CXCL1

Summary

Gene Symbol: CXCL1
Description: C-X-C motif chemokine ligand 1
Alias: FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1, growth-regulated alpha protein, C-X-C motif chemokine 1, GRO-alpha(1-73), GRO1 oncogene (melanoma growth stimulating activity, alpha), GRO1 oncogene (melanoma growth-stimulating activity), MGSA alpha, chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha), fibroblast secretory protein, melanoma growth stimulating activity, alpha, melanoma growth stimulatory activity alpha, neutrophil-activating protein 3
Species: human
Products:     CXCL1

Top Publications

  1. Bachmeier B, Mohrenz I, Mirisola V, Schleicher E, Romeo F, Höhneke C, et al. Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB. Carcinogenesis. 2008;29:779-89 pubmed
    ..Among the 62 genes whose expression was significantly altered, we found the two inflammatory cytokines CXCL1 and -2 (Groalpha and -beta) that were downregulated...
  2. Wang B, Khachigian L, Esau L, Birrer M, Zhao X, Parker M, et al. A key role for early growth response-1 and nuclear factor-kappaB in mediating and maintaining GRO/CXCR2 proliferative signaling in esophageal cancer. Mol Cancer Res. 2009;7:755-64 pubmed publisher
    ..These results indicate that EGR-1 and nuclear factor-kappaB mediate GRO/CXCR2 proliferative signaling in esophageal cancer and may represent potential target molecules for therapeutic intervention. ..
  3. Anisowicz A, Messineo M, Lee S, Sager R. An NF-kappa B-like transcription factor mediates IL-1/TNF-alpha induction of gro in human fibroblasts. J Immunol. 1991;147:520-7 pubmed
  4. Haskill S, Peace A, Morris J, Sporn S, Anisowicz A, Lee S, et al. Identification of three related human GRO genes encoding cytokine functions. Proc Natl Acad Sci U S A. 1990;87:7732-6 pubmed
    ..product of the human GRO gene is a cytokine with inflammatory and growth-regulatory properties; GRO is also called MGSA for melanoma growth-stimulatory activity...
  5. Anisowicz A, Bardwell L, Sager R. Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells. Proc Natl Acad Sci U S A. 1987;84:7188-92 pubmed
    ..Studies of its transcriptional regulation have shown that expression is tightly regulated by growth status in normal Chinese hamster and human cells and relaxed in the tumorigenic cells so far examined...
  6. Lane B, Liu J, Bock P, Schols D, Coffey M, Strieter R, et al. Interleukin-8 and growth-regulated oncogene alpha mediate angiogenesis in Kaposi's sarcoma. J Virol. 2002;76:11570-83 pubmed
    ..Thus, the three known etiological factors in Kaposi's sarcoma pathogenesis-KSHV, HIV-1 Tat, and cellular growth factors-might be linked, in part, through induction of IL-8 and GRO-alpha. ..
  7. Tamura Y, Sakasegawa Y, Omi K, Kishida H, Asada T, Kimura H, et al. Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population. Neurosci Lett. 2005;379:149-51 pubmed
    ..Chemokine, CXC motif, ligand 1 (CXCL1; or GRO1) is an inflammatory cytokine and appears to be implicated in the pathogenesis of AD...
  8. Fimmel S, Devermann L, Herrmann A, Zouboulis C. GRO-alpha: a potential marker for cancer and aging silenced by RNA interference. Ann N Y Acad Sci. 2007;1119:176-89 pubmed
    ..Thus, GRO-alpha may be a novel diagnostic marker for age-related pathology, including cancer. ..
  9. Kawanishi H, Matsui Y, Ito M, Watanabe J, Takahashi T, Nishizawa K, et al. Secreted CXCL1 is a potential mediator and marker of the tumor invasion of bladder cancer. Clin Cancer Res. 2008;14:2579-87 pubmed publisher
    ..The proteins isolated from cell culture supernatants were identified by shotgun proteomics. We found that CXCL1 is related to the tumor invasion of bladder cancer cells...

