Gene Symbol: CTH
Description: cystathionine gamma-lyase
Alias: cystathionine gamma-lyase, cystathionase (cystathionine gamma-lyase), cysteine desulfhydrase, cysteine-protein sulfhydrase, gamma-cystathionase, homoserine deaminase, homoserine dehydratase
Species: human
Products:     CTH

Top Publications

  1. You X, Xu C, Lu J, Zhu X, Gao L, Cui X, et al. Expression of cystathionine ?-synthase and cystathionine ?-lyase in human pregnant myometrium and their roles in the control of uterine contractility. PLoS ONE. 2011;6:e23788 pubmed publisher
    ..Hydrogen sulfide (H(2)S) has recently been shown to play a key role in the control of smooth muscle tension. The role of endogenous H(2)S produced locally in the control of uterine contractility during labour is unknown...
  2. Yang G, Pei Y, Cao Q, Wang R. MicroRNA-21 represses human cystathionine gamma-lyase expression by targeting at specificity protein-1 in smooth muscle cells. J Cell Physiol. 2012;227:3192-200 pubmed publisher
    ..Take together, these results suggest that miR-21 participates in CSE/H(2)S-mediated-SMC differentiation by targeting SP1. ..
  3. Mazzio E, Lewis C, Soliman K. Transcriptomic Profiling of MDA-MB-231 Cells Exposed to Boswellia Serrata and 3-O-Acetyl-B-Boswellic Acid; ER/UPR Mediated Programmed Cell Death. Cancer Genomics Proteomics. 2017;14:409-425 pubmed
    ..01]; and cystathionine gamma-lyase (CTH) [+11.12]...
  4. Schwabl P, Hambruch E, Seeland B, Hayden H, Wagner M, Garnys L, et al. The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction. J Hepatol. 2017;66:724-733 pubmed publisher
    ..Thus, PX20606 leads to an improved blood flow through the liver and decreases hypertension of the portal vein. Additionally, PX20606 improves the altered intestinal barrier and decreases bacterial migration from the gut. ..
  5. Alix Panabières C, Cayrefourcq L, Mazard T, Maudelonde T, Assenat E, Assou S. Molecular Portrait of Metastasis-Competent Circulating Tumor Cells in Colon Cancer Reveals the Crucial Role of Genes Regulating Energy Metabolism and DNA Repair. Clin Chem. 2017;63:700-713 pubmed publisher
    ..stemness [glutaminase 2 (GLS2), cystathionine-beta-synthase (CBS), and cystathionine gamma-lyase (CTH)]. The differential expression of 20 genes was validated by quantitative reverse transcription PCR...
  6. Mishra P, Givvimani S, Metreveli N, Tyagi S. Attenuation of beta2-adrenergic receptors and homocysteine metabolic enzymes cause diabetic cardiomyopathy. Biochem Biophys Res Commun. 2010;401:175-81 pubmed publisher
    ..ATP-ase-isoform 2 (SERCA-2) and homocysteine (Hcy) metabolic enzymes-cystathionine beta synthase (CBS), cystathionine gamma lyase (CTH), and methyl tetrahydrofolate reductase (MTHFR) were determined in the heart...
  7. Rajpal S, Katikaneni P, Deshotels M, Pardue S, Glawe J, Shen X, et al. Total sulfane sulfur bioavailability reflects ethnic and gender disparities in cardiovascular disease. Redox Biol. 2018;15:480-489 pubmed publisher
    ..SNP analysis of H2S synthesizing enzymes and found a significant increase in cystathionine gamma-lyase (CTH) 1364?G-T allele frequency in patients with CVD compared to controls...
  8. Ahmed A, Rezai H, Broadway Stringer S. Evidence-Based Revised View of the Pathophysiology of Preeclampsia. Adv Exp Med Biol. 2017;956:355-374 pubmed publisher
    ..Likewise, hydrogen sulphide (H2S)/cystathionine-?-lyase (Cth) systems limit sFlt-1 and sEng and protect against the preeclampsia phenotype in mice...
  9. Osorio J, Batistel F, Garrett E, Elhanafy M, Tariq M, Socha M, et al. Corium molecular biomarkers reveal a beneficial effect on hoof transcriptomics in peripartal dairy cows supplemented with zinc, manganese, and copper from amino acid complexes and cobalt from cobalt glucoheptonate. J Dairy Sci. 2016;99:9974-9982 pubmed publisher
    ..Downregulation of KRT5, CTH, CALML5, and CYBB, and upregulation of BTD in AAC cows indicated a decrease in the need for activation of cellular ..

More Information

Publications120 found, 100 shown here

  1. Hughes C, McConechy M, Cochrane D, Nazeran T, Karnezis A, Huntsman D, et al. Quantitative Profiling of Single Formalin Fixed Tumour Sections: proteomics for translational research. Sci Rep. 2016;6:34949 pubmed publisher
    ..A tissue microarray analysis validated cystathionine gamma-lyase (CTH) as a novel clear cell carcinoma feature with potential clinical relevance...
