CRH

Summary

Gene Symbol: CRH
Description: corticotropin releasing hormone
Alias: CRF, corticoliberin, corticotropin-releasing factor
Species: human

Top Publications

  1. ncbi Distribution and quantification of corticotropin-releasing hormone (CRH) in the brain of the teleost fish Oreochromis mossambicus (tilapia)
    Peter P L M Pepels
    Department of Animal Physiology, Faculty of Science, University of Nijmegen, 6525 ED Nijmegen, The Netherlands
    J Comp Neurol 453:247-68. 2002
  2. ncbi Modulation of corticotropin-releasing hormone receptor type 2 mRNA expression by CRH deficiency or stress in the mouse heart
    Hossein Pournajafi Nazarloo
    Second Department of Internal Medicine, Kochi Medical School, Kohasu, Okoh cho, Nankoku 783 8505, Japan
    Regul Pept 115:131-8. 2003
  3. ncbi Corticotropin-releasing hormone in the teleost stress response: rapid appearance of the peptide in plasma of tilapia (Oreochromis mossambicus)
    P P L M Pepels
    Department of Animal Physiology, Faculty of Sciences, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    J Endocrinol 180:425-38. 2004
  4. ncbi Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1
    P Timpl
    Max Planck Institute of Psychiatry, Munich, Germany
    Nat Genet 19:162-6. 1998
  5. doi Differential regulation of glucose transporters mediated by CRH receptor type 1 and type 2 in human placental trophoblasts
    Lu Gao
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China
    Endocrinology 153:1464-71. 2012
  6. pmc Angiotensin II type 1 receptor signaling regulates feeding behavior through anorexigenic corticotropin-releasing hormone in hypothalamus
    Rie Yamamoto
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Chiba 260 8670, Japan
    J Biol Chem 286:21458-65. 2011
  7. ncbi A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes
    D K Grammatopoulos
    Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Coventry, United Kingdom
    Mol Endocrinol 13:2189-202. 1999
  8. ncbi The expression of corticotropin-releasing hormone in melanoma
    Hirofumi Sato
    Department of Dermatology, Kobe University School of Medicine, Japan
    Pigment Cell Res 15:98-103. 2002
  9. ncbi Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term
    B Wetzka
    Dept of Obstetrics and Gynecology, University of Freiburg, Freiburg, Germany
    Exp Clin Endocrinol Diabetes 111:154-61. 2003
  10. ncbi Placental stress factors and maternal-fetal adaptive response: the corticotropin-releasing factor family
    Pasquale Florio
    Chair of Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
    Endocrine 19:91-102. 2002

Research Grants

  1. Effects of early-life experience:role of CRH
    TALLIE Z Z BARAM; Fiscal Year: 2010
  2. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
  3. Neural Analysis of Maternal Aggression
    STEPHEN GAMMIE; Fiscal Year: 2006
  4. CRH-MRNA REGULATION-- ROLE IN NEONATAL SEIZURE POTENTIAL
    Tallie Z Baram; Fiscal Year: 2003
  5. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
  6. Stress Induces Skin Mast Cell Activation & Vasodilation
    Theoharis Theoharides; Fiscal Year: 2005
  7. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2004
  8. CRH Receptors and Stress Response Pathways
    Mary Stenzel Poore; Fiscal Year: 2007
  9. GR-Mediated Epigenetic Regulation of the CRH Gene
    ROSALIE MARIE UHT; Fiscal Year: 2010
  10. GR-Mediated Epigenetic Regulation of the CRH Gene
    ROSALIE UHT; Fiscal Year: 2009

Detail Information

Publications233 found, 100 shown here

  1. ncbi Distribution and quantification of corticotropin-releasing hormone (CRH) in the brain of the teleost fish Oreochromis mossambicus (tilapia)
    Peter P L M Pepels
    Department of Animal Physiology, Faculty of Science, University of Nijmegen, 6525 ED Nijmegen, The Netherlands
    J Comp Neurol 453:247-68. 2002
    The recent characterization of the corticotropin-releasing hormone (CRH) prehormone of the fish tilapia (Oreochromis mossambicus) showed that more variation exists between vertebrate CRH amino acid sequences than recognized before...
  2. ncbi Modulation of corticotropin-releasing hormone receptor type 2 mRNA expression by CRH deficiency or stress in the mouse heart
    Hossein Pournajafi Nazarloo
    Second Department of Internal Medicine, Kochi Medical School, Kohasu, Okoh cho, Nankoku 783 8505, Japan
    Regul Pept 115:131-8. 2003
    The actions of corticotropin-releasing hormone (CRH) and the related peptides are coordinated by two receptors, CRH receptor type 1 (CRH-R1) and CRH receptor type 2 (CRH-R2)...
  3. ncbi Corticotropin-releasing hormone in the teleost stress response: rapid appearance of the peptide in plasma of tilapia (Oreochromis mossambicus)
    P P L M Pepels
    Department of Animal Physiology, Faculty of Sciences, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    J Endocrinol 180:425-38. 2004
    High concentrations (up to 600 pg/ml) of corticotropin-releasing hormone (CRH) were detected in plasma of the teleost fish Oreochromis mossambicus (tilapia) when screening peripheral tissues of tilapia exposed to stress...
  4. ncbi Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1
    P Timpl
    Max Planck Institute of Psychiatry, Munich, Germany
    Nat Genet 19:162-6. 1998
    Corticotropin-releasing hormone (CRH) is a potent mediator of endocrine, autonomic, behavioural and immune responses to stress, and has been implicated in the stress-like and other aversive consequences of drug abuse, such as withdrawal ..
  5. doi Differential regulation of glucose transporters mediated by CRH receptor type 1 and type 2 in human placental trophoblasts
    Lu Gao
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China
    Endocrinology 153:1464-71. 2012
    ..Regulatory mechanisms of GLUT in placenta have not been elucidated. Placental CRH has been implicated to play a key role in the control of fetal growth and development...
  6. pmc Angiotensin II type 1 receptor signaling regulates feeding behavior through anorexigenic corticotropin-releasing hormone in hypothalamus
    Rie Yamamoto
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Chiba 260 8670, Japan
    J Biol Chem 286:21458-65. 2011
    ..In the hypothalamus, mRNA levels of anorexigenic neuropeptide corticotropin-releasing hormone (Crh) were lower in Agtr1a(-/-) mice than in Agtr1a(+/+) mice both on an ad libitum and pair-fed diet...
  7. ncbi A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes
    D K Grammatopoulos
    Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Coventry, United Kingdom
    Mol Endocrinol 13:2189-202. 1999
    b>CRH exerts its actions via activation of specific G protein-coupled receptors, which exist in two types, CRH-R1 and CRH-R2, and arise from different genes with multiple spliced variants...
