Gene Symbol: CRHR1
Description: corticotropin releasing hormone receptor 1
Alias: CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRFR1, CRH-R-1, CRH-R1, CRHR, CRHR1L, corticotropin-releasing factor receptor 1, CRH receptor 1, corticotropin-releasing factor type 1 receptor, seven transmembrane helix receptor
Species: human
Products:     CRHR1

Top Publications

  1. Hillhouse E, Grammatopoulos D. The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Endocr Rev. 2006;27:260-86 pubmed
    ..The type of activating agonist, receptor, and target cell appears to play a major role in determining the overall signaling and biological responses in health and disease. ..
  2. Keck M, Kern N, Erhardt A, Unschuld P, Ising M, Salyakina D, et al. Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1196-204 pubmed publisher
    ..susceptibility to anxiety disorders in humans, we genotyped 71 single nucleotide polymorphisms (SNPs) in CRH, CRHR1, CRHR2, AVP, AVPR1A, AVPR1B in a German sample from Munich with patients suffering from panic disorder and matched ..
  3. Hollenstein K, Kean J, Bortolato A, Cheng R, Doré A, Jazayeri A, et al. Structure of class B GPCR corticotropin-releasing factor receptor 1. Nature. 2013;499:438-43 pubmed publisher
    ..This structure provides a model for all class B GPCRs and may aid in the design of new small-molecule drugs for diseases of brain and metabolism. ..
  4. Grammatopoulos D, Dai Y, Randeva H, Levine M, Karteris E, Easton A, et al. A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes. Mol Endocrinol. 1999;13:2189-202 pubmed
    ..Furthermore, CRH failed to stimulate inositol trisphosphate production. Coexpression studies between the CRH-R1d or CRH-R1alpha showed that this receptor does not play a role as a dominant negative receptor for CRH. ..
  5. Binder E, Nemeroff C. The CRF system, stress, depression and anxiety-insights from human genetic studies. Mol Psychiatry. 2010;15:574-88 pubmed publisher
    ..In-depth characterization of these variants will likely be important in furthering our understanding of the long-term consequences of adverse experience. ..
  6. Tyrka A, Price L, Gelernter J, Schepker C, Anderson G, Carpenter L. Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity. Biol Psychiatry. 2009;66:681-5 pubmed publisher
    Variation in the corticotropin-releasing hormone receptor (CRHR1) gene has been shown to interact with early life stress to predict adult depression...
  7. Liu Z, Zhu F, Wang G, Xiao Z, Wang H, Tang J, et al. Association of corticotropin-releasing hormone receptor1 gene SNP and haplotype with major depression. Neurosci Lett. 2006;404:358-62 pubmed
    ..In this article, whether genetic variations in the corticotropin-releasing hormone receptor1 (CRHR1) gene might be associated with increased susceptibility to major depression was studied by using a gene-based ..
  8. DeYoung C, Cicchetti D, Rogosch F. Moderation of the association between childhood maltreatment and neuroticism by the corticotropin-releasing hormone receptor 1 gene. J Child Psychol Psychiatry. 2011;52:898-906 pubmed publisher
    ..Variation in three polymorphisms of the CRHR1 gene has been found to moderate the association of childhood maltreatment with depression, and we hypothesized ..
  9. Teli T, Markovic D, Levine M, Hillhouse E, Grammatopoulos D. Regulation of corticotropin-releasing hormone receptor type 1alpha signaling: structural determinants for G protein-coupled receptor kinase-mediated phosphorylation and agonist-mediated desensitization. Mol Endocrinol. 2005;19:474-90 pubmed
    ..Based on our identification of key amino acid(s) for GRK-dependent phosphorylation, we demonstrate the importance of the CRH-R1alpha carboxyl tail for regulation of receptor activity. ..

More Information


  1. Licinio J, O Kirwan F, Irizarry K, Merriman B, Thakur S, Jepson R, et al. Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans. Mol Psychiatry. 2004;9:1075-82 pubmed
    ..b>CRH receptor 1 (CRHR1), which we first mapped in the brain in 1994, has been implicated in the treatment of depression and ..
