CTNND2

Summary

Gene Symbol: CTNND2
Description: catenin delta 2
Alias: GT24, NPRAP, catenin delta-2, T-cell delta-catenin, catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein), neurojungin
Species: human
Products:     CTNND2

Top Publications

  1. Levesque G, Yu G, Nishimura M, Zhang D, Levesque L, Yu H, et al. Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin. J Neurochem. 1999;72:999-1008 pubmed
    ..p0071, and a novel neuronal-specific armadillo protein--neural plakophilin-related armadillo protein (NPRAP)...
  2. Ide N, Hata Y, Deguchi M, Hirao K, Yao I, Takai Y. Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin. Biochem Biophys Res Commun. 1999;256:456-61 pubmed
    ..we searched for S-SCAM-interacting proteins and obtained a neuralplakophilin-related armadillo-repeat protein (NPRAP)/delta-catenin...
  3. Tanahashi H, Tabira T. Isolation of human delta-catenin and its binding specificity with presenilin 1. Neuroreport. 1999;10:563-8 pubmed
    ..These results suggest that PS1 and PS2 partly differ in function. PS1 loop fragment containing the pathogenic mutation retained the binding ability. We also found another armadillo-protein, p0071, interacted with PS1. ..
  4. Zhou J, Liyanage U, Medina M, Ho C, Simmons A, Lovett M, et al. Presenilin 1 interaction in the brain with a novel member of the Armadillo family. Neuroreport. 1997;8:2085-90 pubmed
    ..Wg and Notch interactions are mediated by the Dishevelled gene, which may form a signaling complex with PS1 and Wg pathway intermediates to regulate the function of the Notch/lin-12 gene. ..
  5. Lu Q, Dobbs L, Gregory C, Lanford G, Revelo M, Shappell S, et al. Increased expression of delta-catenin/neural plakophilin-related armadillo protein is associated with the down-regulation and redistribution of E-cadherin and p120ctn in human prostate cancer. Hum Pathol. 2005;36:1037-48 pubmed
  6. Laura R, Witt A, Held H, Gerstner R, Deshayes K, Koehler M, et al. The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF. J Biol Chem. 2002;277:12906-14 pubmed
    ..They also demonstrate that C-terminal phage-display technology can be used to predict physiologically relevant ligands for PDZ domains. ..
  7. Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, et al. PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071. J Biol Chem. 2000;275:29875-80 pubmed
    A neural plakophilin-related armadillo repeat protein (NPRAP)/delta-catenin interacts with one of Alzheimer disease-related gene products, presenilin 1...
  8. Paffenholz R, Kuhn C, Grund C, Stehr S, Franke W. The arm-repeat protein NPRAP (neurojungin) is a constituent of the plaques of the outer limiting zone in the retina, defining a novel type of adhering junction. Exp Cell Res. 1999;250:452-64 pubmed
    ..have identified, by immunolocalization techniques, a recently discovered neural tissue-specific protein, neurojungin, a member of the plakoglobin/armadillo protein family...
  9. Lu Q, Paredes M, Medina M, Zhou J, Cavallo R, Peifer M, et al. delta-catenin, an adhesive junction-associated protein which promotes cell scattering. J Cell Biol. 1999;144:519-32 pubmed
    ..We propose that delta-catenin can regulate adhesion molecules to implement the organization of large cellular arrays necessary for tissue morphogenesis. ..

More Information

Publications64

  1. Paffenholz R, Franke W. Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family. Differentiation. 1997;61:293-304 pubmed
    ..expressed in neural and neuroendocrine tissues, hence the name neural plakophilin-related arm-repeat protein (NPRAP). The murine cDNA codes for a protein of 1247 aa, with a predicted molecular weight of 135 kDa and a pI of 7.57...
  2. Vrijenhoek T, Buizer Voskamp J, van der Stelt I, Strengman E, Sabatti C, Geurts van Kessel A, et al. Recurrent CNVs disrupt three candidate genes in schizophrenia patients. Am J Hum Genet. 2008;83:504-10 pubmed publisher
    ..Among the genes disrupted by the remaining rare CNVs are MYT1L, CTNND2, NRXN1, and ASTN2, genes that play an important role in neuronal functioning but--except for NRXN1--have not been ..
  3. Medina M, Marinescu R, Overhauser J, Kosik K. Hemizygosity of delta-catenin (CTNND2) is associated with severe mental retardation in cri-du-chat syndrome. Genomics. 2000;63:157-64 pubmed
    ..The genomic structure of the human delta-catenin gene (Human Gene Nomenclature Committee-approved symbol CTNND2) was determined and mapped to 5p15.2...
