CRX

Summary

Gene Symbol: CRX
Description: cone-rod homeobox
Alias: CORD2, CRD, LCA7, OTX3, cone-rod homeobox protein, orthodenticle homeobox 3
Species: human
Products:     CRX

Top Publications

  1. Swain P, Chen S, Wang Q, Affatigato L, Coats C, Brady K, et al. Mutations in the cone-rod homeobox gene are associated with the cone-rod dystrophy photoreceptor degeneration. Neuron. 1997;19:1329-36 pubmed
    b>Crx is a novel paired-like homeodomain protein that is expressed predominantly in retinal photoreceptors and pinealocytes. Its gene has been mapped to chromosome 19q13...
  2. Freund C, Gregory Evans C, Furukawa T, Papaioannou M, Looser J, Ploder L, et al. Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor. Cell. 1997;91:543-53 pubmed
    ..homeodomain transcription factor gene (CRX) cause an autosomal dominant form of cone-rod dystrophy (adCRD) at the CORD2 locus on chromosome 19q13...
  3. Swaroop A, Wang Q, Wu W, Cook J, Coats C, Xu S, et al. Leber congenital amaurosis caused by a homozygous mutation (R90W) in the homeodomain of the retinal transcription factor CRX: direct evidence for the involvement of CRX in the development of photoreceptor function. Hum Mol Genet. 1999;8:299-305 pubmed
    The CRX (cone-rod homeobox) gene is specifically expressed in developing and mature photoreceptors and encodes an otd/Otx-like paired homeodomain protein...
  4. Peng G, Ahmad O, Ahmad F, Liu J, Chen S. The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes. Hum Mol Genet. 2005;14:747-64 pubmed
    ..Using yeast two-hybrid screens with Nr2e3 as bait, the cone-rod homeobox protein Crx was identified as an interacting partner of Nr2e3...
  5. Freund C, Wang Q, Chen S, Muskat B, Wiles C, Sheffield V, et al. De novo mutations in the CRX homeobox gene associated with Leber congenital amaurosis. Nat Genet. 1998;18:311-2 pubmed
  6. Bibb L, Holt J, Tarttelin E, Hodges M, Gregory Evans K, Rutherford A, et al. Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development. Hum Mol Genet. 2001;10:1571-9 pubmed
    Cone--rod homeobox (CRX), a paired-like homeobox transcription factor, plays a major role in photoreceptor development and maintenance of the retina...
  7. Wang X, Xu S, Rivolta C, Li L, Peng G, Swain P, et al. Barrier to autointegration factor interacts with the cone-rod homeobox and represses its transactivation function. J Biol Chem. 2002;277:43288-300 pubmed
    b>Crx (cone-rod homeobox) is a homeodomain transcription factor implicated in regulating the expression of photoreceptor and pineal genes...
  8. Chen S, Wang Q, Nie Z, Sun H, Lennon G, Copeland N, et al. Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron. 1997;19:1017-30 pubmed
    ..a bait containing the Ret 4 site from the bovine rhodopsin promoter, we have cloned a new member of the family, Crx (Cone rod homeobox)...
  9. Wei X, Wang L, Sun W, Zhang M, Ma H, Zhang Y, et al. C-type lectin B (SpCTL-B) regulates the expression of antimicrobial peptides and promotes phagocytosis in mud crab Scylla paramamosain. Dev Comp Immunol. 2018;84:213-229 pubmed publisher
    ..The predicted SpCTL-B protein contains a single carbohydrate-recognition domain (CRD). SpCTL-B transcripts were distributed in all examined tissues with the highest levels in hepatopancreas...

More Information

Publications131 found, 100 shown here

  1. Zhang X, Shi Y, Chen J. Molecular characterization of a transmembrane C-type lectin receptor gene from ayu (Plecoglossus altivelis) and its effect on the recognition of different bacteria by monocytes/macrophages. Mol Immunol. 2015;66:439-50 pubmed publisher
    ..Predicted PaCTLRC is a single transmembrane receptor with a typical carbohydrate recognition domain (CRD) at its C-terminus...
  2. Lv C, Zhang D, Wang Z. A novel C-type lectin, Nattectin-like protein, with a wide range of bacterial agglutination activity in large yellow croaker Larimichthys crocea. Fish Shellfish Immunol. 2016;50:231-41 pubmed publisher
    ..LcNTC contained a single CRD with four conserved disulfide-bonded cysteine residues (Cys(57)-Cys(148), Cys(126)-Cys(140)) and EPN/AND motifs ..
  3. Jia W, Shang N, Guo Q. Molecular cloning of rhamnose-binding lectin gene and its promoter region from snakehead Channa argus. Fish Physiol Biochem. 2010;36:451-459 pubmed publisher
    ..The molecular structure of SHL is composed of two tandem repeat carbohydrate recognition domains (CRD) with 35% internal identity...
  4. Huang M, Zhou T, Wu Y, Fei H, Wang G, Li Z, et al. Characterisation and functional comparison of single-CRD and multidomain containing galectins CgGal-2 and CgGal-3 from oyster Crassostrea gigas. Fish Shellfish Immunol. 2018;78:238-247 pubmed publisher
    ..In the present study, single- and four-CRD-containing galectins were identified in oyster Crassostrea gigas (designated CgGal-2 and CgGal-3)...
  5. Xing Q, Yu Q, Dou H, Wang J, Li R, Ning X, et al. Genome-wide identification, characterization and expression analyses of two TNFRs in Yesso scallop (Patinopecten yessoensis) provide insight into the disparity of responses to bacterial infections and heat stress in bivalves. Fish Shellfish Immunol. 2016;52:44-56 pubmed publisher
    ..factors receptors (TNFRs) comprise a superfamily of proteins characterized by a unique cysteine-rich domain (CRD) and play important roles in diverse physiological and pathological processes in the innate immune system, ..
