CSK

Summary

Gene Symbol: CSK
Description: C-terminal Src kinase
Alias: tyrosine-protein kinase CSK, C-Src kinase, CSK, non-receptor tyrosine kinase, c-src tyrosine kinase, protein-tyrosine kinase CYL
Species: human
Products:     CSK

Top Publications

  1. Borchert T, Mathieu M, Zeelen J, Courtneidge S, Wierenga R. The crystal structure of human CskSH3: structural diversity near the RT-Src and n-Src loop. FEBS Lett. 1994;341:79-85 pubmed
    ..The crystal structure of the SH3 domain of Csk (c-Src specific tyrosine kinase) has been refined at a resolution of 2.5 A, with an R-factor of 22.4%...
  2. Bergman M, Joukov V, Virtanen I, Alitalo K. Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreading. Mol Cell Biol. 1995;15:711-22 pubmed
    ..To gain insight into the cellular functions of this potentially antioncogenic enzyme, we have overexpressed the csk cDNA by using an inducible promoter in HeLa cells...
  3. Wang B, Lemay S, Tsai S, Veillette A. SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. Mol Cell Biol. 2001;21:1077-88 pubmed
    The protein tyrosine kinase (PTK) Csk is a potent negative regulator of several signal transduction processes, as a consequence of its exquisite ability to inactivate Src-related PTKs...
  4. Taylor S, Shalloway D. An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis. Nature. 1994;368:867-71 pubmed
    ..Because the Src SH3 domain also binds heterogeneous nuclear ribonucleoprotein K, these results raise the intriguing possibility that c-Src may regulate the processing, trafficking or translation of RNA in a cell-cycle-dependent manner. ..
  5. Neet K, Hunter T. The nonreceptor protein-tyrosine kinase CSK complexes directly with the GTPase-activating protein-associated p62 protein in cells expressing v-Src or activated c-Src. Mol Cell Biol. 1995;15:4908-20 pubmed
    b>CSK is a predominantly cytosolic protein-tyrosine kinase (PTK) that negatively regulates Src family PTKs by phosphorylation of a conserved tyrosine near their C termini. Little is known about how CSK itself is regulated...
  6. Catipovic B, Schneck J, Brummet M, Marsh D, Rafnar T. Csk is constitutively associated with a 60-kDa tyrosine-phosphorylated protein in human T cells. J Biol Chem. 1996;271:9698-703 pubmed
    The protein-tyrosine kinase Csk is one of the main down-regulators of the Src family of kinases...
  7. Cloutier J, Veillette A. Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells. EMBO J. 1996;15:4909-18 pubmed
    p50csk is a tyrosine protein kinase (TPK) that represses the activity of Src family TPKs. We previously showed that Csk is a potent negative regulator of antigen receptor signaling in T lymphocytes and that its Src homology (SH) 3 and ..
  8. Gregorieff A, Cloutier J, Veillette A. Sequence requirements for association of protein-tyrosine phosphatase PEP with the Src homology 3 domain of inhibitory tyrosine protein kinase p50(csk). J Biol Chem. 1998;273:13217-22 pubmed
    Previously, we reported that the inhibitory tyrosine protein kinase p50(csk) is physically associated with the protein-tyrosine phosphatase PEP in hematopoietic cells...
  9. Arbet Engels C, Tartare Deckert S, Eckhart W. C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor. J Biol Chem. 1999;274:5422-8 pubmed
    ..We observed that the IGF-IR and IR associated with the C-terminal Src kinase (CSK) following ligand stimulation...

More Information

Publications101 found, 100 shown here

  1. Brdicka T, Pavlistová D, Leo A, Bruyns E, Korinek V, Angelisova P, et al. Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. J Exp Med. 2000;191:1591-604 pubmed
    ..tyrosine-phosphorylated protein and binds the major negative regulator of Src kinases, the tyrosine kinase Csk. After activation of peripheral blood alpha/beta T cells, PAG becomes rapidly dephosphorylated and dissociates from ..
  2. Kawabuchi M, Satomi Y, Takao T, Shimonishi Y, Nada S, Nagai K, et al. Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases. Nature. 2000;404:999-1003 pubmed
    ..The activity of Src-PTKs in cells of different types is negatively controlled by Csk, which specifically phosphorylates a conserved regulatory tyrosine residue at the carboxy-terminal tail of the Src-..
  3. Pfrepper K, Marie Cardine A, Simeoni L, Kuramitsu Y, Leo A, Spicka J, et al. Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein). Eur J Immunol. 2001;31:1825-36 pubmed
    ..Co-precipitation experiments revealed that the tyrosine kinase p50(csk) could represent the negative regulatory effector molecule that binds to this motif.
  4. Perez Y, Gairi M, Pons M, Bernado P. Structural characterization of the natively unfolded N-terminal domain of human c-Src kinase: insights into the role of phosphorylation of the unique domain. J Mol Biol. 2009;391:136-48 pubmed publisher
    ..These observations suggest the unique domain of Src kinases as a source of selectivity and reinforce the relevant role of intrinsically disordered proteins in biological processes. ..