  4. Wang T, Chen Y, Hong H, Zeng Y, Zhang J, Lu J, et al. Increased nucleotide polymorphic changes in the 5'-untranslated region of delta-catenin (CTNND2) gene in prostate cancer. Oncogene. 2009;28:555-64 pubmed publisher
    ..delta-Catenin (CTNND2) is overexpressed in cancer, although the mechanisms of its upregulation are highly variable...
  5. Izawa I, Nishizawa M, Ohtakara K, Inagaki M. Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses. J Biol Chem. 2002;277:5345-50 pubmed
    ..containing PDZ domain as bait, and we isolated delta-catenin/neural plakophilin-related armadillo repeat protein (NPRAP) as a Densin-180-interacting protein...
  6. Lu Q, Mukhopadhyay N, Griffin J, Paredes M, Medina M, Kosik K. Brain armadillo protein delta-catenin interacts with Abl tyrosine kinase and modulates cellular morphogenesis in response to growth factors. J Neurosci Res. 2002;67:618-24 pubmed
    ..We suggest that delta-catenin is a possible Abl substrate and acts downstream of Abl to orchestrate actin-based cellular morphogenesis. ..
  7. Martinez M, Ochiishi T, Majewski M, Kosik K. Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho. J Cell Biol. 2003;162:99-111 pubmed
    ..We conclude that delta-catenin contributes to setting a balance between neurite elongation and branching in the elaboration of a complex dendritic tree. ..
  8. Kim K, Oh M, Ki H, Wang T, Bareiss S, Fini M, et al. Identification of E2F1 as a positive transcriptional regulator for delta-catenin. Biochem Biophys Res Commun. 2008;369:414-20 pubmed publisher
  9. Silverman J, Restituito S, Lu W, Lee Edwards L, Khatri L, Ziff E. Synaptic anchorage of AMPA receptors by cadherins through neural plakophilin-related arm protein AMPA receptor-binding protein complexes. J Neurosci. 2007;27:8505-16 pubmed
    ..Here we show that the cadherin-associated protein neural plakophilin-related arm protein (NPRAP; also called delta-catenin) binds via a postsynaptic density-95 (PSD-95)/discs large/zona occludens-1 (PDZ) ..
  10. Lauritano D, Lucchese A, Di Stasio D, Della Vella F, Cura F, Palmieri A, et al. Molecular Aspects of Drug-Induced Gingival Overgrowth: An In Vitro Study on Amlodipine and Gingival Fibroblasts. Int J Mol Sci. 2019;20: pubmed publisher
    ..Most of the significant genes were up-regulated. (CTNND2, COL4A1, ITGA2, ITGA7, MMP10, MMP11, MMP12, MMP26) except for ..
  11. Halder D, Mandal C, Lee B, Lee J, Choi M, Chai J, et al. PCDHB14- and GABRB1-like nervous system developmental genes are altered during early neuronal differentiation of NCCIT cells treated with ethanol. Hum Exp Toxicol. 2015;34:1017-27 pubmed publisher
    ..EtOH exposure downregulated several important genes, such as PCDHB14, GABRB1, CTNND2, NAV3, RALDH1, and OPN5, which are involved in CNS development, synapse assembly, synaptic transmission, and ..
  12. Yuan L, Seong E, Beuscher J, Arikkath J. δ-Catenin Regulates Spine Architecture via Cadherin and PDZ-dependent Interactions. J Biol Chem. 2015;290:10947-57 pubmed publisher
    ..The loss of Ctnnd2, the gene encoding δ-catenin, has been associated with the intellectual disability observed in the cri du chat ..
  13. Huang F, Chen J, Lan R, Wang Z, Chen R, Lin J, et al. Hypoxia induced δ-Catenin to enhance mice hepatocellular carcinoma progression via Wnt signaling. Exp Cell Res. 2019;374:94-103 pubmed publisher
    ..find that the hypoxia-inducible transcriptional factor, HIF1α, can directly upregulate the expression of the gene Ctnnd2, which codes the protein δ-Catenin...
  14. Ma J, Zhao D, Wu Y, Xu C, Zhang F. Cyclic stretch induced gene expression of extracellular matrix and adhesion molecules in human periodontal ligament cells. Arch Oral Biol. 2015;60:447-55 pubmed publisher
    ..ECM proteases (ADAMTS1, ADAMTS8, MMP8) and inhibitors (TIMP1), as well as other adhesion-related molecules (CTGF, CTNND2, TGFBI, CLEC3B)...
