CXCL13

Summary

Gene Symbol: CXCL13
Description: C-X-C motif chemokine ligand 13
Alias: ANGIE, ANGIE2, BCA-1, BCA1, BLC, BLR1L, SCYB13, C-X-C motif chemokine 13, B-cell chemoattractant, B-cell-attracting chemokine 1, B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1), B-lymphocyte chemoattractant, CXC chemokine BLC, b cell-attracting chemokine 1, b lymphocyte chemoattractant, chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant), small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant), small-inducible cytokine B13
Species: human
Products:     CXCL13

Top Publications

  1. Barone F, Bombardieri M, Manzo A, Blades M, Morgan P, Challacombe S, et al. Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjögren's syndrome. Arthritis Rheum. 2005;52:1773-84 pubmed
    ..b>CXCL13 and CCL21 have been identified in salivary glands, but their role in ectopic lymphoneogenesis in SS remains ..
  2. Chunsong H, Yuling H, Li W, Jie X, Gang Z, Qiuping Z, et al. CXC chemokine ligand 13 and CC chemokine ligand 19 cooperatively render resistance to apoptosis in B cell lineage acute and chronic lymphocytic leukemia CD23+CD5+ B cells. J Immunol. 2006;177:6713-22 pubmed
    b>CXCL13/CXCR5 and CCL19/CCR7 play a quite important role in normal physiological conditions, but the functions of both chemokine/receptor pairs in pathophysiological events are not well-investigated...
  3. Festa E, Hankiewicz K, Kim S, Skurnick J, Wolansky L, Cook S, et al. Serum levels of CXCL13 are elevated in active multiple sclerosis. Mult Scler. 2009;15:1271-9 pubmed publisher
    ..Recently it was reported that the B cell chemokine CXCL13 is elevated in MS serum and cerebrospinal fluid...
  4. El Haibi C, Singh R, Sharma P, Singh S, Lillard J. CXCL13 mediates prostate cancer cell proliferation through JNK signalling and invasion through ERK activation. Cell Prolif. 2011;44:311-9 pubmed publisher
    ..extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun N-terminal kinase-1 (JNK) and Akt signals involved in CXCL13-mediated prostate cancer (PCa) cell invasion and proliferation...
  5. Bürkle A, Niedermeier M, Schmitt Gräff A, Wierda W, Keating M, Burger J. Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia. Blood. 2007;110:3316-25 pubmed
    b>CXCL13 is a homeostatic chemokine for lymphocyte homing and positioning within follicles of secondary lymphoid tissues, acting through its cognate receptor, CXCR5...
  6. Hussain S, Zhu W, Chang S, Breen E, Vendrame E, Magpantay L, et al. Serum levels of the chemokine CXCL13, genetic variation in CXCL13 and its receptor CXCR5, and HIV-associated non-hodgkin B-cell lymphoma risk. Cancer Epidemiol Biomarkers Prev. 2013;22:295-307 pubmed publisher
    b>CXCL13 and CXCR5 are a chemokine and receptor pair whose interaction is critical for naïve B-cell trafficking and activation within germinal centers...
  7. Narayan K, Dail D, Li L, Cadavid D, Amrute S, Fitzgerald Bocarsly P, et al. The nervous system as ectopic germinal center: CXCL13 and IgG in lyme neuroborreliosis. Ann Neurol. 2005;57:813-23 pubmed
    ..To assess this issue, we developed real-time PCR measurements of IgG and CXCL13 production...
  8. Sellebjerg F, Bornsen L, Khademi M, Krakauer M, Olsson T, Frederiksen J, et al. Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS. Neurology. 2009;73:2003-10 pubmed publisher
    ..In CSF, concentrations of CXCL13, but not CXCL12, were higher in patients with CIS, RRMS, SPMS, and PPMS than in controls...
  9. Steinmetz O, Panzer U, Kneissler U, Harendza S, Lipp M, Helmchen U, et al. BCA-1/CXCL13 expression is associated with CXCR5-positive B-cell cluster formation in acute renal transplant rejection. Kidney Int. 2005;67:1616-21 pubmed
    ..The chemokine CXCL13 and its corresponding receptor CXCR5 play a central role in B-cell trafficking to secondary lymphatic tissue and ..

More Information

Publications100

  1. Rupprecht T, Plate A, Adam M, Wick M, Kastenbauer S, Schmidt C, et al. The chemokine CXCL13 is a key regulator of B cell recruitment to the cerebrospinal fluid in acute Lyme neuroborreliosis. J Neuroinflammation. 2009;6:42 pubmed publisher
    The chemokine CXCL13 is known to dictate homing and motility of B cells in lymphoid tissue and has been implicated in the formation of ectopic lymphoid tissue in chronic inflammation...
  2. Rupprecht T, Kirschning C, Popp B, Kastenbauer S, Fingerle V, Pfister H, et al. Borrelia garinii induces CXCL13 production in human monocytes through Toll-like receptor 2. Infect Immun. 2007;75:4351-6 pubmed
    Recent studies have suggested an important role for the B-cell-attracting chemokine CXCL13 in the B-cell-dominated cerebrospinal fluid (CSF) infiltrate in patients with neuroborreliosis (NB)...
  3. Moreth K, Brodbeck R, Babelova A, Gretz N, Spieker T, Zeng Brouwers J, et al. The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis. J Clin Invest. 2010;120:4251-72 pubmed publisher
    CXCL13 is a key B cell chemoattractant and marker of disease activity in patients with SLE; however, the mechanism of its induction has not been identified yet...
