CRX

Summary

Gene Symbol: CRX
Description: cone-rod homeobox
Alias: CORD2, CRD, LCA7, OTX3, cone-rod homeobox protein, orthodenticle homeobox 3
Species: human

Top Publications

  1. ncbi De novo mutations in the CRX homeobox gene associated with Leber congenital amaurosis
    C L Freund
    Nat Genet 18:311-2. 1998
  2. ncbi Leber congenital amaurosis caused by a homozygous mutation (R90W) in the homeodomain of the retinal transcription factor CRX: direct evidence for the involvement of CRX in the development of photoreceptor function
    A Swaroop
    Department of Ophthalmology, Program in Cellular and Molecular Biology, W K Kellogg Eye Center, University of Michigan, Ann Arbor, MI 48105 0714, USA
    Hum Mol Genet 8:299-305. 1999
  3. ncbi Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes
    S Chen
    The Wilmer Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Neuron 19:1017-30. 1997
  4. ncbi Barrier to autointegration factor interacts with the cone-rod homeobox and represses its transactivation function
    Xuejiao Wang
    Department of Ophthalmology and Visual Sciences, Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:43288-300. 2002
  5. ncbi Mutations in the cone-rod homeobox gene are associated with the cone-rod dystrophy photoreceptor degeneration
    P K Swain
    Department of Ophthalmology, W K Kellogg Eye Center, University of Michigan, Ann Arbor 48105, USA
    Neuron 19:1329-36. 1997
  6. ncbi Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development
    L C Bibb
    Section of Cell and Molecular Biology, Imperial College School of Medicine, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, UK
    Hum Mol Genet 10:1571-9. 2001
  7. ncbi Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor
    C L Freund
    Department of Genetics, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    Cell 91:543-53. 1997
  8. ncbi The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes
    Guang Hua Peng
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 14:747-64. 2005
  9. doi The effectiveness and cost-effectiveness of cochlear implants for severe to profound deafness in children and adults: a systematic review and economic model
    M Bond
    Peninsula Technology Assessment Group PenTAG, Peninsula Medical School, Universities of Exeter and Plymouth, UK
    Health Technol Assess 13:1-330. 2009
  10. ncbi Nucleic acid is a novel ligand for innate, immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin
    Nades Palaniyar
    MRC Immunochemistry Unit, Department of Biochemistry, The University of Oxford, Oxford OX1 3QU, United Kingdom
    J Biol Chem 279:32728-36. 2004

Research Grants

  1. PATHOGENESIS OF ACANTHAMOEBA KERATITIS
    Noorjahan Panjwani; Fiscal Year: 2010
  2. ENHANCING COLLECTIN MEDIATED HOST DEFENSE
    Kevan Hartshorn; Fiscal Year: 2001
  3. ADHERENCE BLOCKING VACCINE FOR AMEBIASIS
    William Petri; Fiscal Year: 2003
  4. Field Studies of Human Immunity to Amebiasis in Bangladesh
    William Petri; Fiscal Year: 2007
  5. PATHOGENESIS OF ACANTHAMOEBA KERATITIS
    Noorjahan Panjwani; Fiscal Year: 2011
  6. Mechanisms of social-stress enhanced allergic airway response in a mouse model
    Angela Haczku; Fiscal Year: 2010
  7. SCA7 RETINAL DEGENERATION: MOLECULAR BASIS & THERAPY
    Albert La Spada; Fiscal Year: 2006
  8. NEUROCHEMICAL MECHANISMS OF VISCERAL PAIN
    Richard J Traub; Fiscal Year: 2010
  9. NEUROCHEMICAL MECHANISMS OF VISCERAL PAIN
    RICHARD TRAUB; Fiscal Year: 2009
  10. Metabolism of Endothelial Dysfunction in Renal Disease
    Leticia Castillo; Fiscal Year: 2005

Detail Information

Publications159 found, 100 shown here

  1. ncbi De novo mutations in the CRX homeobox gene associated with Leber congenital amaurosis
    C L Freund
    Nat Genet 18:311-2. 1998
  2. ncbi Leber congenital amaurosis caused by a homozygous mutation (R90W) in the homeodomain of the retinal transcription factor CRX: direct evidence for the involvement of CRX in the development of photoreceptor function
    A Swaroop
    Department of Ophthalmology, Program in Cellular and Molecular Biology, W K Kellogg Eye Center, University of Michigan, Ann Arbor, MI 48105 0714, USA
    Hum Mol Genet 8:299-305. 1999
    The CRX (cone-rod homeobox) gene is specifically expressed in developing and mature photoreceptors and encodes an otd/Otx-like paired homeodomain protein...
  3. ncbi Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes
    S Chen
    The Wilmer Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Neuron 19:1017-30. 1997
    ..a bait containing the Ret 4 site from the bovine rhodopsin promoter, we have cloned a new member of the family, Crx (Cone rod homeobox)...
  4. ncbi Barrier to autointegration factor interacts with the cone-rod homeobox and represses its transactivation function
    Xuejiao Wang
    Department of Ophthalmology and Visual Sciences, Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:43288-300. 2002
    b>Crx (cone-rod homeobox) is a homeodomain transcription factor implicated in regulating the expression of photoreceptor and pineal genes...
  5. ncbi Mutations in the cone-rod homeobox gene are associated with the cone-rod dystrophy photoreceptor degeneration
    P K Swain
    Department of Ophthalmology, W K Kellogg Eye Center, University of Michigan, Ann Arbor 48105, USA
    Neuron 19:1329-36. 1997
    b>Crx is a novel paired-like homeodomain protein that is expressed predominantly in retinal photoreceptors and pinealocytes. Its gene has been mapped to chromosome 19q13...
  6. ncbi Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development
    L C Bibb
    Section of Cell and Molecular Biology, Imperial College School of Medicine, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, UK
    Hum Mol Genet 10:1571-9. 2001
    Cone--rod homeobox (CRX), a paired-like homeobox transcription factor, plays a major role in photoreceptor development and maintenance of the retina...
  7. ncbi Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor
    C L Freund
    Department of Genetics, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    Cell 91:543-53. 1997
    ..homeodomain transcription factor gene (CRX) cause an autosomal dominant form of cone-rod dystrophy (adCRD) at the CORD2 locus on chromosome 19q13...
  8. ncbi The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes
    Guang Hua Peng
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 14:747-64. 2005
    ..Using yeast two-hybrid screens with Nr2e3 as bait, the cone-rod homeobox protein Crx was identified as an interacting partner of Nr2e3...
