CUL4B

Summary

Gene Symbol: CUL4B
Description: cullin 4B
Alias: CUL-4B, MRXHF2, MRXS15, MRXSC, SFM2, cullin-4B
Species: human
Products:     CUL4B

Top Publications

  1. Li T, Santockyte R, Shen R, Tekle E, Wang G, Yang D, et al. A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. Arch Biochem Biophys. 2006;453:70-4 pubmed
    ..Most of the E1-like activating enzymes, E2-like conjugating enzymes and the majorities of the known target as well as some previously unreported proteins for SUMO-2, SUMO-3, and NEDD8 pathways were identified. ..
  2. Higa L, Yang X, Zheng J, Banks D, Wu M, Ghosh P, et al. Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation. Cell Cycle. 2006;5:71-7 pubmed
    ..We provide evidence that human CUL4B, a paralogue of human CUL4A, is involved in cyclin E regulation...
  3. Abbas T, Shibata E, Park J, Jha S, Karnani N, Dutta A. CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation. Mol Cell. 2010;40:9-21 pubmed publisher
    ..These results demonstrate a central role of CRL4(Cdt2)-dependent cell-cycle regulation of Set8 for the maintenance of a stable epigenetic state essential for cell viability. ..
  4. Nakagawa T, Xiong Y. X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression. Mol Cell. 2011;43:381-91 pubmed publisher
    b>CUL4B, encoding a scaffold protein for the assembly of Cullin4B-Ring ubiquitin ligase (CRL4B) complexes, is frequently mutated in X-linked mental retardation (XLMR) patients...
  5. Higa L, Mihaylov I, Banks D, Zheng J, Zhang H. Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint. Nat Cell Biol. 2003;5:1008-15 pubmed
    ..Our study reveals an evolutionarily conserved and uncharacterized G1 checkpoint that induces CDT1 proteolysis by the CUL4-ROC1 ubiquitin E3 ligase and CSN complexes in response to DNA damage. ..
  6. Ohtake F, Baba A, Takada I, Okada M, Iwasaki K, Miki H, et al. Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature. 2007;446:562-6 pubmed
    ..ligase complex in human cell lines, in which dioxin receptor (AhR) is integrated as a component of a novel cullin 4B ubiquitin ligase complex, CUL4B(AhR)...
  7. Guerrero Santoro J, Kapetanaki M, Hsieh C, Gorbachinsky I, Levine A, Rapic Otrin V. The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A. Cancer Res. 2008;68:5014-22 pubmed publisher
    ..Mutations in DDB2 cause a cancer prone syndrome, xeroderma pigmentosum group E (XP-E). CUL4A and its paralog, cullin 4B (CUL4B), copurify with the UV-DDB complex, but it is unclear whether CUL4B has a role in NER as a separate E3 ..
  8. Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A. PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev. 2008;22:2496-506 pubmed publisher
    ..Finally, we show that the CRL4(Cdt2) and the SCF(Skp2) ubiquitin ligases are redundant with each other in promoting the degradation of p21 during an unperturbed S phase of the cell cycle. ..
  9. Zou Y, Mi J, Cui J, Lu D, Zhang X, Guo C, et al. Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression. J Biol Chem. 2009;284:33320-32 pubmed publisher
    CUL4A and CUL4B, which are derived from the same ancestor, CUL4, encode scaffold proteins that organize cullin-RING ubiquitin ligase (E3) complexes...

More Information

Publications132 found, 100 shown here

  1. Liu H, Enikolopov G, Chen Y. Cul4B regulates neural progenitor cell growth. BMC Neurosci. 2012;13:112 pubmed publisher
    ..Genetic mutations of cullin-4b (cul4b) cause a prevalent type of X-linked intellectual disability (XLID) in males, but the physiological function of ..
  2. Senga T, Sivaprasad U, Zhu W, Park J, Arias E, Walter J, et al. PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination. J Biol Chem. 2006;281:6246-52 pubmed
    ..Therefore PCNA, the matchmaker for many proteins involved in DNA and chromatin metabolism, also serves to promote the targeted degradation of associated proteins in S-phase or after DNA damage. ..
  3. Banks D, Wu M, Higa L, Gavrilova N, Quan J, Ye T, et al. L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes. Cell Cycle. 2006;5:1719-29 pubmed
    ..Our studies demonstrate that PCNA, L2DTL and the DDB1-CUL4A complex play critical and differential roles in regulating the protein stability of p53 and MDM2/HDM2 in unstressed and stressed cells. ..
  4. Tarpey P, Raymond F, O Meara S, Edkins S, Teague J, Butler A, et al. Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor. Am J Hum Genet. 2007;80:345-52 pubmed
    We have identified three truncating, two splice-site, and three missense variants at conserved amino acids in the CUL4B gene on Xq24 in 8 of 250 families with X-linked mental retardation (XLMR)...