  4. Khademi M, Kockum I, Andersson M, Iacobaeus E, Brundin L, Sellebjerg F, et al. Cerebrospinal fluid CXCL13 in multiple sclerosis: a suggestive prognostic marker for the disease course. Mult Scler. 2011;17:335-43 pubmed publisher
    Levels of CXCL13, a potent B-cell chemoattractant, are elevated in the cerebrospinal fluid (CSF) during multiple sclerosis (MS) and are associated with markers of MS activity. Levels decrease upon effective treatments...
  5. Legler D, Loetscher M, Roos R, Clark Lewis I, Baggiolini M, Moser B. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J Exp Med. 1998;187:655-60 pubmed
  6. Del Grosso F, Coco S, Scaruffi P, Stigliani S, Valdora F, Benelli R, et al. Role of CXCL13-CXCR5 crosstalk between malignant neuroblastoma cells and Schwannian stromal cells in neuroblastic tumors. Mol Cancer Res. 2011;9:815-23 pubmed publisher
    ..Our previous gene-expression profiling analysis showed a different CXCL13 mRNA expression between SP and SR tumors...
  7. Rioja I, Hughes F, Sharp C, Warnock L, Montgomery D, Akil M, et al. Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor. Arthritis Rheum. 2008;58:2257-67 pubmed publisher
    ..factor (M-CSF), tumor necrosis factor receptor superfamily member 9, CCL23, transforming growth factor alpha, and CXCL13. Systemic levels of these 5 markers correlated with the C-reactive protein level, erythrocyte sedimentation rate, ..
  8. El Haibi C, Sharma P, Singh R, Johnson P, Suttles J, Singh S, et al. PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells. Mol Cancer. 2010;9:85 pubmed publisher
    ..receptor CXCR5, than compared to their normal counterparts, and interaction of CXCR5 with its specific ligand (CXCL13) promoted PCa cell invasion, migration, and differential matrix metalloproteinase (MMP) expression...
  9. Carlsen H, Baekkevold E, Morton H, Haraldsen G, Brandtzaeg P. Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis. Blood. 2004;104:3021-7 pubmed
    The homeostatic chemokine CXCL13 (also called B cell-attracting chemokine 1 [BCA-1] or B-lymphocyte chemoattractant [BLC]) is constitutively expressed in secondary lymphoid tissue and initiates lymphoid neogenesis when expressed ..
  10. Singh S, Singh R, Sharma P, Singh U, Rai S, Chung L, et al. Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion. Cancer Lett. 2009;283:29-35 pubmed publisher
    ..In this study, we present the first evidence that CXCL13, the only ligand for CXCR5, and IL-6 were significantly elevated in PCa patient serum compared to serum from ..
  11. Panse J, Friedrichs K, Marx A, Hildebrandt Y, Luetkens T, Barrels K, et al. Chemokine CXCL13 is overexpressed in the tumour tissue and in the peripheral blood of breast cancer patients. Br J Cancer. 2008;99:930-8 pubmed publisher
    ..In this study, microarray analyses revealed the overexpression of chemokine CXCL13 in breast cancer specimens...
  12. Alvarez E, Piccio L, Mikesell R, Klawiter E, Parks B, Naismith R, et al. CXCL13 is a biomarker of inflammation in multiple sclerosis, neuromyelitis optica, and other neurological conditions. Mult Scler. 2013;19:1204-8 pubmed publisher
    b>CXCL13, a B-cell chemokine, has been proposed as a biomarker in a variety of conditions, some of which can mimic multiple sclerosis and can have very high levels...
  13. Luther S, Ansel K, Cyster J. Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development. J Exp Med. 2003;197:1191-8 pubmed
    ..Previous studies have established an important role for CXCL13 (BLC) in the development of Peyer's patches (PP) and some peripheral lymph nodes (LNs), but the chemokine ..
  14. Pandruvada S, Yuvaraj S, Liu X, Sundaram K, Shanmugarajan S, Ries W, et al. Role of CXC chemokine ligand 13 in oral squamous cell carcinoma associated osteolysis in athymic mice. Int J Cancer. 2010;126:2319-29 pubmed publisher
    ..In this study, we identified high level expression of chemokine ligand, CXCL13 and RANK ligand (RANKL) in OSCC cells (SCC1, SCC12 and SCC14a)...
  15. Senel M, Rupprecht T, Tumani H, Pfister H, Ludolph A, Brettschneider J. The chemokine CXCL13 in acute neuroborreliosis. J Neurol Neurosurg Psychiatry. 2010;81:929-33 pubmed publisher
    Recent studies have suggested an important role of the B cell chemoattractant CXCL13 in acute neuroborreliosis (NB)...
  16. Gunn M, Ngo V, Ansel K, Ekland E, Cyster J, Williams L. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature. 1998;391:799-803 pubmed
    ..Here we describe a novel chemokine, B-lymphocyte chemoattractant (BLC), that is strongly expressed in the follicles of Peyer's patches, the spleen and lymph nodes...
  17. Yuvaraj S, Griffin A, Sundaram K, Kirkwood K, Norris J, Reddy S. A novel function of CXCL13 to stimulate RANK ligand expression in oral squamous cell carcinoma cells. Mol Cancer Res. 2009;7:1399-407 pubmed publisher
    ..The chemokine ligand, CXCL13, has been identified as a prognostic marker for OSCC development and progression...
