CRHR2

Summary

Gene Symbol: CRHR2
Description: corticotropin releasing hormone receptor 2
Alias: CRF-RB, CRF2, CRFR2, HM-CRF, CRF2 receptor, beta isoform, CRH-R2, corticotropin-releasing factor receptor 2
Species: human

Top Publications

  1. ncbi Localization of the human CRF2 receptor to 7p21-p15 by radiation hybrid mapping and FISH analysis
    A H Meyer
    Sandoz Pharma Ltd, Basel, Switzerland
    Genomics 40:189-90. 1997
  2. pmc Leptin responsiveness of mice deficient in corticotrophin-releasing hormone receptor type 2
    Ruth B S Harris
    Department of Foods and Nutrition, University of Georgia, Athens, GA 30912, USA
    Neuroendocrinology 92:198-206. 2010
  3. pmc A corticotropin-releasing factor system expressed in the cochlea modulates hearing sensitivity and protects against noise-induced hearing loss
    Christine E Graham
    Tufts University School of Medicine, Department of Neuroscience, Boston, MA 02111, USA
    Neurobiol Dis 38:246-58. 2010
  4. doi Urocortin II induces nitric oxide production through cAMP and Ca2+ related pathways in endothelial cells
    Elena Grossini
    Laboratorio di Fisiologia, Dipartimento di Medicina Clinica e Sperimentale, Facolta di Medicina e Chirurgia, Universita del Piemonte Orientale A Avogadro, Novara, Italy
    Cell Physiol Biochem 23:87-96. 2009
  5. ncbi Involvement of corticotropin-releasing factor receptor 2 beta in differentiation of dopaminergic MN9D cells
    Tae Eun Jin
    Department of Physiology, Sungkyunkwan University, School of Medicine and Center For Molecular Medicine, Samsung Biomedical Research Institute, Suwon 440 746, Korea
    Mol Cells 26:243-9. 2008
  6. doi Differential regulation of glucose transporters mediated by CRH receptor type 1 and type 2 in human placental trophoblasts
    Lu Gao
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China
    Endocrinology 153:1464-71. 2012
  7. ncbi Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts
    Lu Gao
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    Endocrinology 148:3645-54. 2007
  8. ncbi Expression of corticotropin-releasing hormone receptor type 1 and type 2 in human pregnant myometrium
    Dan Jin
    Department of Obstetrics and Gynecology, Changhai Hospital, Shanghai, PR China
    Reprod Sci 14:568-77. 2007
  9. doi Differential regulation of prostaglandin production mediated by corticotropin-releasing hormone receptor type 1 and type 2 in cultured human placental trophoblasts
    Lu Gao
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    Endocrinology 149:2866-76. 2008
  10. ncbi Corticotropin-releasing factor (CRF) receptor type 2 in the human stomach: protective biological role by inhibition of apoptosis
    Ekaterini Chatzaki
    Laboratory of Pharmacology, Democritus University of Thrace, Dragana, Alexandroupolis 68100, Greece
    J Cell Physiol 209:905-11. 2006

Detail Information

Publications143 found, 100 shown here

  1. ncbi Localization of the human CRF2 receptor to 7p21-p15 by radiation hybrid mapping and FISH analysis
    A H Meyer
    Sandoz Pharma Ltd, Basel, Switzerland
    Genomics 40:189-90. 1997
  2. pmc Leptin responsiveness of mice deficient in corticotrophin-releasing hormone receptor type 2
    Ruth B S Harris
    Department of Foods and Nutrition, University of Georgia, Athens, GA 30912, USA
    Neuroendocrinology 92:198-206. 2010
    ..increases CRH mRNA expression in the paraventricular nucleus of the hypothalamus and CRH receptor type 2 (CRHR2) expression in the ventromedial nucleus of the hypothalamus...
  3. pmc A corticotropin-releasing factor system expressed in the cochlea modulates hearing sensitivity and protects against noise-induced hearing loss
    Christine E Graham
    Tufts University School of Medicine, Department of Neuroscience, Boston, MA 02111, USA
    Neurobiol Dis 38:246-58. 2010
    ..We demonstrate that mice lacking the CRF receptor CRFR2 exhibit a significantly lower auditory threshold than wild type mice, but this gain of function comes at the price ..
  4. doi Urocortin II induces nitric oxide production through cAMP and Ca2+ related pathways in endothelial cells
    Elena Grossini
    Laboratorio di Fisiologia, Dipartimento di Medicina Clinica e Sperimentale, Facolta di Medicina e Chirurgia, Universita del Piemonte Orientale A Avogadro, Novara, Italy
    Cell Physiol Biochem 23:87-96. 2009
    ..nitric oxide synthase (eNOS) pathway and involvement of the subtype 2 of corticotropin releasing factor receptors (CRFR2)...
  5. ncbi Involvement of corticotropin-releasing factor receptor 2 beta in differentiation of dopaminergic MN9D cells
    Tae Eun Jin
    Department of Physiology, Sungkyunkwan University, School of Medicine and Center For Molecular Medicine, Samsung Biomedical Research Institute, Suwon 440 746, Korea
    Mol Cells 26:243-9. 2008
    ..To validate this statement, we made a CRF receptor 2beta-overexpressing MN9D/CRFR2 beta stable cell line...
  6. doi Differential regulation of glucose transporters mediated by CRH receptor type 1 and type 2 in human placental trophoblasts
    Lu Gao
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China
    Endocrinology 153:1464-71. 2012
    ..Our data suggest that, in placenta, CRH produced locally regulates GLUT1 and GLUT3 expression, CRHR1 and CRHR2-mediated differential regulation of GLUT1 and GLUT3 expression...
  7. ncbi Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts
    Lu Gao
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    Endocrinology 148:3645-54. 2007
    ..We found that both CRHR1 and CRHR2 were localized in cultured chorion trophoblast cells, with CRH-R1alpha, R1beta, R1c, R1e, and R1f and CRHR2beta ..
  8. ncbi Expression of corticotropin-releasing hormone receptor type 1 and type 2 in human pregnant myometrium
    Dan Jin
    Department of Obstetrics and Gynecology, Changhai Hospital, Shanghai, PR China
    Reprod Sci 14:568-77. 2007
    ..A heterogeneous distribution of CRH-R1 variants in term labor and nonlabor myometrium might be related to the effects of CRH on contractile phenotype of myometrium at the term...
  9. doi Differential regulation of prostaglandin production mediated by corticotropin-releasing hormone receptor type 1 and type 2 in cultured human placental trophoblasts
    Lu Gao
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    Endocrinology 149:2866-76. 2008
    ....
