CXCL10

Summary

Gene Symbol: CXCL10
Description: C-X-C motif chemokine ligand 10
Alias: IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine 10, 10 kDa interferon gamma-induced protein, chemokine (C-X-C motif) ligand 10, gamma IP10, interferon-inducible cytokine IP-10, protein 10 from interferon (gamma)-induced cell line, small inducible cytokine subfamily B (Cys-X-Cys), member 10, small-inducible cytokine B10
Species: human
Products:     CXCL10

Top Publications

  1. Clarke D, Clifford R, Jindarat S, Proud D, Pang L, Belvisi M, et al. TNF? and IFN? synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-?B, and the transcriptional coactivator CREB-binding protein. J Biol Chem. 2010;285:29101-10 pubmed publisher
    Asthmatic airway smooth muscle (ASM) expresses interferon-?-inducible protein-10 (CXCL10), a chemokine known to mediate mast cell migration into ASM bundles that has been reported in the airways of asthmatic patients...
  2. Shiraki Y, Ishibashi Y, Hiruma M, Nishikawa A, Ikeda S. Candida albicans abrogates the expression of interferon-gamma-inducible protein-10 in human keratinocytes. FEMS Immunol Med Microbiol. 2008;54:122-8 pubmed publisher
    ..albicans-infected NHEK. Thus, Candida-derived PGE(2) may impair IFN-gamma-induced IP-10 expression in human keratinocytes and may play a role in the pathogenesis of cutaneous candidiasis. ..
  3. Wilson N, Solomon W, ANDERSON L, Patrickson J, Pitts S, Bond V, et al. Pharmacologic inhibition of CXCL10 in combination with anti-malarial therapy eliminates mortality associated with murine model of cerebral malaria. PLoS ONE. 2013;8:e60898 pubmed publisher
    ..Thus, adjunctive therapies are urgently needed to prevent or reduce such mortalities. Overproduction of CXCL10 in a subset of CM patients has been shown to be tightly associated with fatal human CM...
  4. Liu M, Guo S, Hibbert J, Jain V, Singh N, Wilson N, et al. CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications. Cytokine Growth Factor Rev. 2011;22:121-30 pubmed publisher
    C-X-C motif chemokine 10 (CXCL10) also known as interferon ?-induced protein 10 kDa (IP-10) or small-inducible cytokine B10 is a cytokine belonging to the CXC chemokine family...
  5. Deng G, Zhou G, Zhang R, Zhai Y, Zhao W, Yan Z, et al. Regulatory polymorphisms in the promoter of CXCL10 gene and disease progression in male hepatitis B virus carriers. Gastroenterology. 2008;134:716-26 pubmed publisher
    The importance of expression of interferon gamma-inducible protein of 10 kilodaltons (IP-10, CXCL10) during chronic hepatitis B virus (HBV) infection has been recently emphasized...
  6. Klich I, Fendler W, Wyka K, Młynarski W. Effect of the IP10 (CXCL10) and HLA genotype on the risk of type 1 diabetes in children. Pediatr Endocrinol Diabetes Metab. 2011;17:10-3 pubmed
    ..Recent reports suggest involvement of the IP10 (CXCL10) chemokine in autoimmunity towards pancreatic ? cells...
  7. Dhillon N, Zhu X, Peng F, Yao H, Williams R, Qiu J, et al. Molecular mechanism(s) involved in the synergistic induction of CXCL10 by human immunodeficiency virus type 1 Tat and interferon-gamma in macrophages. J Neurovirol. 2008;14:196-204 pubmed publisher
    ..The chemokine CXCL10 has been found to be closely associated with the progression of HIV-1-related central nervous system (CNS) disease ..
  8. Kanda N, Watanabe S. Prolactin enhances interferon-gamma-induced production of CXC ligand 9 (CXCL9), CXCL10, and CXCL11 in human keratinocytes. Endocrinology. 2007;148:2317-25 pubmed
    ..Prolactin may be involved in the pathogenesis of psoriasis. CXC ligand 9 (CXCL9), CXCL10, and CXCL11 recruit type 1 T cells, and their production by keratinocytes is enhanced in psoriatic lesions...