  2. Bradley R, Binder E, Epstein M, Tang Y, Nair H, Liu W, et al. Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch Gen Psychiatry. 2008;65:190-200 pubmed publisher
    ..symptoms are moderated by genetic polymorphisms within the corticotropin-releasing hormone type 1 receptor (CRHR1) gene...
  3. Hsu D, Mickey B, Langenecker S, Heitzeg M, Love T, Wang H, et al. Variation in the corticotropin-releasing hormone receptor 1 (CRHR1) gene influences fMRI signal responses during emotional stimulus processing. J Neurosci. 2012;32:3253-60 pubmed publisher
    ..Recent reports suggest that GG-homozygous individuals of a single nucleotide polymorphism (rs110402) in the CRH receptor 1 (CRHR1) gene show behavioral and neuroendocrine evidence of stress vulnerability...
  4. Wetzka B, Sehringer B, Schafer W, Biller S, Hor C, Benedek E, et al. Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term. Exp Clin Endocrinol Diabetes. 2003;111:154-61 pubmed
    ..b>CRH receptor 1 mRNA was detected in all tissues investigated by RT-PCR, whereas CRH receptor 2 mRNA was restricted to ..
  5. Chen R, Lewis K, Perrin M, Vale W. Expression cloning of a human corticotropin-releasing-factor receptor. Proc Natl Acad Sci U S A. 1993;90:8967-71 pubmed
    ..We also describe an alternatively spliced form of the receptor which includes an insert of 29 amino acids in the first intracellular loop. ..
  6. Polanczyk G, Caspi A, Williams B, Price T, Danese A, Sugden K, et al. Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension. Arch Gen Psychiatry. 2009;66:978-85 pubmed publisher
    ..a gene x environment interaction in which a haplotype in the corticotropin-releasing hormone receptor 1 gene (CRHR1) was associated with protection against adult depressive symptoms in individuals who were maltreated as children (..
  7. Pisarchik A, Slominski A. Molecular and functional characterization of novel CRFR1 isoforms from the skin. Eur J Biochem. 2004;271:2821-30 pubmed
    In our continued studies on corticotropin releasing factor receptor (CRFR1) signaling in the skin, we tested functional activity of CRFR1alpha, e, f, g and h isoforms after transfection to COS cells...
  8. Papadopoulou N, Chen J, Randeva H, Levine M, Hillhouse E, Grammatopoulos D. Protein kinase A-induced negative regulation of the corticotropin-releasing hormone R1alpha receptor-extracellularly regulated kinase signal transduction pathway: the critical role of Ser301 for signaling switch and selectivity. Mol Endocrinol. 2004;18:624-39 pubmed
    ..Phosphorylation by PKA prevents maximal coupling of the CRH-R1alpha to Gq-protein, and thereby reduces activation of ERK 1/2. ..
  9. Grammatopoulos D, Dai Y, Chen J, Karteris E, Papadopoulou N, Easton A, et al. Human corticotropin-releasing hormone receptor: differences in subtype expression between pregnant and nonpregnant myometria. J Clin Endocrinol Metab. 1998;83:2539-44 pubmed
    ..These findings suggest that CRH receptor expression plays an important modulatory role in myometrial and possibly in cervical function. ..
  10. Markovic D, Lehnert H, Levine M, Grammatopoulos D. Structural determinants critical for localization and signaling within the seventh transmembrane domain of the type 1 corticotropin releasing hormone receptor: lessons from the receptor variant R1d. Mol Endocrinol. 2008;22:2505-19 pubmed publisher
    ..This mechanism appears to involve accelerated CRH-R2beta endocytosis. ..
  11. Lewis K, Li C, Perrin M, Blount A, Kunitake K, Donaldson C, et al. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc Natl Acad Sci U S A. 2001;98:7570-5 pubmed
    ..Urocortin III is selective for type 2 CRF receptors and thus represents another potential endogenous ligand for these receptors. ..