  6. Pagel R, Bär F, Schröder T, Sünderhauf A, Künstner A, Ibrahim S, et al. Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine. FASEB J. 2017;31:4707-4719 pubmed publisher
    Endogenous circadian clocks regulate 24-h rhythms of physiology and behavior. Circadian rhythm disruption (CRD) is suggested as a risk factor for inflammatory bowel disease. However, the underlying molecular mechanisms remain unknown...
  7. Chaney S, Mukherjee S, Giddabasappa A, Rueda E, Hamilton W, Johnson J, et al. Increased proliferation of late-born retinal progenitor cells by gestational lead exposure delays rod and bipolar cell differentiation. Mol Vis. 2016;22:1468-1489 pubmed
    ..Real-time quantitative PCR (RT-qPCR) with the rod-specific transcription factors Nrl, Nr2e3, and Crx and the rod-specific functional gene Rho, along with central retinal confocal studies with anti-..
  8. Wang L, Zhang J, Kong X, Zhao X, Pei C, Li L. A C-type lectin, Nattectin-like protein (CaNTC) in Qihe crucian carp Carassius auratus: Binding ability with LPS, PGN and various bacteria, and agglutinating activity against bacteria. Fish Shellfish Immunol. 2017;67:382-392 pubmed publisher
    ..The deduced amino acid sequence of CaNTC contained a signal peptide, a single carbohydrate recognition domain (CRD) which had four conserved disulfide-bonded cysteine residues (Cys57-Cys150, Cys126-..
  9. Mitton K, Guzman A, Deshpande M, Byrd D, DeLooff C, Mkoyan K, et al. Different effects of valproic acid on photoreceptor loss in Rd1 and Rd10 retinal degeneration mice. Mol Vis. 2014;20:1527-44 pubmed
    ..Nrl gene expression was decreased by 50%, while Crx gene expression was not affected...
  10. Wang H, Xue Z, Liu Z, Wang W, Wang F, Wang Y, et al. A novel C-type lectin from the sea cucumber Apostichopus japonicus (AjCTL-2) with preferential binding of d-galactose. Fish Shellfish Immunol. 2018;79:218-227 pubmed publisher
    ..a low density lipoprotein receptor class A (LDLa), a C1r/C1s/Uegf/bone morphogenetic protein 1 (CUB), and a CRD with two motifs Glu-Pro-Asn (EPN) and Trp-Asn-Asp (WND) in Ca2+ binding site 2...
  11. Li Z, Wang J, Gao F, Tian H, Shi X, Lian C, et al. Human Adipose-Derived Stem Cells Delay Retinal Degeneration in Royal College of Surgeons Rats Through Anti-Apoptotic and VEGF-Mediated Neuroprotective Effects. Curr Mol Med. 2016;16:553-66 pubmed
    ..Consistent with these phenotypic changes, the gene expression of rod photoreceptor markers Rhodopsin (Rho), Crx and Opsin (Opn1) in RCS rats showed obvious decreasing trends over time after PN 3 weeks, but were elevated with ..
  12. Mao Y, Li Z, Chen K, Yu H, Zhang S, Jiang M, et al. Antinociceptive Effect of Ghrelin in a Rat Model of Irritable Bowel Syndrome Involves TRPV1/Opioid Systems. Cell Physiol Biochem. 2017;43:518-530 pubmed publisher
    ..Maternal deprivation (MD) was used to provide a stress-induced model of IBS in Wistar rats. Colorectal distension (CRD) was used to detect visceral sensitivity, which was evaluated by abdominal withdrawal reflex (AWR) scores...
  13. Bellucci F, Buéno L, Bugianesi R, Crea A, D Aranno V, Meini S, et al. Gender-related differential effect of tachykinin NK2 receptor-mediated visceral hyperalgesia in guinea pig colon. Br J Pharmacol. 2016;173:1329-38 pubmed publisher
    ..Electromyographic recording of the responses to colorectal distension (CRD) was made 3 days later. Ibodutant (0.33 , 0.65, 1.9 and 6.5 mg·kg(-1) ) was given s.c...
  14. Huang L, Li Z, Tian H, Wang W, Cui D, Zhou Z, et al. Adult human periodontal ligament-derived stem cells delay retinal degeneration and maintain retinal function in RCS rats. Stem Cell Res Ther. 2017;8:290 pubmed publisher
    ..transplantation, as reflected in the preservation of outer nuclear layer thickness and gene expression of Rho, Crx, and Opsin...
  15. Wu B, Zhang C, Qin X, Shi L, Zhao M. Identification and function of penaeidin 3 and penaeidin 5 in Fenneropenaeus merguiensis. Fish Shellfish Immunol. 2019;: pubmed publisher
    ..Both FmPEN3 and FmPEN5 contain an N-terminal proline-rich domain (PRD) and a C-terminal cysteine-rich domain (CRD). The genome structure of FmPEN3 and FmPEN5 genes both consist of 2 exons and 1 intron...
  16. Rahn D, Carberry C, Sanses T, Mamik M, Ward R, Meriwether K, et al. Vaginal estrogen for genitourinary syndrome of menopause: a systematic review. Obstet Gynecol. 2014;124:1147-56 pubmed publisher
    ..PROSPERO International prospective register of systematic reviews, http://www.crd.york.ac.uk/PROSPERO/, CRD42013006656.
