IP10/Mig receptor is highly expressed in IL-2-activated T lymphocytes, but is not detectable in resting T lymphocytes...
  8. Lasagni L, Francalanci M, Annunziato F, Lazzeri E, Giannini S, Cosmi L, et al. An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. J Exp Med. 2003;197:1537-49 pubmed
    ..These multiple activities are apparently mediated by a unique G protein-coupled receptor, termed CXCR3. The chemokine CXCL4/PF4 shares several activities with CXCL9, CXCL10, and CXCL11, including a powerful ..
  9. Mueller A, Meiser A, McDonagh E, Fox J, Petit S, Xanthou G, et al. CXCL4-induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3. J Leukoc Biol. 2008;83:875-82 pubmed publisher
    ..Recently, a variant of the human chemokine receptor CXCR3 (CXCR3-B) was described, which transduced apoptotic but not chemotactic signals in microvascular endothelial cells ..
  10. Cole K, Strick C, Paradis T, Ogborne K, Loetscher M, Gladue R, et al. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J Exp Med. 1998;187:2009-21 pubmed
    ..I-TAC interacts selectively with CXCR3, which is the receptor for two other IFN-inducible chemokines, the IFN-gamma-inducible 10-kD protein (IP-10) and ..
  11. Rabquer B, Tsou P, Hou Y, Thirunavukkarasu E, Haines G, Impens A, et al. Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis. Arthritis Res Ther. 2011;13:R18 pubmed publisher
    ..by interferon-? (IFN-?) (MIG/CXCL9) and IFN-inducible protein 10 (IP-10/CXCL10), inhibit angiogenesis by binding CXCR3. In addition, CXCL16 promotes angiogenesis by binding its unique receptor CXCR6...
  12. Lo B, Yu M, Zloty D, Cowan B, Shapiro J, McElwee K. CXCR3/ligands are significantly involved in the tumorigenesis of basal cell carcinomas. Am J Pathol. 2010;176:2435-46 pubmed publisher
    ..In this study, quantitative RT-PCR revealed that the chemokines CXCL9, 10, 11, and their receptor CXCR3 were significantly upregulated by an average 22.6-fold, 9.2-fold, 26.6-fold, and 4...
  13. Romagnani P, Annunziato F, Lasagni L, Lazzeri E, Beltrame C, Francalanci M, et al. Cell cycle-dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity. J Clin Invest. 2001;107:53-63 pubmed
    ..IP-10 and Mig share a common functional receptor on activated T lymphocytes, named CXC chemokine receptor 3 (CXCR3)...
  14. Tacke F, Zimmermann H, Berres M, Trautwein C, Wasmuth H. Serum chemokine receptor CXCR3 ligands are associated with progression, organ dysfunction and complications of chronic liver diseases. Liver Int. 2011;31:840-9 pubmed publisher
    ..In viral hepatitis and primary biliary cirrhosis, a predominant chemokine receptor expressed in the liver is CXCR3, suggesting that its specific ligands are important in the progression of chronic liver diseases across different ..
  15. Laragione T, Brenner M, Sherry B, Gulko P. CXCL10 and its receptor CXCR3 regulate synovial fibroblast invasion in rheumatoid arthritis. Arthritis Rheum. 2011;63:3274-83 pubmed publisher
    ..This study was undertaken to analyze the role of CXCL10 and its receptor CXCR3 in regulation of the invasive properties of FLS...
  16. Datta D, Contreras A, Grimm M, Waaga Gasser A, Briscoe D, Pal S. Calcineurin inhibitors modulate CXCR3 splice variant expression and mediate renal cancer progression. J Am Soc Nephrol. 2008;19:2437-46 pubmed publisher
    ..Recent studies suggested that the chemokine receptor CXCR3 may play important roles in tumorigenesis...
  17. Petrai I, Rombouts K, Lasagni L, Annunziato F, Cosmi L, Romanelli R, et al. Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-B. Int J Biochem Cell Biol. 2008;40:1764-74 pubmed publisher
    Chemokines binding the CXCR3 receptor have been shown to inhibit angiogenesis via the CXCR3-B isoform, but the underlying molecular mechanisms are unknown...
  18. Ostvik A, Granlund A, Bugge M, Nilsen N, Torp S, Waldum H, et al. Enhanced expression of CXCL10 in inflammatory bowel disease: potential role of mucosal Toll-like receptor 3 stimulation. Inflamm Bowel Dis. 2013;19:265-74 pubmed publisher
    ..The chemokine CXCL10 and its receptor CXCR3 were among the upregulated genes...