  12. McLean M, Bisits A, Davies J, Woods R, Lowry P, Smith R. A placental clock controlling the length of human pregnancy. Nat Med. 1995;1:460-3 pubmed
  13. Ribbe K, Ackermann V, Schwitulla J, Begemann M, Papiol S, Grube S, et al. Prediction of the risk of comorbid alcoholism in schizophrenia by interaction of common genetic variants in the corticotropin-releasing factor system. Arch Gen Psychiatry. 2011;68:1247-56 pubmed publisher
    ..Genotype analysis comprising selected single-nucleotide polymorphisms within the CRHR1 and CRHBP genes in patients with schizophrenia and in a nonschizophrenic psychiatric disease control sample should ..
  14. Treutlein J, Kissling C, Frank J, Wiemann S, Dong L, Depner M, et al. Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples. Mol Psychiatry. 2006;11:594-602 pubmed
    To investigate the role of the corticotropin releasing hormone receptor 1 (CRHR1) in patterns of human alcohol drinking and its potential contribution to alcohol dependence, we analysed two independent samples: a sample of adolescents, ..
  15. Zmijewski M, Slominski A. CRF1 receptor splicing in epidermal keratinocytes: potential biological role and environmental regulations. J Cell Physiol. 2009;218:593-602 pubmed publisher
    Corticotropin releasing factor receptor type 1 (CRF1), a coordinator of the body responses to stress, is also expressed in human skin, where it undergoes alternative splicing...
  16. Pisarchik A, Slominski A. Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression. FASEB J. 2001;15:2754-6 pubmed
    ..We suggest that a polymorphism of CRH-R1 expression is related to anatomic location, skin physiological or pathologic status, specific cell type, and external stress (UV), and that cAMP-dependent pathways and TPA may regulate CRH-R1. ..
  17. Graziani G, Tentori L, Portarena I, Barbarino M, Tringali G, Pozzoli G, et al. CRH inhibits cell growth of human endometrial adenocarcinoma cells via CRH-receptor 1-mediated activation of cAMP-PKA pathway. Endocrinology. 2002;143:807-13 pubmed
    ..Experiments with the PKA inhibitor 14-22 amide and forskolin, as well as the measurement of intracellular cAMP, suggested the downstream involvement of cAMP-PKA pathway in CRH-induced inhibition of Ishikawa cell growth. ..
  18. Vita N, Laurent P, Lefort S, Chalon P, Lelias J, Kaghad M, et al. Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors. FEBS Lett. 1993;335:1-5 pubmed
    ..A 2.7 kb mRNA coding for the CRF receptor could be detected in AtT20 cells and human cortex tissue. PCR analysis also detected the receptor transcript in human pituitary, brainstem, and testis. ..
  19. Kim W, Sheen S, Kim T, Huh J, Lee J, Kim E, et al. Association between CRHR1 polymorphism and improved lung function in response to inhaled corticosteroid in patients with COPD. Respirology. 2009;14:260-3 pubmed publisher
    ..An association between sequence variants in the corticotrophin-releasing hormone receptor 1 (CRHR1) gene and improved lung function in asthmatics treated with inhaled corticosteroids was reported recently...
  20. Kaprara A, Pazaitou Panayiotou K, Chemonidou M, Constantinidis T, Lambropoulou M, Koffa M, et al. Distinct distribution of corticotropin releasing factor receptors in human breast cancer. Neuropeptides. 2010;44:355-61 pubmed publisher
    ..CRF receptors could serve as targets of endogenous ligands expressed in the tumor microenvironment, regulating cancer growth. ..
  21. Blomeyer D, Treutlein J, Esser G, Schmidt M, Schumann G, Laucht M. Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use. Biol Psychiatry. 2008;63:146-51 pubmed
    Recent animal research suggests that alterations in the corticotropin releasing hormone receptor 1 (CRHR1) may lead to heavy alcohol use following repeated stress...
  22. Ressler K, Bradley B, Mercer K, Deveau T, Smith A, Gillespie C, et al. Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:812-24 pubmed publisher
    ..been separately identified in the stress-sensitive serotonergic (5-HTTLPR) and corticotropin-releasing hormone (CRHR1) systems...