  15. Wang H, Yang M, Su S, Kang L, Zhu R, Shi J, et al. [Association of ZNF644, GRM6 and CTNND2 genes polymorphisms with high myopia]. Zhonghua Yi Xue Za Zhi. 2014;94:1289-93 pubmed
    To investigate the association of ZNF644, GRM6 and CTNND2 genes with high myopia in Jiangsu Chinese population. Case-control association study was used in this research...
  16. Workalemahu T, Enquobahrie D, Gelaye B, Sanchez S, Garcia P, Tekola Ayele F, et al. Genetic variations and risk of placental abruption: A genome-wide association study and meta-analysis of genome-wide association studies. Placenta. 2018;66:8-16 pubmed publisher
    ..included rs4148646 and rs2074311 in ABCC8, rs7249210, rs7250184, rs7249100 and rs10401828 in ZNF28, rs11133659 in CTNND2, and rs2074314 and rs35271178 near KCNJ11 in the PAGE GWAS...
  17. Ema A, Waraya M, Yamashita K, Kokubo K, Kobayashi H, Hoshi K, et al. Identification of EGFR expression status association with metastatic lymph node density (ND) by expression microarray analysis of advanced gastric cancer. Cancer Med. 2015;4:90-100 pubmed publisher
    ..1, CHST9, CTNND2, SLC25A27, FGFR2, EGFR, and PTGER1. Of these genes, the EGFR gene was of particular interest...
  18. Maussion G, Diallo A, Gigek C, Chen E, Crapper L, Théroux J, et al. Investigation of genes important in neurodevelopment disorders in adult human brain. Hum Genet. 2015;134:1037-53 pubmed publisher
    ..also performed expression analyses using BrainSpan data for NDD-associated genes SATB2, EHMT1, FMR1, MECP2, MBD5, CTNND2, RAI1, CHD8, GRIN2A, GRIN2B, TCF4, SCN2A, and DYRK1A and find high expression of these genes in adult brain, at ..
  19. Heinonen H, Lepikhova T, Sahu B, Pehkonen H, Pihlajamaa P, Louhimo R, et al. Identification of several potential chromatin binding sites of HOXB7 and its downstream target genes in breast cancer. Int J Cancer. 2015;137:2374-83 pubmed publisher
    ..of a large number of genes located nearby HOXB7 binding sites and found several new direct targets, such as CTNND2 and SCGB1D2...
  20. Chen B, Zhu Z, Wang Y, Ding X, Guo X, He M, et al. Nature vs. nurture in human sociality: multi-level genomic analyses of social conformity. J Hum Genet. 2018;63:605-619 pubmed publisher
    ..tyrosine phosphatase receptor type D), ARL10 (ADP ribosylation factor-like GTPase 10), and CTNND2 (catenin delta 2), with conformity...
  21. Singh V, Singh L, Vasudevan M, Chattopadhyay I, Borthakar B, Rai A, et al. Esophageal Cancer Epigenomics and Integrome Analysis of Genome-Wide Methylation and Expression in High Risk Northeast Indian Population. OMICS. 2015;19:688-99 pubmed publisher
    ..genes (PTK2, RND1, RND3, and UBL3) with promoter hypermethylation and downregulation, and 19 genes (SEMG2, CD97, CTNND2, CADM3, OMD, NEFM, FBN2, CTNNB1, DLX6, UGT2B4, CCDC80, PZP, SERPINA4, TNFSF13B, NPC1, COL1A1, TAC3, BMP8A, and ..
  22. Zhang B, Willing M, Grange D, Shinawi M, Manwaring L, Vineyard M, et al. Multigenerational autosomal dominant inheritance of 5p chromosomal deletions. Am J Med Genet A. 2016;170:583-93 pubmed publisher
    ..This study supports newly recognized effects of aberrant SEMA5A and CTNND2 dosage on severity of autistic and cognitive phenotypes...
  23. Dai S, Wang Y, Zhang J, Zhang D, Zhang P, Jiang G, et al. Upregulation of ?-catenin is associated with poor prognosis and enhances transcriptional activity through Kaiso in non-small-cell lung cancer. Cancer Sci. 2011;102:95-103 pubmed publisher
    ..Increased ?-catenin expression is critical for maintenance of the malignant phenotype of lung cancer, making ?-catenin a candidate target protein for future cancer therapeutics. ..
