CRP

Summary

Gene Symbol: CRP
Description: C-reactive protein
Alias: PTX1, C-reactive protein, C-reactive protein, pentraxin-related, pentraxin 1
Species: human
Products:     CRP

Top Publications

  1. Wolford J, Gruber J, Ossowski V, Vozarova B, Antonio Tataranni P, Bogardus C, et al. A C-reactive protein promoter polymorphism is associated with type 2 diabetes mellitus in Pima Indians. Mol Genet Metab. 2003;78:136-44 pubmed
    ..Results from recent prospective studies indicate that increased levels of C-reactive protein (CRP), a marker of immune system activation, are predictive of diabetes, independent of adiposity...
  2. Giha H, Nasr A, Ekström M, Israelsson E, Arambepola G, Arnot D, et al. Association of a single nucleotide polymorphism in the C-reactive protein gene (-286) with susceptibility to Plasmodium falciparum malaria. Mol Med. 2010;16:27-33 pubmed publisher
    The role of inflammation in malaria pathogenesis is not fully understood, although C-reactive protein (CRP) may have a negative influence on host immunity to infections...
  3. Thanabalasingham G, Shah N, Vaxillaire M, Hansen T, Tuomi T, Gašperíková D, et al. A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes. Diabetologia. 2011;54:2801-10 pubmed publisher
    ..High-sensitivity CRP levels were analysed in individuals with HNF1A-MODY (n = 457), glucokinase (GCK)-MODY (n =â€..
  4. Welsh P, Polisecki E, Robertson M, Jahn S, Buckley B, de Craen A, et al. Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach. J Clin Endocrinol Metab. 2010;95:93-9 pubmed publisher
    ..In the PROSPER study of 5804 elderly patients, we related C-reactive protein (CRP) single nucleotide polymorphisms (SNPs) (rs1800947 and rs1205) and adiposity SNPs (FTO and MC4R) to body mass index ..
  5. Eiriksdottir G, Smith A, Aspelund T, Hafsteinsdottir S, Olafsdottir E, Launer L, et al. The interaction of adiposity with the CRP gene affects CRP levels: age, gene/environment susceptibilty-Reykjavik study. Int J Obes (Lond). 2009;33:267-72 pubmed publisher
    ..diseases often have an inflammatory component reflected by associated markers such as serum C-reactive protein (CRP) levels...
  6. Elliott P, Chambers J, Zhang W, Clarke R, Hopewell J, Peden J, et al. Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA. 2009;302:37-48 pubmed publisher
    Plasma levels of C-reactive protein (CRP) are independently associated with risk of coronary heart disease, but whether CRP is causally associated with coronary heart disease or merely a marker of underlying atherosclerosis is uncertain...
  7. Abu Farha M, Behbehani K, Elkum N. Comprehensive analysis of circulating adipokines and hsCRP association with cardiovascular disease risk factors and metabolic syndrome in Arabs. Cardiovasc Diabetol. 2014;13:76 pubmed publisher
    ..Overall, our data highlights the significant clinical value these markers have in MetS especially hsCRP which can be used as good marker of low grade inflammation in Arabs. ..
  8. Chocano Bedoya P, Mirzaei F, O Reilly E, Lucas M, Okereke O, Hu F, et al. C-reactive protein, interleukin-6, soluble tumor necrosis factor ? receptor 2 and incident clinical depression. J Affect Disord. 2014;163:25-32 pubmed publisher
    ..We conducted a prospective analysis of blood levels of CRP, IL-6 and TNF?-R2 in 4756 women participating in the Nurses? Health Study who donated blood in 1990 and were ..
  9. Thiele J, Habersberger J, Braig D, Schmidt Y, Goerendt K, Maurer V, et al. Dissociation of pentameric to monomeric C-reactive protein localizes and aggravates inflammation: in vivo proof of a powerful proinflammatory mechanism and a new anti-inflammatory strategy. Circulation. 2014;130:35-50 pubmed publisher
    ..mCRP is proposed as a pathogenic factor in atherosclerosis and myocardial infarction. Most importantly, the inhibition of pCRP dissociation represents a promising, novel anti-inflammatory therapeutic strategy...

More Information

Publications257 found, 100 shown here

  1. Sunyer J, Pistelli R, Plana E, Andreani M, Baldari F, Kolz M, et al. Systemic inflammation, genetic susceptibility and lung function. Eur Respir J. 2008;32:92-7 pubmed publisher
    ..In 134 post-myocardial infarction patients, six repeated measurements of C-reactive protein (CRP), interleukin (IL)-6 and fibrinogen in peripheral blood were assayed using high-sensitivity tests...
  2. Rogus J, Beck J, Offenbacher S, Huttner K, Iacoviello L, Latella M, et al. IL1B gene promoter haplotype pairs predict clinical levels of interleukin-1beta and C-reactive protein. Hum Genet. 2008;123:387-98 pubmed publisher
    ..These findings may apply to other inducible genes and could provide a logical framework for exploring disease risk related to genetic variability in pathogenic mediators. ..