  19. Stanford M, Issekutz T. The relative activity of CXCR3 and CCR5 ligands in T lymphocyte migration: concordant and disparate activities in vitro and in vivo. J Leukoc Biol. 2003;74:791-9 pubmed
    ..as rheumatoid arthritis and multiple sclerosis, T cells in the inflamed tissue express the chemokine receptors CXCR3 and CCR5, and the chemokine ligands (CCL) of these receptors are present in the inflammatory lesions...
  20. Kelsen S, Aksoy M, Yang Y, Shahabuddin S, Litvin J, Safadi F, et al. The chemokine receptor CXCR3 and its splice variant are expressed in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2004;287:L584-91 pubmed
    Activation of the chemokine receptor CXCR3 by its cognate ligands induces several differentiated cellular responses important to the growth and migration of a variety of hematopoietic and structural cells...
  21. Aksoy M, Yang Y, Ji R, Reddy P, Shahabuddin S, Litvin J, et al. CXCR3 surface expression in human airway epithelial cells: cell cycle dependence and effect on cell proliferation. Am J Physiol Lung Cell Mol Physiol. 2006;290:L909-18 pubmed
    ..demonstrated that human bronchial epithelial cells (HBEC) constitutively express the CXC chemokine receptor CXCR3, which when activated, induces directed cell migration...
  22. Curbishley S, Eksteen B, Gladue R, Lalor P, Adams D. CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow. Am J Pathol. 2005;167:887-99 pubmed
  23. Brightling C, Ammit A, Kaur D, Black J, Wardlaw A, Hughes J, et al. The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle. Am J Respir Crit Care Med. 2005;171:1103-8 pubmed
    ..We found that CXCR3 was the most abundantly expressed chemokine receptor on human lung mast cells in the airway smooth muscle in ..
  24. Gasser O, Schmid T, Zenhaeusern G, Hess C. Cyclooxygenase regulates cell surface expression of CXCR3/1-storing granules in human CD4+ T cells. J Immunol. 2006;177:8806-12 pubmed
    ..In this study, we show that most circulating human CD4+ T cells store the inflammatory chemokine receptors CXCR3 and CXCR1 within a distinct intracellular compartment...
  25. Datta D, Banerjee P, Gasser M, Waaga Gasser A, Pal S. CXCR3-B can mediate growth-inhibitory signals in human renal cancer cells by down-regulating the expression of heme oxygenase-1. J Biol Chem. 2010;285:36842-8 pubmed publisher
    The chemokine receptor CXCR3 may play a critical role in the growth and metastasis of tumor cells, including renal tumors...
  26. Meiser A, Mueller A, Wise E, McDonagh E, Petit S, Saran N, et al. The chemokine receptor CXCR3 is degraded following internalization and is replenished at the cell surface by de novo synthesis of receptor. J Immunol. 2008;180:6713-24 pubmed
    The chemokine receptor CXCR3 is expressed on the surface of both resting and activated T lymphocytes. We describe in this study the endocytosis of CXCR3 using T lymphocytes and CXCR3 transfectants...
  27. Melter M, Exeni A, Reinders M, Fang J, McMahon G, Ganz P, et al. Expression of the chemokine receptor CXCR3 and its ligand IP-10 during human cardiac allograft rejection. Circulation. 2001;104:2558-64 pubmed
    ..for infiltration by CD3(+) T cells and the expression of the chemokine receptors CCR1, CCR3, CCR5, and CXCR3. In both cross-sectional and longitudinal analyses, the expression of each of the chemokine receptors correlated ..
  28. Oo Y, Weston C, Lalor P, Curbishley S, Withers D, Reynolds G, et al. Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver. J Immunol. 2010;184:2886-98 pubmed publisher
    ..compared with blood-derived T(regs), liver-derived T(regs) express high levels of the chemokine receptors CXCR3 and CCR4...
  29. Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur J, Hollenberg M, et al. CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy. FASEB J. 2009;23:2928-41 pubmed publisher
    ..Proteolysis of CXCL12 generates a neurotoxic molecule, CXCL12(5-67), which engages and activates CXCR3, in addition to exhibiting increased expression in the brains of patients with HIV-associated dementia (HAD)...