  24. Lu B, Jiang D, Wang P, Gao Y, Sun W, Xiao X, et al. Replication study supports CTNND2 as a susceptibility gene for high myopia. Invest Ophthalmol Vis Sci. 2011;52:8258-61 pubmed publisher
    The CTNND2 gene is located in the linkage interval of high myopia locus MYP16 and two single-nucleotide polymorphisms (SNPs; rs6885224 and rs12716080) in CTNND2 were recently shown to associate with high myopia...
  25. Einarsdottir E, Peyrard Janvid M, Darki F, Tuulari J, Merisaari H, Karlsson L, et al. Identification of NCAN as a candidate gene for developmental dyslexia. Sci Rep. 2017;7:9294 pubmed publisher
    ..8) with that of the previously suggested DD susceptibility genes KIAA0319, CTNND2, CNTNAP2 and GRIN2B...
  26. Yu Z, Zhou J, Chen X, Zhou X, Sun X, Chu R. Polymorphisms in the CTNND2 gene and 11q24.1 genomic region are associated with pathological myopia in a Chinese population. Ophthalmologica. 2012;228:123-9 pubmed publisher
    ..This study further evaluated the association of polymorphisms in the CTNND2 gene and the 11q24.1 genomic region with pathological myopia...
  27. Huang F, Chen J, Wang Z, Lan R, Fu L, Zhang L. ?-Catenin promotes tumorigenesis and metastasis of lung adenocarcinoma. Oncol Rep. 2018;39:809-817 pubmed publisher
    Catenin coded by gene CTNND2 has been found to be overexpressed in various types of cancers, including prostate, breast, lung and ovarian cancers. However, the function of ?-catenin in lung carcinoma remains largely unknown...
  28. Oh M, Kim H, Yang I, Park J, Cong W, Baek M, et al. GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis. J Biol Chem. 2009;284:28579-89 pubmed publisher
    ..These results suggest that GSK-3 interacts with and phosphorylates delta-catenin and thereby negatively affects its stability by enabling its ubiquitination/proteosome-mediated proteolysis. ..
  29. Zhang J, Bai C, Bai Y, Zhang J, Wu Z, Wang S, et al. The expression of δ-catenin in esophageal squamous cell carcinoma and its correlations with prognosis of patients. Hum Pathol. 2014;45:2014-22 pubmed publisher
    ..Together, our results suggest that δ-catenin acts as an oncoprotein when overexpressed in ESCC, and its expression is associated with poor prognosis and malignant cell behavior. ..
  30. Lam C, Tam P, Fan D, Fan B, Wang D, Lee C, et al. A genome-wide scan maps a novel high myopia locus to 5p15. Invest Ophthalmol Vis Sci. 2008;49:3768-78 pubmed publisher
    ..45-cM interval. The coding sequences of five genes located within this region, IRX2, IRX1, POLS, CCT5, and CTNND2, were screened. No segregation of polymorphism with high myopia was found...
  31. Turner T, Sharma K, Oh E, Liu Y, Collins R, Sosa M, et al. Loss of ?-catenin function in severe autism. Nature. 2015;520:51-6 pubmed publisher
    ..missense and dosage sequence variants in the gene encoding the adhesive junction-associated ?-catenin protein (CTNND2) in female-enriched multiplex families and demonstrating their loss-of-function effect by functional analyses in ..
  32. Simmons A, Overhauser J, Lovett M. Isolation of cDNAs from the Cri-du-chat critical region by direct screening of a chromosome 5-specific cDNA library. Genome Res. 1997;7:118-27 pubmed
    ..This new thrombospondin-like gene, and the other three cDNAs that map within the CDCCR, represent candidate genes for the cri-du-chat contiguous gene deletion syndrome...
  33. Asadollahi R, Oneda B, Joset P, Azzarello Burri S, Bartholdi D, Steindl K, et al. The clinical significance of small copy number variants in neurodevelopmental disorders. J Med Genet. 2014;51:677-88 pubmed publisher
    ..Two further de novo CNVs affecting single genes (MED13L, CTNND2) were instrumental in delineating novel recurrent conditions...
  34. Okamura Oho Y, Miyashita T, Ohmi K, Yamada M. Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate. Hum Mol Genet. 1999;8:947-57 pubmed
    ..The identification of IRSp53 and other proteins detected by the yeast hybrid system predicts that DRPLA functions in a signal transduction pathway coupled with insulin/IGF-1. ..