  10. ncbi Corticotropin-releasing factor (CRF) receptor type 2 in the human stomach: protective biological role by inhibition of apoptosis
    Ekaterini Chatzaki
    Laboratory of Pharmacology, Democritus University of Thrace, Dragana, Alexandroupolis 68100, Greece
    J Cell Physiol 209:905-11. 2006
    ..Paracrine effects exerted by locally expressed endogenous ligands, such as Ucn I, support a significant role of the peripheral CRF system in gastric physiology. J. Cell. Physiol. 209: 905-911, 2006. (c) 2006 Wiley-Liss, Inc...
  11. ncbi Corticotropin-releasing hormone receptor (CRHR)1 and CRHR2 are both trafficking and signaling receptors for urocortin
    Hong Tu
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Mol Endocrinol 21:700-11. 2007
    ..CRHR1-mediated urocortin endocytosis was blocked by astressin (antagonist for both CRHRs), whereas CRHR2-mediated urocortin endocytosis was also blocked by antisauvagine 30 (selective CRHR2beta antagonist)...
  12. ncbi Cloning and characterization of human urocortin
    C J Donaldson
    Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla 92037, USA
    Endocrinology 137:2167-70. 1996
    ..The inhibitory effect of the CRF-binding protein on human urocortin can be blocked by biologically inactive CRF fragments, such as CRF(9-33)...
  13. ncbi Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term
    B Wetzka
    Dept of Obstetrics and Gynecology, University of Freiburg, Freiburg, Germany
    Exp Clin Endocrinol Diabetes 111:154-61. 2003
    ..This widespread expression of the CRH system in gestational tissue suggests a paracrine role for CRH in the birth process (e.g. effects on macrophages and endothelial cells)...
  14. doi Urocortin's inhibition of tumor growth and angiogenesis in hepatocellular carcinoma via corticotrophin-releasing factor receptor 2
    Juejin Wang
    Department of Pharmacology, Nanjing Medical University, Nanjing, China
    Cancer Invest 26:359-68. 2008
    Urocortin (UCN) functions via corticotrophin-releasing factor receptors (CRFRs), CRFR1 & 2. CRFR2 is reported to be a tonic suppressor of vascularization, implying its role in tumor angiogenesis...
  15. doi The involvement of altered corticotropin releasing factor receptor 2 expression in prostate cancer due to alteration of anti-angiogenic signaling pathways
    Hossein Tezval
    Department of Urology and Urological Oncology, Hannover Medical School, Germany
    Prostate 69:443-8. 2009
    ..Ucn binds and activates corticotropin releasing factor (CRF) receptor 1 (CRFR1) and 2 (CRFR2)...
  16. ncbi Impact of maternal deprivation on brain corticotropin-releasing hormone circuits: prevention of CRH receptor-2 mRNA changes by desipramine treatment
    Delia M Vazquez
    Department of Pediatrics, Endocrine Division, University of Michigan, 1150 West Medical Center Drive, 8346 Medical Science Research Building III, Ann Arbor, MI 48109 0646, USA
    Neuropsychopharmacology 28:898-909. 2003
    ..In amygdala, CRHr1 and r2 mRNAs were decreased. CRHr2 mRNA was also decreased in the ventromedial nucleus of the hypothalamus, whereas an increase was detected in the ..
  17. pmc Urocortin II mediates pro-inflammatory effects in human colonocytes via corticotropin-releasing hormone receptor 2alpha
    Alan C Moss
    Gastrointestinal Neuropeptide Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Gut 56:1210-7. 2007
    ..II (UcnII) is a neuropeptide that binds with high affinity to the corticotropin-releasing hormone receptor 2 (CRHR2) in peripheral tissues...
  18. pmc Corticotropin-releasing hormone receptor expression and functional signaling in murine gonadotrope-like cells
    Audrey F Seasholtz
    Molecular and Behavioral Neuroscience Institute, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109, USA
    J Endocrinol 200:223-32. 2009
    ..PCR (RT-PCR) studies demonstrated that alpha T3-1 cells express mRNA for the two CRH receptor subtypes, CRHR1 and CRHR2, with CRHR2alpha as the predominant CRHR2 isoform...
  19. ncbi Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I
    Ward A Pedersen
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Neurosci 22:404-12. 2002
    ..G-protein-coupled receptors have been identified that bind CRH and/or urocortin I and II, designated CRHR1 and CRHR2, both of which are present in hippocampal regions of mammalian brain...
  20. ncbi Type 1 corticotropin-releasing factor receptors in the ventromedial hypothalamus promote hypoglycemia-induced hormonal counterregulation
    Haiying Cheng
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Endocrinol Metab 293:E705-12. 2007
    Type 2 corticotropin-releasing factor (CRF) receptors (CRFR2) within the ventromedial hypothalamus (VMH), a key glucose-sensing region, play a major role in regulating the hormonal counterregulatory responses (CRRs) to acute hypoglycemia...
  21. doi Involvement of CRH receptors in urocortin-induced hyperthermia
    G Telegdy
    Department of Pathophysiology, University of Szeged, Semmelweis 1, Szeged 6701, Hungary
    Peptides 29:1937-42. 2008
    The actions of individual corticotropin-releasing hormone (CRH) receptor (CRHR1 and CRHR2) were studied on the hyperthermia caused by urocortin 1, urocortin 2 and urocortin 3 in rats...
  22. ncbi Mouse corticotropin-releasing factor receptor type 2alpha gene: isolation, distribution, pharmacological characterization and regulation by stress and glucocorticoids
    Alon Chen
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Mol Endocrinol 19:441-58. 2005
    ..factor (CRF) family of peptides are mediated through activation of two receptors, CRF receptor (CRFR) 1 and CRFR2. Based on the homology between known mammalian CRFR genes, we have isolated a cDNA encoding the mouse CRFR2alpha (..
  23. ncbi Urocortin-II and urocortin-III are cardioprotective against ischemia reperfusion injury: an essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine heart
    Bhawanjit K Brar
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    Endocrinology 145:24-35; discussion 21-3. 2004
    ..001). The CRFR2 selective antagonist astressin2-B and an ERK1/2-p42, 44 inhibitor abolish the cardioprotective actions of Ucn-II ..
  24. ncbi Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1
    A Contarino
    The Scripps Research Institute, Department of Neuropharmacology, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Brain Res 835:1-9. 1999
    ..Two distinct CRF receptor subtypes, CRFR1 and CRFR2, are thought to mediate CRF actions in the CNS...
  25. ncbi Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development
    G W Smith
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    Neuron 20:1093-102. 1998
    ..Two biochemically and pharmacologically distinct CRF receptor subtypes (CRFR1 and CRFR2) have been described...