  5. Autero M, Saharinen J, Pessa Morikawa T, Soula Rothhut M, Oetken C, Gassmann M, et al. Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase. Mol Cell Biol. 1994;14:1308-21 pubmed
    ..Cotransfection of CD45 and csk into COS-1 cells caused tyrosine phosphorylation of CD45 in the intact cells...
  6. Sabe H, Hata A, Okada M, Nakagawa H, Hanafusa H. Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src. Proc Natl Acad Sci U S A. 1994;91:3984-8 pubmed
    b>Csk (C-terminal Src kinase), a protein-tyrosine kinase, bearing the Src homology 2 and 3 (SH2 and SH3) domains, has been implicated in phosphorylation of c-Src Tyr-527, resulting in suppression of c-Src kinase activity...
  7. Wilson G, Cramer A, Welman A, Knox F, Swindell R, Kawakatsu H, et al. Activated c-SRC in ductal carcinoma in situ correlates with high tumour grade, high proliferation and HER2 positivity. Br J Cancer. 2006;95:1410-4 pubmed
    ..011). Thus, high c-Src activity may identify a subset of DCIS with high risk of recurrence or progression to invasive cancer where therapeutics targeting c-Src may benefit this patient subset. ..
  8. Di Stefano P, Damiano L, Cabodi S, Aramu S, Tordella L, Praduroux A, et al. p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity. EMBO J. 2007;26:2843-55 pubmed
    ..we characterise p140Cap as a novel Src-binding protein, which regulates Src activation via C-terminal Src kinase (Csk). p140Cap silencing increases cell spreading, migration rate and Src kinase activity...
  9. Martin J, Broen J, Carmona F, Teruel M, Simeon C, Vonk M, et al. Identification of CSK as a systemic sclerosis genetic risk factor through Genome Wide Association Study follow-up. Hum Mol Genet. 2012;21:2825-35 pubmed publisher
    ..We found evidence for replication and overall genome-wide significance for one novel SSc genetic risk locus: CSK [P-value = 5.04 × 10(-12), odds ratio (OR) = 1.20]...
  10. Serrano A, Márquez A, Mackie S, Carmona F, Solans R, Miranda Filloy J, et al. Identification of the PTPN22 functional variant R620W as susceptibility genetic factor for giant cell arteritis. Ann Rheum Dis. 2013;72:1882-1886 pubmed publisher
    To analyse the role of the PTPN22 and CSK genes, previously associated with autoimmunity, in the predisposition and clinical phenotypes of giant cell arteritis (GCA)...
  11. Partanen J, Armstrong E, Bergman M, Mäkelä T, Hirvonen H, Huebner K, et al. cyl encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416src). Oncogene. 1991;6:2013-8 pubmed
    ..The cyl gene is located on human chromosome 15. It is expressed ubiquitously as two independently regulated mRNA species of 2.6 and 3.4 kb in human leukemia cell lines and fetal tissues. ..
  12. Takeuchi S, Takayama Y, Ogawa A, Tamura K, Okada M. Transmembrane phosphoprotein Cbp positively regulates the activity of the carboxyl-terminal Src kinase, Csk. J Biol Chem. 2000;275:29183-6 pubmed
    b>Csk (carboxyl-terminal Src kinase) is a cytoplasmic tyrosine kinase that phosphorylates a critical tyrosine residue in each of the Src family kinases (SFKs) to inhibit their activities...
  13. Ghose R, Shekhtman A, Goger M, Ji H, Cowburn D. A novel, specific interaction involving the Csk SH3 domain and its natural ligand. Nat Struct Biol. 2001;8:998-1004 pubmed
    C-terminal Src kinase (Csk) takes part in a highly specific, high affinity interaction via its Src homology 3 (SH3) domain with the proline-enriched tyrosine phosphatase PEP in hematopoietic cells...
  14. Cao H, Courchesne W, Mastick C. A phosphotyrosine-dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of C-terminal Src kinase. J Biol Chem. 2002;277:8771-4 pubmed
    ..manner: tumor necrosis factor-alpha receptor-associated factor 2 (TRAF2) and C-terminal Src kinase (Csk). TRAF2 bound to nonphosphorylated caveolin-1, but this association was increased 3-fold by phosphorylation...
  15. Ostareck Lederer A, Ostareck D, Cans C, Neubauer G, Bomsztyk K, Superti Furga G, et al. c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs. Mol Cell Biol. 2002;22:4535-43 pubmed
    ..Our results establish a novel role of c-Src kinase in translational gene regulation and reveal a mechanism by which silenced mRNAs can be translationally activated. ..
  16. Wong L, Lieser S, Miyashita O, Miller M, Tasken K, Onuchic J, et al. Coupled motions in the SH2 and kinase domains of Csk control Src phosphorylation. J Mol Biol. 2005;351:131-43 pubmed
    The C-terminal Src kinase (Csk) phosphorylates and down-regulates Src family tyrosine kinases. The Csk-binding protein (Cbp) localizes Csk close to its substrates at the plasma membrane, and increases the specific activity of the kinase...