  17. Thulasitha W, Whang I, Umasuthan N, Kang H, Mothishri M, Lee S, et al. A galectin related protein from Oplegnathus fasciatus: Genomic, molecular, transcriptional features and biological responses against microbial pathogens. Dev Comp Immunol. 2016;56:13-24 pubmed publisher
    ..an open reading frame (ORF) of 438 bp, encoding 145 amino acids, with a single carbohydrate recognition domain (CRD)...
  18. Tachibana M, Suwanabun N, Kaneko O, Iriko H, Otsuki H, Sattabongkot J, et al. Plasmodium vivax gametocyte proteins, Pvs48/45 and Pvs47, induce transmission-reducing antibodies by DNA immunization. Vaccine. 2015;33:1901-8 pubmed publisher
    ..In one Thai isolate we found that the fourth cysteine residue in the Pvs47 cysteine-rich domain (CRD) III (amino acid position 337) is substituted to phenylalanine...
  19. Lee J, Kim N, Nam R, Sohn S, Lee S, Choi D, et al. Probiotics reduce repeated water avoidance stress-induced colonic microinflammation in Wistar rats in a sex-specific manner. PLoS ONE. 2017;12:e0188992 pubmed publisher
    ..The visceromotor response (VMR) to colorectal distension (CRD) was assessed using a barostat and noninvasive manometry before and after WAS exposure...
  20. Gil D, Wang J, Gu C, Donello J, Cabrera S, Al Chaer E. Role of sympathetic nervous system in rat model of chronic visceral pain. Neurogastroenterol Motil. 2016;28:423-31 pubmed publisher
    ..Rats were treated to a series of colorectal balloon distensions (CRD) as neonates resulting in visceral and somatic hypersensitivity and altered stool function that persists into ..
  21. Ahmadzai N, Kilty S, Wolfe D, Bonaparte J, Schramm D, Fitzpatrick E, et al. A protocol for a network meta-analysis of interventions to treat patients with sudden sensorineural hearing loss. Syst Rev. 2018;7:74 pubmed publisher
    ..PROSPERO registration number: CRD 42017073756 .
  22. Fatoye F, Gebrye T, Odeyemi I. Real-world incidence and prevalence of low back pain using routinely collected data. Rheumatol Int. 2019;: pubmed publisher
    ..PROSPERO registration number: CRD42017078598, https://www.crd.york.ac.uk/prospero/ .
  23. Appelbaum T, Becker D, Santana E, Aguirre G. Molecular studies of phenotype variation in canine RPGR-XLPRA1. Mol Vis. 2016;22:319-31 pubmed
    ..of 18 selected genes (RHO, OPN1LW, OPN1MW, RLBP1, RPGRORF15, RAB8A, RPGRIP1L, CEP290, CC2D2A, DFNB31, RAB11B, CRX, RCVRN, PVALB, CALB1, FGFR1, NTRK2, and NTRK3) involved in neuronal function...
  24. Vasta G, Feng C, Bianchet M, Bachvaroff T, Tasumi S. Structural, functional, and evolutionary aspects of galectins in aquatic mollusks: From a sweet tooth to the Trojan horse. Fish Shellfish Immunol. 2015;46:94-106 pubmed publisher
    ..affinity for β-galactosides and a unique binding site sequence motif in the carbohydrate recognition domain (CRD)...
  25. Wongpanya R, Sengprasert P, Amparyup P, Tassanakajon A. A novel C-type lectin in the black tiger shrimp Penaeus monodon functions as a pattern recognition receptor by binding and causing bacterial agglutination. Fish Shellfish Immunol. 2017;60:103-113 pubmed publisher
    ..The deduced protein contains a single carbohydrate recognition domain (CRD) and four conserved cysteine residues (Cys58, Cys126, Cys141, Cys149) ..
  26. Lu J, Yu Z, Mu C, Li R, Song W, Wang C. Characterization and functional analysis of a novel C-type lectin from the swimming crab Portunus trituberculatus. Fish Shellfish Immunol. 2017;64:185-192 pubmed publisher
    ..A C-type lectin carbohydrate-recognition domain (CRD) containing four conserved cysteines was identified in the amino acid sequence of PtCTL1...
  27. Nakamura M, Ito S, Miyake Y. Novel de novo mutation in CRX gene in a Japanese patient with leber congenital amaurosis. Am J Ophthalmol. 2002;134:465-7 pubmed
    To report a novel de novo mutation in the cone-rod homeobox (CRX) gene in a Japanese patient with Leber congenital amaurosis (LCA). The CRX gene was analyzed by direct genomic sequencing in a patient with LCA and in his healthy parents...
  28. Vitale V, Monami M, Mannucci E. Prostanoids in patients with peripheral arterial disease: A meta-analysis of placebo-controlled randomized clinical trials. J Diabetes Complications. 2016;30:161-6 pubmed publisher
    ..The review protocol was published on http://www.crd.york.ac.uk/prospero (CRD42015020258)...
  29. Dong L, Liang X, Sun B, Ding X, Han H, Zhang G, et al. Impairments of the primary afferent nerves in a rat model of diabetic visceral hyposensitivity. Mol Pain. 2015;11:74 pubmed publisher
    ..Here, we compared the colorectal distension (CRD)-induced visceromotor response (VMR, an index of visceral pain) in vivo, the mechanosensitivity of colonic ..
  30. Tzogani K, Camarero Jiménez J, Garcia I, Sancho López A, Martin M, Moreau A, et al. The European Medicines Agency Review of Carfilzomib for the Treatment of Adult Patients with Multiple Myeloma Who Have Received at Least One Prior Therapy. Oncologist. 2017;22:1339-1346 pubmed publisher
    ..survival (PFS) for patients treated with carfilzomib in combination with lenalidomide and dexamethasone (CRd) was 26.3 months versus 17.6 months for those receiving lenalidomide and dexamethasone alone (hazard ratio = 0...
