CUL9

Summary

Gene Symbol: CUL9
Description: cullin 9
Alias: H7AP1, PARC, cullin-9, CUL-9, UbcH7-associated protein 1, p53-associated parkin-like cytoplasmic protein, parkin-like cytoplasmic p53 binding protein
Species: human
Products:     CUL9

Top Publications

  1. Parry Hanson Kunadu A, Holmes M, Miller E, Grant A. Microbiological quality and antimicrobial resistance characterization of Salmonella spp. in fresh milk value chains in Ghana. Int J Food Microbiol. 2018;277:41-49 pubmed publisher
    ..in the following genes: golS, sdiA for cephalosporins, aac(6')-Iy, ant(9) for aminoglycosides, mdtK, gyrA, gyrB, parC, parE for quinolones and cat1, cat4 for phenicols. Phylogenetic analysis based on accessory genes clustered S...
  2. Misra R, Thakare R, Amrin N, Prasad K, Chopra S, Dhole T. Antimicrobial susceptibility pattern and sequence analysis of DNA gyrase and DNA topoisomerase IV in Salmonella enterica serovars Typhi and Paratyphi A isolates with decreased susceptibility to ciprofloxacin. Trans R Soc Trop Med Hyg. 2016;110:472-9 pubmed publisher
    ..characterization included the screening of mutations in the quinolone resistance-determining region of gyrA, gyrB, parC, and parE by PCR. DNA sequence analysis was done for 55 isolates. Out of 100 isolates recovered 80 were S...
  3. Yassin A, Langenberg S, Huntemann M, Clum A, Pillay M, Palaniappan K, et al. Draft genome sequence of Actinotignum schaalii DSM 15541T: Genetic insights into the lifestyle, cell fitness and virulence. PLoS ONE. 2017;12:e0188914 pubmed publisher
    ..ciprofloxacin occurs by mutation in chromosomal genes that encode the subunits of DNA-gyrase (GyrA) and topisomerase IV (ParC) enzymes, while resistant to metronidazole was due to the frxA gene, which encodes NADPH-flavin oxidoreductase.
  4. Su Y, Yu C, Tsai Y, Wang S, Lee C, Chu C. Fluoroquinolone-resistant and extended-spectrum β-lactamase-producing Escherichia coli from the milk of cows with clinical mastitis in Southern Taiwan. J Microbiol Immunol Infect. 2016;49:892-901 pubmed publisher
    ..to leucine and codon 87 from aspartic acid to asparagine in GyrA and at codon 80 from serine to isoleucine in ParC. These isolates were genetically diverse in pulsotype analysis, lacked toxin genes of human pathogenic E...
  5. Harada K, Niina A, Shimizu T, Mukai Y, Kuwajima K, Miyamoto T, et al. Phenotypic and molecular characterization of antimicrobial resistance in Proteus mirabilis isolates from dogs. J Med Microbiol. 2014;63:1561-7 pubmed publisher
    ..9% of isolates. Quinolone-resistance determining regions (QRDRs) of gyrA and parC from 13 enrofloxacin-intermediate and -resistant isolates were sequenced...
  6. Anssour L, Messai Y, Estepa V, Torres C, Bakour R. Characteristics of ciprofloxacin-resistant Enterobacteriaceae isolates recovered from wastewater of an Algerian hospital. J Infect Dev Ctries. 2016;10:728-34 pubmed publisher
    ..A diversity in mutation patterns in gyrA and parC genes and new amino-acid substitutions in GyrA subunit were observed...
  7. Ferjani S, Saidani M, Maamar E, Harbaoui S, Hamzaoui Z, Hosni H, et al. Escherichia coli colonizing healthy children in Tunisia: High prevalence of extra-intestinal pathovar and occurrence of non-extended-spectrum-β-lactamase-producing ST131 clone. Int J Antimicrob Agents. 2018;52:878-885 pubmed publisher
    ..Amongst resistant quinolones isolated (n=5), chromosomal mutations in gyrA and parC genes were detected in four isolates and qnrS1 gene in two strains...
  8. Drlica K, Hiasa H, Kerns R, Malik M, Mustaev A, Zhao X. Quinolones: action and resistance updated. Curr Top Med Chem. 2009;9:981-98 pubmed
    ..Early studies suggested that drug binding occurs largely along helix-4 of the GyrA (gyrase) and ParC (topoisomerase IV) proteins...
  9. Casado Muñoz M, Benomar N, Lerma L, Galvez A, Abriouel H. Antibiotic resistance of Lactobacillus pentosus and Leuconostoc pseudomesenteroides isolated from naturally-fermented Aloreña table olives throughout fermentation process. Int J Food Microbiol. 2014;172:110-8 pubmed publisher
    ..g/ml), although no mutations in the quinolone resistance determining regions of the genes encoding GyrA and ParC were found, thus indicating an intrinsic resistance...