  3. Tennent G, Hutchinson W, Kahan M, Hirschfield G, Gallimore J, Lewin J, et al. Transgenic human CRP is not pro-atherogenic, pro-atherothrombotic or pro-inflammatory in apoE-/- mice. Atherosclerosis. 2008;196:248-55 pubmed
    The pathogenic significance, if any, of the epidemiological association between baseline C-reactive protein (CRP) values and future atherothrombotic events is not known...
  4. Swiatkiewicz I, Kozinski M, Magielski P, Gierach J, Fabiszak T, Kubica A, et al. Usefulness of C-reactive protein as a marker of early post-infarct left ventricular systolic dysfunction. Inflamm Res. 2012;61:725-34 pubmed publisher
    To assess the usefulness of in-hospital measurement of C-reactive protein (CRP) concentration in comparison to well-established risk factors as a marker of post-infarct left ventricular systolic dysfunction (LVSD) at discharge...
  5. Ortiz M, Campana G, Woods J, Boguslawski G, Sosa M, Walker C, et al. Continuously-infused human C-reactive protein is neither proatherosclerotic nor proinflammatory in apolipoprotein E-deficient mice. Exp Biol Med (Maywood). 2009;234:624-31 pubmed publisher
    ..that these disparities are related to (a) the use, in some studies, of contaminated nCRP, or to (b) variation in CRP levels associated with either its episodic administration or the use of CRP-transgenic mice...
  6. Nijmeijer R, Lagrand W, Lubbers Y, Visser C, Meijer C, Niessen H, et al. C-reactive protein activates complement in infarcted human myocardium. Am J Pathol. 2003;163:269-75 pubmed
    Circulating levels of C-reactive protein (CRP) constitute a cardiovascular risk marker...
  7. Szalai A, Alarcon G, Calvo Alen J, Toloza S, McCrory M, Edberg J, et al. Systemic lupus erythematosus in a multiethnic US Cohort (LUMINA). XXX: association between C-reactive protein (CRP) gene polymorphisms and vascular events. Rheumatology (Oxford). 2005;44:864-8 pubmed
    To determine if a polymorphic GTn repeat in the intron of the C-reactive protein (CRP) gene associates with occurrence of vascular arterial events in systemic lupus erythematosus (SLE)...
  8. Memoli B, Procino A, Calabro P, Esposito P, Grandaliano G, Pertosa G, et al. Inflammation may modulate IL-6 and C-reactive protein gene expression in the adipose tissue: the role of IL-6 cell membrane receptor. Am J Physiol Endocrinol Metab. 2007;293:E1030-5 pubmed
    Only few studies have been addressed to the presence and regulation of C-reactive protein (CRP) gene expression in different districts of adipose tissue, and no study has investigated the role of adipose tissue in presence of ..
  9. Singh U, Devaraj S, Vasquez Vivar J, Jialal I. C-reactive protein decreases endothelial nitric oxide synthase activity via uncoupling. J Mol Cell Cardiol. 2007;43:780-91 pubmed
    C-reactive protein (CRP), a cardiovascular risk marker, induces endothelial dysfunction...
  10. Nabata A, Kuroki M, Ueba H, Hashimoto S, Umemoto T, Wada H, et al. C-reactive protein induces endothelial cell apoptosis and matrix metalloproteinase-9 production in human mononuclear cells: Implications for the destabilization of atherosclerotic plaque. Atherosclerosis. 2008;196:129-35 pubmed
    C-reactive protein (CRP) has been suggested to directly induce the inflammatory response leading to the progression of atherosclerosis...
  11. Sander K, Horn C, Briesenick C, Sander D. High-sensitivity C-reactive protein is independently associated with early carotid artery progression in women but not in men: the INVADE Study. Stroke. 2007;38:2881-6 pubmed
    ..Therefore, we investigated the effect of hsCRP on early carotid atherosclerosis progression and major vascular risk factors in men and women...
  12. Zacho J, Tybjaerg Hansen A, Nordestgaard B. C-reactive protein and risk of venous thromboembolism in the general population. Arterioscler Thromb Vasc Biol. 2010;30:1672-8 pubmed publisher
    To examine the robustness of the association between C-reactive protein (CRP) levels and increased risk of venous thromboembolism (VTE) and to examine whether genetically elevated CRP levels cause VTE...
  13. Devaraj S, Singh U, Jialal I. Human C-reactive protein and the metabolic syndrome. Curr Opin Lipidol. 2009;20:182-9 pubmed publisher
    Low-grade inflammation is characteristic of the metabolic syndrome (MetS). C-reactive protein (CRP), the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events...
  14. Hurme M, Kivimaki M, Pertovaara M, Lehtimaki T, Karhunen P, Jylha M, et al. CRP gene is involved in the regulation of human longevity: a follow-up study in Finnish nonagenarians. Mech Ageing Dev. 2007;128:574-6 pubmed
    ..conditions in humans and it is frequently quantified by measuring the blood concentration of C-reactive protein (CRP)...