  17. Levinson N, Seeliger M, Cole P, Kuriyan J. Structural basis for the recognition of c-Src by its inactivator Csk. Cell. 2008;134:124-34 pubmed publisher
    ..on a tyrosine residue located near the C terminus (Tyr 527 in c-Src), which is catalyzed by C-terminal Src Kinase (Csk)...
  18. Manjarrez Orduno N, Marasco E, Chung S, Katz M, Kiridly J, Simpfendorfer K, et al. CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation. Nat Genet. 2012;44:1227-30 pubmed publisher
    The c-Src tyrosine kinase, Csk, physically interacts with the intracellular phosphatase Lyp (encoded by PTPN22) and can modify the activation state of downstream Src kinases, such as Lyn, in lymphocytes...
  19. Tawadros P, Powers K, Ailenberg M, Birch S, Marshall J, Szaszi K, et al. Oxidative Stress Increases Surface Toll-Like Receptor 4 Expression in Murine Macrophages Via Ceramide Generation. Shock. 2015;44:157-65 pubmed publisher
    ..inhibition of the Src family kinases by PP2, Src inhibition by a molecular approach of cell transfection with Csk, and genetic inhibition of all Src kinases relevant to the monocyte/macrophage lineage in hckfgrlyn triple knockout ..
  20. Facci L, Barbierato M, Zusso M, Skaper S, Giusti P. Serum amyloid A primes microglia for ATP-dependent interleukin-1β release. J Neuroinflammation. 2018;15:164 pubmed publisher
    ..the TLR2 antagonist CU-CPT22 was inactive against Apo-SAA, it also failed to block the TLR2 agonist Pam3CSK4. Microglia are central to the inflammatory process and a major source of IL-1β when activated...
  21. Mishra J, Cohen D, Zamperone A, Nesic D, MUESCH A, Stein M. CagA of Helicobacter pylori interacts with and inhibits the serine-threonine kinase PRK2. Cell Microbiol. 2015;17:1670-82 pubmed publisher
    ..Additionally, CagA was described to affect the activity of Src family kinases and C-terminal Src kinase (Csk) suggesting that interference with multiple cellular kinase- and phosphatase-associated signalling pathways is a ..
  22. Tegtmeyer N, Neddermann M, Asche C, Backert S. Subversion of host kinases: a key network in cellular signaling hijacked by Helicobacter pylori CagA. Mol Microbiol. 2017;105:358-372 pubmed publisher
    ..transmission by translocated CagA on multiple receptor kinases (c-Met and EGFR) and non-receptor kinases (Src, Abl, Csk, aPKC, Par1, PI3K, Akt, FAK, GSK-3, JAK, PAK1, PAK2 and MAP kinases), manipulating a selection of fundamental ..
  23. Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Fischer S, Rodriguez V, et al. GATA4 Regulates Blood-Testis Barrier Function and Lactate Metabolism in Mouse Sertoli Cells. Endocrinology. 2016;157:2416-31 pubmed publisher
    ..involved in key facets of BTB maintenance, including tight/adherens junction formation (Tjp1, Cldn12, Vcl, Tnc, Csk) and extracellular matrix reorganization (Lamc1, Col4a1, Col4a5, Mmp10, Mmp23, Timp2)...
  24. Xu L, Tong X, Zhang S, Yin F, Li X, Wei H, et al. ASPP2 suppresses stem cell-like characteristics and chemoresistance by inhibiting the Src/FAK/Snail axis in hepatocellular carcinoma. Tumour Biol. 2016;37:13669-13677 pubmed
    ..ASPP2 does this by physically interacting with C-terminal Src kinase (CSK) and stimulating its kinase activity, which eventually leads to activator protein 1 (AP1)-mediated downregulation ..
  25. Yamamoto S, Ogasawara N, Yamamoto K, Uemura C, Takaya Y, Shiraishi T, et al. Mitochondrial proteins NIP-SNAP-1 and -2 are a target for the immunomodulatory activity of clarithromycin, which involves NF-?B-mediated cytokine production. Biochem Biophys Res Commun. 2017;483:911-916 pubmed publisher
    ..Production of proinflammatory cytokines (IL-8 and IL-6) induced by lipopolysaccharides (LPSs) and Pam3-CSK4 in human epithelial cell lines BEAS-2B and T24 were suppressed by knockdown of NIP-SNAP-1 or -2, and ..
  26. Joukov V, Vihinen M, Vainikka S, Sowadski J, Alitalo K, Bergman M. Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure. Biochem J. 1997;322 ( Pt 3):927-35 pubmed
    The lack of a conserved tyrosine autophosphorylation site is a unique feature of the C-terminal Src-kinase, Csk, although this protein tyrosine kinase can be autophosphorylated on tyrosine residues in vitro and in bacteria...
  27. Cayabyab F, Schlichter L. Regulation of an ERG K+ current by Src tyrosine kinase. J Biol Chem. 2002;277:13673-81 pubmed
    ..Thus, r-ERG1 and Src tyrosine kinase appear to exist in a signaling complex that is well positioned to modulate this K(+) channel and affect its contribution to cellular functions. ..