More Information

Publications88

  1. Das S, Samajpati S, Ray U, Roy I, Dutta S. Antimicrobial resistance and molecular subtypes of Salmonella enterica serovar Typhi isolates from Kolkata, India over a 15 years period 1998-2012. Int J Med Microbiol. 2017;307:28-36 pubmed publisher
    ..or resistance to ciprofloxacin had point mutation(s) in quinolone resistance-determining region of gyrA and parC genes. Pulsed-field gel electrophoresis showed more diversity among NALRS. Typhi than MDR strains...
  2. Capett M, Vollú Silva P, Melchiades V, Bokehi L, Araújo F, Martins I, et al. Characterization of Ciprofloxacin-Resistant and Ciprofloxacin-Susceptible Uropathogenic Escherichia coli Obtained from Patients with Gynecological Cancer. Curr Microbiol. 2016;73:624-632 pubmed publisher
    ..DNA mutations in gyrA were Ser-83-Leu and Asp-87-Asn and in parC were Ser-80-Ile and Glu-84-Val, Glu-84-Lys...
  3. Pitondo Silva A, Martins V, Silva C, Stehling E. Conjugation between quinolone-susceptible bacteria can generate mutations in the quinolone resistance-determining region, inducing quinolone resistance. Int J Antimicrob Agents. 2015;45:119-23 pubmed publisher
    ..Topoisomerase IV is a homologue of DNA gyrase and consists of two subunits codified by the parC and parE genes...
  4. Warner W, Kuang S, Hernandez R, Chong M, Ewing P, Fleischer J, et al. Molecular characterization and antimicrobial susceptibility of Acinetobacter baumannii isolates obtained from two hospital outbreaks in Los Angeles County, California, USA. BMC Infect Dis. 2016;16:194 pubmed publisher
    ..Resistance phenotypes of these strains to fluoroquinolones were correlated with point mutations in gyrA and parC genes that render reduced affinity to target proteins...
  5. Yang B, Zhao H, Cui S, Wang Y, Xia X, Xi M, et al. Prevalence and characterization of Salmonella enterica in dried milk-related infant foods in Shaanxi, China. J Dairy Sci. 2014;97:6754-60 pubmed publisher
    ..A (GyrA) were most frequently detected as Ser83Arg/Asp87Glu and in p53-associated Parkin-like cytoplasmic protein (ParC), they were all Ser80Arg; the quinolone resistance gene qnrS (47...
  6. Hooper D, Jacoby G. Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance. Cold Spring Harb Perspect Med. 2016;6: pubmed publisher
    ..mutations in one or both of the two drug target enzymes are commonly in a localized domain of the GyrA and ParC subunits of gyrase and topoisomerase IV, respectively, and reduce drug binding to the enzyme-DNA complex...
  7. El Tayeb M, Ibrahim A, Al Salamah A, Almaary K, Elbadawi Y. Prevalence, serotyping and antimicrobials resistance mechanism of Salmonella enterica isolated from clinical and environmental samples in Saudi Arabia. Braz J Microbiol. 2017;48:499-508 pubmed publisher
    ..On the other hand, fluoroquinolone resistance was related to the presence of mutations in gyrA and parC genes...
  8. Chang S, Lo D, Wei H, Kuo H. Antimicrobial resistance of Escherichia coli isolates from canine urinary tract infections. J Vet Med Sci. 2015;77:59-65 pubmed publisher
    ..Chromosomal point mutations were found in the GyrA (Ser83Leu) and ParC (Ser80Ile) genes...
  9. Salloum T, Tannous E, Alousi S, Arabaghian H, Rafei R, Hamze M, et al. Genomic mapping of ST85 blaNDM-1 and blaOXA-94 producing Acinetobacter baumannii isolates from Syrian Civil War Victims. Int J Infect Dis. 2018;74:100-108 pubmed publisher
    ..sub> GyrA (S83L) and ParC (S80L) substitutions conferred resistance to fluoroquinolones...
  10. Takeuchi N, Ohkusu M, Hoshino T, Naito S, Takaya A, Yamamoto T, et al. Emergence of quinolone-resistant strains in Streptococcus pneumoniae isolated from paediatric patients since the approval of oral fluoroquinolones in Japan. J Infect Chemother. 2017;23:218-223 pubmed publisher
    ..These strains were characterised based on quinolone resistance-determining regions (QRDRs), i.e. gyrA, gyrB, parC, and parE...
  11. Sun Y, Lu H, Zhang X, Wu Q, Bi W, Liu H, et al. Phenotype and genotype alteration during adaptive evolution of Enterococcus faecalis to antimicrobials. Infect Genet Evol. 2018;62:80-85 pubmed publisher
    ..analysis of quinolones resistance strains, amino acid changes were observed in the QRDR region of GyrA and ParC. Substitutions occurred at GyrA were detected as Ser84Asn/Ser84Ile/Ser84Arg/Gly106Asp...