  8. ncbi The expression of corticotropin-releasing hormone in melanoma
    Hirofumi Sato
    Department of Dermatology, Kobe University School of Medicine, Japan
    Pigment Cell Res 15:98-103. 2002
    ..whether the high expression of POMC derives from increased expression of corticotropin-releasing hormone (CRH) and the possible role of CRH as a melanoma growth factor...
  9. ncbi Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term
    B Wetzka
    Dept of Obstetrics and Gynecology, University of Freiburg, Freiburg, Germany
    Exp Clin Endocrinol Diabetes 111:154-61. 2003
    Recent research suggests a significant role for placental corticotropin-releasing hormone (CRH) in controlling human parturition...
  10. ncbi Placental stress factors and maternal-fetal adaptive response: the corticotropin-releasing factor family
    Pasquale Florio
    Chair of Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
    Endocrine 19:91-102. 2002
    ..Among these factors, corticotropin-releasing factor (CRF) has been one of the more investigated in the last decade...
  11. ncbi A placental clock controlling the length of human pregnancy
    M McLean
    Maternal Health Research Centre, John Hunter Hospital, Newcastle, NSW, Australia
    Nat Med 1:460-3. 1995
    ..study of 485 pregnant women we have demonstrated that placental secretion of corticotropin-releasing hormone (CRH) is a marker of this process and that measurement of the maternal plasma CRH concentration as early as 16-20 weeks ..
  12. pmc CRH functions as a growth factor/cytokine in the skin
    A Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Cell Physiol 206:780-91. 2006
    We tested the effect of CRH and related peptides in a large panel of human skin cells for growth factor/cytokine activities...
  13. ncbi The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden
    Stephan Claes
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Belgium
    Biol Psychiatry 54:867-72. 2003
    ..Therefore, the gene encoding for corticotropin releasing hormone binding protein is a functional candidate gene for major depression...
  14. ncbi mRNA expression profiles for corticotrophin-releasing hormone, urocortin, CRH-binding protein and CRH receptors in human term gestational tissues determined by real-time quantitative RT-PCR
    B Sehringer
    Department of Obstetrics and Gynaecology, Endocrinology Laboratory, University of Freiburg, Hugstetter Str 55, D 79106 Freiburg, Germany
    J Mol Endocrinol 32:339-48. 2004
    Increasing maternal plasma levels of corticotrophin-releasing hormone (CRH) during the last weeks of pregnancy suggest that this stress hormone plays an important role in the control of human parturition...
  15. doi Estrogen receptor-alpha and -beta regulate the human corticotropin-releasing hormone gene through similar pathways
    Xiao Ning Chen
    Department of Neurobiology, School of Life Science, University of Science and Technology of China, Hefei, Anhui, People s Republic of China
    Brain Res 1223:1-10. 2008
    Corticotropin-releasing hormone (CRH) plays a central role in controlling stress response. In this study, we aimed to identify the regulatory effect of estrogen receptor (ER) on CRH and the underlying mechanism...
  16. pmc Up-regulation of nitric oxide synthase and modulation of the guanylate cyclase activity by corticotropin-releasing hormone but not urocortin II or urocortin III in cultured human pregnant myometrial cells
    Eleni Aggelidou
    Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Proc Natl Acad Sci U S A 99:3300-5. 2002
    The biological actions of corticotropin-releasing hormone (CRH) in the human myometrium during pregnancy and labor are unknown...
  17. ncbi Corticotropin-releasing hormone-binding protein and its possible role in neuroendocrinological research
    X J Zhao
    Department of Internal Medicine I, University of Leipzig, Germany
    Horm Metab Res 29:373-8. 1997
    Corticotropin-releasing hormone-binding protein (CRH-BP), predominately produced by the liver, is a glycoprotein with a molecular weight of 37 kDa...
  18. ncbi Pituitary gland: neuropeptides, neurotransmitters and growth factors
    J I Koenig
    Neurology Service, Massachusetts General Hospital, Boston
    Toxicol Pathol 17:256-65. 1989
    ..These effects appear to be mediated by changes in the secretion of the corticotropin-releasing hormone (CRH) and vasopressin into the hypophyseal portal circulation...
  19. ncbi Involvement of stress in the sleep rebound mechanism induced by sleep deprivation in the rat: use of alpha-helical CRH (9-41)
    M M Gonzalez
    Departement de Medecine Experimentale, INSERM U480, Faculte de Medecine, Universite Claude Bernard, Lyon, France
    Behav Pharmacol 9:655-62. 1998
    A previous study demonstrated the efficacy of the corticotropin-releasing hormone (CRH) receptor antagonist, alpha-helical CRH (9-41), in blocking the paradoxical sleep increase induced by stress...
  20. ncbi Expression of the corticotropin-releasing hormone (CRH) gene in human placenta and amniotic membrane
    E Okamoto
    Department of Obstetrics and Gynecology, Osaka University Medical School, Japan
    Horm Metab Res 22:394-7. 1990
    Immunoreactive corticotropin-releasing hormone (IR-CRH) in maternal plasma increases progressively during pregnancy and decreases rapidly after delivery, suggesting that IR-CRH is produced in the placenta...
  21. ncbi Neuropeptides and human sleep
    A Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    Sleep 20:1038-52. 1997
    ..the balance between the neuropeptides growth hormone-releasing hormone (GHRH) and corticotropin-releasing hormone (CRH) plays a key role in normal and pathological sleep regulation...
  22. ncbi Procaine and lidocaine stimulate corticotropin-releasing hormone secretion by explanted rat hypothalami through a sodium conductance-independent mechanism
    A E Calogero
    Developmental Endocrinology Branch, National Institute of Child Health and Human Developmental, National Institute of Mental Health, Bethesda, Maryland
    Horm Metab Res 22:25-8. 1990
    We have previously shown that procaine and lidocaine stimulate corticotropin-releasing hormone (CRH) secretion by explanted rat hypothalami...
  23. ncbi [Studies on the influence of releasing hormones TRH and CRH on respiratory regulation]
    M Nink
    III. Medizinische Klinik und Poliklinik, Innere Medizin,
    Pneumologie 45:246-8. 1991
    Patterns of neuroanatomical distribution of Thyrotropin-releasing hormone (TRH) and Corticotropin-releasing hormone (CRH) and of their receptors in brain areas of humans and of animals suppose a regulating function of both peptides on ..
  24. ncbi Brain evoked responses, a bioassay for central actions of adrenocorticotropin (ACTH 1-39) and corticotropin releasing hormone (CRH) in humans
    J Born
    , , Germany
    Horm Metab Res 23:126-30. 1991
    ..are part of a series of studies which have been conducted to demonstrate the afferent influences of ACTH and CRH on brain activity by recording of auditory event-related brain potentials (ERPs) in healthy human subjects...