  28. Zhou J, Scholes J, Hsieh J. Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer. J Biol Chem. 2003;278:6936-41 pubmed
    ..It appears that DOC-2/DAB2 can bind to Src homology 3 domain of c-Src and maintain it in an inactive conformation. Thus, this study provides a new mechanism for modulating c-Src in prostatic epithelium and cancer. ..
  29. Rafalska I, Zhang Z, Benderska N, Wolff H, Hartmann A, Brack Werner R, et al. The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation. Hum Mol Genet. 2004;13:1535-49 pubmed
    ..We propose that tyrosine phosphorylation causes sequestration of YT521-B in an insoluble nuclear form, which abolishes the ability of YT521-B to change alternative splice sites. ..
  30. Mills J, Whitford P, Shaffer J, Onuchic J, Adams J, Jennings P. A novel disulfide bond in the SH2 Domain of the C-terminal Src kinase controls catalytic activity. J Mol Biol. 2007;365:1460-8 pubmed
    The SH2 domain of the C-terminal Src kinase [Csk] contains a unique disulfide bond that is not present in other known SH2 domains...
  31. Radziwill G, Weiss A, Heinrich J, Baumgartner M, Boisguerin P, Owada K, et al. Regulation of c-Src by binding to the PDZ domain of AF-6. EMBO J. 2007;26:2633-44 pubmed
    ..Unphosphorylated Tyr527 allows binding of c-Src to AF-6. This can be overcome by overexpression of CSK or strong activation of c-Src...
  32. Wallis A, Wallace E, Hostager B, Yi Z, Houtman J, Bishop G. TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22. Sci Rep. 2017;7:2081 pubmed publisher
    ..event led to the hypothesis that TRAF3 restrains one or both of two known inhibitors of Lck, C-terminal Src kinase (Csk) and protein tyrosine phosphatase N22 (PTPN22)...
  33. Tong K, Wang Y, Su Z. Phosphotyrosine signalling and the origin of animal multicellularity. Proc Biol Sci. 2017;284: pubmed publisher
    ..origin of many key features of metazoan pTyr signalling, and the metazoan establishment of others, including the Csk-mediated negative regulation of the activity of Src, a conserved tyrosine kinase in the Holozoa...
  34. Cai H, Orwenyo J, Giddens J, Yang Q, Zhang R, LaBranche C, et al. Synthetic Three-Component HIV-1 V3 Glycopeptide Immunogens Induce Glycan-Dependent Antibody Responses. Cell Chem Biol. 2017;24:1513-1522.e4 pubmed publisher
    ..consists of a 33-mer V3 glycopeptide epitope, a universal T helper epitope P30, and a lipopeptide (Pam3CSK4) that serves as a ligand of Toll-like receptor 2...
  35. Mustelin T, Tasken K. Positive and negative regulation of T-cell activation through kinases and phosphatases. Biochem J. 2003;371:15-27 pubmed
    ..Proximal signalling pathways involve PTKs of the Src, Syk, Csk and Tec families, adapter proteins and effector enzymes in a highly organized tyrosine-phosphorylation cascade...
  36. Ren Y, Meng S, Mei L, Zhao Z, Jove R, Wu J. Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor. J Biol Chem. 2004;279:8497-505 pubmed
    ..SHP2 dephosphorylated paxillin and caused dissociation of Csk, a negative regulator of Src, from paxillin but had no effect on paxillin-Src association...
  37. Longworth M, Laimins L. Histone deacetylase 3 localizes to the plasma membrane and is a substrate of Src. Oncogene. 2006;25:4495-500 pubmed
    ..Our results describe a novel localization and binding partner for the HDAC3 protein, as well as implicate c-Src in HDAC3 regulation. ..
  38. Weiss A, Baumgartner M, Radziwill G, Dennler J, Moelling K. c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1. FEBS Lett. 2007;581:5131-6 pubmed
    ..Furthermore, we show that c-Src phosphorylates LNX1. Moreover, c-Src itself is ubiquitinated by LNX1, suggesting an interdependent regulation of c-Src and LNX1. ..
  39. Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, et al. Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2. J Biol Chem. 2008;283:9177-86 pubmed publisher
    ..using rat glomerular lysates, Neph1 but not nephrin specifically binds to adaptor protein Grb2 and tyrosine kinase Csk in a phosphorylation-dependent manner. Both tyrosine 637 and 638 of Neph1 are crucial for Neph1-Grb2 binding...
  40. Sirvent A, Benistant C, Pannequin J, Veracini L, Simon V, Bourgaux J, et al. Src family tyrosine kinases-driven colon cancer cell invasion is induced by Csk membrane delocalization. Oncogene. 2010;29:1303-15 pubmed publisher
    ..we show that the SFK-dependent invasion is induced by inactivation of the negative regulator C-terminal Src kinase, Csk. While the level of Csk was inconsistent with SFK activity in colon cancer cells, its membrane translocation, ..
  41. Meng Y, Roux B. Locking the active conformation of c-Src kinase through the phosphorylation of the activation loop. J Mol Biol. 2014;426:423-35 pubmed publisher
    ..In summary, the free-energy landscape calculations demonstrate that phosphorylation of tyrosine 416 in the A-loop essentially "locks" the kinase into its catalytically competent conformation. ..