  30. Lacotte S, Brun S, Muller S, Dumortier H. CXCR3, inflammation, and autoimmune diseases. Ann N Y Acad Sci. 2009;1173:310-7 pubmed publisher
    b>CXCR3 is a G protein-coupled, seven-transmembrane receptor that binds and is activated by the three IFN-gamma-inducible chemokines of the CXC family named CXCL9, CXCL10, and CXCL11...
  31. Bai X, Kong B, Zhang Y, Qu X, Wang H. [Expression and significance of chemokine CXC receptor 3, 4 and their ligands at the early pregnancy decidua and villi]. Zhonghua Fu Chan Ke Za Zhi. 2008;43:904-8 pubmed
    ..Gene expression of CXCR3 and CXCR4 in decidua NK cells and CXCL9, CXCL10 and CXCL12 in early pregnancy decidua and villi was assessed by RT-..
  32. Slaney C, von Scheidt B, Davenport A, Beavis P, Westwood J, Mardiana S, et al. Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting. Clin Cancer Res. 2017;23:2478-2490 pubmed publisher
    ..Durable tumor responses required the chemokine receptor CXCR3 and exogenous IL2, but were independent of IFNγ...
  33. Würsch D, Ormsby C, Romero Rodríguez D, Olvera García G, Zuniga J, Jiang W, et al. CD38 Expression in a Subset of Memory T Cells Is Independent of Cell Cycling as a Correlate of HIV Disease Progression. Dis Markers. 2016;2016:9510756 pubmed publisher
    ..infection, stratified in maturation subpopulations, and subpopulation subsets defined by the expression of CXCR5, CXCR3, and CCR4...
  34. Alves C, Ober Blöbaum J, Brouwers Haspels I, Asmawidjaja P, Mus A, Razawy W, et al. Dendritic Cell-Specific Deletion of β-Catenin Results in Fewer Regulatory T-Cells without Exacerbating Autoimmune Collagen-Induced Arthritis. PLoS ONE. 2015;10:e0142972 pubmed publisher
    ..and of regulatory T cells (Tregs) (CD4+CD25highFoxP3+), but no changes in the frequency of splenic Th17 (CCR6+CXCR3-CCR4+), Th2 (CCR6-CXCR3-CCR4+) and Th1 (CCR6-CXCR3+CCR4-) cells were observed in these mice under CIA condition...
  35. Sava F, Treszl A, Hajdu J, Toldi G, Rigo J, Tulassay T, et al. Plasma vitamin D levels at birth and immune status of preterm infants. Immunobiology. 2016;221:1289-92 pubmed publisher
    ..3 [9.9-45.4]ng/ml (median [range]). In infants with vitamin D level below the median the prevalence of CD4+ CXCR3+ (Th1) and CD8+ CXCR3+ cell subsets was higher, while the prevalence of CD4+ CCR4+ (Th2), CD8+ CCR4+ and ..
  36. Barbarroja Escudero J, Prieto Martin A, Monserrat Sanz J, Reyes Martin E, Diaz Martin D, Antolin Amerigo D, et al. Abnormal chemokine receptor profile on circulating T lymphocytes from nonallergic asthma patients. Int Arch Allergy Immunol. 2014;164:228-36 pubmed publisher
    ..The results were similar for CXCR3 and CCR5 expression...
  37. Ha Y, Liu H, Zhu S, Yi P, Liu W, Nathanson J, et al. Critical Role of the CXCL10/C-X-C Chemokine Receptor 3 Axis in Promoting Leukocyte Recruitment and Neuronal Injury during Traumatic Optic Neuropathy Induced by Optic Nerve Crush. Am J Pathol. 2017;187:352-365 pubmed publisher
    ..The levels of CXCL10 and CXCR3 were markedly elevated in TON, and up-regulation of CXCL10 was mediated by STAT1/3...
  38. Zhou J, Yu Q. Disruption of CXCR3 function impedes the development of Sjögren's syndrome-like xerostomia in non-obese diabetic mice. Lab Invest. 2018;98:620-628 pubmed publisher
    The chemokine receptor CXCR3 plays an important role in T cell recruitment in various immune responses and autoimmune diseases...