  25. ncbi The stress-, but not corticotropin-releasing hormone-induced activation of the pituitary-adrenal axis in man is blocked by alprazolam
    T Rohrer
    III. Medizinische Klinik, Innere Medizin-Endokrinologie, , Germany
    Horm Metab Res 26:200-6. 1994
    A number of experimental studies clearly suggest that benzodiazepines attenuate the corticotropin-releasing hormone (CRH) secretion possibly through inhibitory GABAergic neurons...
  26. ncbi Immunoreactive corticotropin-releasing hormone, adrenocorticotropin and cortisol in human plasma during pregnancy and delivery and postpartum
    E Okamoto
    Department of Obstetrics and Gynecology, Osaka University Medical School, Japan
    Horm Metab Res 21:566-72. 1989
    ..adrenal axis was examined, by measuring the levels of immunoreactive (IR) corticotropin-releasing hormone (CRH), adrenocorticotropin (ACTH) and cortisol (F) in human plasma during normal pregnancy and after delivery with or ..
  27. ncbi Does estradiol treatment normalize the hypothalamic-pituitary-adrenal axis in streptozotocin-induced ovariectomized diabetic female rats?
    K E Elkind-Hirsch
    Department of Medicine, Methodist Hospital, Houston, Texas
    Horm Metab Res 23:481-5. 1991
    ..It was the purpose of this study to evaluate basal and corticotropin releasing hormone (CRH)-stimulated CS secretion in ovariectomized (OVX) control (C) and streptozotocin-induced diabetic (D) rats given ..
  28. ncbi Interleukin-1 potentiates basal and AVP-stimulated ACTH secretion in vitro--the role of CRH pre-incubation
    W J Inder
    Department of Endocrinology, Christchurch Hospital, New Zealand
    Horm Metab Res 32:350-4. 2000
    ..IL-1) is known to activate the hypothalamic pituitary adrenal axis, primarily via corticotropin releasing hormone (CRH)...
  29. ncbi CRH and lysine-vasopressin stimulation tests in the diagnosis of hypoadrenalism secondary to hypothalamic or pituitary disorders
    L Cantalamessa
    Semeiotica Medica I, , Ospedale Maggiore, Italy
    Horm Metab Res 22:389-93. 1990
    Ten patients with secondary hypoadrenalism have been tested with corticotropin releasing hormone (CRH) and lysine-vasopressin (LVP)...
  30. ncbi Antisense oligodeoxynucleotides for in vivo targeting of corticotropin-releasing hormone mRNA: comparison of phosphorothioate and 3'-inverted probe performance
    T Skutella
    Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany
    Horm Metab Res 26:460-4. 1994
    ..An attempt was made to establish an animal model of reduced corticotropin-releasing hormone (CRH) activity, using antisense DNA corresponding to the start coding region of rat CRH mRNA with either 3'-3' inverted ..
  31. ncbi Role of prostaglandin E2 (PGE2) on the corticotropin-releasing hormone (CRH)-induced ACTH release in healthy men
    S Zacharieva
    Institute of Endocrinology and Gerontology, Medical Academy, Sofia, Bulgaria
    Horm Metab Res 24:336-8. 1992
    The effect of PGE2 on ACTH and cortisol responses to CRH was studied in 6 healthy men who received CRH i.v. during either saline or PGE2 infusions which were started 60 min. before testing...
  32. ncbi Detection of corticotropin-releasing hormone receptor 1 immunoreactivity in cholinergic, dopaminergic and noradrenergic neurons of the murine basal forebrain and brainstem nuclei--potential implication for arousal and attention
    M Sauvage
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804, Munich, Germany
    Neuroscience 104:643-52. 2001
    Corticotropin-releasing hormone (CRH) interacts with noradrenergic, dopaminergic and cholinergic systems of the brain, and these interactions are thought to be of relevance for the stress response, anxiety-related behavior, and cognitive ..
  33. ncbi Maternal and fetal hypothalamic-pituitary-adrenal axes during pregnancy and postpartum
    George Mastorakos
    2nd Department of Obstetrics and Gynecology, Medical School, University of Athens, Aretaieion Hospital, Athens, Greece
    Ann N Y Acad Sci 997:136-49. 2003
    The principal modulators of the hypothalamic-pituitary-adrenal (HPA) axis are corticotropin-releasing hormone (CRH) and arginine-vasopressin (AVP). Corticotropin-releasing hormone is not exclusively produced in the hypothalamus...
  34. ncbi [Expression and roles of corticotropin-releasing hormone, cortisol and dehydroepiandrosterone sulfate in preterm labour]
    Yi ling Ding
    Department of Obstetrics and Gynecology, Xiangya Second Hospital, Central South University, Changsha 410011, China
    Zhonghua Fu Chan Ke Za Zhi 42:239-43. 2007
    To investigate the effect of corticotropin-releasing hormone (CRH), cortisol and dehydroepiandrosterone sulfate in pathogenesis of preterm labor.
  35. pmc Infantile spasms: hypothesis-driven therapy and pilot human infant experiments using corticotropin-releasing hormone receptor antagonists
    T Z Baram
    Department of Anatomy Neurobiology, University of California at Irvine, CA 92697 4475, USA
    Dev Neurosci 21:281-9. 1999
    ..involving suppression of the age-specific endogenous convulsant neuropeptide corticotropin-releasing hormone (CRH)...
  36. ncbi Corticotropin-releasing hormone (CRH) expression and protein kinase A mediated CRH receptor signalling in an immortalized hypothalamic cell line
    J Kasckow
    Cincinnati VAMC, Psychiatry Service 116A, and School of Medicine, Department of Psychiatry, and Neurosciences Program, University of Cincinnati, OH 45267 0559, USA
    J Neuroendocrinol 15:521-9. 2003
    Corticotropin-releasing hormone (CRH) is a 41 amino acid neuropeptide which plays an important role in the stress response in the hypothalamus. We describe the development of an immortalized hypothalamic cell line which expresses CRH...
  37. ncbi Antipsychotic drugs inhibit the human corticotropin-releasing-hormone gene promoter activity in neuro-2A cells-an involvement of protein kinases
    Agnieszka Basta-Kaim
    Laboratory of Immunoendocrinology, Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Neuropsychopharmacology 31:853-65. 2006
    ..However, molecular mechanism of antipsychotic drug action on the corticotropin-releasing hormone (CRH) gene activity has not been investigated so far...