More Information

Publications127 found, 100 shown here

  1. Cheng W, Wang C, Huang Y, Tsai M, Liang Y, Lin K. Overexpression of CXCL1 and its receptor CXCR2 promote tumor invasion in gastric cancer. Ann Oncol. 2011;22:2267-76 pubmed publisher
    The chemokine (C-X-C motif) ligand 1 (CXCL1) and its receptor CXCR2 are associated with metastasis potential...
  2. Wang Q, Li D, Zhang W, Tang B, Li Q, Li L. Evaluation of proteomics-identified CCL18 and CXCL1 as circulating tumor markers for differential diagnosis between ovarian carcinomas and benign pelvic masses. Int J Biol Markers. 2011;26:262-73 pubmed publisher
    ..Six differentially expressed proteins (APP, CA 125, CCL18, CXCL1, IL-8, and ITIH4) were separated by high-performance liquid chromatography and identified by matrix-assisted laser ..
  3. Nischalke H, Berger C, Luda C, Müller T, Berg T, Coenen M, et al. The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients. J Hepatol. 2012;56:758-64 pubmed publisher
    b>CXCL1 is a ligand for CXC chemokine-receptor 2 expressed on hepatic stellate cells (HSC). Thus, CXCL1 might contribute to HSC activation and fibrogenesis...
  4. Acharyya S, Oskarsson T, Vanharanta S, Malladi S, Kim J, Morris P, et al. A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell. 2012;150:165-78 pubmed publisher
    ..Cancer cells that overexpress CXCL1 and 2 by transcriptional hyperactivation or 4q21 amplification are primed for survival in metastatic sites...
  5. Yoo J, Jung H, Kim C, Son W, Kim J. miR-7641 modulates the expression of CXCL1 during endothelial differentiation derived from human embryonic stem cells. Arch Pharm Res. 2013;36:353-8 pubmed publisher
    ..The CXCL1, a member of the CXC chemokine family, is known as promoting neovascularization by binding G-protein coupled ..
  6. Nicholls D, Wiley K, Dainty I, MacIntosh F, Phillips C, Gaw A, et al. Pharmacological characterization of AZD5069, a slowly reversible CXC chemokine receptor 2 antagonist. J Pharmacol Exp Ther. 2015;353:340-50 pubmed publisher
    ..In neutrophils, chemokines chemokine (CXC motif) ligand 1 (CXCL1) and CXCL8 are potent chemoattractants and activate G protein-coupled receptors CXC chemokine receptor 1 (CXCR1) ..
  7. Edukulla R, Rehn K, Liu B, McAlees J, Hershey G, Wang Y, et al. Intratracheal myriocin enhances allergen-induced Th2 inflammation and airway hyper-responsiveness. Immun Inflamm Dis. 2016;4:248-62 pubmed publisher
    ..b>CXCL1 was elevated in the BAL fluid of myriocin-treated mice while the neutrophilic chemotactic factors anaphylatoxin ..
  8. Wang L, Yao Y, He R, Meng Y, Li N, Zhang D, et al. Methane ameliorates spinal cord ischemia-reperfusion injury in rats: Antioxidant, anti-inflammatory and anti-apoptotic activity mediated by Nrf2 activation. Free Radic Biol Med. 2017;103:69-86 pubmed publisher
    ..Thus, methane may serve as a novel promising therapeutic agent for treating ischemic spinal cord injury. ..
  9. Colavite P, Vieira A, Palanch Repeke C, de Araujo Linhari R, De Andrade R, Borrego A, et al. Alveolar bone healing in mice genetically selected in the maximum (AIRmax) or minimum (AIRmin) inflammatory reaction. Cytokine. 2019;114:47-60 pubmed publisher
    ..GR1+ cells counts in AIRmax strain at 3d, associated with increased levels of neutrophil chemoattractants such as CXCL1 and CXCL2, and its receptor CXCR1, while F4/80+ cell prevails in AIRmin strain at 7d...
  10. Wang Z, Li R, Zhong R. Extracellular matrix promotes proliferation, migration and adhesion of airway smooth muscle cells in a rat model of chronic obstructive pulmonary disease via upregulation of the PI3K/AKT signaling pathway. Mol Med Rep. 2018;18:3143-3152 pubmed publisher
    ..as demonstrated by ELISA, treatment with ECM components increased levels of C‑X‑C motif chemokine ligand 1 (CXCL1), CXCL8 and interleukin‑6 in ASMCs...
