CRIP1

Summary

Gene Symbol: CRIP1
Description: cysteine rich protein 1
Alias: CRHP, CRIP, CRP-1, CRP1, cysteine-rich protein 1, cysteine-rich heart protein, cysteine-rich intestinal protein, cysteine-rich protein 1 (intestinal)
Species: human
Products:     CRIP1

Top Publications

  1. Tsui S, Yam N, Lee C, Waye M. Isolation and characterization of a cDNA that codes for a LIM-containing protein which is developmentally regulated in heart. Biochem Biophys Res Commun. 1994;205:497-505 pubmed
    ..We have expressed hCRHP in E. coli using pAED4 as the vector and the cDNA was engineered so that the authentic protein is produced. The protein was partially purified and was shown to be a basic protein. ..
  2. Wang Q, Williamson M, Bott S, Brookman Amissah N, Freeman A, Nariculam J, et al. Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer. Oncogene. 2007;26:6560-5 pubmed
    ..MMTV integration site 5A (WNT5A), S100 calcium-binding protein P (S100P) and cysteine-rich protein 1(CRIP1) was confirmed in the cancer cells by bisulfite sequencing...
  3. Khoo C, Blanchard R, Sullivan V, Cousins R. Human cysteine-rich intestinal protein: cDNA cloning and expression of recombinant protein and identification in human peripheral blood mononuclear cells. Protein Expr Purif. 1997;9:379-87 pubmed
    Cysteine-rich intestinal protein (CRIP) is a small, 8.5-kDa protein with one double zinc-finger motif called a LIM domain...
  4. Zhang L, Zhou R, Zhang W, Yao X, Li W, Xu L, et al. Cysteine-rich intestinal protein 1 suppresses apoptosis and chemosensitivity to 5-fluorouracil in colorectal cancer through ubiquitin-mediated Fas degradation. J Exp Clin Cancer Res. 2019;38:120 pubmed publisher
    Cysteine-rich intestinal protein 1 (CRIP1) is highly expressed in human intestine and aberrantly expressed in several types of tumor...
  5. Samkani A, Skytte M, Anholm C, Astrup A, Deacon C, Holst J, et al. The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial. Lipids Health Dis. 2018;17:295 pubmed publisher
    ..NEFA and TG responses were assessed in subjects with T2DM by comparing a carbohydrate-reduced high-protein (CRHP) diet with a conventional diabetes (CD) diet in an open-label, randomized, cross-over study...
  6. Fukuoka K, Kanemura Y, Shofuda T, Fukushima S, Yamashita S, Narushima D, et al. Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors. Acta Neuropathol Commun. 2018;6:134 pubmed publisher
    ..assay was developed to determine the PFB subgroup with 100% specificity using the methylation status of 3 genes, CRIP1, DRD4 and LBX2...
  7. Shen Y, Cohen J, Nicoloro S, Kelly M, Yenilmez B, Henriques F, et al. CRISPR-delivery particles targeting nuclear receptor-interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure. J Biol Chem. 2018;293:17291-17305 pubmed publisher
    ..Of note, the CriP-mediated Nrip1 deletion did not produce detectable off-target effects...
  8. Samkani A, Skytte M, Thomsen M, Astrup A, Deacon C, Holst J, et al. Acute Effects of Dietary Carbohydrate Restriction on Glycemia, Lipemia and Appetite Regulating Hormones in Normal-Weight to Obese Subjects. Nutrients. 2018;10: pubmed publisher
    ..transition from the recommended moderately high carbohydrate (HC) diet towards a carbohydrate-reduced high-protein (CRHP) diet on postprandial glycemia, insulinemia, lipemia, and appetite-regulating hormones in non-diabetic adults...
  9. Zhang L, Huang L, Huang A, Liu J, Yang F. CRIP1 promotes cell migration, invasion and epithelial-mesenchymal transition of cervical cancer by activating the Wnt/??catenin signaling pathway. Life Sci. 2018;207:420-427 pubmed publisher
    ..Cysteine-rich intestinal protein 1 (CRIP1) is differently expressed in human cancer cells. However, the role it plays in CC has not been revealed at present...