  9. Beinhardt S, Aberle J, Strasser M, Dulic Lakovic E, Maieron A, Kreil A, et al. Serum level of IP-10 increases predictive value of IL28B polymorphisms for spontaneous clearance of acute HCV infection. Gastroenterology. 2012;142:78-85.e2 pubmed publisher
    ..01). The combination of serum level of IP-10 and SNPs in IL28B can identify patients with AHC who are most likely to undergo spontaneous clearance and those in need of early antiviral therapy. ..

More Information

Publications69

  1. Bruck P, Bartsch W, Penna Martinez M, Kahles H, Seidl C, Böhme A, et al. Polymorphisms of CXCR3-binding chemokines in type 1 diabetes. Hum Immunol. 2009;70:552-5 pubmed publisher
    ..300) and family (n = 221) analysis was performed to investigate the role of the CXCL9 (rs10336, rs3733236) and CXCL10 (rs3921, rs35795399 and rs8878) polymorphisms and their interaction with HLA high-risk haplotypes DQ2(DQA*0501-DQB*..
  2. Brightling C, Ammit A, Kaur D, Black J, Wardlaw A, Hughes J, et al. The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle. Am J Respir Crit Care Med. 2005;171:1103-8 pubmed
    ..Most importantly, CXCL10 was expressed preferentially by asthmatic airway smooth muscle in bronchial biopsies and ex vivo cells compared ..
  3. Dong S, Zhang X, He Y, Xu F, Li D, Xu W, et al. Synergy of IL-27 and TNF-? in regulating CXCL10 expression in lung fibroblasts. Am J Respir Cell Mol Biol. 2013;48:518-30 pubmed publisher
    IL-27 is involved in inflammatory reactions. CXCL10 is an important chemokine contributing to airway inflammatory disease...
  4. Hiroi M, Ohmori Y. Constitutive nuclear factor kappaB activity is required to elicit interferon-gamma-induced expression of chemokine CXC ligand 9 (CXCL9) and CXCL10 in human tumour cell lines. Biochem J. 2003;376:393-402 pubmed
    CXC ligand 10 (CXCL10) and CXCL9 are chemoattractants for activated T cells and possess angiostatic activity...
  5. Hanaoka R, Kasama T, Muramatsu M, Yajima N, Shiozawa F, Miwa Y, et al. A novel mechanism for the regulation of IFN-gamma inducible protein-10 expression in rheumatoid arthritis. Arthritis Res Ther. 2003;5:R74-81 pubmed
  6. Wilson N, Jain V, Roberts C, Lucchi N, Joel P, Singh M, et al. CXCL4 and CXCL10 predict risk of fatal cerebral malaria. Dis Markers. 2011;30:39-49 pubmed publisher
    ..Recent studies revealed that elevated levels of CXCL10 expression in cerebrospinal fluid and peripheral blood plasma independently predicted severe and fatal CM...
  7. Kawamura A, Miura S, Fujino M, Nishikawa H, Matsuo Y, Tanigawa H, et al. CXCR3 chemokine receptor-plasma IP10 interaction in patients with coronary artery disease. Circ J. 2003;67:851-4 pubmed
    ..The CXCR3 - plasma IP10 chemokine receptor - chemokine interaction on monocytes may affect the development of coronary restenosis, but not de novo stenosis, in patients with CAD. ..
  8. Gotsch F, Romero R, Friel L, Kusanovic J, Espinoza J, Erez O, et al. CXCL10/IP-10: a missing link between inflammation and anti-angiogenesis in preeclampsia?. J Matern Fetal Neonatal Med. 2007;20:777-92 pubmed
    Interferon (IFN)-gamma inducible protein, CXCL10/IP-10, is a member of the CXC chemokine family with pro-inflammatory and anti-angiogenic properties. This chemokine has been proposed to be a key link between inflammation and angiogenesis...
  9. Reddy P, Aksoy M, Yang Y, Li X, Ji R, Kelsen S. Inhibition by salmeterol and cilomilast of fluticasone-enhanced IP-10 release in airway epithelial cells. COPD. 2008;5:5-11 pubmed publisher
    The CXC chemokines, IP-10/CXCL10 and IL-8/CXCL8, play a role in obstructive lung disease by attracting Th1/Tc1 lymphocytes and neutrophils, respectively. Inhaled corticosteroids (ICS) and long acting beta 2-agonists (LABA) are widely used...