  38. ncbi Redistribution of corticotropin-releasing hormone receptor R2 using fluorescence immunohistochemistry in fetal membranes of women delivering preterm or at term
    Stefan Jirecek
    Department of Obstetrics and Gynecology, University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 114:1008-12. 2002
    ..study was to determine whether a difference exists in expression of corticotropin-releasing hormone receptor-R1 (CRH-R1) and corticotropin-releasing hormone receptor-R2 (CRH-R2) in fetal membranes of preterm and term women with or ..
  39. ncbi Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation
    Shin Fukudo
    Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2 1 Seiryo, Aoba, Sendai, 980 8575, Japan
    J Gastroenterol 42:48-51. 2007
    Corticotropin-releasing hormone (CRH) is a major mediator of stress response in the brain-gut axis. Irritable bowel syndrome (IBS) is presumed to be a disorder of the brain-gut link associated with exaggerated response to stress...
  40. ncbi Involvement of corticotropin-releasing hormone receptor subtypes 1 and 2 in peripheral opioid-mediated inhibition of inflammatory pain
    Shaaban A Mousa
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Hindenburgdamm 30, D 12200, Berlin, Germany
    Pain 106:297-307. 2003
    In painful inflammation, exogenous as well as endogenous corticotropin-releasing hormone (CRH) can release opioid peptides (mainly beta-endorphin) from various types of immune cells and produce antinociception by activating opioid ..
  41. pmc Corticotropin-releasing hormone (CRH) downregulates the function of its receptor (CRF1) and induces CRF1 expression in hippocampal and cortical regions of the immature rat brain
    Kristen L Brunson
    Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697, USA
    Exp Neurol 176:75-86. 2002
    In addition to regulating the neuroendocrine stress response, corticotropin-releasing hormone (CRH) has been implicated in both normal and pathological behavioral and cognitive responses to stress...
  42. ncbi Expression of corticotropin-releasing hormone receptor type 1 and type 2 in human pregnant myometrium
    Dan Jin
    Department of Obstetrics and Gynecology, Changhai Hospital, Shanghai, PR China
    Reprod Sci 14:568-77. 2007
    It has been suggested that corticotropin-releasing hormone (CRH) receptors CRH-R1 and CRH-R2 might be involved in the modulation of uterine activity during pregnancy...
  43. pmc Central deficiency of corticotropin-releasing hormone receptor type 1 (CRH-R1) abolishes effects of CRH on NREM but not on REM sleep in mice
    Christoph P N Romanowski
    Max Planck Institute of Psychiatry, Munich, Germany
    Sleep 33:427-36. 2010
    Corticotropin-releasing hormone (CRH) is the major activator of the hypothalamic-pituitary-adrenocortical (HPA) system and orchestrates the neuroendocrine, autonomous as well as behavioral responses to stress...
  44. ncbi Functional expression of corticotropin-releasing hormone (CRH) receptor 1 in cultured rat microglia
    Wei Wang
    Department of Pediatrics, Kingston General Hospital, Ontario, Canada
    J Neurochem 80:287-94. 2002
    Corticotropin-releasing hormone (CRH), known as a key regulator of the hypothalamic-pituitary-adrenal axis response to stress, elicits its biological effects by binding to two membrane receptors (CRH-R1 and CRH-R2)...
  45. ncbi Placental corticotropin-releasing hormone (CRH), spontaneous preterm birth, and fetal growth restriction: a prospective investigation
    Pathik D Wadhwa
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697 4260, USA
    Am J Obstet Gynecol 191:1063-9. 2004
    Recent advances in the physiology of human pregnancy have implicated placental corticotropin-releasing hormone (CRH) as one of the primary endocrine mediators of parturition and possibly also of fetal development...
  46. ncbi The stress system in the human brain in depression and neurodegeneration
    Dick F Swaab
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    Ageing Res Rev 4:141-94. 2005
    Corticotropin-releasing hormone (CRH) plays a central role in the regulation of the hypothalamic-pituitary-adrenal (HPA)-axis, i.e., the final common pathway in the stress response...
  47. pmc Levels of maternal serum corticotropin-releasing hormone (CRH) at midpregnancy in relation to maternal characteristics
    Yumin Chen
    Department of Epidemiology, Michigan State University, East Lansing, MI 48824, USA
    Psychoneuroendocrinology 35:820-32. 2010
    Corticotropin-releasing hormone (CRH) in maternal blood originates primarily from gestational tissues and elevated levels in midpregnancy have been linked to adverse pregnancy outcomes...
  48. pmc Synaptic physiology of central CRH system
    Joel P Gallagher
    University of Texas Medical Branch, Department of Pharmacology and Toxicology Galveston, TX 77555 1031 USA
    Eur J Pharmacol 583:215-25. 2008
    Corticotropin-Releasing Hormone (CRH) or Corticotropin-Releasing Factor (CRF) and its family of related naturally occurring endogenous peptides and receptors are becoming recognized for their actions within central (CNS) and peripheral (..
  49. ncbi Corticotropin-releasing hormone stimulation following low-dose dexamethasone administration. A new test to distinguish Cushing's syndrome from pseudo-Cushing's states
    J A Yanovski
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    JAMA 269:2232-8. 1993
    ..Both dexamethasone suppression and corticotropin-releasing hormone (CRH) stimulation tests have been used individually to distinguish these conditions, but neither approach has achieved a ..
  50. ncbi The stress system in depression and neurodegeneration: focus on the human hypothalamus
    A M Bao
    Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
    Brain Res Rev 57:531-53. 2008
    ..Activity of the corticotropin-releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN) forms the basis of the activity of the HPA-axis...
  51. pmc Mouse strain differences in the effects of corticotropin releasing hormone (CRH) on sleep and wakefulness
    L D Sanford
    Sleep Research Laboratory, Department of Pathology and Anatomy, Eastern Virginia Medical School, USA
    Brain Res 1190:94-104. 2008
    Corticotropin releasing hormone (CRH) plays a major role in central nervous system responses to stressors and has been implicated in stress-induced alterations in sleep...
  52. doi Role of corticotropin-releasing hormone and receptor in the pathogenesis of psoriasis
    Chunlei Zhou
    Department of Dermatology, Qilu Hospital of Shandong University, Jinan 250012, PR China
    Med Hypotheses 73:513-5. 2009
    ..Corticotrophin-releasing hormone (CRH) is a central component of the hypothalamic-pituitary-adrenal (HPA) axis and is an important coordinator of the ..
  53. ncbi D-amino acid-substituted analogs of corticotropin-releasing hormone (CRH) and urocortin with selective agonist activity at CRH1 and CRH2beta receptors
    E T Wei
    School of Public Health, University of California, Berkeley 94720, USA
    Peptides 19:1183-90. 1998
    The activities of corticotropin-releasing hormone (CRH)-related peptides and several analogs were examined in cells transfected with either CRH1 or CRH2beta receptors, in suppression of heat-induced rat paw edema in pentobarbital-..
