CUL7

Summary

Gene Symbol: CUL7
Description: cullin 7
Alias: 3M1, CUL-7, KIAA0076, dJ20C7.5, cullin-7
Species: human
Products:     CUL7

Top Publications

  1. Gascoin Lachambre G, Buffat C, Rebourcet R, Chelbi S, Rigourd V, Mondon F, et al. Cullins in human intra-uterine growth restriction: expressional and epigenetic alterations. Placenta. 2010;31:151-7 pubmed publisher
    ..Our work hypothesis is that Cullins, particularly CUL4B and CUL7, are involved in placental diseases and especially in IUGR...
  2. Hanson D, Murray P, O Sullivan J, Urquhart J, Daly S, Bhaskar S, et al. Exome sequencing identifies CCDC8 mutations in 3-M syndrome, suggesting that CCDC8 contributes in a pathway with CUL7 and OBSL1 to control human growth. Am J Hum Genet. 2011;89:148-53 pubmed publisher
    3-M syndrome, a primordial growth disorder, is associated with mutations in CUL7 and OBSL1. Exome sequencing now identifies mutations in CCDC8 as a cause of 3-M syndrome...
  3. Hanson D, Murray P, Black G, Clayton P. The genetics of 3-M syndrome: unravelling a potential new regulatory growth pathway. Horm Res Paediatr. 2011;76:369-78 pubmed publisher
    ..recessive primordial growth disorder characterised by severe postnatal growth restriction caused by mutations in CUL7, OBSL1 or CCDC8...
  4. Okabe H, Lee S, Phuchareon J, Albertson D, McCormick F, Tetsu O. A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. PLoS ONE. 2006;1:e128 pubmed
    ..Thus, FBXW8 plays an essential role in cancer cell proliferation through proteolysis of cyclin D1. It may present new opportunities to develop therapies targeting destruction of cyclin D1 or its regulator E3 ligase selectively. ..
  5. Kaustov L, Lukin J, Lemak A, Duan S, Ho M, Doherty R, et al. The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53. J Biol Chem. 2007;282:11300-7 pubmed
    b>Cul7 is a member of the Cullin Ring Ligase (CRL) family and is required for normal mouse development and cellular proliferation...
  6. Litterman N, Ikeuchi Y, Gallardo G, O Connell B, Sowa M, Gygi S, et al. An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning. PLoS Biol. 2011;9:e1001060 pubmed publisher
    ..Here, we report that the E3 ubiquitin ligase Cul7(Fbxw8) localizes to the Golgi complex in mammalian brain neurons...
  7. Huber C, Delezoide A, Guimiot F, Baumann C, Malan V, Le Merrer M, et al. A large-scale mutation search reveals genetic heterogeneity in 3M syndrome. Eur J Hum Genet. 2009;17:395-400 pubmed publisher
    The 3M syndrome is a rare autosomal recessive disorder recently ascribed to mutations in the CUL7 gene and characterized by severe pre- and postnatal growth retardation...
  8. Xu X, Sarikas A, Dias Santagata D, Dolios G, Lafontant P, Tsai S, et al. The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. Mol Cell. 2008;30:403-14 pubmed publisher
    Recent genetic studies have documented a pivotal growth-regulatory role played by the Cullin 7 (CUL7) E3 ubiquitin ligase complex containing the Fbw8-substrate-targeting subunit, Skp1, and the ROC1 RING finger protein...
  9. Tsutsumi T, Kuwabara H, Arai T, Xiao Y, DeCaprio J. Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice. Mol Cell Biol. 2008;28:743-51 pubmed
    b>CUL7 binds to SKP1, RBX1, and FBXW8 to form a cullin-RING ligase, or an SKP1-cullin-F box protein complex. The targeted disruption of the Cul7 gene in mice results in significant reduction in embryo size and neonatal lethality...

More Information

Publications60

  1. Arai T, Kasper J, Skaar J, Ali S, Takahashi C, DeCaprio J. Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. Proc Natl Acad Sci U S A. 2003;100:9855-60 pubmed
    ..A Cul1 homologue, p185 (Cul7), has been isolated as an simian virus 40 large T antigen-binding protein...
  2. Dias D, Dolios G, Wang R, Pan Z. CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. Proc Natl Acad Sci U S A. 2002;99:16601-6 pubmed
    ..alternative mechanism for assembling an F-box protein-based E3 complex through a previously uncharacterized cullin, CUL7, identified by mass spectrometry as a ROC1-interacting protein...