  2. Nechiporuk V, Zaichko N, Korda М, Melnyk A, Koloshko O. SULPHUR-CONTAINING AMINO ACIDS METABOLISM IN EXPERIMENTAL HYPER- AND HYPOTHYROIDISM IN RATS. Georgian Med News. 2017;:96-102 pubmed
  3. Zhang T, Wei W, Dirsch O, Krüger T, Kan C, Xie C, et al. Identification of Proteins Interacting with Cytoplasmic High-Mobility Group Box 1 during the Hepatocellular Response to Ischemia Reperfusion Injury. Int J Mol Sci. 2017;18: pubmed publisher
    ..using Western blotting: betaine-homocysteine S-methyltransferase 1 (BHMT) and cystathionine ?-lyase (CTH). Therefore, our results revealed the binding of HMGB1 to BHMT and CTH in cytoplasm during hepatic WI/R...
  4. Pinto J, Krasnikov B, Alcutt S, Jones M, Dorai T, Villar M, et al. Kynurenine aminotransferase III and glutamine transaminase L are identical enzymes that have cysteine S-conjugate β-lyase activity and can transaminate L-selenomethionine. J Biol Chem. 2014;289:30950-61 pubmed publisher
  5. Ahmed A, Ramma W. Unravelling the theories of pre-eclampsia: are the protective pathways the new paradigm?. Br J Pharmacol. 2015;172:1574-86 pubmed publisher
    ..pathways of haem oxygenase 1 (also referred as Hmox1 or HO-1) and cystathionine-γ-lyase (also known as CSE or Cth), which generate carbon monoxide (CO) and hydrogen sulphide (H2S) respectively...
  6. Singh V, Singh S, Kumar J, Prasad S. Hydrogen sulfide alleviates toxic effects of arsenate in pea seedlings through up-regulation of the ascorbate-glutathione cycle: Possible involvement of nitric oxide. J Plant Physiol. 2015;181:20-9 pubmed publisher
    ..As(V) treatment also reduced the activities of cysteine desulfhydrase and nitrate reductase, and contents of H2S and nitric oxide (NO)...
  7. Scuffi D, Nietzel T, Di Fino L, Meyer A, Lamattina L, Schwarzlander M, et al. Hydrogen Sulfide Increases Production of NADPH Oxidase-Dependent Hydrogen Peroxide and Phospholipase D-Derived Phosphatidic Acid in Guard Cell Signaling. Plant Physiol. 2018;176:2532-2542 pubmed publisher
    ..Our results revealed the involvement of H2S in the signaling network that controls stomatal closure, and suggest that H2S regulates NADPH oxidase and PLD activity in guard cells. ..
  8. Martin Lorenzo M, Gonzalez Calero L, Ramos Barron A, Sanchez Niño M, Gomez Alamillo C, García Segura J, et al. Urine metabolomics insight into acute kidney injury point to oxidative stress disruptions in energy generation and H2S availability. J Mol Med (Berl). 2017;95:1399-1409 pubmed publisher
    ..Enzymatic expression changes may be the potentially underlying cause of changes in urine metabolites. Identified metabolite changes link oxidative stress, energy generation, and H2S availability to AKI. ..
  9. Zhou Z, Ferdous F, Montagner P, Luchini D, Corrêa M, Loor J. Methionine and choline supply during the peripartal period alter polymorphonuclear leukocyte immune response and immunometabolic gene expression in Holstein cows. J Dairy Sci. 2018;101:10374-10382 pubmed publisher
    ..In agreement with plasma taurine, oxidative stress-related genes (CBS, CTH, GPX1, GSS, SOD2) in PMNL were lower in response to MET and to CHOL supply...
  10. Nevoral J, Žalmanová T, Zámostná K, Kott T, Kučerová Chrpová V, Bodart J, et al. Endogenously produced hydrogen sulfide is involved in porcine oocyte maturation in vitro. Nitric Oxide. 2015;51:24-35 pubmed publisher
    ..In this study, we observed the presence of Cystathionine β-Synthase (CBS), Cystathionine γ-Lyase (CTH) and 3-Mercaptopyruvate Sulfurtransferase (3-MPST), hydrogen sulfide-releasing enzymes, in porcine oocytes...
  11. Shimada T, Tanaka K, Ishihama A. Transcription factor DecR (YbaO) controls detoxification of L-cysteine in Escherichia coli. Microbiology. 2016;162:1698-1707 pubmed publisher
    ..enterica and Pantoea ananatis, YbaO homologues were identified to regulate the adjacent gene encoding cysteine desulfhydrase for detoxification of cysteine...
  12. Roman G, Mancera Páez O, Bernal C. Epigenetic Factors in Late-Onset Alzheimer's Disease: MTHFR and CTH Gene Polymorphisms, Metabolic Transsulfuration and Methylation Pathways, and B Vitamins. Int J Mol Sci. 2019;20: pubmed publisher
    ..A common mutation (1364T/T) of the cystathionine-γ-lyase (CTH) gene affects the enzyme that converts cystathionine to cysteine in the transsulfuration pathway causing plasma ..
  13. Tang G, Zhang L, Yang G, Wu L, Wang R. Hydrogen sulfide-induced inhibition of L-type Ca2+ channels and insulin secretion in mouse pancreatic beta cells. Diabetologia. 2013;56:533-41 pubmed publisher
    ..The whole-cell patch-clamp technique was used to record VDCCs in beta cells from Cse (also known as Cth)-knockout (KO) and wild-type (WT) mice...
  14. Ostrakhovitch E, Akakura S, Sanokawa Akakura R, Goodwin S, Tabibzadeh S. Dedifferentiation of cancer cells following recovery from a potentially lethal damage is mediated by H2S-Nampt. Exp Cell Res. 2015;330:135-50 pubmed publisher
    ..of NAD(+) and up-regulation of H2S producing enzymes, cystathionine beta synthase (CBS) and cystathionase (CTH) with 3-mercaptopyruvate sulfurtransferase (MST) being detectable only in 3D spheroids...
