CRYGC

Summary

Gene Symbol: CRYGC
Description: crystallin gamma C
Alias: CCL, CRYG3, CTRCT2, gamma-crystallin C, gamma-crystallin 2-1, gamma-crystallin 3
Species: human
Products:     CRYGC

Top Publications

  1. Zhang L, Fu S, Ou Y, Zhao T, Su Y, Liu P. A novel nonsense mutation in CRYGC is associated with autosomal dominant congenital nuclear cataracts and microcornea. Mol Vis. 2009;15:276-82 pubmed
    To report the identification of a novel nonsense mutation in CRYGC in a Chinese family with autosomal dominant congenital nuclear cataracts and microcornea...
  2. Santana A, Waiswol M, Arcieri E, Cabral de Vasconcellos J, Barbosa de Melo M. Mutation analysis of CRYAA, CRYGC, and CRYGD associated with autosomal dominant congenital cataract in Brazilian families. Mol Vis. 2009;15:793-800 pubmed
    ..The purpose of this study was to investigate mutations in alphaA-crystallin (CRYAA), gammaC-crystallin (CRYGC), and gammaD-crystallin (CRYGD) in Brazilian families with nuclear and lamellar autosomal dominant congenital ..
  3. Li X, Cai H, Zhou S, Yang J, Xi Y, Gao X, et al. A novel mutation impairing the tertiary structure and stability of ?C-crystallin (CRYGC) leads to cataract formation in humans and zebrafish lens. Hum Mutat. 2012;33:391-401 pubmed publisher
    ..In this study, we identified a novel, heterozygous c.385G<T mutation in CRYGC that resulted in the substitution of a highly conserved glycine by cysteine at codon 129 (p...
  4. Lampi K, Ma Z, Shih M, Shearer T, Smith J, Smith D, et al. Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens. J Biol Chem. 1997;272:2268-75 pubmed
    ..These studies were a prerequisite for future studies to determine how human lens proteins are altered during aging and cataract formation. ..
  5. Fu L, Liang J. Alteration of protein-protein interactions of congenital cataract crystallin mutants. Invest Ophthalmol Vis Sci. 2003;44:1155-9 pubmed
    ..to the following crystallin genes involved in some congenital cataracts: CRYAA (R116C), CRYAB (R120G), and CRYGC (T5P). A mammalian two-hybrid system was used to assay the protein-protein interactions...
  6. Liang J. Interactions and chaperone function of alphaA-crystallin with T5P gammaC-crystallin mutant. Protein Sci. 2004;13:2476-82 pubmed
  7. Brakenhoff R, Aarts H, Reek F, Lubsen N, Schoenmakers J. Human gamma-crystallin genes. A gene family on its way to extinction. J Mol Biol. 1990;216:519-32 pubmed
  8. Graw J. The crystallins: genes, proteins and diseases. Biol Chem. 1997;378:1331-48 pubmed
    ..It has evolved from a quinone oxidoreductase using a lens-specific promoter, and a mutation in xi-crystallin is involved in cataract formation. ..
  9. Heon E, Priston M, Schorderet D, Billingsley G, Girard P, Lubsen N, et al. The gamma-crystallins and human cataracts: a puzzle made clearer. Am J Hum Genet. 1999;65:1261-7 pubmed
    ..original Coppock-like-cataract family identified a missense mutation in a highly conserved segment of exon 2 of CRYGC. These mutations were not seen in a large control population...

More Information

Publications124 found, 100 shown here

  1. Ren Z, Li A, Shastry B, Padma T, Ayyagari R, Scott M, et al. A 5-base insertion in the gammaC-crystallin gene is associated with autosomal dominant variable zonular pulverulent cataract. Hum Genet. 2000;106:531-7 pubmed
    ..This finding suggests that the appropriate association of mutant betagamma-crystallins into oligomers is not necessary to cause cataracts and may give us new insights into the genetic mechanism of cataract formation. ..
  2. Fu L, Liang J. Detection of protein-protein interactions among lens crystallins in a mammalian two-hybrid system assay. J Biol Chem. 2002;277:4255-60 pubmed
    ..These results show that the two-hybrid system can detect interactions among various crystallins and may be used in mapping interaction domains. ..