  26. ncbi Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes
    A Chanalaris
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    J Mol Cell Cardiol 35:1295-305. 2003
    ..is able to bind to two types of G-protein coupled receptors: CRF receptor type 1 (CRFR1) and CRF receptor type 2 (CRFR2), whereas, two homologues of UCN, stresscopin (SCP) or also known as urocortin III (UCNIII) and stresscopin ..
  27. doi Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC epsilon pathway
    Jin Tao
    Department of Neurobiology, Laboratory of Aging and Nervous Diseases, Medical College of Soochow University, Suzhou, PR China
    Cell Signal 21:1436-43. 2009
    ..investigated the expression profile of CRF receptors in rat cerebellum and identified a novel functional role of CRFR2 in modulating Purkinje neuron P-type Ca(2+) currents (P-currents)...
  28. doi Differential stress-induced alterations of colonic corticotropin-releasing factor receptors in the Wistar Kyoto rat
    D O'Malley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Neurogastroenterol Motil 22:301-11. 2010
    ..KEY RESULTS No intra-strain differences were observed in the numbers of colonic CRFR1 and CRFR2 positive cells...
  29. ncbi Corticotropin-releasing factor receptor type 1, but not type 2, in the ventromedial hypothalamus modulates dopamine release in female rats
    Tomohiro Muramatsu
    Department of Neuropsychiatry, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka City, Osaka 545 8585, Japan
    Pharmacol Biochem Behav 85:435-40. 2006
    ..responses and is mediated through two subtypes of receptors, CRF receptor type 1 (CRFR1) and CRF receptor type 2 (CRFR2)...
  30. pmc A soluble mouse brain splice variant of type 2alpha corticotropin-releasing factor (CRF) receptor binds ligands and modulates their activity
    Alon M Chen
    Clayton Foundation Laboratories for Peptide Biology and Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:2620-5. 2005
    ..factor (CRF) family signal through the activation of two receptors, CRF receptor type 1 (CRFR1) and type 2 (CRFR2), both of which exist as multiple splice variants...
  31. pmc Differentiation dependent expression of urocortin's mRNA and peptide in human osteoprogenitor cells: influence of BMP-2, TGF-beta-1 and dexamethasone
    Mohammad Tezval
    Department of Trauma, Plastic and Reconstructive Surgery, Goettingen University Hospital, University Medicine Goetingen, Robert Koch Str 40, 37075 Goettingen, Germany
    J Mol Histol 40:331-41. 2009
    ..of UCN are mediated via stimulation of CRF-receptors 1 and 2 (CRFR1 and 2, CRFR's) with a high affinity for CRFR2. It has been shown that the CRF-related peptides and CRFR's are involved in the regulation of stress-related ..
  32. ncbi Corticotropin-releasing hormone (CRH) depresses n-methyl-D-aspartate receptor-mediated current in cultured rat hippocampal neurons via CRH receptor type 1
    Hui Sheng
    Department of Physiology, Ministry of Education, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    Endocrinology 149:1389-98. 2008
    ..This effect was reversed by the CRH receptor type 1 (CRHR1) antagonist antalarmin but not by the CRHR2 antagonist astressin-2B, suggesting that CRHR1 mediated the inhibitory effect of CRH...
  33. pmc Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas
    Damian Refojo
    Departamento Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Laboratorio de Fisiologia y Biologia Molecular, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
    Proc Natl Acad Sci U S A 102:6183-8. 2005
    ..To dissect the involvement of CRH receptor 1 (CRHR1) and CRHR2, we used conditional knockout mice in which Crhr1 is inactivated in the anterior forebrain and limbic structures...
  34. pmc Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2α in MIN6 insulinoma cells and rodent islets
    M O Huising
    The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Endocrinology 152:138-50. 2011
    ..Ucn 3 activates the CRF type-2 receptor (CRFR2) but does not activate the type-1 receptor (CRFR1), which was recently demonstrated on β-cells...
  35. doi Regulatory mechanism of hypothalamo-pituitary-adrenal (HPA) axis and neuronal changes after adrenalectomy in type 2 diabetes
    Sun Shin Yi
    Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 151 742, South Korea
    J Chem Neuroanat 40:130-9. 2010
    ..Additionally, mRNA expression of AVP and CRH receptors (V1aR, V1bR, CRHR1, and CRHR2) was also measured and adrenocorticotropin hormone (ACTH) immunoreactivity was surveyed by IHC to add to data ..
  36. doi Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling
    K Kamprath
    Max Planck Institute of Psychiatry, Munich, Germany
    Genes Brain Behav 8:203-11. 2009
    ..blockade of CB(1) receptors by rimonabant in mice deficient for the CRH receptor type 1 (CRHR1(-/-)) or type 2 (CRHR2(-/-)), and in respective wild-type littermates, resulted in a sustained fear response in all genotypes...
  37. pmc Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor
    Kuntal Pal
    Laboratory of Structural Sciences, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    J Biol Chem 285:40351-61. 2010
    ..and cardiovascular function by activating either of two related class B G protein-coupled receptors, CRFR1 and CRFR2. CRF and Ucn1 activate both receptors, whereas Ucn2 and Ucn3 are CRFR2-selective...
  38. ncbi [Role of corticotropin releasing factor receptor 2 antisense oligodeoxynucleotide of hypothalamus in hypermetabolism in rats with severe burn]
    Zhong yong Chen
    Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, The Third Military Medical University, Chongqing 400038, PR China
    Zhonghua Shao Shang Za Zhi 24:414-7. 2008
    To observe the role of corticotropin releasing factor receptor 2 antisense oligodeoxynucleotide (CRFR2ASO) of hypothalamus in hypermetabolism in rats with severe burn.
  39. pmc Urocortin 2 expression in the rat gastrointestinal tract under basal conditions and in chemical colitis
    Jen Chang
    Department of Surgery, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Peptides 28:1453-60. 2007
    ..a large population of immune cells that infiltrated the lamina propria and submucosa of the distal colon, whereas CRFR2-IR was detected in only a small fraction of infiltrated immune cells...
  40. pmc Central nervous system-specific knockout of steroidogenic factor 1 results in increased anxiety-like behavior
    Liping Zhao
    University of Texas Southwestern, Dallas, Texas 75390 8857, USA
    Mol Endocrinol 22:1403-15. 2008
    ..to stress and anxiety-like behavior, including brain-derived neurotrophic factor, the type 2 receptor for CRH (Crhr2), and Ucn 3. Moreover, transfection and EMSAs support a direct role of SF-1 in Crhr2 regulation...
