CSF1R

Summary

Gene Symbol: CSF1R
Description: colony stimulating factor 1 receptor
Alias: C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R, macrophage colony-stimulating factor 1 receptor, CD115 antigen, CSF-1 receptor, FMS proto-oncogene, McDonough feline sarcoma viral (v-fms) oncogene homolog, macrophage colony stimulating factor I receptor, proto-oncogene c-Fms
Species: human
Products:     CSF1R

Top Publications

  1. Wilhelmsen K, Burkhalter S, van der Geer P. C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus. Oncogene. 2002;21:1079-89 pubmed
    ..Our observations are consistent with a model in which receptor autophosphorylation at Tyr 973 creates a binding site for c-Cbl. Association of c-Cbl with the receptor leads to ubiquitination, followed by receptor degradation. ..
  2. Riccioni R, Saulle E, Militi S, Sposi N, Gualtiero M, Mauro N, et al. C-fms expression correlates with monocytic differentiation in PML-RAR alpha+ acute promyelocytic leukemia. Leukemia. 2003;17:98-113 pubmed
    We have investigated the expression of the M-CSF receptor (c-fms) in 16 freshly isolated acute promyelocytic leukemias (APL) expressing the PML/RAR alpha fusion protein...
  3. Rohde C, Schrum J, Lee A. A juxtamembrane tyrosine in the colony stimulating factor-1 receptor regulates ligand-induced Src association, receptor kinase function, and down-regulation. J Biol Chem. 2004;279:43448-61 pubmed
    ..These findings may have implications for the oncogenic conversion of c-Kit and Flt3 with JMD mutations. ..
  4. Walter M, Lucet I, Patel O, Broughton S, Bamert R, Williams N, et al. The 2.7 A crystal structure of the autoinhibited human c-Fms kinase domain. J Mol Biol. 2007;367:839-47 pubmed
    c-Fms, a member of the Platelet-derived Growth Factor (PDGF) receptor family of receptor tyrosine kinases (RTKs), is the receptor for macrophage colony stimulating factor (CSF-1) that regulates proliferation, differentiation and survival ..
  5. Soares M, Pinto M, Henrique R, Vieira J, Cerveira N, Peixoto A, et al. CSF1R copy number changes, point mutations, and RNA and protein overexpression in renal cell carcinomas. Mod Pathol. 2009;22:744-52 pubmed publisher
    ..tumors and paired normal kidney samples to evaluate at the genomic and expression levels the tyrosine kinase genes CSF1R and PDGFRB as potential targets in this region...
  6. Morandi A, Barbetti V, Riverso M, Dello Sbarba P, Rovida E. The colony-stimulating factor-1 (CSF-1) receptor sustains ERK1/2 activation and proliferation in breast cancer cell lines. PLoS ONE. 2011;6:e27450 pubmed publisher
    ..The presence of a proliferative CSF-1/CSF-1R autocrine loop involving ERK1/2 was also found. The wide expression of the CSF-1/CSF-1R pair across breast cancer cell subtypes supports CSF-1/CSF-1R targeting in breast cancer therapy. ..
  7. Hume D, MacDonald K. Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling. Blood. 2012;119:1810-20 pubmed publisher
    ..As a treatment, CSF-1 has therapeutic potential in tissue repair. Conversely, inhibition of CSF-1R is unlikely to be effective in inflammatory disease but may have utility in cancer. ..
  8. Mitsui J, Matsukawa T, Ishiura H, Higasa K, Yoshimura J, Saito T, et al. CSF1R mutations identified in three families with autosomal dominantly inherited leukoencephalopathy. Am J Med Genet B Neuropsychiatr Genet. 2012;159B:951-7 pubmed publisher
    ..adult-onset sporadic leukodystrophy and one patient with pathologically proven HDLS were additionally screened for CSF1R mutations. Exome sequencing identified heterozygous CSF1R mutations (p.I794T and p.R777W) in two families...
  9. Nicholson A, Baker M, Finch N, Rutherford N, Wider C, Graff Radford N, et al. CSF1R mutations link POLD and HDLS as a single disease entity. Neurology. 2013;80:1033-40 pubmed publisher
    ..Recently, we reported that mutations in the colony-stimulating factor 1 receptor (CSF1R) gene cause HDLS. In this study, we determined whether CSF1R mutations are also a cause of POLD...

More Information

Publications103 found, 100 shown here

  1. Wrobel C, Debnath J, Lin E, Beausoleil S, Roussel M, Brugge J. Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture. J Cell Biol. 2004;165:263-73 pubmed
    ..These findings provide a mechanistic basis whereby CSF-1R could contribute to invasive progression in epithelial cancers. ..
  2. Taylor J, Brownlow N, Domin J, Dibb N. FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance. Oncogene. 2006;25:147-51 pubmed
    ..Here, we report that imatinib is also an effective inhibitor of the closely related FMS receptor for macrophage colony stimulating factor and that mutation of Asp 802 of FMS to Val confers imatinib ..
  3. Hammes L, Tekmal R, Naud P, Edelweiss M, Kirma N, Valente P, et al. Up-regulation of VEGF, c-fms and COX-2 expression correlates with severity of cervical cancer precursor (CIN) lesions and invasive disease. Gynecol Oncol. 2008;110:445-51 pubmed publisher
    ..of vascular endothelial growth factor (VEGF), proto-oncogene macrophage colony-stimulating factor receptor (c-fms) and cyclooxygenase-2 (COX-2) in cervical carcinogenesis and to analyze the correlation of VEGF with c-fms and COX-..