  23. Cicchetti D, Rogosch F, Oshri A. Interactive effects of corticotropin releasing hormone receptor 1, serotonin transporter linked polymorphic region, and child maltreatment on diurnal cortisol regulation and internalizing symptomatology. Dev Psychopathol. 2011;23:1125-38 pubmed publisher
    ..Variation in the corticotropin releasing hormone receptor 1 (CRHR1) TAT haplotype and serotonin transporter linked polymorphic region (5-HTTLPR) was determined in a sample of ..
  24. Nelson E, Agrawal A, Pergadia M, Wang J, Whitfield J, Saccone F, et al. H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence. Addict Biol. 2010;15:1-11 pubmed publisher
    ..genotype x environment (G x E) interaction involving rs1876831, a corticotropin-releasing hormone receptor 1 (CRHR1) polymorphism, and negative events. CRHR1 and at least four other genes are located at 17q21...
  25. Kranzler H, Feinn R, Nelson E, Covault J, Anton R, Farrer L, et al. A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African-American women. Am J Med Genet B Neuropsychiatr Genet. 2011;156B:960-8 pubmed publisher
    ..depression and substance dependence, possibly mediated by the corticotropin-releasing hormone type 1 receptor (CRHR1)...
  26. Perrin M, Fischer W, Kunitake K, Craig A, Koerber S, Cervini L, et al. Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptor. J Biol Chem. 2001;276:31528-34 pubmed
    The first extracellular domain (ECD-1) of the corticotropin releasing factor (CRF) type 1 receptor, (CRFR1), is important for binding of CRF ligands...
  27. Jin D, He P, You X, Zhu X, Dai L, He Q, et al. Expression of corticotropin-releasing hormone receptor type 1 and type 2 in human pregnant myometrium. Reprod Sci. 2007;14:568-77 pubmed
    ..A heterogeneous distribution of CRH-R1 variants in term labor and nonlabor myometrium might be related to the effects of CRH on contractile phenotype of myometrium at the term. ..
  28. Minas V, Rolaki A, Kalantaridou S, Sidiropoulos J, Mitrou S, Petsas G, et al. Intratumoral CRH modulates immuno-escape of ovarian cancer cells through FasL regulation. Br J Cancer. 2007;97:637-45 pubmed
    ..Here, we examined immunohistochemically the expression of CRH, CRHR1, CRHR2 and FasL in 47 human ovarian cancer cases...
  29. Punn A, Levine M, Grammatopoulos D. Identification of signaling molecules mediating corticotropin-releasing hormone-R1alpha-mitogen-activated protein kinase (MAPK) interactions: the critical role of phosphatidylinositol 3-kinase in regulating ERK1/2 but not p38 MAPK activation. Mol Endocrinol. 2006;20:3179-95 pubmed
    ..In conclusion, a complex signaling network appears to mediate CRH-R1alpha-MAPK interactions; PI3-K might play a critical role in the regulation of CRH-R1alpha signaling selectivity and cellular responses. ..
  30. Miceli F, Ranelletti F, Martinelli E, Petrillo M, Scambia G, Navarra P, et al. Expression and subcellular localization of CRH and its receptors in human endometrial cancer. Mol Cell Endocrinol. 2009;305:6-11 pubmed publisher
    ..Positive correlations were found between CRH-R1 and PR expression, as well as between CRH-R2 cytoplasmic pattern and more advanced FIGO stage disease, respectively. ..
  31. Grace C, Perrin M, Gulyas J, Rivier J, Vale W, Riek R. NMR structure of the first extracellular domain of corticotropin-releasing factor receptor 1 (ECD1-CRF-R1) complexed with a high affinity agonist. J Biol Chem. 2010;285:38580-9 pubmed publisher
    ..Rivier, C., Perrin, M., Koerber, S. C., Sutton, S., Corrigan, A., Lahrichi, S. L., Craig, A. G., Vale, W., and Rivier, J. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 10575-10579). ..