  15. Kabil O, Yadav V, Banerjee R. Heme-dependent Metabolite Switching Regulates H2S Synthesis in Response to Endoplasmic Reticulum (ER) Stress. J Biol Chem. 2016;291:16418-16423 pubmed publisher
    ..Used acutely, it regulates H2S synthesis; used chronically, it might contribute to disease pathology. ..
  16. Li Z. Analysis of some enzymes activities of hydrogen sulfide metabolism in plants. Methods Enzymol. 2015;555:253-69 pubmed publisher
    ..The level of H2S in plant cells is regulated by its synthetic and degradative enzymes, L-/D-cysteine desulfhydrase (L-/D-DES), sulfite reductase (SiR), and cyanoalanine synthase (CAS), which are responsible for H2S ..
  17. Seale L, Ha H, Hashimoto A, Berry M. Relationship between selenoprotein P and selenocysteine lyase: Insights into selenium metabolism. Free Radic Biol Med. 2018;: pubmed publisher
    ..which would result in available selenocompounds being decomposed by the actions of cystathionine ?-lyase (CGL or CTH) and cystathionine ?-synthase (CBS)...
  18. Smirnova L, Harris G, Delp J, Valadares M, Pamies D, Hogberg H, et al. A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis. Arch Toxicol. 2016;90:2725-2743 pubmed
    ..and MPP+, perturbed genes involved in one-carbon metabolism and transsulfuration pathways (ASS1, CTH, and SHTM2) as in 2D cultures...
  19. Ye X, Xue Y, Ling T, Wang Y, Yu X, Cheng C, et al. Cinnamaldehyde Ameliorates Cadmium-Inhibited Root Elongation in Tobacco Seedlings via Decreasing Endogenous Hydrogen Sulfide Production. Molecules. 2016;22: pubmed publisher
    ..CA blocked the Cd-induced increase in the endogenous H₂S level through the down-regulation of d-cysteine desulfhydrase (DCD) expression...
  20. Su Y, Zhao Y, Wu N, Chen Y, Zhang W, Qiao D, et al. Chromium removal from solution by five photosynthetic bacteria isolates. Appl Microbiol Biotechnol. 2018;102:1983-1995 pubmed publisher
    ..bacteria, strains SC01 and SC05 presented the highest removal rates of chromium ions and the activity of cysteine desulfhydrase under Cr stress...
  21. Li Z, Xie L, Li X. Hydrogen sulfide acts as a downstream signal molecule in salicylic acid-induced heat tolerance in maize (Zea mays L.) seedlings. J Plant Physiol. 2015;177:121-7 pubmed publisher
    ..In addition, treatment with SA enhanced the activity of L-cysteine desulfhydrase (L-DES), a key enzyme in H2S biosynthesis, which in turn induced accumulation of endogenous H2S...
  22. da Silva C, Batista Fontes E, Modolo L. Salinity-induced accumulation of endogenous H2S and NO is associated with modulation of the antioxidant and redox defense systems in Nicotiana tabacum L. cv. Havana. Plant Sci. 2017;256:148-159 pubmed publisher
    ..This increase was correlated with the raise of l-Cys and l-Arg and the induction of l-cysteine desulfhydrase, cyanoalanine synthase, cysteine synthase, nitrate reductase and arginase, enzymes known to be involved in ..
  23. Aroca A, Schneider M, Scheibe R, Gotor C, Romero L. Hydrogen Sulfide Regulates the Cytosolic/Nuclear Partitioning of Glyceraldehyde-3-Phosphate Dehydrogenase by Enhancing its Nuclear Localization. Plant Cell Physiol. 2017;58:983-992 pubmed publisher
    ..protein (GFP) and GapC2-GFP transgenic plants in both the wild type and the des1 mutant defective in the l-cysteine desulfhydrase DES1, responsible for the generation of sulfide in the cytosol...
  24. Liu D, Lu J, Li H, Wang J, Pei Y. Characterization of the O-acetylserine(thiol)lyase gene family in Solanum lycopersicum L. Plant Mol Biol. 2019;99:123-134 pubmed publisher
    ..SlOAS2 also functioned as an L-cysteine desulfhydrase, but its expression pattern was very different from that of SlOAS4...
  25. Yang H, Mao Y, Tan B, Luo S, Zhu Y. The protective effects of endogenous hydrogen sulfide modulator, S-propargyl-cysteine, on high glucose-induced apoptosis in cardiomyocytes: A novel mechanism mediated by the activation of Nrf2. Eur J Pharmacol. 2015;761:135-43 pubmed publisher
    ..Knockdown of Nrf2 by shRNA also blocked SPRC up-regulated expression of CSE. Similar results of protein expression and hypoglycemic activity of SPRC were observed in STZ induced diabetic rats. ..
  26. Wang T, Gao T, Niu X, Xing X, Yang Y, Liu Y, et al. Clinical Characteristics and Prognostic Analysis of Glioma in Human Immunodeficiency Virus-Infected Patients. World Neurosurg. 2018;114:e218-e223 pubmed publisher
    ..The median survival of all HIV-infected patients with gliomas was shorter than that of GBM patients with glioblastoma multiforme. Surgery and WHO grade were independent prognostic factors for OS. ..