  3. Santhiya S, Shyam Manohar M, Rawlley D, Vijayalakshmi P, Namperumalsamy P, Gopinath P, et al. Novel mutations in the gamma-crystallin genes cause autosomal dominant congenital cataracts. J Med Genet. 2002;39:352-8 pubmed
  4. Shiloh Y, Donlon T, Bruns G, Breitman M, Tsui L. Assignment of the human gamma-crystallin gene cluster (CRYG) to the long arm of chromosome 2, region q33-36. Hum Genet. 1986;73:17-9 pubmed
    ..The gamma-crystallin genes map to the same chromosomal region as IDH-1. Similar linkage exists between the loci Len-1 and Idh-1 on mouse chromosome 1. ..
  5. Slingsby C, Clout N. Structure of the crystallins. Eye (Lond). 1999;13 ( Pt 3b):395-402 pubmed
    ..The precise sites of post-translational modifications are now being mapped to the various crystallins. ..
  6. Fu L, Liang J. Conformational change and destabilization of cataract gammaC-crystallin T5P mutant. FEBS Lett. 2002;513:213-6 pubmed
    ..b>CRYGC (T5P) is one of the many gamma-crystallin mutant genes for autosomal dominant congenital cataracts...
  7. Gonzalez Huerta L, Messina Baas O, Cuevas Covarrubias S. A family with autosomal dominant primary congenital cataract associated with a CRYGC mutation: evidence of clinical heterogeneity. Mol Vis. 2007;13:1333-8 pubmed
    To describe a family with primary congenital cataract associated with a CRYGC mutation. One family with several affected members with primary congenital cataract and 170 healthy controls were examined...
  8. Yao K, Jin C, Zhu N, Wang W, Wu R, Jiang J, et al. A nonsense mutation in CRYGC associated with autosomal dominant congenital nuclear cataract in a Chinese family. Mol Vis. 2008;14:1272-6 pubmed
    ..The genomic DNA was extracted from peripheral blood leukocytes. All the exons and flanking intronic sequences of CRYGC and CRYGD were amplified by polymerase chain reaction (PCR) and screened for mutation by direct DNA sequencing...
  9. Zhang J, Yang A, Wu Y, Guan W, Xiong B, Peng X, et al. Stachydrine ameliorates carbon tetrachloride-induced hepatic fibrosis by inhibiting inflammation, oxidative stress and regulating MMPs/TIMPs system in rats. Biomed Pharmacother. 2018;97:1586-1594 pubmed publisher
    ..We aimed to evaluate the effect of STA on carbon tetrachloride (CCl4)-induced hepatic fibrosis in rats and to elucidate the possible mechanisms...
  10. Akbari B, Farajnia S, Ahdi Khosroshahi S, Safari F, Yousefi M, Dariushnejad H, et al. Immunotoxins in cancer therapy: Review and update. Int Rev Immunol. 2017;36:207-219 pubmed publisher
    ..growth factor; GM-CSF: granulocyte-macrophage colony-stimulating factor; DAB389: truncated Diphtheria toxin; B-CCL: B-cell chronic lymphocytic leukemia; RCC: renal cell carcinoma; GVHD: Graft-versus-host disease; EGFR: epidermal ..
  11. Kojima Yuasa A, Goto M, Yoshikawa E, Morita Y, Sekiguchi H, Sutoh K, et al. Protective Effects of Hydrolyzed Nucleoproteins from Salmon Milt against Ethanol-Induced Liver Injury in Rats. Mar Drugs. 2016;14: pubmed publisher
    ..were significantly less active in the DNSM-treated group than in the ethanol plus carbon tetrachloride (CCl?)-treated group...
  12. King A, Houlihan D, Kavanagh D, Haldar D, Luu N, Owen A, et al. Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis. Gastroenterology. 2017;153:233-248.e16 pubmed publisher
    ..Chronic liver injury was induced in BoyJ mice by injection of carbon tetrachloride (CCl4) or placement on a methionine-choline-deficient diet...
  13. Elßner C, Goeppert B, Longerich T, Scherr A, Stindt J, Nanduri L, et al. Nuclear Translocation of RELB Is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice. Gastroenterology. 2019;156:1190-1205.e14 pubmed publisher
    ..DDC) or standard chow diets to induce biliary injury or were given injections of CCl4 to induce non-cholestatic liver fibrosis...