  32. Liu Z, Zhu F, Wang G, Xiao Z, Tang J, Liu W, et al. Association study of corticotropin-releasing hormone receptor1 gene polymorphisms and antidepressant response in major depressive disorders. Neurosci Lett. 2007;414:155-8 pubmed
    ..the polymorphisms of three sites (rs1876828, rs242939 and rs242941) in corticotropin-releasing hormone receptor1 (CRHR1) gene are related to 6 weeks fluoxetine antidepressant effect in 127 Han Chinese patients with MDD...
  33. Pioszak A, Parker N, Suino Powell K, Xu H. Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1. J Biol Chem. 2008;283:32900-12 pubmed publisher
    The bimolecular interaction between corticotropin-releasing factor (CRF), a neuropeptide, and its type 1 receptor (CRFR1), a class B G-protein-coupled receptor (GPCR), is crucial for activation of the hypothalamic-pituitary-adrenal axis ..
  34. Wietfeld D, Heinrich N, Furkert J, Fechner K, Beyermann M, Bienert M, et al. Regulation of the coupling to different G proteins of rat corticotropin-releasing factor receptor type 1 in human embryonic kidney 293 cells. J Biol Chem. 2004;279:38386-94 pubmed
    ..Corresponding to a high and low affinity ligand binding site, sauvagine and other peptidic CRFR1 ligands evoked high and low potency responses of G protein activation, differing by 64-fold in their EC(50) values ..
  35. Heim C, Bradley B, Mletzko T, Deveau T, Musselman D, Nemeroff C, et al. Effect of Childhood Trauma on Adult Depression and Neuroendocrine Function: Sex-Specific Moderation by CRH Receptor 1 Gene. Front Behav Neurosci. 2009;3:41 pubmed publisher
    Variations of the corticotropin-releasing hormone receptor 1 (CRHR1) gene appear to moderate the development of depression after childhood trauma. Depression more frequently affects women than men...
  36. Gao L, Lu C, Xu C, Tao Y, Cong B, Ni X. Differential regulation of prostaglandin production mediated by corticotropin-releasing hormone receptor type 1 and type 2 in cultured human placental trophoblasts. Endocrinology. 2008;149:2866-76 pubmed publisher
  37. Davis E, Keller J, Hallmayer J, Pankow H, Murphy G, Gotlib I, et al. Corticotropin-releasing factor 1 receptor haplotype and cognitive features of major depression. Transl Psychiatry. 2018;8:5 pubmed publisher
    ..A haplotype of alleles T-A-T in a set of common polymorphisms in the gene encoding for CRF1 (CRHR1) has been associated with both depression vulnerability and alterations in cognitive functioning...
  38. Womersley J, Martin L, van der Merwe L, Seedat S, Hemmings S. Hypothalamic-pituitary-adrenal axis variants and childhood trauma influence anxiety sensitivity in South African adolescents. Metab Brain Dis. 2018;33:601-613 pubmed publisher
    ..We examined whether genetic variation in three stress response genes, CRHR1, NR3C1, and FKBP5, interact with childhood trauma (CT) to predict AS in South African adolescents...
  39. Skorzewska A, Wislowska Stanek A, Lehner M, Turzynska D, Sobolewska A, Krzascik P, et al. Corticotropin releasing factor receptor 1 antagonist differentially inhibits freezing behavior and changes gamma-aminobutyric acidergic activity in the amygdala in low- and high-anxiety rats. J Physiol Pharmacol. 2017;68:35-46 pubmed
    ..This knowledge can be applied to further elucidate the pathophysiology of anxiety and trauma/stress-related disorders. ..
  40. Opdenakker G, Fiten P, Nys G, Froyen G, van Roy N, Speleman F, et al. The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12. Genomics. 1994;21:403-8 pubmed
    ..SCYA7 was assigned as the locus symbol of the MCP-3 gene. Double-labeling experiments confirmed the regional assignment of the MCP-3 gene close to the ERBB2 locus on human chromosome 17. ..