  31. Dzomba A, Govender K, Mashamba Thompson T, Tanser F. Mobility and increased risk of HIV acquisition in South Africa: a mixed-method systematic review protocol. Syst Rev. 2018;7:37 pubmed publisher
    ..Our protocol was registered with PROSPERO under registration number: CRD 42017055580. ( https://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42017055580 ).
  32. Cremers F, van de Pol D, van Driel M, den Hollander A, van Haren F, Knoers N, et al. Autosomal recessive retinitis pigmentosa and cone-rod dystrophy caused by splice site mutations in the Stargardt's disease gene ABCR. Hum Mol Genet. 1998;7:355-62 pubmed
    ..in a consanguineous family with individuals showing either retinitis pigmentosa (RP) or cone-rod dystrophy (CRD)...
  33. Wang P, Guo X, Zhang Q. Further evidence of autosomal-dominant Leber congenital amaurosis caused by heterozygous CRX mutation. Graefes Arch Clin Exp Ophthalmol. 2007;245:1401-2 pubmed
  34. Maeda H, Miyata T, Kusakisako K, Galay R, Talactac M, Umemiya Shirafuji R, et al. A novel C-type lectin with triple carbohydrate recognition domains has critical roles for the hard tick Haemaphysalis longicornis against Gram-negative bacteria. Dev Comp Immunol. 2016;57:38-47 pubmed publisher
    ..Interestingly, HlCLec possesses three dissimilar carbohydrate recognition domains (CRDs). Each CRD contains the mutated motif of Ca(2+)-binding site 2...
  35. Fang Z, Li D, Li X, Zhang X, Zhu Y, Li W, et al. A single CRD C-type lectin from Eriocheir sinensis (EsLecB) with microbial-binding, antibacterial prophenoloxidase activation and hem-encapsulation activities. Fish Shellfish Immunol. 2016;50:175-90 pubmed publisher
    ..sinensis. ..
  36. Thysen S, Cailotto F, Lories R. Osteogenesis induced by frizzled-related protein (FRZB) is linked to the netrin-like domain. Lab Invest. 2016;96:570-80 pubmed publisher
    ..frizzled-related protein-3 (SFRP3)) is a Wnt modulator that contains an amino-terminal cysteine-rich domain (CRD) and a carboxy-terminal Netrin-like (NTN) motif. Frzb(-/-) mice show increased cortical thickness...
  37. Cao Z, Guo X. The role of galectin-4 in physiology and diseases. Protein Cell. 2016;7:314-24 pubmed publisher
    ..a tandem repeat member of the ?-galactoside-binding proteins, possesses two carbohydrate-recognition domains (CRD) in a single peptide chain...
  38. Byrne E, Sircar R, Miller P, Hedger G, Luchetti G, Nachtergaele S, et al. Structural basis of Smoothened regulation by its extracellular domains. Nature. 2016;535:517-522 pubmed publisher
    ..GPCRs) composed of both a heptahelical transmembrane domain (TMD) and an extracellular cysteine-rich domain (CRD). How the large extracellular domains of GPCRs regulate signalling by the TMD is unknown...
  39. Fattore E, Botta F, Agostoni C, Bosetti C. Effects of free sugars on blood pressure and lipids: a systematic review and meta-analysis of nutritional isoenergetic intervention trials. Am J Clin Nutr. 2017;105:42-56 pubmed publisher
    ..Further independent trials are required to assess whether the reduction of free sugars improves cardiovascular disease risk factors. This review was registered at http://www.crd.york.ac.uk/prospero as CRD42016042930.
  40. Paunescu K, Preising M, Janke B, Wissinger B, Lorenz B. Genotype-phenotype correlation in a German family with a novel complex CRX mutation extending the open reading frame. Ophthalmology. 2007;114:1348-1357.e1 pubmed
    To describe the genotype-phenotype correlation in a German family with a novel CRX mutation and to perform a comparative analysis of published cases...
  41. Casella G, Di Bella C, Salemme M, Villanacci V, Antonelli E, Baldini V, et al. Celiac disease, non-celiac gluten sensitivity and inflammatory bowel disease. Minerva Gastroenterol Dietol. 2015;61:267-71 pubmed
    Celiac disease (CD) and inflammatory bowel disease (IBD), such as Crohn's disease (CrD) and ulcerative colitis (UC), are chronic inflammatory condition of the gastro-intestinal tract...
  42. Brunner S, Stecher L, Ziebarth S, Nehring I, Rifas Shiman S, Sommer C, et al. Excessive gestational weight gain prior to glucose screening and the risk of gestational diabetes: a meta-analysis. Diabetologia. 2015;58:2229-37 pubmed publisher
    ..Avoiding excessive weight gain in pregnancy prior to the GDM screening test may be a potential strategy to reduce GDM risk. META-ANALYSIS REGISTRATION: www.crd.york.ac.uk/PROSPERO CRD42014008802.
  43. Samah S, Fatah C, Jean Marc B, Safia K, Fatima L. Purification and characterization of Cc-Lec, C-type lactose-binding lectin: A platelet aggregation and blood-clotting inhibitor from Cerastes cerastes venom. Int J Biol Macromol. 2017;102:336-350 pubmed publisher
    ..3310-4μg/mL and ki=14.4μg/mL. It seems to interact with these targets through CRD domain which could make it a good target as a pharmacological promising molecule in thrombosis diagnosis and ..