  27. Banerjee R, Chiku T, Kabil O, Libiad M, Motl N, Yadav P. Assay methods for H2S biogenesis and catabolism enzymes. Methods Enzymol. 2015;554:189-200 pubmed publisher
    ..The products of the sulfide oxidation pathway are thiosulfate and sulfate. Assays for enzymes involved in the production and oxidative clearance of sulfide to thiosulfate are described in this chapter. ..
  28. Hussain M, Bhuiyan A, Ishikawa H, Theodore Smith R, Schuman J, Kotagiri R. An automated method for choroidal thickness measurement from Enhanced Depth Imaging Optical Coherence Tomography images. Comput Med Imaging Graph. 2018;63:41-51 pubmed publisher
    ..This method is tested on 190 B-scans of 10 subjects against choroid thickness (CTh) results produced manually by two graders...
  29. Gong J, Du X, Li Z, Li X, Guo M, Lu J, et al. Differential expression of genes identified by suppression subtractive hybridization in liver and adipose tissue of gerbils with diabetes. PLoS ONE. 2018;13:e0191212 pubmed publisher
    ..of 17 genes most possibly associated with diabetes was analyzed and seven genes (Sardh, Slc39a7, Pfn1, Arg1, Cth, Sod1 and P4hb) in the liver and one gene (Fabp4) in the adipose tissue were identified that were significantly ..
  30. Yang L, Liu Y, Zhang N, Ding X, Zhang W, Shen K, et al. Novel impact of the DNMT3A R882H mutation on GSH metabolism in a K562 cell model established by TALENs. Oncotarget. 2017;8:30395-30409 pubmed publisher
    ..Further RNA microarray analysis revealed that some genes crucial for glutathione (GSH) synthesis, including CTH, PSPH, PSAT1 and especially SLC7A11 (the cysteine/glutamate transporter) were significantly up-regulated, which ..
  31. Schlegel A, Danot O, Richet E, Ferenci T, Boos W. The N terminus of the Escherichia coli transcription activator MalT is the domain of interaction with MalY. J Bacteriol. 2002;184:3069-77 pubmed
    ..These mutations are located at positions 38, 220, 243, and 359, most likely defining the interaction patch with Aes on the three-dimensional structure of MalT...
  32. Iciek M, Bilska Wilkosz A, Górny M, Sokołowska Jezewicz M, Kowalczyk Pachel D. The Effects of Different Garlic-Derived Allyl Sulfides on Anaerobic Sulfur Metabolism in the Mouse Kidney. Antioxidants (Basel). 2016;5: pubmed
    ..Thus, it can be concluded that garlic-derived DADS and DATS can be a source of sulfane sulfur for renal cells but they are not connected with persulfide formation. ..
  33. Aroca A, Benito J, Gotor C, Romero L. Persulfidation proteome reveals the regulation of protein function by hydrogen sulfide in diverse biological processes in Arabidopsis. J Exp Bot. 2017;68:4915-4927 pubmed publisher
    ..analysis approach for the detection of endogenous persulfidated proteins in wild-type Arabidopsis and L-CYSTEINE DESULFHYDRASE 1 mutant leaves using the tag-switch method...
  34. Johnstone C, Tebbutt N, Abud H, White S, Stenvers K, Hall N, et al. Characterization of mouse A33 antigen, a definitive marker for basolateral surfaces of intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2000;279:G500-10 pubmed
    ..of a growing subfamily within the immunoglobulin superfamily, which includes transmembrane proteins CTX/ChT1, CTM/CTH, and CAR...
  35. Guo L, Harnedy P, O Keeffe M, Zhang L, Li B, Hou H, et al. Fractionation and identification of Alaska pollock skin collagen-derived mineral chelating peptides. Food Chem. 2015;173:536-42 pubmed publisher
    ..A collagen tryptic hydrolysate (CTH), previously shown to chelate iron, was further investigated for the presence of Ca, Fe and Cu chelating peptides...
  36. Zhao H, Ge Y, Wang Z. [Supervised locally linear embedding for magnetic resonance imaging based Alzheimer's disease classification]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2018;35:613-620 pubmed publisher
    ..412 例受试者的大脑皮质厚度(cth)和脑感兴趣区域体积(voi)特征进行提取,减少其冗余特征以提高识别精度。受试者来..
  37. Müller A, Mould W, Freeman W, McBee N, Lane K, Dlugash R, et al. The Incidence of Catheter Tract Hemorrhage and Catheter Placement Accuracy in the CLEAR III Trial. Neurocrit Care. 2018;29:23-32 pubmed publisher
    Incidence of catheter tract hemorrhage (CTH) after initial ventriculostomy placement ranges from 10 to 34%...
  38. Bertelsen B, Nazaryan Petersen L, Sun W, Mehrjouy M, Xie G, Chen W, et al. A germline chromothripsis event stably segregating in 11 individuals through three generations. Genet Med. 2016;18:494-500 pubmed publisher
    Parentally transmitted germ-line chromothripsis (G-CTH) has been identified in only a few cases...
  39. Larisch N, Kirsch S, Schambony A, Studtrucker T, Böckmann R, Dietrich P. The function of the two-pore channel TPC1 depends on dimerization of its carboxy-terminal helix. Cell Mol Life Sci. 2016;73:2565-81 pubmed publisher
    ..Here, we discovered that the dimerization of a predicted helix within the carboxyl-terminus (CTH) is essential for the activity of TPC1...