  11. Singhania A, Wallington J, Smith C, Horowitz D, Staples K, Howarth P, et al. Multi-tissue Transcriptomics Delineates the Diversity of Airway T Cell Functions in Asthma. Am J Respir Cell Mol Biol. 2017;: pubmed publisher
    ..This signature included IL-17-inducible chemokines (CXCL1, CXCL2, CXCL3, IL8, CSF3) and chemoattractants for neutrophils (IL8, CCL3, LGALS3), T cells and monocytes...
  12. Martorell S, Hueso L, Gonzalez Navarro H, Collado A, Sanz M, Piqueras L. Vitamin D Receptor Activation Reduces Angiotensin-II-Induced Dissecting Abdominal Aortic Aneurysm in Apolipoprotein E-Knockout Mice. Arterioscler Thromb Vasc Biol. 2016;36:1587-97 pubmed publisher
    ..and matrix metalloproteinase-9, chemokine (CCL2 [(C-C motif) ligand 2], CCL5 [(C-C motif) ligand 5], and CXCL1 [(C-X-C motif) ligand 1]) and vascular endothelial growth factor expression in suprarenal aortic walls of apoE(-/-)..
  13. Chiu C, Wen L, Pao H, Yang L, Huang Y, Wang J. Reparixin attenuates neuronal injury in experimental Klebsiella pneumoniae meningoencephalitis through dual effects on neuroprotection and neuroinflammation. Neuropathol Appl Neurobiol. 2016;42:326-43 pubmed publisher
    ..Reparixin reduced the elevated CSF concentrations of chemokines [CXCL1, CXCL2, chemokine (C-C motif) ligand (CCL)2 and CCL5] and proinflammatory cytokines...
  14. Bao S, Zhao Q, Zheng J, Li N, Huang C, Chen M, et al. Interleukin-23 mediates the pathogenesis of LPS/GalN-induced liver injury in mice. Int Immunopharmacol. 2017;46:97-104 pubmed publisher
    ..and the expression of Th17-related cytokines, including IL-17 and TNF-?; neutrophil chemoattractants, including Cxcl1, Cxcl2, Cxcl9, and Cxcl10; and the stabilization factor Csf3 were assessed in liver tissue...
  15. Peng C, Huang K, Lan C, Hsu Y, Wu G, Peng C, et al. Experimental chronic kidney disease attenuates ischemia-reperfusion injury in an ex vivo rat lung model. PLoS ONE. 2017;12:e0171736 pubmed publisher
    ..including pulmonary edema, lipid peroxidation, histopathological changes, immunohistochemistry changes, chemokine CXCL1, inducible nitric oxide synthase (iNOS), proinflammatory and anti-inflammatory cytokines, heat shock protein ..
  16. Shen Z, Mannion A, Whary M, Muthupalani S, Sheh A, Feng Y, et al. Helicobacter saguini, a Novel Helicobacter Isolated from Cotton-Top Tamarins with Ulcerative Colitis, Has Proinflammatory Properties and Induces Typhlocolitis and Dysplasia in Gnotobiotic IL-10-/- Mice. Infect Immun. 2016;84:2307-2316 pubmed publisher
    ..the proinflammatory cytokines IL-1β, tumor necrosis factor alpha (TNF-α), IL-10, and IL-6 and the chemokine CXCL1 were upregulated in cocultured HT-29 cells at 4 h compared to levels in control cells...
  17. Engen S, Schreurs O, Petersen F, Blix I, Baekkevold E, Schenck K. The regulatory role of the oral commensal Streptococcus mitis on human monocytes. Scand J Immunol. 2017;: pubmed publisher
    ..mitis (SmMo) revealed increased transcription of chemotactic factors (CCL2, CCL3, CCL20, CXCL1, CXCL2) and cytokines (IL1A, IL1B, IL6, IL23, IL36G, TNF), indicating that S...