  18. Meeuwisse C, van der Linden M, Rullmann T, Allaart C, Nelissen R, Huizinga T, et al. Identification of CXCL13 as a marker for rheumatoid arthritis outcome using an in silico model of the rheumatic joint. Arthritis Rheum. 2011;63:1265-73 pubmed publisher
    ..acid phosphatase 5b (TRAP-5b), N-telopeptide of type I collagen (NTX), angiopoietin 2 (Ang-2), and CXCL13. Serum from 74 RA patients was used to study whether radiologic joint destruction (total erosion score and total ..
  19. Tosti C, Pinzauti S, Santulli P, Chapron C, Petraglia F. Pathogenetic Mechanisms of Deep Infiltrating Endometriosis. Reprod Sci. 2015;22:1053-9 pubmed publisher
    ..decreased apoptosis (nuclear factor kappa-light-chain-enhancer of activated B cells [NF-kB], B-cell lymphoma 2 [Blc-2], and anti-Mullerian hormone) and by the increased proliferation activity related to oxidative stress (NF-kB, ..
  20. Oikawa A, Shoji J, Inada N, Sawa M. Transconjunctival immunotherapy using cholera toxin B to treat experimental allergic conjunctivitis in a mouse model. Jpn J Ophthalmol. 2011;55:534-540 pubmed publisher
    ..Transconjunctival immunotherapy using CTB can be evaluated by histological examination of eosinophils and CD4-positive T cells, and a mucosal immunity-associated chemokine and a helper T-cell-17-associated chemokine as biomarkers. ..
  21. Martinez A, Burmeister A, Ramesh G, Doyle Meyers L, Marriott I, Philipp M. Aprepitant limits in vivo neuroinflammatory responses in a rhesus model of Lyme neuroborreliosis. J Neuroinflammation. 2017;14:37 pubmed publisher
    ..We demonstrate that aprepitant treatment attenuates B. burgdorferi-induced elevations in CCL2, CXCL13, IL-17A, and IL-6 gene expression in dorsal root ganglia, spinal cord, and/or cerebrospinal fluid of rhesus ..
  22. Ramesh G, Didier P, England J, Santana Gould L, Doyle Meyers L, Martin D, et al. Inflammation in the pathogenesis of lyme neuroborreliosis. Am J Pathol. 2015;185:1344-60 pubmed publisher
    ..ELISA of cerebrospinal fluid showed significantly elevated levels of IL-6, IL-8, chemokine ligand 2, and CXCL13 and pleocytosis in all infected animals, except dexamethasone-treated animals...
  23. Stefanski H, Jonart L, Goren E, MULE J, Blazar B. A novel approach to improve immune effector responses post transplant by restoration of CCL21 expression. PLoS ONE. 2018;13:e0193461 pubmed publisher
    ..An increase in both lymphoid tissue inducer cells and the B cell chemokine CXCL13 known to be important in LN formation was observed...
  24. Novakova L, Axelsson M, Khademi M, Zetterberg H, Blennow K, Malmeström C, et al. Cerebrospinal fluid biomarkers of inflammation and degeneration as measures of fingolimod efficacy in multiple sclerosis. Mult Scler. 2017;23:62-71 pubmed publisher
    ..Concentrations of C-X-C motif chemokine 13 (CXCL13), chemokine (C-C motif) ligand 2 (CCL2), chitinase-3-like protein 1 (CHI3L1), glial fibrillary acidic protein (..
  25. Robinet M, Villeret B, Maillard S, Cron M, Berrih Aknin S, Le Panse R. Use of Toll-Like Receptor Agonists to Induce Ectopic Lymphoid Structures in Myasthenia Gravis Mouse Models. Front Immunol. 2017;8:1029 pubmed publisher
    ..Upon Poly(I:C) injections, we observed increased thymic expressions of ?-AChR, interferon-? and chemokines such as CXCL13 and CCL21 leading to B-cell recruitment. However, these changes were only transient...
  26. Sinclair A, Park L, Shah M, Drotar M, Calaminus S, Hopcroft L, et al. CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Blood. 2016;128:371-83 pubmed publisher
    ..progenitor cells [HPCs], revealing that several chemokine ligands (CXCL1-4, CXCL6, CXCL10, CXCL11, and CXCL13) were upregulated in human quiescent CD34(+)Hoescht(-)Pyronin Y(-) and primitive CD34(+)38(-), as compared with ..
  27. Bekele Y, Yibeltal D, Bobosha K, Andargie T, Lemma M, Gebre M, et al. T follicular helper cells and antibody response to Hepatitis B virus vaccine in HIV-1 infected children receiving ART. Sci Rep. 2017;7:8956 pubmed publisher
    ..Higher plasma levels (P < 0.0001) of CXCL13 were found in infected children which correlated with cTfh cell frequency at baseline...
  28. Dominguez F, Meseguer M, Aparicio Ruiz B, Piqueras P, Quiñonero A, Simón C. New strategy for diagnosing embryo implantation potential by combining proteomics and time-lapse technologies. Fertil Steril. 2015;104:908-914 pubmed publisher
    ..We analyzed seven proteins in the embryo spent media-SCF, TNFR1, PIGF-1, IFN-α2, IL-6, CXCL13, and GM-CSF-with the use of a bead-based multiplexing technology and combined this data with the exact timing (in ..
  29. Mourad N, Mounier N, Briere J, Raffoux E, Delmer A, Feller A, et al. Clinical, biologic, and pathologic features in 157 patients with angioimmunoblastic T-cell lymphoma treated within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials. Blood. 2008;111:4463-70 pubmed publisher
    ..Sixty-two cases were scored for CD10 and CXCL13 expression according to the abundance of positive lymphoid cells...