  4. Menke J, Kriegsmann J, Schimanski C, Schwartz M, Schwarting A, Kelley V. Autocrine CSF-1 and CSF-1 receptor coexpression promotes renal cell carcinoma growth. Cancer Res. 2012;72:187-200 pubmed publisher
    ..Furthermore, our findings imply that targeting CSF-1/CSF-1R signaling may be therapeutically effective in RCCs. ..
  5. Rademakers R, Baker M, Nicholson A, Rutherford N, Finch N, Soto Ortolaza A, et al. Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids. Nat Genet. 2011;44:200-5 pubmed publisher
    ..different mutations affecting the tyrosine kinase domain of the colony stimulating factor 1 receptor (encoded by CSF1R) in 14 families with HDLS. In one kindred, we confirmed the de novo occurrence of the mutation...
  6. van der Geer P, Hunter T. Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts. EMBO J. 1993;12:5161-72 pubmed
    ..Tyr697 was identified as a binding site for GRB2. We suggest that PI 3-kinase, GRB2 and some of the GRB2-associated proteins could play an important role in signal transduction by the CSF-1 receptor. ..
  7. Ide H, Seligson D, Memarzadeh S, Xin L, Horvath S, Dubey P, et al. Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression. Proc Natl Acad Sci U S A. 2002;99:14404-9 pubmed
    ..These observations correlate CSF-1R expression with changes in the growth and development of the normal and neoplastic prostate. ..
  8. Paniagua R, Chang A, Mariano M, Stein E, Wang Q, Lindstrom T, et al. c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis. Arthritis Res Ther. 2010;12:R32 pubmed publisher
    ..drug that potently inhibits the tyrosine kinases Abl, c-Kit, platelet-derived growth factor receptor (PDGFR), and c-Fms--ameliorates murine autoimmune arthritis...
  9. Eda H, Zhang J, Keith R, Michener M, Beidler D, Monahan J. Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood. Cytokine. 2010;52:215-20 pubmed publisher
    ..if an M-CSF- or IL-34-induced cytokine or chemokine production from HWB is inhibited by soluble M-CSF receptor or c-FMS kinase inhibitors...
  10. Zwaenepoel O, Tzenaki N, Vergetaki A, Makrigiannakis A, Vanhaesebroeck B, Papakonstanti E. Functional CSF-1 receptors are located at the nuclear envelope and activated via the p110? isoform of PI 3-kinase. FASEB J. 2012;26:691-706 pubmed publisher
    ..These findings may have important implications in cancer development. ..
  11. Kleinfeld K, Mobley B, Hedera P, Wegner A, Sriram S, Pawate S. Adult-onset leukoencephalopathy with neuroaxonal spheroids and pigmented glia: report of five cases and a new mutation. J Neurol. 2013;260:558-71 pubmed publisher
    ..by genetic analysis alone that showed a disease-causing mutation in the colony-stimulating factor 1 receptor (CSF1R) gene...
  12. Ridge S, Worwood M, Oscier D, Jacobs A, Padua R. FMS mutations in myelodysplastic, leukemic, and normal subjects. Proc Natl Acad Sci U S A. 1990;87:1377-80 pubmed
    The FMS gene encodes the functional cell surface receptor for colony-stimulating factor 1, the macrophage- and monocyte-specific growth factor...
  13. Sherr C, Rettenmier C, Sacca R, Roussel M, Look A, Stanley E. The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1. Cell. 1985;41:665-76 pubmed
    The feline c-fms proto-oncogene product is a 170 kd glycoprotein with associated tyrosine kinase activity. This glycoprotein was expressed on mature cat macrophages from peritoneal inflammatory exudates and spleen...
  14. Stanley E, Berg K, Einstein D, Lee P, Pixley F, Wang Y, et al. Biology and action of colony--stimulating factor-1. Mol Reprod Dev. 1997;46:4-10 pubmed
    ..The CSF-1R is a tyrosine kinase encoded by the c-fms proto-oncogene product...
  15. Flick M, Sapi E, Perrotta P, Maher M, Halaban R, Carter D, et al. Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibody. Oncogene. 1997;14:2553-61 pubmed
    The macrophage colony stimulating factor receptor (CSF-1R), the product of the c-fms proto-oncogene, plays an important role in regulating the normal proliferation and differentiation of macrophages and trophoblasts...
  16. Flick M, Sapi E, Kacinski B. Hormonal regulation of the c-fms proto-oncogene in breast cancer cells is mediated by a composite glucocorticoid response element. J Cell Biochem. 2002;85:10-23 pubmed
    We have previously reported that glucocorticoids markedly increase and anti-glucocorticoids (such as RU-486) block c-fms RNA and protein expression in some breast cancer cell lines, but not in others, and that this increase is the ..
  17. Yu W, Chen J, Xiong Y, Pixley F, Yeung Y, Stanley E. Macrophage proliferation is regulated through CSF-1 receptor tyrosines 544, 559, and 807. J Biol Chem. 2012;287:13694-704 pubmed publisher
    ..Tyr-559 phosphorylation releases this restraint and may also contribute to the CSF-1-regulated proliferative response by activating Src family kinase. ..
  18. Watanabe K, Hirata M, Tominari T, Matsumoto C, Fujita H, Yonekura K, et al. The MET/Vascular Endothelial Growth Factor Receptor (VEGFR)-targeted Tyrosine Kinase Inhibitor Also Attenuates FMS-dependent Osteoclast Differentiation and Bone Destruction Induced by Prostate Cancer. J Biol Chem. 2016;291:20891-20899 pubmed
    ..The phosphorylation of the macrophage colony-stimulating factor receptor FMS and osteoclast related kinases such as ERK and Akt were also suppressed by the presence of TAS-115...