  18. Chen S, Yin R, Mutze K, Yu Y, Takenaka S, Konigshoff M, et al. No involvement of alveolar macrophages in the initiation of carbon nanoparticle induced acute lung inflammation in mice. Part Fibre Toxicol. 2016;13:33 pubmed publisher
    ..BAL concentrations and lung gene expression profiles of TNF?, and the neutrophil chemoattractants CXCL1,-2 and-5 preceded the neutrophil recruitment and showed highest levels after 12 h of CNP exposure, pointing to a ..
  19. Willson T, Kuhn B, Jurickova I, Gerad S, Moon D, Bonkowski E, et al. STAT3 genotypic variation and cellular STAT3 activation and colon leukocyte recruitment in pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2012;55:32-43 pubmed publisher
    ..Colonic expression of interleukin 6 (IL-6), the STAT3 target gene SOCS3, the neutrophil chemoattractants IL-8, CXCL1, and CXCL3, and the neutrophil products S100A8, S100A9, and S100A12 were increased in patients carrying the STAT3 "..
  20. Li X, Gu X, Boyce T, Zheng M, Reagan A, Qi H, et al. Caveolin-1 increases proinflammatory chemoattractants and blood-retinal barrier breakdown but decreases leukocyte recruitment in inflammation. Invest Ophthalmol Vis Sci. 2014;55:6224-34 pubmed publisher
    ..resulted in significant blunting of proinflammatory cytokine (monocyte chemoattractant protein-1 [MCP-1/CCL2], CXCL1/KC, IL-6, and IL-1β) responses as well as reduced inflammatory BRB breakdown in Cav-1 KO retinas...
  21. Stofkova A, Krskova K, Vaculin S, Jurcovicova J. Enhanced activity of hormone sensitive lipase (HSL) in mesenteric but not epididymal fat correlates with higher production of epinephrine in mesenteric adipocytes in rat model of cachectic rheumatoid arthritis. Autoimmunity. 2016;49:268-76 pubmed publisher
    ..Cytokine-induced neutrophil chemoattractant-1 (CINC-1/CXCL1), monocyte chemoattractant protein-1 (MCP-1/CCL2), IL-1?, IL-6, IL-10 and leptin in adipocyte lysate were analyzed ..
  22. Saeed W, Jun D, Jang K, Ahn S, Oh J, Chae Y, et al. Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in non-alcoholic fatty liver disease. World J Gastroenterol. 2018;24:5477-5490 pubmed publisher
    ..Inflammatory signals (CXCL1/2, TNF-α, and interleukin-6) increased after lipopolysaccharide and pan-caspase inhibitor (necroptotic condition) ..
  23. Mizugishi K, Inoue T, Hatayama H, Bielawski J, Pierce J, Sato Y, et al. Sphingolipid pathway regulates innate immune responses at the fetomaternal interface during pregnancy. J Biol Chem. 2015;290:2053-68 pubmed publisher
    ..sphingosine kinase gene (Sphk) during pregnancy caused unusually high expression of neutrophil chemoattractants, CXCL1 and CXCL2, in the decidua, leading to a massive infiltration of neutrophils into the fetomaternal interface with ..
  24. Singh K, Al Greene N, Verriere T, Coburn L, Asim M, Barry D, et al. The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria. PLoS Pathog. 2016;12:e1005984 pubmed publisher
    ..there were decreased levels of the proinflammatory cytokines G-CSF, TNF-?, IL-1?, IL-1?, and the chemokines CXCL1, CCL2, CCL3, CCL4, CXCL2, and CCL5...
  25. Xu M, Cai Y, Wang H, Altamirano J, Chang B, Bertola A, et al. Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans. Gastroenterology. 2015;149:1030-41.e6 pubmed publisher
    ..tissues to identify molecules associated with ASH progression and focused on the mouse fat-specific protein 27 (FSP-27)/human cell death-inducing DFF45-like effector C (CIDEC) protein, which is expressed in white adipose tissues ..