  54. ncbi Differential release of corticotropin-releasing hormone (CRH) in the amygdala during different types of stressors
    Gregory A Hand
    Department of Exercise Science, University of South Carolina, 1300 Wheat St, Columbia, SC 29208, USA
    Brain Res 949:122-30. 2002
    ..exist between the effects of acute treadmill running and restraint stress on corticotropin-releasing hormone (CRH) release within the amygdala of rats...
  55. ncbi Central activation of thermogenesis by prostaglandins: dependence on CRF
    N J Rothwell
    Department of Physiological Sciences, University of Manchester, United Kingdom
    Horm Metab Res 22:616-8. 1990
    ..The effects of combined injection of maximal doses of CRF and PGE2 were additive, whereas PGF2 alpha and CRF were not...
  56. ncbi Oreochromis mossambicus (tilapia) corticotropin-releasing hormone: cDNA sequence and bioactivity
    F H van Enckevort
    Department of Animal Physiology, Faculty of Science, University of Nijmegen, Toernooiveld, Nijmegen, The Netherlands
    J Neuroendocrinol 12:177-86. 2000
    Although hypothalamic corticotropin-releasing hormone (CRH) is involved in the stress response in all vertebrate groups, only a limited number of studies on this neuroendocrine peptide deals with non-mammalian neuroendocrine systems...
  57. pmc CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques
    Christina S Barr
    Laboratory of Clinical Studies, Primate Section, National Institute on Alcohol Abuse Alcoholism, Division of Intramural Clinical and Biological Research, TR 112, PO Box 529, Poolesville, MD 20837, USA
    Arch Gen Psychiatry 65:934-44. 2008
    ..in stress reactivity, exploration, and response to novelty have been attributed to differences in corticotropin-releasing hormone (CRH) system function. As such, CRH gene variation may influence risk for alcohol use and dependence.
  58. ncbi Immunoautoradiographic and in situ hybridization analysis of corticotropin-releasing hormone biosynthesis in the hypothalamic paraventricular nucleus
    J P Herman
    Department of Anatomy and Neurobiology, University of Kentucky School of Medicine, Lexington 40536 0084, USA
    J Chem Neuroanat 11:49-56. 1996
    Corticotropin-releasing hormone (CRH) gene transcription and mRNA expression are keyed to stimuli activating the pituitary-adrenocortical axis, suggesting a connection between neuronal activation and synthesis of active peptide...
  59. ncbi Corticotropin-releasing hormone skin signaling is receptor-mediated and is predominant in the sebaceous glands
    K Krause
    Department of Dermatology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Horm Metab Res 39:166-70. 2007
    ..However, CRH had no effect on interleukin-1alpha and interleukin-1beta production in these cells. alpha-Helical-CRF, a CRH antagonistic peptide, annulled the CRH effect on SZ95 sebocyte proliferation and interleukin secretion, ..
  60. ncbi Effects of chronic cocaine exposure on corticotropin-releasing hormone binding protein in the central nucleus of the amygdala and bed nucleus of the stria terminalis
    S Erb
    Centre for the Neurobiology of Stress, Department of Life Science and Psychology, University of Toronto at Scarborough, 1265 Military Trail, Scarborough, Ontario M1C 1A4, Canada
    Neuroscience 123:1003-9. 2004
    The neuropeptide, corticotropin-releasing hormone (CRH), has been shown to play a role in behavioral and neurobiological effects of drugs of abuse...
  61. doi Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions
    S Silberstein
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiología y Biología y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and IFIBYNE CONICET, Ciudad Universitaria, Buenos Aires, Argenita
    Neuroscience 159:610-7. 2009
    Corticotropin-releasing hormone (CRH) coordinates neuroendocrine and behavioral adaptations to stress...
  62. ncbi Bombesin and ceruletide-induced grooming and inhibition of ingestion in the rat
    P J Kulkosky
    Department of Psychology, University of Southern Colorado, Pueblo 81001
    Ann N Y Acad Sci 525:201-18. 1988
    ..exhibits short-term cross-tolerance with ACTH in elicitation of grooming, and central CCK-8 is co-localized with CRF and stimulates ACTH and corticosterone release in the rat...
  63. pmc Stimulation of the hypothalamo-pituitary-adrenal axis in the rat by three selective type-4 phosphodiesterase inhibitors: in vitro and in vivo studies
    M Kumari
    Department of Pharmacology, Charing Cross and Westminister Medical School, London
    Br J Pharmacol 121:459-68. 1997
    ..001) and BRL 61063 (1 and 10 microM, P < 0.05) stimulated the release of corticotrophin releasing hormone (ir-CRH-41) but lower concentrations of the drugs were without effect as also was BRL 61063 at 100 microM (P > 0...
  64. pmc High-affinity uptake of noradrenaline in postsynaptic neurones
    S al Damluji
    Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, MD 20892
    Br J Pharmacol 109:299-307. 1993
    ..isomer 6-hydroxydopamine was used, suggested that the post synaptic uptake process is operative in hypothalamic CRH and vasopressin neurones in vivo.11...
  65. ncbi Neuroendocrinology of the pituitary gland
    S Reichlin
    Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts 02111
    Toxicol Pathol 17:250-5. 1989
    ..Specific neuropeptides have been isolated which stimulate the secretion of ACTH (CRF, corticotrophin releasing hormone), TSH (TRH, thyrotropin releasing hormone), GH (GHRH, growth hormone releasing ..
  66. ncbi Corticotropin-releasing factor induces phosphorylation of phospholipase C-gamma at tyrosine residues via its receptor 2beta in human epidermoid A-431 cells
    J G Kiang
    Department of Clinical Physiology, Division of Medicine, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
    Eur J Pharmacol 363:203-10. 1998
    This laboratory previously reported that corticotropin-releasing factor (CRF) increased intracellular free calcium concentrations, cellular cAMP, inositol 1,4,5-trisphosphate, protein kinase C activity, and protein phosphorylation in ..
  67. ncbi Changes in physiological and neuroendocrine properties during thermal adaptation of golden hamsters (Mesocricetus auratus)
    J Roth
    Physiologisches Institut, Giessen, Federal Republic of Germany
    J Comp Physiol B 160:153-9. 1990
    ..hamsters the brains were processed for immunocytochemical detection of arginine-vasopressin (AVP) and corticotropin releasing factor (CRF) in the third week of adaptation to a cold or warm environment...
