Gene Symbol: CXCL11
Description: C-X-C motif chemokine ligand 11
Alias: H174, I-TAC, IP-9, IP9, SCYB11, SCYB9B, b-R1, C-X-C motif chemokine 11, beta-R1, chemokine (C-X-C motif) ligand 11, interferon gamma-inducible protein 9, interferon-inducible T-cell alpha chemoattractant, small inducible cytokine B11, small inducible cytokine subfamily B (Cys-X-Cys), member 11, small inducible cytokine subfamily B (Cys-X-Cys), member 9B
Species: human
Products:     CXCL11

Top Publications

  1. Rani M, Foster G, Leung S, Leaman D, Stark G, Ransohoff R. Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha. J Biol Chem. 1996;271:22878-84 pubmed
  2. Cole K, Strick C, Paradis T, Ogborne K, Loetscher M, Gladue R, et al. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J Exp Med. 1998;187:2009-21 pubmed
  3. Yang D, Chen Q, Hoover D, Staley P, Tucker K, Lubkowski J, et al. Many chemokines including CCL20/MIP-3alpha display antimicrobial activity. J Leukoc Biol. 2003;74:448-55 pubmed
  4. Booth V, Clark Lewis I, Sykes B. NMR structure of CXCR3 binding chemokine CXCL11 (ITAC). Protein Sci. 2004;13:2022-8 pubmed
    b>CXCL11 (ITAC) is one of three chemokines known to bind the receptor CXCR3, the two others being CXCL9 (Mig) and CXCL10 (IP-10)...
  5. Li Z, Gu J, Zhu Q, Liu J, Lu H, Lu Y, et al. Obese donor mice splenocytes aggravated the pathogenesis of acute graft-versus-host disease via regulating differentiation of Tregs and CD4+ T cell induced-type I inflammation. Oncotarget. 2017;8:74880-74896 pubmed publisher
    ..of obese donor splenocytes to migrate into target organs, such as IL-2, IL-17, IFN-?, TNF-?, CXCR3, CXCL9, CXCL10, CXCL11 and CCL3...
  6. Danikowski K, Jayaraman S, Prabhakar B. Regulatory T cells in multiple sclerosis and myasthenia gravis. J Neuroinflammation. 2017;14:117 pubmed publisher
    ..Likewise, strategies which affect Treg migration involve chemokines CCL17 and CXCL11. In pre-clinical animal models of experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune ..
  7. Johnstone S, Barsova J, Campos I, Frampton A. Equine herpesvirus type 1 modulates inflammatory host immune response genes in equine endothelial cells. Vet Microbiol. 2016;192:52-59 pubmed publisher
    ..gene expression showed that a subset of pro-inflammatory cytokines, including the CXCR3 ligands CXCL9, CXCL10, and CXCL11, as well as CCL5, IL-6 and TNF-? were consistently up-regulated in endothelial cells infected with each EHV-1 ..
  8. Yeruva L, Spencer N, Saraf M, Hennings L, Bowlin A, Cleves M, et al. Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model. BMC Gastroenterol. 2016;16:40 pubmed publisher
    ..In ileum, formula diet induced significant up-regulation of AMCFII, IL-8, IL-15, VEGFA, LIF, FASL, CXCL11, CCL4, CCL25 and down-regulation of IL-6, IL-9, IL-10, IL-27, IFNA4, CSF3, LOC100152038, and LOC100736831 at the ..
  9. Lin T, Walker G, Kurji K, Fang E, Law G, Prasad S, et al. Parainflammation associated with advanced glycation endproduct stimulation of RPE in vitro: implications for age-related degenerative diseases of the eye. Cytokine. 2013;62:369-81 pubmed publisher
    ..Levels of mRNA of chemokine, CXCL11, and viperin, RSAD2, were up-regulated and may play a role in driving the inflammatory response via the NF-kB and ..

More Information

Publications131 found, 100 shown here

  1. Sohn C, Lee A, Qiao Y, Loupasakis K, Ivashkiv L, Kalliolias G. Prolonged tumor necrosis factor α primes fibroblast-like synoviocytes in a gene-specific manner by altering chromatin. Arthritis Rheumatol. 2015;67:86-95 pubmed publisher
    ..pre-exposure of FLS to TNFα enhanced the magnitude and extended the kinetics of CXCL10/IP-10, CXCL9, and CXCL11 production upon subsequent IFN stimulation...
  2. Hawley K, Cruz A, Benjamin S, La Vake C, Cervantes J, Ledoyt M, et al. IFN? Enhances CD64-Potentiated Phagocytosis of Treponema pallidum Opsonized with Human Syphilitic Serum by Human Macrophages. Front Immunol. 2017;8:1227 pubmed publisher
    ..of cytokines, macrophage activation markers (CD40, CD80), TLRs (TLR2, TLR7, TLR8), chemokines (CCL19, CXCL10, CXCL11), and TH1-promoting cytokines (IL-12, IL-15)...
  3. Li J, Shen X, Shao J, Tao M, Gu J, Li J, et al. The total alkaloids from Coptis chinensis Franch improve cognitive deficits in type 2 diabetic rats. Drug Des Devel Ther. 2018;12:2695-2706 pubmed publisher
    ..These findings conclude that TAC prevents diabetic cognitive deficits, most likely by ameliorating the disorder of glucose and lipid metabolism, attenuating Aβ deposition, and enhancing insulin signaling. ..