  35. Bonne S, van Hengel J, van Roy F. Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily. Genomics. 1998;51:452-4 pubmed
    ..localization of the p120(ctn) gene (CTNND1) at 11q11, the ARVCF gene at 22q11, and the delta-catenin/NPRAP gene (CTNND2) at 5p15...
  36. Li Y, Goh L, Khor C, Fan Q, Yu M, Han S, et al. Genome-wide association studies reveal genetic variants in CTNND2 for high myopia in Singapore Chinese. Ophthalmology. 2011;118:368-75 pubmed publisher
    ..00 diopters (D); controls defined by SE between -0.50 and +1.00 D. Two SNPs (rs12716080 and rs6885224) in the gene CTNND2 on chromosome 5p15 ranked top in the meta-analysis of our Chinese datasets (meta P = 1.14 × 10(-5) and meta P = 1...
  37. Koutras C, Lessard C, Levesque G. A nuclear function for the presenilin 1 neuronal partner NPRAP/?-catenin. J Alzheimers Dis. 2011;27:307-16 pubmed publisher
    ..PS1 interacts with several protein partners, including the neural plakophilin-related armadillo protein (NPRAP or ?-catenin)...
  38. Koutras C, Levesque G. Identification of novel NPRAP/?-catenin-interacting proteins and the direct association of NPRAP with dynamin 2. PLoS ONE. 2011;6:e25379 pubmed publisher
    Neural plakophilin-related armadillo protein (NPRAP or ?-catenin) is a neuronal-specific protein that is best known for its interaction with presenilin 1 (PS1)...
  39. Zhang J, Zhang D, Wang E. Overexpression of small GTPases directly correlates with expression of ?-catenin and their coexpression predicts a poor clinical outcome in nonsmall cell lung cancer. Mol Carcinog. 2013;52:338-47 pubmed publisher
    ..Therefore, ?-catenin likely upregulates the activity of small GTPases at transcriptional level, and their coexpression may predict a poor clinical outcome in NSCLC patients. ..
  40. Jun G, Moncaster J, Koutras C, Seshadri S, Buros J, McKee A, et al. δ-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes. PLoS ONE. 2012;7:e43728 pubmed publisher
    ..polymorphisms (SNPs) for the bivariate outcome of CC and THV identified genome-wide significant association with CTNND2 SNPs rs17183619, rs13155993 and rs13170756 (P<2.6 × 10(-7))...
  41. Nopparat J, Zhang J, Lu J, Chen Y, Zheng D, Neufer P, et al. ?-Catenin, a Wnt/?-catenin modulator, reveals inducible mutagenesis promoting cancer cell survival adaptation and metabolic reprogramming. Oncogene. 2015;34:1542-52 pubmed publisher
    ..Here we report that ?-catenin (gene designation: CTNND2), a primarily neural member of the ?-catenin superfamily that promotes canonical Wnt/?-catenin/LEF-1-mediated ..
  42. Ozaki C, Yoshioka M, Tominaga S, Osaka Y, Obata S, Suzuki S. p120-Catenin is essential for N-cadherin-mediated formation of proper junctional structure, thereby establishing cell polarity in epithelial cells. Cell Struct Funct. 2010;35:81-94 pubmed
    ..Similar results were obtained when E-cadherin mutants comparable to those of N-cadherin were used, suggesting that p120-catenin plays the same role in the function of other classical cadherins. ..
  43. Shendre A, Wiener H, Irvin M, Aouizerat B, Overton E, Lazar J, et al. Genome-wide admixture and association study of subclinical atherosclerosis in the Women's Interagency HIV Study (WIHS). PLoS ONE. 2017;12:e0188725 pubmed publisher
    ..complex subunit 30 and exostosin glycosyltransferase 1 (MED30 | EXT1) among all women, rs2907092 in the catenin delta 2 (CTNND2) gene among HIV-positive women, and rs7529733 in the region intergenic to family with sequence ..
  44. Nivard M, Mbarek H, Hottenga J, Smit J, Jansen R, Penninx B, et al. Further confirmation of the association between anxiety and CTNND2: replication in humans. Genes Brain Behav. 2014;13:195-201 pubmed publisher
    The rat genome sequencing and mapping consortium found evidence for an association between the catenin-?2 gene (CTNND2) and anxious behaviour...