  68. ncbi Aberrant production and regulation of proopiomelanocortin-derived peptides in ectopic Cushing's syndrome
    K A Roth
    Department of Pathology, Washington University School of Medicine, St. Louis, Missouri
    Horm Metab Res 20:225-9. 1988
    ..In dispersed monolayer culture, CRF failed to elicit ACTH release from the tumor cells, but dexamethasone caused a paradoxical increase in ACTH ..
  69. ncbi Corticotropin-releasing factor receptor expression in the pituitary of fetal sheep after lesion of the hypothalamic paraventricular nucleus
    D A Myers
    Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    Endocrinology 140:4292-9. 1999
    Both the capacity of CRF to release ACTH and the number of binding sites for CRF in the anterior pituitary decline during the final weeks of gestation in fetal sheep...
  70. ncbi A role for corticotropin releasing factor and urocortin in behavioral responses to stressors
    G F Koob
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Brain Res 848:141-52. 1999
    Corticotropin-releasing factor (CRF) and CRF-related neuropeptides have an important role in the central nervous system to mediate behavioral responses to stressors...
  71. ncbi Dopamine-dependent responses to cocaine depend on corticotropin-releasing factor receptor subtypes
    Lin Lu
    Institute of Mental Health, West China University of Medical Sciences, Chengdu, China Medical Center of Fudan University, Shanghai, China
    J Neurochem 84:1378-86. 2003
    ..DA) release in nucleus accumbens and ventral tegmental area by the non-specific corticotropin-releasing factor (CRF) receptors antagonist alpha-helical CRF, the selective CRF receptor subtype 1 antagonist CP-154,526 and the ..
  72. ncbi Characterization of the effects of corticotropin-releasing factor on prepulse inhibition of the acoustic startle response in Brown Norway and Wistar-Kyoto rats
    Lisa H Conti
    Department of Psychiatry, MC 1410, University of Connecticut Health Center, Farmington, CT 06030, USA
    Eur J Pharmacol 507:125-34. 2005
    ..prepulse inhibition is decreased by central administration of the neuropeptide, corticotropin-releasing factor (CRF) in both strains...
  73. ncbi Effects of corticotropin-releasing factor on prepulse inhibition of the acoustic startle response in two rat strains
    Lisa H Conti
    Department of Pharmacology, 0636, University of California, San Diego, 9500 Gilman Drive, La Jolla 92093, USA
    Psychopharmacology (Berl) 161:296-303. 2002
    ..Corticotropin-releasing factor (CRF), a neurotransmitter that is released during stress, and CRF receptors are expressed in areas of the brain which ..
  74. ncbi [Relationship between the central renin-angiotensin system, stress and hypertension]
    E C Dumont
    Centre de Recherche du CHUL, , , Canada
    Arch Mal Coeur Vaiss 92:1111-3. 1999
    ..Among the central neurochemical systems, CRF and the renin-angiotensin may represent major modulatory systems involved in the adaptation of an organism to ..
  75. pmc Relaxing actions of corticotropin-releasing factor on rat resistance arteries
    S Lei
    Danish Biomembrane Research Centre, Aarhus University
    Br J Pharmacol 108:941-7. 1993
    1. Although it well established that corticotropin-releasing factor (CRF) injected i.v. can cause hypotension and vasodilatation, there is no in vitro evidence that CRF acts as a vasodilator...
  76. pmc Effects of pyrogenic immunomodulators on the release of corticotrophin-releasing factor-41 and prostaglandin E2 from the intact rat hypothalamus in vitro
    N G Milton
    Department of Clinical Biochemistry, University of Newcastle upon Tyne
    Br J Pharmacol 109:88-93. 1993
    ..interleukin (IL)-1 alpha and IL-1 beta, human IL-6 and rat interferon (INF) on corticotrophin-releasing factor-41 (CRF-41) and prostaglandin E2 (PGE2) release from the intact rat hypothalamus in vitro have been studied. 2...
  77. ncbi CRF and stress in fish
    Gert Flik
    Department of Animal Physiology, Institute for Neuroscience, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    Gen Comp Endocrinol 146:36-44. 2006
    ..Key players in the continuous adaptation process are corticotropin-releasing factor (CRF) from the hypothalamic nucleus preopticus (NPO), pituitary adrenocorticotropic hormone (ACTH) and cortisol produced ..
  78. pmc The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist
    T Z Baram
    Department of Pediatrics, University of California, Irvine 92697 4475, USA
    Brain Res 770:89-95. 1997
    b>Corticotropin releasing factor (CRF) is the key coordinator of the neuroendocrine and behavioral responses to stress...
  79. ncbi Some functional aspects of canine corticotrophs
    D J Middleton
    Faculty of Veterinary Medicine, Division of Comparative Endocrinology, State University, Utrecht, The Netherlands
    Horm Metab Res 19:632-5. 1987
    ..and functional significance of canine pituitary pars intermedia corticotrophs, ACTH and cortisol responses to CRF were studied in healthy dogs before and after treatment with dexamethasone...
  80. ncbi Autoregulation in the parathyroid glands by PTH/PTHrP receptor ligands in normal and uremic rats
    Ewa Lewin
    Nephrological Department B, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    Kidney Int 64:63-70. 2003
    ..Our aim was to search for the PTH/PTHrP receptor in rat parathyroid glands and to examine the effects of PTHrP 1-40 on PTH secretion in in vivo models of secondary hyperparathyroidism (HPT) in uremic rats...
  81. pmc Corticosterone differentially modulates expression of corticotropin releasing factor and arginine vasopressin mRNA in the hypothalamic paraventricular nucleus following either acute or repeated restraint stress
    S B Pinnock
    Department of Anatomy, University of Cambridge, Cambridge CB2 3DY UK
    Eur J Neurosci 13:576-84. 2001
    ..restraint stress induces well-characterized adaptations in the expression of either corticotropin-releasing factor (CRF) or arginine-vasopressin (AVP) mRNA in the parvocellular neurons of the hypothalamic paraventricular nucleus (PVN)...
  82. doi Stimulation of the inferior olivary complex alters the distribution of the type 1 corticotropin releasing factor receptor in the adult rat cerebellar cortex
    J B Tian
    Department of Neuroscience, The Ohio State University, 333 West 10th Avenue, Columbus, OH 43210, USA
    Neuroscience 153:308-17. 2008
    ..populations of climbing fibers, derived from the inferior olivary complex (IOC) contain the peptide corticotropin releasing factor (CRF) and that the expression of this peptide in climbing fibers could be modulated by the level of ..
  83. ncbi [Progressive cerebellar ataxia with diencephalic symptoms (Toyokura)--a case report]
    M Kitsu
    Department of Pediatrics, Neurological Institute, Tokyo Women's Medical College
    No To Hattatsu 24:273-7. 1992
    ..responded to the loading of hypothalamic hormones such as growth hormone releasing factor and corticotropin releasing factor, in spite of poor responses of GH under the insulin stimulation or sleep...