  5. Zou Y, Liu Q, Chen B, Zhang X, Guo C, Zhou H, et al. Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation. Am J Hum Genet. 2007;80:561-6 pubmed
    ..Screening of candidate genes in a 10-Mb region on Xq25 implicated CUL4B as the causative gene...
  6. Jackson S, Xiong Y. CRL4s: the CUL4-RING E3 ubiquitin ligases. Trends Biochem Sci. 2009;34:562-70 pubmed publisher
    ..Many CRL4 complexes are involved in chromatin regulation and are frequently hijacked by different viruses. ..
  7. Kerzendorfer C, Whibley A, Carpenter G, Outwin E, Chiang S, Turner G, et al. Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks. Hum Mol Genet. 2010;19:1324-34 pubmed publisher
    ..But, the functional distinction between CUL4A and CUL4B, if any, is unclear...
  8. Li X, Lu D, He F, Zhou H, Liu Q, Wang Y, et al. Cullin 4B protein ubiquitin ligase targets peroxiredoxin III for degradation. J Biol Chem. 2011;286:32344-54 pubmed publisher
    b>Cullin 4B (CUL4B) is a scaffold protein that assembles cullin-RING ubiquitin ligase (E3) complexes...
  9. Hori T, Osaka F, Chiba T, Miyamoto C, Okabayashi K, Shimbara N, et al. Covalent modification of all members of human cullin family proteins by NEDD8. Oncogene. 1999;18:6829-34 pubmed
    ..The enhanced expression of all Cul-family proteins except Cul-5 was observed in a variety of tumor cell lines. ..
  10. Wang H, Zhai L, Xu J, Joo H, Jackson S, Erdjument Bromage H, et al. Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Mol Cell. 2006;22:383-94 pubmed
    ..Thus, our studies uncover CUL4-DDB-ROC1 as a histone ubiquitin ligase and demonstrate that histone H3 and H4 ubiquitylation participates in the cellular response to DNA damage. ..
  11. Aggarwal P, Vaites L, Kim J, Mellert H, Gurung B, Nakagawa H, et al. Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer Cell. 2010;18:329-40 pubmed publisher
    ..Importantly, human cancers harboring mutations in Fbx4, the cyclin D1 E3 ligase, exhibit nuclear cyclin D1 accumulation and increased PRMT5 activity. ..
  12. Larance M, Kirkwood K, Xirodimas D, Lundberg E, Uhlen M, Lamond A. Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway. Mol Cell Proteomics. 2012;11:M111.014407 pubmed publisher
    ..MRFAP1 bound to a number of E3 ubiquitin ligases, including CUL4B, but not to components of the NuA4 complex, including MRGBP, which bound to MORF4L1...
  13. Li Q, Cui M, Yang F, Li N, Jiang B, Yu Z, et al. A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. J Clin Invest. 2017;127:2631-2646 pubmed publisher
    ..Here, we found that a super-complex comprising the cullin 4B-RING E3 ligase (CRL4B) and polycomb repressive complex 2 (PRC2) epigenetically regulates somatostatin secretion ..
  14. Shen E, Shulha H, Weng Z, Akbarian S. Regulation of histone H3K4 methylation in brain development and disease. Philos Trans R Soc Lond B Biol Sci. 2014;369: pubmed publisher
    ..list of mutations implicated in monogenic disorders of the developing brain includes at least seven genes (ARX, CUL4B, KDM5A, KDM5C, KMT2A, KMT2C, KMT2D) with loss-of-function mutations affecting proper regulation of histone H3 ..
  15. Zhang D, Lo S, Cross J, Templeton D, Hannink M. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol. 2004;24:10941-53 pubmed
  16. Chen C, Tsai M, Lin C, Yu I, Chen Y, Lin S, et al. Rescue of the genetically engineered Cul4b mutant mouse as a potential model for human X-linked mental retardation. Hum Mol Genet. 2012;21:4270-85 pubmed publisher
    Mutation in CUL4B, which encodes a scaffold protein of the E3 ubiquitin ligase complex, has been found in patients with X-linked mental retardation (XLMR)...
  17. Pfeiffer J, Brooks S. Cullin 4B is recruited to tristetraprolin-containing messenger ribonucleoproteins and regulates TNF-α mRNA polysome loading. J Immunol. 2012;188:1828-39 pubmed publisher
    ..Using a screen to identify TTP-interacting proteins, we identified Cullin 4B (Cul4B), a scaffolding component of the Cullin ring finger ligase family of ubiquitin E3 ligases...
  18. Liu L, Yin Y, Li Y, Prevedel L, LACY E, Ma L, et al. Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis. Cell Res. 2012;22:1258-69 pubmed publisher
    Mutations of the CUL4B ubiquitin ligase gene are causally linked to syndromic X-linked mental retardation (XLMR). However, the pathogenic role of CUL4B mutations in neuronal and developmental defects is not understood...
  19. Jiang B, Zhao W, Yuan J, Qian Y, Sun W, Zou Y, et al. Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development. PLoS ONE. 2012;7:e37070 pubmed publisher
    ..Mutations in human CUL4B, one of the eight members in cullin family, are one of the major causes of X-linked mental retardation...