  30. Pandya J, Lundell A, Andersson K, Nordström I, Theander E, Rudin A. Blood chemokine profile in untreated early rheumatoid arthritis: CXCL10 as a disease activity marker. Arthritis Res Ther. 2017;19:20 pubmed publisher
    ..The best discriminators were CXCL9, CXCL10, CXCL13, CCL4, and CCL22, which were significantly higher in ueRA compared to HC in univariate analyses...
  31. Choi H, Kim B, Morgan A, Kim J, Kim W. Improvement of the pharmacological activity of menthol via enzymatic ?-anomer-selective glycosylation. AMB Express. 2017;7:167 pubmed publisher
    ..The in vitro glycosylation of (-)-menthol by uridine diphosphate glycosyltransferase (BLC) from Bacillus licheniformis generated (-)-menthol ?-glucoside and new (-)-menthol ?-galactoside and (-)-menthol N-..
  32. Poddar D, Basu A, Baldwin W, Kondratov R, Barik S, Mazumder B. An extraribosomal function of ribosomal protein L13a in macrophages resolves inflammation. J Immunol. 2013;190:3600-12 pubmed publisher
    ..Macrophages from these knockout animals show unregulated expression of several chemokines (e.g., CXCL13, CCL22, CCL8, and CCR3)...
  33. Carini C, Hunter E, Ramadass A, Green J, Akoulitchev A, McInnes I, et al. Chromosome conformation signatures define predictive markers of inadequate response to methotrexate in early rheumatoid arthritis. J Transl Med. 2018;16:18 pubmed publisher
    ..The CCS consisted of binary chromosome conformations in the genomic regions of IFNAR1, IL-21R, IL-23, CXCL13 and IL-17A. When tested on a cohort of 59 RA patients, the CCS provided a negative predictive value of 90...
  34. Yan Y, Wang J, Qu B, Zhang Y, Wei Y, Liu H, et al. CXCL13 and TH1/Th2 cytokines in the serum and cerebrospinal fluid of neurosyphilis patients. Medicine (Baltimore). 2017;96:e8850 pubmed publisher
    ..fluid (CSF) of HIV-negative patients with neurosyphilis before and after treatment, aiming to elucidate roles of CXCL13 and Th1/Th2 cytokines in immune response to and pathogenesis of neurosyphilis...
  35. Hähnlein J, Nadafi R, de Jong T, Ramwadhdoebe T, Semmelink J, Maijer K, et al. Impaired lymph node stromal cell function during the earliest phases of rheumatoid arthritis. Arthritis Res Ther. 2018;20:35 pubmed publisher
    ..Key LN chemokines C-C motif chemokine ligand (CCL19), CCL21 and CXCL13 were induced in LNSCs upon stimulation with tumour necrosis factor-α and lymphotoxin α1β2,..
  36. Wagner J, Weis S, Kubasta C, Panholzer J, von Oertzen T. CXCL13 as a diagnostic marker of neuroborreliosis and other neuroinflammatory disorders in an unselected group of patients. J Neurol. 2018;265:74-81 pubmed publisher
    The C-X-C motif chemokine ligand 13 (CXCL13) and its receptor CXCR5 play an important role in the homing of B-lymphocytes...
  37. Picha D, Moravcova L, Smíšková D. Prospective study on the chemokine CXCL13 in neuroborreliosis and other aseptic neuroinfections. J Neurol Sci. 2016;368:214-20 pubmed publisher
    The study evaluates the clinical significance of CXCL13 (leukocyte chemoattractant synthesized in CSF ) in Lyme neuroborreliosis (LNB) and other aseptic CNS infections...
  38. Guo J, Qian J, Zhang R. The pathological features of ectopic lymphoid neogenesis in idiopathic dacryoadenitis. BMC Ophthalmol. 2016;16:66 pubmed publisher
    ..T and B cell compartmentalization, follicular dendritic cells and the expression of CXCL13 and CCL21 were analyzed...
  39. Johnson P, Molosh A, Fitz S, Arendt D, Deehan G, Federici L, et al. Pharmacological depletion of serotonin in the basolateral amygdala complex reduces anxiety and disrupts fear conditioning. Pharmacol Biochem Behav. 2015;138:174-9 pubmed publisher
    The basolateral and lateral amygdala nuclei complex (BLC) is implicated in a number of emotional responses including conditioned fear and social anxiety...
  40. Han J, Suh C, Jung J, Nam J, Kwon J, Yim H, et al. Association of CXCL10 and CXCL13 levels with disease activity and cutaneous manifestation in active adult-onset Still's disease. Arthritis Res Ther. 2015;17:260 pubmed publisher
    ..b>CXCL13 is constitutively expressed in secondary lymphoid tissues, and the expression is upregulated by TNF-α, via T ..
  41. Barstad B, Tveitnes D, Noraas S, Selvik Ask I, Saeed M, Bosse F, et al. Cerebrospinal Fluid B-lymphocyte Chemoattractant CXCL13 in the Diagnosis of Acute Lyme Neuroborreliosis in Children. Pediatr Infect Dis J. 2017;36:e286-e292 pubmed publisher
    ..The B-lymphocyte chemoattractant CXCL13 in the cerebrospinal fluid (CSF) may be useful in diagnosing LNB, but its specificity has not been evaluated in ..