  10. Darling J, Aerssens J, Fanning G, McHutchison J, Goldstein D, Thompson A, et al. Quantitation of pretreatment serum interferon-?-inducible protein-10 improves the predictive value of an IL28B gene polymorphism for hepatitis C treatment response. Hepatology. 2011;53:14-22 pubmed publisher
    ..This relationship warrants further investigation to elucidate the mechanisms of antiviral response and prospective validation. ..
  11. Jiang Z, Xu Y, Cai S. CXCL10 expression and prognostic significance in stage II and III colorectal cancer. Mol Biol Rep. 2010;37:3029-36 pubmed publisher
    CXC Chemokine Ligand 10 (CXCL10), an interferon-inducible protein, has been demonstrated to inhibit the proliferation and metastasis in many tumors...
  12. Mulligan A, Raitman I, Feeley L, Pinnaduwage D, Nguyen L, O Malley F, et al. Tumoral lymphocytic infiltration and expression of the chemokine CXCL10 in breast cancers from the Ontario Familial Breast Cancer Registry. Clin Cancer Res. 2013;19:336-46 pubmed publisher
    ..We explored tumoral expression of CXCL10 and determined the relationship between CXCL10 and lymphocytic infiltrate in a cohort of breast cancers...
  13. Lagging M, Askarieh G, Negro F, Bibert S, Soderholm J, Westin J, et al. Response prediction in chronic hepatitis C by assessment of IP-10 and IL28B-related single nucleotide polymorphisms. PLoS ONE. 2011;6:e17232 pubmed publisher
    ..Concomitant assessment of pretreatment IP-10 and IL28B-related SNPs augments the prediction of the first phase decline in HCV RNA, RVR, and final therapeutic outcome. ..
  14. Singh L, Bakshi D, Majumdar S, Vasishta R, Arora S, Wig J. Expression of interferon-gamma- inducible protein-10 and its receptor CXCR3 in chronic pancreatitis. Pancreatology. 2007;7:479-90 pubmed
    ..Hence, this study was carried out to analyze the expression of CXCL10 and CXCR3 in CP tissues...
  15. Feng J, Zhang Z, Li W, Shen X, Song W, Yang C, et al. Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels. PLoS ONE. 2009;4:e8480 pubmed publisher
  16. Ruhwald M, Petersen J, Kofoed K, Nakaoka H, Cuevas L, Lawson L, et al. Improving T-cell assays for the diagnosis of latent TB infection: potential of a diagnostic test based on IP-10. PLoS ONE. 2008;3:e2858 pubmed publisher
    ..We have demonstrated that IP-10 and possibly IL-2 could be alternative or adjunct markers to IFN-gamma in the diagnosis infection with M.tuberculosis. ..
  17. Chen J, Lu H, Lai S, Campanella G, Sung J, Lu M, et al. Dengue virus induces expression of CXC chemokine ligand 10/IFN-gamma-inducible protein 10, which competitively inhibits viral binding to cell surface heparan sulfate. J Immunol. 2006;177:3185-92 pubmed
    ..We found that CXCL10/IFN-gamma-inducible protein 10 (IP-10) expression was rapidly and transiently induced in liver following infection...
  18. Chen D, Shen G, Chen Y, Chen H, Lin C, Hsieh C, et al. Interferon-inducible protein-10 as a marker to detect latent and active tuberculosis in rheumatoid arthritis. Int J Tuberc Lung Dis. 2011;15:192-200 pubmed
    ..The performance of IP-10 is superior to IFN-? for detecting LTBI (TST+) and active TB. IP-10 may be used for detecting LTBI and as a potential biomarker to identify active TB in RA patients receiving anti-TNF-? treatment. ..
  19. Bodnar R, Yates C, Rodgers M, Du X, Wells A. IP-10 induces dissociation of newly formed blood vessels. J Cell Sci. 2009;122:2064-77 pubmed publisher
    ..Treatment of endothelial cords with CXCL10 (IP-10), a CXCR3 ligand present during the resolving phase of wounds, either in vitro or in vivo caused ..