  42. Adam A, Lowery A, Martino N, Alsaffar H, Vincent P. Src Family Kinases Modulate the Loss of Endothelial Barrier Function in Response to TNF-α: Crosstalk with p38 Signaling. PLoS ONE. 2016;11:e0161975 pubmed publisher
    ..demonstrated that activation of endogenous SFKs by expression of dominant negative C-terminal Src Kinase (DN-Csk) is not sufficient to decrease endothelial adherens junction integrity...
  43. Mahendrarajah N, Borisova M, Reichardt S, Godmann M, Sellmer A, Mahboobi S, et al. HSP90 is necessary for the ACK1-dependent phosphorylation of STAT1 and STAT3. Cell Signal. 2017;39:9-17 pubmed publisher
    ..In addition to these molecular insights, our data offer a pharmacological strategy to control the ACK1-STAT signalling axis. ..
  44. Romaker D, Schregel V, Maurer K, Auerochs S, Marzi A, Sticht H, et al. Analysis of the structure-activity relationship of four herpesviral UL97 subfamily protein kinases reveals partial but not full functional conservation. J Med Chem. 2006;49:7044-53 pubmed
    ..Thus, the structure-activity analysis of pUL97-like herpesviral protein kinases indicates a partial but not a full conservation of their functional properties among the herpesviruses. ..
  45. Dai S, Abu Amer W, Karuppaiah K, Abu Amer Y. Evidence that the kinase-truncated c-Src regulates NF-?B signaling by targeting NEMO. J Cell Biochem. 2011;112:2463-70 pubmed publisher
    ..Buttressing these findings, the expression of NEMO and NF-?B signaling were significantly reduced in monocytes collected from Src251 transgenic mice. ..
  46. Yang C, Fazli L, Loguercio S, Zharkikh I, Aza Blanc P, Gleave M, et al. Downregulation of c-SRC kinase CSK promotes castration resistant prostate cancer and pinpoints a novel disease subclass. Oncotarget. 2015;6:22060-71 pubmed
    ..Performing a functional genomics screen, we found that downregulation of SRC inhibitory kinase CSK is sufficient to overcome growth arrest induced by depriving human prostate cancer cells of androgen...
  47. Ullah M, Ullah H, Murtaza G, Mahmood Q, Hussain I. Evaluation of Influence of Various Polymers on Dissolution and Phase Behavior of Carbamazepine-Succinic Acid Cocrystal in Matrix Tablets. Biomed Res Int. 2015;2015:870656 pubmed publisher
    ..direct relation was observed between percent drug release and polymer concentrations of Kollidon VA 64/Soluplus (CSK, CSS)...
  48. Sang W, Wang Y, Zhang C, Zhang D, Sun C, Niu M, et al. MiR-150 impairs inflammatory cytokine production by targeting ARRB-2 after blocking CD28/B7 costimulatory pathway. Immunol Lett. 2016;172:1-10 pubmed publisher
    ..trimer recruitment into the lipid raft by inhibiting the activities of PI3K and AKT through the cAMP-PKA-Csk signaling pathway...
  49. Park Y, Kwock C, Kim K, Kim J, Yang Y. Interaction between Single Nucleotide Polymorphism and Urinary Sodium, Potassium, and Sodium-Potassium Ratio on the Risk of Hypertension in Korean Adults. Nutrients. 2017;9: pubmed publisher
    ..b>CSK rs1378942 and CSK-MIR4513 rs3784789 were significantly modified by urinary sodium-potassium excretion ratio...
  50. Taskinen B, Ferrada E, Fowler D. Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase. J Biol Chem. 2017;292:18518-18529 pubmed publisher
    ..kinase Src is inhibited via phosphorylation of its C-terminal tail by another kinase, C-terminal Src kinase (Csk)...
  51. Miller W, Maudsley S, Ahn S, Khan K, Luttrell L, Lefkowitz R. beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. J Biol Chem. 2000;275:11312-9 pubmed
  52. Baranova L, Emelyanova V, Volotovski I. Role of the Yes and Csk tyrosine kinases in the development of a pathological state in the human retina. Mol Biol Rep. 2010;37:2727-33 pubmed publisher
    ..tyrosine kinases, the nucleotide sequences of which feature a high homology to the gene families of the Yes and Csk tyrosine kinases, and a cloning of the complete coding sequence of the cDNA of the Csk tyrosine kinase gene of the ..
  53. Shi C, Ma Y, Liu H, Zhang Y, Wang Z, Jia H. The non-receptor tyrosine kinase c-Src mediates the PDGF-induced association between Furin and pro-MT1-MMP in HPAC pancreatic cells. Mol Cell Biochem. 2012;362:65-70 pubmed publisher
    ..The SH2 domain appeared to be important for c-Src interaction with Furin. In addition, we showed that Furin protein is tyrosine phosphorylated. Association between Furin and MT1-MMP is regulated by the tyrosine kinase c-Src. ..
  54. Repetto D, Aramu S, Boeri Erba E, Sharma N, Grasso S, Russo I, et al. Mapping of p140Cap phosphorylation sites: the EPLYA and EGLYA motifs have a key role in tyrosine phosphorylation and Csk binding, and are substrates of the Abl kinase. PLoS ONE. 2013;8:e54931 pubmed publisher
    ..Moreover, this mutant lost its ability to bind the C-terminal Src kinase (Csk), previously shown to interact with p140Cap by Far Western analysis...