  15. Carlson C, Aldred S, Lee P, Tracy R, Schwartz S, Rieder M, et al. Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels. Am J Hum Genet. 2005;77:64-77 pubmed
    Elevated plasma levels of C-reactive protein (CRP), an inflammation-sensitive marker, have emerged as an important predictor of future cardiovascular disease and metabolic abnormalities in apparently healthy men and women...
  16. De Rosa S, Cirillo P, Pacileo M, Di Palma V, Paglia A, Chiariello M. Leptin stimulated C-reactive protein production by human coronary artery endothelial cells. J Vasc Res. 2009;46:609-17 pubmed publisher
    ..C-reactive protein (CRP) is a predictor of future cardiovascular events and plays a role in atherothrombotic disease...
  17. Mölkänen T, Rostila A, Ruotsalainen E, Alanne M, Perola M, Jarvinen A. Genetic polymorphism of the C-reactive protein (CRP) gene and a deep infection focus determine maximal serum CRP level in Staphylococcus aureus bacteremia. Eur J Clin Microbiol Infect Dis. 2010;29:1131-7 pubmed publisher
    C-reactive protein (CRP) is widely used in early detection of sepsis or organ dysfunction. Several single nucleotide polymorphisms (SNPs) in the CRP gene are shown to be associated with variability of basal CRP...
  18. Gallicchio L, Chang H, Christo D, Thuita L, Huang H, Strickland P, et al. Single nucleotide polymorphisms in inflammation-related genes and mortality in a community-based cohort in Washington County, Maryland. Am J Epidemiol. 2008;167:807-13 pubmed publisher
    ..IFNgamma), lymphotoxin-alpha (LTalpha), tumor necrosis factor-alpha (TNFalpha), C-reactive protein (CRP), peroxisome proliferator-activated receptor (PPAR), and the human endothelial nitric oxide synthase (eNOS)...
  19. Eklund C, Kivimaki M, Islam M, Juonala M, Kahonen M, Marniemi J, et al. C-reactive protein genetics is associated with carotid artery compliance in men in The Cardiovascular Risk in Young Finns Study. Atherosclerosis. 2008;196:841-8 pubmed
    Although C-reactive protein (CRP) is known to predict cardiovascular events, its status as a causal risk factor is still controversial...
  20. Pegues M, McCrory M, Zarjou A, Szalai A. C-reactive protein exacerbates renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2013;304:F1358-65 pubmed publisher
    ..Inflammation accompanies IRI and increases the blood level of C-reactive protein (CRP), a biomarker of worsened outcomes in AKI...
  21. Casas J, Shah T, Cooper J, Hawe E, McMahon A, Gaffney D, et al. Insight into the nature of the CRP-coronary event association using Mendelian randomization. Int J Epidemiol. 2006;35:922-31 pubmed
    It is unclear wheather the association between C-reactive protein (CRP) and incident coronary events is free from bias and confounding...
  22. King D, Mainous A, Buchanan T, Pearson W. C-reactive protein and glycemic control in adults with diabetes. Diabetes Care. 2003;26:1535-9 pubmed
    ..Studies have indicated that C-reactive protein (CRP) is an important risk factor for cardiovascular disease...
  23. Yanagawa T, Taniguchi A, Fukushima M, Nakai Y, Nagasaka S, Ohgushi M, et al. Leptin, triglycerides, and interleukin 6 are independently associated with C-reactive protein in Japanese type 2 diabetic patients. Diabetes Res Clin Pract. 2007;75:2-6 pubmed
    ..One hundred and 48 Japanese type 2 diabetic patients were studied. In conjunction with C-reactive protein (CRP), BMI, systolic and diastolic blood pressure, glycosylated hemoglobin (HbA1c), fasting concentrations of plasma ..
  24. Molins B, Pena E, de la Torre R, Badimon L. Monomeric C-reactive protein is prothrombotic and dissociates from circulating pentameric C-reactive protein on adhered activated platelets under flow. Cardiovasc Res. 2011;92:328-37 pubmed publisher
  25. Chen J, Zhao J, Huang J, Su S, Qiang B, Gu D. -717A>G polymorphism of human C-reactive protein gene associated with coronary heart disease in ethnic Han Chinese: the Beijing atherosclerosis study. J Mol Med (Berl). 2005;83:72-8 pubmed
    Serum C-reactive protein (CRP) has been strongly implicated in the pathogenesis of coronary heart disease (CHD). We report here on the association between gene coding for CRP and CHD in the ethnic Han population of China...
  26. Okemefuna A, Nan R, Miller A, Gor J, Perkins S. Complement factor H binds at two independent sites to C-reactive protein in acute phase concentrations. J Biol Chem. 2010;285:1053-65 pubmed publisher
    ..The Y402H polymorphism in FH is a risk factor for age-related macular degeneration. C-reactive protein (CRP) is an acute phase protein that binds Ca(2+)...