  9. doi The effectiveness and cost-effectiveness of cochlear implants for severe to profound deafness in children and adults: a systematic review and economic model
    M Bond
    Peninsula Technology Assessment Group PenTAG, Peninsula Medical School, Universities of Exeter and Plymouth, UK
    Health Technol Assess 13:1-330. 2009
    ....
  10. ncbi Nucleic acid is a novel ligand for innate, immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin
    Nades Palaniyar
    MRC Immunochemistry Unit, Department of Biochemistry, The University of Oxford, Oxford OX1 3QU, United Kingdom
    J Biol Chem 279:32728-36. 2004
    ..recombinant fragments of SP-D that are composed of the alpha-helical coiled-coil neck region and three CRDs (SP-D(n/CRD)) or SP-D(n/CRD) with eight GXY repeats (SPD(GXY)(8)(n/CRD))...
  11. pmc Effects of azithromycin in combination with vancomycin, daptomycin, fosfomycin, tigecycline, and ceftriaxone on Staphylococcus epidermidis biofilms
    Elisabeth Presterl
    Department of Medicine I, Division of Infectious Diseases, Medical University of Vienna, Allgemeines Krankenhaus, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Antimicrob Agents Chemother 53:3205-10. 2009
    ..the effects of vancomycin (VAN), daptomycin (DAP), fosfomycin (FOS), tigecycline (TGC), and ceftriaxone (CRX), alone and in combination with azithromycin (AZI), on established biofilms of Staphylococcus epidermidis...
  12. pmc Informative value of Patient Reported Outcomes (PRO) in Health Technology Assessment (HTA)
    Christian Brettschneider
    University Medical Center Hamburg Eppendorf, Department of Medical Sociology and Health Economics, Hamburg, Germany
    GMS Health Technol Assess 7:Doc01. 2011
    ..The search for HTA-reports and methodological papers of HTA-agencies was performed in the CRD-Databases (CRD = Centre for Reviews and Dissemination) and by handsearching the websites of INAHTA member agencies (..
  13. ncbi The early effects of dietary restriction on the pathogenesis of chronic renal disease in Sprague-Dawley rats at 12 months
    L A Gumprecht
    Department of Veterinary Pathobiology, University of Illinois College of Veterinary Medicine, Urbana 61801
    Toxicol Pathol 21:528-37. 1993
    ..study evaluated the effects of different diets and dietary regimens on the pathogenesis of chronic renal disease (CRD) in Sprague-Dawley rats at 52 wk and correlated these data with survival at 106 wk...
  14. ncbi The second glutamic acid in the C-terminal CRD affects the carbohydrate-binding properties of recombinant galectins of Haemonchus contortus
    Jing Wang
    College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China
    Vet Parasitol 148:247-55. 2007
    ..The second E in the CRD, WGNEER, of Hco-GAL-m was mutated to glycine acid (G) and resulted in a recombinant galectin (MG mutate) with a CRD ..
  15. pmc Galectin multimerization and lattice formation are regulated by linker region structure
    Lesley A Earl
    Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Glycobiology 21:6-12. 2011
    ..Prototype galectins, such as galectin-1, are one carbohydrate recognition domain (CRD) monomers that noncovalently dimerize, whereas tandem-repeat galectins, such as galectin-9, have two non-identical ..
  16. ncbi The primary structure and carbohydrate specificity of a beta-galactosyl-binding lectin from toad (Bufo arenarum Hensel) ovary reveal closer similarities to the mammalian galectin-1 than to the galectin from the clawed frog Xenopus laevis
    H Ahmed
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21202, USA
    J Biol Chem 271:33083-94. 1996
    ..exhibited the highest identity (48% for the whole molecule and 77% for the carbohydrate recognition domain (CRD)) with the bovine spleen galectin-1, but surprisingly less identity (38% for the whole molecule and 47% for the CRD)..
  17. ncbi Expression of Mycobacterium leprae 18-kDa antigen in yeast in a GPI-anchored form
    A G Amorim
    Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, , Brasil
    Braz J Med Biol Res 27:623-6. 1994
    ..In addition, these cells react with an alpha-CRD antibody after GPI-PLC treatment. The non-transformed cells are negative...
  18. pmc Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa
    Sara J Bowne
    Human Genetics Center, School of Public Health, The University of Texas HSC, Houston, TX 77030, USA
    Hum Mol Genet 11:559-68. 2002
    ..A screen of retinal transcripts comparing retinas from normal mice to retinas from crx-/crx- knockout mice (with poorly differentiated photoreceptors) demonstrated a 6-fold reduction in one candidate, ..
  19. pmc Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency
    Gareth G Lavery
    Division of Medical Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 93:3827-32. 2008
    Cortisone reductase deficiency (CRD) is characterized by a failure to regenerate cortisol from cortisone via 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), resulting in increased cortisol clearance, activation of the ..
  20. ncbi Delayed expression of the Crx gene and photoreceptor development in the Chx10-deficient retina
    Adam D Rutherford
    Developmental Biology Unit, Institute of Child Health, University College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 45:375-84. 2004
    ..The purpose of this study was to examine how neuronal development is affected by absence of the Chx10 transcription factor in the mouse retina...
  21. pmc Guidelines for the diagnosis and management of chylomicron retention disease based on a review of the literature and the experience of two centers
    Noel Peretti
    Department of Nutrition, CHU Sainte Justine Research Center, Universite de Montreal, 3175, Ste Catherine Road, Montreal, Quebec, H3T 1C5, Canada
    Orphanet J Rare Dis 5:24. 2010
    ..Familial hypocholesterolemia, namely abetalipoproteinemia, hypobetalipoproteinemia and chylomicron retention disease (CRD), are rare genetic diseases that cause malnutrition, failure to thrive, growth failure and vitamin E deficiency, as ..
  22. ncbi Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels
    Eleonora Distrutti
    University of Perugia, Clinica di Gastroenterologia, Policlinico Monteluce, Via Enrico Dal Pozzo, 06122 Perugia, Italy
    J Pharmacol Exp Ther 316:325-35. 2006
    ..rats (healthy and postcolitic), and rectal nociception was assessed by measuring the behavioral response during CRD. Healthy rats were administered with sodium hydrogen sulfide (NaHS) (as a source of H(2)S), L-cysteine, or vehicle...
  23. doi PmLT, a C-type lectin specific to hepatopancreas is involved in the innate defense of the shrimp Penaeus monodon
    Tracy Hoi Tung Ma
    School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China
    J Invertebr Pathol 99:332-41. 2008
    ..Unlike the other two P. monodon lectin-like proteins described to date that have one CRD, PmLT has two CRDs...