  20. Tang N, Fan H, Chang K, Ching J, Kong K, Yew W, et al. Genetic association between a chemokine gene CXCL-10 (IP-10, interferon gamma inducible protein 10) and susceptibility to tuberculosis. Clin Chim Acta. 2009;406:98-102 pubmed publisher
    ..This SNP, located at 14bp upstream of a NF-kB binding site, might also account for the susceptibility to TB. Our results expanded the clinical significance of this SNP in CXCL-10 promoter. ..
  21. Williams R, Dhillon N, Hegde S, Yao H, Peng F, Callen S, et al. Proinflammatory cytokines and HIV-1 synergistically enhance CXCL10 expression in human astrocytes. Glia. 2009;57:734-43 pubmed publisher
    ..important reservoir for the generation of inflammatory mediators, including interferon-gamma inducible peptide-10 (CXCL10), a neurotoxin and a chemoattractant, implicated in the pathophysiology of HAD...
  22. Lasagni L, Francalanci M, Annunziato F, Lazzeri E, Giannini S, Cosmi L, et al. An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. J Exp Med. 2003;197:1537-49 pubmed
    The chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC regulate lymphocyte chemotaxis, mediate vascular pericyte proliferation, and act as angiostatic agents, thus inhibiting tumor growth...
  23. Galimberti D, Scalabrini D, Fenoglio C, Comi C, De Riz M, Venturelli E, et al. CXCL10 haplotypes and multiple sclerosis: association and correlation with clinical course. Eur J Neurol. 2007;14:162-7 pubmed
    b>CXCL10 (interferon-gamma-inducible protein-10) levels are increased in cerebrospinal fluid of multiple sclerosis (MS) patients with symptomatic attacks of inflammatory demyelination, supporting a role for this molecule in MS pathogenesis...
  24. Yeruva S, Ramadori G, Raddatz D. NF-kappaB-dependent synergistic regulation of CXCL10 gene expression by IL-1beta and IFN-gamma in human intestinal epithelial cell lines. Int J Colorectal Dis. 2008;23:305-17 pubmed
    Little is known about the intestinal epithelial expression and secretion of CXCL10 (IP-10), a chemokine involved in recruiting T cells and monocytes...
  25. Strzelak A, Komorowska Piotrowska A, Ziołkowski J. [CXCL10/IP-10 as a new biomarker for Mycobacterium tuberculosis infection]. Pol Merkur Lekarski. 2012;33:342-5 pubmed
    ..More studies are still needed to fully assess the benefits of IP-10 level measurement as a biomarker for tuberculous infection, especially in children. ..
  26. Gallo A, Saad A, Ali R, Dardik A, Tellides G, Geirsson A. Circulating interferon-?-inducible Cys-X-Cys chemokine receptor 3 ligands are elevated in humans with aortic aneurysms and Cys-X-Cys chemokine receptor 3 is necessary for aneurysm formation in mice. J Thorac Cardiovasc Surg. 2012;143:704-10 pubmed publisher
    ..The Cys-X-Cys chemokine receptor 3 receptor is necessary for vascular inflammation and the formation of arterial aneurysms in mice. ..
  27. Yang D, Chen Q, Hoover D, Staley P, Tucker K, Lubkowski J, et al. Many chemokines including CCL20/MIP-3alpha display antimicrobial activity. J Leukoc Biol. 2003;74:448-55 pubmed
  28. Cheung C, Poon L, Ng I, Luk W, Sia S, Wu M, et al. Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: possible relevance to pathogenesis. J Virol. 2005;79:7819-26 pubmed
    ..Furthermore, SARS-CoV induced the expression of chemokines such as CXCL10/IFN-gamma-inducible protein 10 and CCL2/monocyte chemotactic protein 1...
  29. Casrouge A, Decalf J, Ahloulay M, Lababidi C, Mansour H, Vallet Pichard A, et al. Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV. J Clin Invest. 2011;121:308-17 pubmed publisher
    ..Recent studies identified the chemokine CXCL10 (also known as IP-10) as an important negative prognostic biomarker...