  27. Yang S, Huang C, Chang S, Lin J. Association of C-reactive protein gene polymorphisms and colorectal cancer. Ann Surg Oncol. 2011;18:1907-15 pubmed publisher
    An elevated plasma level of C-reactive protein (CRP) is a risk for, and prognostic factor of, colorectal cancer (CRC). In other reports of CRP concerning cardiovascular disease, CRP level correlated with its gene polymorphisms...
  28. Yang J, Wezeman M, Zhang X, Lin P, Wang M, Qian J, et al. Human C-reactive protein binds activating Fcgamma receptors and protects myeloma tumor cells from apoptosis. Cancer Cell. 2007;12:252-65 pubmed
    Elevated levels of C-reactive protein (CRP) are present in many disease situations including malignancies and may contribute to the pathogenesis of cardiovascular disorders...
  29. Venugopal S, Devaraj S, Yuhanna I, Shaul P, Jialal I. Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation. 2002;106:1439-41 pubmed
    C-reactive protein (CRP), the prototypic marker of inflammation, has been shown to be an independent predictor of cardiovascular events. Endothelial nitric oxide synthase (eNOS) deficiency is a pivotal event in atherogenesis...
  30. Lu B, Yang Y, Yang Z, Feng X, Wang X, Zhang Z, et al. Insulin resistance in Chinese patients with type 2 diabetes is associated with C-reactive protein independent of abdominal obesity. Cardiovasc Diabetol. 2010;9:92 pubmed publisher
    There is debate as to whether the association between C-reactive protein (CRP) and insulin resistance is independent of body fatness, particularly central obesity...
  31. Gang T, Hammond D, Singh S, Ferguson D, Mishra V, Agrawal A. The phosphocholine-binding pocket on C-reactive protein is necessary for initial protection of mice against pneumococcal infection. J Biol Chem. 2012;287:43116-25 pubmed publisher
    Human C-reactive protein (CRP) protects mice from lethal Streptococcus pneumoniae infection when injected into mice within the range of 6 h before to 2 h after the administration of pneumococci...
  32. Singh P, Hoffmann M, Wolk R, Shamsuzzaman A, Somers V. Leptin induces C-reactive protein expression in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2007;27:e302-7 pubmed
    ..Higher leptin levels are associated with increased levels of C-reactive protein (CRP), which itself elicits proatherogenic effects in the vascular endothelium...
  33. Meuwese C, Snaedal S, Halbesma N, Stenvinkel P, Dekker F, Qureshi A, et al. Trimestral variations of C-reactive protein, interleukin-6 and tumour necrosis factor-? are similarly associated with survival in haemodialysis patients. Nephrol Dial Transplant. 2011;26:1313-8 pubmed publisher
    The impact of intra-individual changes of inflammatory markers [other than C-reactive protein (CRP)] on mortality in haemodialysis (HD) patients is unknown...
  34. Bahceci M, Tuzcu A, Ogun C, Canoruc N, Iltimur K, Aslan C. Is serum C-reactive protein concentration correlated with HbA1c and insulin resistance in Type 2 diabetic men with or without coronary heart disease?. J Endocrinol Invest. 2005;28:145-50 pubmed
    C-reactive protein (CRP) is an inflammatory marker that predicts coronary heart disease (CHD) risk. Diabetes mellitus (DM) counts as a CHD risk equivalent...
  35. Balistreri C, Vasto S, Listi F, Grimaldi M, Lio D, Colonna Romano G, et al. Association between +1059G/C CRP polymorphism and acute myocardial infarction in a cohort of patients from Sicily: a pilot study. Ann N Y Acad Sci. 2006;1067:276-81 pubmed
    ..in all the phases of atherosclerosis, and increased production of the acute-phase reactant, C-reactive protein (CRP), predicts future cardiovascular events...
  36. Zhang L, Kao W, Berthier Schaad Y, Plantinga L, Fink N, Smith M, et al. C-Reactive protein haplotype predicts serum C-reactive protein levels but not cardiovascular disease risk in a dialysis cohort. Am J Kidney Dis. 2007;49:118-26 pubmed
    C-Reactive protein (CRP) gene variation has been associated with serum CRP levels in the general population...
  37. Hefler L, Concin N, Hofstetter G, Marth C, Mustea A, Sehouli J, et al. Serum C-reactive protein as independent prognostic variable in patients with ovarian cancer. Clin Cancer Res. 2008;14:710-4 pubmed publisher
    To evaluate serum C-reactive protein (CRP) as prognostic variable in patients with epithelial ovarian cancer (EOC). In a multicenter study, preoperative serum CRP was evaluated in 623 patients with EOC...
  38. Schneeweis C, Grafe M, Bungenstock A, Spencer Hänsch C, Fleck E, Goetze S. Chronic CRP-exposure inhibits VEGF-induced endothelial cell migration. J Atheroscler Thromb. 2010;17:203-12 pubmed
    C-reactive protein (CRP) is a pluripotent mediator of inflammation and is present at sites of vascular injury and in atherosclerotic lesions...