  40. Kannuchamy S, Mukund N, Saleena L. Genetic engineering of Clostridium thermocellum DSM1313 for enhanced ethanol production. BMC Biotechnol. 2016;16 Suppl 1:34 pubmed publisher
    ..cloned in pNW33N, and transformed to Clostridium thermocellum DSM 1313 by electroporation to generate recombinant CTH-pdc, CTH-adh and CTH-pdc-adh strains that carried heterologous pdc, adh, and both genes, respectively...
  41. Langness S, Ward E, Halbach J, Lizardo R, Davenport K, Bickler S, et al. Plasma D-dimer safely reduces unnecessary CT scans obtained in the evaluation of pediatric head trauma. J Pediatr Surg. 2018;53:752-757 pubmed publisher
    ..of TBI and evaluated the degree by which D-dimer could limit unnecessary computed tomography scans of the head (CTH)...
  42. Cindrova Davies T, Herrera E, Niu Y, Kingdom J, Giussani D, Burton G. Reduced cystathionine ?-lyase and increased miR-21 expression are associated with increased vascular resistance in growth-restricted pregnancies: hydrogen sulfide as a placental vasodilator. Am J Pathol. 2013;182:1448-58 pubmed publisher
    ..These results demonstrate that H2S is a powerful vasodilator of the placental vasculature and that expression of CSE is reduced in placentas associated with increased vascular resistance. ..
  43. Kožich V, Krijt J, Sokolová J, Melenovská P, Ješina P, Vozdek R, et al. Thioethers as markers of hydrogen sulfide production in homocystinurias. Biochimie. 2016;126:14-20 pubmed publisher
    ..enzymes in the transsulfuration pathway of homocysteine -cystathionine beta-synthase (CBS) and gamma-cystathionase (CTH)-use cysteine and/or homocysteine to produce the important signaling molecule hydrogen sulfide (H2S) and ..
  44. Takumi K, Nonaka G. Bacterial Cysteine-Inducible Cysteine Resistance Systems. J Bacteriol. 2016;198:1384-92 pubmed publisher
    ..One locus, designated ccdA(formerly PAJ_0331), encodes a novel cysteine-inducible cysteine desulfhydrase (CD) that degrades cysteine, and its expression is controlled by the transcriptional regulator encoded ..
  45. Vaqué Alcázar L, Sala Llonch R, Valls Pedret C, Vidal Piñeiro D, Fernández Cabello S, Bargalló N, et al. Differential age-related gray and white matter impact mediates educational influence on elders' cognition. Brain Imaging Behav. 2017;11:318-332 pubmed publisher
    ..between education, speed of processing (SP), memory and two brain integrity measures: cortical thickness (CTh) of gray matter (GM) and fractional anisotropy (FA) in the white matter (WM)...
  46. Himabindu P, Anupama K. Decreased Expression of Stable RNA Can Alleviate the Lethality Associated with RNase E Deficiency in Escherichia coli. J Bacteriol. 2017;199: pubmed publisher
    ..Although the C-terminal half (CTH), beyond residue approximately 500, of RNase E is dispensable for viability, deletion of the CTH is lethal when ..
  47. Bronowicka Adamska P, Wróbel M, Magierowski M, Magierowska K, Kwiecień S, Brzozowski T. Hydrogen Sulphide Production in Healthy and Ulcerated Gastric Mucosa of Rats. Molecules. 2017;22: pubmed publisher
    ..2.1.22), cystathionase γ-liase (CTH, EC, and a third, 3-mercaptopyruvate sulfurtransferase (MPST, EC
  48. Chang E, Chang Y, Shun C, Tien Y, Tsai S, Hee S, et al. Inhibition of Prostaglandin Reductase 2, a Putative Oncogene Overexpressed in Human Pancreatic Adenocarcinoma, Induces Oxidative Stress-Mediated Cell Death Involving xCT and CTH Gene Expressions through 15-Keto-PGE2. PLoS ONE. 2016;11:e0147390 pubmed publisher
    ..15-keto-PGE2 suppressed the expressions of solute carrier family 7 member 11 (xCT) and cystathionine gamma-lyase (CTH), two important providers of intracellular cysteine for the generation of glutathione (GSH), which is widely ..
  49. Markó L, Szijártó I, Filipović M, Kaßmann M, Balogh A, Park J, et al. Role of Cystathionine Gamma-Lyase in Immediate Renal Impairment and Inflammatory Response in Acute Ischemic Kidney Injury. Sci Rep. 2016;6:27517 pubmed publisher
    ..Here, we analyzed the role of cystathionine gamma-lyase (CTH) in acute renal IRI using CTH-deficient (Cth(-/-)) mice whose renal H2S levels were approximately 50% of control (..
  50. Penadés R, Pujol N, Catalán R, Masana G, García Rizo C, Bargalló N, et al. Cortical thickness in regions of frontal and temporal lobes is associated with responsiveness to cognitive remediation therapy in schizophrenia. Schizophr Res. 2016;171:110-6 pubmed publisher
    ..determine whether improvement in cognition following CRT is positively associated with baseline cortical thickness (CTh) or baseline clinical symptoms level or baseline cognitive performance...