  14. Abdullah -, Khan M, Ahmad W, Ahmad M, Nisar M. Hepatoprotective effect of the solvent extracts of Viola canescens Wall. ex. Roxb. against CCl4 induced toxicity through antioxidant and membrane stabilizing activity. BMC Complement Altern Med. 2017;17:10 pubmed publisher
    ..body weight) and partially purified EAF (50 mg/kg body weight) was investigated in carbon tetrachloride (CCl4) intoxicated BALB/c mice for 7 days...
  15. Choi Y, Choi J, Jang Y, Lee S, Lee S, Choi J, et al. Anti?inflammatory effect of Amomum xanthioides in a mouse atopic dermatitis model. Mol Med Rep. 2017;16:8964-8972 pubmed publisher
    ..of pro?inflammatory cytokines and chemokines, including TNF??, IL?1?, IL?6, IL?8, C?C motif chemokine ligand (CCL)17 and CCL22, as determined by RT?qPCR. However, upregulation of these genes was reduced by AXE pretreatment...
  16. Bhattacharya P, Dey R, Dagur P, Kruhlak M, Ismail N, Debrabant A, et al. Genetically Modified Live Attenuated Leishmania donovani Parasites Induce Innate Immunity through Classical Activation of Macrophages That Direct the Th1 Response in Mice. Infect Immun. 2015;83:3800-15 pubmed publisher
    ..interleukin-12 [IL-12], gamma interferon [IFN-γ], and IL-6), chemokines (monocyte chemoattractant protein 1/CCL-2, macrophage inflammatory protein 1α/CCL-3, and IP-10), reactive oxygen species (ROS), and nitric oxide, while ..
  17. Rathee D, Kamboj A, Sidhu S. Augmentation of hepatoprotective potential of Aegle marmelos in combination with piperine in carbon tetrachloride model in wistar rats. Chem Cent J. 2018;12:94 pubmed publisher
    ..marmelos (70% ethanol extract) in combination with piperine. The normal control and carbon tetrachloride (CCl4) administered rats were divided into 7 groups...
  18. Bakr R, El Naa M, Zaghloul S, Omar M. Profile of bioactive compounds in Nymphaea alba L. leaves growing in Egypt: hepatoprotective, antioxidant and anti-inflammatory activity. BMC Complement Altern Med. 2017;17:52 pubmed publisher
    ..O.) for 5 days was evaluated against CCl4-induced hepatotoxicity in male Wistar albino rats, in comparison with silymarin...
  19. Ali S, Khan M, Shah S, Batool R, Maryam S, Majid M, et al. Protective aptitude of Periploca hydaspidis Falc against CCl4 induced hepatotoxicity in experimental rats. Biomed Pharmacother. 2018;105:1117-1132 pubmed publisher
    ..of Periploca hydaspidis was assessed through various in vitro assays and by the hepatoprotective potential on CCl4 induced toxicity in rat. Phytochemical analysis of different extracts of P...
  20. Tian H, Liu L, Li Z, Liu W, Sun Z, Xu Y, et al. Chinese medicine CGA formula ameliorates liver fibrosis induced by carbon tetrachloride involving inhibition of hepatic apoptosis in rats. J Ethnopharmacol. 2019;232:227-235 pubmed publisher
    ..To evaluate the effects of CGA on hepatic apoptosis in liver fibrosis induced by carbon tetrachloride (CCl4). The hepatic injury and histology was detected by serum biomarker assay and hematoxylin-eosin staining...
  21. Kandimalla R, Dash S, Bhowal A, Kalita S, Talukdar N, Kundu S, et al. Glycogen-gold nanohybrid escalates the potency of silymarin. Int J Nanomedicine. 2017;12:7025-7038 pubmed publisher
    ..The fabricated nanohybrids showed significant protection against CCl4-induced hepatic injury in Wistar rats and maintained natural antioxidant (superoxide dismutase and ..
  22. Li Z, Yan Z, Lan F, Dong Y, Xiong Y. Suppression of NLRP3 inflammasome attenuates stress-induced depression-like behavior in NLGN3-deficient mice. Biochem Biophys Res Commun. 2018;: pubmed publisher
    ..TNF-?), interleukin-18 (IL-18), interleukin-1 beta (IL-1?), interleukin-4 (IL-4), CC-chemokine ligand-1 (CCL-1) and CXC-chemokine ligand-1 (CXCL-1), in cortex, hippocampus and amygdala tissue samples...