  4. Lefaucheur C, Viglietti D, Hidalgo L, Ratner L, Bagnasco S, Batal I, et al. Complement-Activating Anti-HLA Antibodies in Kidney Transplantation: Allograft Gene Expression Profiling and Response to Treatment. J Am Soc Nephrol. 2018;29:620-635 pubmed publisher
    ..cells and monocytes/macrophages in capillaries and increased expression of five biologically relevant genes (CXCL11, CCL4, MS4A7, MS4A6A, and FCGR3A) indicative of endothelial activation, IFNγ
  5. Borjini N, Fernández M, Giardino L, Calzà L. Cytokine and chemokine alterations in tissue, CSF, and plasma in early presymptomatic phase of experimental allergic encephalomyelitis (EAE), in a rat model of multiple sclerosis. J Neuroinflammation. 2016;13:291 pubmed
    ..MAL, MBP, and PMP22 while an opposite expression profile was observed for inflammation-related genes, such as CXCL11 and CXCL10...
  6. Song G, Lu Q, Fan H, Zhang X, Ge L, Tian R, et al. Inhibition of hexokinases holds potential as treatment strategy for rheumatoid arthritis. Arthritis Res Ther. 2019;21:87 pubmed publisher
    ..or LND treatment decreased the production of pro-inflammatory factors, such as IL-6, IL-8, CXCL9, CXCL10, and CXCL11, and cell viability, but induced cell apoptosis of RASFs...
  7. Jeong Y, Hur Y, Lee H, Kim S, Cho J, Chang J, et al. Discrimination between active and latent tuberculosis based on ratio of antigen-specific to mitogen-induced IP-10 production. J Clin Microbiol. 2015;53:504-10 pubmed publisher
  8. Angiolilli C, Kabala P, Grabiec A, Van Baarsen I, Ferguson B, Garcia S, et al. Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes. Ann Rheum Dis. 2017;76:277-285 pubmed publisher HDAC3/6i resulted in reduced expression of a subset of IFN-dependent genes, including the chemokines CXCL9 and CXCL11. Inhibition of HDAC3 in RA FLS largely recapitulates the effects of pan-HDACi in suppressing inflammatory gene ..
  9. Hsiao J, Ng B, Smits M, Wang J, Jasavala R, Martinez H, et al. Androgen receptor and chemokine receptors 4 and 7 form a signaling axis to regulate CXCL12-dependent cellular motility. BMC Cancer. 2015;15:204 pubmed publisher
    ..Moreover, luciferase assays and quantitative polymerase chain reaction (qPCR) were used to study how chemokines CXCL11 and CXCL12 regulate androgen-regulated genes (ARGs) in LNCaP prostate-tumor cells...
  10. da Silva Antunes R, Madge L, Soroosh P, Tocker J, Croft M. The TNF Family Molecules LIGHT and Lymphotoxin αβ Induce a Distinct Steroid-Resistant Inflammatory Phenotype in Human Lung Epithelial Cells. J Immunol. 2015;195:2429-41 pubmed publisher
    ..tested, namely the adhesion molecules ICAM-1 and VCAM-1; the chemokines CCL5, CCL20, CXCL1, CXCL3, CXCL5, and CXCL11; the cytokines IL-6, activin A and GM-CSF; and metalloproteinases matrix metalloproteinase-9 and a disintegrin and ..
  11. Budczies J, Denkert C, Gyorffy B, Schirmacher P, Stenzinger A. Chromosome 9p copy number gains involving PD-L1 are associated with a specific proliferation and immune-modulating gene expression program active across major cancer types. BMC Med Genomics. 2017;10:74 pubmed publisher
    ..Among these were specific cytokines and chemokines, e.g. CCL4, CCL8, CXCL10, CXCL11, other immunoregulatory genes such as IFN-G and IDO1 as well as highly expressed proliferation-related kinases and ..
  12. Aouadi W, Blanjoie A, Vasseur J, Debart F, Canard B, Decroly E. Binding of the Methyl Donor S-Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2'-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10. J Virol. 2017;91: pubmed publisher
    ..the RNA binding groove (K46, K170, E203, D133, R38, Y47, and Y181) and the cap-0 binding site (Y30, Y132, and H174)...
  13. Tran T, Cousin F, Lynch D, Menon R, Brulc J, Brown J, et al. Prebiotic supplementation in frail older people affects specific gut microbiota taxa but not global diversity. Microbiome. 2019;7:39 pubmed publisher
    ..Clostridium cluster IV), Parabacteroides, Phascolarctobacterium, increased, and levels of the chemokine CXCL11 were significantly lower in the frail elderly group, but increased during the wash-out period...
  14. Liu C, Cheng Z, Wang Y, Dai X, Zhang J, Xue D. Paeoniflorin exerts a nephroprotective effect on concanavalin A-induced damage through inhibition of macrophage infiltration. Diagn Pathol. 2015;10:120 pubmed publisher
    ..Immunofluorescence microscopy demonstrated CXCR3 bound tightly to C-X-C motif ligand 11 (CXCL11) in the kidneys of the conA-vehicle mice and showed that PF treatment could suppress CXCR3/CXCL11 over-activation...
  15. Hosokawa I, Hosokawa Y, Ozaki K, Yumoto H, Nakae H, Matsuo T. Proinflammatory effects of muramyldipeptide on human gingival fibroblasts. J Periodontal Res. 2010;45:193-9 pubmed publisher
    ..Production of interleukin (IL)-6, IL-8, cc chemokine ligand2, cxc chemokine ligand10 (CXCL10) and CXCL11 from HGFs was examined by enzyme-linked immunosorbent assay (ELISA)...
  16. Ohkuri T, Kosaka A, Ishibashi K, Kumai T, Hirata Y, Ohara K, et al. Intratumoral administration of cGAMP transiently accumulates potent macrophages for anti-tumor immunity at a mouse tumor site. Cancer Immunol Immunother. 2017;66:705-716 pubmed publisher
    ..of tumor necrosis factor alpha TNF?), and high expression levels of T cell-recruiting chemokines, Cxcl10 and Cxcl11, IFN-induced molecules, MX dynamin-like GTPase 1 (Mx1) and 2'-5' oligoadenylate synthetase-like 1 (Oasl1), nitric ..