  41. Demers C, Drabant Conley E, Bogdan R, Hariri A. Interactions Between Anandamide and Corticotropin-Releasing Factor Signaling Modulate Human Amygdala Function and Risk for Anxiety Disorders: An Imaging Genetics Strategy for Modeling Molecular Interactions. Biol Psychiatry. 2016;80:356-62 pubmed publisher
    ..interactions between genetic polymorphisms associated with differential anandamide (FAAH rs324420) and CRF1 (CRHR1 rs110402) signaling modulate amygdala function and anxiety disorder diagnosis...
  42. Pomrenze M, Millan E, Hopf F, Keiflin R, Maiya R, Blasio A, et al. A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits. Front Neurosci. 2015;9:487 pubmed publisher
    ..The CRF1 receptor antagonist R121919 reduced this Fos induction by two-thirds in these regions...
  43. Holliday K, Macfarlane G, Nicholl B, Creed F, Thomson W, McBeth J. Genetic variation in neuroendocrine genes associates with somatic symptoms in the general population: results from the EPIFUND study. J Psychosom Res. 2010;68:469-74 pubmed publisher
    ..8) were selected for serotoninergic system genes (TPH2, SLC6A4 and HTR2A) and HPA axis genes (CRH, CRHR1, CRHBP, MC2R, POMC, NR3C1, and SERPINA6) and genotyped using Sequenom technology...
  44. Owens G, Lawrence K, Jackson T, Crosbie E, Sayan B, Kitchener H, et al. Urocortin suppresses endometrial cancer cell migration via CRFR2 and its system components are differentially modulated by estrogen. Cancer Med. 2017;6:408-415 pubmed publisher
    ..This effect appears to be specific to CRF receptor 2 (CRFR2), as selective antagonism of CRFR2 but not CRFR1 completely eliminated suppression of migration...
  45. Dunlop B, Binder E, Iosifescu D, Mathew S, Neylan T, Pape J, et al. Corticotropin-Releasing Factor Receptor 1 Antagonism Is Ineffective for Women With Posttraumatic Stress Disorder. Biol Psychiatry. 2017;82:866-874 pubmed publisher
  46. Araújo D, de Sousa Lima P, Baeza L, Parente A, Melo Bailão A, Borges C, et al. Employing proteomic analysis to compare Paracoccidioides lutzii yeast and mycelium cell wall proteins. Biochim Biophys Acta Proteins Proteom. 2017;1865:1304-1314 pubmed publisher
    ..we detected some that are common to both fungal phases, such as Ecm33, and some specific proteins, as glucanase Crf1. All of those proteins were described in the metabolism of cell wall...
  47. Tenk J, Rostás I, Füredi N, Mikó A, Soós S, Solymár M, et al. Acute central effects of corticotropin-releasing factor (CRF) on energy balance: Effects of age and gender. Peptides. 2016;85:63-72 pubmed publisher
    ..Catabolic effects of CRF were shown to be mediated by both CRF1 (hypermetabolism) and CRF2 (anorexia) receptors...
  48. Young S, Griffante C, Aguilera G. Dimerization between vasopressin V1b and corticotropin releasing hormone type 1 receptors. Cell Mol Neurobiol. 2007;27:439-61 pubmed
    ..and interaction of pituitary VP V1b receptor (V1bR) and corticotropin releasing hormone receptor type 1 (CRHR1) are critical for hypothalamic pituitary adrenal (HPA) axis adaptation, but it is unknown whether this involves ..
  49. Rajkumar R, Wu Y, Farooq U, Tan W, Dawe G. Stress activates the nucleus incertus and modulates plasticity in the hippocampo-medial prefrontal cortical pathway. Brain Res Bull. 2016;120:83-9 pubmed publisher
    ..To examine whether activation of CRF1 receptors in the NI plays a role in the suppression of HP-mPFC LTP, antalarmin, a specific CRF1 receptor antagonist,..
  50. Wootten D, Reynolds C, Koole C, Smith K, Mobarec J, Simms J, et al. A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures. Mol Pharmacol. 2016;89:335-47 pubmed publisher
    ..from recent crystal structures of the transmembrane domains of the glucagon and corticotropin releasing factor 1 (CRF1) receptors to develop improved models of the GLP-1 receptor that predict additional key molecular interactions with ..