  12. Furlan J, Stehling E. Draft genome sequence of a multidrug-resistant tetA/IncF-harbouring Escherichia coli ST906 obtained from a soil cultivated with jaboticaba (Plinia cauliflora). J Glob Antimicrob Resist. 2019;16:181-182 pubmed publisher
    ..Mutations in the quinolone resistance-determining region (QRDR) of GyrA, ParC and ParE were detected...
  13. Tomasić T, Masic L. Prospects for developing new antibacterials targeting bacterial type IIA topoisomerases. Curr Top Med Chem. 2014;14:130-51 pubmed
    ..The search for new GyrA and/or ParC inhibitors that can overcome the increasing spread of multidrug-resistant bacteria has been successfully focused in ..
  14. Kladsomboon S, Thippakorn C, Seesaard T. Development of Organic-Inorganic Hybrid Optical Gas Sensors for the Non-Invasive Monitoring of Pathogenic Bacteria. Sensors (Basel). 2018;18: pubmed publisher
    ..Based on a pattern recognition (PARC) technique, we showed that the proposed hybrid optical gas sensors can discriminate among the three pathogenic ..
  15. Metcalf B, Chochua S, Gertz R, Hawkins P, Ricaldi J, Li Z, et al. Short-read whole genome sequencing for determination of antimicrobial resistance mechanisms and capsular serotypes of current invasive Streptococcus agalactiae recovered in the USA. Clin Microbiol Infect. 2017;23:574.e7-574.e14 pubmed publisher
    ..6%) tetM-positive isolates were tetracycline-susceptible. All 53 fluoroquinolone-resistant isolates contained ParC and/or GyrA substitutions...
  16. Tian X, Zheng N, Han R, Ho H, Wang J, Wang Y, et al. Antimicrobial resistance and virulence genes of Streptococcus isolated from dairy cows with mastitis in China. Microb Pathog. 2019;131:33-39 pubmed publisher
    ..The gene combination of Sul1/Sul2/Sul3 + gyrA/parC + cat1/cat2 was the most common pattern (12.5%)...
  17. Woods S, Lieberman M, Lebreton F, Trowel E, de la Fuente Nunez C, Dzink Fox J, et al. Characterization of Multi-Drug Resistant Enterococcus faecalis Isolated from Cephalic Recording Chambers in Research Macaques (Macaca spp.). PLoS ONE. 2017;12:e0169293 pubmed publisher
    ..aac(6')-aph(2"), aph(3')-III, str, ant(6)-Ia, tetM, tetS, tetL, ermB, bcrABR, cat, and dfrG, and polymorphisms in parC (S80I) and gyrA (S83I) were observed...
  18. de Jong A, Muggeo A, El Garch F, Moyaert H, De Champs C, Guillard T. Characterization of quinolone resistance mechanisms in Enterobacteriaceae isolated from companion animals in Europe (ComPath II study). Vet Microbiol. 2018;216:159-167 pubmed publisher
    ..were screened for PMQR determinants (qnr, oqxAB, qepA and aac(6')-Ib-cr), and for QRDR mutations in gyrA, gyrB, parC and parE genes...
  19. Ferreira M, Dantas R, Faria A, Gonçalves I, Silveira de Brito C, Queiroz L, et al. Molecular epidemiological survey of the quinolone- and carbapenem-resistant genotype and its association with the type III secretion system in Pseudomonas aeruginosa. J Med Microbiol. 2015;64:262-71 pubmed publisher
    ..Our study showed a mutation at position 91 in the parC gene (Glu91Lys) associated with a mutation in gyrA (Thre83Ile) in a strain of extensively drug-resistant P...
  20. Chang B, Nariai A, Sekizuka T, Akeda Y, Kuroda M, Oishi K, et al. Capsule Switching and Antimicrobial Resistance Acquired during Repeated Streptococcus pneumoniae Pneumonia Episodes. J Clin Microbiol. 2015;53:3318-24 pubmed publisher
    ..in the wciP gene was presumed to relate to the serotype switching from 6B to 6A, and the other mutations in parC and gyrA were related to fluoroquinolone resistance. These results suggested that an S...
  21. McCurdy S, Lawrence L, Quintas M, Woosley L, Flamm R, Tseng C, et al. In Vitro Activity of Delafloxacin and Microbiological Response against Fluoroquinolone-Susceptible and Nonsusceptible Staphylococcus aureus Isolates from Two Phase 3 Studies of Acute Bacterial Skin and Skin Structure Infections. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..aureus isolates with the S84L mutation in gyrA and the S80Y mutation in parC, the most commonly observed mutations in global phase 3 studies...
  22. Veselkov D, Laponogov I, Pan X, Selvarajah J, Skamrova G, Branstrom A, et al. Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus pneumoniae complex. Acta Crystallogr D Struct Biol. 2016;72:488-96 pubmed publisher
    ..35 Å resolution. The complex is comprised of ParC breakage-reunion and ParE TOPRIM domains of K...