  55. Gregersen P, Klein G, Keogh M, Kern M, DeFranco M, Simpfendorfer K, et al. The Genotype and Phenotype (GaP) registry: a living biobank for the analysis of quantitative traits. Immunol Res. 2015;63:107-12 pubmed publisher
    ..The GaP has facilitated functional studies of several autoimmune disease associated loci including Csk, Blk, PDRM1 (Blimp-1) and PTPN22...
  56. Socodato R, Santiago F, Portugal C, Domith I, Encarnação T, Loiola E, et al. Dopamine promotes NMDA receptor hypofunction in the retina through D1 receptor-mediated Csk activation, Src inhibition and decrease of GluN2B phosphorylation. Sci Rep. 2017;7:40912 pubmed publisher
    ..the canonical D1R/adenylyl cyclase/cAMP/PKA pathway, of PKA-induced activation of C-terminal Src kinase (Csk) and of Src inhibition...
  57. Davidson L, Pawson A, Lopez de Maturana R, Freestone S, Barran P, Millar R, et al. Gonadotropin-releasing hormone-induced activation of diacylglycerol kinase-zeta and its association with active c-src. J Biol Chem. 2004;279:11906-16 pubmed
    ..Elevated expression of DGK-zeta resulted in a shortening of the time scale of ERK activation in these cells suggesting a potential role of endogenous DGK-zeta in controlling the induction of LHbeta transcription by ERK1/2. ..
  58. Della Mina E, Borghesi A, Zhou H, Bougarn S, Boughorbel S, Israel L, et al. Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblasts. Proc Natl Acad Sci U S A. 2017;114:E514-E523 pubmed publisher
    ..was completely absent from the patient's fibroblasts, which responded very poorly to all TLR2/6 (PAM2CSK4, LTA, FSL-1), TLR1/2 (PAM3CSK4), and TLR4 (LPS, MPLA) agonists tested but had ..
  59. Mikkola E, Bergman M. Conserved hydrophobicity in the SH2-kinase linker is required for catalytic activity of Csk and CHK. FEBS Lett. 2003;544:11-4 pubmed
    The crystal structure of full-length Csk (C-terminal Src kinase) molecules shows a hydrophobic interaction between the SH2-kinase linker residue Phe183 and the alphaC-helix of the catalytic domain...
  60. Jones R, Avizienyte E, Wyke A, Owens D, Brunton V, Frame M. Elevated c-Src is linked to altered cell-matrix adhesion rather than proliferation in KM12C human colorectal cancer cells. Br J Cancer. 2002;87:1128-35 pubmed
  61. Huang W, Chen J, Inoue H, Chen C. Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expression. J Immunol. 2003;170:4767-75 pubmed
    ..These two pathways cross-link between c-Src and NIK and converge at IKKalpha/beta, and go on to activate NF-kappaB, via serine phosphorylation and degradation of IkappaB-alpha, and, finally, to initiate COX-2 expression. ..
  62. Lee S, Lin X, Nam N, Parang K, Sun G. Determination of the substrate-docking site of protein tyrosine kinase C-terminal Src kinase. Proc Natl Acad Sci U S A. 2003;100:14707-12 pubmed
    ..However, a substrate-docking site has not been determined on any PTK. C-terminal Src kinase (Csk) is a PTK that specifically phosphorylates Src family kinases on a C-terminal Tyr...
  63. De Corte V, Demol H, Goethals M, Van Damme J, Gettemans J, Vandekerckhove J. Identification of Tyr438 as the major in vitro c-Src phosphorylation site in human gelsolin: a mass spectrometric approach. Protein Sci. 1999;8:234-41 pubmed
    ..Based on these results we generated antibodies which specifically recognize Tyr438 phosphorylated gelsolin. ..
  64. Sanjay A, Houghton A, Neff L, Didomenico E, Bardelay C, Antoine E, et al. Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility. J Cell Biol. 2001;152:181-95 pubmed
    ..These findings may explain the osteopetrotic phenotype in the Src(-/-) mice. ..
  65. Johnsen I, Nguyen T, Ringdal M, Tryggestad A, Bakke O, Lien E, et al. Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. EMBO J. 2006;25:3335-46 pubmed
    ..These results provide novel insight into the molecular mechanisms of TLR3-mediated signaling, which may contribute to the understanding of innate immune responses during viral infections. ..
  66. Lee J, Chang J, Yang W, Kim S, Park S, Park J, et al. Albumin-induced epithelial-mesenchymal transition and ER stress are regulated through a common ROS-c-Src kinase-mTOR pathway: effect of imatinib mesylate. Am J Physiol Renal Physiol. 2011;300:F1214-22 pubmed publisher
    ..In conclusion, the ROS-c-Src kinase-mTOR pathway played a central role in the signaling pathway that linked albumin to EMT and ER stress. Imatinib might be beneficial in attenuating the albumin-induced tubular injury. ..