  26. Wagner R, Johnson S, Danielsen Z, Lim J, Mudalige T, Linder S. Polyethylene glycol-functionalized poly (Lactic Acid-co-Glycolic Acid) and graphene oxide nanoparticles induce pro-inflammatory and apoptotic responses in Candida albicans-infected vaginal epithelial cells. PLoS ONE. 2017;12:e0175250 pubmed publisher
    ..They caused the cells to excrete inflammatory recruitment molecules chemokine (C-X-C motif) ligand 1 (CXCL1), interleukin-1α (IL1A), interleukin-1β (IL1B), calprotectin (S100A8), and tumor necrosis factor α (TNF)...
  27. Kim K, Clark Lewis I, Sykes B. Solution structure of GRO/melanoma growth stimulatory activity determined by 1H NMR spectroscopy. J Biol Chem. 1994;269:32909-15 pubmed
    ..three-dimensional solution structure of the growth-related protein-alpha/melanoma growth stimulatory activity (GRO/MGSA) has been solved by two-dimensional 1H nuclear magnetic resonance spectroscopy...
  28. Takamura M, Osuga Y, Izumi G, Yoshino O, Koga K, Saito A, et al. Interleukin-17A is present in neutrophils in endometrioma and stimulates the secretion of growth-regulated oncogene-? (Gro-?) from endometrioma stromal cells. Fertil Steril. 2012;98:1218-24.e1-2 pubmed publisher
    ..It is suggested that IL-17A produced by neutrophils stimulates Gro-? secretion from EoSCs, thereby recruiting more neutrophils and inducing perpetuating inflammation in endometriosis. ..
  29. Lan C, Peng C, Huang S, Huang K, Wu C. Activated protein C attenuates ischemia-reperfusion-induced acute lung injury. Exp Lung Res. 2015;41:241-50 pubmed publisher
    ..This protective effect is possibly associated with the inhibition of TNF-α, IL-17A, CXCL1, and neutrophils infiltration in lung tissues...
  30. Chen Y, Chen H, Deng L, Gui X, Yu L, Xiong Z, et al. [Protective effect of pretreatment with TLR2 agonist Pam3Csk4 on mice challenged by methicillin-resistant Staphylococcus aureus]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016;32:212-6 pubmed
    ..Finally, 24 hours after being pretreated with Pam3Csk4, mRNA levels of CXC chemokine ligand 1 (CXCL1) and Fcγ receptor III (FcγRIII) in spleen of the mice were evaluated by qPCR...
  31. Chen S, Constantinides C, Kebschull M, Papapanou P. MicroRNAs Regulate Cytokine Responses in Gingival Epithelial Cells. Infect Immun. 2016;84:3282-3289 pubmed
    ..miR-126 KD cells showed lower expression of interleukin 8 (IL-8) and CXCL1, both on the mRNA and protein levels, than did controls upon stimulation by heat-killed wild-type Porphyromonas ..
  32. Ujino M, Sugimoto N, Koizumi Y, Ro S, Kojima Y, Asae K, et al. Leukotriene receptor antagonist attenuated airway inflammation and hyperresponsiveness in a double-stranded RNA-induced asthma exacerbation model. Allergol Int. 2017;66S:S21-S26 pubmed publisher
    ..to OVA-sensitized and -challenged mice increased the number of eosinophils and levels of IL-13, IL-9, CCL3, and CXCL1 in BAL fluid (BALF) and tended to increase airway responsiveness...
  33. Donson A, Apps J, Griesinger A, Amani V, Witt D, Anderson R, et al. Molecular Analyses Reveal Inflammatory Mediators in the Solid Component and Cyst Fluid of Human Adamantinomatous Craniopharyngioma. J Neuropathol Exp Neurol. 2017;76:779-788 pubmed publisher
    ..Cytokines and chemokines with particularly elevated concentrations in ACPs were IL-6, CXCL1 (GRO), CXCL8 (IL-8) and the immunosuppressive cytokine IL-10...
  34. Szamatowicz J, Laudanski P, Tomaszewska I, Szamatowicz M. Chemokine growth-regulated-alpha: a possible role in the pathogenesis of endometriosis. Gynecol Endocrinol. 2002;16:137-41 pubmed
    ..It is also feasible that the angiogenic properties of GRO-alpha might prompt the progression of endometriotic lesions. ..