  3. Hanson D, Murray P, Coulson T, Sud A, Omokanye A, Stratta E, et al. Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling. J Mol Endocrinol. 2012;49:267-75 pubmed publisher
    3-M syndrome is a primordial growth disorder caused by mutations in CUL7, OBSL1 or CCDC8. 3-M patients typically have a modest response to GH treatment, but the mechanism is unknown...
  4. Maksimova N, Hara K, Miyashia A, Nikolaeva I, Shiga A, Nogovicina A, et al. Clinical, molecular and histopathological features of short stature syndrome with novel CUL7 mutation in Yakuts: new population isolate in Asia. J Med Genet. 2007;44:772-8 pubmed
    ..as the identical loci responsible for 3-M and gloomy face syndromes and a novel homozygous 4582insT mutation in Cullin 7 (CUL7) was found, which resulted in a frameshift mutation and the formation of a subsequent premature stop codon ..
  5. Huber C, Dias Santagata D, Glaser A, O Sullivan J, Brauner R, Wu K, et al. Identification of mutations in CUL7 in 3-M syndrome. Nat Genet. 2005;37:1119-24 pubmed
    ..1 and then identified 25 distinct mutations in the gene cullin 7 (CUL7)...
  6. Shaikh S, Shettigar S, Kumar S, Kantharia S, Kurva J, Cherian S. Novel mutation in Cul7 gene in a family diagnosed with 3M syndrome. J Genet. 2019;98: pubmed
    ..i>CUL7 was one of the 141 genes present in this region...
  7. Scheufele F, Wolf B, Kruse M, Hartmann T, Lempart J, Mühlich S, et al. Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling. Cell Signal. 2014;26:233-239 pubmed publisher
    ..We show that Cul7(-/-) mouse embryonic fibroblasts displayed enhanced AKT and Erk MAP kinase phosphorylation upon insulin stimulation...
  8. Nie J, Xu C, Jin J, Aka J, Tempel W, Nguyen V, et al. Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8. Structure. 2015;23:700-12 pubmed publisher
    ..Two other genes mutated in this syndrome encode CUL7 and OBSL1. While CUL7 is a ubiquitin ligase and OBSL1 associates with the cytoskeleton, little is known about CCDC8...
  9. You J, Wang L, Huang J, Jiang M, Chen Q, Wang Y, et al. Low glucose transporter SLC2A5-inhibited human normal adjacent lung adenocarcinoma cytoplasmic pro-B cell development mechanism network. Mol Cell Biochem. 2015;399:71-6 pubmed publisher
    ..databases, our result showed that low SLC2A5-inhibited network included Golgi apparatus of AP1M2_1; cell cycle of CUL7, SAC3D1; protein amino acid dephosphorylation of STYXL1; pro-B cell-cell differentiation of SOX4_3; and FAD ..
  10. Storr H, Dunkel L, Kowalczyk J, Savage M, Metherell L. Genetic characterisation of a cohort of children clinically labelled as GH or IGF1 insensitive: diagnostic value of serum IGF1 and height at presentation. Eur J Endocrinol. 2015;172:151-61 pubmed publisher
    ..sequenced appropriate candidate genes (GHR, including its pseudoexon (6Ψ), STAT5B, IGFALS, IGF1, IGF1R, OBSL1, CUL7 and CCDC8) in subjects referred with suspected GHI (n=69) or IGF1 insensitivity (n=3). Mean serum IGF1 SDS was -2...
  11. Chen P, Yao G. The role of cullin proteins in gastric cancer. Tumour Biol. 2016;37:29-37 pubmed publisher
    ..There are seven cullin proteins that have been identified in eukaryotes: CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, and CUL7/p53-associated parkin-like cytoplasmic protein...
  12. Shah V, Maddika S. CRL7SMU1 E3 ligase complex-driven H2B ubiquitylation functions in sister chromatid cohesion by regulating SMC1 expression. J Cell Sci. 2018;131: pubmed publisher
    ..We demonstrate that SMU1, DDB1, CUL7 and RNF40 are integral components of this complex...
  13. Wei M, Zhao X, Liu M, Huang Z, Xiao Y, Niu M, et al. Inhibition of HIV-1 assembly by coiled-coil domain containing protein 8 in human cells. Sci Rep. 2015;5:14724 pubmed publisher
    ..CCDC8, along with cytoskeleton protein obscuring-like1 (Obsl1) and E3 ligase Cul7, induces Gag polyubiquitination and degradation...
  14. Hsu P, Ma Y, Fang Y, Huang J, Gan Y, Chang P, et al. Cullin 7 mediates proteasomal and lysosomal degradations of rat Eag1 potassium channels. Sci Rep. 2017;7:40825 pubmed publisher
    ..Herein we aim to ascertain the protein degradation mechanism of rat Eag1 (rEag1). We identified cullin 7 (Cul7), a member of the cullin-based E3 ubiquitin ligase family, as a novel rEag1 binding partner...