  24. pmc Genomic organization of zebrafish cone-rod homeobox gene and exclusion as a candidate gene for retinal degeneration in niezerka and mikre oko
    Deborah C Otteson
    Guerrieri Center for Genetic Engineering and Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Mol Vis 11:986-95. 2005
    To determine the genomic organization of the zebrafish crx gene and to evaluate if mutations in crx are responsible for the retinal degeneration phenotype in the zebrafish (Danio rerio) mutants niezerka (nie(m743)) and mikre oko (mok(..
  25. ncbi Equine trypanosomosis in the Central River Division of The Gambia: a study of veterinary gate-clinic consultation records
    S Dhollander
    International Trypanotolerance Centre, PMB 14 Banjul, The Gambia
    Prev Vet Med 75:152-62. 2006
    ..of this study was to provide epidemiological information of equine trypanosomosis in the Central River Division (CRD) of The Gambia...
  26. ncbi A study of the hexose-6-phosphate dehydrogenase gene R453Q and 11beta-hydroxysteroid dehydrogenase type 1 gene 83557insA polymorphisms in the polycystic ovary syndrome
    Jose L San Millan
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9 1, E 28034 Madrid, Spain
    J Clin Endocrinol Metab 90:4157-62. 2005
    ..83557insA mutations in 11beta-hydroxysteroid dehydrogenase (11betaHSD) type 1 gene (HSD11B1) interact, resulting in cortisone reductase deficiency (CRD), a rare disorder characterized by a polycystic ovary syndrome (PCOS)-like phenotype.
  27. ncbi Colonic inflammation induces fos expression in the thoracolumbar spinal cord increasing activity in the spinoparabrachial pathway
    Richard J Traub
    Department of Oral and Craniofacial Biological Sciences, Dental School, University of Maryland, 666 W Baltimore Street, Baltimore, MD 21201, USA
    Pain 95:93-102. 2002
    ..In the rat, repetitive noxious colorectal distention (CRD) induces >200 Fos labeled cells per section in the lumbosacral segments, but few in the thoracolumbar segments, ..
  28. ncbi [Work capacity in patients on hemodialysis]
    Lidija Orlic
    Klinika za internu medicinu Klinicki bolnicki centar Rijeka T Strizića 3 51000 Rijeka, Hrvatska
    Acta Med Croatica 58:67-71. 2004
    ..During the progression of chronic renal disease (CRD) to terminal renal failure (TRF) physical activity of the patients becomes poorer...
  29. ncbi Efficacy and tolerability of intravenous continuous erythropoietin receptor activator: a 19-week, phase II, multicenter, randomized, open-label, dose-finding study with a 12-month extension phase in patients with chronic renal disease
    Anatole Besarab
    Division of Nephrology and Hypertension, Department o f Medicine, Henry Ford Hospital, Detroit, Michigan, USA
    Clin Ther 29:626-39. 2007
    A continuous erythropoietin receptor activator (C.E.R.A.) is currently in development for the treatment of anemia in patients with chronic renal disease (CRD) receiving or not receiving dialysis treatment.
  30. ncbi Clinical findings in early onset cone-rod dystrophy in the Standard Wire-haired Dachshund
    Ernst O Ropstad
    Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway
    Vet Ophthalmol 10:69-75. 2007
    To describe the clinical findings and the age of onset of cone-rod dystrophy (crd) in the Standard Wire-haired Dachshund (SWHD) and to evaluate which clinical tests could be used to obtain a reliable diagnosis.
  31. ncbi Mechanism of Ca2+ and monosaccharide binding to a C-type carbohydrate-recognition domain of the macrophage mannose receptor
    N P Mullin
    Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 272:5668-81. 1997
    ..has been used to identify residues that ligate Ca2+ and sugar to the fourth C-type carbohydrate-recognition domain (CRD) of the macrophage mannose receptor...
  32. doi Effect of dietary organic and inorganic micromineral source and level on sow body, liver, colostrum, mature milk, and progeny mineral compositions over six parities
    J C Peters
    The Ohio Agricultural Research and Development Center, The Ohio State University, Columbus 43210 1095, Ohio, USA
    J Anim Sci 88:626-37. 2010
    ..from the sows were analyzed as a 2 x 3 x 4 factorial arrangement of treatments in a completely randomized design (CRD) with 3 replicates per treatment...
  33. ncbi CORD9 a new locus for arCRD: mapping to 8p11, estimation of frequency, evaluation of a candidate gene
    M Danciger
    Jules Stein Eye Institute, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 42:2458-65. 2001
    ....
  34. ncbi Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: results of a multicent
    S Desplat-Jego
    Laboratoire d Immunologie, CHU de la Conception, 147, Bd Baille, Marseille 13005, France
    World J Gastroenterol 13:2312-8. 2007
    ..NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn's disease (CrD) and ulcerative colitis (UC)...
  35. ncbi Evaluating the efficacy of serum haptoglobin concentration as an indicator of respiratory-tract disease in dairy calves
    C Svensson
    Department of Animal Environment and Health, Swedish University of Agricultural Sciences, P O Box 234, SE 532 23 Skara, Sweden
    Vet J 174:288-94. 2007
    ..once at 24-56 days of age to evaluate the potential of S-Hp as an indicator of clinical respiratory-tract disease (CRD)...
  36. ncbi Simultaneous measurement of optical scattering and extinction on dispersed aerosol samples
    Kathy D Dial
    Department of Chemistry and Biochemistry, MS1061, Texas Tech University, Lubbock, Texas 79409, USA
    Anal Chem 82:7885-96. 2010
    ..Extinction is measured with the well-established cavity ring-down (CRD) technique, and the scattering coefficient is determined through collection of light scattered from the CRD beam...
  37. ncbi Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency
    Nicole Draper
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Nat Genet 34:434-9. 2003
    In cortisone reductase deficiency (CRD), activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS; refs. 1,2)...
  38. ncbi [The role of norepinephrine in down-regulation of visceral sensitivity in rats deprived of rapid eye movement sleep]
    Tong Ling
    Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhonghua Nei Ke Za Zhi 47:133-6. 2008
    ..To investigate the role of norepinephrine in the down-regulated visceral sensitivity of rats deprived of rapid eye movement (REM) sleep...