  30. Reiberger T, Aberle J, Kundi M, Kohrgruber N, Rieger A, Gangl A, et al. IP-10 correlates with hepatitis C viral load, hepatic inflammation and fibrosis and predicts hepatitis C virus relapse or non-response in HIV-HCV coinfection. Antivir Ther. 2008;13:969-76 pubmed
  31. Roe B, Coughlan S, Hassan J, Grogan A, Farrell G, Norris S, et al. Elevated serum levels of interferon- gamma -inducible protein-10 in patients coinfected with hepatitis C virus and HIV. J Infect Dis. 2007;196:1053-7 pubmed
    ..Elevated IP-10 levels are associated with and may contribute to liver damage in both HCV-monoinfected and HCV/HIV-coinfected patients. ..
  32. Lee E, Lee Z, Song Y. CXCL10 and autoimmune diseases. Autoimmun Rev. 2009;8:379-83 pubmed publisher
    b>CXCL10 is a 10 kDa protein, which is categorized functionally as a Th1-chemokine...
  33. Whittaker E, Gordon A, Kampmann B. Is IP-10 a better biomarker for active and latent tuberculosis in children than IFNgamma?. PLoS ONE. 2008;3:e3901 pubmed publisher
    ..IFN-gamma-inducible protein 10 (IP-10/CXCL10) has recently been evaluated as a marker for active TB in adults with promising results...
  34. Sato E, Fujimoto J, Toyoki H, Sakaguchi H, Alam S, Jahan I, et al. Expression of IP-10 related to angiogenesis in uterine cervical cancers. Br J Cancer. 2007;96:1735-9 pubmed
    ..Furthermore, IP-10 activation might be effective on the suppression of regrowth or recurrence after intensive treatment for advanced cervical cancers. ..
  35. Datta D, Flaxenburg J, Laxmanan S, Geehan C, Grimm M, Waaga Gasser A, et al. Ras-induced modulation of CXCL10 and its receptor splice variant CXCR3-B in MDA-MB-435 and MCF-7 cells: relevance for the development of human breast cancer. Cancer Res. 2006;66:9509-18 pubmed
    ..Human breast cancer cells express the chemokine CXCL10 (IP-10) and also its receptor CXCR3...
  36. Ostvik A, Granlund A, Bugge M, Nilsen N, Torp S, Waldum H, et al. Enhanced expression of CXCL10 in inflammatory bowel disease: potential role of mucosal Toll-like receptor 3 stimulation. Inflamm Bowel Dis. 2013;19:265-74 pubmed publisher
    ..The chemokine CXCL10 and its receptor CXCR3 were among the upregulated genes...
  37. Zhou Y, Wang S, Ma J, Lei Z, Zhu H, Lei P, et al. Hepatitis B virus protein X-induced expression of the CXC chemokine IP-10 is mediated through activation of NF-kappaB and increases migration of leukocytes. J Biol Chem. 2010;285:12159-68 pubmed publisher
    ..Our study provides insight into the migration of leukocytes in response to HBV infection, thus causing immune pathological injury of liver. ..
  38. Askarieh G, Alsiö A, Pugnale P, Negro F, Ferrari C, Neumann A, et al. Systemic and intrahepatic interferon-gamma-inducible protein 10 kDa predicts the first-phase decline in hepatitis C virus RNA and overall viral response to therapy in chronic hepatitis C. Hepatology. 2010;51:1523-30 pubmed publisher
    ..006). In contrast, pretreatment levels of IP-10 in liver or in plasma did not affect the decline of HCV RNA between days 8 and 29, i.e., the second-phase decline, or later time points in any of these cohorts...
  39. Cakir M, Levendoglu F, Kiyici A, Coskun Y. Serum CXCL10 levels and neuromuscular manifestations in patients with autoimmune thyroid diseases. Autoimmunity. 2011;44:496-503 pubmed publisher
    Serum C-X-C motif chemokine 10 (CXCL10) levels have been shown to be elevated in autoimmune thyroid diseases (AITD)...
  40. Sato E, Fujimoto J, Tamaya T. Expression of interferon-gamma-inducible protein 10 related to angiogenesis in uterine endometrial cancers. Oncology. 2007;73:246-51 pubmed publisher
    ..Furthermore, IP-10 activation might be effective in the suppression of regrowth or recurrence after intensive treatment for advanced endometrial cancers. ..