  15. Kong C, Lange J, Samovski D, Su X, Liu J, Sundaresan S, et al. Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is regulated by protein palmitoylation. Biochem Biophys Res Commun. 2013;434:388-93 pubmed publisher
    ..Recently we documented the role of CUL7 E3 ligase in growth factors-induced ubiquitination and degradation of TBC1D3...
  16. Kim K, Jeon M, Lee H, Park J, Moon S, Kim S, et al. Comparative analysis of secretory factors from permanent- and deciduous-teeth periodontal ligament cells. Arch Oral Biol. 2016;71:65-79 pubmed publisher
    ..and catalytic activities (matrix metallopeptidase 1 (MMP1), Proteasome subunit, alpha type, 1 (PSMA1), and cullin 7 (CUL7)) were higher in D-PDL-CM...
  17. Fu J, Lv X, Lin H, Wu L, Wang R, Zhou Z, et al. Ubiquitin ligase cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells. J Biol Chem. 2010;285:10870-9 pubmed publisher
    Germ line mutations of the ubiquitin ligase cullin 7 (CUL7) are linked to 3-M syndrome and Yakuts short stature syndrome, both of which are characterized by pre- and post-natal growth retardation...
  18. Paradis V, Albuquerque M, Mebarki M, Hernandez L, Zalinski S, Quentin S, et al. Cullin7: a new gene involved in liver carcinogenesis related to metabolic syndrome. Gut. 2013;62:911-9 pubmed publisher
    ..1 amplicon in HCC/MS. Increased expression of cullin7 (CUL7), a gene located at the 6p21.1 locus, was demonstrated in HCC with the 6p21...
  19. Andrews P, He Y, Xiong Y. Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function. Oncogene. 2006;25:4534-48 pubmed
    ..b>CUL7 mediates an essential function for mouse embryo development and has been linked with cell transformation by its ..
  20. Skaar J, Florens L, Tsutsumi T, Arai T, Tron A, Swanson S, et al. PARC and CUL7 form atypical cullin RING ligase complexes. Cancer Res. 2007;67:2006-14 pubmed
    b>CUL7 and the p53-associated, PARkin-like cytoplasmic protein (PARC) were previously reported to form homodimers and heterodimers, the first demonstration of cullin dimerization...
  21. Li D, Liu S, Zhu L, Wang Y, Chen Y, Liu J, et al. FBXW8-dependent degradation of MRFAP1 in anaphase controls mitotic cell death. Oncotarget. 2017;8:97178-97186 pubmed publisher
    ..MRFAP1 is degraded by means of the ubiquitin ligase Cul7/FBXW8 during mitotic anaphase-telophase transition and accumulated in mitotic metaphase...
  22. Jung P, Verdoodt B, Bailey A, Yates J, Menssen A, Hermeking H. Induction of cullin 7 by DNA damage attenuates p53 function. Proc Natl Acad Sci U S A. 2007;104:11388-93 pubmed
    ..In a proteomic screen for p53 interactors, we found that the cullin protein Cul7 efficiently associates with p53...
  23. An J, Liu Z, Liang Q, Pan Y, Li H, Wang R, et al. Overexpression of Rabl3 and Cullin7 is associated with pathogenesis and poor prognosis in hepatocellular carcinoma. Hum Pathol. 2017;67:146-151 pubmed publisher
  24. Li Z, Pei X, Yan J, Yan F, Cappell K, Whitehurst A, et al. CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity. Mol Cell. 2014;54:805-19 pubmed publisher
    ..CUL9 knockdown rescues the microtubule and mitosis defects in cells depleted for CUL7 or OBSL1, two genes that are mutated in a mutually exclusive manner in 3M growth retardation syndrome and function ..
  25. Yan J, Yan F, Li Z, Sinnott B, Cappell K, Yu Y, et al. The 3M complex maintains microtubule and genome integrity. Mol Cell. 2014;54:791-804 pubmed publisher
    b>CUL7, OBSL1, and CCDC8 genes are mutated in a mutually exclusive manner in 3M and other growth retardation syndromes. The mechanism underlying the function of the three 3M genes in development is not known...
  26. Skaar J, Arai T, DeCaprio J. Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development. Mol Cell Biol. 2005;25:5579-89 pubmed
    b>CUL7, a recently identified member of the cullin family of E3 ubiquitin ligases, forms a unique SCF-like complex and is required for mouse embryonic development...