  17. Han X, Parker T. Anti-inflammatory activity of clove (Eugenia caryophyllata) essential oil in human dermal fibroblasts. Pharm Biol. 2017;55:1619-1622 pubmed publisher
    ..This study provides important evidence of CEO-induced anti-inflammatory and tissue remodelling activity in human dermal fibroblasts. This study also supports the anticancer properties of CEO and its major active component eugenol. ..
  18. Marth C, Firestone S, Glenton L, Browning G, Young N, Krekeler N. Oestrous cycle-dependent equine uterine immune response to induced infectious endometritis. Vet Res. 2016;47:110 pubmed
    ..NOD-like receptor NLRC5, tissue inhibitor of metallopeptidases 1 (TIMP1) and chemokines CCL2, CXCL9, CXCL10 and CXCL11 were all increased 3 h after inoculation of E. coli compared to levels detected prior to inoculation...
  19. Febvre James M, Lecureur V, Augagneur Y, Mayati A, Fardel O. Repression of interferon ?-regulated cytokines by the JAK1/2 inhibitor ruxolitinib in inflammatory human macrophages. Int Immunopharmacol. 2018;54:354-365 pubmed publisher
    ..Other repressed cytokines included IL27 and the chemokines CCL2, CXCL9, CXCL10 and CXCL11, but not IL1?...
  20. Maliniemi P, Hahtola S, Ovaska K, Jeskanen L, Väkevä L, Jäntti K, et al. Molecular characterization of subcutaneous panniculitis-like T-cell lymphoma reveals upregulation of immunosuppression- and autoimmunity-associated genes. Orphanet J Rare Dis. 2014;9:160 pubmed publisher
    ..e. IFNG, CXCR3, CXCL9, CXCL10, CXCL11, and CCL5), were also significantly increased...
  21. Taraseviciute A, Tkachev V, Ponce R, Turtle C, Snyder J, Liggitt H, et al. Chimeric Antigen Receptor T Cell-Mediated Neurotoxicity in Nonhuman Primates. Cancer Discov. 2018;8:750-763 pubmed publisher
    ..i>Cancer Discov; 8(6); 750-63. ©2018 AACR.This article is highlighted in the In This Issue feature, p. 663. ..
  22. Olsen I, Taubman M, Singhrao S. Porphyromonas gingivalis suppresses adaptive immunity in periodontitis, atherosclerosis, and Alzheimer's disease. J Oral Microbiol. 2016;8:33029 pubmed publisher
    ..The suppression of IFN-?-stimulated release of interferon-inducible protein-10 (IP-10) chemokine ligands [ITAC (CXCL11) and Mig (CXCL9)] by P...
  23. George T, Bell M, Chakraborty M, Siderovski D, Giembycz M, Newton R. Protective Roles for RGS2 in a Mouse Model of House Dust Mite-Induced Airway Inflammation. PLoS ONE. 2017;12:e0170269 pubmed publisher
    ..Likewise, cytokine and chemokine (IL4, IL17, IL5, LIF, IL6, CSF3, CXCLl, CXCL10 and CXCL11) release was increased by HDM exposure...
  24. O Halloran E, Curtis B, Afshar M, Chen M, Kovacs E, Burnham E. Alveolar macrophage inflammatory mediator expression is elevated in the setting of alcohol use disorders. Alcohol. 2016;50:43-50 pubmed publisher
    ..05). AUD subjects had 5-fold higher levels of CXCL11 mRNA expression (p < 0.05) and a 2.4-fold increase in IL-6 mRNA expression by RT-PCR as well...
  25. Li Z, Levast B, Madrenas J. Staphylococcus aureus Downregulates IP-10 Production and Prevents Th1 Cell Recruitment. J Immunol. 2017;198:1865-1874 pubmed publisher
    ..g., CXCL9 and CXCL11). These effects translated into inhibition of superantigen-induced Th1 cell recruitment...
  26. Van Raemdonck K, Van Den Steen P, Liekens S, Van Damme J, Struyf S. CXCR3 ligands in disease and therapy. Cytokine Growth Factor Rev. 2015;26:311-27 pubmed publisher
    ..The CXCR3 ligands, activating both receptor variants, include CXCL4, CXCL4L1, CXCL9, CXCL10 and CXCL11. Upon CXCR3A activation these ELR-negative CXC chemokines mediate chemotactic and proliferative responses, for ..
  27. Ruebel M, Shankar K, Gaddy D, Lindsey F, BADGER T, Andres A. Maternal obesity is associated with ovarian inflammation and upregulation of early growth response factor 1. Am J Physiol Endocrinol Metab. 2016;311:E269-77 pubmed publisher
    ..expression of glucose transporters GLUT4 and GLUT9 and elevation of proinflammatory genes, including CCL2, CXCL10, CXCL11, CCR2, CXCR1, and TNFα in ovaries from OB compared with LN (P < 0.05)...
  28. Cossu M, van Bon L, Preti C, Rossato M, Beretta L, Radstake T. Earliest Phase of Systemic Sclerosis Typified by Increased Levels of Inflammatory Proteins in the Serum. Arthritis Rheumatol. 2017;69:2359-2369 pubmed publisher
    ..The results showed that CXCL10, CXCL11, tumor necrosis factor receptor type II (TNFRII), and chitinase 3-like protein 1 levels were significantly ..
  29. Altara R, Mallat Z, Booz G, Zouein F. The CXCL10/CXCR3 Axis and Cardiac Inflammation: Implications for Immunotherapy to Treat Infectious and Noninfectious Diseases of the Heart. J Immunol Res. 2016;2016:4396368 pubmed
    ..also couples to anti-inflammatory signaling and immunosuppressive regulatory T cell formation when activated by CXCL11. Numbers and functionality of regulatory T cells are reduced in patients with cardiac inflammation, supporting the ..