  23. Fookes M, Hadfield J, Harris S, Parmar S, Unemo M, Jensen J, et al. Mycoplasma genitalium: whole genome sequence analysis, recombination and population structure. BMC Genomics. 2017;18:993 pubmed publisher
    ..SNPs found in region V of 23S rRNA and parC were consistent with azithromycin/erythromycin and fluoroquinolone resistances, respectively, and with their ..
  24. Kubanov A, Vorobyev D, Chestkov A, Leinsoo A, Shaskolskiy B, Dementieva E, et al. Molecular epidemiology of drug-resistant Neisseria gonorrhoeae in Russia (Current Status, 2015). BMC Infect Dis. 2016;16:389 pubmed publisher
    ..criteria and an oligonucleotide microarray for the identification of mutations in the penA, ponA, rpsJ, gyrA and parC genes responsible for penicillin G, tetracycline, and fluoroquinolone resistance...
  25. Younas M, Siddiqui F, Noreen Z, Bokhari S, Gomez Duarte O, Wren B, et al. Characterization of enteropathogenic Escherichia coli of clinical origin from the pediatric population in Pakistan. Trans R Soc Trop Med Hyg. 2016;110:414-20 pubmed publisher
    ..Among nalidixic acid resistant isolates 13 (28%) showed presence of single nucleotide polymorphism (SNP) in parC (C330-T330) whereas 1 (2%) isolate showed gyrB (A660-T660) SNP. Furthermore, 27 (59%) isolates were ESBL producers...
  26. Piccinelli G, Biscaro V, Gargiulo F, Caruso A, De Francesco M. Characterization and antibiotic susceptibility of Streptococcus agalactiae isolates causing urinary tract infections. Infect Genet Evol. 2015;34:1-6 pubmed publisher
    ..Levofloxacin resistance was linked to mutations in gyrA and parC genes. Predominant capsular types were III, Ia, V, Ib and IX...
  27. Chen D, Wen S, Feng D, Xu R, Liu J, Peters B, et al. Microbial virulence, molecular epidemiology and pathogenic factors of fluoroquinolone-resistant Haemophilus influenzae infections in Guangzhou, China. Ann Clin Microbiol Antimicrob. 2018;17:41 pubmed publisher
    ..in gyrA and one amino acid substitution in the QRDR of gyrA linked with one amino acid substitution in the QRDR of parC, respectively. In addition, five sequence types (ST) were identified, with ST1719 firstly found...
  28. Zhu Z, Shi Y, Zhou X, Li B, Zhang J. Molecular characterization of fluoroquinolone and/or cephalosporin resistance in Shigella sonnei isolates from yaks. BMC Vet Res. 2018;14:177 pubmed publisher
    ..region (QRDR) genes, we identified double mutations in gyrA (Ser83-Leu and Asp87-Asn) and a single mutation in parC (Ser80-Ile). All 12 fluoroquinolone-resistant S...
  29. Bai L, Zhao J, Gan X, Wang J, Zhang X, Cui S, et al. Emergence and Diversity of Salmonella enterica Serovar Indiana Isolates with Concurrent Resistance to Ciprofloxacin and Cefotaxime from Patients and Food-Producing Animals in China. Antimicrob Agents Chemother. 2016;60:3365-71 pubmed publisher
    ..resistance [qepA, oqxAB, and aac(6')-Ib-cr] with mutations in topoisomerase-encoding genes (gyrA and parC) and several ESBLs (including CTX-M-65, CTX-M-27, CTX-M-15, CTX-M-14, and CTX-M-14/CTX-M-15) were noteworthy...
  30. Puig C, Tirado Vélez J, Calatayud L, Tubau F, Garmendia J, Ardanuy C, et al. Molecular characterization of fluoroquinolone resistance in nontypeable Haemophilus influenzae clinical isolates. Antimicrob Agents Chemother. 2015;59:461-6 pubmed publisher
    ..In the NTHi isolates studied, two mutations producing changes in two GyrA residues (Ser84, Asp88) and/or two ParC residues (Ser84, Glu88) were associated with increased fluoroquinolone MICs...
  31. Asadpour L. Antimicrobial resistance, biofilm-forming ability and virulence potential of Pseudomonas aeruginosa isolated from burn patients in northern Iran. J Glob Antimicrob Resist. 2018;13:214-220 pubmed publisher
    ..The frequency of biofilm- and virulence-associated genes was investigated by PCR. Mutations in gyrA and parC in ciprofloxacin-resistant isolates were also determined by PCR. In phenotypic assays, 72.2% (65/90) of P...
  32. Zawadzki P, Stracy M, Ginda K, Zawadzka K, Lesterlin C, Kapanidis A, et al. The Localization and Action of Topoisomerase IV in Escherichia coli Chromosome Segregation Is Coordinated by the SMC Complex, MukBEF. Cell Rep. 2015;13:2587-2596 pubmed publisher
    ..Finally, we show that the MukB-ParC interaction is crucial for timely decatenation and segregation of newly replicated ori DNA.