  41. ncbi Stress-mediated heart rate dynamics after deletion of the gene encoding corticotropin-releasing factor receptor 2
    Oliver Stiedl
    Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, D 37075 Goettingen, Germany
    Eur J Neurosci 17:2231-5. 2003
    ..of the present study was to investigate the potential role of corticotropin-releasing factor receptor subtype 2 (CRFR2) in autonomic regulation of heart rate and heart rate variability under physiological conditions in conscious mice...
  42. doi Gestational hypoxia alone or combined with restraint sensitizes the hypothalamic-pituitary-adrenal axis and induces anxiety-like behavior in adult male rat offspring
    J M Fan
    Division of Neurobiology and Physiology, College of Life Sciences, School of Medicine, Zhejiang University, Hangzhou, China
    Neuroscience 159:1363-73. 2009
    ..factor receptor type 1 (CRHR1) expression but decreased corticotropin-releasing factor receptor type 2 (CRHR2) in the paraventricular nucleus of the hypothalamus (PVN), enhanced CRHR1 mRNA and CRHR2 mRNA expression in the ..
  43. ncbi A new role for corticotropin-releasing factor receptor-2: suppression of vascularization
    Tracy L Bale
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Cardiovasc Med 13:68-71. 2003
    ..Our recent data has described a novel role of corticotropin-releasing factor receptor-2 (CRFR2) as a tonic inhibitor of neovascularization...
  44. pmc Vital functions of corticotropin-releasing factor (CRF) pathways in maintenance and regulation of energy homeostasis
    Kendall M Carlin
    Department of Animal Biology, University of Pennsylvania, Philadelphia, 19104, USA
    Proc Natl Acad Sci U S A 103:3462-7. 2006
    ..A major determinate of these responses is corticotropin-releasing factor (CRF). Receptors for CRF, CRFR1 and CRFR2, have been hypothesized to play distinct roles in the alterations necessary for homeostatic maintenance...
  45. ncbi Regulation of corticotropin-releasing hormone type 2 receptors by multiple promoters and alternative splicing: identification of multiple splice variants
    Rob D Catalano
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom
    Mol Endocrinol 17:395-410. 2003
    We demonstrate that multiple promoters and alternate splicing regulate expression of the human CRH receptor type 2 (CRHR2) gene...
  46. ncbi Neuropeptide urocortin and its receptors are expressed in rat Kupffer cells
    Ioannis Charalampopoulos
    Department of Pharmacology, School of Medicine, University of Crete, Heraklion, Greece
    Neuroendocrinology 84:49-57. 2006
    ..Our findings are as follows: (1) In highly purified KCs the transcripts of UCN, of its receptors CRHR1, CRHR2 and that of the pseudoreceptor CRH-binding protein (CRHBP) were present while that of CRH was not detectable...
  47. doi Development of alopecia areata is associated with higher central and peripheral hypothalamic-pituitary-adrenal tone in the skin graft induced C3H/HeJ mouse model
    Xingqi Zhang
    Department of Dermatology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, People s Republic of China
    J Invest Dermatol 129:1527-38. 2009
    ..Nr3c1), mineralocorticoid receptor (Nr3c2), corticotropin-releasing hormone receptor types 1 and 2 (Crhr1, Crhr2), interleukin-12 (Il12), tumor necrosis factor-alpha (Tnf alpha), and estrogen receptors type-1 (Esr1) and type-2 (..
  48. ncbi Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment
    Sergi Papiol
    Unitat d Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    J Affect Disord 104:83-90. 2007
    ..Our aim was to investigate the influence of genetic variants in CRHR1, CRHR2, CRH-BP and FKBP5 genes on both the vulnerability for depression and the response to antidepressant treatment.
  49. ncbi Expression of urocortin 2 and its inhibitory effects on intracellular ca2+ via L-type voltage-gated calcium channels in rat pheochromocytoma (PC12) cells
    Jin Tao
    Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing, PR China
    Neuropsychopharmacology 31:2600-9. 2006
    ..effects of urocortin 2 on VGCC currents or [Ca(2+)](i) were not affected by astressin 2B, an antagonist of CRFR2. As calcium overload play a key role in some neuronal degenerative diseases such as Alzheimer's and Parkinson's ..
  50. ncbi Expression of CRHR1 and CRHR2 in mouse pituitary and adrenal gland: implications for HPA system regulation
    M B Müller
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Endocrinology 142:4150-3. 2001
    ..by means of RT-PCR and in situ hybridization analyses, we could provide first evidence that both CRHR1 and CRHR2 are expressed in the mouse pituitary and adrenal cortex...
  51. pmc Antagonism of corticotrophin-releasing factor receptors in the fourth ventricle modifies responses to mild but not restraint stress
    Joanna R Miragaya
    Department of Foods and Nutrition, Dawson Hall, University of Georgia, Athens, GA 30602, USA
    Am J Physiol Regul Integr Comp Physiol 295:R404-16. 2008
    ..MS rats infused with 3 nmol antisauvagine-30, a CRFR2 antagonist, did not lose weight in the 48 h after MS, but 0.3 nmol did not prevent weight loss in MS rats...
  52. ncbi Perfluorooctane sulfonate influences feeding behavior and gut motility via the hypothalamus
    Akihiro Asakawa
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Int J Mol Med 19:733-9. 2007
    ..A centrally administered corticotropin-releasing factor type 2 receptor (CRFR2) antagonist blocked PFOS-induced anorexia. These findings indicate that PFOS and PFOA influence feeding behavior...
  53. pmc Antagonism of specific corticotropin-releasing factor receptor subtypes selectively modifies weight loss in restrained rats
    Christina Chotiwat
    Department of Foods and Nutrition, University of Georgia, Dawson Hall, Athens, GA 30605, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1762-73. 2008
    ..Third-ventricle administration of a CRFR2 antagonist, antisauvagine 30, had no effect in RRS rats but caused sustained weight loss in control animals...
  54. pmc Early weaning stress impairs development of mucosal barrier function in the porcine intestine
    Feli Smith
    Department of Population Health and Pathobiology, North Carolina State University, Raleigh, 27606, USA
    Am J Physiol Gastrointest Liver Physiol 298:G352-63. 2010
    ..pigs revealed that CRF receptor 1 (CRFr1) activation mediates barrier dysfunction and hypersecretion, whereas CRFr2 activation may be responsible for novel protective properties in the porcine intestine in response to early life ..
  55. doi Compulsivity in mouse strains homologous with chromosomes 7p and 15q linked to obsessive-compulsive disorder
    Martien J H Kas
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 153:252-9. 2010
    ..In the overlapping (human/mouse) genomic region, the CRH receptor 2 (CRHR2) gene was tested in a human case-control study...