  39. Zee R, Ridker P. Polymorphism in the human C-reactive protein (CRP) gene, plasma concentrations of CRP, and the risk of future arterial thrombosis. Atherosclerosis. 2002;162:217-9 pubmed
    While increased concentrations of C-reactive protein (CRP) are associated with increased vascular risk, little information is available describing genetic determinants of this effect...
  40. Nozoe T, Korenaga D, Futatsugi M, Saeki H, Maehara Y, Sugimachi K. Immunohistochemical expression of C-reactive protein in squamous cell carcinoma of the esophagus - significance as a tumor marker. Cancer Lett. 2003;192:89-95 pubmed
    C-reactive protein (CRP) is a prototype acute phase protein which has been known to be synthesized in hepatocytes...
  41. Paul A, Ko K, Li L, Yechoor V, McCrory M, Szalai A, et al. C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2004;109:647-55 pubmed
    Plasma C-reactive protein (CRP) concentration is a strong predictor of atherosclerosis. However, to date, there is no in vivo evidence that CRP is proatherogenic...
  42. Bazeley J, Bieber B, Li Y, Morgenstern H, de Sequera P, Combe C, et al. C-reactive protein and prediction of 1-year mortality in prevalent hemodialysis patients. Clin J Am Soc Nephrol. 2011;6:2452-61 pubmed publisher
    Measurement of C-reactive protein (CRP) levels remains uncommon in North America, although it is now routine in many countries...
  43. Rifai N, Ridker P. Inflammatory markers and coronary heart disease. Curr Opin Lipidol. 2002;13:383-9 pubmed
    ..In addition, it may also be a good prognostic indicator in patients with acute coronary syndromes. ..
  44. Reiner A, Barber M, Guan Y, Ridker P, Lange L, Chasman D, et al. Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein. Am J Hum Genet. 2008;82:1193-201 pubmed publisher
    ..common polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha and plasma C-reactive protein (CRP) concentration...
  45. Lawlor D, Harbord R, Timpson N, Lowe G, Rumley A, Gaunt T, et al. The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants. PLoS ONE. 2008;3:e3011 pubmed publisher
    It is unclear whether C-reactive protein (CRP) is causally related to coronary heart disease (CHD). Genetic variants that are known to be associated with CRP levels can be used to provide causal inference of the effect of CRP on CHD...
  46. Ladenvall C, Jood K, Blomstrand C, Nilsson S, Jern C, Ladenvall P. Serum C-reactive protein concentration and genotype in relation to ischemic stroke subtype. Stroke. 2006;37:2018-23 pubmed
    C-reactive protein (CRP) has evolved as an inflammatory risk marker of cardiovascular disease. Several single-nucleotide polymorphisms at the CRP locus have been found to be associated with CRP levels...
  47. Shih H, Zhang S, Cao W, Hahn A, Wang J, Paulsen J, et al. CRP is a novel ligand for the oxidized LDL receptor LOX-1. Am J Physiol Heart Circ Physiol. 2009;296:H1643-50 pubmed publisher
    C-reactive protein (CRP) is a risk factor for cardiovascular events and functions to amplify vascular inflammation through promoting endothelial dysfunction...
  48. Verma S, Wang C, Li S, Dumont A, Fedak P, Badiwala M, et al. A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis. Circulation. 2002;106:913-9 pubmed
    ..of cardiovascular diseases, we sought to determine whether the powerful predictive value of C-reactive protein (CRP) might be explained through an effect on NO production...
  49. Obisesan T, Leeuwenburgh C, Phillips T, Ferrell R, Phares D, Prior S, et al. C-reactive protein genotypes affect baseline, but not exercise training-induced changes, in C-reactive protein levels. Arterioscler Thromb Vasc Biol. 2004;24:1874-9 pubmed
    The goal of this study is to determine whether C-reactive protein (CRP) gene variants affect baseline and training-induced changes in plasma CRP levels...
  50. Best L, Nadeau M, Davis K, Lamb F, Bercier S, Anderson C. Genetic variants, immune function, and risk of pre-eclampsia among American Indians. Am J Reprod Immunol. 2012;67:152-9 pubmed publisher
    ..Although most genetic variants lacked evidence of association with PE, the minor allele of the CRP related, rs1205 SNP in a dominant model with adjustment for age at delivery, nulliparity, and body mass index, ..
  51. Fox E, Benjamin E, Sarpong D, Rotimi C, Wilson J, Steffes M, et al. Epidemiology, heritability, and genetic linkage of C-reactive protein in African Americans (from the Jackson Heart Study). Am J Cardiol. 2008;102:835-41 pubmed publisher
    C-reactive protein (CRP) has been studied largely in white non-Hispanic cohorts. There is limited information on CRP's range of values, heritability, and relation to cardiovascular disease risk factors in African Americans...