  42. Chapman K, Ge R, Monni E, Tatarishvili J, Ahlenius H, Arvidsson A, et al. Inflammation without neuronal death triggers striatal neurogenesis comparable to stroke. Neurobiol Dis. 2015;83:1-15 pubmed publisher
    ..Among the upregulated factors, one chemokine, CXCL13, was found to promote neuroblast migration from neonatal mouse SVZ explants in vitro...
  43. Baxter V, Griffin D. Interferon gamma modulation of disease manifestation and the local antibody response to alphavirus encephalomyelitis. J Gen Virol. 2016;97:2908-2925 pubmed publisher
    ..antibody was associated with lower expression of mRNAs for B-cell attracting chemokines CXCL9, CXCL10 and CXCL13 and fewer B cells in the CNS...
  44. Takagi R, Higashi T, Hashimoto K, Nakano K, Mizuno Y, Okazaki Y, et al. B cell chemoattractant CXCL13 is preferentially expressed by human Th17 cell clones. J Immunol. 2008;181:186-9 pubmed
    ..human allo-reactive Th17 cell clones and demonstrate that human Th17, but not Th1 or Th2, cells express B cell chemoattractant CXCL13, by using DNA chips, RT-PCR, and ELISA...
  45. Bohlooli S, Bohlooli S, Aslanian R, Nouri F, Teimourzadeh A. Aqueous extract of Agrostemma githago seed inhibits caspase-3 and induces cell-cycle arrest at G1 phase in AGS cell line. J Ethnopharmacol. 2015;175:295-300 pubmed publisher
    ..demonstrated that the extract exerts its cytotoxic effect mainly via apoptosis, in accordance with the annexin V, blc-2, and caspase-3 results...
  46. Gauvin J, Chagnon Choquet J, Poudrier J, Roger M. Fluctuations in Blood Marginal Zone B-Cell Frequencies May Reflect Migratory Patterns Associated with HIV-1 Disease Progression Status. PLoS ONE. 2016;11:e0155868 pubmed publisher
    ..We found important modulations of CXCL13-CXCR5, CXCL12-CXCR4/CXCR7, CCL20-CCR6 and CCL25-CCR9 chemokine-axes and increased cell migration patterns in HIV ..
  47. Li G, Song H, Chen L, Yang W, Nan K, Lu P. TUG1 promotes lens epithelial cell apoptosis by regulating miR-421/caspase-3 axis in age-related cataract. Exp Cell Res. 2017;356:20-27 pubmed publisher
    ..The apoptotic-related protein, caspase-3, Bax and blc-2 were analyzed by western blot...
  48. Fang L, Sun J, Li L, Deng H, Huang T, Yang Q, et al. Dissemination of the chromosomally encoded CMY-2 cephalosporinase gene in Escherichia coli isolated from animals. Int J Antimicrob Agents. 2015;46:209-13 pubmed publisher
    ..A CMY gene-containing region composed of five open reading frames (ORFs) (ISEcp1-blaCMY-2-blc-sugE-ΔencR) was observed in plasmids from eight strains...
  49. Ferretti E, Ponzoni M, Doglioni C, Pistoia V. IL-17 superfamily cytokines modulate normal germinal center B cell migration. J Leukoc Biol. 2016;100:913-918 pubmed
    ..by stromal cell-derived CXCL12, whereas CCs express CXCR5 and are recruited to the light zone along a gradient of CXCL13 produced by follicular dendritic cells (FDCs)...
  50. Jiang B, Cao D, Zhang X, Zhang Z, He L, Li C, et al. CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5. J Clin Invest. 2016;126:745-61 pubmed publisher
    ..C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5...
  51. Remy M, Schöbi N, Kottanattu L, Pfister S, Duppenthaler A, Suter Riniker F. Cerebrospinal fluid CXCL13 as a diagnostic marker of neuroborreliosis in children: a retrospective case-control study. J Neuroinflammation. 2017;14:173 pubmed publisher
    ..The elevation of the chemokine CXCL13 in the cerebrospinal fluid (CSF) of adult patients with LNB has been demonstrated and suggested as a new ..
  52. Iwanowski P, Losy J, Kramer L, Wójcicka M, Kaufman E. CXCL10 and CXCL13 chemokines in patients with relapsing remitting and primary progressive multiple sclerosis. J Neurol Sci. 2017;380:22-26 pubmed publisher
    ..CXCL10 and CXCL13 chemokines act as chemoattractants and modulators of proinflammatory reactions promoting process of demyelination...
  53. Mehta B, Auger D, González J, Workman V, Chen X, Chow K, et al. Detection of elevated right ventricular extracellular volume in pulmonary hypertension using Accelerated and Navigator-Gated Look-Locker Imaging for Cardiac T1 Estimation (ANGIE) cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2015;17:110 pubmed publisher
    ..have limited resolution, but accelerated and navigator-gated Look-Locker imaging for cardiac T1 estimation (ANGIE) is a novel CMR sequence with spatial resolution suitable for T1 mapping of the RV...
  54. Pacholewska A, Jagannathan V, Drögemüller M, Klukowska Rötzler J, Lanz S, Hamza E, et al. Impaired Cell Cycle Regulation in a Natural Equine Model of Asthma. PLoS ONE. 2015;10:e0136103 pubmed publisher
    ..An important novel finding was a strong upregulation of CXCL13 together with many genes involved in cell cycle regulation in stimulated samples from RAO affected horses, in ..