  23. An S, Jang Y, Lim H, Han J, Lee J, Lee G, et al. Milk Fat Globule-EGF Factor 8, Secreted by Mesenchymal Stem Cells, Protects Against Liver Fibrosis in Mice. Gastroenterology. 2017;152:1174-1186 pubmed publisher
    ..Liver fibrosis was induced in mice by intraperitoneal injection of thioacetamide or CCl4; some mice were then given injections of secretomes or proteins...
  24. Zhan Y, Wang J, Tian X, Feng S, Xue L, Tian L. Protective effects of seed melon extract on CCl4-induced hepatic fibrosis in mice. J Ethnopharmacol. 2016;193:531-537 pubmed publisher
    ..vulgaris var. megalaspermus Lin et Chao) extract (SME) against carbon tetrachloride (CCl4) induced hepatic fibrosis in mice...
  25. Zhang C, Zheng L, Gui L, Lin J, Zhu Y, Deng W, et al. Soluble epoxide hydrolase inhibition with t-TUCB alleviates liver fibrosis and portal pressure in carbon tetrachloride-induced cirrhosis in rats. Clin Res Hepatol Gastroenterol. 2018;42:118-125 pubmed publisher
    ..The models were established by CCl4 (2ml/kg) given subcutaneously for 14 weeks...
  26. Song Z, Si N, Xiao W. A novel mutation in the CRYAA gene associated with congenital cataract and microphthalmia in a Chinese family. BMC Med Genet. 2018;19:190 pubmed publisher
    ..All coding exons and flanking regions of seven candidate genes (CRYAA, CRYBA4, CRYBB2, CRYGC, GJA8, MAF, and PITX3) were amplified and sequenced...
  27. Zhang Y, Guo H, Cheng B, Su T, Fu X, Li T, et al. Dingchuan tang essential oil inhibits the production of inflammatory mediators via suppressing the IRAK/NF-κB, IRAK/AP-1, and TBK1/IRF3 pathways in lipopolysaccharide-stimulated RAW264.7 cells. Drug Des Devel Ther. 2018;12:2731-2748 pubmed publisher
    ..factor-α [TNF-α]), and chemokines (monocyte chemoattractant protein-1 [MCP-1], chemokine [C-C motif] ligand 5 [CCL-5], and macrophage inflammatory protein [MIP]-1α) were suppressed by DCEO treatment...
  28. Cao W, Ge J, Xie X, Fan M, Fan X, Wang H, et al. Protective effects of petroleum ether extracts of Herpetospermum caudigerum against ?-naphthylisothiocyanate-induced acute cholestasis of rats. J Ethnopharmacol. 2017;198:139-147 pubmed publisher
    ..caudigerum exhibited protective effects against carbon tetrachloride (CCl4)-induced hepatic damage in rats, which may be related to their free radical scavenging effect...
  29. Hariharapura R, Srinivasan R, Ashok G, Dongre S, Jagani H, Vijayan P. Investigation of the Antioxidant and Hepatoprotective Potential of Hypericum mysorense. Antioxidants (Basel). 2014;3:526-43 pubmed publisher
    ..alanine amino transferase (ALAT), alkaline phosphatase (ALP), total bilirubin and protein levels significantly in CClâ‚„-intoxicated rats. The tested extracts also showed a significant (p < 0...
  30. Fernando N, Natoli R, Valter K, Provis J, Rutar M. The broad-spectrum chemokine inhibitor NR58-3.14.3 modulates macrophage-mediated inflammation in the diseased retina. J Neuroinflammation. 2016;13:47 pubmed publisher
    ..Here, we examine the efficacy of the broad-spectrum chemokine inhibitor NR58-3.14.3-a suppressor of Ccl- and Cxcl- chemokine pathways-in suppressing macrophage activity and photoreceptor death, using a light-induced ..
  31. Xue L, Geng Y, Li M, Jin Y, Ren H, Li X, et al. The effects of D3R on TLR4 signaling involved in the regulation of METH-mediated mast cells activation. Int Immunopharmacol. 2016;36:187-198 pubmed publisher
    ..We also measured the production of MC-derived cytokines, including TNF-?, IL-6, IL-4, IL-13 and CCL-5, in the bone marrow-derived mast cells (BMMCs) of WT and D3R(-/-) mice...