  20. Meng D, Yang S, Wan X, Zhang Y, Huang W, Zhao P, et al. A transcriptional target of androgen receptor, miR-421 regulates proliferation and metabolism of prostate cancer cells. Int J Biochem Cell Biol. 2016;73:30-40 pubmed publisher
    ..According to the result of miR-421 target genes searching, we focused on 4 genes NRAS, PRAME, CUL4B and PFKFB2 based on their involvement in cell proliferation, cell cycle progression and metabolism...
  21. Qian Y, Yuan J, Hu H, Yang Q, Li J, Zhang S, et al. The CUL4B/AKT/β-Catenin Axis Restricts the Accumulation of Myeloid-Derived Suppressor Cells to Prohibit the Establishment of a Tumor-Permissive Microenvironment. Cancer Res. 2015;75:5070-83 pubmed publisher
    ..b>Cullin 4B (CUL4B), a scaffold protein in the Cullin 4B-RING E3 ligase complex (CRL4B), represses tumor suppressors through ..
  22. Qi M, Hu J, Cui Y, Jiao M, Feng T, Li X, et al. CUL4B promotes prostate cancer progression by forming positive feedback loop with SOX4. Oncogenesis. 2019;8:23 pubmed publisher
    ..How to distinguish indolent from aggressive disease remains a great challenge in prostate cancer (PCa) management. Cullin 4B (CUL4B) is a scaffold protein and exhibits oncogenic activity in a variety of human malignancies...
  23. Li Q, Shah P, Li Y, Aiyetan P, Chen J, Yung R, et al. Glycoproteomic analysis of bronchoalveolar lavage (BAL) fluid identifies tumor-associated glycoproteins from lung adenocarcinoma. J Proteome Res. 2013;12:3689-96 pubmed publisher
    ..The levels of Napsin A in cancer BAL were further verified in independently collected 39 BAL specimens using an ELISA assay. Our study demonstrates that potential protein biomarkers in BAL fluid can be detected and quantified. ..
  24. Xiao F, Kim Y, Snyder C, Wen H, Chen P, Luo J, et al. Genome instability in blood cells of a BRCA1+ breast cancer family. BMC Cancer. 2014;14:342 pubmed publisher
    ..important and breast cancer-related genes, including transcriptional factor BPTF and FOXP1, ubiquitin ligase CUL4B, phosphorylase kinase PHKG2, and nuclear receptor activator SRA1...
  25. Kim A, Bommelje C, Lee B, Yonekawa Y, Choi L, Morris L, et al. SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation. J Biol Chem. 2008;283:33211-20 pubmed publisher
  26. Kopanja D, Roy N, Stoyanova T, Hess R, Bagchi S, Raychaudhuri P. Cul4A is essential for spermatogenesis and male fertility. Dev Biol. 2011;352:278-87 pubmed publisher
    The mammalian Cul4 genes, Cul4A and Cul4B, encode the scaffold components of the cullin-based E3 ubiquitin ligases. The two Cul4 genes are functionally redundant...
  27. Chen Z, Shen B, Fu Q, Wang F, Tang Y, Hou C, et al. CUL4B promotes proliferation and inhibits apoptosis of human osteosarcoma cells. Oncol Rep. 2014;32:2047-53 pubmed publisher
    b>Cullin 4B (CUL4B) is a component of the Cullin4B-Ring E3 ligase complex (CRL4B) that functions in proteolysis and is implicated in tumorigenesis...
  28. Zhao Y, Sun Y. CUL4B ubiquitin ligase in mouse development: a model for human X-linked mental retardation syndrome?. Cell Res. 2012;22:1224-6 pubmed publisher
    b>CUL4B, a member of the cullin-RING ubiquitin ligase family, is frequently mutated in X-linked mental retardation (XLMR) patients. The study by Liu et al...
  29. Chen G, Zhou H. MiRNA-708/CUL4B axis contributes into cell proliferation and apoptosis of osteosarcoma. Eur Rev Med Pharmacol Sci. 2018;22:5452-5459 pubmed publisher
    ..Detection of the expression of miRNA-708 and CUL4B was used by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR)...
  30. Gracheva E, Chitale S, Wilhelm T, Rapp A, Byrne J, Stadler J, et al. ZRF1 mediates remodeling of E3 ligases at DNA lesion sites during nucleotide excision repair. J Cell Biol. 2016;213:185-200 pubmed publisher
    ..of histone H2A (H2A-ubiquitin) is catalyzed predominantly by a novel E3 ligase complex consisting of DDB2, DDB1, CUL4B, and RING1B (UV-RING1B complex) that acts early during lesion recognition...
  31. Chen Z, Wang K, Hou C, Jiang K, Chen B, Chen J, et al. CRL4BDCAF11 E3 ligase targets p21 for degradation to control cell cycle progression in human osteosarcoma cells. Sci Rep. 2017;7:1175 pubmed publisher
    ..Our previous work revealed that Cullin 4B (CUL4B), a critical component of the Cullin4B-RING E3 ligase complex (CRL4B), is overexpressed in human ..