  56. ncbi The effects of corticoptropin-releasing factor and the urocortins on striatal dopamine release induced by electrical stimulation-an in vitro superfusion study
    Zsolt Bagosi
    Department of Pathophysiology, University of Szeged, Semmelweis u 1, PO Box 427, H 6725 Szeged, Hungary
    Neurochem Res 31:209-13. 2006
    ..The CRFR2 antagonist astressin-2B was ineffective...
  57. ncbi Urocortin in the lateral septal area modulates feeding induced by orexin A in the lateral hypothalamus
    Chuanfeng Wang
    Veterans Affairs Medical Center, Geriatric, Research, Education and Clinical Center and Research Service, Minneapolis 55417, USA
    Am J Physiol Regul Integr Comp Physiol 283:R358-67. 2002
    ..LSi) contains high levels of urocortin (UCN) peptide and type 2 corticotropin-releasing hormone (CRH) receptor (CRHR2) and has anatomic and functional connections with the lateral hypothalamus (LH)...
  58. pmc Urocortin protects chondrocytes from NO-induced apoptosis: a future therapy for osteoarthritis?
    N Y Intekhab-Alam
    Department of Biomedical Sciences, School of Life Sciences, University of Westminster, London, UK
    Cell Death Dis 4:e717. 2013
    ..with subsequent amplicon sequence analysis and demonstrates that C-20/A4 cells express both CRFR1 and CRFR2, specifically CRFR1α and CRFR2β. Protein expression of these receptors was confirmed by western blotting...
  59. pmc Urocortin 2 autocrine/paracrine and pharmacologic effects to activate AMP-activated protein kinase in the heart
    Ji Li
    Department of Pharmacology and Toxicology, University at Buffalo, The State University of New York, Buffalo, NY 14214
    Proc Natl Acad Sci U S A 110:16133-8. 2013
    ..a peptide of the corticotropin-releasing factor (CRF) family, binds with high affinity to type 2 CRF receptors (CRFR2) on cardiomyocytes and confers protection against ischemia/reperfusion...
  60. pmc Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive
    Julia C Lemos
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195, USA
    Nature 490:402-6. 2012
    ..the nucleus accumbens of naive mice to increase dopamine release through coactivation of the receptors CRFR1 and CRFR2. Remarkably, severe-stress exposure completely abolished this effect without recovery for at least 90 days...
  61. doi Estrogens protect myocardium against ischemia/reperfusion insult by up-regulation of CRH receptor type 2 in female rats
    Binhai Cong
    Department of Physiology and The Key Laboratory of Molecular Neurobiology of Ministry of Education, Second Military Medical University, Shanghai 200433, PR China
    Int J Cardiol 168:4755-60. 2013
    ..The goal of present study is to investigate whether estrogens regulate UCN and its receptor CRH receptor type 2 (CRHR2) in female rat heart.
  62. doi Urocortin increased endothelial ICAM1 by cPLA2-dependent NF-κB and PKA pathways in HUVECs
    Rong Wan
    Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, People s Republic of China The Key Laboratory of Molecular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, People s Republic of China
    J Mol Endocrinol 52:43-53. 2014
    ..that Ucn1 increased ICAM1 and cyclooxygenase 2 (COX2) expressions in a time-dependent manner via CRH receptor 2 (CRHR2). In addition, COX2 was involved in ICAM1 upregulation...
  63. doi Overexpression of corticotropin-releasing factor receptor type 2 in the bed nucleus of stria terminalis improves posttraumatic stress disorder-like symptoms in a model of incubation of fear
    Einat Elharrar
    The Leslie and Susan Gonda Goldschmied Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan
    Biol Psychiatry 74:827-36. 2013
    ..is involved in activation of the central stress response, while corticotropin-releasing factor receptor type 2 (CRFR2) has been suggested to mediate termination of this response...
  64. pmc Effects of continuously enhanced corticotropin releasing factor expression within the bed nucleus of the stria terminalis on conditioned and unconditioned anxiety
    K S Sink
    Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Center, Emory University, Atlanta, GA 30329, USA
    Mol Psychiatry 18:308-19. 2013
    ..did not affect plasma corticosterone concentration but did decrease CRFR1 receptor density within the BNST and CRFR2 receptor density within the dorsal portion of the caudal dorsal raphe nucleus...
  65. pmc Quantitative trait locus for body weight identified on rat chromosome 4 in inbred alcohol-preferring and -nonpreferring rats: potential implications for neuropeptide Y and corticotrophin releasing hormone 2
    John Paul Spence
    Department of Psychiatry, Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, IN 46202, USA
    Alcohol 47:63-7. 2013
    ..Y (Npy), juxtaposed with another zinc finger gene 1 (Jazf1), corticotrophin releasing factor receptor 2 (Crfr2) and LanC lantibiotic synthetase component C-like 2 (Lancl2)...
  66. doi Aging-related changes in cutaneous corticotropin-releasing hormone system reflect a defective neuroendocrine-stress response in aging
    Rana Mohsen Elewa
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Rejuvenation Res 15:366-73. 2012
    ..However, a consistent logic interaction between the different CRH system components and the aging process has, to our knowledge, never been examined before...
  67. doi Urocortin-dependent effects on adrenal morphology, growth, and expression of steroidogenic enzymes in vivo
    Anna Riester
    Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, Hospital of the Ludwig Maximilians University, Ziemssenstrasse 1, D 80336 Munich, Germany
    J Mol Endocrinol 48:159-67. 2012
    ..factor (CRF) family that display varying affinities to the CRF receptor 1 (CRFR1 (CRHR1)) and 2 (CRFR2 (CRHR2))...
  68. doi Susceptibility to PTSD-like behavior is mediated by corticotropin-releasing factor receptor type 2 levels in the bed nucleus of the stria terminalis
    Maya Lebow
    Departments of Neurobiology and Veterinary Resources, Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 32:6906-16. 2012
    ..Corticotropin-releasing factor receptor type 2 (CRFR2) has been implicated in mediating stress coping mechanisms...
  69. doi Activation of CRHR2 exerts an inhibitory effect on the expression of collapsin response mediator protein 3 in hippocampal neurons
    Yanming Chen
    Department of Physiology and The Key Laboratory of Molecular Neurobiology of Ministry of Education, Second Military Medical University, Shanghai 200433, PR China
    Neuropeptides 46:93-8. 2012
    ..In the present study, we determined the effects of CRHR1 and CRHR2 on CRMP3 expression in cultured hippocampal neurons...