  44. Zheng W, Cai D, Yang X, Ungvari G, Ng C, Muller N, et al. Adjunctive celecoxib for schizophrenia: A meta-analysis of randomized, double-blind, placebo-controlled trials. J Psychiatr Res. 2017;92:139-146 pubmed publisher
    ..Adjunctive celecoxib appears to be an efficacious and safe treatment in improving psychotic symptoms, particularly in first-episode schizophrenia. CRD42016054233 (http://www.crd.york.ac.uk/prospero/).
  45. Stingl K, Mayer A, Llavona P, Mulahasanovic L, Rudolph G, Jacobson S, et al. CDHR1 mutations in retinal dystrophies. Sci Rep. 2017;7:6992 pubmed publisher
    ..ophthalmic and genetic findings in patients with autosomal recessive retinitis pigmentosa (RP), cone-rod dystrophy (CRD) or cone dystrophy (CD) harboring potential pathogenic variants in the CDHR1 gene...
  46. Gottlieb C, Zhang S, Linder M. The Cysteine-rich Domain of the DHHC3 Palmitoyltransferase Is Palmitoylated and Contains Tightly Bound Zinc. J Biol Chem. 2015;290:29259-69 pubmed publisher
    ..mammalian DHHC protein family, all of which contain a conserved catalytic domain called the cysteine-rich domain (CRD)...
  47. Huang X, Feng J, Jin M, Ren Q, Wang W. C-type lectin (MrCTL) from the giant freshwater prawn Macrobrachium rosenbergii participates in innate immunity. Fish Shellfish Immunol. 2016;58:136-144 pubmed publisher
    ..In this study, a novel CTL with a single carbohydrate recognition domain (CRD) containing an EPN (Glu-Pro-Asn) motif was identified from the giant freshwater prawn Macrobrachium rosenbergii...
  48. Zhang P, Xu Q, Xue L, Zheng H, Yan J, Xiao Y, et al. Neonatal Maternal Deprivation Enhances Presynaptic P2X7 Receptor Transmission in Insular Cortex in an Adult Rat Model of Visceral Hypersensitivity. CNS Neurosci Ther. 2017;23:145-154 pubmed publisher
    ..Visceral hypersensitivity was quantified by abdominal withdrawal reflex threshold to colorectal distension (CRD). Expression of P2X7Rs was determined by qPCR and Western blot...
  49. Zhang X, Mofers A, Hydbring P, Olofsson M, Guo J, Linder S, et al. MYC is downregulated by a mitochondrial checkpoint mechanism. Oncotarget. 2017;8:90225-90237 pubmed publisher
    ..We also identified let-7-dependent downregulation of the MYC mRNA chaperone, CRD-BP (coding region determinant-binding protein) as an additional control following mitochondria damage...
  50. Wyatt K, List B, Brinkman W, Prutsky Lopez G, Asi N, Erwin P, et al. Shared Decision Making in Pediatrics: A Systematic Review and Meta-analysis. Acad Pediatr. 2015;15:573-83 pubmed publisher
    ..PROSPERO CRD42013004761 (http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42013004761).
  51. Andrabi Y, Saadeh T, Uppot R, Arellano R, Sahani D. Impact of Dose-Modified Protocols on Radiation Doses in Patients Undergoing CT Examinations following Image-Guided Catheter Placement. J Vasc Interv Radiol. 2015;26:1339-46.e1 pubmed publisher
    ..1 examinations per patient; range, 2-6), the observed cumulative radiation dose (CRD) was 42.1% lower than the expected CRD (observed, 1,437.9 mGy·cm; expected, 2,483.6 mGy·cm; P < .0001)...
  52. Gonzalez F, Veneziano M, Puggina A, Boccia S. A Systematic Review on the Cost-Effectiveness of Genetic and Electrocardiogram Testing for Long QT Syndrome in Infants and Young Adults. Value Health. 2015;18:700-8 pubmed publisher
    ..of genetic and ECG screening strategies for the early detection of LQTS using MEDLINE, EMBASE, and CRD databases between 2000 and 2013...
  53. Carreiro Martins P, Rosado Pinto J, do Céu Teixeira M, Neuparth N, Silva O, Papoila A, et al. Distribution and etiology of chronic respiratory diseases in primary healthcare departments in Cape Verde. Rev Epidemiol Sante Publique. 2015;63:305-13 pubmed publisher
    Data on chronic respiratory diseases (CRD) are scarce or unavailable in most African countries. We aimed to determine the prevalence of CRD and associated risk factors in Cape Verde, at the primary healthcare level...
  54. Wong S, Jamous A, O Driscoll J, Sekhar R, Saif M, O Driscoll S, et al. Effectiveness of probiotic in preventing and treating antibiotic-associated diarrhoea and/or Clostridium difficile-associated diarrhoea in patients with spinal cord injury: a protocol of systematic review of randomised controlled trials. Syst Rev. 2015;4:170 pubmed publisher
    ..following databases will be searched for relevant studies: Cochrane Library; Centre for Reviews and Dissemination (CRD) Database; CINAHL; PsycINFO; Embase; Medline; AMED; International Clinical Trials Registry Platform Search Portal ..
  55. Lelaidier T, Lünskens T, von Weber A, Leoni T, Ranguis A, D Aléo A, et al. Optical and morphological properties of thin films of bis-pyrenyl π-conjugated molecules. Phys Chem Chem Phys. 2016;18:5299-305 pubmed publisher
    ..bis-pyrene) has been studied by the means of surface cavity ring-down (s-CRD) spectroscopy on an amorphous BK7 glass substrate and scanning tunnelling microscopy (STM) on Au(111)...