  19. Garceau V, Balic A, Garcia Morales C, Sauter K, McGrew M, Smith J, et al. The development and maintenance of the mononuclear phagocyte system of the chick is controlled by signals from the macrophage colony-stimulating factor receptor. BMC Biol. 2015;13:12 pubmed publisher
    ..by macrophage colony-stimulating factor (CSF1) and interleukin 34 (IL34), both agonists of the CSF1 receptor (CSF1R)...
  20. di Spigna G, Iannone M, Ladogana P, Salzano S, Ventre M, Covelli B, et al. Human cardiac multipotent adult stem cells in 3D matrix: new approach of tissue engineering in cardiac regeneration post-infarction. J Biol Regul Homeost Agents. 2017;31:911-921 pubmed
    ..We also evaluated the expression levels of the Granulocyte Macrophage-Colony Stimulating Factor Receptor (GM-CSFR) and endoglin, a component of the Transforming Growth Factor beta (TGF-ß) receptor complex...
  21. Mooney C, Cunningham A, Tsapogas P, Toellner K, Brown G. Selective Expression of Flt3 within the Mouse Hematopoietic Stem Cell Compartment. Int J Mol Sci. 2017;18: pubmed publisher
    ..The erythropoietin receptor (EpoR) and macrophage colony-stimulating factor receptor (M-CSFR) were also found to be heterogeneously expressed within the multipotent cell compartments...
  22. Cook A, Louis C, Robinson M, Saleh R, Sleeman M, Hamilton J. Granulocyte macrophage colony-stimulating factor receptor ? expression and its targeting in antigen-induced arthritis and inflammation. Arthritis Res Ther. 2016;18:287 pubmed
    Blockade of granulocyte macrophage colony-stimulating factor (GM-CSF) and its receptor (GM-CSFR?) is being successfully tested in trials in rheumatoid arthritis (RA) with clinical results equivalent to those found with neutralization of ..
  23. Ramaglia L, di Spigna G, Capece G, Sbordone C, Salzano S, Postiglione L. Differentiation, apoptosis, and GM-CSF receptor expression of human gingival fibroblasts on a titanium surface treated by a dual acid-etched procedure. Clin Oral Investig. 2015;19:2245-53 pubmed publisher
    ..matrix (ECM) proteins, and expression of granulocyte macrophage-colony stimulating factor receptor (GM-CSFR) were investigated using in each experiment a total of 18 samples for each titanium surface...
  24. Matsumoto Y, Taki T, Fujimoto Y, Taniguchi K, Shimizu D, Shimura K, et al. Monosomies 7p and 12p and FLT3 internal tandem duplication: possible markers for diagnosis of T/myeloid biphenotypic acute leukemia and its clonal evolution. Int J Hematol. 2009;89:352-358 pubmed publisher
    ..biphenotypic acute leukemia showing clonal chromosomal and genetic abnormalities including dic(7;12)(p11;p11) and Fms-like tyrosine kinase 3 (FLT3)-internal tandem duplication...
  25. Capio C, Mak T, Tse M, Masters R. Fundamental movement skills and balance of children with Down syndrome. J Intellect Disabil Res. 2017;: pubmed publisher
    Conclusive evidence supports the importance of fundamental movement skills (FMS) proficiency in promoting physical activity and countering obesity...
  26. Sun W, Feng W, Lu H, Gong S. Synaptic plasticity in the facial nucleus in rats following infraorbital nerve manipulation after facial nerve injury. Eur Arch Otorhinolaryngol. 2016;273:3135-42 pubmed publisher
    ..groups: (1) sham control; (2) facial nerve crush (FNC); (3) nerve crush plus daily manual vibrissal stimulation (FMS); and (4) nerve crush with infraorbital nerve transection plus daily manual stimulation (FIMS)...
  27. Mishra V, Sinha S, Rajavashisth T. Role of macrophage colony-stimulating factor in the development of neointimal thickening following arterial injury. Cardiovasc Pathol. 2016;25:284-292 pubmed publisher
    ..We examined the expression of M-CSF and its receptor, c-fms, in rodent and rabbit models of arterial injury...
  28. Triunfo S, Crovetto F, Rodríguez Sureda V, Scazzocchio E, Crispi F, Dominguez C, et al. Changes in uterine artery Doppler velocimetry and circulating angiogenic factors in the first half of pregnancies delivering a small-for-gestational-age neonate. Ultrasound Obstet Gynecol. 2017;49:357-363 pubmed publisher
    ..uterine artery (UtA) Doppler indices and maternal circulating levels of placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) were analyzed...
  29. Jinjun W, Zhaowei W, Qiang L, Zhijun X, Juanzi Z, Lin L, et al. sFLT-1 inhibits proliferation, migration, and invasion of colorectal cancer SW480 cells through vascular mimicry formation suppression. Tumour Biol. 2017;39:1010428317698339 pubmed publisher
    To investigate the effects of soluble fms-like tyrosine kinase-1 on the vascular mimicry formation, proliferation, migration, and invasion of colorectal cancer SW480 cells...