  35. Sawant K, Xu R, Cox R, Hawkins H, Sbrana E, Kolli D, et al. Chemokine CXCL1-Mediated Neutrophil Trafficking in the Lung: Role of CXCR2 Activation. J Innate Immun. 2015;7:647-58 pubmed publisher
    The chemokine CXCL1 and its receptor CXCR2 play a crucial role in host immune response by recruiting and activating neutrophils for microbial killing at the tissue site...
  36. Brempelis K, Yuen S, Schwarz N, Mohar I, Crispe I. Central role of the TIR-domain-containing adaptor-inducing interferon-β (TRIF) adaptor protein in murine sterile liver injury. Hepatology. 2017;65:1336-1351 pubmed publisher
    ..ligand (CCL) 2 and C-X-C motif chemokine ligand (CXCL) 1 chemokines and up-regulation of chemokine (Ccl2, Ccl7, Cxcl1, Cxcl2, and Cxcl10) and cell-adhesion (intracellular adhesion molecule 1 and vascular cell adhesion molecule 1) ..
  37. Zhang C, Wang S, Li J, Zhang W, Zheng L, Yang C, et al. The mTOR signal regulates myeloid-derived suppressor cells differentiation and immunosuppressive function in acute kidney injury. Cell Death Dis. 2017;8:e2695 pubmed publisher
    ..G-MDSCs were recruited to the injured kidney following the interaction of CXCL1, CXCL2 and their receptor CXCR2 after inhibiting mTOR signal with rapamycin treatment...
  38. Wong D, Yiu W, Chan K, Li Y, Li B, Lok S, et al. Activated renal tubular Wnt/β-catenin signaling triggers renal inflammation during overload proteinuria. Kidney Int. 2018;93:1367-1383 pubmed publisher
    ..of M1 macrophage infiltration in the tubulointerstitium and renal cortical up-regulation of CCL-2, IL-17A, IL-1β, CXCL1, and ICAM-1...
  39. Cao J, Ren G, Gong Y, Dong S, Yin Y, Zhang L. Bronchial epithelial cells release IL-6, CXCL1 and CXCL8 upon mast cell interaction. Cytokine. 2011;56:823-31 pubmed publisher
    ..Cytokine IL-6, and chemokines including CXCL1 and CXCL8 in cell culture supernatant were assayed by enzyme-linked immunosorbent assay (ELISA), and the activity ..
  40. Lee S, Kim S, Kook M, Lee H, Ghim J, Choi Y, et al. Phospholipase D2 drives mortality in sepsis by inhibiting neutrophil extracellular trap formation and down-regulating CXCR2. J Exp Med. 2015;212:1381-90 pubmed publisher
    ..Production of several inflammatory cytokines (TNF, IL-1β, IL-17, and IL-23) and the chemokine CXCL1, as well as cellular apoptosis in immune tissues, kidney, and liver, are markedly decreased in PLD2(-/-) mice...
  41. Segal L, Clemente J, Wu B, Wikoff W, Gao Z, Li Y, et al. Randomised, double-blind, placebo-controlled trial with azithromycin selects for anti-inflammatory microbial metabolites in the emphysematous lung. Thorax. 2017;72:13-22 pubmed publisher
    ..Compared with placebo, AZM treatment led to reduced in-vivo levels of chemokine (C-X-C) ligand 1 (CXCL1), tumour necrosis factor (TNF)-α, interleukin (IL)-13 and IL-12p40 in BAL, but increased bacterial metabolites ..
  42. Horuk R, Martin A, Wang Z, Schweitzer L, Gerassimides A, Guo H, et al. Expression of chemokine receptors by subsets of neurons in the central nervous system. J Immunol. 1997;158:2882-90 pubmed
    ..These data suggest that chemokines may play a role in reactive processes in normal neuronal function and neurodegenerative disorders. ..