  39. ncbi Autosomal recessive retinitis pigmentosa and cone-rod dystrophy caused by splice site mutations in the Stargardt's disease gene ABCR
    F P Cremers
    Department of Human Genetics, University Hospital Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Hum Mol Genet 7:355-62. 1998
    ..in a consanguineous family with individuals showing either retinitis pigmentosa (RP) or cone-rod dystrophy (CRD)...
  40. ncbi Molecular cloning of rat sperm galactosyl receptor, a C-type lectin with in vitro egg binding activity
    E Rivkin
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, New York
    Mol Reprod Dev 56:401-11. 2000
    ..Binding is mediated by a Ca(2+)-dependent carbohydrate-recognition domain (CRD) identical to that of the minor variant of rat hepatic lectin receptor 2/3 (RHL-2/3)...
  41. ncbi New laboratory methods to study tooth surface coverage and interproximal plaque control by dentifrice products
    Tao Xu
    Colgate Palmolive Technology Center, Piscataway, NJ, USA
    J Clin Dent 15:123-7. 2004
    ..The application of the model should offer visual evaluation of dentifrice coverage of the tooth surface, and measure dental plaque control at posterior interdental spaces with a dentifrice...
  42. doi A novel C-type lectin from bay scallop Argopecten irradians (AiCTL-7) agglutinating fungi with mannose specificity
    Pengfei Kong
    Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
    Fish Shellfish Immunol 30:836-44. 2011
    ..open reading frame which encoded a signal peptide of 15 residues and a conserved carbohydrate-recognition domain (CRD) of 174 residues with the EPD and WSD motifs instead of the invariant EPN and WND motifs for determining the ..
  43. doi Protective role of mouse MBL-C on intestinal mucosa during Shigella flexneri invasion
    Da Ming Zuo
    Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, People s Republic of China
    Int Immunol 21:1125-34. 2009
    ..The carbohydrate recognition domain (CRD) genes of mouse MBL-C (mMBL-C) were cloned and expressed in Escherichia coli...
  44. ncbi Selective binding of the scavenger receptor C-type lectin to Lewisx trisaccharide and related glycan ligands
    Peter J Coombs
    Glycobiology Institute, Department of Biochemistry, University of Oxford, UK
    J Biol Chem 280:22993-9. 2005
    ..A scavenger receptors for modified low density lipoproteins but contains a C-type carbohydrate-recognition domain (CRD)...
  45. doi Chylomicron retention disease: a long term study of two cohorts
    Noel Peretti
    Department of Nutrition, CHU Sainte Justine, Universite de Montreal, GI Nutrition Unit, 3175 Ste Catherine Road, Montreal, Que, Canada
    Mol Genet Metab 97:136-42. 2009
    ..secretion, mutations of the Sar1B gene coding for Sar1 GTPase are associated with chylomicron retention disease (CRD)...
  46. pmc Recombinant chimeric lectins consisting of mannose-binding lectin and L-ficolin are potent inhibitors of influenza A virus compared with mannose-binding lectin
    Wei Chuan Chang
    Program of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Biochem Pharmacol 81:388-95. 2011
    MBL structurally contains a type II-like collagenous domain and a carbohydrate recognition domain (CRD)...
  47. pmc Regulation of photoreceptor gene expression by Crx-associated transcription factor network
    Anne K Hennig
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain Res 1192:114-33. 2008
    ..This regulation is mediated by a network of photoreceptor transcription factors centered on Crx, an Otx-like homeodomain transcription factor...
  48. doi Molecular cloning of a C-type lectin with two CRD domains from the banana shrimp Fenneropenaeus merguiensis: early gene up-regulation after Vibrio harveyi infection
    Onnicha Rattanaporn
    Department of Biochemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkla, Thailand
    J Invertebr Pathol 106:196-204. 2011
    ..The first CRD comprises a QPD motif with specificity for binding galactose and a single Ca(2+) binding site, while the second CRD ..
  49. ncbi Psychological stress and the severity of post-inflammatory visceral hyperalgesia
    Tobias Liebregts
    Royal Adelaide Hospital, Department of Gastroenterology, Hepatology and General Medicine, University of Adelaide, North Terrace, Adelaide, SA 5000, Australia
    Eur J Pain 11:216-22. 2007
    ..Stress and inflammation contribute to this altered visceral sensory function. We aimed to elucidate the role of repetitive stress and acute mucosal inflammation, alone and in combination, on sensory function...
  50. doi Overcoming macrocyclic lactone resistance in Haemonchus contortus with pulse dosing of levamisole
    Kerri L Tyrrell
    CSIRO, Livestock Industries, Queensland Bioscience Precinct, Queensland, Australia
    Vet Parasitol 168:278-83. 2010
    The in vivo effect of dosing levamisole as a pulse release within an ivermectin (IVM) controlled-release device (CRD) was simulated by periodic dosing of levamisole to Haemonchus contortus-infected sheep already treated with an IVM CRD...
  51. pmc FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo
    Raghuveer S Mali
    Eye Research Institute, Oakland University, Rochester, MI, USA
    BMC Mol Biol 9:87. 2008
    ..FIZ1 in the retina increases during photoreceptor terminal maturation, when two key transcription factors NRL and CRX (Cone-Rod Homeobox) become detectable on the promoters of photoreceptor-specific genes (i.e. Rhodopsin, Pde6b)...
  52. doi First molluscan TNFR homologue in Zhikong scallop: molecular characterization and expression analysis
    Ling Li
    The Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Rd, Qingdao 266071, China
    Fish Shellfish Immunol 27:625-32. 2009
    ..necrosis factor receptors (TNFRs) are a superfamily of proteins characterized by the unique cysteine-rich domain (CRD) and their important roles in diverse physiological and pathological events such as inflammation, apoptosis, ..
  53. ncbi FIZ1 is expressed during photoreceptor maturation, and synergizes with NRL and CRX at rod-specific promoters in vitro
    Raghuveer S Mali
    Eye Research Institute, Oakland University, Rochester, MI 48309, USA
    Exp Eye Res 84:349-60. 2007
    ..Functional implications of FIZ1/NRL interaction, on NRL- and CRX-mediated activation of the Rhodopsin (Rho) and cGMP-phosphodiesterase beta-subunit gene (PDE6B) promoters, were ..
  54. pmc Inhibition of HIV-1 transmission in trans from dendritic cells to CD4+ T lymphocytes by natural antibodies to the CRD domain of DC-SIGN purified from breast milk and intravenous immunoglobulins
    Mary Requena
    Unité INSERM U743, Equipe Immunité et Biothérapie Muqueuse, Centre de Recherches Biomedicales des Cordeliers, Paris, France
    Immunology 123:508-18. 2008
    ..functional natural immunoglobulin A (IgA) and IgG antibodies directed against the carbohydrate recognition domain (CRD) domain of the dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) molecule, ..