  56. Pavanello S, Bonzini M, Angelici L, Motta V, Pergoli L, Hoxha M, et al. Extracellular vesicle-driven information mediates the long-term effects of particulate matter exposure on coagulation and inflammation pathways. Toxicol Lett. 2016;259:143-150 pubmed publisher
    ..to public health as it coherently links with increased morbidity and mortality of cardiorespiratory diseases (CRD), and of type 2 diabetes (T2D)...
  57. Fukuda T, Ishizawa Y, Donai K, Sugano E, Tomita H. The poly-cistronic expression of four transcriptional factors (CRX, RAX, NEURO-D, OTX2) in fibroblasts via retro- or lentivirus causes partial reprogramming into photoreceptor cells. Cell Biol Int. 2018;42:608-614 pubmed publisher
    The introduction of four key transcriptional factors (CRX, RAX, NEURO-D, OTX2) allows the direct differentiation of fibroblasts to retinal photoreceptor cells. This reprogramming was achieved with a combination of mono-cistronic viruses...
  58. Garancher A, Lin C, Morabito M, Richer W, Rocques N, Larcher M, et al. NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma. Cancer Cell. 2018;33:435-449.e6 pubmed publisher
    ..We establish that two photoreceptor-specific transcription factors, NRL and CRX, are master regulators of this program and are required for tumor maintenance in this subgroup...
  59. Lahue B, Baginska E, Li S, Parisi M. Health technology assessment on cervical cancer screening, 2000-2014. Int J Technol Assess Health Care. 2015;31:171-80 pubmed publisher
    ..The Center for Reviews and Dissemination (CRD), MedLine, and national HTA agency databases were searched using keywords ("cervical cancer screening" OR "cervical ..
  60. Barroso Neto I, Delatorre P, Teixeira C, Correia J, Cajazeiras J, Pereira R, et al. Structural analysis of a Dioclea sclerocarpa lectin: Study on the vasorelaxant properties of Dioclea lectins. Int J Biol Macromol. 2016;82:464-70 pubmed publisher
    ..The DSL relaxation mechanism relies on nitric oxide production and carbohydrate recognition domain (CRD)...
  61. Shen C, Han J, Wang S, Chung E, Chyu M, Cao J. Green tea supplementation benefits body composition and improves bone properties in obese female rats fed with high-fat diet and caloric restricted diet. Nutr Res. 2015;35:1095-105 pubmed publisher
    ..bone properties, and serum markers in obese rats fed a high-fat diet (HFD) or a caloric restricted diet (CRD)...
  62. Barboza L, Lívero F, Prando T, Ribeiro R, Lourenço E, Budel J, et al. Atheroprotective effects of Cuphea carthagenensis (Jacq.) J. F. Macbr. in New Zealand rabbits fed with cholesterol-rich diet. J Ethnopharmacol. 2016;187:134-45 pubmed publisher
    ..ES-CC) in an experimental atherosclerosis model using New Zealand (NZ) rabbits undergoing cholesterol-rich diet (CRD)...
  63. Hammersley M, Jones R, Okely A. Parent-Focused Childhood and Adolescent Overweight and Obesity eHealth Interventions: A Systematic Review and Meta-Analysis. J Med Internet Res. 2016;18:e203 pubmed publisher
    ..PROSPERO International Prospective Register of Systematic Reviews: CRD42015019837; http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42015019837 (Archived by WebCite at http://www.webcitation...
  64. Wang H, Gu J, Hou X, Chen J, Yang N, Liu Y, et al. Anti-inflammatory effect of miltirone on inflammatory bowel disease via TLR4/NF-?B/IQGAP2 signaling pathway. Biomed Pharmacother. 2017;85:531-540 pubmed publisher
    ..The protein and mRNA expressions of TLR4, MyD88, NF-?B p65 were up-regulated by TNBS or LPS stimulation. CRX-526, the TLR4 inhibitor, as well as miltirone could significantly suppress the increased protein and mRNA ..
  65. Sonvenso D, Itikawa E, Santos M, Santos L, Trevisan A, Bianchin M, et al. Systematic review of the efficacy in seizure control and safety of neuronavigation in epilepsy surgery: The need for well-designed prospective studies. Seizure. 2015;31:99-107 pubmed publisher
    ..Systematic review using the electronic databases of Cochrane, CRD, PubMed, Embase, SciELO and LILACS in Portuguese, English and Spanish...
  66. McGirr A, Vöhringer P, Ghaemi S, Lam R, Yatham L. Safety and efficacy of adjunctive second-generation antidepressant therapy with a mood stabiliser or an atypical antipsychotic in acute bipolar depression: a systematic review and meta-analysis of randomised placebo-controlled trials. Lancet Psychiatry. 2016;3:1138-1146 pubmed publisher
    ..This study is registered with PROSPERO, number CRD#42015016024. We identified six trials representing 1383 patients with bipolar depression...
  67. Testa F, Filippelli M, Brunetti Pierri R, Di Fruscio G, Di Iorio V, Pizzo M, et al. Mutations in the PCYT1A gene are responsible for isolated forms of retinal dystrophy. Eur J Hum Genet. 2017;25:651-655 pubmed publisher
    ..linked to two different phenotypes: one characterized by spondylometaphyseal dysplasia and cone-rod dystrophy (SMD-CRD) and the other by congenital lipodystrophy, severe fatty liver disease, and reduced HDL cholesterol without any ..
  68. Ornelas A, de Paula R, Morais E, Magalhaes L, da Silva A, Gomes M, et al. Molecular characterization of transport lectin vesicular integral membrane protein 36 kDa (VIP36) in the life cycle of Schistosoma mansoni. Parasitol Res. 2017;116:2765-2773 pubmed publisher
    ..Additionally, it was also observed that its CRD contains calcium ion-binding amino acids, suggesting that the binding of SmVIP36 to glycoproteins is calcium-..