  32. Fei J, Chen J. KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR). J Biol Chem. 2012;287:35118-26 pubmed publisher
    ..Together, our data not only reveal that KIAA1530 is an important player in TCR but also lead to a better understanding of the molecular mechanism underlying UV(s)S syndrome. ..
  33. Wang H, Chang N, Weng Y, Yeh T. XLID CUL4B mutants are defective in promoting TSC2 degradation and positively regulating mTOR signaling in neocortical neurons. Biochim Biophys Acta. 2013;1832:585-93 pubmed publisher
    Truncating or missense mutation of cullin 4B (CUL4B) is one of the most prevalent causes underlying X-linked intellectual disability (XLID). CUL4B-RING E3 ubiquitin ligase promotes ubiquitination and degradation of various proteins...
  34. Yoshimura S, Kumeta M, Takeyasu K. Structural mechanism of nuclear transport mediated by importin β and flexible amphiphilic proteins. Structure. 2014;22:1699-710 pubmed
    ..These results show that conformational changes in the flexible amphiphilic motifs play a critical role in translocation through the NPC. ..
  35. Chen P, Yao G. The role of cullin proteins in gastric cancer. Tumour Biol. 2016;37:29-37 pubmed publisher
    ..There are seven cullin proteins that have been identified in eukaryotes: CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, and CUL7/p53-associated parkin-like cytoplasmic protein...
  36. Mao X, Xiao J, Xu G, Li Z, Wu H, Li Y, et al. CUL4B promotes bladder cancer metastasis and induces epithelial-to-mesenchymal transition by activating the Wnt/?-catenin signaling pathway. Oncotarget. 2017;8:77241-77253 pubmed publisher
    Increased expression of cullin 4B (CUL4B) is linked to progression in several cancers...
  37. Qu Z, Li D, Xu H, Zhang R, Li B, Sun C, et al.  CUL4B, NEDD4, and UGT1As involve in the TGF-? signalling in hepatocellular carcinoma. Ann Hepatol. 2016;15:568-76 pubmed
    ..The DEGs were significantly enriched in adhesion-related functions. PPI network indicted hub genes such as CUL4B and NEDD4. According to the TF-DEG regulatory network, the two hub genes were targeted by SMAD2, SMAD3, and HNF4A...
  38. Del Prete D, Rice R, Rajadhyaksha A, D ADAMIO L. Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration. J Biol Chem. 2016;291:17209-27 pubmed publisher
    ..namely Tau and apoE, interact with and are ubiquitinated via the ACR in vitro This, and the evidence that CRBN and CUL4B are linked to intellectual disability, prompts us to hypothesize a pathogenic mechanism, in which APP acts as a ..
  39. Dong J, Wang X, Yao J, Li G, Li X. Decreased CUL4B expression inhibits malignant proliferation of glioma in vitro and in vivo. Eur Rev Med Pharmacol Sci. 2015;19:1013-21 pubmed
    b>Cullin 4B (CUL4B) is a component of the Cullin 4B-Ring E3 ligase complex (CRL4B) that plays a role in proteolysis and is implicated in tumorigenesis. However, little is known about CUL4B function in human brain tumors, including glioma...
  40. Qi M, Jiao M, Li X, Hu J, Wang L, Zou Y, et al. CUL4B promotes gastric cancer invasion and metastasis-involvement of upregulation of HER2. Oncogene. 2017;: pubmed publisher
    b>Cullin 4B (CUL4B) is a scaffold protein overexpressed in several solid malignancies. It is known to silence tumor suppressor through post-transcriptional manner...
  41. Sung C, Dahl J, Yim H, Rodig S, Benjamin T. Transcriptional and post-translational regulation of the quiescence factor and putative tumor suppressor p150(Sal2). FASEB J. 2011;25:1275-83 pubmed publisher
    ..A CUL4/DDB1 E3 ligase containing RBBP7 as the p150(Sal2) receptor has been identified as mediating the destruction of p150(Sal2) as cells transition from a quiescent to an actively growing state. ..
  42. Zhang H, Li S, Liu P, Lee F, Wong A, Liu F. Proteomic analysis of the cullin 4B interactome using proximity-dependent biotinylation in living cells. Proteomics. 2017;17: pubmed publisher
    b>Cullin 4B (CUL4B) mutations have been implicated in mental retardation and dopamine-related behaviors due to disruptions in their interaction with cullin-RING E3 ligases (CRLs)...
  43. Jin Z, Yu L, Geng J, Wang J, Jin X, Huang H. A novel 47.2 Mb duplication on chromosomal bands Xq21.1-25 associated with mental retardation. Gene. 2015;567:98-102 pubmed publisher
    ..Ten genes (i.e., ZNF711, SRPX2, RAB40AL, MID2, ACSL4, PAK3, UBE2A, UPF3B, CUL4B, and GRIA3) in the duplication interval have been associated with mental retardation...