  32. Wang P, Gao Y, Sun X, Guo N, Li J, Wang W, et al. Hepatoprotective effect of 2'-O-galloylhyperin against oxidative stress-induced liver damage through induction of Nrf2/ARE-mediated antioxidant pathway. Food Chem Toxicol. 2017;102:129-142 pubmed publisher
    ..Meanwhile, histopathological evaluation of the liver also revealed that 2'-O-GH effectively ameliorated CCl4-induced the hepatic damage by reducing alanine aminotransferase (ALT) and aspartate aminotransferase (..
  33. Lewis K, Hall J, Kiyotake E, Christensen T, Balasubramaniam V, Anseth K. Epithelial-mesenchymal crosstalk influences cellular behavior in a 3D alveolus-fibroblast model system. Biomaterials. 2018;155:124-134 pubmed publisher
    ..A fibroblast cell line (CCL-210) was co-cultured with either healthy mouse alveolar epithelial primary cells or a cancerous alveolar epithelial ..
  34. Tang N, Sun B, Gupta A, Rempel H, Pulliam L. Monocyte exosomes induce adhesion molecules and cytokines via activation of NF-?B in endothelial cells. FASEB J. 2016;30:3097-106 pubmed publisher
    ..or I/L Exos were added to HUVECs, we found a significant increase in adhesion molecule ICAM-1, chemokine ligand (CCL)-2, and cytokine IL-6 mRNAs and proteins compared with cells treated with IFN? Exos or Exos derived from ..
  35. Lin H, Zhang X, Shen Y, Zheng Y, Guo Y, Zhu Y, et al. Model-dependent and model-independent approaches for evaluating hepatic fibrosis in rat liver using shearwave dispersion ultrasound vibrometry. Med Eng Phys. 2017;39:66-72 pubmed publisher
    ..Liver fibrosis was induced in 37 rats using carbon tetrachloride (CCl4); 6 rats served as the controls...
  36. Zhu X, Sun Y, Mu X, Guo P, Gao F, Zhang J, et al. Phospholipase C? deficiency delays the early stage of cutaneous wound healing and attenuates scar formation in mice. Biochem Biophys Res Commun. 2017;484:144-151 pubmed publisher
    ..of interleukin (IL)-6, chemokine (C-X-C motif) ligand (Cxcl)-1, Cxcl-2, and chemokine (C-C motif) ligand (Ccl) 20...
  37. Zhan W, Liao X, Tian T, Yu L, Liu X, Li B, et al. Study on the effects of blueberry treatment on histone acetylation modification of CCl4-induced liver disease in rats. Genet Mol Res. 2017;16: pubmed publisher
    ..was to investigate the effects of blueberry treatment on histone acetylation modification of carbon tetrachloride (CCl4)-induced liver disease in rats...
  38. Kokanova Nedialkova Z, Nedialkov P, Kondeva Burdina M, Simeonova R, Tzankova V, Aluani D. Chenopodium bonus-henricus L. - A source of hepatoprotective flavonoids. Fitoterapia. 2017;118:13-20 pubmed publisher
    ..complex silymarin in in vitro (60?g/mL) and in vivo (100mg/kg/daily for 7days) models of hepatotoxicity, induced by CCl4...
  39. Lin Y, Kuang Y, Li K, Wang S, Ji S, Chen K, et al. Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl4-induced liver injury in mice. Bioorg Med Chem. 2017;25:5522-5530 pubmed publisher
    ..17-fold), and 19 (echinatin, 4.09-fold). Further studies indicated that 11, 12 and 19 remarkably attenuated CCl4-induced acute liver injury in mice (10 or 50mg/kg, 7days, ig.)...
  40. Du K, Hyun J, Premont R, Choi S, Michelotti G, Swiderska Syn M, et al. Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells. Gastroenterology. 2018;154:1465-1479.e13 pubmed publisher
    ..Acute and chronic liver fibrosis were induced in mice by intraperitoneal injection of CCl4 or methionine choline-deficient diet...
  41. Al Faraj A, Shaik A, Shaik A. Effect of surface coating on the biocompatibility and in vivo MRI detection of iron oxide nanoparticles after intrapulmonary administration. Nanotoxicology. 2015;9:825-34 pubmed publisher
    ..Genotoxicity assessments revealed an increase in DNA damage and gene expression of CCL-17 and IL-10 biomarkers following SPIONs administration, which was significantly higher than surface-modified ..