  30. Loos T, Mortier A, Gouwy M, Ronsse I, Put W, Lenaerts J, et al. Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. Blood. 2008;112:2648-56 pubmed publisher
    ..PAD was also able to convert CXCL11, causing an impairment of CXCR3 signaling and T-cell activation, though less pronounced than for CXCL10...
  31. Dyer D, SALANGA C, Volkman B, Kawamura T, Handel T. The dependence of chemokine-glycosaminoglycan interactions on chemokine oligomerization. Glycobiology. 2016;26:312-26 pubmed publisher
    ..In this study, several differentially oligomerizing chemokines (CCL2, CCL3, CCL5, CCL7, CXCL4, CXCL8, CXCL11 and CXCL12) and select oligomerization-deficient mutants were systematically characterized by surface plasmon ..
  32. Chawes B. Low-grade disease activity in early life precedes childhood asthma and allergy. Dan Med J. 2016;63: pubmed
    ..High levels of the Th2-related chemokine CCL22 and high CCL22/CXCL11 ratio were positively correlated with total IgE level during preschool age (II)...
  33. Johansen C, Rittig A, Mose M, Bertelsen T, Weimar I, Nielsen J, et al. STAT2 is involved in the pathogenesis of psoriasis by promoting CXCL11 and CCL5 production by keratinocytes. PLoS ONE. 2017;12:e0176994 pubmed publisher
    ..Gene silencing of STAT2 by siRNA in human keratinocytes revealed that upon IFNα stimulation CXCL11 and CCL5 were the only two cytokines, among 102 analyzed, found to be regulated through a STAT2-dependent ..
  34. Jacobs K, Collins Racie L, Colbert M, Duckett M, Golden Fleet M, Kelleher K, et al. A genetic selection for isolating cDNAs encoding secreted proteins. Gene. 1997;198:289-96 pubmed
    ..Since signal sequences possess features conserved throughout evolution, the procedure can be used to isolate genes encoding secreted proteins from both eukaryotes and prokaryotes. ..
  35. Walters M, Ebsworth K, Berahovich R, Penfold M, Liu S, Al Omran R, et al. Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats. Br J Cancer. 2014;110:1179-88 pubmed publisher
    ..In human GBM, CXCR7 expression increased with glioma grade and was spatially associated with CXCL12 and CXCL11/I-TAC...
  36. Mortier A, Gouwy M, Van Damme J, Proost P, Struyf S. CD26/dipeptidylpeptidase IV-chemokine interactions: double-edged regulation of inflammation and tumor biology. J Leukoc Biol. 2016;99:955-69 pubmed publisher
    ..A large number of human chemokines, including CXCL2, CXCL6, CXCL9, CXCL10, CXCL11, CXCL12, CCL3L1, CCL4, CCL5, CCL11, CCL14, and CCL22, are cleaved by CD26; however, the efficiency is clearly ..
  37. Cao Y, Huang H, Wang Z, Zhang G. The Inflammatory CXC Chemokines, GRO?high, IP-10low, and MIGlow, in Tumor Microenvironment Can Be Used as New Indicators for Non-small Cell Lung Cancer Progression. Immunol Invest. 2017;46:361-374 pubmed publisher
    ..In summary, tumor tissue-infiltrating CXC chemokines, GRO?high, IP-10low, and MIGlow in the tumor microenvironment can be used as potential indicators for the progression of NSCLC. ..
  38. Rossios C, Pavlidis S, Gibeon D, Mumby S, Durham A, Ojo O, et al. Impaired innate immune gene profiling in airway smooth muscle cells from chronic cough patients. Biosci Rep. 2017;37: pubmed publisher
    ..The top up-regulated genes included chemokine (C-X-C motif) ligand (CXCL) 11 (CXCL11), CXCL10, chemokine (C-C motif) ligand (CCL) 5 (CCL5) and interferon-induced protein 44 like (..
  39. Kanai K, Park A, Watanabe A, Arikawa T, Yasui T, Yoshida H, et al. Murine γ-Herpesvirus 68 Induces Severe Lung Inflammation in IL-27-Deficient Mice with Liver Dysfunction Preventable by Oral Neomycin. J Immunol. 2018;200:2703-2713 pubmed publisher
    ..Infiltration of IFN-γ-producing effector cells and upregulation of the CXCR3 ligand chemokines CXCL9, CXCL10, and CXCL11 were noted in the liver of MHV68-infected mice...
  40. Ajami K, Pitman M, Wilson C, Park J, Menz R, Starr A, et al. Stromal cell-derived factors 1alpha and 1beta, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8. FEBS Lett. 2008;582:819-25 pubmed publisher
    ..We report DP8 cleavage of the N-terminal two residues of IP10 (CXCL10), ITAC (CXCL11) and SDF-1 (CXCL12). This has implications for DP8 substrate specificity...
  41. Miekus K, Jarocha D, Trzyna E, Majka M. Role of I-TAC-binding receptors CXCR3 and CXCR7 in proliferation, activation of intracellular signaling pathways and migration of various tumor cell lines. Folia Histochem Cytobiol. 2010;48:104-11 pubmed publisher
    ..Our data suggest an important role of I-TAC and its receptors in biology of solid tumors and we postulate that I-TAC-binding receptors might be used as the potential targets for antitumor therapy. ..
  42. Bodnar R, Wells A. Differential regulation of pericyte function by the CXC receptor 3. Wound Repair Regen. 2015;23:785-96 pubmed publisher
    ..Pericyte stimulation with the CXCR3 ligands Mig (CXCL9), IP-9/I-TAC (CXCL11), or IP-10 (CXCL10) resulted in the activation of ERK but not AKT...
  43. Zhu Y, Wang Z, Zhu Y, Wang J, Cai L, Shen H, et al. [CXCR3 monoclonal antibody inhibits the proliferation and migration of MCF-7 cells and HepG2 cells in vitro]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015;31:1544-8 pubmed
    ..CXCR3 mAb can significantly inhibit the proliferation and migration of the tumor cells highly expressing CXCR3 in vitro. ..