  33. Hasan M, Seo J, Rahaman K, Min H, Kim K, Park J, et al. Novel genes in brain tissues of EAE-induced normal and obese mice: Upregulation of metal ion-binding protein genes in obese-EAE mice. Neuroscience. 2017;343:322-336 pubmed publisher
    ..The genes related with metal ion-binding proteins were upregulated in HFD-EAE and ND-EAE mice. Upregulation of Cul9, Mast2, and C4b expression is significantly higher in HFD-EAE mice than ND-EAE mice...
  34. Thai V, Pham H, Nguyen D, Lambert P, Nguyen T. A deletion mutation in nfxB of in vitro-induced moxifloxacin-resistant Pseudomonas aeruginosa confers multidrug resistance. Acta Microbiol Immunol Hung. 2017;64:245-253 pubmed publisher
    ..No mutation was observed for FQ-target (gyrA and parC) or most investigated efflux regulatory genes (mexT, mexR, and nalC) except nfxB in which a 100-bp deletion was ..
  35. Li F, Zhou F, Huang M, Gong H, Xu R. Frequency-Specific Abnormalities of Intrinsic Functional Connectivity Strength among Patients with Amyotrophic Lateral Sclerosis: A Resting-State fMRI Study. Front Aging Neurosci. 2017;9:351 pubmed publisher
    ..FCS in the left lingual gyrus, as well as increased FCS in the left postcentral gyrus/paracentral lobule (PoCG/PARC). In the slow-4 band, the ALS patients presented decreased FCS in the left and right ventrolateral PFC...
  36. Takata I, Yamagishi Y, Mikamo H. Association of the exoU genotype with a multidrug non-susceptible phenotype and mRNA expressions of resistance genes in Pseudomonas aeruginosa. J Infect Chemother. 2018;24:45-52 pubmed publisher
    ..The imp carbapenemase genotype, the quinolone-resistance-determining region mutation in GyrA and ParC and the defective mutation in OprD were not frequently found in the exoU + genotype and carbapenem and ..
  37. Becker K, Marchenko N, Maurice M, Moll U. Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma. Cell Death Differ. 2007;14:1350-60 pubmed
    ..Moreover, nutlin and camptothecin act synergistically in inducing NB cell apoptosis. Hence, this study strengthens the rationale for targeting p53 deubiquitylation by drugs like Nutlin as a promising new strategy in NB therapy. ..
  38. Moynihan T, Ardley H, Nuber U, Rose S, Jones P, Markham A, et al. The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1. J Biol Chem. 1999;274:30963-8 pubmed
  39. Pei X, Bai F, Li Z, Smith M, Whitewolf G, Jin R, et al. Cytoplasmic CUL9/PARC ubiquitin ligase is a tumor suppressor and promotes p53-dependent apoptosis. Cancer Res. 2011;71:2969-77 pubmed publisher
    ..Here, we report that deletion of the Cul9 (formerly Parc) gene, which encodes an E3 ubiquitin ligase that binds to p53 and localizes in the cytoplasm, ..
  40. Coffill C, Muller P, Oh H, Neo S, Hogue K, Cheok C, et al. Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. EMBO Rep. 2012;13:638-44 pubmed publisher
    ..Advanced proteomics has thus allowed the detection of a new mechanism of p53-driven invasion. ..
  41. Na S, Jeon H, Kim Y, Kwon H, Selasi G, Nicholas A, et al. Antimicrobial activity of novel 4H-4-oxoquinolizine compounds against extensively drug-resistant Acinetobacter baumannii strains. Int J Antimicrob Agents. 2017;49:107-111 pubmed publisher
    ..02-1.70?µg/mL regardless of the mutation types in the quinolone resistance-determining region (QRDR) of GyrA and ParC. Cytotoxicity of the seven compounds was observed in HeLa and U937 cells at a concentration of 50?µg/mL, which was ..
  42. Yang H, Kim Y, Cho S, Nam Y, Oh T, Park K, et al. Fluoroquinolone Resistance Mechanisms by Molecular Epidemiologic Study of Ciprofloxacin-Nonsusceptible Escherichia coli Sequence Types Isolated from Clinical Specimens in a Tertiary Care University Hospital in Korea: Emergence of Clone ST131, 2006-20. Ann Clin Lab Sci. 2017;47:511-515 pubmed
    ..The prevalence of fluoroquinolone resistance-determining region (QRDR) mutations in gyrA, gyrB, parC, and parE and plasmid-mediated quinolone resistance (PMQR) genes were also studied...
  43. Kasper J, Arai T, DeCaprio J. A novel p53-binding domain in CUL7. Biochem Biophys Res Commun. 2006;348:132-8 pubmed
    ..CUL7 is required for normal mouse embryonic development and cellular proliferation, and is highly homologous to PARC, a p53-associated, parkin-like cytoplasmic protein...