  30. Lotinun S, Suwanwela J, Poolthong S, Baron R. Kit W-sh Mutation Prevents Cancellous Bone Loss during Calcium Deprivation. Calcif Tissue Int. 2018;102:93-104 pubmed publisher
    ..Gene expression profiling showed that calcium deficiency increased Osx, Ocn, Alp, type I collagen, c-Fms, M-CSF, and RANKL/OPG mRNA expression in controls; however, the W sh mutation suppressed these effects...
  31. Wang Y, Miyazaki R, Saitou S, Hirasaka K, Takeshita S, Tachibana K, et al. The Effect of Ice Crystals Formations on the Flesh Quality of Frozen Horse Mackerel (Trachurus japonicus). J Texture Stud. 2017;: pubmed publisher
    ..histological structure (light microscope: LM, scanning electron microscope: SEM) of UMS, frozen muscle specimens (FMS) and F-TMS were investigated...
  32. Zhao X, Wang Z, Ruan G, Liu Y, Wang Y, Zhang X, et al. Impact of pre-transplantation minimal residual disease determined by multiparameter flow cytometry on the outcome of AML patients with FLT3-ITD after allogeneic stem cell transplantation. Ann Hematol. 2018;97:967-975 pubmed publisher
    ..of minimal residual disease prior to transplantation (pre-MRD) on the transplant outcomes of AML patients with fms-related tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) mutation...
  33. Chase A, Schultheis B, Kreil S, Baxter J, Hidalgo Curtis C, Jones A, et al. Imatinib sensitivity as a consequence of a CSF1R-Y571D mutation and CSF1/CSF1R signaling abnormalities in the cell line GDM1. Leukemia. 2009;23:358-64 pubmed publisher
    ..of genes encoding known imatinib targets revealed an exon 12 mutation in the colony-stimulating factor 1 receptor (CSF1R; c-FMS) with a predicted Y571D amino-acid substitution...
  34. Khalil A, Maiz N, Garcia Mandujano R, Penco J, Nicolaides K. Longitudinal changes in maternal serum placental growth factor and soluble fms-like tyrosine kinase-1 in women at increased risk of pre-eclampsia. Ultrasound Obstet Gynecol. 2016;47:324-31 pubmed publisher
    To investigate longitudinal changes in maternal serum levels of placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in pregnant women who develop pre-eclampsia (PE) or gestational hypertension (GH)...
  35. Van Overmeire E, Stijlemans B, Heymann F, Keirsse J, Morias Y, Elkrim Y, et al. M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment. Cancer Res. 2016;76:35-42 pubmed publisher
    ..We demonstrate that treatment of tumor-bearing mice with a blocking anti-M-CSFR monoclonal antibody resulted in a reduction of mature TAMs due to impaired recruitment, extravasation, ..
  36. Auray G, Keller I, Python S, Gerber M, Bruggmann R, Ruggli N, et al. Characterization and Transcriptomic Analysis of Porcine Blood Conventional and Plasmacytoid Dendritic Cells Reveals Striking Species-Specific Differences. J Immunol. 2016;197:4791-4806 pubmed
    ..cells, cDC2 are CD135+CD14-CD172a+CADM1+CD115+wCD11R1+CD1+ cells and pDCs are CD4+CD135+CD172a+..
  37. Ryu S, Na H, Sohn M, Choi W, In H, Shin H, et al. Competent antigen-presenting cells are generated from the long-term culture of splenocytes with granulocyte-macrophage colony-stimulating factor. Immunol Lett. 2017;188:96-107 pubmed publisher
    ..In parallel experiments, FMS-like tyrosine kinase 3 (FLT3) and its ligand, FLT3L, were not found to influence the culture of splenocytes...
  38. McGrane B, Belton S, Fairclough S, Powell D, Issartel J. Outcomes of the Y-PATH Randomized Controlled Trial: Can a School-Based Intervention Improve Fundamental Movement Skill Proficiency in Adolescent Youth?. J Phys Act Health. 2017;:1-10 pubmed publisher
    ..school-based interventions are considered to be an effective method for improving fundamental movement skill (FMS) proficiency levels and physical activity (PA) among youth...
  39. Patsialou A, Wang Y, Pignatelli J, Chen X, Entenberg D, Oktay M, et al. Autocrine CSF1R signaling mediates switching between invasion and proliferation downstream of TGF? in claudin-low breast tumor cells. Oncogene. 2015;34:2721-31 pubmed publisher
    Patient data suggest that colony-stimulating factor-1 (CSF1) and its receptor (CSF1R) have critical roles during breast cancer progression...
  40. Kang H, Lee S, Jeon H, Choi Y, Kim S, Lee W, et al. A functional polymorphism in CSF1R gene is a novel susceptibility marker for lung cancer among never-smoking females. J Thorac Oncol. 2014;9:1647-55 pubmed publisher
    ..Among 16 SNPs, three SNPs (colony-stimulating factor 1 receptor [CSF1R] rs10079250A>G, tumor protein p63 [TP63] rs7631358G>A, and corepressor interacting with RBPJ 1 [CIR1] ..
  41. Kaitu u Lino T, Tong S, Beard S, Hastie R, Tuohey L, Brownfoot F, et al. Characterization of protocols for primary trophoblast purification, optimized for functional investigation of sFlt-1 and soluble endoglin. Pregnancy Hypertens. 2014;4:287-95 pubmed publisher
    Soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng) are the most studied molecules in preeclampsia. However, most trophoblast cell lines do not secrete both these factors...