  44. Semenov A, Arsentieva N, Lubimova N, Tulienev S, Basina V, Esaulenko E, et al. [THE ROLE OF CYTOKINES AND CHEMOKINES IN LABORATORY DIAGNOSTIC OF CHRONIC VIRAL HEPATITIS C]. Klin Lab Diagn. 2015;60:45-51 pubmed
    ..The increasing of level of TNFα, CCL2/MCP-1, CCL4/ MIP-l, CCL8/ACP-2, CCL20/MIP-3α, CXCL9/MIG, CXCL10/IP-10, CXCL11/ITA C was established in blood plasma of patients with chronic viral hepatitis C as compared with control group...
  45. Shrivastava S, Meissner E, Funk E, Poonia S, Shokeen V, Thakur A, et al. Elevated hepatic lipid and interferon stimulated gene expression in HCV GT3 patients relative to non-alcoholic steatohepatitis. Hepatol Int. 2016;10:937-946 pubmed
    ..Genes with significantly higher expression in HCV included chemokines CXCL10, CXCL11 interferon IFNA2, interferon receptors IFNAR1, IL10RB negative regulators of interferon signaling SOCS3, USP18, ..
  46. Liu Z, Wang M, Zhou S, Ma J, Shi Y, Peng J, et al. Pulsed high-dose dexamethasone modulates Th1-/Th2-chemokine imbalance in immune thrombocytopenia. J Transl Med. 2016;14:301 pubmed
    ..Plasma levels of CCL5 and CXCL11 (Th1-associated) and of CCL11 (Th2-associated) were determined by ELISA...
  47. Ren X, Liu W, Liu Y. Effects of fluconazole on the clinical outcome and immune response in fungal co-infected tuberculosis patients. Microb Pathog. 2018;117:148-152 pubmed publisher
    ..interferon (IFN)-?, tumor necrosis factor (TNF)-? and chemokines chemokine C-X-C motif ligand (CXCL)9, CXCL10, CXCL11 were determined with enzyme-linked immunosorbent assay kits...
  48. Chedraui P, Solís E, Pérez López F, Schatz F, Kayisli U, Escobar G, et al. Umbilical cord plasma interferon-induced protein 10 (IP-10) and interferon-induced T-cell alpha chemoattractant (ITAC) levels are lower in women with severe preeclampsia. J Perinat Med. 2016;44:291-4 pubmed publisher
  49. Kabasawa M, Sugaya M, Oka T, Takahashi N, Kawaguchi M, Suga H, et al. Decreased interleukin-21 expression in skin and blood in advanced mycosis fungoides. J Dermatol. 2016;43:819-22 pubmed publisher MF lesional skin significantly correlated with those of T-helper type-1 cytokines/chemokines such as CXCL10, CXCL11 and γ-interferon. Immunohistochemistry showed that IL-21 was expressed by keratinocytes in patch and plaque MF...
  50. Yoon M, Pham C, Phan M, Shin D, Jang Y, Park M, et al. Irradiation of breast cancer cells enhances CXCL16 ligand expression and induces the migration of natural killer cells expressing the CXCR6 receptor. Cytotherapy. 2016;18:1532-1542 pubmed publisher
    ..Related chemokine ligands (CXCL11, CXCL12 and CXCL16) in human breast cancer cell lines (MCF7, SKBR3 and MDA-MB231) irradiated at various doses were ..
  51. Garcia M, Qu Y, Scholte C, O Connor D, Rounds W, Moyes K. Regulatory effect of dietary intake of chromium propionate on the response of monocyte-derived macrophages from Holstein cows in mid lactation. J Dairy Sci. 2017;100:6389-6399 pubmed publisher
    ..Expression of IGFI was increased in MDM-M0, and expression of CXCL11 tended to increase in MDM-M2 from cows fed CrP compared with cows fed CTL...
  52. Salmaggi A, Gelati M, Dufour A, Corsini E, Pagano S, Baccalini R, et al. Expression and modulation of IFN-gamma-inducible chemokines (IP-10, Mig, and I-TAC) in human brain endothelium and astrocytes: possible relevance for the immune invasion of the central nervous system and the pathogenesis of multiple sclerosis. J Interferon Cytokine Res. 2002;22:631-40 pubmed
    ..Our data highlight the capability of cells of the CNS to activate the chemoattractant machinery in a proinflammatory environment and in MS. ..
  53. Yates C, Whaley D, Y Chen A, Kulesekaran P, Hebda P, Wells A. ELR-negative CXC chemokine CXCL11 (IP-9/I-TAC) facilitates dermal and epidermal maturation during wound repair. Am J Pathol. 2008;173:643-52 pubmed publisher
    ..equivalently binds four different ELR-devoid CXC chemokines (ie, PF4/CXCL4, IP-10/CXCL10, MIG/CXCL9, and IP-9/CXCL11), we sought to identify the ligand that coordinates epidermal coverage with the maturation of the underlying ..
  54. Antonelli A, Fallahi P, Ferrari S, Corrado A, Sebastiani M, Giuggioli D, et al. Parallel increase of circulating CXCL11 and CXCL10 in mixed cryoglobulinemia, while the proinflammatory cytokine IL-6 is associated with high serum Th2 chemokine CCL2. Clin Rheumatol. 2013;32:1147-54 pubmed publisher
    ..levels of interelukin (IL)-1?, IL-6 and tumor necrosis factor (TNF)-?, chemokine (C-X-C motif) ligand (CXCL)10, CXCL11 and chemokine (C-C motif) ligand (CCL)2 in "mixed cryoglobulinemia and hepatitis C" (MC?+?HCV)...