  39. Ouyang Y, Liu K, Hao M, Zheng R, Zhang C, Wu Y, et al. Radiofrequency ablation-increased CXCL10 is associated with earlier recurrence of hepatocellular carcinoma by promoting stemness. Tumour Biol. 2016;37:3697-704 pubmed publisher
    ..Immunofluorescence assay showed that the receptor of CXCL10, chemokine (C-X-C motif) receptor 3 (CXCR3), was significantly increased in type I, but not type II, patients after RFA...
  40. Pranzatelli M, Tate E, McGee N, Travelstead A, Verhulst S, Ransohoff R. Expression of CXCR3 and its ligands CXCL9, -10 and -11 in paediatric opsoclonus-myoclonus syndrome. Clin Exp Immunol. 2013;172:427-36 pubmed publisher
    ..To understand more clearly the role of inflammatory mediators, the concentration of CXCR3 ligands CXCL10, CXCL9 and CXCL11 was measured in 245 children with OMS and 81 paediatric controls using enzyme-..
  41. Lisignoli G, Piacentini A, Toneguzzi S, Grassi F, Tschon M, Cristino S, et al. Age-associated changes in functional response to CXCR3 and CXCR5 chemokine receptors in human osteoblasts. Biogerontology. 2003;4:309-17 pubmed
    ..It was found that CXCR1 and CXCR4 were only expressed by old but not young donors' cells. In contrast, CXCR3 and CXCR5 were expressed by both young and old donors...
  42. Steinmetz O, Turner J, Paust H, Lindner M, Peters A, Heiss K, et al. CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis. J Immunol. 2009;183:4693-704 pubmed publisher
    ..The chemokine receptor CXCR3 is highly expressed on Th1 cells and is supposed to be crucial for their trafficking into inflamed tissues...
  43. Nagpal M, Davis J, Lin T. Overexpression of CXCL10 in human prostate LNCaP cells activates its receptor (CXCR3) expression and inhibits cell proliferation. Biochim Biophys Acta. 2006;1762:811-8 pubmed
    ..LNCaP cells were transiently transfected with CXCL10 cDNA in pIRES2-EGFP vector. CXCL10, CXCR3, PSA and G3PDH mRNA levels were determined by semi-quantitative conventional and quantitative real-time RT-PCR and ..
  44. Erazo Borrás L, Álvarez Álvarez J, Perez Romero C, Orrego Arango J, Franco Restrepo J, Trujillo Vargas C. Skewed Invariant Natural Killer T (iNKT) Cells, Impaired iNKT:B Cell Help and Decreased SAP Expression in Blood Lymphocytes from Patients with Common Variable Immunodeficiency. Scand J Immunol. 2017;86:171-178 pubmed publisher
    ..The total of iNKT cells was reduced in the PB of CVID patients, especially CD4+, CD4-/CD8- and CCR5+/CXCR3+...
  45. Li J, Ge M, Lu S, Shi J, Li X, Wang M, et al. Pro-inflammatory effects of the Th1 chemokine CXCL10 in acquired aplastic anaemia. Cytokine. 2017;94:45-51 pubmed publisher
    CXCL10/IFN-γ-induced protein 10 (IP-10) and its corresponding receptor CXCR3 have long been considered to be involved in the pathophysiology of type 1 T (Th1) cell-orientated autoimmune diseases...
  46. Rahangdale S, Morgan R, Heijens C, Ryan T, Yamasaki H, Bentley E, et al. Chemokine receptor CXCR3 desensitization by IL-16/CD4 signaling is dependent on CCR5 and intact membrane cholesterol. J Immunol. 2006;176:2337-45 pubmed
    ..relationship between CD4 and other chemokine receptors, we determined the effects of IL-16 interaction with CD4 on CXCR3-induced migration...
  47. Eisenhardt M, Glässner A, Kramer B, Korner C, Sibbing B, Kokordelis P, et al. The CXCR3(+)CD56Bright phenotype characterizes a distinct NK cell subset with anti-fibrotic potential that shows dys-regulated activity in hepatitis C. PLoS ONE. 2012;7:e38846 pubmed publisher
    ..In hepatitis C, the chemokine receptor CXCR3 and its ligands have been shown to be associated with stage of fibrosis suggesting a role of these chemokines in ..
  48. Ponzetta A, Benigni G, Antonangeli F, Sciumè G, Sanseviero E, Zingoni A, et al. Multiple Myeloma Impairs Bone Marrow Localization of Effector Natural Killer Cells by Altering the Chemokine Microenvironment. Cancer Res. 2015;75:4766-77 pubmed publisher
    ..receptor axes in the multiple myeloma microenvironment, with rapid downmodulation of the chemokine receptor CXCR3 on NK cells, increased CXCL9 and CXCL10, and decreased CXCL12 expression in bone marrow...