  42. Choudhary S, Goetjen A, Estus T, Jacome Galarza C, Aguila H, Lorenzo J, et al. Serum Amyloid A3 Secreted by Preosteoclasts Inhibits Parathyroid Hormone-stimulated cAMP Signaling in Murine Osteoblasts. J Biol Chem. 2016;291:3882-94 pubmed publisher
    ..sorting of WT marrow revealed that Saa3 was secreted only from the RANKL-stimulated B220(-) CD3(-)CD11b(-/low) CD115(+) preosteoclast population...
  43. Qiu Y, Zhang Y, Hu N, Dong F. A Truncated Granulocyte Colony-stimulating Factor Receptor (G-CSFR) Inhibits Apoptosis Induced by Neutrophil Elastase G185R Mutant: IMPLICATION FOR UNDERSTANDING CSF3R GENE MUTATIONS IN SEVERE CONGENITAL NEUTROPENIA. J Biol Chem. 2017;292:3496-3505 pubmed publisher
    ..to AML is accompanied by mutations in CSF3R encoding the granulocyte colony-stimulating factor receptor (G-CSFR) in ∼80% of patients...
  44. Tamai M, Furuichi Y, Kasai S, Ando N, Harama D, Goi K, et al. TGFβ1 synergizes with FLT3 ligand to induce chemoresistant quiescence in acute lymphoblastic leukemia with MLL gene rearrangements. Leuk Res. 2017;61:68-76 pubmed publisher
    b>Fms-like tyrosine kinase 3 (FLT3) is highly expressed in mixed-lineage leukemia (MLL) gene-rearranged acute lymphoblastic leukemia (MLL+ALL) with a dismal prognosis...
  45. Altan S, Sagsoz H, Ogurtan Z. Topical dimethyl sulfoxide inhibits corneal neovascularization and stimulates corneal repair in rabbits following acid burn. Biotech Histochem. 2017;92:619-636 pubmed publisher
    ..Each cornea was fixed with 10% neutral formalin. On days 2, 7 and 14, VEGF, flk1/KDR and flt1/fms were strongly expressed in the epithelial, stromal and inflammatory cells, but not in the corneal endothelial cells...
  46. Claßen Bockhoff R, Arndt M. Flower-like heads from flower-like meristems: pseudanthium development in Davidia involucrata (Nyssaceae). J Plant Res. 2018;131:443-458 pubmed publisher
    ..The similarity among FUMs and FMs raises the question how far flower-like heads originate from flower-like meristems...
  47. Lamprecht B, Walter K, Kreher S, Kumar R, Hummel M, Lenze D, et al. Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma. Nat Med. 2010;16:571-9, 1p following 579 pubmed publisher
    ..cells depend on the activity of the non-B, myeloid-specific proto-oncogene colony-stimulating factor 1 receptor (CSF1R)...
  48. Sun G, Wang L, Bao C, Li T, Ma L, Chen L. Complete Genome Sequence of Elizabethkingia meningoseptica, Isolated from a T-Cell Non-Hodgkin's Lymphoma Patient. Genome Announc. 2015;3: pubmed publisher
    ..The complete genome of this isolated strain, FMS-007, was generated in one contig with a total size of 3,938,967 bp...
  49. Yu G, Aye C, Lewandowski A, Davis E, Khoo C, Newton L, et al. Association of Maternal Antiangiogenic Profile at Birth With Early Postnatal Loss of Microvascular Density in Offspring of Hypertensive Pregnancies. Hypertension. 2016;68:749-59 pubmed publisher
    ..Maternal angiogenic profile (soluble fms-like tyrosine kinase-1, soluble endoglin, vascular endothelial growth factor, and placental growth factor) was ..
  50. Grand Maison S, Pilote L, Okano M, Landry T, Dayan N. Markers of Vascular Dysfunction After Hypertensive Disorders of Pregnancy: A Systematic Review and Meta-Analysis. Hypertension. 2016;68:1447-1458 pubmed
    ..025 mm [0.004-0.045]), and augmentation index (5.48% [1.58-9.37]), as well as mean levels of soluble fms-like tyrosine kinase (6.12 pg/mL [1.91-10.33])...
  51. Elsegood C, Zhuo Y, Wesolowski G, Hamilton J, Rodan G, Duong L. M-CSF induces the stable interaction of cFms with alphaVbeta3 integrin in osteoclasts. Int J Biochem Cell Biol. 2006;38:1518-29 pubmed
  52. Liu G, Abraham S, Liu X, Xu S, Rooks A, Nepomuceno R, et al. Discovery and optimization of a highly efficacious class of 5-aryl-2-aminopyridines as FMS-like tyrosine kinase 3 (FLT3) inhibitors. Bioorg Med Chem Lett. 2015;25:3436-41 pubmed publisher
    Based on a putative binding mode of quizartinib (AC220, 1), a potent FMS-like tyrosine kinase 3 (FLT3) inhibitor in Phase III clinical development, we have designed de novo a simpler aminopyridine-based hinge binding motif...
  53. Häuser W, Bernardy K. [Psychotherapeutic procedures for fibromyalgia syndrome]. Z Rheumatol. 2015;74:584-90 pubmed publisher
    Psychosocial factors play an important role in the predisposition, triggering and course of fibromyalgia syndrome (FMS)...
  54. Arslan E, Yildiz S, Albayrak Y, Koklukaya E. Rule based fuzzy logic approach for classification of fibromyalgia syndrome. Australas Phys Eng Sci Med. 2016;39:501-15 pubmed publisher
    Fibromyalgia syndrome (FMS) is a chronic muscle and skeletal system disease observed generally in women, manifesting itself with a widespread pain and impairing the individual's quality of life...