  44. Liu F, Cao L, Zhang T, Chang F, Xu Y, Li Q, et al. CRL4BRBBP7 targets HUWE1 for ubiquitination and proteasomal degradation. Biochem Biophys Res Commun. 2018;501:440-447 pubmed publisher
    ..Our previous study has shown that in response to DNA damage HUWE1 was downregulated in CUL4B-mediated ubiquitination and subsequent proteasomal degradation, and CUL4B-mediated regulation of HUWE1 was ..
  45. Thirunavukarasou A, Govindarajalu G, Singh P, Bandi V, Muthu K, Baluchamy S. Cullin 4A and 4B ubiquitin ligases interact with γ-tubulin and induce its polyubiquitination. Mol Cell Biochem. 2015;401:219-28 pubmed publisher
    ..co-immunoprecipitation studies using endogenous CUL4A/B and stable cell lines that overexpress Flag-CUL4A or Flag-CUL4B. We additionally noted that the γ-tubulin was polyubiquitinated by CUL4A or 4B immune complex indicating that ..
  46. Fan W, Fan Z, Yang M, Pan Y, Bai H. [Molecular Mechanism of CRBN in the Activity of Lenalidomid eagainst Myeloma--Review]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018;26:1240-1243 pubmed publisher
    ..protein with ionic protease activity, which interacts with DNA damage-binding protein-1 (DDB1), Cullin 4 (Cul4A or Cul4B), and regulator of Cullins 1 (RoC1) to form the functional E3 ubiquitin ligase complex(CRBN-CRL4) that performs ..
  47. Meyer Schaller N, Chou Y, Sumara I, Martin D, Kurz T, Katheder N, et al. The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes. Proc Natl Acad Sci U S A. 2009;106:12365-70 pubmed publisher
    ..Moreover, the diversification of the N termini in mammalian Dcn1 homologues may contribute to substrate specificity by regulating their subcellular localization. ..
  48. Zhao X, Jiang B, Hu H, Mao F, Mi J, Li Z, et al. Zebrafish cul4a, but not cul4b, modulates cardiac and forelimb development by upregulating tbx5a expression. Hum Mol Genet. 2015;24:853-64 pubmed publisher
    CUL4A and CUL4B are closely related cullin family members and can each assemble a Cullin-RING E3 ligase complex (CRL) and participate in a variety of biological processes...
  49. Zheng J, Yang X, Harrell J, Ryzhikov S, Shim E, Lykke Andersen K, et al. CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex. Mol Cell. 2002;10:1519-26 pubmed
    ..Our data suggest that CAND1 regulates the formation of the SCF complex, and its dissociation from CUL1 is coupled with the incorporation of F box proteins into the SCF complex, causing their destabilization. ..
  50. Min K, Hwang J, Lee J, Park Y, Tamura T, Yoon J. TIP120A associates with cullins and modulates ubiquitin ligase activity. J Biol Chem. 2003;278:15905-10 pubmed
    ..In a search for proteins involved in regulation of cullin-containing E3 ubiquitin ligases we immunopurified CUL4B-containing complex from HeLa cells and identified TIP120A as an associated protein by mass spectrometry...
  51. Yuan J, Han B, Hu H, Qian Y, Liu Z, Wei Z, et al. CUL4B activates Wnt/β-catenin signalling in hepatocellular carcinoma by repressing Wnt antagonists. J Pathol. 2015;235:784-95 pubmed publisher
    ..We recently reported that cullin 4B (CUL4B), a scaffold protein that assembles CRL4B ubiquitin ligase complexes, is overexpressed in many types of ..
  52. Yuan J, Jiang B, Zhang A, Qian Y, Tan H, Gao J, et al. Accelerated hepatocellular carcinoma development in CUL4B transgenic mice. Oncotarget. 2015;6:15209-21 pubmed
    b>Cullin 4B (CUL4B) is a component of the Cullin 4B-Ring E3 ligase (CRL4B) complex that functions in proteolysis and in epigenetic regulation...
  53. Lin C, Chen C, Yu C, Yu I, Lin S, Wu J, et al. Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep. 2016;6:20227 pubmed publisher
    In this study, we demonstrate that an E3-ubiquitin ligase associated with human X-linked intellectual disability, CUL4B, plays a crucial role in post-meiotic sperm development...
  54. Yin Y, Liu L, Yang C, Lin C, Veith G, Wang C, et al. Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis. J Biol Chem. 2016;291:6923-35 pubmed publisher
    b>CUL4B ubiquitin ligase belongs to the cullin-RING ubiquitin ligase family. Although sharing many sequence and structural similarities, CUL4B plays distinct roles in spermatogenesis from its homologous protein CUL4A...
  55. Su W, Liu Z. MiR-431 inhibits colorectal cancer cell invasion via repressing CUL4B. Eur Rev Med Pharmacol Sci. 2018;22:3047-3052 pubmed publisher
    ..The expression levels of cullin-4B (CUL4B) and EMT-related protein were evaluated by Western blotting assay...