  49. Arbelaez C, Glatigny S, Duhen R, Eberl G, Oukka M, Bettelli E. IL-7/IL-7 Receptor Signaling Differentially Affects Effector CD4+ T Cell Subsets Involved in Experimental Autoimmune Encephalomyelitis. J Immunol. 2015;195:1974-83 pubmed publisher
    ..In vivo IL-7/anti-IL-7 mAb complexes selectively expanded and enhanced the proliferation of CXCR3-expressing Th1 cells, but did not impact Th17 cells and EAE development in wild-type and IL-23R-deficient mice...
  50. Belperio J, Keane M, Burdick M, Lynch J, Xue Y, Li K, et al. Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome. J Immunol. 2002;169:1037-49 pubmed
    ..IP-10/CXCL10, and IFN-inducible T cell alpha chemoattractant (ITAC)/CXCL11) act through their shared receptor, CXCR3. Because they are potent leukocyte chemoattractants and are involved in other inflammation/fibroproliferative ..
  51. Van Den Ham K, Shio M, Rainone A, Fournier S, Krawczyk C, Olivier M. Iron prevents the development of experimental cerebral malaria by attenuating CXCR3-mediated T cell chemotaxis. PLoS ONE. 2015;10:e0118451 pubmed publisher
    ..CD4+ T cells demonstrated markedly decreased CXCR3 expression and had reduced IFNγ-responsiveness, as indicated by mitigated expression of IFNγR2 and T-bet...
  52. Jovicic N, Jeftic I, Jovanovic I, Radosavljevic G, Arsenijevic N, Lukic M, et al. Differential Immunometabolic Phenotype in Th1 and Th2 Dominant Mouse Strains in Response to High-Fat Feeding. PLoS ONE. 2015;10:e0134089 pubmed publisher
    ..and liver glycogen content, increased amount of visceral adipose tissue (VAT) and number of VAT associated CD3+CXCR3+ T cells, CD11c+ dendritic cells (DCs) and F4/80+ macrophages than BALB/c mice...
  53. Howard O, Dong H, Su S, Caspi R, Chen X, Plotz P, et al. Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate. Blood. 2005;105:4207-14 pubmed
    ..studies and single-receptor transfected cells revealed that subfamily of alpha chemokine receptors CXCR5 and CXCR3 mediated the chemotactic effect of IRBP, while only CXCR3 was required for the chemotactic response to S-Ag...
  54. Du C, Yao Y, Xue W, Zhu W, Peng Y, Gu J. The expression of chemokine receptors CXCR3 and CXCR4 in predicting postoperative tumour progression in stages I-II colon cancer: a retrospective study. BMJ Open. 2014;4:e005012 pubmed
    ..We assessed the prognostic value of chemokine receptor CXCR3 and CXCR4 in stage I/II colon cancer...
  55. Manousou P, Kolios G, Drygiannakis I, Pyrovolaki K, Bourikas L, Papadaki H, et al. Expression of a splice variant of CXCR3 in Crohn's disease patients; indication for a lymphocyte--epithelial cell interaction. J Gastroenterol Hepatol. 2008;23:1823-33 pubmed publisher
    ..CXC chemokines MIG, IP-10, and I-TAC act by binding to CXCR3 receptor on T-lymphocytes...
  56. Valverde Villegas J, de Medeiros R, Almeida S, Chies J. Immunogenetic profiling of 23 SNPs of cytokine and chemokine receptor genes through a minisequencing technique: Design, development and validation. Int J Immunogenet. 2017;44:135-144 pubmed publisher
    ..IL17A rs8193036, rs2275913 and panel 2-CCR3 rs309125, CCR4 rs6770096, rs2228428; CCR6 rs968334; CCR8 rs2853699; CXCR3 rs34334103, rs2280964;CXCR6 rs223435, rs2234358; CCL20 rs13034664, rs6749704; CCL22 rs4359426; CXCL10/IP-10 rs3921,..
