Gene Symbol: CTDNEP1
Description: CTD nuclear envelope phosphatase 1
Alias: DULLARD, HSA011916, NET56, CTD nuclear envelope phosphatase 1, C-terminal domain nuclear envelope phosphatase 1, dullard homolog, serine/threonine-protein phosphatase dullard
Naderi M, Pazouki A, Arefian E, Hashemi S, Jamshidi Adegani F, Gholamalamdari O, et al
. Two Triacylglycerol Pathway Genes, CTDNEP1 and LPIN1, are Down-Regulated by hsa-miR-122-5p in Hepatocytes. Arch Iran Med. 2017;20:165-171 pubmed publisher
..A systematic computational analysis of putative targets of miR-122 identified CTDNEP1 and LPIN1 genes in the TAG pathway...
Satow R, Kurisaki A, Chan T, Hamazaki T, Asashima M. Dullard promotes degradation and dephosphorylation of BMP receptors and is required for neural induction. Dev Cell. 2006;11:763-74 pubmed
..In Xenopus development, inhibition of the BMP pathway is essential for neural induction. Here, we report that dullard, a gene involved in neural development, functions as a negative regulator of BMP signaling...
Kim Y, Gentry M, Harris T, Wiley S, Lawrence J, Dixon J. A conserved phosphatase cascade that regulates nuclear membrane biogenesis. Proc Natl Acad Sci U S A. 2007;104:6596-601 pubmed
..A member of this DXDX(T/V) phosphatase family known as Dullard was recently shown to be a potential regulator of neural tube development in Xenopus [Satow R, Chan TC, Asashima ..
Han S, Bahmanyar S, Zhang P, Grishin N, Oegema K, Crooke R, et al
. Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway. J Biol Chem. 2012;287:3123-37 pubmed publisher
..A mammalian ortholog of Nem1p is the C-terminal domain nuclear envelope phosphatase 1 (CTDNEP1, formerly "dullard"), but its Spo7p-like partner is unknown, and the need for its existence is debated...
Rajasekharan S, Kumar K, Rana J, Gupta A, Chaudhary V, Gupta S. Host interactions of Chandipura virus matrix protein. Acta Trop. 2015;149:27-31 pubmed publisher
..The study identified novel human host interactors for CHPV which concurred with previously described associations in other human viruses. ..
Satow R, Chan T, Asashima M. Molecular cloning and characterization of dullard: a novel gene required for neural development. Biochem Biophys Res Commun. 2002;295:85-91 pubmed
In a screen for genes expressed in neural tissues and pronephroi, we isolated a novel gene, named dullard. Dullard protein contains the C-terminal conserved domain of NLI-IF (Nuclear LIM Interactor-Interacting Factor), a protein whose ..
Zhang Y, Kim Y, Genoud N, Gao J, Kelly J, Pfaff S, et al
. Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol Cell. 2006;24:759-770 pubmed publisher
..Ser5 of the CTD heptad repeat. Moreover, these results provide a template for the design of specific inhibitors of Scp1 for the study of neuronal stem cell development. ..
Wu R, Garland M, Dunaway Mariano D, Allen K. Homo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1. Biochemistry. 2011;50:3045-7 pubmed publisher
..function are directed by phosphorylation-dephosphorylation events catalyzed by the phosphoserine phosphatase dullard. To define the determinants of dullard substrate recognition and catalysis, and hence, lipin regulation, steady-..