  55. ncbi Naturally-occurring chronic renal disease in Australian cats: a prospective study of 184 cases
    J D White
    Faculty of Veterinary Science, The University of Sydney, Australia
    Aust Vet J 84:188-94. 2006
    To describe cases of naturally occurring feline chronic renal disease (CRD) in a defined population of Sydney.
  56. doi The effectiveness and active ingredients of mutual support groups for family caregivers of people with psychotic disorders: a literature review
    Wai Tong Chien
    The School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnics, Hung Hom, Kowloon, Hong Kong SAR, China
    Int J Nurs Stud 46:1604-23. 2009
    ..To explore the literature through a systematic search to assess the effectiveness of mutual support groups for family caregivers of people with schizophrenia and other psychotic disorders...
  57. ncbi Role of corticotropin-releasing factor pathways in stress-related alterations of colonic motor function and viscerosensibility in female rodents
    YVETTE TACHE
    Center for Neurovisceral Sciences and Women s Health, and CURE Digestive Diseases Research Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Gend Med 2:146-54. 2005
    ..In rodents, colorectal distention (CRD) induces abdominal contractions, and this visceromotor response is used to assess visceral pain...
  58. ncbi Conserved transcriptional activators of the Xenopus rhodopsin gene
    S Leigh Whitaker
    Departments of Biochemistry and Molecular Biology and Ophthalmology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 279:49010-8. 2004
    ..identify and characterize two transcriptional activators of the Xenopus rhodopsin gene: homologs of the mammalian Crx and Nrl transcription factors, XOtx5 and XL-Nrl (originally named XL-maf), respectively...
  59. doi The impact of a single 24 h working day on cognitive and psychomotor performance in staff anaesthesiologists
    Nenad Karanovic
    Department of Anesthesiology and Intensive Care, University Hospital Split, Croatia
    Eur J Anaesthesiol 26:825-32. 2009
    ..The aim of this study was to explore the impact of a single in-hospital 24 h shift on the cognitive and psychomotor performance of anaesthesiologists in a surgical emergency department...
  60. doi Corticotropin-releasing hormone receptor 1 antagonist blocks colonic hypersensitivity induced by a combination of inflammation and repetitive colorectal distension
    K Saito-Nakaya
    Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Neurogastroenterol Motil 20:1147-56. 2008
    ..We tested the hypothesis that a combination of previous inflammation and repetitive colorectal distention (CRD) makes the colon hypersensitive and that treatment with a corticotropin-releasing hormone receptor 1 (CRH-R1) ..
  61. ncbi A three base pair deletion encoding the amino acid (lysine-270) in the alpha-cone transducin gene
    Ana Luisa Pina
    McGill Ocular Genetics Laboratory, Montreal Children s Hospital Research Institute, McGill University, Montreal, PQ, Canada
    Mol Vis 10:265-71. 2004
    ..In this study we tested the hypothesis that mutations in GNAT2 cause cone-rod degeneration (CRD).
  62. doi The GABA(B) receptor agonist, baclofen, and the positive allosteric modulator, CGP7930, inhibit visceral pain-related responses to colorectal distension in rats
    Mikael Brusberg
    AstraZeneca R and D, Molndal, Sweden
    Neuropharmacology 56:362-7. 2009
    ..Female Sprague-Dawley rats were subjected to repeated, noxious colorectal distension (CRD) (12 distensions at 80 mmHg, for 30 s with 5 min intervals)...
  63. doi Component-resolved diagnosis from latex allergy by microarray
    D G Ebo
    Department of Immunology Allergology Rheumatology, Faculty of Medicine, University of Antwerp, Antwerp, Belgium
    Clin Exp Allergy 40:348-58. 2010
    ..A positive specific IgE (sIgE) result for latex does not always mirror the clinical situation and is frequently found in individuals without overt latex allergy...
  64. pmc Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin with digenic disease
    Yong Qing Gao
    Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Vis 13:287-92. 2007
    ..other transcription factors such as SP1, neural retina leucine zipper protein (NRL), and cone-rod homeobox gene (CRX)...
  65. ncbi Reanalysis of systematic reviews: the case of invasive strategies for acute coronary syndromes
    Pekka Kuukasjärvi
    Finnish Office for Health Technology Assessment Finohta, Helsinki
    Int J Technol Assess Health Care 22:484-96. 2006
    ....
  66. ncbi Evaluation of pseudo-affective responses to noxious colorectal distension in rats by manometric recordings
    Anna Tammpere
    AstraZeneca R and D, Integrative Pharmacology, GI Biology, S 431 83 Molndal, Sweden
    Pain 116:220-6. 2005
    ..are generally used to quantify the pseudo-affective visceromotor response induced by colorectal distension (CRD) in rodents...
  67. pmc Enhanced responses of the anterior cingulate cortex neurones to colonic distension in viscerally hypersensitive rats
    Jun Gao
    Gastroenterology Research Unit, Department of Internal Medicine, University of Michigan, 6510 Medical Sciences Research Building I, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0682, USA
    J Physiol 570:169-83. 2006
    ..Single ACC neuronal activities in response to colorectal distension (CRD) were recorded in control, sham-treated rats and viscerally hypersensitive (EA) rats (induced by chicken egg ..
  68. doi Galectin LEC-1 plays a defensive role against damage due to oxidative stress in Caenorhabditis elegans
    Tomoharu Takeuchi
    Laboratory of Molecular Immunology, Faculty of Pharmaceutical Sciences, Josai University, 1 1 Keyakidai, Sakado, Saitama 350 0295 and Laboratory of Biological Chemistry, Faculty of Pharma Sciences, Teikyo University, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8605, Japan
    J Biochem 154:455-64. 2013
    LEC-1 is a major galectin in Caenorhabditis elegans and contains two carbohydrate recognition domains (CRDs), N-CRD and C-CRD. To determine the role of LEC-1, we examined the phenotypes of a mutant C. elegans strain lacking lec-1...
  69. ncbi Estrogen modulates the visceromotor reflex and responses of spinal dorsal horn neurons to colorectal stimulation in the rat
    Yaping Ji
    Department of Oral and Craniofacial Biological Sciences, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 23:3908-15. 2003
    ..We characterized the effects of estrogen on two responses to colorectal distention (CRD) in the rat: the visceromotor reflex (vmr) and L6-S1 dorsal horn neuron activity (ABRUPT and SUSTAINED neurons)...