  57. Priyathilaka T, Oh M, Bathige S, De Zoysa M, Lee J. Two distinct CXC chemokine receptors (CXCR3 and CXCR4) from the big-belly seahorse Hippocampus abdominalis: Molecular perspectives and immune defensive role upon pathogenic stress. Fish Shellfish Immunol. 2017;65:59-70 pubmed publisher
    CXC chemokine receptor 3 (CXCR3) and 4 (CXCR4) are members of the seven transmembrane G protein coupled receptor family, involved in pivotal physiological functions...
  58. Hole C, Leopold Wager C, Mendiola A, Wozniak K, Campuzano A, Lin X, et al. Antifungal Activity of Plasmacytoid Dendritic Cells against Cryptococcus neoformans In Vitro Requires Expression of Dectin-3 (CLEC4D) and Reactive Oxygen Species. Infect Immun. 2016;84:2493-504 pubmed publisher
    ..neoformans strain that induces protective immunity demonstrated that recruitment of pDCs to the lungs is CXCR3 dependent. Taken together, our results show that pDCs inhibit C...
  59. Liu W, Liu Y, Fu Q, Zhou L, Chang Y, Xu L, et al. Elevated expression of IFN-inducible CXCR3 ligands predicts poor prognosis in patients with non-metastatic clear-cell renal cell carcinoma. Oncotarget. 2016;7:13976-83 pubmed publisher
    IFN-inducible CXCR3 ligands (ICL), namely CXCL9, CXCL10 and CXCL11, exhibit pleiotropic roles in orchestrating immunity and angiogenesis. However, the prognosis value of them in renal cell carcinoma (RCC) was still obscure...
  60. Mizuochi T, Ito M, Saito K, Kasai M, Kunimura T, Morohoshi T, et al. Possible recruitment of peripheral blood CXCR3+ CD27+ CD19+ B cells to the liver of chronic hepatitis C patients. J Interferon Cytokine Res. 2010;30:243-52 pubmed publisher
    ..At the same time, the amount of IFN-gamma-inducible protein-10 (IP-10), a CXCR3 ligand, was markedly elevated in the plasma of CHC...
  61. Green L, Yi R, Petrusca D, Wang T, Elghouche A, Gupta S, et al. HIV envelope protein gp120-induced apoptosis in lung microvascular endothelial cells by concerted upregulation of EMAP II and its receptor, CXCR3. Am J Physiol Lung Cell Mol Physiol. 2014;306:L372-82 pubmed publisher
    ..Here we investigated the role of EMAP II and its receptor, CXCR3, in gp120-induced lung endothelial cell apoptosis...
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    ..Herein, we investigated the mechanism of how HAV infection induces the production of CXCR3 and CCR5 chemokines, such as CXCL10, CCL4 and CCL5...
  63. Lee J, Kim B, Jin W, Kim H, Ha H, Lee Z. Pathogenic roles of CXCL10 signaling through CXCR3 and TLR4 in macrophages and T cells: relevance for arthritis. Arthritis Res Ther. 2017;19:163 pubmed publisher
    ..CXCL10 increased the migration of inflammatory cells through C-X-C chemokine receptor 3 (CXCR3)-mediated, but not toll-like receptor 4 (TLR4)-mediated, ERK activation...
  64. Ehlert J, Addison C, Burdick M, Kunkel S, Strieter R. Identification and partial characterization of a variant of human CXCR3 generated by posttranscriptional exon skipping. J Immunol. 2004;173:6234-40 pubmed
    ..We now report on the discovery of a variant human CKR, CXCR3, resulting from alternative splicing via exon skipping...
  65. PEMU P, ANDERSON L, Gee B, Ofili E, Ghosh S. Early alterations of the immune transcriptome in cultured progenitor cells from obese African-American women. Obesity (Silver Spring). 2012;20:1481-90 pubmed publisher
    ..gene-expression patterns were consistent with an angiogenic-angiostatic imbalance and a downregulation of CXCR3 receptor-mediated signaling in the PCs from obese subjects...
  66. Akalin E, Dikman S, Murphy B, Bromberg J, Hancock W. Glomerular infiltration by CXCR3+ ICOS+ activated T cells in chronic allograft nephropathy with transplant glomerulopathy. Am J Transplant. 2003;3:1116-20 pubmed
    ..of human renal transplant biopsies showed expression of inducible costimulator (ICOS), the chemokine receptor CXCR3, and its ligands, Mig and IP-10, by intraglomerular and periglomerular leukocytes in biopsies with CAN and TGP but ..