  55. Kennedy R, Poland G, Ovsyannikova I, Oberg A, Asmann Y, Grill D, et al. Impaired innate, humoral, and cellular immunity despite a take in smallpox vaccine recipients. Vaccine. 2016;34:3283-90 pubmed publisher
    ..testing indicated these low responders had a diminished innate antiviral gene expression pattern (IFNA1, CXCL10, CXCL11, OASL) upon in vitro stimulation with vaccinia virus, perhaps indicative of a dysregulated innate response...
  56. Bracaglia C, de Graaf K, Pires Marafon D, Guilhot F, Ferlin W, Prencipe G, et al. Elevated circulating levels of interferon-? and interferon-?-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis. Ann Rheum Dis. 2017;76:166-172 pubmed publisher assess serum levels of interleukin (IL)-1?, IL-6, IFN? and of the IFN?-induced chemokines CXCL9, CXCL10 and CXCL11 in patients with sec-HLH (n=11) and in patients with sJIA (n=54), of whom 20 had active MAS at sampling...
  57. Loetscher P, Pellegrino A, Gong J, Mattioli I, Loetscher M, Bardi G, et al. The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3. J Biol Chem. 2001;276:2986-91 pubmed
    ..These results suggest that chemokines that attract Th1 cells via CXCR3 can concomitantly block the migration of Th2 cells in response to CCR3 ligands, thus enhancing the polarization of T cell recruitment. ..
  58. Lambeir A, Proost P, Durinx C, Bal G, Senten K, Augustyns K, et al. Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family. J Biol Chem. 2001;276:29839-45 pubmed
    ..catalytic parameters for a relevant selection of chemokines (CCL3b, CCL5, CCL11, CCL22, CXCL9, CXCL10, CXCL11, and CXCL12) previously reported to alter their chemotactic behavior due to CD26/dipeptidyl peptidase IV-catalyzed ..
  59. Larsson A, Carlsson L, Gordh T, Lind A, Thulin M, Kamali Moghaddam M. The effects of age and gender on plasma levels of 63 cytokines. J Immunol Methods. 2015;425:58-61 pubmed publisher
    ..05), and 15 of the biomarkers (CCL11, CCL25, CDCP1, CSF-1, CXCL11, CXCL9, FGF-23, Flt3L, HGF, IL-10RB, MCP-3, MCP-4, MMP-10, OPG, VEGF-A) were significantly associated with age...
  60. Kim H, Park J, Lee S, Kim K, Park K, Chung W. Loss of RUNX3 expression promotes cancer-associated bone destruction by regulating CCL5, CCL19 and CXCL11 in non-small cell lung cancer. J Pathol. 2015;237:520-31 pubmed publisher
    ..RANKL/OPG ratio and found that RUNX3 knockdown led to CCL5 up-regulation and down-regulation of CCL19 and CXCL11 in NSCLC cells...
  61. Bretz C, Savage S, Capozzi M, Suarez S, Penn J. NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis. Sci Rep. 2015;5:14963 pubmed publisher
    ..measured using protein ELISAs and conditioned cell culture medium, and showed that NFATc4 siRNA reduced CXCL10, CXCL11, and MCP-1 protein levels...
  62. Xu J, Chen M, He L, Zhang S, Ding T, Yao H, et al. Isolation and characterization of a T4-like phage with a relatively wide host range within Escherichia coli. J Basic Microbiol. 2016;56:405-21 pubmed publisher
    ..However, it also showed some unique features, for example, ORF142 and ORF143, which encode IP9 and IP8, respectively, and may counteract host resistance only exist in a few T4-like phages such as IME08 and ..
  63. McKay H, Bream J, Margolick J, Martinez Maza O, Phair J, Rinaldo C, et al. Host factors associated with serologic inflammatory markers assessed using multiplex assays. Cytokine. 2016;85:71-9 pubmed publisher
    ..Serum concentrations of twenty-three biomarkers, including C-reactive protein (CRP), cytokines (CXCL11, CXCL8, CXCL10, CCL2, CCL13, CCL4, CCL17, CXCL13, IL-10, IL-12p70, IL-6, TNF-?, IL-2, IFN-?, IL-1?, GM-CSF, BAFF), ..
  64. Burke S, Karlstad M, Eder A, Regal K, Lu D, Burk D, et al. Pancreatic ?-Cell production of CXCR3 ligands precedes diabetes onset. Biofactors. 2016;42:703-715 pubmed publisher
    ..cell exposure to IFN-?, with subsequent occupancy at proximal and distal response elements within the Cxcl9 and Cxcl11 gene promoters. This increase in STAT1 binding is coupled to the rapid appearance of chemokine transcript...
  65. Li Z, Gu J, Liu J, Zhu Q, Lu H, Lu Y, et al. Chitinase 3-like-1 deficient donor splenocytes accentuated the pathogenesis of acute graft-versus-host diseases through regulating T cell expansion and type I inflammation. Int Immunopharmacol. 2017;46:201-209 pubmed publisher
    ..splenocytes to migrate into target organs and produce Th1-related cytokines and chemokines, such as CXCL9, CXCL11, IFN-? and TNF-?...
  66. Huang S, Feng C, Chen L, Huang Z, Zhou X, Li B, et al. Molecular Mechanisms of Mild and Severe Pneumonia: Insights from RNA Sequencing. Med Sci Monit. 2017;23:1662-1673 pubmed
    ..CONCLUSIONS S100A9 and S100A12 may have a role in the pathogenesis of pneumonia: S100A9 and CXCL1 may contribute solely in mild pneumonia, and CCL5 and CXCL11 may contribute in severe pneumonia.
  67. Li H, Zhao X, Wang J, Zong M, Yang H. Bioinformatics analysis of gene expression profile data to screen key genes involved in pulmonary sarcoidosis. Gene. 2017;596:98-104 pubmed publisher
    ..In the PPI network constructed by STRING database, CXCL9, STAT1, CCL5, CXCL11 and GBP1 had higher degrees and betweenness values, and could interact with each other...