  52. Takahashi T, Anzai T, Kaneko H, Mano Y, Anzai A, Nagai T, et al. Increased C-reactive protein expression exacerbates left ventricular dysfunction and remodeling after myocardial infarction. Am J Physiol Heart Circ Physiol. 2010;299:H1795-804 pubmed publisher
    We previously reported serum C-reactive protein (CRP) elevation after acute myocardial infarction (MI) to be associated with adverse outcomes including cardiac rupture, left ventricular (LV) remodeling, and cardiac death...
  53. Malik S, Wong N, Franklin S, Pio J, Fairchild C, Chen R. Cardiovascular disease in U.S. patients with metabolic syndrome, diabetes, and elevated C-reactive protein. Diabetes Care. 2005;28:690-3 pubmed
    C-reactive protein (CRP) independently predicts cardiovascular disease (CVD); whether it can stratify risk in those with metabolic syndrome and diabetes is not well documented...
  54. Wang Q, Zhu X, Xu Q, Ding X, Chen Y, Song Q. Effect of C-reactive protein on gene expression in vascular endothelial cells. Am J Physiol Heart Circ Physiol. 2005;288:H1539-45 pubmed
    C-reactive protein (CRP) is significantly associated with the risk of ischemic cardiovascular disease in epidemiological studies...
  55. Kim I, Ji F, Morrison M, Adams S, Zhang Q, Lane A, et al. Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration. Mol Vis. 2008;14:1487-95 pubmed
    To examine if the gene encoding C-reactive protein (CRP), a biomarker of inflammation, confers risk for neovascular age-related macular degeneration (AMD) in the presence of other modifiers of inflammation, including body mass index (BMI)..
  56. Bochud M, Marquant F, Marques Vidal P, Vollenweider P, Beckmann J, Mooser V, et al. Association between C-reactive protein and adiposity in women. J Clin Endocrinol Metab. 2009;94:3969-77 pubmed publisher
    The link between C-reactive protein (CRP) and adiposity deserves to be further explored, considering the controversial diabetogenic role of CRP. We explored the potential causal role of CRP on measures of adiposity...
  57. Alifano M, Falcoz P, Seegers V, Roche N, Schussler O, Younes M, et al. Preresection serum C-reactive protein measurement and survival among patients with resectable non-small cell lung cancer. J Thorac Cardiovasc Surg. 2011;142:1161-7 pubmed publisher
    This study aimed to determine whether preresection serum CRP level independently predicts survival among patients with resectable non-small cell lung cancer...
  58. Isasi C, Deckelbaum R, Tracy R, Starc T, Berglund L, Shea S. Physical fitness and C-reactive protein level in children and young adults: the Columbia University BioMarkers Study. Pediatrics. 2003;111:332-8 pubmed
    To examine the association of physical fitness with C-reactive protein (CRP) level in children and young adults. Subjects (N = 205) aged 6 to 24 years were enrolled in the Columbia University BioMarkers Study (1994-1998)...
  59. Makita S, Nakamura M, Hiramori K. The association of C-reactive protein levels with carotid intima-media complex thickness and plaque formation in the general population. Stroke. 2005;36:2138-42 pubmed
    ..thickness [IMT] increase, plaque formation, and arterial dilatation) are associated with C-reactive protein (CRP) levels and to determine whether there are any gender differences...
  60. Lin M, Shih S, Li H, Chuang L, Chang T, Wei J, et al. Serum C-reactive protein levels correlates better to metabolic syndrome defined by International Diabetes Federation than by NCEP ATP III in men. Diabetes Res Clin Pract. 2007;77:286-92 pubmed
    ..18, p<0.05, MS by ATP III definition, partial r=0.12, p=0.071). In conclusion, IDF definition of MS has a stronger relationship with serum hsCRP than ATP III definition in men. ..
  61. Yanbaeva D, Dentener M, Spruit M, Houwing Duistermaat J, Kotz D, Passos V, et al. IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study. BMC Med Genet. 2009;10:23 pubmed publisher
    Elevated circulating levels of C-reactive protein (CRP), interleukin (IL)-6 and fibrinogen (FG) have been repeatedly associated with many adverse outcomes in patients with chronic obstructive pulmonary disease (COPD)...
  62. Allin K, Nordestgaard B, Zacho J, Tybjaerg Hansen A, Bojesen S. C-reactive protein and the risk of cancer: a mendelian randomization study. J Natl Cancer Inst. 2010;102:202-6 pubmed publisher
    Elevated plasma levels of C-reactive protein (CRP), a marker of inflammation, are associated with an increased risk of cancer, but it is unclear whether this association is causal...
  63. Dahl M, Vestbo J, Zacho J, Lange P, Tybjærg Hansen A, Nordestgaard B. C reactive protein and chronic obstructive pulmonary disease: a Mendelian randomisation approach. Thorax. 2011;66:197-204 pubmed publisher
    It is unclear whether elevated plasma C reactive protein (CRP) is causally related to chronic obstructive pulmonary disease (COPD)...