  67. Singh L, Bakshi D, Majumdar S, Vasishta R, Arora S, Wig J. Expression of interferon-gamma- inducible protein-10 and its receptor CXCR3 in chronic pancreatitis. Pancreatology. 2007;7:479-90 pubmed
    The role of CXC chemokine, interferon-gamma-inducible protein-10 and its receptor CXCR3 in pathophysiology of chronic pancreatitis (CP) is not very clear...
  68. Zhang X, Feng J, Li W, Li J, Chen S, Han G. [The role of CXCR3 and its ligand I-TAC in the pathogenesis of immune thrombocytopenic purpura]. Zhonghua Nei Ke Za Zhi. 2012;51:634-7 pubmed
    To investigate the roles of the chemokine receptor CXCR3 and its ligand I-TAC in the pathogenesis of immune thrombocytopenic purpura (ITP)...
  69. Jones D, Benjamin R, Shahsafaei A, Dorfman D. The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia. Blood. 2000;95:627-32 pubmed
    ..The chemokine receptor CXCR3 has been previously shown to be widely expressed on activated T cells and to mediate T-cell chemotaxis on binding ..
  70. Bedognetti D, Spivey T, Zhao Y, Uccellini L, Tomei S, Dudley M, et al. CXCR3/CCR5 pathways in metastatic melanoma patients treated with adoptive therapy and interleukin-2. Br J Cancer. 2013;109:2412-23 pubmed publisher
    ..The recruitment of T cells through CXCR3/CCR5 chemokine ligands is critical for immune-mediated rejection...
  71. Pu Y, Li S, Zhang C, Bao Z, Yang Z, Sun L. High expression of CXCR3 is an independent prognostic factor in glioblastoma patients that promotes an invasive phenotype. J Neurooncol. 2015;122:43-51 pubmed publisher
    ..The chemokine receptor CXCR3 is involved in tumor metastasis and is used as a prognostic biomarker...
  72. Barnes J, Lumsden R, Worrell J, Counihan I, O Beirne S, Belperio J, et al. CXCR3 Requirement for the Interleukin-13-Mediated Up-Regulation of Interleukin-13Rα2 in Pulmonary Fibroblasts. Am J Respir Cell Mol Biol. 2015;53:217-25 pubmed publisher
    ..b>CXCR3 and its IFN-inducible ligands-CXCL9, CXCL10, and CXCL11-have been implicated in vascular remodeling and fibroblast ..
  73. Houman H, Hamzaoui A, Ben Ghorbal I, Khanfir M, Feki M, Hamzaoui K. Abnormal expression of chemokine receptors in Behçet's disease: relationship to intracellular Th1/Th2 cytokines and to clinical manifestations. J Autoimmun. 2004;23:267-73 pubmed
    ..the peripheral blood express a restricted array of inflammatory chemokine receptors, specifically, CCR5, CCR6 and CXCR3, but little CCR1-3...
  74. Ishida T, Inagaki H, Utsunomiya A, Takatsuka Y, Komatsu H, Iida S, et al. CXC chemokine receptor 3 and CC chemokine receptor 4 expression in T-cell and NK-cell lymphomas with special reference to clinicopathological significance for peripheral T-cell lymphoma, unspecified. Clin Cancer Res. 2004;10:5494-500 pubmed
    We recently reported expression of the chemokine receptors CXC chemokine receptor 3 (CXCR3) and CC chemokine receptor 4 (CCR4) in adult T-cell leukemia/lymphoma and showed a preferential expression of CCR4 and its association with an ..
  75. Green L, Petrusca D, Rajashekhar G, Gianaris T, Schweitzer K, Wang L, et al. Cigarette smoke-induced CXCR3 receptor up-regulation mediates endothelial apoptosis. Am J Respir Cell Mol Biol. 2012;47:807-14 pubmed publisher
    ..Here we addressed the role of the CXCR3 receptor in EMAP II-induced and IP-10-induced apoptosis in endothelial cells and its regulation by cigarette smoke...
  76. Kato H, Tsuchiya N, Tokunaga K. Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3. Genes Immun. 2000;1:330-7 pubmed
    ..In this study, systematic variation screening of the entire coding regions of CXCR1 (IL8RA), CXCR2 (IL8RB) and CXCR3 was carried out, using genomic DNA from a large number of Japanese healthy individuals and patients with rheumatic ..