  44. Li Z, Pei X, Yan J, Yan F, Cappell K, Whitehurst A, et al. CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity. Mol Cell. 2014;54:805-19 pubmed publisher
    The Cullin 9 (CUL9) gene encodes a putative E3 ligase that localizes in the cytoplasm...
  45. Skaar J, Arai T, DeCaprio J. Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development. Mol Cell Biol. 2005;25:5579-89 pubmed
    ..The p53-associated, parkin-like cytoplasmic protein (PARC), a homolog of CUL7, was identified as a CUL7-interacting protein by mass spectrometry...
  46. Braam J, van Dommelen L, Henquet C, Van De Bovenkamp J, Kusters J. Multidrug-resistant Mycoplasma genitalium infections in Europe. Eur J Clin Microbiol Infect Dis. 2017;36:1565-1567 pubmed publisher
    ..A urogenital sample was used to determine the sequence of the 23S rRNA, gyrA, gyrB and parC genes...
  47. Tatay Dualde J, Prats van der Ham M, de la Fe C, Paterna A, Sánchez A, Corrales J, et al. Mutations in the quinolone resistance determining region conferring resistance to fluoroquinolones in Mycoplasma agalactiae. Vet Microbiol. 2017;207:63-68 pubmed publisher
    ..mutants against enrofloxacin, marbofloxacin and moxifloxacin and afterwards, partial sequences of their gyrA, gyrB, parC and parE genes were analyzed. In addition, a set of field isolates with different MIC values were also studied...
  48. Issaeva N, Bozko P, Enge M, Protopopova M, Verhoef L, Masucci M, et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat Med. 2004;10:1321-8 pubmed
    ..RITA may serve as a lead compound for the development of an anticancer drug that targets tumors with wild-type p53. ..
  49. Li Z, Xiong Y. Cytoplasmic E3 ubiquitin ligase CUL9 controls cell proliferation, senescence, apoptosis and genome integrity through p53. Oncogene. 2017;36:5212-5218 pubmed publisher
    b>CUL9 is a member of the cullin family of E3 ubiquitin ligases, and it localizes predominantly in the cytoplasm...
  50. Wu J, Lan F, Lu Y, He Q, Li B. Molecular Characteristics of ST1193 Clone among Phylogenetic Group B2 Non-ST131 Fluoroquinolone-Resistant Escherichia coli. Front Microbiol. 2017;8:2294 pubmed publisher
    ..conserved mutations defining quinolone-resistance determining region substitutions (gyrA S83L, D87N, and parC S80I). The most frequent VF genes detected in these E...
  51. Giraldo P, Andrade Campos M, Alfonso P, Irún P, Atutxa K, Acedo A, et al. Twelve years of experience with miglustat in the treatment of type 1 Gaucher disease: The Spanish ZAGAL project. Blood Cells Mol Dis. 2018;68:173-179 pubmed publisher
    ..In total, 80% of patients achieved current GD1 therapeutic goals. Plasma chitotriosidase activity and CCL-18/PARC concentration showed a trend towards a slight increase. Reductions on S-MRI (p=0...
  52. Vitali R, Cesi V, Tanno B, Ferrari Amorotti G, Dominici C, Calabretta B, et al. Activation of p53-dependent responses in tumor cells treated with a PARC-interacting peptide. Biochem Biophys Res Commun. 2008;368:350-6 pubmed publisher
    We tested the activity of a p53 carboxy-terminal peptide containing the PARC-interacting region in cancer cells with wild type cytoplasmic p53...
  53. Rosnes J, Valego N, Wang J, Perez F, Rose J. Renal mRNA response to reduced perfusion pressure conserved despite denervation in mature ovine fetuses. Am J Physiol Regul Integr Comp Physiol. 2001;280:R1830-6 pubmed
    ..Femoral arterial blood pressure (FAB) and plasma active renin (pARC) and prorenin (pPRC) concentrations were obtained hourly for 6 h and at h 23 and 24...
  54. Perkins P. Hydraenidae of Madagascar (Insecta: Coleoptera). Zootaxa. 2017;4342:1-264 pubmed publisher
    ..parvipalpis (Antananarivo, Réserve Spéciale d'Ambohitantely); H. rubridentata ((Mahajanga, Parc National de Namoroka); H. serripennis (Antsiranana, Forêt d' Antsahabe). New species of Hydraena (Monomadraena): H...
  55. Leinsoo A, Shaskol skii B, Dement eva E, Gryadunov D, Kubanov A, Chestkov A, et al. Oligonucleotide Microchip for the Identification of Infectious Agents of Reproductive System with Simultaneous Analysis of Determinants of Resistance to Antimicrobial Substances. Bull Exp Biol Med. 2017;164:54-60 pubmed publisher
    ..Mycoplasma spp. The N. gonorrhoeae isolates had multiple mutations in the penA, ponA, rpsJ, gyrA, parC, and mtrR genes; their prognostic value significantly increased when combinations of mutations were detected...