  84. ncbi Direct effects of stress on adrenocortical function
    D Pignatelli
    Institute of Histology and Embryology, Faculty of Medicine of Porto, Portugal
    Horm Metab Res 30:464-74. 1998
    ..as well as the existence of some local hormonal axis such as those resulting from the local production of renin or CRH in adrenal cells...
  85. ncbi Differential roles of corticotropin-releasing factor receptor subtypes 1 and 2 in opiate withdrawal and in relapse to opiate dependence
    L Lu
    National Laboratory of Medical Neurobiology, Shanghai Medical University, 138 Yi Xue Yuan Road, Shanghai 200032, P R China
    Eur J Neurosci 12:4398-404. 2000
    The possible effects on the morphine withdrawal signs of the nonspecific corticotropin-releasing factor (CRF) receptor antagonist alpha-helical CRF, the selective CRF receptor subtype 1 antagonist CP-154,526 and the selective CRF ..
  86. ncbi Signaling properties of mouse and human corticotropin-releasing factor (CRF) receptors: decreased coupling efficiency of human type II CRF receptor
    Y Xiong
    Endocrine Unit, Massachusetts General Hospital, Boston 02114, USA
    Endocrinology 136:1828-34. 1995
    b>CRF is the primary neuroregulator of the function of the hypothalamic-pituitary-adrenal axis. We have recently cloned a mouse CRF receptor (mCRF-R) complementary DNA (cDNA) from an AtT-20 cell cDNA library by polymerase chain reaction...
  87. ncbi Treatment of periorbital edema with human corticotropin-releasing factor after blepharoplasty
    S A Schendel
    Division of Plastic and Reconstructive Surgery, Stanford University Medical Center, Stanford, CA 94305 USA
    J Am Coll Surg 182:226-32. 1996
    ..Further research with a larger study population and other dosing regimens is indicated...
  88. ncbi [Seizures associated with fever in children of congenital adrenal hyperplasia]
    H Kawawaki
    Division of Pediatric Neurology, Osaka City General Hospital, Osaka
    No To Hattatsu 33:27-30. 2001
    ..hyponatremia), our findings implicate unknown factors in the pathogenesis such as excess secretion of corticotropin releasing factor (CRF) under stress, prolonged elevation of CRF during fetus life and linkage between CAH and febrile ..
  89. ncbi Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2beta by the CRF/urocortin family of peptides
    Bhawanjit K Brar
    The Clayton Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Endocrinology 145:1718-29. 2004
    Corticotropin-releasing factor (CRF) receptor (CRFR)-mediated activation of the ERKs 1/2-p42 and -44) has been reported for CRF, urocortin (Ucn)-I, and sauvagine...
  90. ncbi Evidence for an axonal localization of the type 2 corticotropin-releasing factor receptor during postnatal development of the mouse cerebellum
    K H Lee
    Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Exp Neurol 187:11-22. 2004
    Previous studies have described the embryonic and postnatal development of CRF, as well as the type 1 CRF receptor in the mouse cerebellum...
  91. pmc Central neuropeptide Y and the sigma ligand, JO 1784, reverse corticotropin-releasing factor-induced inhibition of gastric acid secretion in rats
    M Gue
    CURE VA Wadsworth Medical Center, Department of Medicine, Los Angeles, CA
    Br J Pharmacol 107:642-7. 1992
    ..en-1-ylamine hydrochloride], or neuropeptide Y (NPY) and corticotropin-releasing factor (CRF)-induced inhibition of gastric acid secretion were investigated in rats anaesthetized with urethane...
  92. ncbi Expression of genes encoding corticotropin-releasing factor (CRF), type 1 CRF receptor, and CRF-binding protein and localization of the gene products in the human ovary
    H Asakura
    Department of Reproductive Medicine, University of California San Diego School of Medicine, La Jolla 92093 0633, USA
    J Clin Endocrinol Metab 82:2720-5. 1997
    ..corticotropin-releasing factor (IrCRF) in the thecal-stromal cells of the human ovary and the ability of CRF to suppress estrogen production by human granulosa cells in vitro have been reported...
  93. ncbi Localization of the type 1 corticotropin releasing factor receptor (CRF-R1) in the embryonic mouse cerebellum
    James S King
    Department of Neuroscience, The Ohio State University, 333 W 10th Ave Columbus, Ohio 43210, USA
    J Neurocytol 32:305-16. 2003
    b>Corticotropin releasing factor (CRF) is present in the adult, as well as in the embryonic and postnatal rodent cerebellum. Further, the distribution of the type 1 CRF receptor has been described in adult and postnatal animals...
  94. ncbi Recent advances with the CRF1 receptor: design of small molecule inhibitors, receptor subtypes and clinical indications
    J R McCarthy
    Neurocrine Biosciences, Inc, San Diego, CA 92121, USA
    Curr Pharm Des 5:289-315. 1999
    Corticotropin-releasing factor (CRF) has been widely implicated as playing a major role in modulating the endocrine, autonomic, behavioral and immune responses to stress...
  95. ncbi Identification of two corticotropin-releasing factor receptors from Xenopus laevis with high ligand selectivity: unusual pharmacology of the type 1 receptor
    F M Dautzenberg
    Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Goettingen, Germany
    J Neurochem 69:1640-9. 1997
    Two cDNA clones encoding distinct members of the corticotropin-releasing factor (CRF) receptor family have been isolated from Xenopus laevis with PCR-based approaches...
  96. doi Corticotropin-releasing factor (CRF) is involved in the acute anorexic effect of alpha-melanocyte-stimulating hormone: a study using CRF-deficient mice
    Shoko Kawashima
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Peptides 29:2169-74. 2008
    ..Corticotropin-releasing factor (CRF) is a candidate for mediating the anorexic effect of alpha-MSH...
  97. ncbi Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists
    J Rivier
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 45:4737-47. 2002
    We present evidence that members of the corticotropin releasing factor (CRF) family assume distinct structures when interacting with the CRF(1) and CRF(2) receptors...
  98. pmc The effect of restraint stress on prepulse inhibition and on corticotropin-releasing factor (CRF) and CRF receptor gene expression in Wistar-Kyoto and Brown Norway rats
    Jane E Sutherland
    Department of Psychiatry, University of Connecticut Health Center, Farmington, CT 06030, USA
    Pharmacol Biochem Behav 97:227-38. 2010
    ..Corticotropin-releasing factor (CRF) is one of the most important neurotransmitters involved in behavioral components of the stress response, and ..