More Information

Publications40

  1. Fujishiro T, Mashiko T, Masuoka Y, Yamada M, Furukawa D, Yazawa N, et al. Conversion surgery for an initially unresectable, locally advanced pancreatic cancer after induction chemotherapy and carbon-ion radiotherapy: a case report. Surg Case Rep. 2018;4:112 pubmed publisher
    ..facility and was subsequently diagnosed with pancreatic cancer cStage III (Ph, TS2 (35 mm), cT4, cCH1, cDU1, cS1, cRP1, cPL1, cVsm0, cAsm1, cN0, cM0) that was also categorized as an unresectable LAPC...
  2. Aung H, Dixon L, Smith L, Sweeney N, Robson J, Berney M, et al. Novel regulatory roles of cAMP receptor proteins in fast-growing environmental mycobacteria. Microbiology. 2015;161:648-61 pubmed publisher
    ..saprophytic, mycobacterial species that contains two cAMP-receptor protein (CRP) homologues designated herein as Crp1 and Crp2...
  3. Miranda J, Cabral J, Wagner S, Fischer Pedersen C, Ravelo B, Memon M, et al. An Open Platform for Seamless Sensor Support in Healthcare for the Internet of Things. Sensors (Basel). 2016;16: pubmed
    ..development, implementation and evaluation of a platform called Common Recognition and Identification Platform (CRIP), a part of the CareStore project, which aims at supporting caregivers and citizens to manage health routines in a ..
  4. Wilkerson A, Fisher J, Fletcher W. Composing Disability: Diagnosis, Interrupted. J Bioeth Inq. 2016;13:473-476 pubmed publisher
    ..Queer" and "crip" interrogations of diagnosis illuminate its status as a cultural phenomenon, embracing culturally disavowed ..
  5. Danylevich T. De-Privatizing Self-Harm: Remembering the Social Self in How to Forget. J Bioeth Inq. 2016;13:507-514 pubmed publisher
    ..and queer theory, psychoanalysis, and sociology of medicine, the author argues that How to Forget charts a "crip" epistemology of self-harm and theorizes a "social self...
  6. Zheng S, Chang W, Li C, Lou H. Als1 and Als3 regulate the intracellular uptake of copper ions when Candida albicans biofilms are exposed to metallic copper surfaces. FEMS Yeast Res. 2016;16: pubmed publisher
    ..Transcriptional analysis revealed that the expression of copper transporter-related gene, CRP1, was significantly increased in als1/als1, als3/als3, suggesting a potential role of ALS1 and ALS3 in absorbing ..
  7. Cai H, Chen J, Liu J, Zeng M, Ming F, Lu Z, et al. CRIP1, a novel immune-related protein, activated by Enterococcus faecalis in porcine gastrointestinal epithelial cells. Gene. 2017;598:84-96 pubmed publisher
    Cysteine-rich intestinal protein 1 (CRIP1) is an important transcriptional regulation factor during the tumor development...
  8. Zaidi M, O Leary S, Wu S, Chabot D, Gleddie S, Laroche A, et al. Investigating Triticeae anther gene promoter activity in transgenic Brachypodium distachyon. Planta. 2017;245:385-396 pubmed publisher
    ..as well as the tapetum-specific genes chalcone synthase-like 1 (CHSL1), from wheat and cysteine-rich protein 1 (CRP1) from triticale were fused to the green fluorescent protein gene (GFP) and analyzed in transgenic Brachypodium...
  9. Mello A. [Disability, inability and vulnerability: on ableism or the pre-eminence of ableist and biomedical approaches of the Human Subjects Ethics Committee of UFSC]. Cien Saude Colet. 2016;21:3265-3276 pubmed publisher
    ..In this ethnographic experience, in the light of Crip theory, I observed how the "disability," "vulnerability" and "inability" categories are articulated to reveal the ..
  10. Larracas C, Hekman R, Dyrness S, Arata A, Williams C, Crawford T, et al. Comprehensive Proteomic Analysis of Spider Dragline Silk from Black Widows: A Recipe to Build Synthetic Silk Fibers. Int J Mol Sci. 2016;17: pubmed publisher
    ..dope, and dragline silk contain at least seven common proteins: three members of the Cysteine-Rich Protein Family (CRP1, CRP2 and CRP4), cysteine-rich secretory protein 3 (CRISP3), fasciclin and two uncharacterized proteins...