  51. Multani J, Oermann E, Titano J, Mascitelli J, Nicol K, Feng R, et al. Quantitative Computed Tomography Ventriculography for Assessment and Monitoring of Hydrocephalus: A Pilot Study and Description of Method in Subarachnoid Hemorrhage. World Neurosurg. 2017;104:136-141 pubmed publisher
    ..Ten patients with normal head computed tomography (CTH) findings were analyzed as negative controls...
  52. Chen J, Lin I, Zhang H, Lin J, Zheng S, Fan M, et al. Reduced cortical thickness, surface area in patients with chronic obstructive pulmonary disease: a surface-based morphometry and neuropsychological study. Brain Imaging Behav. 2016;10:464-76 pubmed publisher
    ..Here we decomposed the cortical architecture into cortical thickness (CTh), surface area (SA), and gyrification, for the first time, to provide a more integrative profile of brain damage in ..
  53. Pellicano C, Niccolini F, Wu K, O Sullivan S, Lawrence A, Lees A, et al. Morphometric changes in the reward system of Parkinson's disease patients with impulse control disorders. J Neurol. 2015;262:2653-61 pubmed publisher
    ..Cortical thickness (CTh) and subcortical nuclei volume analyses were carried out using the automated surface-based analysis package ..
  54. Gutierrez Jimenez E, Cai C, Mikkelsen I, Rasmussen P, Angleys H, Merrild M, et al. Effect of electrical forepaw stimulation on capillary transit-time heterogeneity (CTH). J Cereb Blood Flow Metab. 2016;36:2072-2086 pubmed
    ..Our findings support the important role of capillary transit-time heterogeneity in flow-metabolism coupling during functional activation. ..
  55. Leisy H, Rastogi A, Guevara G, Ahmad M, Smith R. The association of geographic atrophy and decreased renal function in patients with age-related macular degeneration. Eye (Lond). 2017;31:62-67 pubmed publisher
    ..presence of GA, area of GA, drusen, and subretinal drusenoid deposits (SDD) and for subfoveal choroidal thickness (CTh) by standard criteria. Imaging findings were correlated with the most recent GFR from the patient's chart...
  56. Liu D, Xu S, Hu H, Pan J, Li P, Shen W. Endogenous Hydrogen Sulfide Homeostasis Is Responsible for the Alleviation of Senescence of Postharvest Daylily Flower via Increasing Antioxidant Capacity and Maintained Energy Status. J Agric Food Chem. 2017;65:718-726 pubmed publisher
    ..The activities of two important synthetic enzymes of H2S, l- and d-cysteine desulfhydrase, exhibited decreasing tendencies...
  57. Cui X, Navneet S, Wang J, Roon P, Chen W, Xian M, et al. Analysis of MTHFR, CBS, Glutathione, Taurine, and Hydrogen Sulfide Levels in Retinas of Hyperhomocysteinemic Mice. Invest Ophthalmol Vis Sci. 2017;58:1954-1963 pubmed publisher
    ..were analyzed for methylene tetrahydrofolate reductase (MTHFR), cystathionine-?-synthase (CBS), and cystathionase (CTH) RNA/protein levels...
  58. Renga B, Mencarelli A, Migliorati M, Distrutti E, Fiorucci S. Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation. World J Gastroenterol. 2009;15:2097-108 pubmed
    ..These results demonstrate that CSE is an FXR-regulated gene and provide a new molecular explanation for the pathophysiology of portal hypertension. ..
  59. Yang G, Pei Y, Teng H, Cao Q, Wang R. Specificity protein-1 as a critical regulator of human cystathionine gamma-lyase in smooth muscle cells. J Biol Chem. 2011;286:26450-60 pubmed publisher
    ..These results suggest that transcript factor Sp1 is a critical regulator of the hCSE expression during SMC differentiation, and CSE/H(2)S system is essential for maintenance of SMC phenotype. ..
  60. Yin P, Zhao C, Li Z, Mei C, Yao W, Liu Y, et al. Sp1 is involved in regulation of cystathionine ?-lyase gene expression and biological function by PI3K/Akt pathway in human hepatocellular carcinoma cell lines. Cell Signal. 2012;24:1229-40 pubmed publisher
    ..In summary, we have, for the first time, demonstrated that PI3K/Akt pathway regulates the CSE expression via Sp1, which is particularly important to understand the effect of PI3K/Akt and CSE on the tumorigenesis. ..
  61. Jurkowska H, Kaczor Kamińska M, Bronowicka Adamska P, Wróbel M. [Cystathionine γ-lyase]. Postepy Hig Med Dosw (Online). 2014;68:1-9 pubmed publisher
    Cystathionase (CTH, EC: 4.4.1...
  62. Fan K, Li N, Qi J, Yin P, Zhao C, Wang L, et al. Wnt/β-catenin signaling induces the transcription of cystathionine-γ-lyase, a stimulator of tumor in colon cancer. Cell Signal. 2014;26:2801-8 pubmed publisher
    ..In conclusion, we have demonstrated that the Wnt pathway regulates CSE gene expression on transcriptional level and CSE/H2S plays important roles in colon cancer. ..
  63. Panza E, De Cicco P, Armogida C, Scognamiglio G, Gigantino V, Botti G, et al. Role of the cystathionine γ lyase/hydrogen sulfide pathway in human melanoma progression. Pigment Cell Melanoma Res. 2015;28:61-72 pubmed publisher
    ..In fact, either l-cysteine, the CSE substrate, or DATS inhibited tumor growth in mice. In conclusion, we have determined that the l-cysteine/CSE/H2 S pathway is involved in melanoma progression. ..