  42. Jiang B, Xue M. Correlation of E6 and E7 levels in high-risk HPV16 type cervical lesions with CCL20 and Langerhans cells. Genet Mol Res. 2015;14:10473-81 pubmed publisher
    The human papillomavirus (HPV)16 E6 and E7 correlation with chemokine ligand (CCL)20 expression and Langerhans cells (LCs) in cervical lesions was investigated...
  43. Huang W, Chen C, Wu S. Almond Skin Polyphenol Extract Inhibits Inflammation and Promotes Lipolysis in Differentiated 3T3-L1 Adipocytes. J Med Food. 2017;20:103-109 pubmed publisher
    ..The proinflammatory mediators monocyte chemotactic protein-1 (MCP-1) and chemokine ligand 5 (CCL-5) were determined by enzyme-linked immunosorbent assay...
  44. Wu H, Yao S, Zhang S, Wang J, Guo P, Li X, et al. Elevated expression of Erbin destabilizes ERα protein and promotes tumorigenesis in hepatocellular carcinoma. J Hepatol. 2017;66:1193-1204 pubmed publisher
    ..Animal models of diethylnitrosamine (DEN) or DEN/CCl4-induced HCC in wild-type Erbin+/+ and mutant ErbinΔC/ΔC mice were observed...
  45. Tsai J, Chiu C, Chen Y, Lee M, Hao X, Hsieh M, et al. Hepatoprotective effect of Coreopsis tinctoria flowers against carbon tetrachloride-induced liver damage in mice. BMC Complement Altern Med. 2017;17:139 pubmed publisher
    ..tinctoria (CTEtOH) using an animal model of carbon tetrachloride (CCl4)-induced acute liver injury. CTEtOH (0.5 and 1...
  46. Fu Q, Yang Y, Li C, Zeng Q, Zhou T, Li N, et al. The chemokinome superfamily: II. The 64 CC chemokines in channel catfish and their involvement in disease and hypoxia responses. Dev Comp Immunol. 2017;73:97-108 pubmed publisher
    ..In this study, a complete set of 64 CC chemokine ligand (CCL) genes was systematically identified, annotated, and characterized from the channel catfish genome...
  47. Zhao Z, Liu H, Sun X, Guo T, Shen L, Tao Y, et al. Levistilide A inhibits angiogenesis in liver fibrosis via vascular endothelial growth factor signaling pathway. Exp Biol Med (Maywood). 2017;242:974-985 pubmed publisher
    ..To verify the results in vivo, rats were subcutaneously injected with CCl4 twice a week for six weeks to duplicate the liver fibrosis model and then treated with 10?mL/kg of ..
  48. Hu J, Wang H, Pan C, Lin M. Isovitexin alleviates liver injury induced by lipopolysaccharide/d-galactosamine by activating Nrf2 and inhibiting NF-κB activation. Microb Pathog. 2018;119:86-92 pubmed publisher
    ..Isovitexin also had protective effects against carbon tetrachloride (CCl4)-induced liver injury. Isovitexin may used as a potential agent for the treatment of liver injury.
  49. Yeh K, Chiu C, Su K, Tsai M, Hua M, Liao S, et al. High cord blood CCL22/CXCL10 chemokine ratios precede allergic sensitization in early childhood. Oncotarget. 2017;8:7384-7390 pubmed publisher
    ..The Th1-associated CXC chemokine ligand (CXCL)-10, CXCL11, and the Th2-associated CC chemokine ligand (CCL)-17 and CCL22 were quantified in cord blood by multiplex Luminex kits...
  50. Wang L, Lu J, Sun W, Gu Y, Zhang C, Jin R, et al. Hepatotoxicity induced by radix Sophorae tonkinensis in mice and increased serum cholinesterase as a potential supplemental biomarker for liver injury. Exp Toxicol Pathol. 2017;69:193-202 pubmed publisher
    ..1% and 0.2% carbon tetrachloride (CCl4)...
  51. Nandi A, Bishayi B. CCR-2 neutralization augments murine fresh BMC activation by Staphylococcus aureus via two distinct mechanisms: at the level of ROS production and cytokine response. Innate Immun. 2017;23:345-372 pubmed publisher
    ..We sought to determine whether CCL-2/CCR-2 signaling is involved in the killing of Staphylococcus aureus by murine bone marrow cells (BMCs)...