  64. Fu T, Borensztajn J. Macrophage uptake of low-density lipoprotein bound to aggregated C-reactive protein: possible mechanism of foam-cell formation in atherosclerotic lesions. Biochem J. 2002;366:195-201 pubmed
    ..C-reactive protein (CRP) is an acute-phase protein found in atherosclerotic lesions, which when immobilized on a solid phase, can bind and ..
  65. Gaysina D, Pierce M, Richards M, Hotopf M, Kuh D, Hardy R. Association between adolescent emotional problems and metabolic syndrome: the modifying effect of C-reactive protein gene (CRP) polymorphisms. Brain Behav Immun. 2011;25:750-8 pubmed publisher
    ..depression and metabolic syndrome are associated with markers of systemic inflammation, such as C-reactive protein (CRP)...
  66. Rizzo M, Corrado E, Coppola G, Muratori I, Mezzani A, Novo G, et al. The predictive role of C-reactive protein in patients with hypertension and subclinical atherosclerosis. Intern Med J. 2009;39:539-45 pubmed publisher
    ..European Society of Hypertension/European Society of Cardiology have suggested the inclusion of C-reactive protein (CRP) in the standard assessment of cardiovascular risk in hypertensive patients, but few data are available on the role ..
  67. Eisenhardt S, Starke J, Thiele J, Murphy A, Björn Stark G, Bassler N, et al. Pentameric CRP attenuates inflammatory effects of mmLDL by inhibiting mmLDL--monocyte interactions. Atherosclerosis. 2012;224:384-93 pubmed publisher
    Previous studies have reported that C-reactive protein (CRP) interacting with low-density lipoproteins (LDL) affects macrophage activation and LDL uptake...
  68. Schulze M, Rimm E, Li T, Rifai N, Stampfer M, Hu F. C-reactive protein and incident cardiovascular events among men with diabetes. Diabetes Care. 2004;27:889-94 pubmed
    Several large prospective studies have shown that baseline levels of C-reactive protein (CRP) are an independent predictor of cardiovascular events among apparently healthy individuals...
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    ..We have previously shown that human C-reactive protein (CRP), the classical acute-phase protein that binds to ligands exposed in damaged tissue and then activates complement, ..
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    ..many studies have found psychological depression associated with higher circulating levels of C-reactive protein (CRP), not all findings are consistent...
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    ..polymorphisms rs5491 on the intercellular adhesive molecule 1 (ICAM1) gene and rs3091244 on C-reactive protein (CRP) were genotyped...
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    ..multiple CV risk factors and/or disease, serum concentrations of IL-6 and high sensitive C-reactive protein (hs-CRP) were measured. During follow-up periods (mean, 2...
  73. Crawford D, Sanders C, Qin X, Smith J, Shephard C, Wong M, et al. Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey. Circulation. 2006;114:2458-65 pubmed
    Increased serum C-reactive protein (CRP) is an independent risk factor for cardiovascular disease. Previous studies have suggested that genetic variation within the CRP gene is associated with serum CRP...
  74. Suk H, Ridker P, Cook N, Zee R. Relation of polymorphism within the C-reactive protein gene and plasma CRP levels. Atherosclerosis. 2005;178:139-45 pubmed
    We sought to investigate whether genetic variability within the CRP gene affects CRP levels. C-reactive protein (CRP), an acute-phase reactant in inflammation, is an important predictor for cardiovascular disease...
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    Although prospective studies have unequivocally shown that C-reactive protein (CRP) is an independent predictor of future cardiovascular events, studies on the association between CRP and atherosclerosis have provided inconsistent ..
  76. Ben Assayag E, Shenhar Tsarfaty S, Bova I, Berliner S, Shopin L, Peretz H, et al. Triggered C-reactive protein (CRP) concentrations and the CRP gene -717A>G polymorphism in acute stroke or transient ischemic attack. Eur J Neurol. 2007;14:315-20 pubmed
    C-reactive protein (CRP) increases following an acute stroke/transient ischemic attack (TIA), but the increment level varies among patients...
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    It remains unclear whether C-reactive protein (CRP) is a serum marker for atherothrombotic disease or a causal factor in the pathogenesis of atherosclerosis...
  78. Ravishankaran P, Karunanithi R. Clinical significance of preoperative serum interleukin-6 and C-reactive protein level in breast cancer patients. World J Surg Oncol. 2011;9:18 pubmed publisher
    Breast cancer is a disease that continues to plague females during their entire lifetime. IL-6 and CRP are found to be elevated in various inflammatory and malignant diseases and their levels are found to correlate with the extent of the ..
  79. Mold C, Rodriguez W, Rodic Polic B, Du Clos T. C-reactive protein mediates protection from lipopolysaccharide through interactions with Fc gamma R. J Immunol. 2002;169:7019-25 pubmed
    C-reactive protein (CRP) is a component of the acute phase response to infection, inflammation, and trauma. A major activity of acute phase proteins is to limit the inflammatory response...