  64. Ji Y, Bowersock A, Badour A, Vij N, Juris S, Ash D, et al. Dichotomous effects of isomeric secondary amines containing an aromatic nitrile and nitro group on human aortic smooth muscle cells via inhibition of cystathionine-?-lyase. Biochimie. 2017;133:103-111 pubmed publisher
    ..5 mM). Our findings suggest that these two families of amines inhibit cystathionine-?-lyase (CSE) to varying extents, which directly results in altered levels of intracellular HCY and consequent changes in HASMC proliferation. ..
  65. Manzouri A, Savic I. Cerebral sex dimorphism and sexual orientation. Hum Brain Mapp. 2017;: pubmed publisher
    ..Measurements of cortical thickness (Cth), subcortical volumes, and functional and structural resting-state connections among 40 heterosexual males (HeM) ..
  66. Lu Y, O Dowd B, Orrego H, Israel Y. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase. Biochem Biophys Res Commun. 1992;189:749-58 pubmed
    ..The two forms of human cystathionase deduced from the two cDNA clones may be derived from two different genes or may be splice variants. ..
  67. Wang J, Huff A, Spence J, Hegele R. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration. Clin Genet. 2004;65:483-6 pubmed
    ..Recently, we discovered that cystathioninuria was caused by mutations in the CTH gene encoding cystathionine gamma-lyase, an enzyme that converts cystathionine to cysteine in the trans-sulfuration ..
  68. Moore L, Malats N, Rothman N, Real F, Kogevinas M, Karami S, et al. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer. Int J Cancer. 2007;120:2452-8 pubmed
    ..evaluated associations between bladder cancer risk and 33 single nucleotide polymorphisms (SNPs) in 8 genes (CBS, CTH, MTHFR, MTR, MTRR, SHMT1, SLC19A1 and TYMS) and interactions with dietary variables involved in this pathway...
  69. Zhu W, Lin A, Banerjee R. Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase. Biochemistry. 2008;47:6226-32 pubmed publisher
    ..These results reveal that both mutations weaken the affinity for PLP and suggest that cystathionuric patients with these mutations should be responsive to pyridoxine therapy. ..
  70. Li Y, Zhao Q, Liu X, Wang L, Lu X, Li H, et al. Relationship between cystathionine gamma-lyase gene polymorphism and essential hypertension in Northern Chinese Han population. Chin Med J (Engl). 2008;121:716-20 pubmed
    ..Up to now, the reports on the relationship between the polymorphisms of cystathionine gamma-lyase gene (CTH) and essential hypertension (EH) are limited. This study was designed to assess their underlying relationship...
  71. Hua W, Jiang J, Rong X, Wu R, Qiu H, Zhang Y, et al. [Expression of cystathionine-?-lyase/hydrogen sulfide pathway in CVB3-induced myocarditis in mice]. Zhongguo Dang Dai Er Ke Za Zhi. 2010;12:744-8 pubmed
    ..05). CSE and its downstream production H2S increase in mice with acute viral myocarditis. The increased expression of CSE/H2S pathway might be involved in the pathogenesis of viral myocarditis. ..
  72. Laanpere M, Altmäe S, Kaart T, Stavreus Evers A, Nilsson T, Salumets A. Folate-metabolizing gene variants and pregnancy outcome of IVF. Reprod Biomed Online. 2011;22:603-14 pubmed publisher
    ..Heterozygosity for FOLR1 1816 C/delC and 1841 G/A was associated with a raised risk of pregnancy loss. The CTH 1208 GT genotype was associated with an increased chance of pregnancy and a smaller number of previously failed IVF ..
  73. Chung S, Low S, Zembutsu H, Takahashi A, Kubo M, Sasa M, et al. A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Breast Cancer Res. 2013;15:R81 pubmed
  74. Wang M, Guo Z, Wang S. The binding site for the transcription factor, NF-?B, on the cystathionine ?-lyase promoter is critical for LPS-induced cystathionine ?-lyase expression. Int J Mol Med. 2014;34:639-45 pubmed publisher
    ..Taken together, our data suggest that the NF-?B binding site on CSE promoter is critical for LPS-induced CSE expression in mammalian cells. ..
  75. Badiei A, Gieseg S, Davies S, Izani Othman M, Bhatia M. LPS Up-Regulates Cystathionine γ -Lyase Gene Expression in Primary Human Macrophages via NF-κB/ERK Pathway. Inflamm Allergy Drug Targets. 2015;14:99-104 pubmed
    ..Inhibition of NF-κB and ERK prevented the effect of LPS on H2S synthesizing activity in human primary macrophages. These data showed that H2S acts as an inflammatory mediator via NF-κB/ERK pathway in macrophages. ..
  76. Tromberg B, Zhang Z, Leproux A, O Sullivan T, Cerussi A, Carpenter P, et al. Predicting Responses to Neoadjuvant Chemotherapy in Breast Cancer: ACRIN 6691 Trial of Diffuse Optical Spectroscopic Imaging. Cancer Res. 2016;76:5933-5944 pubmed
    ..DOSI images of the tissue concentrations of deoxy-hemoglobin (ctHHb), oxy-hemoglobin (ctHbO2), water (ctH2O), lipid, and TOI (ctHHb × ctH2O/lipid) were acquired on both breasts up to four times ..