  27. Mao X, Gluck N, Chen B, Starokadomskyy P, Li H, Maine G, et al. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. J Biol Chem. 2011;286:32355-65 pubmed publisher
    ..These findings highlight a novel mechanism of CRL activation and suggest that CRL regulation may underlie the pleiotropic activities of COMMD1. ..
  28. Nie L, Zhao Y, Wu W, Yang Y, Wang H, Sun X. Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes. Cell Res. 2011;21:754-69 pubmed publisher
  29. Wen H, Kim N, Fuentes E, Mallinger A, Gonzalez Alegre P, Glenn K. FBG1 is a promiscuous ubiquitin ligase that sequesters APC2 and causes S-phase arrest. Cell Cycle. 2010;9:4506-17 pubmed
    ..In summary, we have discovered a novel APC2 inhibitory activity of FBG1 independent from its function as ubiquitin ligase, providing the basis for future studies of FBG1 in aging and cancer. ..
  30. Dowell J, Tsai S, Dias Santagata D, Nakajima H, Wang Z, Zhu W, et al. Expression of a mutant p193/CUL7 molecule confers resistance to MG132- and etoposide-induced apoptosis independent of p53 or Parc binding. Biochim Biophys Acta. 2007;1773:358-66 pubmed
    p193/CUL7 is an E3 ubiquitin ligase initially identified as an SV40 Large T Antigen binding protein...
  31. Men X, Wang L, Yu W, Ju Y. Cullin7 is required for lung cancer cell proliferation and is overexpressed in lung cancer. Oncol Res. 2015;22:123-8 pubmed publisher
    ..Thus, our study provided evidence that Cullin7 functions as a novel oncogene in lung cancer and may be a potential therapeutic target for lung cancer management. ..
  32. Meazza C, Lausch E, Pagani S, Bozzola E, Calcaterra V, Superti Furga A, et al. 3-M syndrome associated with growth hormone deficiency: 18 year follow-up of a patient. Ital J Pediatr. 2013;39:21 pubmed publisher
    ..Mutations in the CUL7, OBSL1 and CCDC8 genes could be responsible for 3-M syndrome...
  33. Shafique S, Ali W, Kanwal S, Rashid S. Structural basis for Cullins and RING component inhibition: Targeting E3 ubiquitin pathway conductors for cancer therapeutics. Int J Biol Macromol. 2018;106:532-543 pubmed publisher
    ..assembly and interaction details of closely related CUL scaffolds (CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5 and CUL7) with RBX1 to screen potent small molecules against CRLs...
  34. Huber C, Munnich A, Cormier Daire V. The 3M syndrome. Best Pract Res Clin Endocrinol Metab. 2011;25:143-51 pubmed publisher
    ..There is no specific treatment. Up till now, mutations in either CUL7 or OBSL1 genes have been identified in this rare disorder...
  35. Kasper J, Arai T, DeCaprio J. A novel p53-binding domain in CUL7. Biochem Biophys Res Commun. 2006;348:132-8 pubmed
    b>CUL7 is a member of the cullin RING ligase family and forms an SCF-like complex with SKP1 and FBXW8...
  36. Xi J, Zeng S, Guo L, Feng J. High Expression of Cullin7 Correlates with Unfavorable Prognosis in Epithelial Ovarian Cancer Patients. Cancer Invest. 2016;34:130-6 pubmed publisher
    ..033). Furthermore, Cullin7 overexpression inhibited the migration and invasion of ovarian cancer cells. These results suggest that Cullin7 may serve as an indicator of poor prognosis in patients with EOC. ..
  37. Hasegawa K, Tanaka H, Higuchi Y, Yamashita M, Tsukahara H. Changes in facial appearance from neonate to adult in 3-M syndrome patient with novel CUL7 gene mutations. J Pediatr Endocrinol Metab. 2016;29:241-6 pubmed publisher
    ..Three genes, cullin 7 (CUL7), coiled-coil domain containing 8, and obscurin-like 1 are genetic candidates of 3-M syndrome...
  38. Kim S, Shago M, Kaustov L, Boutros P, Clendening J, Sheng Y, et al. CUL7 is a novel antiapoptotic oncogene. Cancer Res. 2007;67:9616-22 pubmed
    Using an expression cloning approach, we identify CUL7, a member of the cullin family, as a functional inhibitor of Myc-induced apoptosis...
  39. Zhang D, Yang G, Li X, Xu C, Ge H. Inhibition of Liver Carcinoma Cell Invasion and Metastasis by Knockdown of Cullin7 In Vitro and In Vivo. Oncol Res. 2016;23:171-81 pubmed publisher
    ..The results of this study helped to elucidate the oncogene functions of Cullin7 in liver cancers. ..