  56. Mouysset J, Gilberto S, Meier M, Lampert F, Belwal M, Meraldi P, et al. CRL4(RBBP7) is required for efficient CENP-A deposition at centromeres. J Cell Sci. 2015;128:1732-45 pubmed publisher
    ..Our data thus suggest that the CRL4 complex containing RBBP7 (CRL4(RBBP7)) might regulate mitosis by promoting ubiquitin-dependent loading of newly synthesized CENP-A during the G1 phase of the cell cycle. ..
  57. Kamburov A, Lawrence M, Polak P, Leshchiner I, Lage K, Golub T, et al. Comprehensive assessment of cancer missense mutation clustering in protein structures. Proc Natl Acad Sci U S A. 2015;112:E5486-95 pubmed publisher
    ..of interaction interfaces revealed enrichment of mutations in the interfaces between FBXW7-CCNE1, HRAS-RASA1, CUL4B-CAND1, OGT-HCFC1, PPP2R1A-PPP2R5C/PPP2R2A, DICER1-Mg2+, MAX-DNA, SRSF2-RNA, and others...
  58. Miao C, Chang J, Zhang G, Yu H, Zhou L, Zhou G, et al. CUL4B promotes the pathology of adjuvant-induced arthritis in rats through the canonical Wnt signaling. J Mol Med (Berl). 2018;96:495-511 pubmed publisher
    This work aims to discuss the possibility that disordered CUL4B was involved in the pathogenesis of adjuvant-induced arthritis (AIA) in rats...
  59. Liu R, Gao J, Yang Y, Qiu R, Zheng Y, Huang W, et al. PHD finger protein 1 (PHF1) is a novel reader for histone H4R3 symmetric dimethylation and coordinates with PRMT5-WDR77/CRL4B complex to promote tumorigenesis. Nucleic Acids Res. 2018;46:6608-6626 pubmed publisher
    ..finger of PHF1, instead of binding to modified histones, directly interacts with DDB1, the main component of the CUL4B-Ring E3 ligase complex (CRL4B), which is responsible for H2AK119 mono-ubiquitination (H2AK119ub1)...
  60. Shibata E, Dar A, Dutta A. CRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phase. J Biol Chem. 2014;289:23056-64 pubmed publisher
    ..Thus, CRL4(Cdt2)-dependent degradation of TDG occurs in S phase because of the requirement for TDG to interact with chromatin-loaded PCNA, and this degradation is important for preventing toxicity from excess TDG. ..
  61. Song B, Zhan H, Bian Q, Li J. Knockdown of CUL4B inhibits proliferation and promotes apoptosis of colorectal cancer cells through suppressing the Wnt/β-catenin signaling pathway. Int J Clin Exp Pathol. 2015;8:10394-402 pubmed
    Colorectal cancer is one of the leading causes of cancer related deaths worldwide. Cullin 4B (CUL4B) is over-expressed in diverse cancer types...
  62. Cochrane A, Murley L, Gao M, Wong R, Clayton K, Brufatto N, et al. Stable complex formation between HIV Rev and the nucleosome assembly protein, NAP1, affects Rev function. Virology. 2009;388:103-11 pubmed publisher
    ..The results suggest that Nap-1 may influence Rev function by increasing the availability of Rev. ..
  63. Morimoto A, Kannari M, Tsuchida Y, Sasaki S, Saito C, Matsuta T, et al. An HNF4?-microRNA-194/192 signaling axis maintains hepatic cell function. J Biol Chem. 2017;292:10574-10585 pubmed publisher
    ..and epiregulin (Ereg)), protein SUMOylation (Sumo2), epigenetic regulation (Setd5 and Cullin 4B (Cln4b)), and the epithelial-mesenchymal transition (moesin (Msn)) was up-regulated in Hnf4a..
  64. Miranda Carboni G, Krum S, Yee K, Nava M, Deng Q, Pervin S, et al. A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev. 2008;22:3121-34 pubmed publisher
    ..Instead, turnover required Cullin 4A and Cullin 4B, components of an alternative E3 ubiquitin ligase induced in response to active Wnt signaling...
  65. Ravn K, Lindquist S, Nielsen K, Dahm T, Tumer Z. Deletion of CUL4B leads to concordant phenotype in a monozygotic twin pair. Clin Genet. 2012;82:292-4 pubmed publisher
  66. Vulto van Silfhout A, Nakagawa T, Bahi Buisson N, Haas S, Hu H, Bienek M, et al. Variants in CUL4B are associated with cerebral malformations. Hum Mutat. 2015;36:106-17 pubmed publisher
    Variants in cullin 4B (CUL4B) are a known cause of syndromic X-linked intellectual disability. Here, we describe an additional 25 patients from 11 families with variants in CUL4B...
  67. Sjögren B, Swaney S, Neubig R. FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex. PLoS ONE. 2015;10:e0123581 pubmed publisher
    ..Using a genomic siRNA screening approach, we identified a novel E3 ligase complex containing cullin 4B (CUL4B), DNA damage binding protein 1 (DDB1) and F-box protein 44 (FBXO44) that mediates RGS2 protein ..