  55. Taylor S, Langdon W. Hitting the snooze button: Inducing quiescence with the FLT3 inhibitor quizartinib protects hematopoietic progenitors from chemotherapy. Mol Cell Oncol. 2017;4:e1378156 pubmed publisher
    ..work outlines a strategy to prevent chemotherapy-induced myelosuppression by administering a priming dose of the FMS-Like Tyrosine kinase 3 (FLT3) inhibitor quizartinib...
  56. Saleh L, Samantar R, Garrelds I, van den Meiracker A, Visser W, Danser A. Low Soluble Fms-Like Tyrosine Kinase-1, Endoglin, and Endothelin-1 Levels in Women With Confirmed or Suspected Preeclampsia Using Proton Pump Inhibitors. Hypertension. 2017;70:594-600 pubmed publisher
    Patients with preeclampsia display elevated placenta-derived sFlt-1 (soluble Fms-like tyrosine kinase-1) and endoglin levels and decreased placental growth factor levels...
  57. Lachkar S, Guisier F, Roger M, Obstoy B, Bota S, Lerouge D, et al. Assessment of Per-Endoscopic Placement of Fiducial Gold Markers for Small Peripheral Lung Nodules < 20 mm Before Stereotactic Radiation Therapy. Chest. 2017;: pubmed publisher
    ..Placement of fiducial gold markers (FMs) is crucial for tracking small lesions that are not visible on chest radiographs...
  58. Zhou S, Schmidt H. Mn-doped Ge and Si: A Review of the Experimental Status. Materials (Basel). 2010;3:5054-5082 pubmed publisher
    Diluted ferromagnetic semiconductors (FMS) are in the focus of intense research due to their potential applications in spintronics and their striking new physical properties...
  59. Tanaka S, Neff L, Baron R, Levy J. Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways. J Biol Chem. 1995;270:14347-51 pubmed
    ..These results suggest that c-Cbl is involved in the signaling pathways utilized by different types of tyrosine kinases. ..
  60. Gastier J, Brody T, Pulido J, Businga T, Sunden S, Hu X, et al. Development of a screening set for new (CAG/CTG)n dynamic mutations. Genomics. 1996;32:75-85 pubmed
    ..The 141 STSs that were developed based on (CAG/CTG)n repeats of at least seven units were genotyped on four reference CEPH individuals to estimate their polymorphic quality. ..
  61. Mathas S, Kreher S, Meaburn K, Johrens K, Lamprecht B, Assaf C, et al. Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma. Proc Natl Acad Sci U S A. 2009;106:5831-6 pubmed publisher
    ..Also, our data demonstrate that deregulation of breakpoint-proximal genes has a key role in ALCL. ..
  62. Santiago Font J, Amaral L, Faulkner J, Ibrahim T, Vaka V, Cunningham M, et al. Serelaxin improves the pathophysiology of placental ischemia in the reduced uterine perfusion pressure rat model of preeclampsia. Am J Physiol Regul Integr Comp Physiol. 2016;311:R1158-R1163 pubmed publisher
    ..resistance index (UARI) and nitric oxide bioavailability, and/or decrease prepro-endothelin-1 (PPET-1), soluble fms-like tyrosine kinase-1 (sFlt-1), and TNF-α) in the reduced uterine perfusion pressure (RUPP) model of ..
  63. Rezaei N, Arandi N, Valibeigi B, Haghpanah S, Khansalar M, Ramzi M. FMS-Like Tyrosine Kinase 3 (FLT3) and Nucleophosmin 1 (NPM1) in Iranian Adult Acute Myeloid Leukemia Patients with Normal Karyotypes: Mutation Status and Clinical and Laboratory Characteristics. Turk J Haematol. 2017;34:300-306 pubmed publisher
    In this study, we evaluated the frequency of FMS-like tyrosine kinase 3 (FLT3-ITD and FLT3-TKD) and nucleophosmin (NPM1) mutations in Iranian patients with cytogenetically normal acute myeloid leukemia (CN-AML)...
  64. Lowenstein P, Castro M. Evolutionary basis of a new gene- and immune-therapeutic approach for the treatment of malignant brain tumors: from mice to clinical trials for glioma patients. Clin Immunol. 2018;189:43-51 pubmed publisher
    ..The second adenovirus expresses the cytokine fms-like tyrosine kinase 3 ligand (Flt3L)...
  65. Smith L, Creps J, Bean R, Rodda B, Alsalaheen B. Performance of high school male athletes on the Functional Movement Screenâ„¢. Phys Ther Sport. 2017;27:17-23 pubmed publisher
    1) Describe the performance of the Functional Movement Screen™ (FMS™) by reporting the proportion of adolescents with a score of ≤14 and the frequency of asymmetries in a cross-sectional sample; (2) explore ..
  66. Padmanabhan S, Lee V, McLean M, Athayde N, Lanzarone V, Khoshnow Q, et al. The Association of Falling Insulin Requirements With Maternal Biomarkers and Placental Dysfunction: A Prospective Study of Women With Preexisting Diabetes in Pregnancy. Diabetes Care. 2017;40:1323-1330 pubmed publisher
    ..Maternal circulating angiogenic markers (placental growth factor [PlGF] and soluble fms-like tyrosine kinase 1 [sFlt-1]), placental hormones (human placental lactogen, progesterone, and tumor necrosis ..
