Gene Symbol: CRP2BP
Description: lysine acetyltransferase 14
Alias: ATAC2, CRP2BP, CSRP2BP, PRO1194, dJ717M23.1, cysteine-rich protein 2-binding protein, ADA2A-containing complex subunit 2, ATAC component 2 homolog, CRP2 binding partner, CRP2 binding protein, CSRP2-binding protein
Wang K, Zhang H, Bloss C, Duvvuri V, Kaye W, Schork N, et al
. A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa. Mol Psychiatry. 2011;16:949-59 pubmed publisher
..no SNPs reached genome-wide significance in our data, whereas top association signals were detected near ZNF804B, CSRP2BP, NTNG1, AKAP6 and CDH9...
Sanchez Castro M, Eldjouzi H, Charpentier E, Busson P, Hauet Q, Lindenbaum P, et al
. Search for Rare Copy-Number Variants in Congenital Heart Defects Identifies Novel Candidate Genes and a Potential Role for FOXC1 in Patients With Coarctation of the Aorta. Circ Cardiovasc Genet. 2016;9:86-94 pubmed publisher
..We identified 113 candidate genes for congenital heart defects within these CNVs, including BTRC, CHRNB3, CSRP2BP, ERBB2, ERMARD, GLIS3, PLN, PTPRJ, RLN3, and TCTE3...
Ma Y, Li Q, Li A, Wei Y, Long P, Jiang X, et al
. The CSRP2BP histone acetyltransferase drives smooth muscle gene expression. Nucleic Acids Res. 2017;45:3046-3058 pubmed publisher
..Here, we report that CSRP2BP, a coactivator for CRP2, is a histone acetyltransferase and a driver of smooth muscle gene expression...
Shen A, Moran S, Glover E, Drinkwater N, Swearingen R, Teixeira L, et al
. Association of a Chromosomal Rearrangement Event with Mouse Posterior Polymorphous Corneal Dystrophy and Alterations in Csrp2bp, Dzank1, and Ovol2 Gene Expression. PLoS ONE. 2016;11:e0157577 pubmed publisher
..9 Mbp chromosomal inversion flanked by 81 Kbp and 542 bp deletions. This recombination event leads to deletion of Csrp2bp Exons 8 through 11, Dzank1 Exons 20 and 21, and the pseudogene Znf133...
Weiskirchen R, Gressner A. The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP). Biochem Biophys Res Commun. 2000;274:655-63 pubmed
..This protein, designated CRP2BP (for CRP2 binding partner), was previously postulated by sequencing contigs of human chromosome 20...
Wang Y, Faiola F, Xu M, Pan S, Martinez E. Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. J Biol Chem. 2008;283:33808-15 pubmed publisher
..These results suggest that vertebrate ATAC-type and STAGA-type complexes link specific extracellular signals to modification of chromatin structure and regulation of the basal transcription machinery. ..
Guelman S, Kozuka K, Mao Y, Pham V, Solloway M, Wang J, et al
. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Mol Cell Biol. 2009;29:1176-88 pubmed publisher
..report the characterization of a novel mammalian HAT complex, which contains the two acetyltransferases GCN5 and ATAC2 as well as other proteins linked to chromatin metabolism...
Gan Q, Thiebaud P, Theze N, Jin L, Xu G, Grant P, et al
. WD repeat-containing protein 5, a ubiquitously expressed histone methyltransferase adaptor protein, regulates smooth muscle cell-selective gene activation through interaction with pituitary homeobox 2. J Biol Chem. 2011;286:21853-64 pubmed publisher
..Taken together, studies provide evidence for a novel mechanism for epigenetic control of SMC-marker gene expression during development through interaction of WDR5, homeodomain proteins, and chromatin remodeling enzymes. ..