  68. Li P, Song Y, Zan W, Qin L, Han S, Jiang B, et al. Lack of CUL4B in Adipocytes Promotes PPARγ-Mediated Adipose Tissue Expansion and Insulin Sensitivity. Diabetes. 2017;66:300-313 pubmed publisher
    ..Here we report that CUL4B-RING E3 ligase (CRL4B) negatively regulates PPARγ by promoting its polyubiquitination and proteasomal degradation...
  69. Shafique S, Ali W, Kanwal S, Rashid S. Structural basis for Cullins and RING component inhibition: Targeting E3 ubiquitin pathway conductors for cancer therapeutics. Int J Biol Macromol. 2018;106:532-543 pubmed publisher
    ..the structural assembly and interaction details of closely related CUL scaffolds (CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5 and CUL7) with RBX1 to screen potent small molecules against CRLs...
  70. Ohta T, Michel J, Schottelius A, Xiong Y. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Mol Cell. 1999;3:535-41 pubmed
    ..Ubiquitination of phosphorylated I kappa B alpha can be catalyzed by the ROC1 immunocomplex in vitro. Hence, combinations of ROC/APC11 and cullin proteins proteins potentially constitute a wide variety of ubiquitin ligases. ..
  71. Shibata E, Abbas T, Huang X, Wohlschlegel J, Dutta A. Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex. Mol Cell Biol. 2011;31:3136-45 pubmed publisher
    ..These findings identify the UBCs required for the activity of CRL4(Cdt2) on multiple substrates and demonstrate that different UBCs are involved in the selective ubiquitylation of different substrates by the same E3 complex. ..
  72. Jiang T, Tang H, Wu Z, Chen J, Lu S, Zhou C, et al. Cullin 4B is a novel prognostic marker that correlates with colon cancer progression and pathogenesis. Med Oncol. 2013;30:534 pubmed publisher
    b>Cullin 4B (CUL4B), a scaffold protein of the Cullin4B-RING E3 ligase complex, functions in proteolysis...
  73. Ji Q, Hu H, Yang F, Yuan J, Yang Y, Jiang L, et al. CRL4B interacts with and coordinates the SIN3A-HDAC complex to repress CDKN1A and drive cell cycle progression. J Cell Sci. 2014;127:4679-91 pubmed publisher
    b>CUL4B, a scaffold protein that assembles the CRL4B ubiquitin ligase complex, participates in the regulation of a broad spectrum of biological processes. Here, we demonstrate a crucial role of CUL4B in driving cell cycle progression...
  74. Chen Z, Zhang W, Jiang K, Chen B, Wang K, Lao L, et al. MicroRNA-300 Regulates the Ubiquitination of PTEN through the CRL4BDCAF13 E3 Ligase in Osteosarcoma Cells. Mol Ther Nucleic Acids. 2018;10:254-268 pubmed publisher
    ..Here, we demonstrate that overexpressed CUL4B in human osteosarcoma cells forms an E3 complex with DNA damage binding protein 1 (DDB1) and DDB1- and CUL4-..
  75. Kawajiri K, Kobayashi Y, Ohtake F, Ikuta T, Matsushima Y, Mimura J, et al. Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands. Proc Natl Acad Sci U S A. 2009;106:13481-6 pubmed publisher
    ..These findings suggest that chemoprevention with naturally-occurring and chemically-designed AhR ligands can be used to successfully prevent intestinal cancers. ..
  76. Hu H, Yang Y, Ji Q, Zhao W, Jiang B, Liu R, et al. CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis. Cancer Cell. 2012;22:781-95 pubmed publisher
    ..Ablation of Cul4b or depletion of CUL4B, the main component of CRL4B, resulted in loss of not only H2AK119 monoubiquitination but ..
  77. Hannah J, Zhou P. Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B. Gene. 2015;573:33-45 pubmed publisher
    The cullin 4 subfamily of genes includes CUL4A and CUL4B, which share a mostly identical amino acid sequence aside from the elongated N-terminal region in CUL4B...
  78. Li J, Chen C, Ma X, Geng G, Liu B, Zhang Y, et al. Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation. Nat Commun. 2016;7:11730 pubmed publisher
    ..NRON directly links Tat to the ubiquitin/proteasome components including CUL4B and PSMD11, thus facilitating Tat degradation...
  79. Mo Y, Lin R, Liu P, Tan M, Xiong Y, Guan K, et al. SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes. FEBS J. 2017;284:3619-3636 pubmed publisher
    ..Our study uncovers a novel regulation of CRL4 E3 ligase complexes. ..
  80. Zhao W, Jiang B, Hu H, Zhang S, Lv S, Yuan J, et al. Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain. Hum Mol Genet. 2015;24:4686-97 pubmed publisher
    ..Here, we show that CUL4B, a scaffold protein that assembles E3 ubiquitin ligase, represses the expression of GFAP in neural progenitor ..