  70. pmc Acute nociceptive somatic stimulus sensitizes neurones in the spinal cord to colonic distension in the rat
    Shachar Peles
    Division of Gastroenterology and Hepatology, MaccFund Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Physiol 560:291-302. 2004
    ..of acid injections, into the ipsilateral somatic receptive field of neurones responsive to colorectal distension (CRD), and the potential role of ionotropic glutamate receptors on sensitization...
  71. ncbi Differential processing of noxious colonic input by thoracolumbar and lumbosacral dorsal horn neurons in the rat
    Gexin Wang
    Department of Biomedical Sciences, Dental School, University of Maryland, Baltimore, 21201, USA
    J Neurophysiol 94:3788-94. 2005
    ..In this study, the effects of colorectal distention (CRD) on TL and LS dorsal horn neuronal activity were recorded in Nembutal-anesthetized male rats both with and without ..
  72. pmc Sequence-specific recognition of colicin E5, a tRNA-targeting ribonuclease
    Tetsuhiro Ogawa
    Department of Biotechnology, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Nucleic Acids Res 34:6065-73. 2006
    ..Since this activity is confined to its 115 amino acid long C-terminal domain (CRD), the recognition mechanism of E5-CRD is of great interest...
  73. ncbi Assessment of visceral pain-related pseudo-affective responses to colorectal distension in mice by intracolonic manometric recordings
    Susanne Arvidsson
    Integrative Pharmacology Gastrointestinal Biology, AstraZeneca R and D Molndal, Molndal, Sweden
    J Pain 7:108-18. 2006
    ..a new manometric method has been proposed to quantify visceromotor responses (VMR) to colorectal distension (CRD) in rats. This method is based on monitoring pressure changes within the distending balloon during CRD...
  74. ncbi The carbohydrate-recognition domain of E-selectin is sufficient for ligand binding under both static and flow conditions
    F Kolbinger
    Ciba Central Research, Basel, Switzerland
    Biochemistry 35:6385-92. 1996
    ..adhesion molecules with a well-defined domain structure comprised of a lectin or carbohydrate-recognition domain (CRD), an epidermal growth factor (EGF)-like motif, and a variable number of consensus repeats (CRs)...
  75. doi CRX/OTX3: a useful marker in the differential diagnosis of tumors of the pineal region and indicator of photoreceptor differentiation in medulloblastomas and atypical teratoid rhabdoid tumors
    Gerrit H Gielen
    Institute of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Appl Immunohistochem Mol Morphol 21:248-53. 2013
    CRX (OTX3) is a transcription factor of the OTX homeobox family, whose expression and function is essential for the development and differentiation of retinal and pineal cells...
  76. pmc Sex differences in spinal processing of transient and inflammatory colorectal stimuli in the rat
    Yaping Ji
    Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA
    Pain 153:1965-73. 2012
    ..The visceromotor response to colorectal distention (CRD) was more robust in normal female rats and after intracolonic mustard oil compared with that in male rats...
  77. ncbi Expression and characterization of a variant of TACI (CRD2-shortTACIFc) in Pichia pastoris
    Rui Wang
    Department of Biochemistry and Molecular Biology, Key Laboratory of Molecular Medicine, The Ministry of Education, Shanghai Medical College, Shanghai, People s Republiof China
    Protein Pept Lett 19:315-25. 2012
    ..The extracellular domain of a typical TNFR contains multiple copies of CRD, which bind in the monomermonomer interfaces of a trimeric ligand...
  78. pmc Butyrate attenuates lipopolysaccharide-induced inflammation in intestinal cells and Crohn's mucosa through modulation of antioxidant defense machinery
    Ilaria Russo
    Department of Clinical and Experimental Medicine, Federico II University of Naples, Napoli, Italy
    PLoS ONE 7:e32841. 2012
    ..stress plays an important role in the pathogenesis of inflammatory bowel disease (IBD), including Crohn's disease (CrD)...
  79. doi CB1 receptors mediate the analgesic effects of cannabinoids on colorectal distension-induced visceral pain in rodents
    Mikael Brusberg
    Biosciences, AstraZeneca R and D Molndal, Mölndal SE 431 83, Sweden
    J Neurosci 29:1554-64. 2009
    ..cannabinoid system on basal pain responses and acute mechanical hyperalgesia during colorectal distension (CRD) in rodents...
  80. doi Age-related sensitization profiles for hazelnut (Corylus avellana) in a birch-endemic region
    K J De Knop
    Faculty of Medicine, Department of Immunology Allergology Rheumatology, University of Antwerp, Universiteitsplein 1, Antwerp, Belgium
    Pediatr Allergy Immunol 22:e139-49. 2011
    ..Symptoms of hazelnut allergy seem related to geographic and possibly age variations in allergen recognition...
  81. pmc Subdiaphragmatic vagal afferent nerves modulate visceral pain
    S L Chen
    Gastroenterology Research Unit, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0682, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1441-9. 2008
    ..Visceromotor responses (VMR) to graded colorectal distension (CRD) were recorded from the abdominal muscles in conscious rats...
  82. pmc CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors
    Joseph C Corbo
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110 1024, USA
    Genome Res 20:1512-25. 2010
    ..Cone-rod homeobox (CRX) is a key transcription factor in photoreceptor differentiation and survival, but its in vivo targets are largely ..
  83. doi Functional and structural changes in the retina of wire-haired dachshunds with early-onset cone-rod dystrophy
    Ernst O Ropstad
    Department of Companion Animal Clinical Sciences, Division of Genetics, Norwegian University School of Veterinary Science, Oslo, Norway
    Invest Ophthalmol Vis Sci 49:1106-15. 2008
    To describe and classify the morphologic changes in a naturally occurring dog model of early-onset cone-rod dystrophy (CRD) and to correlate these with earlier described clinical characteristics of the disease in dogs.
  84. doi Lack of colonic-inflammation-induced acute visceral hypersensitivity to colorectal distension in Na(v)1.9 knockout mice
    V Martinez
    Integrative Pharmacology, Gastrointestinal Biology, AstraZeneca R and D Molndal, Molndal, Sweden
    Eur J Pain 12:934-44. 2008
    ..9 knockout (KO) mice. Colorectal distension (CRD)-induced visceral pain was assessed in conscious wild-type and Na(v)1.9 KO mice (C57Bl/6 background)...