  41. Foley J, Yu C, Solow R, Yacobucci M, Peden K, Farber J. Roles for CXC chemokine ligands 10 and 11 in recruiting CD4+ T cells to HIV-1-infected monocyte-derived macrophages, dendritic cells, and lymph nodes. J Immunol. 2005;174:4892-900 pubmed
    ..Of the 12 chemokines analyzed, mRNAs for two, CXCL10 and CXCL11, ligands for the chemokine receptor CXCR3, were up-regulated in both cell types upon infection by HIV-1...
  42. Berenguer J, Fernandez Rodriguez A, Jimenez Sousa M, Cosin J, Zarate P, Micheloud D, et al. High plasma CXCL10 levels are associated with HCV-genotype 1, and higher insulin resistance, fibrosis, and HIV viral load in HIV/HCV coinfected patients. Cytokine. 2012;57:25-9 pubmed publisher
    b>CXCL10 may contribute to the host immune response against the hepatitis C virus (HCV), liver disease progression, and response to HCV antiviral therapy...
  43. Rabquer B, Tsou P, Hou Y, Thirunavukkarasu E, Haines G, Impens A, et al. Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis. Arthritis Res Ther. 2011;13:R18 pubmed publisher
    ..ELR) motif, such as monokine induced by interferon-? (IFN-?) (MIG/CXCL9) and IFN-inducible protein 10 (IP-10/CXCL10), inhibit angiogenesis by binding CXCR3...
  44. Zaheer R, Proud D. Human rhinovirus-induced epithelial production of CXCL10 is dependent upon IFN regulatory factor-1. Am J Respir Cell Mol Biol. 2010;43:413-21 pubmed publisher
    ..HRV-induced production of proinflammatory chemokines, such as CXCL10, from infected airway epithelial cells may play a role in the pathogenesis of exacerbations...
  45. Bodnar R, Yates C, Wells A. IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain. Circ Res. 2006;98:617-25 pubmed
    ..role CXCR3 plays in regulating endothelial function, we analyzed the ability of a CXCR3 ligand, IP-10 (CXCL10), to influence endothelial cell tube formation...
  46. Ruhwald M, Bodmer T, Maier C, Jepsen M, Haaland M, Eugen Olsen J, et al. Evaluating the potential of IP-10 and MCP-2 as biomarkers for the diagnosis of tuberculosis. Eur Respir J. 2008;32:1607-15 pubmed publisher
    ..Combining interferon-gamma inducible protein-10 and interferon-gamma may be a simple approach to increase the detection rate of the Mycobacterium tuberculosis-specific in vitro tests. ..
  47. Lane B, King S, Bock P, Strieter R, Coffey M, Markovitz D. The C-X-C chemokine IP-10 stimulates HIV-1 replication. Virology. 2003;307:122-34 pubmed
    ..Interferon-gamma-inducible protein 10 (IP-10/CXCL10) is a C-X-C chemokine that acts specifically upon activated T cells and macrophages and attracts T cells into the ..
  48. Koten K, Hirohata S, Miyoshi T, Ogawa H, Usui S, Shinohata R, et al. Serum interferon-gamma-inducible protein 10 level was increased in myocardial infarction patients, and negatively correlated with infarct size. Clin Biochem. 2008;41:30-7 pubmed
    ..The serum IP-10 level was increased in AMI, and a higher level of serum IP-10 before PCI may be informative regarding infarct size. ..
  49. Williams R, Yao H, Peng F, Yang Y, Bethel Brown C, Buch S. Cooperative induction of CXCL10 involves NADPH oxidase: Implications for HIV dementia. Glia. 2010;58:611-21 pubmed publisher
    ..b>CXCL10 is a neurotoxic chemokine that is upregulated in astroglia activated by HIV-1 Tat, IFN-gamma, and TNF-alpha...
  50. Laragione T, Brenner M, Sherry B, Gulko P. CXCL10 and its receptor CXCR3 regulate synovial fibroblast invasion in rheumatoid arthritis. Arthritis Rheum. 2011;63:3274-83 pubmed publisher
    b>CXCL10 is expressed in increased levels in highly invasive fibroblast-like synoviocytes (FLS) from arthritic DA rats and from patients with rheumatoid arthritis (RA)...