  11. Hempel A, Kühl S. Comparative expression analysis of cysteine-rich intestinal protein family members crip1, 2 and 3 during Xenopus laevis embryogenesis. Int J Dev Biol. 2014;58:841-9 pubmed publisher
    ..study, we have described for the first time the spatio-temporal expression pattern of the three family members crip1, crip2 and crip3 during Xenopus laevis embryogenesis by RT-PCR and whole mount in situ hybridization approaches...
  12. Ghamrawi S, Gastebois A, Zykwinska A, Vandeputte P, Marot A, Mabilleau G, et al. A Multifaceted Study of Scedosporium boydii Cell Wall Changes during Germination and Identification of GPI-Anchored Proteins. PLoS ONE. 2015;10:e0128680 pubmed publisher
    ..The identified sequences belonged to protein families involved in virulence in other fungi like Gelp/Gasp, Crhp, Bglp/Bgtp families and a superoxide dismutase...
  13. Wang W, Liu Y, Hao J, Zheng S, Wen Y, Xiao X, et al. Comparative analysis of gene expression profiles of hip articular cartilage between non-traumatic necrosis and osteoarthritis. Gene. 2016;591:43-47 pubmed publisher
    ..of NOFH cartilage and OA cartilage detected 8 common differently expressed genes, including COL5A1, OGN, ANGPTL4, CRIP1, NFIL3, METRNL, ID2 and STEAP1...
  14. Eriguchi Y, Nakamura K, Hashimoto D, Shimoda S, Shimono N, Akashi K, et al. Decreased secretion of Paneth cell α-defensins in graft-versus-host disease. Transpl Infect Dis. 2015;17:702-6 pubmed publisher
    ..We directly measured α-defensin cryptdin-1 (Crp1) in fecal pellets of mice with GVHD by using a novel enzyme-linked immunosorbent assay...
  15. Straubinger J, Boldt K, Kuret A, Deng L, Krattenmacher D, Bork N, et al. Amplified pathogenic actions of angiotensin II in cysteine-rich LIM-only protein 4-negative mouse hearts. FASEB J. 2017;31:1620-1638 pubmed publisher
    ..intestinal protein (CRIP)1 in murine hearts lacking CRP4, as well as severe cardiac defects and premature death of CRIP1 and CRP4 morphant zebrafish embryos, further support the notion that depleting CRP4 is incompatible with a proper ..
  16. Ferrari R, Tadini L, Moratti F, Lehniger M, Costa A, Rossi F, et al. CRP1 Protein: (dis)similarities between Arabidopsis thaliana and Zea mays. Front Plant Sci. 2017;8:163 pubmed publisher
    ..of chloroplast biogenesis by At5g42310, a member of the Arabidopsis PPR family which we here refer to as AtCRP1 (Chloroplast RNA Processing 1), providing a comparison with the orthologous ZmCRP1 protein from Zea mays
  17. Dube J, Chapdelaine P, Trahan P, Deperthes D, Frenette G, Tremblay R. Abundant cysteine-rich protein-1 is localized in the stromal compartment of the human prostate. Arch Androl. 1998;40:109-15 pubmed
    The cysteine-rich protein-1 (CRP1) is one of the major proteins of the human prostate...
  18. He G, Zou L, Zhou L, Gao P, Qian X, Cui J. Cysteine-Rich Intestinal Protein 1 Silencing Inhibits Migration and Invasion in Human Colorectal Cancer. Cell Physiol Biochem. 2017;44:897-906 pubmed publisher
    Cysteine-rich intestinal protein 1 (CRIP1), a member of the LIM/double zinc finger protein family, is abnormally expressed in several tumour types. However, few data are available on the role of CRIP1 in cancer...
  19. Jung H, Kim D, Nam S, Kim J, Chung J, Won M, et al. Pyridoxine improves hippocampal cognitive function via increases of serotonin turnover and tyrosine hydroxylase, and its association with CB1 cannabinoid receptor-interacting protein and the CB1 cannabinoid receptor pathway. Biochim Biophys Acta Gen Subj. 2017;1861:3142-3153 pubmed publisher
    ..Phosphoglycerate mutase 1 was up-regulated, while CB1 cannabinoid receptor-interacting protein 1 (CRIP1) was down-regulated, in the pyridoxine-treated group...
  20. Latonen L, Järvinen P, Suomela S, Moore H, Saarialho Kere U, Laiho M. Ultraviolet B radiation regulates cysteine-rich protein 1 in human keratinocytes. Photodermatol Photoimmunol Photomed. 2010;26:70-7 pubmed publisher