  56. Ben Nejma M, Sioud O, Mastouri M. Quinolone-resistant clinical strains of Pseudomonas aeruginosa isolated from University Hospital in Tunisia. 3 Biotech. 2018;8:1 pubmed publisher
    ..this study, we examined mutations in the quinolone resistance-determining regions (QRDRs) of the gyrA and parC genes of Pseudomonas aeruginosa (P...
  57. Gama V, Swahari V, Schafer J, Kole A, Evans A, Huang Y, et al. The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells. Sci Signal. 2014;7:ra67 pubmed publisher
    ..screen in U-87 MG glioma cells identified p53-associated Parkin-like cytoplasmic protein (PARC, also known as CUL9) as an E3 ligase that targets Cyt c for degradation...
  58. Rebbah N, Messai Y, Châtre P, Haenni M, Madec J, Bakour R. Diversity of CTX-M Extended-Spectrum ?-Lactamases in Escherichia coli Isolates from Retail Raw Ground Beef: First Report of CTX-M-24 and CTX-M-32 in Algeria. Microb Drug Resist. 2017;: pubmed publisher
    ..Sequence analysis of gyrA and parC genes showed mutations in 98.6% of ciprofloxacin-resistant isolates. The patterns "GyrA: S83L+D87N, ParC: S80I" (46...
  59. Sood S, Agarwal M, Bala M, Mahajan N, Singh R, Kapil A, et al. Exploring quinolone resistance-determining region in Neisseria gonorrhoeae isolates from across India. Indian J Med Res. 2017;146:S64-S69 pubmed publisher
    ..present study was undertaken to examine the rates of ciprofloxacin resistance, to correlate mutations in gyrA and parC genes with the level of resistance and to look for a variation in mutation pattern, if any, in isolates from across ..
  60. Nikolaev A, Li M, Puskas N, Qin J, Gu W. Parc: a cytoplasmic anchor for p53. Cell. 2003;112:29-40 pubmed
    Nuclear localization of p53 is essential for its tumor suppressor function. Here, we have identified Parc, a Parkin-like ubiquitin ligase, as a cytoplasmic anchor protein in p53-associated protein complexes...
  61. Piccinelli G, Gargiulo F, Biscaro V, Caccuri F, Caruso A, De Francesco M. Analysis of mutations in DNA gyrase and topoisomerase IV of Ureaplasma urealyticum and Ureaplasma parvum serovars resistant to fluoroquinolones. Infect Genet Evol. 2017;47:64-67 pubmed publisher
    ..However, only 43 out of 85 quinolone resistant isolates had amino acid substitutions in GyrA, GyrB, ParC and ParE proteins underlining that this assay have mis-identified as fluoroquinolone resistant 42 isolates...
  62. Valentine King M, Brown M. Antibacterial Resistance in Ureaplasma Species and Mycoplasma hominis Isolates from Urine Cultures in College-Aged Females. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..identified tetM to be present in the tetracycline-resistant isolate and an S83W mutation within the parC gene of the quinolone-resistant isolate...
  63. Hadad R, Golparian D, Lagos A, Ljungberg J, Nilsson P, Jensen J, et al. Macrolide and fluoroquinolone resistance in Mycoplasma genitalium in two Swedish counties, 2011-2015. APMIS. 2017;: pubmed publisher
    ..In total, 672 M. genitalium positive urogenital samples were sequenced for 23S rRNA and parC gene mutations associated with macrolide and fluoroquinolone resistance, respectively. Of the samples, 18.6% and 3...
  64. Kondo H, Ito S, Hatazaki K, Horie K, Nakane K, Mizutani K, et al. GyrA and/or ParC alterations of Haemophilus influenzae strains isolated from the urethra of men with acute urethritis. J Infect Chemother. 2018;24:232-235 pubmed publisher
    ..We amplified the quinolone resistance-determining region of the gyrA gene and the analogous region of the parC gene from bacterial DNAs by PCR and sequenced the PCR products. Two strains with a LVFX MIC of 0...
  65. Woo M, Xue K, Liu J, McBride H, Tsang B. Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking. J Biol Chem. 2012;287:3963-75 pubmed publisher
    ..b>PARC is a cytoplasmic protein regulating p53 subcellular localization and subsequent function...
  66. Cereser A, Strobl M, Hall S, Steuwer A, Kiyanagi R, Tremsin A, et al. Time-of-Flight Three Dimensional Neutron Diffraction in Transmission Mode for Mapping Crystal Grain Structures. Sci Rep. 2017;7:9561 pubmed publisher
    ..data collected at the Materials and Life Science Experimental Facility of the Japan Proton Accelerator Complex (J-PARC) for an iron sample. We successfully reconstructed the shape of 108 grains and developed an indexing procedure...
  67. Skaar J, Florens L, Tsutsumi T, Arai T, Tron A, Swanson S, et al. PARC and CUL7 form atypical cullin RING ligase complexes. Cancer Res. 2007;67:2006-14 pubmed
    CUL7 and the p53-associated, PARkin-like cytoplasmic protein (PARC) were previously reported to form homodimers and heterodimers, the first demonstration of cullin dimerization...