  67. Stansfield L, Pollyea D. Midostaurin: A New Oral Agent Targeting FMS-Like Tyrosine Kinase 3-Mutant Acute Myeloid Leukemia. Pharmacotherapy. 2017;: pubmed publisher
    ..Midostaurin is a first-generation FMS-like tyrosine kinase 3 (FLT3) inhibitor (TKI) that was approved by the U.S...
  68. Busch A, Clifton D, Onate J, Ramsey V, Cromartie F. RELATIONSHIP OF PRESEASON MOVEMENT SCREENS WITH OVERUSE SYMPTOMS IN COLLEGIATE BASEBALL PLAYERS. Int J Sports Phys Ther. 2017;12:960-966 pubmed
    The shoulder mobility screen of the Functional Movement Screen™ (FMS™) and the upper extremity patterns of the Selective Functional Movement Assessment (SFMA) assess global, multi-joint movement capabilities in the upper-extremities...
  69. Roussel M, Cleveland J, Shurtleff S, Sherr C. Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling. Nature. 1991;353:361-3 pubmed
    ..These studies demonstrate a receptor-mediated bifurcation of intracellular signal transduction pathways during the immediate early response and assign a central role for c-myc in CSF-1-induced mitogenesis. ..
  70. Fuhrman B, Partoush A, Volkova N, Aviram M. Ox-LDL induces monocyte-to-macrophage differentiation in vivo: Possible role for the macrophage colony stimulating factor receptor (M-CSF-R). Atherosclerosis. 2008;196:598-607 pubmed
    ..We thus conclude that Ox-LDL induces monocyte differentiation to macrophages in vivo and this phenomenon involves activation of the M-CSF-receptor. ..
  71. Zhenilo S, Khrameeva E, Tsygankova S, Zhigalova N, Mazur A, Prokhortchouk E. Individual genome sequencing identified a novel enhancer element in exon 7 of the CSFR1 gene by shift of expressed allele ratios. Gene. 2015;566:223-8 pubmed publisher
    ..5-fold from equal biallelic transcription. Of these genes, the CSF1R gene had variations in genic regions that affected the association of RORalpha with its target binding site in ..
  72. Brownfoot F, Tong S, Hannan N, Hastie R, Cannon P, Kaitu u Lino T. Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta. BMC Pregnancy Childbirth. 2016;16:117 pubmed publisher
    Preeclampsia is associated with the placental release of soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG). These anti-angiogenic factors cause hypertension and multi-organ injury...
  73. Lega R, Megson D, Hartley C, Crozier P, MacPherson K, Kolic T, et al. Congener specific determination of polychlorinated naphthalenes in sediment and biota by gas chromatography high resolution mass spectrometry. J Chromatogr A. 2017;1479:169-176 pubmed publisher
    ..Sample extracts were cleaned up using either a manual two-stage open column procedure or an automated FMS Power Prep System with multi-analyte and multi-sample capability using a three-column cleanup procedure...
  74. Sha Z, Wang L, Sun L, Chen Y, Zheng Y, Xin M, et al. Isolation and characterization of monocyte/macrophage from peripheral blood of half smooth tongue sole (Cynoglossus semilaevis). Fish Shellfish Immunol. 2017;65:256-266 pubmed publisher
    ..macrophage features such as phagocytic capability, positive esterase activity, and the considerable expression of M-CSFR, MHC-II, IL-6, IL-10, TNF and arginase genes...
  75. Iturri L, Saenz Coronilla J, Lallemand Y, Gomez Perdiguero E. Identification Of Erythromyeloid Progenitors And Their Progeny In The Mouse Embryo By Flow Cytometry. J Vis Exp. 2017;: pubmed publisher
    ..We have established a tamoxifen-inducible fate mapping protocol based on expression of the macrophage cytokine receptor Csf1r promoter to characterize EMP and EMP-derived cells in vivo by flow cytometry.
  76. Gray K, Saxena R, Karumanchi S. Genetic predisposition to preeclampsia is conferred by fetal DNA variants near FLT1, a gene involved in the regulation of angiogenesis. Am J Obstet Gynecol. 2018;218:211-218 pubmed publisher
    ..from preeclamptic women and 308,292 population controls identified a single association signal close to the Fms-like tyrosine kinase 1 gene, on chromosome 13...
  77. Chalmers S, Debenedictis T, Zacharia A, Townsley S, Gleeson C, Lynagh M, et al. Asymmetry during Functional Movement Screening and injury risk in junior football players: A replication study. Scand J Med Sci Sports. 2017;: pubmed publisher
    An indicator of movement quality and potential injury risk during Functional Movement Screen (FMS) testing is the presence of asymmetry when comparing the left and right sides of the body...
  78. Boultwood J, Rack K, Kelly S, Madden J, Sakaguchi A, Wang L, et al. Loss of both CSF1R (FMS) alleles in patients with myelodysplasia and a chromosome 5 deletion. Proc Natl Acad Sci U S A. 1991;88:6176-80 pubmed
    ..granulocyte/macrophage-colony-stimulating factor, and the receptor for macrophage-colony-stimulating factor [the CSF1R (formerly FMS) gene product], have been localized to the long arm of chromosome 5, and there has been much ..
  79. Rettenmier C, Roussel M, Sherr C. The colony-stimulating factor 1 (CSF-1) receptor (c-fms proto-oncogene product) and its ligand. J Cell Sci Suppl. 1988;9:27-44 pubmed
    ..The c-fms proto-oncogene encodes the CSF-1 receptor, which is composed of an extracellular ligand-binding domain linked by a ..