  51. Wark P, Bucchieri F, Johnston S, Gibson P, Hamilton L, Mimica J, et al. IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations. J Allergy Clin Immunol. 2007;120:586-93 pubmed
    ..8; P < .01). IP-10 release is specific to acute virus-induced asthma. Measurement of serum IP-10 could be used to predict a viral trigger to acute asthma. ..
  52. Campanella G, Lee E, Sun J, Luster A. CXCR3 and heparin binding sites of the chemokine IP-10 (CXCL10). J Biol Chem. 2003;278:17066-74 pubmed
    The chemokine IP-10 (interferon-inducible protein of 10 kDa, CXCL10) binds the G protein-coupled receptor CXCR3, which is found mainly on activated T cells and NK cells, and plays an important role in Th1-type inflammatory diseases...
  53. Van Den Steen P, Husson S, Proost P, Van Damme J, Opdenakker G. Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase. Biochem Biophys Res Commun. 2003;310:889-96 pubmed
    ..Alignment of the CXC chemokines with the respective cleavage sites by both MMPs identified the ELR motif as a possible determinant for amino terminal cleavage by these MMPs. ..
  54. Berg A, Korsgren O, Frisk G. Induction of the chemokine interferon-gamma-inducible protein-10 in human pancreatic islets during enterovirus infection. Diabetologia. 2006;49:2697-703 pubmed
    ..to upregulation of interferon-gamma-inducible protein (IP-10, now known as chemokine [C-X-C motif] ligand 10 [CXCL10]), a chemokine important for the induction of insulitis...
  55. Mihm S, Schweyer S, Ramadori G. Expression of the chemokine IP-10 correlates with the accumulation of hepatic IFN-gamma and IL-18 mRNA in chronic hepatitis C but not in hepatitis B. J Med Virol. 2003;70:562-70 pubmed
    ..g., via its ability to activate IL-18 expressing cells and to initiate a delayed type hypersensitivity reaction. ..
  56. Raju R, Malloy A, Shah T, Smith R, Oaks M, Hosenpud J. Alloimmune induction of endothelial cell-derived interferon-gamma-inducible chemokines. Transplantation. 2003;75:1072-4 pubmed
    ..8+/-17.8 pg/mL). Vascular endothelial cells are capable of producing inflammatory chemokines when activated and potentially serve to amplify the allogeneic response. ..
  57. Lu X, Masic A, Liu Q, Zhou Y. Regulation of influenza A virus induced CXCL-10 gene expression requires PI3K/Akt pathway and IRF3 transcription factor. Mol Immunol. 2011;48:1417-23 pubmed publisher
    ..Our data suggested that PI3K/AKT pathway contributes to influenza A virus induced CXCL-10 production. This process is involved in binding of IRF3 to the ISRE binding site in CXCL-10 promoter region. ..
  58. Lee E, Lee Z, Song Y. The interaction between CXCL10 and cytokines in chronic inflammatory arthritis. Autoimmun Rev. 2013;12:554-7 pubmed publisher
    ..Of those, CXCL10 and its receptor, CXCR3, are increased in many kinds of chronic inflammatory arthritis, especially in rheumatoid ..
  59. van Marle G, Henry S, Todoruk T, Sullivan A, Silva C, Rourke S, et al. Human immunodeficiency virus type 1 Nef protein mediates neural cell death: a neurotoxic role for IP-10. Virology. 2004;329:302-18 pubmed
    ..Furthermore, Nef molecular diversity was evident in brain tissue among patients with neurological disease and which may influence IP-10 production by astrocytes. ..
  60. Campanella G, Colvin R, Luster A. CXCL10 can inhibit endothelial cell proliferation independently of CXCR3. PLoS ONE. 2010;5:e12700 pubmed publisher
    b>CXCL10 (or Interferon-inducible protein of 10 kDa, IP-10) is an interferon-inducible chemokine with potent chemotactic activity on activated effector T cells and other leukocytes expressing its high affinity G protein-coupled receptor ..