  81. Hussain S, Feldman A, Das C, Ziesmer S, Ansell S, Galardy P. Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4-mediated ubiquitination of raptor. Mol Cell Biol. 2013;33:1188-97 pubmed publisher
    ..These data establish UCH-L1 as a key regulator of the dichotomy between mTORC1 and mTORC2 signaling. ..
  82. Thirunavukarasou A, Singh P, Govindarajalu G, Bandi V, Baluchamy S. E3 ubiquitin ligase Cullin4B mediated polyubiquitination of p53 for its degradation. Mol Cell Biochem. 2014;390:93-100 pubmed publisher
    ..Cullin 4A (CUL4A) and Cullin 4B (CUL4B) are members of cullin family proteins that mediate ubiquitin dependent proteolysis...
  83. Yoshizawa T, Karim M, Sato Y, Senokuchi T, Miyata K, Fukuda T, et al. SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway. Cell Metab. 2014;19:712-21 pubmed publisher
    ..studies revealed that the DDB1-CUL4-associated factor 1 (DCAF1)/damage-specific DNA binding protein 1 (DDB1)/cullin 4B (CUL4B) E3 ubiquitin ligase complex interacted with TR4, leading to its degradation, while binding of SIRT7 to ..
  84. Keuss M, Thomas Y, Mcarthur R, Wood N, Knebel A, Kurz T. Characterization of the mammalian family of DCN-type NEDD8 E3 ligases. J Cell Sci. 2016;129:1441-54 pubmed publisher
    ..Thus, the specificity between DCNL-type NEDD8 E3 enzymes and their cullin substrates is only apparent in well-defined physiological contexts and related to their subcellular distribution and restricted expression. ..
  85. Webster E, Cho M, Alexander N, Desai S, Naidu S, Bekheirnia M, et al. De novo PHIP-predicted deleterious variants are associated with developmental delay, intellectual disability, obesity, and dysmorphic features. Cold Spring Harb Mol Case Stud. 2016;2:a001172 pubmed
    ..PHIP1 is one of the multiple substrate receptors of the proteolytic CUL4-DDB1 ubiquitin ligase complex. CUL4B deficiency has been associated with intellectual disability, central obesity, muscle wasting, and dysmorphic ..
  86. Jia L, Yan F, Cao W, Chen Z, Zheng H, Li H, et al. Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer. J Biol Chem. 2017;292:2966-2978 pubmed publisher
    ..CRL4 proteins, including CUL4A and CUL4B, are often highly accumulated in human malignancies...
  87. Zhang J, Chen S, Gu J, Zhu Y, Zhan Q, Cheng D, et al. MicroRNA-300 promotes apoptosis and inhibits proliferation, migration, invasion and epithelial-mesenchymal transition via the Wnt/?-catenin signaling pathway by targeting CUL4B in pancreatic cancer cells. J Cell Biochem. 2018;119:1027-1040 pubmed publisher
    The study aims to verify the hypothesis that up-regulation of microRNA-300 (miR-300) targeting CUL4B promotes apoptosis and suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of pancreatic cancer ..
  88. Gascoin Lachambre G, Buffat C, Rebourcet R, Chelbi S, Rigourd V, Mondon F, et al. Cullins in human intra-uterine growth restriction: expressional and epigenetic alterations. Placenta. 2010;31:151-7 pubmed publisher
    ..Our work hypothesis is that Cullins, particularly CUL4B and CUL7, are involved in placental diseases and especially in IUGR...
  89. den Besten W, Verma R, Kleiger G, Oania R, Deshaies R. NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway. Nat Struct Mol Biol. 2012;19:511-6, S1 pubmed publisher
    ..These results uncover an unexpected and conserved role for NEDD8 in linking CRL ubiquitin ligase function to the p97 pathway. ..
  90. Gastaldello S, Callegari S, Coppotelli G, Hildebrand S, Song M, Masucci M. Herpes virus deneddylases interrupt the cullin-RING ligase neddylation cycle by inhibiting the binding of CAND1. J Mol Cell Biol. 2012;4:242-51 pubmed publisher
    ..These findings illustrate a new strategy for viral modulation of CRL activity where the combined effects of cullin deneddylation and their targeting for proteasomal degradation drive stable inactivation of the ligases...
  91. Sertic S, Evolvi C, Tumini E, Plevani P, Muzi Falconi M, Rotondo G. Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival. PLoS ONE. 2013;8:e60000 pubmed publisher
    ..preventing activity, we identified a non-canonical Cullin-4(CDT2) complex, containing both CUL4A and CUL4B, associated to the COP9 signalosome, that controls a RAD18-dependent damage avoidance pathway essential during an ..
  92. Olma M, Roy M, Le Bihan T, Sumara I, Maerki S, Larsen B, et al. An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. J Cell Sci. 2009;122:1035-44 pubmed publisher
    ..Cells depleted of Dda1 spontaneously accumulated double-stranded DNA breaks in a similar way to Cul4A-, Cul4B- or Wdr23-depleted cells, indicating that Dda1 interacts physically and functionally with CRL4 complexes...