  68. Hensbergen P, van der Raaij Helmer E, Dijkman R, van der Schors R, Werner Felmayer G, Boorsma D, et al. Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity. Eur J Biochem. 2001;268:4992-9 pubmed
    ..In addition we identified a C-terminally truncated CXCL10, lacking the last four amino acids. Native CXCL11 was primarily found in its intact mature form but we also found a mass corresponding to an N-terminally truncated ..
  69. Lasagni L, Francalanci M, Annunziato F, Lazzeri E, Giannini S, Cosmi L, et al. An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. J Exp Med. 2003;197:1537-49 pubmed
    The chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC regulate lymphocyte chemotaxis, mediate vascular pericyte proliferation, and act as angiostatic agents, thus inhibiting tumor growth...
  70. Tacke F, Zimmermann H, Berres M, Trautwein C, Wasmuth H. Serum chemokine receptor CXCR3 ligands are associated with progression, organ dysfunction and complications of chronic liver diseases. Liver Int. 2011;31:840-9 pubmed publisher
    ..of the CXCR3 ligands, CXCL9 (monokine induced by interferon-?), CXCL10 (interferon-?-inducible protein 10) and CXCL11 (interferon-inducible T cell ? chemo-attractant) in healthy controls (n=53), subjects with histologically ..
  71. Antonelli A, Fallahi P, Ferrari S, Sebastiani M, Manfredi A, Mazzi V, et al. Circulating CXCL11 and CXCL10 are increased in hepatitis C-associated cryoglobulinemia in the presence of autoimmune thyroiditis. Mod Rheumatol. 2012;22:659-67 pubmed publisher
    No data are available about circulating levels of the CXCL11 chemokine in hepatitis C virus (HCV)-associated mixed cryoglobulinemia (MC) patients with or without autoimmune thyroiditis (AT)...
  72. Antonelli A, Fallahi P, Ferrari S, Frascerra S, Mancusi C, Colaci M, et al. High circulating chemokines (C-X-C motif) ligand 9, and (C-X-C motif) ligand 11, in hepatitis C-associated cryoglobulinemia. Int J Immunopathol Pharmacol. 2013;26:49-57 pubmed
    C-X-C motif) ligand 9 and (C-X-C motif) ligand 11 (CXCL9 and CXCL11), are potent chemoattractants for activated T cells, and play an important role in T helper 1 (Th)1 cell recruitment in chronic hepatitis C...
  73. Kutty R, Samuel W, Abay R, Cherukuri A, Nagineni C, Duncan T, et al. Resveratrol attenuates CXCL11 expression induced by proinflammatory cytokines in retinal pigment epithelial cells. Cytokine. 2015;74:335-8 pubmed publisher
    ..RPE cells adjacent to drusen deposits in the AMD eye are known to contain CXCL11, a chemokine involved in inflammatory cell recruitment...
  74. Altara R, Gu Y, Struijker Boudier H, Thijs L, Staessen J, Blankesteijn W. Left Ventricular Dysfunction and CXCR3 Ligands in Hypertension: From Animal Experiments to a Population-Based Pilot Study. PLoS ONE. 2015;10:e0141394 pubmed publisher
    ..In conclusion, congruent with the concept that inflammation plays a key role in the pathogenesis of LV dysfunction, MIG, IP10 and I-TAC add diagnostic accuracy over and beyond NT-pro BNP. ..
  75. Gmiterek A, Kłopot A, Wojtowicz H, Trindade S, Olczak M, Olczak T. Immune response of macrophages induced by Porphyromonas gingivalis requires HmuY protein. Immunobiology. 2016;221:1382-1394 pubmed publisher
    ..cytokines (IL-1?, IL-6, TNF?), anti-inflammatory cytokine (IL-10), and chemokines (CCL3L1, CCL4, CXCL10, CXCL11, PTX3). P...
  76. Raucci R, Polo A, Budillon A, Colonna G, Costantini S. Conformational analysis of the human chemokine receptor CXCR3. Mol Immunol. 2017;92:76-86 pubmed publisher
    ..Furthermore, we modeled the CXCR3/CXCL11 complex, where CXCL11 is one of its natural ligands...
  77. Hochane M, Raison D, Coquard C, Béraud C, Bethry A, Danilin S, et al. Parathyroid hormone-related protein modulates mice mesangial cells inflammation and blunts apoptosis by enhancing Cox-2 expression. Am J Physiol Cell Physiol. 2017;:ajpcell.00018.2017 pubmed publisher
    ..also stimulated sustained expression (2-4 h) of chemokines, mainly RANTES/CCL5 and MIP-2/CXCL2, TARC/CCL17, I-TAC/CXCL11. Moreover, PTHrP markedly enhanced Cox-2 expression and elicited its auto-induction through the activation of the ..
  78. Kistner L, Doll D, Holtorf A, Nitsche U, Janssen K. Interferon-inducible CXC-chemokines are crucial immune modulators and survival predictors in colorectal cancer. Oncotarget. 2017;8:89998-90012 pubmed publisher
    ..the clinical relevance and functional contribution of interferon-regulated CXC-chemokines CXCL9, CXCL10, and CXCL11, described as T-cells attractants...
  79. Tan K, Ong H, Yan Y, Liu J, Li C, Ong Y, et al. In Vitro Model of Fully Differentiated Human Nasal Epithelial Cells Infected with Rhinovirus Reveals Epithelium-Initiated Immune Responses. J Infect Dis. 2017;: pubmed publisher
    ..of inflammatory genes suggested predominant type-1 immunity signaling and recruitment, with secreted CXCL9, IP-10, CXCL11 and RANTES as likely initiators of airway inflammatory responses...
  80. Laich A, Meyer M, Werner E, Werner Felmayer G. Structure and expression of the human small cytokine B subfamily member 11 (SCYB11/formerly SCYB9B, alias I-TAC) gene cloned from IFN-gamma-treated human monocytes (THP-1). J Interferon Cytokine Res. 1999;19:505-13 pubmed
    ..of a third, recently identified member of this group named small inducible cytokine B subfamily member 11 (SCYB11, formerly SCYB9B) or IFN-inducible T cell alpha chemoattractant (I-TAC)...