  70. ncbi Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2
    J Radulovic
    Max Planck Institute for Experimental Medicine, Department for Molecular Neuroendocrinology, 37075 Goettingen, Germany
    J Neurosci 19:5016-25. 1999
    ..of learning and anxiety by corticotropin-releasing factor (CRF) through CRF receptor subtypes 1 (CRFR1) and 2 (CRFR2) is demonstrated. As learning paradigm, context- and tone-dependent fear conditioning of the mouse was used...
  71. pmc Clinical perspectives of urocortin and related agents for the treatment of cardiovascular disease
    Keiichi Ikeda
    Department of Molecular Cell Biology, Institute of DNA Medicine, Research Center for Medical Sciences, Jikei University School of Medicine, Tokyo 105 8461, Japan
    Int J Endocrinol 2012:198628. 2012
    ..also been intensively scrutinized following the cloning and identification of its receptor, CRF receptor type 2 (CRFR2), in peripheral tissues including the heart...
  72. doi Activation of corticotropin releasing factor receptor type 2 in the heart by corticotropin releasing factor offers cytoprotection against ischemic injury via PKA and PKC dependent signaling
    Anne K Jonassen
    Department of Biomedicine, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway
    Regul Pept 174:90-7. 2012
    Corticotrophin-releasing factor receptor 2β (CRFR2β) is expressed in the myocardium...
  73. pmc Predicting risk of bacterial vaginosis: the role of race, smoking and corticotropin-releasing hormone-related genes
    K K Ryckman
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA
    Mol Hum Reprod 15:131-7. 2009
    ..04 for both). These data indicate that susceptibility to BV is affected by patterns of genetic variation in stress-related genes and smoking plays an important role...
  74. doi Activation of corticotropin-releasing factor receptor 2 inhibits the growth of human small cell lung carcinoma cells
    Juejin Wang
    Department of Pharmacology, Nanjing Medical University, Nanjing, China
    Cancer Invest 28:146-55. 2010
    Previously, we found the activation of corticotropin-releasing factor receptor 2 (CRFR2) could inhibit tumor growth via an anti-angiogenic pathway, implying CRFR2 may be a tumor therapeutic target...
  75. doi Urocortin 2 stimulates estradiol secretion from cultured human placental cells: an effect mediated by the type 2 corticotrophin-releasing hormone (CRH) receptor
    Alberto Imperatore
    Department of Paediatrics, Obstetrics, and Reproductive Medicine, University of Siena, Italy
    Reprod Sci 16:551-8. 2009
    ..Our results suggest that urocortin 2 may play a role in the regulation of E2 production throughout pregnancy, thereby contributing to the placental regulation of key reproductive events in pregnancy maintenance and parturition...
  76. ncbi From QTL to candidate gene: a genetic approach to alcoholism research
    John P Spence
    Department of Psychiatry, Indiana University School of Medicine, Institute of Psychiatry, Indianapolis, IN 46202, USA
    Curr Drug Abuse Rev 2:127-34. 2009
    ..candidate genes, neuropeptide Y (Npy), alpha-synuclein (Snca), and corticotrophin-releasing factor receptor 2 (Crhr2), have been identified that may account for the linkage signal...
  77. pmc Urocortin and corticotropin-releasing factor receptor 2 in human renal cell carcinoma: disruption of an endogenous inhibitor of angiogenesis and proliferation
    Hossein Tezval
    Department of Urology and Urological Oncology, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    World J Urol 27:825-30. 2009
    ..Ucn) exerts its actions through activation of two corticotropin-releasing factor receptors (CRFRs), CRFR1 and CRFR2. Involvement of Ucn/CRFR2 system in pathophysiological conditions such as the regulation of angiogenesis and ..
  78. pmc Effects of voluntary running in the female mice lateral septum on BDNF and corticotropin-releasing factor receptor 2
    Sofia Gustafsson
    Division of Clinical Chemistry, Department of Clinical and Experimental Medicine, Linkoping University, 58183 Linkoping, Sweden
    Int J Pept 2011:932361. 2011
    ..In the present study we examined the effects of long-term voluntary exercise on the transcripts for BDNF and CRFR2 in the lateral septum (LS) and for CRF in the central amygdala (CeA) in female mice...
  79. pmc Pharmacogenetics of antidepressants
    Concetta Crisafulli
    Institute of Psychiatry, University of Bologna Bologna, Italy
    Front Pharmacol 2:6. 2011
    ..dopamine receptors (D2), the G protein beta 3 subunit, the corticotropin releasing hormone receptors (CRHR1 and CRHR2), the glucocorticoid receptors, the c-AMP response-element binding, and the brain-derived neurotrophic factor...
  80. doi Expression of urocortin and corticotropin-releasing hormone receptors in the bovine adrenal gland
    Caterina Squillacioti
    Department of Structure, Functions and Biological Technologies, University of Naples Federico II, Naples, Italy
    Gen Comp Endocrinol 172:416-22. 2011
    ..are mediated via two types of G protein-coupled receptors, CRH type 1 receptor (CRHR1) and CRH type 2 receptor (CRHR2)...
  81. pmc Expression and regulation of corticotropin-releasing factor receptor type 2β in developing and mature mouse skeletal muscle
    Yael Kuperman
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
    Mol Endocrinol 25:157-69. 2011
    Corticotropin-releasing factor receptor type 2 (CRFR2) is highly expressed in skeletal muscle (SM) tissue where it is suggested to inhibit interactions between insulin signaling pathway components affecting whole-body glucose homeostasis...
  82. pmc Association of HPA axis-related genetic variation with stress reactivity and aggressive behaviour in pigs
    Eduard Murani
    Research Unit Molecular Biology, Leibniz Institute for Farm Animal Biology FBN, Wilhelm Stahl Allee 2, D 18196 Dummerstorf, Germany
    BMC Genet 11:74. 2010
    ..293_298del, MC2R c.306T>G, NR3C1 c.*2122A>G, AVP c.207A>G, AVPR1B c.1084A>G, UCN g.1329T>C, CRHR2 c...
  83. doi The effects of repeated restraint stress on energy balance and behavior of mice with selective deletion of CRF receptors
    C Chotiwat
    Department of Foods and Nutrition, The University of Georgia, Athens, GA, 30602, USA
    Stress 13:203-13. 2010
    ..We tested the effect of RRS in mice deficient in corticotropin releasing factor receptor one (CRFR1-KO) or two (CRFR2-KO). Wild type (WT) and CRFR2-KO, but not CRFR1-KO, mice lost weight during RRS...
  84. pmc A polymorphism of the corticotropin-releasing hormone receptor 2 (CRHR2) and preterm birth
    Maximilian Schmid
    Department of Obstetrics and Feto maternal Medicine, Medical University of Vienna General Hospital, Vienna, Austria
    Dis Markers 28:37-42. 2010
    ..6). In conclusion, the investigated polymorphism does not increase the risk for preterm birth overall but might modulate the length of pregnancy in a dose dependent fashion in a series of Caucasian women...