  52. Hong Y, Liu S, Huang C, Xia L, Shen C, Jiang H, et al. Simultaneous Improvement of Resolving Power and Signal-to-Noise Ratio Using a Modified Hadamard Transform-Inverse Ion Mobility Spectrometry Technique. J Am Soc Mass Spectrom. 2017;28:2500-2507 pubmed publisher
    ..Furthermore, the gas sample CCl4 and CHCl3 were measured for evaluating the capability of detecting those samples which have ..
  53. Habiyaremye G, Morales D, Morgan C, Mcallister J, CreveCoeur T, Han R, et al. Chemokine and cytokine levels in the lumbar cerebrospinal fluid of preterm infants with post-hemorrhagic hydrocephalus. Fluids Barriers CNS. 2017;14:35 pubmed publisher
    ..levels of key cytokines (IL-1?, IL-1?, IL-4, IL-6, IL-8, IL-10, IL-12, TNF-?, TGF-?1, IFN-?) and chemokines (XCL-1, CCL-2, CCL-3, CCL-19, CXCL-10, CXCL-11, CXCL-12) were measured using conventional and multiplexed Enzyme-linked ..
  54. Jiang J, Shi Y, Yu R, Chen L, Zhao X. Biological response of zebrafish after short-term exposure to azoxystrobin. Chemosphere. 2018;202:56-64 pubmed publisher
    ..bbc3, cas8 and cas9 involved in cell apoptosis, and the mRNA levels of cytokines and chemokines such as cxcl-c1c, ccl, il-1?, il-8, ifn, and tnf? were in accordance with the trends of the examined genes involved in oxidative stress ..
  55. Shi H, Shi A, Dong L, Lu X, Wang Y, Zhao J, et al. Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress. Clin Nutr. 2016;35:1366-1373 pubmed publisher
    ..Our former studies suggested that CGA could prevent CCl4-induced liver fibrosis through inhibition of inflammatory signaling pathway in rats...
  56. De Veirman K, Wang J, Xu S, Leleu X, Himpe E, Maes K, et al. Induction of miR-146a by multiple myeloma cells in mesenchymal stromal cells stimulates their pro-tumoral activity. Cancer Lett. 2016;377:17-24 pubmed publisher
    ..miR-146a in MSC, secretion of several cytokines and chemokines including CXCL1, IL6, IL-8, IP-10, MCP-1, and CCL-5 was elevated, resulting in the enhancement of MM cell viability and migration...
  57. Lazarova I, Simeonova R, Vitcheva V, Kondeva Burdina M, Gevrenova R, Zheleva Dimitrova D, et al. Hepatoprotective and antioxidant potential of Asphodeline lutea (L.) Rchb. roots extract in experimental models in vitro/in vivo. Biomed Pharmacother. 2016;83:70-78 pubmed publisher
    ..Rchb. dry root extract (ALE) administered alone and against carbon tetrachloride (CCl4)-induced liver injury in vitro/in vivo. The dried roots of A...
  58. Su H, Lin H, Suen J, Sheu C, Yokoyama K, Huang S, et al. Aryl hydrocarbon receptor-ligand axis mediates pulmonary fibroblast migration and differentiation through increased arachidonic acid metabolism. Toxicology. 2016;370:116-126 pubmed publisher
    ..on pulmonary fibroblast migration and differentiation was analyzed using human primary lung fibroblasts HFL-1 and CCL-202 cells...
  59. Kubin M, Kokkonen N, Palatsi R, Hägg P, Väyrynen J, Glumoff V, et al. Clinical Efficiency of Topical Calcipotriol/Betamethasone Treatment in Psoriasis Relies on Suppression of the Inflammatory TNF? - IL-23 - IL-17 Axis. Acta Derm Venereol. 2017;97:449-455 pubmed publisher
    ..therapy down-regulated the expression of tumour necrosis factor (TNF)-?, interleukin (IL)-23A, IL-17A, S100A7, CCL-20 and interferon (IFN)-? in skin and TNF-?, IL-6, IL-23A, T-bet and IFN-? in peripheral blood mononuclear cells (..
  60. Wu L, Qiu W, Sun J, Wang J. SENP1 attenuates the liver fibrosis through down-regulating the expression of SMAD2. Biochem Biophys Res Commun. 2018;495:755-760 pubmed publisher
    ..SD) rats were used to establish the liver fibrosis rat models by intraperitoneally injecting with 1 ml/kg of 10% CCl4, while the control normal rats were injected with olive oil...