  80. Cunha A, Andreazza A, Gomes F, Frey B, da Silveira L, Gonçalves C, et al. Investigation of serum high-sensitive C-reactive protein levels across all mood states in bipolar disorder. Eur Arch Psychiatry Clin Neurosci. 2008;258:300-4 pubmed publisher
    ..001). These findings add to the notion that changes in the inflammatory system take place during acute episodes of mania. ..
  81. Howren M, Lamkin D, Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med. 2009;71:171-86 pubmed publisher
    To assess the magnitude and direction of associations of depression with C-reactive protein (CRP), interleukin (IL)-1, and IL-6 in community and clinical samples...
  82. Eggers H, Seidel C, Schrader A, Lehmann R, Wegener G, Kuczyk M, et al. Serum C-reactive protein: a prognostic factor in metastatic urothelial cancer of the bladder. Med Oncol. 2013;30:705 pubmed publisher
    ..Recently, serum C-reactive protein (CRP) level has been shown to be associated with survival of patients with various malignancies including localized and ..
  83. Kazumi T, Kawaguchi A, Hirano T, Yoshino G. C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol. Metabolism. 2003;52:1113-6 pubmed
    ..anthropometric, biochemical, and cardiovascular variables are associated with serum levels of C-reactive protein (CRP) in young, apparently healthy men, a cross-sectional study of 179 male college students aged 18 to 22 years was ..
  84. Hoshi T, Kitagawa K, Yamagami H, Furukado S, Hougaku H, Hori M. Relations of serum high-sensitivity C-reactive protein and interleukin-6 levels with silent brain infarction. Stroke. 2005;36:768-72 pubmed
    ..Higher levels of hsCRP and IL-6 appear to be associated with small SBI, suggesting a role of inflammatory processes in cerebral small vessel disease. ..
  85. Jabs W, Theissing E, Nitschke M, Bechtel J, Duchrow M, Mohamed S, et al. Local generation of C-reactive protein in diseased coronary artery venous bypass grafts and normal vascular tissue. Circulation. 2003;108:1428-31 pubmed
    ..In atherosclerotic diseases, serum C-reactive protein (CRP) levels have become an important diagnostic and prognostic marker...
  86. Kathiresan S, Larson M, Vasan R, Guo C, Gona P, Keaney J, et al. Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level. Circulation. 2006;113:1415-23 pubmed
    Serum C-reactive protein (CRP) level is a heritable complex trait that predicts incident cardiovascular disease. We investigated the clinical and genetic sources of interindividual variability in serum CRP...
  87. Naitza S, Porcu E, Steri M, Taub D, Mulas A, Xiao X, et al. A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. PLoS Genet. 2012;8:e1002480 pubmed publisher
    ..53×10(-13)) and in CADM3 (rs3026968, p?=?7.63×10(-13)); for hsCRP, within the CRP gene (rs3093077, p?=?5.73×10(-21)), near DARC (rs3845624, p?=?1.43×10(-10)), UNC119B/SPPL3 (rs11829037, p?=?1...
  88. Mantovani A, Valentino S, Gentile S, Inforzato A, Bottazzi B, Garlanda C. The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules. Ann N Y Acad Sci. 2013;1285:1-14 pubmed publisher
    ..C-reactive protein (CRP) and serum amyloid P component are prototypes of the short pentraxin family, while pentraxin 3 (PTX3) is a ..
  89. Stein M, Edberg J, Kimberly R, Mangan E, Bharadwaj D, Mold C, et al. C-reactive protein binding to FcgammaRIIa on human monocytes and neutrophils is allele-specific. J Clin Invest. 2000;105:369-76 pubmed
    C-reactive protein (CRP) is involved in host defense, regulation of inflammation, and modulation of autoimmune disease...
  90. Dhingra R, Gona P, Nam B, D Agostino R, Wilson P, Benjamin E, et al. C-reactive protein, inflammatory conditions, and cardiovascular disease risk. Am J Med. 2007;120:1054-62 pubmed
    It is uncertain to what extent high C-reactive protein (CRP) concentrations reflect the presence of inflammatory conditions in the community...
  91. Doumatey A, Chen G, Tekola Ayele F, Zhou J, Erdos M, Shriner D, et al. C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans. Hum Mol Genet. 2012;21:3063-72 pubmed publisher
    C-reactive protein (CRP) is an acute phase reactant protein produced primarily by the liver. Circulating CRP levels are influenced by genetic and non-genetic factors, including infection and obesity...
  92. Torzewski M, Reifenberg K, Cheng F, Wiese E, Küpper I, Crain J, et al. No effect of C-reactive protein on early atherosclerosis in LDLR-/- / human C-reactive protein transgenic mice. Thromb Haemost. 2008;99:196-201 pubmed publisher
    The association between increased concentrations of C-reactive protein (CRP) and future cardiovascular events is well established...