  55. Li Y, Gudjonsson J, Woods T, Zhang T, Johnston A, Stoll S, et al. Transgenic expression of S100A2 in hairless mouse skin enhances Cxcl13 mRNA in response to solar-simulated radiation. Arch Dermatol Res. 2009;301:205-17 pubmed publisher
    ..However, the only S100A2-dependent difference we observed was an induction of Cxcl13 transcripts in TG, but not WT mice (4.4-fold vs. 0.7-fold, n = 3, P = 0.022)...
  56. Akram M, Bhat I, Anwar S, Ahmad A, Kabir Ud Din -. Biophysical perspective of the binding of ester-functionalized gemini surfactants with catalase. Int J Biol Macromol. 2016;88:614-23 pubmed publisher
    ..examined the binding interactions of three ester-functionalized surfactants (m-E2-m) with bovine liver catalase (BLC, 10?M) by employing a multi-technique approach...
  57. Doloff J, Veiseh O, Vegas A, Tam H, Farah S, Ma M, et al. Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates. Nat Mater. 2017;16:671-680 pubmed publisher
    ..Macrophages, via CXCL13, lead to downstream B cell recruitment, which further potentiated fibrosis, as confirmed by B cell knockout and ..
  58. Jiang J, Karimi O, Ouburg S, Champion C, Khurana A, Liu G, et al. Interruption of CXCL13-CXCR5 axis increases upper genital tract pathology and activation of NKT cells following chlamydial genital infection. PLoS ONE. 2012;7:e47487 pubmed publisher
    ..We reported that CXCL13 was induced in fallopian tube tissue following C. trachomatis infection...
  59. Ezzat M, El Gammasy T, Shaheen K, Shokr E. Elevated production of serum B-cell-attracting chemokine-1 (BCA-1/CXCL13) is correlated with childhood-onset lupus disease activity, severity, and renal involvement. Lupus. 2011;20:845-54 pubmed publisher
    ..lupus erythematosus (SLE) is a prototype of systemic autoimmune disease in which cytokines such as B lymphocyte chemoattractant (BLC) or CXC motif ligand 13 (CXCL13) play an important role as major regulators of B1 and B2 cell ..
  60. Kramer J, Klimatcheva E, Rothstein T. CXCL13 is elevated in Sjögren's syndrome in mice and humans and is implicated in disease pathogenesis. J Leukoc Biol. 2013;94:1079-89 pubmed publisher
    ..B-cell abnormalities have been identified in SS. CXCL13 directs B-cell chemotaxis and is elevated in several autoimmune diseases...
  61. Zhu S, Lin J, Qiao G, Wang X, Xu Y. Tim-3 identifies exhausted follicular helper T cells in breast cancer patients. Immunobiology. 2016;221:986-93 pubmed publisher
    ..New evidence suggested that the infiltration of CXCL13-expressing CD4(+) follicular helper cells (Tfh) in breast tumor predicted better survival...
  62. Chen L, Huang Z, Yao G, Lyu X, Li J, Hu X, et al. The expression of CXCL13 and its relation to unfavorable clinical characteristics in young breast cancer. J Transl Med. 2015;13:168 pubmed publisher
    ..Impressively, the CXCL13 (C-X-C motif chemokine 13) expression level showed the most significant difference (FC = 2.64, P = 8...
  63. Shiao Y, Lee C, Hsu Y, Huang S, Lin C, Li L, et al. Ectopic and high CXCL13 chemokine expression in myasthenia gravis with thymic lymphoid hyperplasia. J Neuroimmunol. 2010;221:101-6 pubmed publisher
    Myasthenia gravis (MG) is an antibody and complement mediated autoimmune disease. Serum CXC chemokine ligand 13 (CXCL13) was found to be elevated in MG patients and high CXCL13 level was associated with severe clinical stages, especially ..
  64. Singh R, Gupta P, Kloecker G, Singh S, Lillard J. Expression and clinical significance of CXCR5/CXCL13 in human non‑small cell lung carcinoma. Int J Oncol. 2014;45:2232-40 pubmed publisher
    CXCR5 and/or CXCL13 expression is elevated in certain carcinomas and lymphomas...
  65. Husson H, Freedman A, Cardoso A, Schultze J, Munoz O, Strola G, et al. CXCL13 (BCA-1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cells. Br J Haematol. 2002;119:492-5 pubmed
    ..The chemokine/chemokine receptor pair CXCL13/CXCR5 is required for the architectural organization of B cells within lymphoid follicles...
  66. Barone F, Bombardieri M, Rosado M, Morgan P, Challacombe S, De Vita S, et al. CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: association with reactive and malignant areas of lymphoid organization. J Immunol. 2008;180:5130-40 pubmed
    The chemokines (CKs) CXCL13, CCL21, and CXCL12 are known to play differential roles in the organization of the lymphoid tissues and the development of lymphoid malignancies...
  67. Smith J, Braziel R, Paoletti S, Lipp M, Uguccioni M, Rosenbaum J. Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma. Blood. 2003;101:815-21 pubmed
    ..specimens from 24 patients with PCNSL to investigate the expression of B cell-attracting chemokine 1 (BCA-1, CXCL13), a lymphoid chemokine involved in B-cell compartmental homing within secondary lymphoid organs and recently ..
  68. Cagigi A, Mowafi F, Phuong Dang L, Tenner Racz K, Atlas A, Grutzmeier S, et al. Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection. Blood. 2008;112:4401-10 pubmed publisher
    ..Interestingly, an increased expression of CXC chemokine ligand 13 (CXCL13), the ligand for CXCR5, was found in peripheral B cells from HIV-1-infected patients...