  43. Olivotto E, Vitellozzi R, Fernandez P, Falcieri E, Battistelli M, Burattini S, et al. Chondrocyte hypertrophy and apoptosis induced by GROalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin B. J Cell Physiol. 2007;210:417-27 pubmed
  44. Lin C, Kang K, Lin T, Wu M, Liou H, Chuang W, et al. Role of spinal CXCL1 (GROα) in opioid tolerance: a human-to-rodent translational study. Anesthesiology. 2015;122:666-76 pubmed publisher
    ..The cerebrospinal fluid levels of tumor necrosis factor-alpha, CXCL1, CXCL10, CCL2, and CX3CL1 were assayed...
  45. Wang L, Hu F, Wang Z, Liang J, Li J, Mao G, et al. [Comparative field study on high flow rate samplers for respirable fraction-A solution to smaller collected masses]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2016;34:32-6 pubmed publisher
    ..In A and B two shipyards respirable welding fume was sampled by high flow rate cyclone samplers of FSP-10 (10 L/min) for 2-2...
  46. Giandolini M, Horvais N, Rossi J, Millet G, Samozino P, Morin J. Foot strike pattern differently affects the axial and transverse components of shock acceleration and attenuation in downhill trail running. J Biomech. 2016;49:1765-1771 pubmed publisher
    ..The type of foot strike pattern (FSP) is known to influence impact severity and lower-limb kinematics...
  47. Parkunan S, Randall C, Astley R, Furtado G, Lira S, Callegan M. CXCL1, but not IL-6, significantly impacts intraocular inflammation during infection. J Leukoc Biol. 2016;100:1125-1134 pubmed
    ..We hypothesized that cytokine IL-6 and chemokine CXCL1 contributed to rapid neutrophil recruitment during Bacillus cereus endophthalmitis, a severe form of intraocular ..
  48. Mitsui H, Kiecker F, Shemer A, Cannizzaro M, Wang C, Gulati N, et al. Discrimination of Dysplastic Nevi from Common Melanocytic Nevi by Cellular and Molecular Criteria. J Invest Dermatol. 2016;136:2030-2040 pubmed publisher
    ..of T helper type 1 (IFN?) and T helper type 2 (IL13) cytokines as well as an upregulation of oncostatin M and CXCL1. DUSP3, which regulates cellular senescence, was identified as one of the disease discriminative genes between DNs ..
  49. Santuz A, Ekizos A, Arampatzis A. A Pressure Plate-Based Method for the Automatic Assessment of Foot Strike Patterns During Running. Ann Biomed Eng. 2016;44:1646-55 pubmed publisher
    The foot strike pattern (FSP, description of how the foot touches the ground at impact) is recognized to be a predictor of both performance and injury risk...
  50. Dave M, Silva J, Eliçabe R, Jeréz M, Filippa V, Gorlino C, et al. Yersinia enterocolitica YopH-Deficient Strain Activates Neutrophil Recruitment to Peyer's Patches and Promotes Clearance of the Virulent Strain. Infect Immun. 2016;84:3172-3181 pubmed publisher
    ..While the Y. enterocolitica wild-type (WT) strain in PP induced the major neutrophil chemoattractant CXCL1 mRNA and protein levels, infection with the Y...
  51. Patrick A, Grin P, Kraus N, Gold M, Berardocco M, Liaw P, et al. Resuscitation fluid composition affects hepatic inflammation in a murine model of early sepsis. Intensive Care Med Exp. 2017;5:5 pubmed publisher
    ..control fluids for all other cytokines, whereas mice given Seplyte L had significantly elevated IL-6, IL-10, KC (CXCL1), and MCP-1 (CCL2)...
  52. Ellman D, Isaksen T, Lund M, Dursun S, Wirenfeldt M, Jørgensen L, et al. The loss-of-function disease-mutation G301R in the Na+/K+-ATPase α2 isoform decreases lesion volume and improves functional outcome after acute spinal cord injury in mice. BMC Neurosci. 2017;18:66 pubmed publisher
    ..no differences in astroglial aquaporin 4 levels and no changes in the expression of chemokines (CCL2, CCL5 and CXCL1) and cytokines (TNF, IL-6, IL-1β, IL-10 and IL-5) between genotypes, just as no apparent differences were ..