  67. Samarasekera G, Auld V. C-terminal Src kinase (Csk) regulates the tricellular junction protein Gliotactin independent of Src. Mol Biol Cell. 2018;29:123-136 pubmed publisher
    ..We identified C-terminal Src kinase (Csk) as a tyrosine kinase responsible for regulating Gliotactin endocytosis...
  68. Ruzzene M, Songyang Z, Marin O, Donella Deana A, Brunati A, Guerra B, et al. Sequence specificity of C-terminal Src kinase (CSK)--a comparison with Src-related kinases c-Fgr and Lyn. Eur J Biochem. 1997;246:433-9 pubmed
    ..c-Src (Tyr527) which is conserved in most Src-related protein kinases, is phosphorylated by C-terminal Src kinase (CSK) and by the two Src-related protein kinases c-Fgr and Lyn, with similar kinetic constants...
  69. Sun G, Sharma A, Budde R. Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation. Oncogene. 1998;17:1587-95 pubmed
    b>Csk phosphorylates Src family protein tyrosine kinases on a tyrosine residue near their C-terminus and downregulates their activity...
  70. Funakoshi Tago M, Tago K, Andoh K, Sonoda Y, Tominaga S, Kasahara T. Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex. J Biochem. 2005;137:189-97 pubmed
    ..Taken together, our results suggest that c-Src plays a critical role in IL-1-induced NF-kappa B activation through the IKK complex. ..
  71. Dey N, De P, Wang M, Zhang H, Dobrota E, Robertson K, et al. CSK controls retinoic acid receptor (RAR) signaling: a RAR-c-SRC signaling axis is required for neuritogenic differentiation. Mol Cell Biol. 2007;27:4179-97 pubmed
    ..We observed that CSK negatively regulates RAR functions required for neuritogenic differentiation...
  72. Kuga T, Nakayama Y, Hoshino M, Higashiyama Y, Obata Y, Matsuda D, et al. Differential mitotic activation of endogenous c-Src, c-Yes, and Lyn in HeLa cells. Arch Biochem Biophys. 2007;466:116-24 pubmed
    ..Thus, these results suggest that endogenous c-Src, c-Yes, and Lyn are differentially activated through Cdc2 activation during M phase. ..
  73. Xu J, Weerapura M, Ali M, Jackson M, Li H, Lei G, et al. Control of excitatory synaptic transmission by C-terminal Src kinase. J Biol Chem. 2008;283:17503-14 pubmed publisher
    ..We show here that an interaction between C-terminal Src kinase (Csk) and NMDARs controls the Src-dependent regulation of NMDAR activity...
  74. Mandine E, Jean Baptiste V, Vayssière B, Gofflo D, Bénard D, Sarubbi E, et al. High-affinity Src-SH2 ligands which do not activate Tyr(527)-phosphorylated Src in an experimental in vivo system. Biochem Biophys Res Commun. 2002;298:185-92 pubmed
    ..ligands of the SH2 domain on Src kinase activation, both in vitro in an ELISA based assay and in vivo using csk and src double transformed Schizosaccharomyces pombe...
  75. Huang W, Chen J, Chen C. c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression. J Biol Chem. 2003;278:9944-52 pubmed
    ..These two pathways converge at IKKbeta and go on to activate NF-kappaB, via serine phosphorylation and degradation of IkappaB-alpha, and, finally, to initiate ICAM-1 expression. ..
  76. Lee S, Ayrapetov M, Kemble D, Parang K, Sun G. Docking-based substrate recognition by the catalytic domain of a protein tyrosine kinase, C-terminal Src kinase (Csk). J Biol Chem. 2006;281:8183-9 pubmed
    ..C-terminal Src kinase (Csk) specifically phosphorylates Src family kinases on a C-terminal Tyr residue, which down-regulates their activities...
  77. Vojtechova M, Senigl F, Sloncova E, Tuhácková Z. Regulation of c-Src activity by the expression of wild-type v-Src and its kinase-dead double Y416F-K295N mutant. Arch Biochem Biophys. 2006;455:136-43 pubmed
    ..These results suggest that dimerization of Src plays an important role in the regulation of Src tyrosine kinase activity. ..
  78. Park S, Dong B, Matsumura F. Rapid activation of c-Src kinase by dioxin is mediated by the Cdc37-HSP90 complex as part of Ah receptor signaling in MCF10A cells. Biochemistry. 2007;46:899-908 pubmed
    ..Together, these observations support the hypothesis that there is a specific coordination between the activation of the cytosolic Ah receptor and the c-Src- and cdc37-containing HSP90 complex. ..
  79. Liang F, Luo Y, Dong Y, Walls C, Liang J, Jiang H, et al. Translational control of C-terminal Src kinase (Csk) expression by PRL3 phosphatase. J Biol Chem. 2008;283:10339-46 pubmed publisher
    ..PRL3-induced Src activation is proposed to be indirect through down-regulation of Csk, a negative regulator of Src...