  51. Inda C, Dos Santos Claro P, Bonfiglio J, Senin S, Maccarrone G, Turck C, et al. Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling. J Cell Biol. 2016;214:181-95 pubmed publisher
    Corticotropin-releasing hormone receptor 1 (CRHR1) activates G protein-dependent and internalization-dependent signaling mechanisms...
  52. Andolina D, Di Segni M, Bisicchia E, D Alessandro F, Cestari V, Ventura A, et al. Effects of lack of microRNA-34 on the neural circuitry underlying the stress response and anxiety. Neuropharmacology. 2016;107:305-316 pubmed publisher
    ..Differential GRM7, 5-HT2C, and CRFR1 mRNA expression was noted in the mpFC and BLA between TKO and WT mice...
  53. Larson A, Nunez M, Kissel C, Kovács K. Intrathecal urocortin I in the spinal cord as a murine model of stress hormone-induced musculoskeletal and tactile hyperalgesia. Eur J Neurosci. 2015;42:2772-82 pubmed publisher
    ..Urocortin I (a CRF1 and CRF2 receptor ligand) produced hyperalgesia in both assays when injected intrathecally (i.t...
  54. Kamdem L, Hamilton L, Cheng C, Liu W, Yang W, Johnson J, et al. Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia. Pharmacogenet Genomics. 2008;18:507-14 pubmed publisher
    ..Among the polymorphisms genotyped, we identified eight genes (CNTNAP2, LEPR, CRHR1, NTAN1, SLC12A3, ALPL, BGLAP, and APOB) containing variants that were associated with hypertension (chi2 P values ..
  55. Asakura H, Zwain I, Yen S. Expression of genes encoding corticotropin-releasing factor (CRF), type 1 CRF receptor, and CRF-binding protein and localization of the gene products in the human ovary. J Clin Endocrinol Metab. 1997;82:2720-5 pubmed
    ..The functionality of the ovarian CRF system may be conditioned by the relative presence of circulating CRF-BP by virtue of its ability to compete with CRF for the CRF receptor. ..
  56. Holmes K, Babwah A, Dale L, Poulter M, Ferguson S. Differential regulation of corticotropin releasing factor 1alpha receptor endocytosis and trafficking by beta-arrestins and Rab GTPases. J Neurochem. 2006;96:934-49 pubmed
    ..Taken together, our results suggest that beta-arrestin trafficking differs between HEK293 cells and neurons, and that CRF1alpha receptor resensitization is regulated in an atypical manner by Rab GTPases. ..
  57. Morisot N, Contarino A. The CRF1 and the CRF2 receptor mediate recognition memory deficits and vulnerability induced by opiate withdrawal. Neuropharmacology. 2016;105:500-507 pubmed publisher
    ..The corticotropin-releasing factor (CRF) system mediates stress responses via CRF1 and CRF2 receptors and may be implicated in substance use disorders...
  58. Morisot N, Millan M, Contarino A. CRF1 receptor-deficiency induces anxiety-like vulnerability to cocaine. Psychopharmacology (Berl). 2014;231:3965-72 pubmed publisher
    ..CRF signalling is mediated by two receptor types, named CRF1 and CRF2...
  59. Karteris E, Vatish M, Hillhouse E, Grammatopoulos D. Preeclampsia is associated with impaired regulation of the placental nitric oxide-cyclic guanosine monophosphate pathway by corticotropin-releasing hormone (CRH) and CRH-related peptides. J Clin Endocrinol Metab. 2005;90:3680-7 pubmed
    ..This pathway appears to be impaired in PE and may contribute toward dysregulation of the balance controlling vascular resistance. ..
  60. Briggs F, Bartlett S, Goldstein B, Wang J, McCauley J, Zuvich R, et al. Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals. Hum Mol Genet. 2010;19:4286-95 pubmed publisher
    ..algorithm, identified eight intronic SNPs within the corticotrophin-releasing hormone receptor 1 or CRHR1 locus on 17q21.31 as important predictors of MS...