  69. Ohmatsu H, Sugaya M, Kadono T, Tamaki K. CXCL13 and CCL21 are expressed in ectopic lymphoid follicles in cutaneous lymphoproliferative disorders. J Invest Dermatol. 2007;127:2466-8 pubmed
  70. Paoletti S, Petkovic V, Sebastiani S, Danelon M, Uguccioni M, Gerber B. A rich chemokine environment strongly enhances leukocyte migration and activities. Blood. 2005;105:3405-12 pubmed
    ..Chemokine-induced synergism might provide an amplification system in "chemokine-rich" tissues, rendering leukocytes more competent to respond to migratory cues. ..
  71. Duan Z, Chen X, Liang Z, Zeng Y, Zhu F, Long L, et al. Genetic polymorphisms of CXCR5 and CXCL13 are associated with non-responsiveness to the hepatitis B vaccine. Vaccine. 2014;32:5316-22 pubmed publisher
    ..A total of 24 single nucleotide polymorphisms (SNPs) in 6 TfH related genes (CXCR5, ICOS, CXCL13, IL-21, BCL6 and CD40L) were investigated in 20 non-responders and 45 responders to HBV vaccination...
  72. Young T, Wedd A, Xiao Z. Evaluation of Cu(i) binding to the E2 domain of the amyloid precursor protein - a lesson in quantification of metal binding to proteins via ligand competition. Metallomics. 2018;10:108-119 pubmed publisher
    ..This study also provides new insights into a potential correlation of APP functions regulated by copper binding and heparin interaction. ..
  73. Rashtbari S, Dehghan G, Yekta R, Jouyban A. Investigation of the binding mechanism and inhibition of bovine liver catalase by quercetin: Multi-spectroscopic and computational study. Bioimpacts. 2017;7:147-153 pubmed publisher
    ..The interaction of bovine liver catalase (BLC) with QUE has been studied in this research by using different spectroscopic methods...
  74. Lisignoli G, Toneguzzi S, Piacentini A, Cristino S, Grassi F, Cavallo C, et al. CXCL12 (SDF-1) and CXCL13 (BCA-1) chemokines significantly induce proliferation and collagen type I expression in osteoblasts from osteoarthritis patients. J Cell Physiol. 2006;206:78-85 pubmed
    To evaluate the role of CXC chemokines CXCL8 (IL8), CXCL10 (IP-10), CXCL12 (SDF-1), and CXCL13 (BCA-1) in bone remodeling, we analyzed their effects on osteoblasts (OBs) obtained from subchondral trabecular bone tissue of osteoarthritis (..
  75. Lee S, Kang S, Kang E, Choi B, Masek Hammerman K, Syed J, et al. CXCL10/CXCR3 axis is associated with disease activity and the development of mucocutaneous lesions in patients with Behçet's disease. Sci Rep. 2017;7:14720 pubmed publisher
    ..Serum CXC chemokines (CXCL1, CXCL8, CXCL9, CXCL10, CXCL12, CXCL13 and CXCL16) and cell surface marker expression (CD3, CD4 and CXCR3) in peripheral blood mononuclear cells (PBMCs) ..
  76. Zhang Y, Yu K, Hu S, Lou Y, Liu C, Xu J, et al. MDC and BLC are independently associated with the significant risk of early stage lung adenocarcinoma. Oncotarget. 2016;7:83051-83059 pubmed publisher
    ..29 (0.16-0.53) for MDC and 4.17 (2.23-7.79) for BLC for the comparison of patients in the 4th quartile with the 1st quartile (both P<0.0001)...
  77. Kowarik M, Cepok S, Sellner J, Grummel V, Weber M, Korn T, et al. CXCL13 is the major determinant for B cell recruitment to the CSF during neuroinflammation. J Neuroinflammation. 2012;9:93 pubmed publisher
    The chemokines and cytokines CXCL13, CXCL12, CCL19, CCL21, BAFF and APRIL are believed to play a role in the recruitment of B cells to the central nervous system (CNS) compartment during neuroinflammation...
  78. Yeh R, Hsieh C, Chen K. Screening lactic acid bacteria to manufacture two-stage fermented feed and pelleting to investigate the feeding effect on broilers. Poult Sci. 2018;97:236-246 pubmed publisher
    ..numbers of each sex, randomly assigned into control, BS + Bacillus coagulans L12 (BBC), BS + Lactobacillus casei (BLC), BS + Lactobacillus acidophilus (BLA), BS + Lactobacillus acidophilus L15 (BLA15), BS + Lactobacillus delbruekckii ..
  79. Sun W, Qiu Z, Huang W, Cao M. Gene expression profiles and protein?protein interaction networks during tongue carcinogenesis in the tumor microenvironment. Mol Med Rep. 2017;: pubmed publisher
    ..The PPI network revealed that C?X?C motif chemokine ligand (Cxcl)1, Cxcl10, Cxcl13, Cxcl2 and pro?platelet basic protein were a key cluster for epithelia, and interleukin (Il)1?, Il1 receptor 2, ..
  80. Li Y, Wang W, Tang L, He X, Yan X, Zhang X, et al. Chemokine (C-X-C motif) ligand 13 promotes intrahepatic chemokine (C-X-C motif) receptor 5+ lymphocyte homing and aberrant B-cell immune responses in primary biliary cirrhosis. Hepatology. 2015;61:1998-2007 pubmed publisher
    ..Indeed, elevated expression of intrahepatic chemokine (C-X-C motif) ligand 13 (CXCL13), a key chemokine of CXCR5(+) cells, was uniquely found within the portal tracts in PBC, accompanied by ..