  69. Matsui R, McGuigan Iii D, Gruzensky M, Aleman T, Schwartz S, Sumaroka A, et al. SPATA7: Evolving phenotype from cone-rod dystrophy to retinitis pigmentosa. Ophthalmic Genet. 2016;37:333-8 pubmed publisher
    ..The disease resulting from SPATA7 mutations in this patient initially presented as a cone-rod dystrophy (CRD), but changed over time into a phenotype more reminiscent of late-stage retinitis pigmentosa (RP)...
  70. Zhang H, Al Chaer E, Willis W. Effect of tactile inputs on thalamic responses to noxious colorectal distension in rat. J Neurophysiol. 2002;88:1185-96 pubmed
    ..Noxious visceral stimulation was achieved by reproducible colorectal distension (CRD, 20-80 mmHg) with a balloon catheter...
  71. Ścieżyńska A, Oziębło D, Ambroziak A, Korwin M, Szulborski K, Krawczyński M, et al. Next-generation sequencing of ABCA4: High frequency of complex alleles and novel mutations in patients with retinal dystrophies from Central Europe. Exp Eye Res. 2016;145:93-99 pubmed publisher
    ..studies were performed to identify patients with Stargardt disease (STGD, n = 76) and cone-rod dystrophy (CRD, n = 16). Next-generation sequencing targeting ABCA4 was applied for a widespread screening of the gene...
  72. Pinto Junior V, Santiago M, Nobre C, Osterne V, Leal R, Cajazeiras J, et al. Crystal structure of Pisum arvense seed lectin (PAL) and characterization of its interaction with carbohydrates by molecular docking and dynamics. Arch Biochem Biophys. 2017;630:27-37 pubmed publisher
    ..Carbohydrate-recognition domain (CRD) in-depth analysis was performed by MD, describing the behavior of CRD residues in complex with ligand, stability, ..
  73. Nerlekar N, Brown A, Muthalaly R, Talman A, Hettige T, Cameron J, et al. Association of Epicardial Adipose Tissue and High-Risk Plaque Characteristics: A Systematic Review and Meta-Analysis. J Am Heart Assoc. 2017;6: pubmed publisher
    ..URL: https://www.crd.york.ac.uk/. Unique identifier: CRD42017055473.
  74. Xia H, Yan X, Liu Y, Ju P, Liu J, Ni D, et al. Six2 is involved in GATA1-mediated cell apoptosis in mouse embryonic kidney-derived cell lines. In Vitro Cell Dev Biol Anim. 2017;53:827-833 pubmed publisher
    ..However, the underlying regulatory mechanisms of Six2 remain largely unknown. In this study, we predicted that CRX, GATA1, HOXD8, and POU2F2 might target, binding to the promoter region of Six2 (~2000 bp) by bioinformatics ..
  75. Sharon D, Wimberg H, Kinarty Y, Koch K. Genotype-functional-phenotype correlations in photoreceptor guanylate cyclase (GC-E) encoded by GUCY2D. Prog Retin Eye Res. 2018;63:69-91 pubmed publisher
    ..LCA-causing mutations either show reduced ability or complete inability to synthesize cGMP from GTP, while CRD-causing mutations are functional, but shift the Ca2+-sensitivity of the GC-E - GCAP complex...
  76. Gonzalez Ericsson P, Estrada M, Al Rohil R, Sanders M. Post-irradiation morphoea of the breast: a case report and review of the literature. Histopathology. 2017;: pubmed publisher
    ..lymphoedema and cellulitis in the early inflammatory phase, and recurrent breast cancer, chronic radiodermatitis (CRD), radiation-induced fibrosis (RIF), post-irradiation pseudosclerodermatous panniculitis (PIPP), atypical vascular ..
  77. Mehmood K, Akhtar D, Mackedenski S, Wang C, Lee C. Inhibition of GLI1 Expression by Targeting the CRD-BP-GLI1 mRNA Interaction Using a Specific Oligonucleotide. Mol Pharmacol. 2016;89:606-17 pubmed publisher
    The stabilization of glioma-associated oncogene 1 (GLI1) mRNA by coding region determinant binding protein (CRD-BP) through the Wnt/?-catenin signaling pathway is implicated in the proliferation of colorectal cancer and basal cell ..
  78. Ademi Z, Sutherland C, Van Stiphout J, Michaud J, Tanackovic G, Schwenkglenks M. A systematic review of cost-effectiveness analysis of screening interventions for assessing the risk of venous thromboembolism in women considering combined oral contraceptives. J Thromb Thrombolysis. 2017;44:494-506 pubmed publisher
    ..A search strategy using MeSH terms was performed in MEDLINE, Embase, the Centre for Review and Dissemination (CRD) database including the Economic Evaluation Database from the UK National Health Service, and Cochrane reviews...
  79. Song H, Rossi E, Stone E, Latchney L, Williams D, Dubra A, et al. Phenotypic diversity in autosomal-dominant cone-rod dystrophy elucidated by adaptive optics retinal imaging. Br J Ophthalmol. 2017;: pubmed publisher
    Several genes causing autosomal-dominant cone-rod dystrophy (AD-CRD) have been identified. However, the mechanisms by which genetic mutations lead to cellular loss in human disease remain poorly understood...
  80. Adedokun S, Pescatore A, Ford M, Ao T, Jacob J. Investigating the effect of dietary calcium levels on ileal endogenous amino acid losses and standardized ileal amino acid digestibility in broilers and laying hens. Poult Sci. 2017;: pubmed publisher
    ..A total of 384 male Cobb 500 BR and 288 LH were used in a completely randomized design (CRD) with 16 (BR) or 12 (LH) replicate cages with 6 birds/replicate...