  81. Kao J, Kobashigawa J, Fishbein M, MacLellan W, Burdick M, Belperio J, et al. Elevated serum levels of the CXCR3 chemokine ITAC are associated with the development of transplant coronary artery disease. Circulation. 2003;107:1958-61 pubmed
    ..Serum levels of chemokines were measured by ELISA. Levels of ITAC/CXCL11 were found to be elevated in patients with severe TCAD compared with long-term survivors of transplantation ..
  82. Helbig K, Ruszkiewicz A, Semendric L, Harley H, McColl S, Beard M. Expression of the CXCR3 ligand I-TAC by hepatocytes in chronic hepatitis C and its correlation with hepatic inflammation. Hepatology. 2004;39:1220-9 pubmed
  83. Ogawa N, Kawanami T, Shimoyama K, Ping L, Sugai S. Expression of interferon-inducible T cell alpha chemoattractant (CXCL11) in the salivary glands of patients with Sjögren's syndrome. Clin Immunol. 2004;112:235-8 pubmed
    To investigate the possible involvement of interferon-inducible T cell alpha chemoattractant (I-TAC or CXCL11) in the salivary gland lesions of Sjögren's syndrome (SS), I-TAC mRNA expression was assayed in cultured salivary epithelial ..
  84. Foley J, Yu C, Solow R, Yacobucci M, Peden K, Farber J. Roles for CXC chemokine ligands 10 and 11 in recruiting CD4+ T cells to HIV-1-infected monocyte-derived macrophages, dendritic cells, and lymph nodes. J Immunol. 2005;174:4892-900 pubmed
    ..Of the 12 chemokines analyzed, mRNAs for two, CXCL10 and CXCL11, ligands for the chemokine receptor CXCR3, were up-regulated in both cell types upon infection by HIV-1...
  85. Grygorczuk S, Zajkowska J, Swierzbinska R, Pancewicz S, Kondrusik M, Hermanowska Szpakowicz T. Concentration of interferon-inducible T cell chemoattractant and monocyte chemotactic protein-1 in serum and cerebrospinal fluid of patients with Lyme borreliosis. Rocz Akad Med Bialymst. 2005;50:173-8 pubmed
    ..The aim of the study was to evaluate synthesis of chemokines: interferon-induced T cell chemoattractant (I-TAC--chemoattractant for Th1 lymphocytes), and monocyte chemotactic protein (MCP-1) in Lyme borreliosis...
  86. Porter J, Falzon M, Hall A. Polarized localization of epithelial CXCL11 in chronic obstructive pulmonary disease and mechanisms of T cell egression. J Immunol. 2008;180:1866-77 pubmed
    ..across the bronchial epithelium is a multistep process, driven in part by a polarized transepithelial gradient of CXCL11 that is up-regulated in patients with chronic obstructive airways disease...
  87. Schroepf S, Kappler R, Brand S, Prell C, Lohse P, Glas J, et al. Strong overexpression of CXCR3 axis components in childhood inflammatory bowel disease. Inflamm Bowel Dis. 2010;16:1882-90 pubmed publisher
    ..As CXCL9, CXCL10, and CXCL11 are the 3 ligands to the receptor CXCR3, the aim of this study was to investigate the colonic transcriptional ..
  88. Gallo A, Saad A, Ali R, Dardik A, Tellides G, Geirsson A. Circulating interferon-?-inducible Cys-X-Cys chemokine receptor 3 ligands are elevated in humans with aortic aneurysms and Cys-X-Cys chemokine receptor 3 is necessary for aneurysm formation in mice. J Thorac Cardiovasc Surg. 2012;143:704-10 pubmed publisher
    ..The Cys-X-Cys chemokine receptor 3 receptor is necessary for vascular inflammation and the formation of arterial aneurysms in mice. ..
  89. Sfriso P, Cozzi F, Oliviero F, Caso F, Cardarelli S, Facco M, et al. CXCL11 in bronchoalveolar lavage fluid and pulmonary function decline in systemic sclerosis. Clin Exp Rheumatol. 2012;30:S71-5 pubmed
    ..It has been reported that IFN-? induces the production of CXCL11 in the lung and plasma of patients with lung-fibrosis...
  90. De Paepe B, Creus K, Martin J, De Bleecker J. Upregulation of chemokines and their receptors in Duchenne muscular dystrophy: potential for attenuation of myofiber necrosis. Muscle Nerve. 2012;46:917-25 pubmed publisher
    ..CXCL1, CXCL2, CXCL3, CXCL8, and CXCL11, absent from normal muscle fibers, were induced in DMD myofibers...
  91. Westernströer B, Langenstroth D, Kliesch S, Troppmann B, Redmann K, Macdonald J, et al. Developmental expression patterns of chemokines CXCL11, CXCL12 and their receptor CXCR7 in testes of common marmoset and human. Cell Tissue Res. 2015;361:885-98 pubmed publisher
    The chemokine receptor CXCR7 interacts with the chemokines CXCL11 and CXCL12. During development, this ligand receptor system (C-X-C) provokes cell-type-specific responses in terms of migration, adhesion or ligand sequestration...
  92. Westphal G, Rihs H, Schaffranek A, Zeiler T, Werfel T, Heratizadeh A, et al. A variant of the CXCL11 gene may influence susceptibility to contact allergy, particularly in polysensitized patients. Contact Dermatitis. 2016;75:303-307 pubmed publisher
    ..Fifteen genetic variants in 13 genes were analysed. The homozygous variant CXCL11 AA genotype (rs6817952) was significantly more frequent among polysensitized patients (10 of 239?=?4.2%; p?=?0...