  85. pmc Molecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo receptor formation and ER-to-Golgi transport of FV/FVIII
    Chunlei Zheng
    Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
    Blood 116:5698-706. 2010
    ..LMAN1 (ERGIC-53) is a hexameric transmembrane protein with a carbohydrate recognition domain (CRD) on the ER luminal side...
  86. doi Lactobacillus farciminis treatment attenuates stress-induced overexpression of Fos protein in spinal and supraspinal sites after colorectal distension in rats
    A Ait-Belgnaoui
    Neuro Gastroenterology and Nutrition Unit, UMR INRA EI Purpan, Toulouse, France
    Neurogastroenterol Motil 21:567-73, e18-9. 2009
    ..have previously shown that Lactobacillus farciminis treatment abolished the hyperalgesia to colorectal distension (CRD) induced by acute stress...
  87. ncbi Dietary cholesterol from eggs increases plasma HDL cholesterol in overweight men consuming a carbohydrate-restricted diet
    Gisella Mutungi
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 138:272-6. 2008
    Carbohydrate-restricted diets (CRD) significantly decrease body weight and independently improve plasma triglycerides (TG) and HDL cholesterol (HDL-C)...
  88. ncbi The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site
    Lorenz Chatwell
    Lehrstuhl fur Biologische Chemie, Technische Universitat Munchen, 85350 Freising Weihenstephan, Germany
    Mol Immunol 45:1981-94. 2008
    ..region with several heptad repeats and an exposed carboxy-terminal calcium-type carbohydrate-recognition domain (CRD). The CRD of human Langerin, which was expressed as a soluble protein in the periplasm of E...
  89. doi Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activated feed-back loop in visceral inflammatory pain
    A Annahazi
    Toxalim UMR 1331 INRA INP UPS Neuro Gastroenterology and Nutrition Unit, Toulouse, France
    Neurogastroenterol Motil 24:76-85, e13. 2012
    ..receptor-4 (PAR-4) from the colonic lumen has an antinociceptive effect to colorectal distension (CRD) in mice in basal conditions...
  90. ncbi Risk factors for development of cardiovascular complications in patients with chronic renal disease and diabetic nephropathy
    Amra Mataradzija
    Clinic for Nephrology, University of Sarajevo Clinics Centre, Bolnicka 25, Sarajevo, Bosnia and Herzegovina
    Bosn J Basic Med Sci 10:S44-50. 2010
    ..The aim of our paper is to evaluate the risk factors of cardiovascular complications in patients with various stages of chronic renal disease (CRD), with or without diabetes mellitus (DM).
  91. doi RegIV potentiates colorectal carcinoma cell migration and invasion via its CRD domain
    Ying Guo
    Department of Pathology, Southeastern University, Nanjing, China
    Cancer Genet Cytogenet 199:38-44. 2010
    ..In this study, we investigated the role of RegIV and its CRD domain in the invasion and migration of human colorectal carcinoma LoVo cells. Recombinant plasmids, pcDNA3...
  92. doi Under-report and underdiagnosis of chronic respiratory diseases in an African country
    P Martins
    Immunoallergy Department, Dona Estefania Hospital, Rua Jacinta Marto, Lisbon, Portugal
    Allergy 64:1061-7. 2009
    Chronic respiratory diseases (CRD) are greatly underestimated...
  93. doi Carotid artery stenting: Impact of practitioner specialty and volume on outcomes and resource utilization
    Todd R Vogel
    Division of Vascular Surgery, The Surgical Outcomes Research Group, University of Medicine and Dentistry, New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08903 0019, USA
    J Vasc Surg 49:1166-71. 2009
    ..We analyzed differences in outcomes after CAS was performed by radiologists (RAD), cardiologists (CRD), and vascular surgeons (VAS).
  94. ncbi [Relationship between NR1 subunit of N-methyl-D-aspartate receptor and visceral hypersensitivity caused by acute restraint stress: experiment with rats]
    Lei Shen
    Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhonghua Yi Xue Za Zhi 89:939-42. 2009
    ..To investigate the response of NR1 subunit of N-methyl-D-aspartate (NMDA) receptor to restraint stress in intestinal tract...
  95. pmc Differential CRX and OTX2 expression in human retina and retinoblastoma
    Darryl D Glubrecht
    Department of Oncology, University of Alberta, Edmonton, Alberta, Canada
    J Neurochem 111:250-63. 2009
    ..of the orthodenticle family implicated in photoreceptor and bipolar cell differentiation, cone-rod homeobox, CRX, and orthodenticle homeobox 2, OTX2, in normal human retina, retinoblastoma cell lines and retinoblastoma tumors...
  96. doi Sensitization profiles in birch pollen-allergic patients with and without oral allergy syndrome to apple: lessons from multiplexed component-resolved allergy diagnosis
    D G Ebo
    Departments of Immunology, Allergology, Rheumatology, Faculty of Medicine, University of Antwerp, Antwerpen, Belgium
    Clin Exp Allergy 40:339-47. 2010
    Component-resolved diagnosis (CRD) using microarray technology has recently been introduced into the field of clinical allergology.
  97. doi The clinical effectiveness and cost-effectiveness of bariatric (weight loss) surgery for obesity: a systematic review and economic evaluation
    J Picot
    Southampton Health Technology Assessments Centre, University of Southampton, UK
    Health Technol Assess 13:1-190, 215-357, iii-iv. 2009
    ..To assess the clinical effectiveness and cost-effectiveness of bariatric surgery for obesity...
  98. pmc Increased cardiovascular risk in rats with primary renal dysfunction; mediating role for vascular endothelial function
    M K Szymański
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Basic Res Cardiol 107:242. 2012
    ..to experimental myocardial infarction to induce cardiac dysfunction (CD) and combined cardiorenal dysfunction (CRD), respectively (N = 5-10). Twelve weeks later, cardiac- and renal parameters were evaluated...
  99. doi [Study of oxidative stress in advanced kidney disease]
    M J Puchades Montesa
    Servicio de Nefrologia, Hospital Clinico Universitario de Valencia, Valencia, Spain
    Nefrologia 29:464-73. 2009
    Introduction Patients with Chronic renal Disease (CRD) often have cardiovascular disease that is the main cause of morbidity and mortality. Oxidative stress and a subclinical inflammation are crucial factors in its development...
  100. doi Anatomical changes in the primary visual cortex of the congenitally blind Crx-/- mouse
    Y Goldshmit
    Australian Regenerative Medicine Institute, Monash University, Vic, 3800 Australia
    Neuroscience 166:886-98. 2010
    Mutations in the human cone-rod homeobox (Crx) gene are associated with retinal dystrophies such as Leber Congenital Amaurosis (LCA), characterized by complete or near complete absence of vision from birth...