  61. Bogdan R, Santesso D, Fagerness J, Perlis R, Pizzagalli D. Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning. J Neurosci. 2011;31:13246-54 pubmed publisher
    ..emerging data indicate that genetic variation within the corticotropin-releasing hormone type 1 receptor gene (CRHR1) at rs12938031 may promote psychopathology, particularly in the context of stress...
  62. Simón Sánchez J, Schulte C, Bras J, Sharma M, Gibbs J, Berg D, et al. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet. 2009;41:1308-12 pubmed publisher
    ..14, P = 1.55 x 10(-5)). These data demonstrate an unequivocal role for common genetic variants in the etiology of typical PD and suggest population-specific genetic heterogeneity in this disease. ..
  63. Martín Blanco A, Ferrer M, Soler J, Arranz M, Vega D, Calvo N, et al. The role of hypothalamus-pituitary-adrenal genes and childhood trauma in borderline personality disorder. Eur Arch Psychiatry Clin Neurosci. 2016;266:307-16 pubmed publisher
    ..There were also associations between BPD and haplotype combinations of the genes FKBP5 and CRHR1. Two FKBP5 alleles (rs3798347-T and rs10947563-A) were more frequent in BPD subjects with history of physical ..
  64. Pilbrow A, Lewis K, Perrin M, Sweet W, Moravec C, Tang W, et al. Cardiac CRFR1 Expression Is Elevated in Human Heart Failure and Modulated by Genetic Variation and Alternative Splicing. Endocrinology. 2016;157:4865-4874 pubmed
    ..factor (CRF) and the CRF-related peptides, urocortin (Ucn)-1, Ucn2, and Ucn3 signal through receptors CRFR1 and CRFR2 to restore homeostasis in response to stress...
  65. Ben Efraim Y, Wasserman D, Wasserman J, Sokolowski M. Gene-environment interactions between CRHR1 variants and physical assault in suicide attempts. Genes Brain Behav. 2011;10:663-72 pubmed publisher
    ..of SLE exposures with single nucleotide polymorphisms (SNPs) in corticotropin-releasing hormone receptor-1 (CRHR1), a major HPA axis regulatory gene...
  66. Briffa J, Hosseini S, Tran M, Moritz K, Cuffe J, Wlodek M. Maternal growth restriction and stress exposure in rats differentially alters expression of components of the placental glucocorticoid barrier and nutrient transporters. Placenta. 2017;59:30-38 pubmed publisher
    ..Maternal stress decreased the expression of Slc2a1, Igf2, Slc38a2, Nr3c1, Slc2a3, Slc2a4, Nr3c2, Hsd11b2, Crhr1 and Ogt...
  67. Yang G, Zou L, Wang J, Shi X, Yang X, Wang B, et al. Association analysis of polymorphisms of the CRHR1 gene with infantile spasms. Mol Med Rep. 2015;12:2539-46 pubmed publisher
    ..To test the genetic association between the CRHR1 gene, which encodes the corticotrophin-releasing hormone (CRH) receptor, and infantile spasms, five single ..
  68. Qi X, Guzhva L, Yang Z, Febo M, Shan Z, Wang K, et al. Overexpression of CRF in the BNST diminishes dysphoria but not anxiety-like behavior in nicotine withdrawing rats. Eur Neuropsychopharmacol. 2016;26:1378-1389 pubmed publisher
    ..The overexpression of CRF increased CRF1 and CRF2 receptor gene expression and increased the CRF2/CRF1 receptor ratio...
  69. Doré A, Bortolato A, Hollenstein K, Cheng R, Read R, Marshall F. Decoding Corticotropin-Releasing Factor Receptor Type 1 Crystal Structures. Curr Mol Pharmacol. 2017;10:334-344 pubmed publisher
  70. Strege A, Carpenter B, Edwards P, Tate C. Strategy for the Thermostabilization of an Agonist-Bound GPCR Coupled to a G Protein. Methods Enzymol. 2017;594:243-264 pubmed publisher