  77. Yang G, Cao K, Wu L, Wang R. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1. J Biol Chem. 2004;279:49199-205 pubmed
    ..Moreover, exogenous H2S induced a sustained ERK and p21Cip/WAK-1 activation. These findings support the hypothesis that endogenously produced H2S may play a fundamental role in cell proliferation and survival. ..
  78. Majtan T, Singh L, Wang L, Kruger W, Kraus J. Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone. J Biol Chem. 2008;283:34588-95 pubmed publisher
  79. Jurkowska H, Placha W, Nagahara N, Wróbel M. The expression and activity of cystathionine-?-lyase and 3-mercaptopyruvate sulfurtransferase in human neoplastic cell lines. Amino Acids. 2011;41:151-8 pubmed publisher
    ..Further investigations could aim at verifying whether the stimulation of CST, at the level of protein or gene expression, could change the proliferation of neoplastic cells. ..
  80. Wang M, Guo Z, Wang S. Regulation of cystathionine ?-lyase in mammalian cells by hypoxia. Biochem Genet. 2014;52:29-37 pubmed publisher
    ..Therefore, the up-regulation of CSE expression during hypoxia may be useful for increasing the production and concentration of H2S in mammalian cells and indirectly protecting cells from hypoxia. ..
  81. Pan Y, Ye S, Yuan D, Zhang J, Bai Y, Shao C. Hydrogen sulfide (H2S)/cystathionine ?-lyase (CSE) pathway contributes to the proliferation of hepatoma cells. Mutat Res. 2014;763-764:10-8 pubmed publisher
  82. Paul B, Snyder S. Neurodegeneration in Huntington's disease involves loss of cystathionine ?-lyase. Cell Cycle. 2014;13:2491-3 pubmed publisher
  83. Gong D, Cheng H, Xie W, Zhang M, Liu D, Lan G, et al. Cystathionine ?-lyase(CSE)/hydrogen sulfide system is regulated by miR-216a and influences cholesterol efflux in macrophages via the PI3K/AKT/ABCA1 pathway. Biochem Biophys Res Commun. 2016;470:107-116 pubmed publisher
    ..Our study demonstrates that CSE/H2S system is regulated by miR-216a, and regulates ABCA1-mediated cholesterol efflux and cholesterol levels through the PI3K/AKT pathway. ..
  84. Sun Q, Collins R, Huang S, Holmberg Schiavone L, Anand G, Tan C, et al. Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S. J Biol Chem. 2009;284:3076-85 pubmed publisher
    ..These results provide significant insights, which will facilitate the structure-based design of novel inhibitors of hCSE to aid in the development of therapies for diseases involving disorders of sulfur metabolism. ..
  85. Altmäe S, Stavreus Evers A, Ruiz J, Laanpere M, Syvänen T, Yngve A, et al. Variations in folate pathway genes are associated with unexplained female infertility. Fertil Steril. 2010;94:130-7 pubmed publisher
    ..To investigate associations between folate-metabolizing gene variations, folate status, and unexplained female infertility...
  86. Kondo K, Bhushan S, King A, Prabhu S, Hamid T, Koenig S, et al. H?S protects against pressure overload-induced heart failure via upregulation of endothelial nitric oxide synthase. Circulation. 2013;127:1116-27 pubmed publisher
  87. Wang K, Ahmad S, Cai M, Rennie J, Fujisawa T, Crispi F, et al. Dysregulation of hydrogen sulfide producing enzyme cystathionine ?-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia. Circulation. 2013;127:2514-22 pubmed publisher
    ..We hypothesized that a reduction in CSE activity may alter the angiogenic balance in pregnancy and induce abnormal placentation and maternal hypertension...
  88. Zhao K, Li H, Li S, Yang G. Regulation of cystathionine gamma-lyase/H?S system and its pathological implication. Front Biosci (Landmark Ed). 2014;19:1355-69 pubmed
    ..As such, our understanding of the pathogenesis of human diseases will be better achieved and the corresponding new therapy can be devised. ..
  89. Shen Y, Shen Z, Miao L, Xin X, Lin S, Zhu Y, et al. miRNA-30 family inhibition protects against cardiac ischemic injury by regulating cystathionine-γ-lyase expression. Antioxid Redox Signal. 2015;22:224-40 pubmed publisher
  90. Yao Y, Zhang X, Chen H, Li L, Xie W, Lan G, et al. MicroRNA-186 promotes macrophage lipid accumulation and secretion of pro-inflammatory cytokines by targeting cystathionine ?-lyase in THP-1 macrophages. Atherosclerosis. 2016;250:122-32 pubmed publisher
    ..MicroRNA-186 promotes macrophage lipid accumulation and pro-inflammatory cytokine secretion by targeting cystathionine ?-lyase in THP-1 macrophages. ..
  91. Wang J, Hegele R. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH). Hum Genet. 2003;112:404-8 pubmed
    ..MIM 219500) is presumed to be caused by deficiency of the activity of cystathionine gamma-lyase (cystathionase; CTH EC, which is normally required for the conversion of methionine into cysteine...
  92. Kraus J, Hasek J, Kozich V, Collard R, Venezia S, Janosíková B, et al. Cystathionine gamma-lyase: Clinical, metabolic, genetic, and structural studies. Mol Genet Metab. 2009;97:250-9 pubmed publisher
    We report studies of six individuals with marked elevations of cystathionine in plasma and/or urine. Studies of CTH, the gene that encodes cystathionine gamma-lyase, revealed the presence among these individuals of either homozygous or ..