  61. Meakin S, Breitman M, Tsui L. Structural and evolutionary relationships among five members of the human gamma-crystallin gene family. Mol Cell Biol. 1985;5:1408-14 pubmed
    ..7 to 4.5 kilobases. At least one of the two pseudogenes appears to have been functional before inactivation, suggesting that their identical mutation was generated by gene conversion. ..
  62. Kondo Y, Saitsu H, Miyamoto T, Lee B, Nishiyama K, Nakashima M, et al. Pathogenic mutations in two families with congenital cataract identified with whole-exome sequencing. Mol Vis. 2013;19:384-9 pubmed
    ..WES readily identified a CRYAA mutation in family A and a CRYGC mutation in family B. The c.61C>T (p...
  63. Shindo S, Hosokawa Y, Hosokawa I, Ozaki K, Matsuo T. Shikonin Inhibits Inflammatory Cytokine Production in Human Periodontal Ligament Cells. Inflammation. 2016;39:1124-9 pubmed publisher
    ..shikonin is able to influence the production of interleukin (IL)-6, IL-8, and/or chemokine C-C motif ligand (CCL)20, which contribute to the pathogenesis of periodontal disease, in human periodontal ligament cells (HPDLC)...
  64. Brison M, LeTallec Y. Transforming cold chain performance and management in lower-income countries. Vaccine. 2017;35:2107-2109 pubmed publisher
    ..limiting full and equitable access to effective immunization is the existence of gaps in cold chain and logistics (CCL) systems...
  65. Kraus A, Penna Martinez M, Meyer G, Badenhoop K. Vitamin D effects on monocytes' CCL-2, IL6 and CD14 transcription in Addison's disease and HLA susceptibility. J Steroid Biochem Mol Biol. 2018;177:53-58 pubmed publisher
    ..potential anti-inflammatory vitamin D effects on monocytes in Addison's disease, focusing on inflammatory CCL-2 and IL6, as well on monocyte CD14 markers...
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    ..macrophages in an environment presenting a variety of pro-inflammatory mediators (IFN-γ, IL-1β, CXCL-10/CXCR-3, CCL-7/CCR-2), but with an intense anti-inflammatory response, led by IL-10; and a re-inflammation phase three months ..
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  78. Yu F, Jiang Z, Chen B, Dong P, Zheng J. NEAT1 accelerates the progression of liver fibrosis via regulation of microRNA-122 and Kruppel-like factor 6. J Mol Med (Berl). 2017;95:1191-1202 pubmed publisher
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  79. Devarapu S, Kumar Vr S, Rupanagudi K, Kulkarni O, Eulberg D, Klussmann S, et al. Reprint of "Dual blockade of the pro-inflammatory chemokine CCL2 and the homeostatic chemokine CXCL12 is as effective as high dose cyclophosphamide in murine proliferative lupus nephritis". Clin Immunol. 2017;185:119-127 pubmed publisher
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    ..Sixty mice were randomly divided into six groups: control group [without carbon tetrachloride (CCl4) or APSPE]; model group (with CCl4 only); positive control group (50 mg/kg body weight ..
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    ..Both activities could modify the cataract phenotype and help explain the observed variability reported for identical gamma-crystallin mutations, which identify cataract as a polygenic disease. ..
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    ..Cirrhosis in mice was induced by CCl4 A transgenic mouse expressing a red fluorescent protein reporter under the control of Tie2 promoter (..
  91. Yannopoulos D, Bartos J, Raveendran G, Conterato M, Frascone R, Trembley A, et al. Coronary Artery Disease in Patients With Out-of-Hospital Refractory Ventricular Fibrillation Cardiac Arrest. J Am Coll Cardiol. 2017;70:1109-1117 pubmed publisher
    ..VF/VT cardiac arrest treated with a novel protocol of early transport to a cardiac catheterization laboratory (CCL) for extracorporeal life support (ECLS) and revascularization...
  92. Feng G, Li J, Yang Z, Zhang S, Liu Y, Zhang W, et al. Hepatitis B virus X protein promotes the development of liver fibrosis and hepatoma through downregulation of miR-30e targeting P4HA2 mRNA. Oncogene. 2017;36:6895-6905 pubmed publisher
    ..HBV transgenic mouse was treated by CCl4 to generate a model of liver fibrosis...