  40. Lugli L, Bertucci E, Mazza V, Elmakky A, Ferrari F, Neuhaus C, et al. Pre- and post-natal growth in two sisters with 3-M syndrome. Eur J Med Genet. 2016;59:232-6 pubmed publisher
    ..3-M syndrome and we describe the prenatal and postnatal growth pattern of two affected sisters with a novel homozygous CUL7 mutation (c.3173-1G>C), showing a pre- and post-natal growth deficiency and a normal cranial circumference.
  41. Latini P, Frontini M, Caputo M, Gregan J, Cipak L, Filippi S, et al. CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination. Cell Cycle. 2011;10:3719-30 pubmed publisher
    ..The deregulation of p53, in absence of either of the CS proteins, can potentially explain the early onset degeneration of tissues and organs observed in CS patients. ..
  42. Guo H, Wu F, Wang Y, Yan C, Su W. Overexpressed ubiquitin ligase Cullin7 in breast cancer promotes cell proliferation and invasion via down-regulating p53. Biochem Biophys Res Commun. 2014;450:1370-6 pubmed publisher
    ..Thus, our study provided evidence that Cullin7 functions as a novel oncogene in breast cancer and may be a potential therapeutic target for breast cancer management. ..
  43. Wang H, Chen Y, Lin P, Li L, Zhou G, Liu G, et al. The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1. J Biol Chem. 2014;289:4009-17 pubmed publisher
    ..We found that the CUL7/Fbxw8 ubiquitin ligase targeted HPK1 for degradation via the 26 S proteasome...
  44. Hu X, Li H, Gui B, Xu Y, Wang J, Li N, et al. Prenatal and early diagnosis of Chinese 3-M syndrome patients with novel pathogenic variants. Clin Chim Acta. 2017;474:159-164 pubmed publisher
    ..Molecular testing for CUL7, OBSL1 or CCDC8 genes can provide confirmed diagnosis for patients at prenatal or early age...
  45. Xu X, Keshwani M, Meyer K, Sarikas A, Taylor S, Pan Z. Identification of the degradation determinants of insulin receptor substrate 1 for signaling cullin-RING E3 ubiquitin ligase 7-mediated ubiquitination. J Biol Chem. 2012;287:40758-66 pubmed publisher
    ..The requirement of multisite phosphorylation and the N terminus of IRS1 for its turnover may ensure that complete IRS1 degradation occurs only when mTORC1 and S6K1 reach exceedingly high levels. ..
  46. Fahlbusch F, Dawood Y, Hartner A, Menendez Castro C, Nögel S, Tzschoppe A, et al. Cullin 7 and Fbxw 8 expression in trophoblastic cells is regulated via oxygen tension: implications for intrauterine growth restriction?. J Matern Fetal Neonatal Med. 2012;25:2209-15 pubmed publisher
    The F-box protein Fbxw8 is a cofactor of Cullin 7 (Cul7), which regulates protein transfer to the proteasome and cell growth...
  47. Hartmann T, Xu X, Kronast M, Muehlich S, Meyer K, Zimmermann W, et al. Inhibition of Cullin-RING E3 ubiquitin ligase 7 by simian virus 40 large T antigen. Proc Natl Acad Sci U S A. 2014;111:3371-6 pubmed publisher
    ..In addition, SV40 transformation requires binding of LT to Cullin 7 (CUL7), a core component of Cullin-RING E3 ubiquitin ligase 7 (CRL7)...
  48. Ponyeam W, Hagen T. Characterization of the Cullin7 E3 ubiquitin ligase--heterodimerization of cullin substrate receptors as a novel mechanism to regulate cullin E3 ligase activity. Cell Signal. 2012;24:290-5 pubmed publisher
    Cul1 and Cul7 are cullin E3 ubiquitin ligase scaffold proteins. Cul1 is known to form a complex with the RING domain protein Rbx1 and one of approximately 70 different F-box proteins...
  49. Coffill C, Muller P, Oh H, Neo S, Hogue K, Cheok C, et al. Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. EMBO Rep. 2012;13:638-44 pubmed publisher
    ..Advanced proteomics has thus allowed the detection of a new mechanism of p53-driven invasion. ..
  50. Kong C, Samovski D, Srikanth P, Wainszelbaum M, Charron A, Liu J, et al. Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is mediated by CUL7 E3 ligase. PLoS ONE. 2012;7:e46485 pubmed publisher
    ..Using a yeast two-hybrid screen, we identified CUL7, the scaffolding subunit of the CUL7 E3 ligase complex, as a TBC1D3-interacting protein...