  85. doi Modulation of calcium movements by urocortin II in endothelial cells
    Elena Grossini
    Laboratorio di Fisiologia, Dipartimento di Medicina Clinica e Sperimentale, Facolta di Medicina e Chirurgia, I 28100 Novara, Italy
    Cell Physiol Biochem 25:221-32. 2010
    ..In endothelial cells urocortin II has recently been found to activate nitric oxide synthase through cAMP-dependent and Ca(2+)-related pathway...
  86. doi Alterations in colonic corticotropin-releasing factor receptors in the maternally separated rat model of irritable bowel syndrome: differential effects of acute psychological and physical stressors
    Dervla O'Malley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Peptides 31:662-70. 2010
    ..6+/-4.4% vs. NS: 43.8+/-6.8%, p<0.001) and CRFR2 (MS: 65.9+/-3.2% vs. NS: 51.6+/-5.8%, p<0.05) positive cells in MS rats...
  87. pmc Corticotropin-releasing hormone receptor-1 in cerebral microvessels changes during development and influences urocortin transport across the blood-brain barrier
    Hung Hsuchou
    Blood Brain Barrier Group, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Endocrinology 151:1221-7. 2010
    ..The mRNA for CRHR2 was less abundant in both regions and less prone to changes with development or the agouti viable yellow mutation...
  88. doi Differential effect of prenatal stress on the expression of corticotrophin-releasing hormone and its receptors in the hypothalamus and amygdala in male and female rats
    I Zohar
    Department of Pharmacology, Institute of Drug Research, Hebrew University Medical Centre, Ein Kerem, Jerusalem, Israel
    J Neuroendocrinol 23:320-8. 2011
    ..together with changes in the gene expression of corticotrophin-releasing hormone (CRH), its receptors, CRHR1 and CRHR2, as well as CRH binding protein (CRH-BP) in the paraventricular nucleus (PVN) and amygdala of their male and ..
  89. doi Urocortin-1 and -2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits
    A Neufeld-Cohen
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Psychiatry 15:426-41, 339. 2010
    ..of the central stress response through the activation of corticotropin-releasing factor receptor type 2 (CRFR2)...
  90. doi Subtype-specific differences in corticotropin-releasing factor receptor complexes detected by fluorescence spectroscopy
    Laura Milan-Lobo
    Medical University of Vienna, Center for Biomolecular Medicine and Pharmacology, Institute of Pharmacology, Waehringerstrasse 13a, A 1090 Vienna, Austria
    Mol Pharmacol 76:1196-210. 2009
    ..Agonist stimulation of CRFR1 and CRFR2 gave rise to similar concentration-response curves for cAMP accumulation, but CRFR2 underwent restricted collision ..
  91. pmc Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior
    Alec Roy
    Psychiatry Service, Department of Veterans Affairs, New Jersey VA Health Care System, East Orange, NJ 07018 1095, USA
    J Psychiatr Res 46:72-9. 2012
    ..Haplotype-tagging SNPs were genotyped across CRHBP and, for completeness, across CRH, CRHR1 and CRHR2. FKBP5 genotypes were available...
  92. ncbi Low doses of corticotropin-releasing hormone injected into the dorsal raphe nucleus block the behavioral consequences of uncontrollable stress
    Sayamwong E Hammack
    Department of Psychiatry, Center for Behavioral Neuroscience, Emory University School of Medicine, Atlanta, GA 30322, USA
    Behav Brain Res 147:55-64. 2003
    ..LH because intra-DRN CRH produces LH at very high doses, and because intra-DRN antagonists for the CRH 2 receptor (CRHR2) block LH...
  93. ncbi Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2beta by the CRF/urocortin family of peptides
    Bhawanjit K Brar
    The Clayton Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Endocrinology 145:1718-29. 2004
    ..ERK1/2-p42, 44 by Ucn-I were extended to cell lines that endogenously express CRFR1 (AtT-20 and CATHa cells) and CRFR2 (A7r5 and CATHa cells)...
  94. ncbi Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians
    B G Challis
    University Departments of Medicine and Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, UK
    Int J Obes Relat Metab Disord 28:442-6. 2004
    ..To investigate whether genetic variation at the loci encoding the corticotropin-releasing factor receptors-1 and -2 (CRF-R1 and CRF-R2) contributes to human obesity...
  95. ncbi Corticotropin-releasing hormone system in human adipose tissue
    Janette Seres
    German Diabetes Center, Heinrich Heine University of Duesseldorf, Duesseldorf 65 40225, Germany
    J Clin Endocrinol Metab 89:965-70. 2004
    ..This system could be implicated in energy homeostasis and in mediating the anorexic effects of CRH at adipose level...
  96. ncbi Antalarmin blockade of corticotropin releasing hormone-induced hypertension in rats
    R J Briscoe
    Department of Pharmacology, University of Michigan, 48109, Ann Arbor, MI, USA
    Brain Res 881:204-7. 2000
    ..of antalarmin, a novel, small molecule CRH1 receptor antagonist, and alpha-helical CRH(9-41), a peptidic CRHR1/CRHR2 antagonist to attempt to determine the receptor mechanisms through which CRH is acting in both of these situations...
  97. ncbi Elevated stress sensitivity in corticotropin-releasing factor receptor 2 deficient mice decreases maternal, but not intermale aggression
    Stephen C Gammie
    Department of Zoology, University of Wisconsin, 1117 West Johnson St, Madison, WI 53706, USA
    Behav Brain Res 160:169-77. 2005
    ..Recent work indicates that mice deficient in CRF receptor 2 (CRFR2) display increased anxiety-like behaviors, have a hypersensitive stress response, and overproduce CRF...
  98. ncbi Urocortin 1 and Urocortin 2 induce macrophage apoptosis via CRFR2
    Christos Tsatsanis
    Department of Clinical Chemistry Biochemistry, School of Medicine, University of Crete, Heraklion, Crete GR 710 03, Greece
    FEBS Lett 579:4259-64. 2005
    ..Macrophages express the Corticotropin-Releasing Factor Receptor-2 (CRFR2) the endogenous agonists of which, the urocortins, are also present at the site of inflammation...
  99. ncbi Large-scale search of single nucleotide polymorphisms for hepatocellular carcinoma susceptibility genes in patients with hepatitis C
    Naoya Kato
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Hepatology 42:846-53. 2005
    ..05). Of these 31 SNPs, 3 SNPs of 3 genes (SCYB14, GFRA1, and CRHR2) were significantly associated with HCC in a secondary screening...