  101. doi Inducible galectins are expressed in the inflamed pharynx of the ascidian Ciona intestinalis
    Aiti Vizzini
    Department of Environmental Biology and Biodiversity, Laboratory of Marine Immunobiology, University of Palermo, Via Archirafi 18, 90123 Palermo, Italy
    Fish Shellfish Immunol 32:101-9. 2012
    ..In the present paper, to contribute in disclosing Bi-CRD galectin evolution a novel attempt was carried out on CiLgals-a and -b CRDs phylogenetic analysis, and their ..

Research Grants76

  1. PATHOGENESIS OF ACANTHAMOEBA KERATITIS
    Noorjahan Panjwani; Fiscal Year: 2010
    ..hypothesize that the presence of antibodies in tear fluid specifically against the carbohydrate recognition domain (CRD) of MBP should be protective...
  2. ENHANCING COLLECTIN MEDIATED HOST DEFENSE
    Kevan Hartshorn; Fiscal Year: 2001
    ..which incorporates the N-terminus and collagen domain of SP-D fused with the carbohydrate recognition domain (CRD) of conglutinin...
  3. ADHERENCE BLOCKING VACCINE FOR AMEBIASIS
    William Petri; Fiscal Year: 2003
    ..In Project 2, recombinant CRD containing peptides will be expressed in edible plants...
  4. Field Studies of Human Immunity to Amebiasis in Bangladesh
    William Petri; Fiscal Year: 2007
    ..histolytica Gal/GalNAc lectin carbohydrate recognition domain (CRD) have an 86% reduction in new infections at one year of follow-up...
  5. PATHOGENESIS OF ACANTHAMOEBA KERATITIS
    Noorjahan Panjwani; Fiscal Year: 2011
    ..hypothesize that the presence of antibodies in tear fluid specifically against the carbohydrate recognition domain (CRD) of MBP should be protective...
  6. Mechanisms of social-stress enhanced allergic airway response in a mouse model
    Angela Haczku; Fiscal Year: 2010
    ..By studying the effects of a recombinant mutant SP-D containing the carbohydrate recognition (CRD), but not the collagen domain, and blocking antibodies against the negative Signal-Regulatory Protein (SIRP) on ..
  7. SCA7 RETINAL DEGENERATION: MOLECULAR BASIS & THERAPY
    Albert La Spada; Fiscal Year: 2006
    ..interfering with the transactivation function of a nuclear transcription factor, the cone-rod homeodomain protein (CRX)...
  8. NEUROCHEMICAL MECHANISMS OF VISCERAL PAIN
    Richard J Traub; Fiscal Year: 2010
    ..ER1 and ER2) in the spinal cord differentially modulate the visceromotor response to colorectal distention (CRD)...
  9. NEUROCHEMICAL MECHANISMS OF VISCERAL PAIN
    RICHARD TRAUB; Fiscal Year: 2009
    ..ER1 and ER2) in the spinal cord differentially modulate the visceromotor response to colorectal distention (CRD)...
  10. Metabolism of Endothelial Dysfunction in Renal Disease
    Leticia Castillo; Fiscal Year: 2005
    ..The aims are: (1) to assess NO bioavailability in CRD and ESRD patients and in healthy controls in relation to: (l...
  11. Metabolism of Endothelial Dysfunction in Renal Disease
    Leticia Castillo; Fiscal Year: 2006
    ..The aims are: (1) to assess NO bioavailability in CRD and ESRD patients and in healthy controls in relation to: (l...
  12. Smoked Marijuana Discrimination and Marijuana Choice in Humans: A Laboratory Mode
    Leslie H Lundahl; Fiscal Year: 2010
    ..Drug choice procedures offer another valid approach for testing CRD medications...
  13. Smoked Marijuana Discrimination and Marijuana Choice in Humans: A Laboratory Mode
    LESLIE LUNDAHL; Fiscal Year: 2009
    ..Drug choice procedures offer another valid approach for testing CRD medications...
  14. Enhancing Collectin-Mediated Defense Against Influenza
    Kevan Hartshorn; Fiscal Year: 2005
    ..Since SP-D binds to IAV, phagocytes, phospholipids and gp340, through its carbohydrate recognition domain (CRD), the contribution of specific parts of the CRD to these functional activities will be intensively examined...
  15. Role of an RNA-Binding Protein in Mammary Carcinogenesis
    Jeffrey Ross; Fiscal Year: 2009
    ..We call it the c-myc Coding Region instability Determinant-binding Protein or CRD-BP. because it binds to an instability determinant in the c-myc mRNA coding region...
  16. Role of an RNA-Binding Protein in Mammary Carcinogenesis
    Jeffrey Ross; Fiscal Year: 2007
    ..We call it the c-myc Coding Region instability Determinant-binding Protein or CRD-BP. because it binds to an instability determinant in the c-myc mRNA coding region...
  17. Agonist & Antagonist Activity and Binding on the TMD of hT1R3
    Marianna Max; Fiscal Year: 2010
    ..least 4 binding regions of the sweet receptor: the venus fly trap module (VFTM) of hT1R2, the cysteine-rich domain (CRD) of hT1R3 and the transmembrane domain (TMD) of hT1R3...
  18. Axonal regulation of Schwann Cells--Novel Roles of NRG1
    James Salzer; Fiscal Year: 2005
    ..with neurons isolated from mice with either a conditional, neuron-specific knockout of NRG-1 or a knockout of the CRD-NRG-l isoform...
  19. CELL SURFACE CARBOHYDRATE RECOGNITION BY C-TYPE LECTINS
    WILLIAM WEIS; Fiscal Year: 2003
    ..Structures of a single carbohydrate-recognition domain (CRD) will be determined in complex with ligands to probe the unique features of ligand recognition by this receptor...
  20. NICHD Maternal Fetal Medicine Units Network
    George Saade; Fiscal Year: 2007
    ..The Department's team of dedicated research nurses and coordinators (Chairman's Research Division [CRD]) and the Tissue BioBank, both under the direction of the PI, have broadened efficiency in clinical investigations...
  21. REGULATION OF FETAL HEPATIC GROWTH
    PHILIP GRUPPUSO; Fiscal Year: 2005
    ..expression of the critical proto-oncogene, c-myc, may be regulated by a coding region determinant binding protein (CRD-BP) that stabilizes c-mycmRNA...