  81. Ferraro D, Galli V, Vitetta F, Simone A, Bedin R, Del Giovane C, et al. Cerebrospinal fluid CXCL13 in clinically isolated syndrome patients: Association with oligoclonal IgM bands and prediction of Multiple Sclerosis diagnosis. J Neuroimmunol. 2015;283:64-9 pubmed publisher
    Cerebrospinal fluid (CSF) CXCL13 was shown to correlate with markers of intrathecal inflammation and CSF oligoclonal IgM bands (IgMOB) have been associated with a more severe Multiple Sclerosis (MS) course...
  82. Havenar Daughton C, Lindqvist M, Heit A, Wu J, Reiss S, Kendric K, et al. CXCL13 is a plasma biomarker of germinal center activity. Proc Natl Acad Sci U S A. 2016;113:2702-7 pubmed publisher
    Significantly higher levels of plasma CXCL13 [chemokine (C-X-C motif) ligand 13] were associated with the generation of broadly neutralizing antibodies (bnAbs) against HIV in a large longitudinal cohort of HIV-infected individuals...
  83. Olivier B, Cailotto C, van der Vliet J, Knippenberg M, Greuter M, Hilbers F, et al. Vagal innervation is required for the formation of tertiary lymphoid tissue in colitis. Eur J Immunol. 2016;46:2467-2480 pubmed publisher
    ..colon develops following the expression of lymphoid tissue-inducing chemokines and adhesion molecules, such as CXCL13 and VCAM-1, respectively, which are produced by stromal organizer cells...
  84. Percopo C, Brenner T, Ma M, Kraemer L, Hakeem R, Lee J, et al. SiglecF+Gr1hi eosinophils are a distinct subpopulation within the lungs of allergen-challenged mice. J Leukoc Biol. 2017;101:321-328 pubmed publisher
    ..The lymphocyte-targeting cytokines CXCL13 and IL-27 were identified only in the SiglecF+Gr1hi eosinophil population (at 3.9 and 4...
  85. Ye Y, Zhang X, Zhang M, Ling N, Zeng H, Gao J, et al. Potential factors involved in virulence of Cronobacter sakazakii isolates by comparative transcriptome analysis. J Dairy Sci. 2017;100:8826-8837 pubmed publisher
    ..Furthermore, the expression abundance of outer membrane protein or lipoprotein genes (ompW, slyB, blc, tolC, and lolA), potential virulence-related factors (hlyIII and hha), and regulation factors (sdiA, cheY, Bss, ..
  86. Carroll J, Race B, Phillips K, Striebel J, Chesebro B. Statins are ineffective at reducing neuroinflammation or prolonging survival in scrapie-infected mice. J Gen Virol. 2017;98:2190-2199 pubmed publisher
    ..simvastatin therapy did not reduce any of the tested genes, but did slightly increase the expression of Ccl2 and Cxcl13. Our studies indicate that none of the three statins tested were effective in reducing scrapie-induced ..
  87. Li R, Ma L, Huang H, Ou S, Yuan J, Xu T, et al. Altered Expression of CXCL13 and CXCR5 in Intractable Temporal Lobe Epilepsy Patients and Pilocarpine-Induced Epileptic Rats. Neurochem Res. 2017;42:526-540 pubmed publisher
    ..C-X-C motif chemokine ligand 13 (CXCL13) and its only receptor, C-X-C motif chemokine receptor 5 (CXCR5), are highly expressed in the central nervous ..
  88. Jenh C, Cox M, Hipkin W, Lu T, Pugliese Sivo C, Gonsiorek W, et al. Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor. Cytokine. 2001;15:113-21 pubmed
    The CXC chemokine CXCL13, known as BCA-1 (B cell-attracting chemokine 1) or BLC (B-lymphocyte chemoattractant), has been identified as an efficacious attractant selective for B lymphocytes...
  89. Cao Y, Qin X, Wang N, Jiang E, Han M, Ma Y, et al. B Lymphocyte Chemoattractant (CXCL13) Is an Indicator of Acute Gastrointestinal GVHD in Murine Model. Inflammation. 2017;40:1678-1687 pubmed publisher
    ..The data demonstrated that the expression of B lymphocyte chemoattractant (CXCL13) was increased by ~10-, 12-, and 16-fold upon the occurrence of aGVHD compared with infection, ..
  90. Karrasch M, Fingerle V, Boden K, Darr A, Baier M, Straube E, et al. Neuroborreliosis and acute encephalopathy: The use of CXCL13 as a biomarker in CNS manifestations of Lyme borreliosis. Ticks Tick Borne Dis. 2018;9:415-417 pubmed publisher
    ..This was mirrored in the measurement of CXCL13, which is suggested as a complementary biomarker...
  91. Fava R, Kennedy S, Wood S, Bolstad A, Bienkowska J, Papandile A, et al. Lymphotoxin-beta receptor blockade reduces CXCL13 in lacrimal glands and improves corneal integrity in the NOD model of Sjögren's syndrome. Arthritis Res Ther. 2011;13:R182 pubmed publisher
    ..HEV), by Affymetrix gene-array analysis and real-time PCR for differential gene expression, and by ELISA for CXCL13 protein. Leukocytes from lacrimal glands were analyzed by flow-cytometry...