  80. Lioubin M, Myles G, Carlberg K, Bowtell D, Rohrschneider L. Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells. Mol Cell Biol. 1994;14:5682-91 pubmed
    b>Fms, the macrophage colony-stimulating factor (M-CSF) receptor, is normally expressed in myeloid cells and initiates signals for both growth and development along the monocyte/macrophage lineage...
  81. Auffray C, Sieweke M, Geissmann F. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol. 2009;27:669-92 pubmed publisher
    ..In adult mice, monocytes originate in the bone marrow in a Csf-1R (MCSF-R, CD115)-dependent manner from a hematopoietic precursor common for monocytes and several subsets of macrophages and ..
  82. Gubina M, Babenko V, Ivanoshchuk D, Shuryaeva A, Latieva O, Solov eva I, et al. [Gene Polymorphism of the c-fms, ITGB3,CCR2, and DBH genes in the populations of old believers of the Tyumen oblast and Russian residents of Novosibirsk]. Mol Biol (Mosk). 2016;50:246-54 pubmed publisher
    ..genes for glycoprotein ITGB3, dopamine-?-hydroxylase (DBH), and chemokine receptor CCR2 and two mutations in the c-fms gene have been analyzed. The populations are only similar in the c-fms indel...
  83. Bus P, Scharpfenecker M, Van Der Wilk P, Wolterbeek R, Bruijn J, Baelde H. The VEGF-A inhibitor sFLT-1 improves renal function by reducing endothelial activation and inflammation in a mouse model of type 1 diabetes. Diabetologia. 2017;60:1813-1821 pubmed publisher
    ..aim of this study was to investigate whether transfecting mice with the VEGF-A inhibitor sFlt-1 (encoding soluble fms-related tyrosine kinase 1) can reverse pre-existing kidney damage in a mouse model of type 1 diabetes...
  84. Himuro N, Nishibu H, Abe H, Mori M. The criterion validity and intra-rater reliability of the Japanese version of the Functional Mobility Scale in children with cerebral palsy. Res Dev Disabil. 2017;68:20-26 pubmed publisher
    The purpose of this study was to develop a Japanese version of the Functional Mobility Scale (FMS), and examine the criterion validity and intra-rater reliability of the FMS in Japan...
  85. Tamura A, Hirai H, Yokota A, Kamio N, Sato A, Shoji T, et al. C/EBPβ is required for survival of Ly6C- monocytes. Blood. 2017;130:1809-1818 pubmed publisher
    ..Expression of Csf1r, which encodes a receptor for macrophage colony-stimulating factor, was significantly reduced in Ly6C-
  86. Gregory M, Nemkov T, Reisz J, Zaberezhnyy V, Hansen K, D Alessandro A, et al. Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia. Exp Hematol. 2018;58:52-58 pubmed publisher
    ..More effective and better-tolerated therapies for AML are desperately needed. Activating mutations in FMS-like tyrosine kinase 3 (FLT3) are one of the most frequently observed genetic defects in AML...
  87. Wasenius N, Grattan K, Harvey A, Naylor P, Goldfield G, Adamo K. The effect of a physical activity intervention on preschoolers' fundamental motor skills - A cluster RCT. J Sci Med Sport. 2018;21:714-719 pubmed publisher
    ..CC), with or without a parent-driven home physical activity component, on children's fundamental motor skills (FMS). Six-month 3-arm cluster randomized controlled trial. Preschoolers were recruited from 18 licensed CC...
  88. Hampe A, Shamoon B, Gobet M, Sherr C, Galibert F. Nucleotide sequence and structural organization of the human FMS proto-oncogene. Oncogene Res. 1989;4:9-17 pubmed
    The human proto-oncogene c-fms [FMS] on chromosome 5q33.3 encodes a transmembrane glycoprotein with tyrosine kinase activity that functions as the cell surface receptor for the macrophage colony stimulating factor (CSF-1 or M-CSF)...
  89. Hiasa M, Abe M, Nakano A, Oda A, Amou H, Kido S, et al. GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-alpha converting enzyme (TACE). Blood. 2009;114:4517-26 pubmed publisher
    ..These results reveal a novel proteolytic regulation of M-CSF receptor expression in monocytes to control M-CSF signaling and monocytic differentiation into macrophage/OC-lineage cells or DCs. ..
  90. Woo H, Yi X, Lamb T, Menzl I, Baker T, Shapiro D, et al. Posttranscriptional suppression of proto-oncogene c-fms expression by vigilin in breast cancer. Mol Cell Biol. 2011;31:215-25 pubmed publisher
    ..By binding a novel non-AU-rich 69-nucleotide (nt) c-fms 3' UTR sequence, we previously identified HuR as a promoter of c-fms proto-oncogene mRNA...
  91. Haegel H, Thioudellet C, Hallet R, Geist M, Menguy T, Le Pogam F, et al. A unique anti-CD115 monoclonal antibody which inhibits osteolysis and skews human monocyte differentiation from M2-polarized macrophages toward dendritic cells. MAbs. 2013;5:736-47 pubmed publisher
    ..Both cell types are controlled by the CD115 (CSF-1R)/colony-stimulating factor-1 (CSF-1, M-CSF) pathway, making CD115 a promising target for cancer therapy...
  92. Konno T, Yoshida K, Mizuno T, Kawarai T, Tada M, Nozaki H, et al. Clinical and genetic characterization of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia associated with CSF1R mutation. Eur J Neurol. 2017;24:37-45 pubmed publisher
    The clinical characteristics of colony stimulating factor 1 receptor (CSF1R) related adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) have been only partially elucidated...