  68. Kaustov L, Lukin J, Lemak A, Duan S, Ho M, Doherty R, et al. The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53. J Biol Chem. 2007;282:11300-7 pubmed
    ..Recently, a region of Cul7 that is highly conserved in the p53-associated, Parkin-like cytoplasmic protein PARC, was shown to bind p53 directly...
  69. Lecompte V, Rousseau C. Determinants of Child Attachment in the Years Postpartum in a High-Risk Sample of Immigrant Women. J Immigr Minor Health. 2018;20:1166-1172 pubmed publisher
    ..and their child (Mage = 37 months) were recruited through a Health and Social Service organization in the Parc-Extension neighborhood in Montreal, Quebec...
  70. Lluque A, Riveros M, Prada A, Ochoa T, Ruiz J. Virulence and Antimicrobial Resistance in Campylobacter spp. from a Peruvian Pediatric Cohort. Scientifica (Cairo). 2017;2017:7848926 pubmed publisher
    ..The presence of mutations in the gyrA, parC, and 23S rRNA genes was determined...
  71. Zhu Y, Lai H, Zou L, Yin S, Wang C, Han X, et al. Antimicrobial resistance and resistance genes in Salmonella strains isolated from broiler chickens along the slaughtering process in China. Int J Food Microbiol. 2017;259:43-51 pubmed publisher
    ..the presence of class 1 integron as well as the associated gene cassettes, and the mutations within the gyrA and parC genes. Consequently, the prevalence of Salmonella was 30.14% (47.96% for cecal content, 18...
  72. Lopez J, Tait S. Killing the Killer: PARC/CUL9 promotes cell survival by destroying cytochrome C. Sci Signal. 2014;7:pe17 pubmed publisher
    ..In an unbiased approach, PARC (also known as CUL9) was found to be the ubiquitin ligase responsible for the ubiquitination and proteasomal ..
  73. Alvarado A, Kjær A, Yang W, Mann P, Briegel A, Waldor M, et al. Coupling chemosensory array formation and localization. elife. 2017;6: pubmed publisher
    ..Proper localization of signaling arrays is mediated by ParP, which tethers arrays to a cell pole anchor, ParC. Here we show that ParP's C-terminus integrates into the core-unit of signaling arrays through interactions with ..
  74. Butjosa A, Gomez Benito J, Myin Germeys I, Barajas A, Baños I, Usall J, et al. Development and validation of the Questionnaire of Stressful Life Events (QSLE). J Psychiatr Res. 2017;95:213-223 pubmed publisher
    ..In Study 1, an over-inclusive item pool was generated based on review of group of experts at Parc Sanitari Sant Joan de Déu and content validity was examined by an Expert Survey...
  75. Dowell J, Tsai S, Dias Santagata D, Nakajima H, Wang Z, Zhu W, et al. Expression of a mutant p193/CUL7 molecule confers resistance to MG132- and etoposide-induced apoptosis independent of p53 or Parc binding. Biochim Biophys Acta. 2007;1773:358-66 pubmed
    ..Immune precipitation/Western analyses revealed that endogenous p193/CUL7 formed a complex with Parc (a recently identified parkin-like ubiquitin ligase) and p53...
  76. Faccone D, Lopez Ruitti P, Vazquez M, Guerriero L, Lucero C, Gagetti P, et al. Molecular characterization of a clinical Haemophilus parainfluenzae isolate with cefotaxime resistance and decreased susceptibility to fluoroquinolones. Infect Genet Evol. 2016;44:507-509 pubmed publisher
    ..MIC of ciprofloxacin was 0.5mg/L, and substitutions in gyrA (Ser84Tyr) and parC (Ser84Phe) genes were detected.
  77. Kawasaki Y, Matsubara K, Takahashi H, Morita M, Ohnishi M, Hori M, et al. Invasive meningococcal disease due to ciprofloxacin-resistant Neisseria meningitidis sequence type 4821: The first case in Japan. J Infect Chemother. 2018;24:305-308 pubmed publisher
    ..The isolate harbored gyrA T91I and parC S87I mutations at the quinolone-resistance-determining regions...
  78. Wan T, Naoe T, Wakui T, Futakawa M, Obayashi H, Sasa T. Effects of Grain Size on Ultrasonic Attenuation in Type 316L Stainless Steel. Materials (Basel). 2017;10: pubmed publisher
    ..target will be installed in the Target Test Facility (TEF-T) in the Japan Proton Accelerator Research Complex (J-PARC). The spallation target vessel filled with LBE is made of type 316L stainless steel...
  79. Ko H, Kim S, Sriram S, Dawson V, Dawson T. Identification of far upstream element-binding protein-1 as an authentic Parkin substrate. J Biol Chem. 2006;281:16193-6 pubmed