  45. Hofmeister W, Nilsson D, Topa A, Anderlid B, Darki F, Matsson H, et al. CTNND2-a candidate gene for reading problems and mild intellectual disability. J Med Genet. 2015;52:111-22 pubmed publisher
    ..By direct sequencing, we then located the chromosome 5p breakpoint to intron 9 of CTNND2. An additional case with a 163 kb microdeletion exclusively involving CTNND2 was identified with genome-..
  46. Yang I, Chang O, Lu Q, Kim K. Delta-catenin affects the localization and stability of p120-catenin by competitively interacting with E-cadherin. Mol Cells. 2010;29:233-7 pubmed publisher
    ..We show that successful binding by either one to E-cadherin adversely affects the stability of the other. ..
  47. Fujita T, Okada T, Hayashi S, Jahangeer S, Miwa N, Nakamura S. Delta-catenin/NPRAP (neural plakophilin-related armadillo repeat protein) interacts with and activates sphingosine kinase 1. Biochem J. 2004;382:717-23 pubmed
    ..Here, we have identified delta-catenin/NPRAP (neural plakophilin-related armadillo repeat protein) as a potential binding partner for SPHK1 by yeast two-hybrid ..
  48. Wang H, Su S, Yang M, Hu N, Yao Y, Zhu R, et al. Association of ZNF644, GRM6, and CTNND2 genes with high myopia in the Han Chinese population: Jiangsu Eye Study. Eye (Lond). 2016;30:1017-22 pubmed publisher
    AimsHigh myopia is a common visual disorder in the world. The ZNF644, GRM6, and CTNND2 genes are expressed in the retina. This study aims to investigate the associations of these genes with high myopia in Han Chinese population...
  49. Lu Q, Aguilar B, Li M, Jiang Y, Chen Y. Genetic alterations of δ-catenin/NPRAP/Neurojungin (CTNND2): functional implications in complex human diseases. Hum Genet. 2016;135:1107-16 pubmed publisher
    ..One such gene stands out: δ-catenin/NPRAP/Neurojungin with gene designation as CTNND2 on chromosome 5p15.2...
  50. van Rootselaar A, Groffen A, de Vries B, Callenbach P, Santen G, Koelewijn S, et al. ?-Catenin (CTNND2) missense mutation in familial cortical myoclonic tremor and epilepsy. Neurology. 2017;: pubmed publisher
    ..To identify the causative gene in a large Dutch family with familial cortical myoclonic tremor and epilepsy (FCMTE)...
  51. Zhang J, Lu J, Suter D, Krause K, Fini M, Chen B, et al. Isoform- and dose-sensitive feedback interactions between paired box 6 gene and delta-catenin in cell differentiation and death. Exp Cell Res. 2010;316:1070-81 pubmed publisher
    ..Pax6(+5a) or Pax6(-5a) was sufficient to promote, whereas their knockdown reduced the expression of delta-catenin (CTNND2), a neural specific member of the armadillo/beta-catenin superfamily...
  52. Zhang D, Zhang J, Dai S, Liu S, Liu Y, Tang N, et al. Co-expression of delta-catenin and RhoA is significantly associated with a malignant lung cancer phenotype. Int J Clin Exp Pathol. 2014;7:3724-32 pubmed
    ..We also demonstrate that delta-catenin can directly interact with RhoA and regulate its activity, which in turn mediates tumor invasion and metastasis. ..
  53. Belcaro C, Dipresa S, Morini G, Pecile V, Skabar A, Fabretto A. CTNND2 deletion and intellectual disability. Gene. 2015;565:146-9 pubmed publisher
    ..Moreover, small CNVs involving single genes might result in a monogenic disease. In this article we report two cases of intragenic CTNND2 deletion, detected by molecular karyotyping, in patients with isolated intellectual disability.
  54. Stenzel N, Fetzer C, Heumann R, Erdmann K. PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells. J Cell Sci. 2009;122:3374-84 pubmed publisher
    ..Our results provide novel insights into the molecular function of FRMPD2 and into the targeting mechanism of peripheral membrane proteins in polarized epithelial cells. ..
  55. Lu J, Zhang J, Kim K, Case T, Matusik R, Chen Y, et al. Human homolog of Drosophila Hairy and enhancer of split 1, Hes1, negatively regulates ?-catenin (CTNND2) expression in cooperation with E2F1 in prostate cancer. Mol Cancer. 2010;9:304 pubmed publisher
    Neuronal synaptic junction protein ?-catenin (CTNND2) is often overexpressed in prostatic adenocarcinomas but the mechanisms of its activation are unknown...