Gene Symbol: CTNNAL1
Description: catenin alpha like 1
Alias: ACRP, CLLP, alpha-CATU, alpha-catulin, alpha-catenin-related protein, alpha2-catulin, catenin (cadherin-associated protein), alpha-like 1, catenin alpha-like protein 1
Species: human
Products:     CTNNAL1

Top Publications

  1. Zhang J, Nelson M, Wang L, Liu W, Qian C, Shridhar V, et al. Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin. Genomics. 1998;54:149-54 pubmed
    ..This produced a protein product of about 82 kDa in size. The gene designated as CTNNAL1 (catenin (cadherin-associated protein), alpha-like 1) was found to be ubiquitously expressed in many tissues ..
  2. Park B, Nguyen N, Dutt P, Merdek K, Bashar M, Sterpetti P, et al. Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. J Biol Chem. 2002;277:45361-70 pubmed
    ..The human alpha-catulin gene (CTNNAL1) maps to 9q31-32...
  3. Xiang Y, Tan Y, Zhang J, Qin X, Hu B, Wang Y, et al. Wound repair and proliferation of bronchial epithelial cells regulated by CTNNAL1. J Cell Biochem. 2008;103:920-30 pubmed
    ..Our previous study indicated that adhesion molecule catenin alpha-like 1 (CTNNAL1) is relevant closely to asthma susceptibility, but its biological function or significance is still unclear...
  4. Liang C, Chiu S, Hsu I, Wu Y, Tsai Y, Ke J, et al. ?-Catulin drives metastasis by activating ILK and driving an ?v?3 integrin signaling axis. Cancer Res. 2013;73:428-38 pubmed publisher
    ..Taken together, our study shows that ?-catulin plays a critical role in cancer metastasis by activating the ILK-mediated Akt-NF-?B-?v?3 signaling axis. ..
  5. Fan L, Chiang W, Liang C, Tsai Y, Wong T, Chen K, et al. ?-Catulin knockdown induces senescence in cancer cells. Oncogene. 2011;30:2610-21 pubmed publisher
    ..Our study provides evidence that ?-catulin promotes tumor growth by preventing cellular senescence and suggests that downregulating ?-catulin may be a promising therapeutic approach for cancer treatment. ..
  6. Janssens B, Staes K, van Roy F. Human alpha-catulin, a novel alpha-catenin-like molecule with conserved genomic structure, but deviating alternative splicing. Biochim Biophys Acta. 1999;1447:341-7 pubmed
    ..The genomic organization of the alpha-catulin gene CTNNAL1 is closely related to that of the alphaE-catenin gene CTNNA1, but not at all to that of the vinculin gene...
  7. Wiesner C, Winsauer G, Resch U, Hoeth M, Schmid J, van Hengel J, et al. Alpha-catulin, a Rho signalling component, can regulate NF-kappaB through binding to IKK-beta, and confers resistance to apoptosis. Oncogene. 2008;27:2159-69 pubmed
    ..Together, these features suggest that alpha-catulin has tumorigenic potential. ..
  8. Merdek K, Nguyen N, Toksoz D. Distinct activities of the alpha-catenin family, alpha-catulin and alpha-catenin, on beta-catenin-mediated signaling. Mol Cell Biol. 2004;24:2410-22 pubmed
    ..These results suggest a novel function for alpha-catulin and imply that alpha-catenin and alpha-catulin have distinct activities that downregulate, respectively, beta-catenin and Ras signals converging on the cyclin D1 promoter. ..
  9. Kreiseder B, Orel L, Bujnow C, Buschek S, Pflueger M, Schuett W, et al. ?-Catulin downregulates E-cadherin and promotes melanoma progression and invasion. Int J Cancer. 2013;132:521-30 pubmed publisher
    ..Catulin (CTNNAL1) is a cytoplasmic molecule that integrates the crosstalk between nuclear factor-kappa B and Rho signaling ..