  81. Morgenthaler C, Diribarne M, Capitan A, Legendre R, Saintilan R, Gilles M, et al. A missense variant in the coil1A domain of the keratin 25 gene is associated with the dominant curly hair coat trait (Crd) in horse. Genet Sel Evol. 2017;49:85 pubmed publisher
    ..We identified the KRT25:p.R89H variant as responsible for the dominant curly trait, but a second dominant locus may also be involved in the shape of hairs within North American Curly horses. ..
  82. Evans K, Fryer A, Inglehearn C, Duvall Young J, Whittaker J, Gregory C, et al. Genetic linkage of cone-rod retinal dystrophy to chromosome 19q and evidence for segregation distortion. Nat Genet. 1994;6:210-3 pubmed
    ..Multipoint analysis gave a maximum lod score of 10.08 (theta = 0.05) distal to D19S47. Cone-rod dystrophy is therefore assigned to 19q13.1-q13.2 and a new candidate locus for other retinal dystrophies is identified. ..
  83. Mitton K, Swain P, Chen S, Xu S, Zack D, Swaroop A. The leucine zipper of NRL interacts with the CRX homeodomain. A possible mechanism of transcriptional synergy in rhodopsin regulation. J Biol Chem. 2000;275:29794-9 pubmed
    ..NRL (neural retina leucine zipper) and CRX (cone rod homeobox) proteins bind to the adjacent NRE and Ret-4 sites, respectively, within this region...
  84. Jones K, Wheaton D, Bowne S, Sullivan L, Birch D, Chen R, et al. Next-generation sequencing to solve complex inherited retinal dystrophy: A case series of multiple genes contributing to disease in extended families. Mol Vis. 2017;23:470-481 pubmed
    ..retinal gene-targeted NGS testing determined that the proband also harbored a multiple exon deletion in the CRX gene likely accounting for her cone-rod phenotype; her son harbored only the mutation in CRX, not the ..
  85. Utarabhand P, Thepnarong S, Runsaeng P. Lipopolysaccharide-specific binding C-type lectin with one CRD domain from Fenneropenaeus merguiensis (FmLC4) functions as a pattern recognition receptor in shrimp innate immunity. Fish Shellfish Immunol. 2017;69:236-246 pubmed publisher
    ..harveyi. Altogether, FmLC4 may serve as LPS-specific PRR to recognize opportunistic bacterial and viral pathogens, and thus to play a role in the immune defense of aquatic shrimp via the binding and agglutination. ..
  86. Xu S, Qin B, Shi A, Zhao J, Guo X, Dong L. Oxytocin inhibited stress induced visceral hypersensitivity, enteric glial cells activation, and release of proinflammatory cytokines in maternal separated rats. Eur J Pharmacol. 2018;818:578-584 pubmed publisher
    ..After assessing a baseline visceromotor response (VMR) to colorectal distension (CRD), rats were exposed to a 1h water avoidance stress (WAS) session...
  87. Kimura A, Singh D, Wawrousek E, Kikuchi M, Nakamura M, Shinohara T. Both PCE-1/RX and OTX/CRX interactions are necessary for photoreceptor-specific gene expression. J Biol Chem. 2000;275:1152-60 pubmed
    ..RX is found in many retinal cell types including photoreceptor cells. Another homeodomain-containing protein, CRX, which binds to the OTX element to stimulate promoter activity, is found exclusively in photoreceptor cells (Chen, ..
  88. Wang Q, Chen S, Esumi N, Swain P, Haines H, Peng G, et al. QRX, a novel homeobox gene, modulates photoreceptor gene expression. Hum Mol Genet. 2004;13:1025-40 pubmed
    ..QRX synergistically increases the transactivating function of the photoreceptor transcription factors Crx and NRL and it physically interacts with CRX...
  89. Jia Z, Zhang H, Jiang S, Wang M, Wang L, Song L. Comparative study of two single CRD C-type lectins, CgCLec-4 and CgCLec-5, from pacific oyster Crassostrea gigas. Fish Shellfish Immunol. 2016;59:220-232 pubmed publisher
    ..In the present study, two single CRD C-type lectins, CgCLec-4 and CgCLec-5, were identified from oyster Crassostrea gigas...
  90. Sullivan C, Kümper M, Temple B, Maness P. The Neural Cell Adhesion Molecule (NCAM) Promotes Clustering and Activation of EphA3 Receptors in GABAergic Interneurons to Induce Ras Homolog Gene Family, Member A (RhoA)/Rho-associated protein kinase (ROCK)-mediated Growth Cone Collapse. J Biol Chem. 2016;291:26262-26272 pubmed
    ..demonstrated that binding of NCAM and EphA3 occurred between the NCAM Ig2 domain and EphA3 cysteine-rich domain (CRD)...
  91. Zhou J, Wang C. An Ultra-Low Power Turning Angle Based Biomedical Signal Compression Engine with Adaptive Threshold Tuning. Sensors (Basel). 2017;17: pubmed publisher
    ..ECG compression engines, the proposed design has significantly lower power consumption while achieving similar CRD and PRD, making it suitable for long-term wearable miniaturized sensor systems to sense and collect healthcare data ..
  92. Miller M, Zheng Y, Yan J, Zhou Y, Tai G, Mayo K. Novel polysaccharide binding to the N-terminal tail of galectin-3 is likely modulated by proline isomerization. Glycobiology. 2017;27:1038-1051 pubmed publisher
    ..provide epitopes for binding to three sites on 15N-labeled Gal-3, two within its carbohydrate recognition domain (CRD) and one at a novel site within the NT encompassing the first 40 residues that are highly conserved among all ..