    Cysteine-rich protein 1 (CRP1) is a growth-inhibitory cytoskeletal protein that is induced by ultraviolet (UV) C radiation radiation in fibroblasts...
  21. Khoo C, Cousins R. Purification and properties of rat cysteine-rich intestinal protein. Biochem J. 1994;299 ( Pt 2):445-50 pubmed
    Cysteine-rich intestinal protein (CRIP) is a zinc-binding protein where the binding domain is in the so-called LIM double zinc finger motif. Methods are described for the preparation of CRIP from rat small intestine...
  22. Garcia Barcelo M, Tsui S, Chim S, Fung K, Lee C, Waye M. Mapping of the human cysteine-rich intestinal protein gene CRIP1 to the human chromosomal segment 7q11.23. Genomics. 1998;47:419-22 pubmed
    ..By somatic cell hybrid analysis and radiation hybrid mapping, we have located the gene CRIP1 (HGMW-approved symbol) on the subcentromeric region of the q arm of human chromosome 7, flanking a deletion ..
  23. Li H, Zhao L, Zhang Z, Liu J, Ren K, Li S, et al. The Impact of Cysteine-Rich Intestinal Protein 1 (CRIP1) on Thyroid Carcinoma. Cell Physiol Biochem. 2017;43:2037-2046 pubmed publisher
    b>CRIP1 (cysteine-rich intestinal protein 1) has been found in several tumor types; however, its prognostic impact and role in cellular processes, particularly in thyroid carcinoma, are still unclear...
  24. Hao J, Serohijos A, Newton G, Tassone G, Wang Z, Sgroi D, et al. Identification and rational redesign of peptide ligands to CRIP1, a novel biomarker for cancers. PLoS Comput Biol. 2008;4:e1000138 pubmed publisher
    Cysteine-rich intestinal protein 1 (CRIP1) has been identified as a novel marker for early detection of cancers...
  25. Hempe J, Cousins R. Cysteine-rich intestinal protein binds zinc during transmucosal zinc transport. Proc Natl Acad Sci U S A. 1991;88:9671-4 pubmed
  26. Zeller T, Schurmann C, Schramm K, Muller C, Kwon S, Wild P, et al. Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure. Hypertension. 2017;70:743-750 pubmed publisher
    ..Eight transcripts (CRIP1, MYADM, TIPARP, TSC22D3, CEBPA, F12, LMNA, and TPPP3) were ..
  27. Bello Perez M, Falco A, Medina Gali R, Pereiro P, Encinar J, Novoa B, et al. Neutralization of viral infectivity by zebrafish c-reactive protein isoforms. Mol Immunol. 2017;91:145-155 pubmed publisher
    This work explores the unexpected in vivo and in vitro anti-viral functions of the seven c-reactive protein (crp1-7) genes of zebrafish (Danio rerio)...
  28. Bin P, Liu S, Chen S, Zeng Z, Huang R, Yin Y, et al. The effect of aspartate supplementation on the microbial composition and innate immunity on mice. Amino Acids. 2017;49:2045-2051 pubmed publisher
    ..5 and 1.0% Asp-supplemented groups. Dietary supplementation with 2.0% Asp enhanced the expression of pIgR and Crp1 as compared to the other three groups. The results indicated that dietary 1...
  29. Lambropoulou M, Deftereou T, Kynigopoulos S, Patsias A, Anagnostopoulos C, Alexiadis G, et al. Co-expression of galectin-3 and CRIP-1 in endometrial cancer: prognostic value and patient survival. Med Oncol. 2016;33:8 pubmed publisher
    Endometrial cancer is the sixth most common cancer in women. Galectin-3 (GAL-3) and CRIP-1 are multifunctional proteins which seem to be involved in many neoplasias...
  30. Baumhoer D, Elsner M, Smida J, Zillmer S, Rauser S, Schoene C, et al. CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patients. Oncotarget. 2011;2:970-5 pubmed
    ..In search of new and reliable biomarkers we recently identified cysteine-rich intestinal protein 1 (CRIP1) to have significant prognostic impact in gastric cancer and therefore decided to investigate its role also in ..
  31. Chen B, Young J, Leng F. DNA bending by the mammalian high-mobility group protein AT hook 2. Biochemistry. 2010;49:1590-5 pubmed publisher
    ..The DNA bending angles were estimated to be 34.2 degrees , 33.5 degrees , and 35.4 degrees , respectively. ..