More Information


  1. Cao C, Chen Y, Masood R, Sinha U, Kobielak A. ?-Catulin marks the invasion front of squamous cell carcinoma and is important for tumor cell metastasis. Mol Cancer Res. 2012;10:892-903 pubmed publisher
    ..Overall, these results strongly indicate that ?-catulin contributes to the invasive behavior of metastatic cells and may be used as a prognostic marker and future therapeutic target for patients with cancer. ..
  2. Acar M, Kocherlakota K, Murphy M, Peyer J, Oguro H, Inra C, et al. Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal. Nature. 2015;526:126-30 pubmed publisher
    ..Here, using a green fluorescent protein (GFP) knock-in for the gene Ctnnal1 in mice (hereafter denoted as α-catulin(GFP)), we discover that α-catulin(GFP) is expressed by only 0...
  3. Bear M, Liu T, Abualkhair S, Ghamloush M, Hill N, Preston I, et al. Alpha-Catulin Co-Localizes With Vimentin Intermediate Filaments and Functions in Pulmonary Vascular Endothelial Cell Migration via ROCK. J Cell Physiol. 2016;231:934-43 pubmed publisher
    ..J. Cell. Physiol. 231: 934-943, 2016. © 2015 Wiley Periodicals, Inc. ..
  4. Zhang Q, Liu S, Liu Y, Hua Y, Song H, Ren Y, et al. Achieving low density lipoprotein-cholesterol<70mg/dL may be associated with a trend of reduced progression of carotid artery atherosclerosis in ischemic stroke patients. J Neurol Sci. 2017;378:26-29 pubmed publisher
    ..Mean change in atherosclerotic plaque length was -1.4mm (95% CI: [-4.1, 1, 2]; P=0.27) in ILLT and 1.1mm in CLLP group (95% CI: [-0.9, 3.1]; P=0.27); no difference between groups (P=0.40)...
  5. Bear M, Li M, Liu Y, Giel Moloney M, Fanburg B, Toksoz D. The Lbc Rho guanine nucleotide exchange factor ?-catulin axis functions in serotonin-induced vascular smooth muscle cell mitogenesis and RhoA/ROCK activation. J Biol Chem. 2010;285:32919-26 pubmed publisher
    ..Thus, the Lbc/?-catulin axis participates in 5-HT-induced PASMC mitogenesis and RhoA/ROCK signaling, and may be an interventional target in diseases involving vascular smooth muscle remodeling. ..
  6. Buimer M, Keijser R, Jebbink J, Wehkamp D, van Kampen A, Boer K, et al. Seven placental transcripts characterize HELLP-syndrome. Placenta. 2008;29:444-53 pubmed publisher
    ..This distinct placental molecular signature suggests that HELLP is not a PE variant but a separate disease entity. Our data may prove fundamental for the further molecular analysis of PE and HELLP syndrome. ..
  7. Zhang Z, Yang X, Huang K, Ren L, Zhao S, Gou W, et al. The upregulated α-catulin expression was involved in head-neck squamous cell carcinogenesis by promoting proliferation, migration, invasion, and epithelial to mesenchymal transition. Tumour Biol. 2016;37:1671-81 pubmed publisher
    ..It might be regarded as a potential marker for head and neck carcinogenesis or a target of gene therapy for HNSCCs. ..
  8. Surpili M, Delben T, Kobarg J. Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1. Biochemistry. 2003;42:15369-76 pubmed
    ..Our results give further support to the previous observation that NEK1 is of functional importance for the etiology of PKD. ..
  9. Gascoyne D, Lyne L, Spearman H, Buffa F, Soilleux E, Banham A. Vitamin D Receptor Expression in Plasmablastic Lymphoma and Myeloma Cells Confers Susceptibility to Vitamin D. Endocrinology. 2017;158:503-515 pubmed publisher
    ..profiling identified plasmablastic characteristics in DLBCL cell lines HLY-1 and SU-DHL-9, associated with CTNNAL1, HPGD, RORA, IGF1, and/or vitamin D receptor (VDR) transcription...
  10. Xiang Y, Qin X, Liu H, Tan Y, Liu C, Liu C. Identification of transcription factors regulating CTNNAL1 expression in human bronchial epithelial cells. PLoS ONE. 2012;7:e31158 pubmed publisher
    ..Our previous study indicated catenin alpha-like 1 (CTNNAL1), an alpha-catenin-related protein, was downregulated in asthma patients and animal model...
  11. Lyssand J, Whiting J, Lee K, Kastl R, Wacker J, Bruchas M, et al. Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome. Proc Natl Acad Sci U S A. 2010;107:21854-9 pubmed publisher
    ..Taken together, our study implicates ?-catulin as a unique regulator of GPCR signaling and represents a unique expansion of the intricate and continually evolving array of GPCR signaling networks. ..
  12. Kreiseder B, Holper Schichl Y, Muellauer B, Jacobi N, Pretsch A, Schmid J, et al. Alpha-catulin contributes to drug-resistance of melanoma by activating NF-κB and AP-1. PLoS ONE. 2015;10:e0119402 pubmed publisher
    ..The cytoskeletal linker protein α-catulin (CTNNAL1) has been shown to be important in inflammation, apoptosis and cytoskeletal reorganization...
  13. Shieh Y, Chang L, Chiu K, Wu C, Lee H. Cadherin and catenin expression in mucoepidermoid carcinoma: correlation with histopathologic grade, clinical stage, and patient outcome. J Oral Pathol Med. 2003;32:297-304 pubmed
    ..The roles of cadherins and catenins in mucoepidermoid carcinoma (MEC) are not fully understood...
  14. Demacio P, Ray P. Alpha-catulin maps to the familial dysautonomia region on 9q31. Genome. 2001;44:990-4 pubmed
    ..Because of the presence of these sequence variants in several unaffected individuals, alpha-catulin is unlikely to be the causative gene in this disease. ..