  100. ncbi Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior
    Tracy L Bale
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 22:193-9. 2002
    ..coordinators of homeostasis whose actions are mediated through their receptors, CRF receptor 1 (CRFR1) and CRFR2, found throughout the CNS and periphery...

Research Grants71

  1. CRF Modulation of NMDA Currents and Behavior in the VTA
    Antonello Bonci; Fiscal Year: 2009
    ..The main goal of this project is to elucidate the role of CRFR1 and CRFR2 in promoting stress-enhanced relapse to cocaine seeking...
  2. Regulation and Function of Urocortins and their Receptors
    Aditi Bhargava; Fiscal Year: 2010
    ..factor (CRF) family of neuropeptides (CRF and urocortins [Ucn] 1-3) and their receptors (CRFR1, CRFR2) are essential mediators of stress in the central nervous system...
  3. Regulation and Function of Urocortins and their Receptors
    Aditi Bhargava; Fiscal Year: 2010
    ..factor (CRF) family of neuropeptides (CRF and urocortins [Ucn] 1-3) and their receptors (CRFR1, CRFR2) are essential mediators of stress in the central nervous system...
  4. Central neural function of Urocortin 3 in regulating energy balance
    Chien Li; Fiscal Year: 2010
    ..The receptor for Ucn 3, the type 2 CRF receptor (CRFR2), is highly expressed in the VMH and its expression is regulated by the energy status of the animals...
  5. Serotonin and CRF Pathways in Anxiety & HPA Regulation
    Anantha Shekhar; Fiscal Year: 2007
    ..2) To determine that repeated stimulation of CRF receptors, either CRF type 1 or 2 receptors (CRFR1 and CRFR2, respectively) within the above network results in 'priming' of chronic anxiety/stress states...
  6. Stress and CRF Signaling in Alzheimer?s Disease Pathogenesis
    PAUL E contact SAWCHENKO; Fiscal Year: 2010
    ..by disruption of signaling via the type 1 corticotropin-releasing factor receptor (CRFR1) and exaggerated in CRFR2-deficient mice...
  7. ROLE OF UROCORTIN IN MAMMALIAN BRAIN AND PITUITARY
    AUDREY SEASHOLTZ; Fiscal Year: 2004
    ..urocortin, is 43 percent identical to CRH and binds to both of its receptors, albeit with a higher affinity to CRHR2. Because CRH and urocortin can bind to and activate both CRH receptors, iv or icv administration of urocortin ..
  8. Bimolecular interactions of CRF ligands and receptors
    Abdul Abou Samra; Fiscal Year: 2006
    ..an oxidation-resistant radio labeled sauvagine analog (YQLS), that can be covalently cross linked to CRFR1 and CRFR2, using a chemical cross linking agent that cross links lysine residues...
  9. CRF Modulation of NMDA Currents and Behavior in the VTA
    Matthijs Verhage; Fiscal Year: 2010
    ..The main goal of this project is to elucidate the role of CRFR1 and CRFR2 in promoting stress-enhanced relapse to cocaine seeking...
  10. CRF Dysregulation in Serotonin Neurotransmission and Stress Responsivity
    Jonathan McEuen; Fiscal Year: 2007
    ..Analysis will utilize stress-sensitive transgenic mice deficient in the CRF type 2 receptor (CRFR2)...
  11. Early Gestation as a Sensitive Period to Stress in Sex-Dependent Neurodevelopment
    Tracy L Bale; Fiscal Year: 2010
    ....
  12. Early pregnancy stress programming of offspring emotionality
    Tracy L Bale; Fiscal Year: 2010
    ....
  13. Actions of CRF on 5-HT pathways in mood regulation
    TRACY BALE; Fiscal Year: 2009
    ..These mice will be crossed with our CRFR2-deficient mice to produce mice with elevated amygdalar CRF and deficient in CRFR1 in 5-HT cells...
  14. Actions of CRF on 5-HT pathways in mood regulation
    Tracy L Bale; Fiscal Year: 2011
    ..Utilizing CRF receptor-2 (CRFR2) deficient mice in which disruption of normal stress neurocircuitry prevents the recruitment and promotion of ..
  15. Perioculomotor area and alcohol
    Andrey Ryabinin; Fiscal Year: 2009
    ..These studies will provide novel important information indicating how these recently identified neurons robustly regulate alcohol intake. ..
  16. NEUROANATOMICAL SUBSTRATES OF ALCOHOL-INDUCED AMNESIA
    Andrey Ryabinin; Fiscal Year: 2001
    ..Taken together, these studies will provide valuable insight at several levels of analysis of alcohol~s action on cognitive functions and eventually allow to start understanding of the mechanisms involved in alcohol-induced amnesia. ..
  17. NO AND CO MEDIATE MENTAL-NEUROENDOCRINE INTERACTIONS
    Catherine Rivier; Fiscal Year: 2004
    ..Collectively, these results will provide novel and comprehensive information regarding the neurocircuitries through which NO or CO modulate the response of the rat HPA to a neurogenic stress. ..
  18. Mechanisms of Fatigue in a Chronic Viral Disease
    LINDA TOTH; Fiscal Year: 2009
    ..Such a long-term result would improve the quality of life and economic welfare of target populations that span many disease conditions. ..
  19. Facility renovation to expand mouse barrier space
    LINDA TOTH; Fiscal Year: 2005
    ..This space will not be adequate to support our anticipated continued growth in the areas of infectious disease and toxic challenge and in the need for quarantine of non-vendor rodents. ..
  20. Neural Analysis of Maternal Aggression
    STEPHEN GAMMIE; Fiscal Year: 2006
    ..Basic research into sex differences in aggression, then, is important to understanding the biological underpinnings of sex and gender differences in social behavior, health, and disease. ..
  21. BEHAVIORAL AND PHYSIOLOGIC PATHOBIOLOGY OF MICE
    LINDA TOTH; Fiscal Year: 2006
    ..abstract_text> ..
  22. Urocortin III: Regulation and Function in the Islet
    Chien Li; Fiscal Year: 2005
    ..The additional knowledge and research skills acquired from the application, together with previous background, will enable the applicant to study complicated, multifaceted metabolic disorders such as diabetes mellitus ..
  23. A NOVEL NEURAL PATHWAY CONTROLS TESTOSTERONE RELEASE
    Catherine Rivier; Fiscal Year: 2003
    ..These experiments will provide the first morphological and functional evidence of the existence of a multisynaptic neural pathway between the testes and the CNS, that is influenced by alcohol. ..
  24. Modulation of BNST 5-HT responses by corticosterone
    SAYAMWONG HAMMACK; Fiscal Year: 2006
    ....