  53. Wang H, Li Z, Jiang W, Liao B, Zhai G, Wang N, et al. The activation and function of IL-36γ in neutrophilic inflammation in chronic rhinosinusitis. J Allergy Clin Immunol. 2018;141:1646-1658 pubmed publisher
    ..The proinflammatory effect of IL-36γ was not suppressed by dexamethasone. Increased production and activation of IL-36γ may act on neutrophils and further exaggerate neutrophilic inflammation in CRS. ..
  54. Tran C, Garcia M, Garnier M, Burucoa C, Bodet C. Inflammatory signaling pathways induced by Helicobacter pylori in primary human gastric epithelial cells. Innate Immun. 2017;23:165-174 pubmed publisher
    ..pylori-induced CXCL1, CXCL5 and CXCL8 response in a cag pathogenicity island-independent manner.
  55. Lappas M. RKIP is decreased in laboring myometrium and modulates inflammation-induced pro-labor mediators. Reproduction. 2017;153:545-553 pubmed publisher
    ..The effect of siRKIP in primary myometrial cells was a significant augmentation of IL1B- and TNF-induced CXCL1 and CXCL8 mRNA abundance and secretion; PTGS2 mRNA levels and prostaglandin PGF2α ..
  56. Spaks A, Jaunalksne I, Spaka I, Chudasama D, Pirtnieks A, Krievins D. Diagnostic Value of Circulating CXC Chemokines in Non-small Cell Lung Cancer. Anticancer Res. 2015;35:6979-83 pubmed
    ..The levels of circulating CXCL4, CXCL8, CXCL9, CXCL10 and CXCL11 were higher and those of circulating CXCL1 were lower in patients with early-stage NSCLC compared to metastatic NSCLC patients and controls (p<0.05)...
  57. Victoria E, de Brito Toscano E, de Sousa Cardoso A, da Silva D, de Miranda A, da Silva Barcelos L, et al. Knockdown of C-C Chemokine Receptor 5 (CCR5) is Protective Against Cerebral Ischemia and Reperfusion Injury. Curr Neurovasc Res. 2017;14:125-131 pubmed publisher
    ..outcome, brain damage and expression of pro-inflammatory chemokines: chemokine (C-X-C motif) ligand 1 (CXCL1), chemokine (CC motif) ligand 3 (CCL3) and chemokine (C-C motif) ligand 5 (CCL5), and the brain-derived ..
  58. Rani R, Tandon A, Wang J, Kumar S, Gandhi C. Stellate Cells Orchestrate Concanavalin A-Induced Acute Liver Damage. Am J Pathol. 2017;187:2008-2019 pubmed publisher
    ..ConA-treated HSCs showed increased expression of interferon-β, tumor necrosis factor-α, and CXCL1, induced oxidative stress in hepatocytes, and caused hepatocyte apoptosis...
  59. Jonsson D, Amisten S, Bratthall G, Holm A, Nilsson B. LPS induces GROalpha chemokine production via NF-kappaB in oral fibroblasts. Inflamm Res. 2009;58:791-6 pubmed publisher
    ..The novel chemokine GROalpha, also named CXCL1, is a strong chemoattractant for neutrophils...
  60. Junnila S, Kokkola A, Mizuguchi T, Hirata K, Karjalainen Lindsberg M, Puolakkainen P, et al. Gene expression analysis identifies over-expression of CXCL1, SPARC, SPP1, and SULF1 in gastric cancer. Genes Chromosomes Cancer. 2010;49:28-39 pubmed publisher
    ..The expression levels of four of the up-regulated genes, CXCL1, SPARC, SPP1 and SULF, were further analyzed in 82 gastric tissues using quantitative real-time RT-PCR...
  61. Niazi M, Dhulekar N, Schmidt D, Major S, Cooper R, Abeijon C, et al. Lung necrosis and neutrophils reflect common pathways of susceptibility to Mycobacterium tuberculosis in genetically diverse, immune-competent mice. Dis Model Mech. 2015;8:1141-53 pubmed publisher
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    ..to control samples, greater fold-increases of gene expression were observed for a number of chemotactic factors (CXCL1, CXCL3, IL8, MCP1, MIP1?). ATBD was also associated with higher IL1B gene expression, relative to controls...
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