  80. Enomoto M, Hayakawa S, Itsukushima S, Ren D, Matsuo M, Tamada K, et al. Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling. Oncogene. 2009;28:3197-208 pubmed publisher
  81. Mikkola E, Gahmberg C. Hydrophobic interaction between the SH2 domain and the kinase domain is required for the activation of Csk. J Mol Biol. 2010;399:618-27 pubmed publisher
    The protein tyrosine kinase C-terminal Src kinase (Csk) is activated by the engagement of its Src homology (SH) 2 domain. However, the molecular mechanism required for this is not completely understood...
  82. Chung H, Park E, Pyee Y, Hua Xu G, Lee S, Kim Y, et al. 25-Methoxyhispidol A, a novel triterpenoid of Poncirus trifoliata, inhibits cell growth via the modulation of EGFR/c-Src signaling pathway in MDA-MB-231 human breast cancer cells. Food Chem Toxicol. 2011;49:2942-6 pubmed publisher
    ..These findings suggest that 25-MHA-mediated inhibitory activity of human breast cancer cell growth might be related with the cell cycle arrest and modulation of signal transduction pathways...
  83. Kim S, Yang X, Li Q, Wu M, Costyn L, Beharry Z, et al. Myristoylation of Src kinase mediates Src-induced and high-fat diet-accelerated prostate tumor progression in mice. J Biol Chem. 2017;292:18422-18433 pubmed publisher
  84. Robiou du Pont S, Anand S, Morrison K, McDonald S, Atkinson S, Teo K, et al. Parental and offspring contribution of genetic markers of adult blood pressure in early life: The FAMILY study. PLoS ONE. 2017;12:e0186218 pubmed publisher
    ..Linear mixed-effect regressions showed significant association between rs1378942 in CSK and systolic blood pressure (? = 0.98±0.46, P = 3.4×10-2)...
  85. Kunte D, Wali R, Koetsier J, Hart J, Kostjukova M, Kilimnik A, et al. Down-regulation of the tumor suppressor gene C-terminal Src kinase: an early event during premalignant colonic epithelial hyperproliferation. FEBS Lett. 2005;579:3497-502 pubmed
    ..lesions in the azoxymethane-rat model of colon carcinogenesis; the tumor suppressor gene C-terminal Src kinase (Csk) was down-regulated with a concomitant increase in Src activity...
  86. Shattil S. Integrins and Src: dynamic duo of adhesion signaling. Trends Cell Biol. 2005;15:399-403 pubmed
    ..Here, the biochemical basis for and biological significance of this integrin-SFK interaction is summarized, and I propose a general mechanism for initiation of outside-in integrin signaling. ..
  87. Takeuchi F, Isono M, Katsuya T, Yamamoto K, Yokota M, Sugiyama T, et al. Blood pressure and hypertension are associated with 7 loci in the Japanese population. Circulation. 2010;121:2302-9 pubmed publisher
    ..Significant associations were replicated for 7 loci-CASZ1, MTHFR, ITGA9, FGF5, CYP17A1-CNNM2, ATP2B1, and CSK-ULK3-with any or all of these 3 traits: systolic blood pressure (P=1.4x10(-14) to 0...
  88. Xi B, Shen Y, Zhao X, Chandak G, Cheng H, Hou D, et al. Association of common variants in/near six genes (ATP2B1, CSK, MTHFR, CYP17A1, STK39 and FGF5) with blood pressure/hypertension risk in Chinese children. J Hum Hypertens. 2014;28:32-6 pubmed publisher
    ..We genotyped six SNPs (ATP2B1 rs17249754, CSK rs1378942, MTHFR rs1801133, CYP17A1 rs1004467, STK39 rs3754777 and FGF5 rs16998073) in Chinese children (N=3077, ..
  89. Guo B, Zhang Y, Hui Q, Wang H, Tao K. Naringin suppresses the metabolism of A375 cells by inhibiting the phosphorylation of c-Src. Tumour Biol. 2016;37:3841-50 pubmed publisher
    ..More importantly, we provide the novel mechanism that, as a natural inhibitor of c-Src, naringin could be an effective candidate for the treatment of melanoma. ..
  90. Kumar R, Agrawal T, Khan N, Nakayama Y, Medigeshi G. Identification and characterization of the role of c-terminal Src kinase in dengue virus replication. Sci Rep. 2016;6:30490 pubmed publisher
    We screened a siRNA library targeting human tyrosine kinases in Huh-7 cells and identified c-terminal Src kinase (Csk) as one of the kinases involved in dengue virus replication...
  91. Davidson D, Zhong M, Pandolfi P, Bolland S, Xavier R, Seed B, et al. The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors. Cell Rep. 2016;17:2776-2788 pubmed publisher
    The transmembrane adaptor PAG (Cbp) has been proposed to mediate membrane recruitment of Csk, a cytoplasmic protein tyrosine kinase playing a critical inhibitory role during T cell activation, by inactivating membrane-associated Src ..
  92. Inderberg E, Mensali N, Oksvold M, Fallang L, Fane A, Skorstad G, et al. Human c-SRC kinase (CSK) overexpression makes T cells dummy. Cancer Immunol Immunother. 2018;67:525-536 pubmed publisher
    ..By over-expressing the c-SRC kinase (CSK), a negative regulator of LCK, in redirected T cells, we showed that peripheral blood T cells inhibited anti-CD3/..