  99. pmc Reversal of CRF- and dopamine-induced stimulation of colonic motility by CCK and igmesine (JO 1784) in the rat
    M Gue
    Department of Pharmacology, INRA, Toulouse, France
    Br J Pharmacol 111:930-4. 1994
    1. The role of dopamine in the genesis of corticotropin releasing factor (CRF)- and emotional stress (ES)-induced stimulation of colonic motility, as well as the mechanism of antagonistic action of cholecystokinin octapeptide (CCK-8s) and ..
  100. pmc Subcellular plasticity of the corticotropin-releasing factor receptor in dendrites of the mouse bed nucleus of the stria terminalis following chronic opiate exposure
    A Jaferi
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 407 East 61st Street, New York, NY 10065, USA
    Neuroscience 163:143-54. 2009
    ..administration alters the expression levels of the stress-responsive peptide, corticotropin-releasing factor (CRF), in the bed nucleus of the stria terminalis (BNST)...
  101. ncbi Expression of corticotropin-releasing factor and CRF receptors in micturition pathways after cyclophosphamide-induced cystitis
    Jennifer LaBerge
    Dept of Anatomy, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Regul Integr Comp Physiol 291:R692-703. 2006
    Corticotropin-releasing factor (CRF) is a prominent neuropeptide involved in micturition reflexes, and different roles in these reflexes have been suggested...

Research Grants85

  1. Effects of early-life experience:role of CRH
    TALLIE Z Z BARAM; Fiscal Year: 2010
    ..persistent alterations of stress-related genes: reduced expression of hypothalamic corticotropin releasing hormone (CRH) was found by the applicant already by the end of the enriched-experience period on postnatal day 9, preceding ..
  2. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
    ..b) acute stress activates mast cells, an action blocked by pretreatment with corticotropin-releasing hormone (CRH) neutralizing antiserum, (c) stress increases blood-brain-barrier (BBB) permeability, which is inhibited by the CRH-..
  3. Neural Analysis of Maternal Aggression
    STEPHEN GAMMIE; Fiscal Year: 2006
    ..During lactation, decreases in corticotropin releasing hormone (CRH) neurotransmission have been linked to decreases in fear and anxiety...
  4. CRH-MRNA REGULATION-- ROLE IN NEONATAL SEIZURE POTENTIAL
    Tallie Z Baram; Fiscal Year: 2003
    ..The applicant has demonstrated that the stress-activated neuropeptide, corticotropin releasing hormone (CRH), a well established key mediator of the CNS stress-response, acts as a powerful, age-specific convulsant in the ..
  5. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..Corticotropin releasing hormone (CRH) is released from the hypothalamus under stress and activates the hypothalamic-pituitary-adrenal (HPA) axis...
  6. Stress Induces Skin Mast Cell Activation & Vasodilation
    Theoharis Theoharides; Fiscal Year: 2005
    ..by neuropeptides, and by acute immobilization stress through the local release of corticotropin releasing hormone (CRH) or urocortin (Ucn), which is more potent than CRH...
  7. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2004
    ..Corticotropin releasing hormone (CRH) and CRH receptors (CRH-R) are also expressed and fully functional in rodent and human skin, but its significance ..
  8. CRH Receptors and Stress Response Pathways
    Mary Stenzel Poore; Fiscal Year: 2007
    ..We propose that corticotropin-releasing hormone (CRH) and its receptors are critical in achieving proper initiation and termination responses to stress...
  9. GR-Mediated Epigenetic Regulation of the CRH Gene
    ROSALIE MARIE UHT; Fiscal Year: 2010
    ..that synthesize and secrete the peptide that triggers the stress response, corticotropin-releasing hormone (CRH), are insensitive to glucocorticoid down-regulation...
  10. GR-Mediated Epigenetic Regulation of the CRH Gene
    ROSALIE UHT; Fiscal Year: 2009
    ..that synthesize and secrete the peptide that triggers the stress response, corticotropin-releasing hormone (CRH), are insensitive to glucocorticoid down-regulation...
  11. CRH-mRNA Regulation: Role in Neonatal Seizure Potential
    Tallie Z Baram; Fiscal Year: 2007
    ..goal of this proposal is to determine the role of the stress-neuromodulator corticotropin releasing hormone (CRH) in early-life neuroplasticity that contributes to neurological disease...
  12. Corticotropin-Releasing Hormone-Binding Protein
    AUDREY SEASHOLTZ; Fiscal Year: 2004
    DESCRIPTION: (Scanned from the applicant's abstract) Corticotropin-releasing hormone (CRH) is widely recognized as the key physiological regulator of the mammalian stress response...
  13. STRESS INDUCED SKIN MAST CELL ACTIVATION & VASODILATION
    Theoharis C Theoharides; Fiscal Year: 2010
    ..The objective of this application is to identify the contribution of the corticotropin-releasing hormone (CRH) receptors and neurotensin (NT) receptor-1 in stress-induced skin mast cell activation and increased vascular ..
  14. STRESS INDUCED SKIN MAST CELL ACTIVATION & VASODILATION
    Theoharis Theoharides; Fiscal Year: 2009
    ..The objective of this application is to identify the contribution of the corticotropin-releasing hormone (CRH) receptors and neurotensin (NT) receptor-1 in stress-induced skin mast cell activation and increased vascular ..
  15. STRESS INDUCED SKIN MAST CELL ACTIVATION & VASODILATION
    Theoharis Theoharides; Fiscal Year: 2007
    ..The objective of this application is to identify the contribution of the corticotropin-releasing hormone (CRH) receptors and neurotensin (NT) receptor-1 in stress-induced skin mast cell activation and increased vascular ..
  16. MODEL OF HYPERCORTISOLISM FOR MAJOR DEPRESSIONS
    Alan Schatzberg; Fiscal Year: 1999
    ..To determine whether hyper-responsiveness is due to corticotropin releasing hormone (CRH) and/or ACTH potentiation effects on the adrenal cortex, ACTH stimulation tests will also be administered after ..
  17. Investigations into the mouse olivocochlear system
    Douglas Vetter; Fiscal Year: 2007
    Corticotropin releasing hormone (CRH) receptors, and urocortin, a member of the CRH family of peptides, has recently been discovered expressed in outer hair cells and olivocochlear terminals, respectively...
  18. Cytokine-CRH Interactions in IFN-alfa-Induced Depression
    Charles Raison; Fiscal Year: 2009
    ..depression and induce the production and release of central nervous system (CNS) corticotropin-releasing hormone (CRH), which is believed to be a key mediator of depression...
  19. Cytokine-CRH Interactions in IFN-alfa-Induced Depression
    Charles Raison; Fiscal Year: 2007
    ..depression and induce the production and release of central nervous system (CNS) corticotropin-releasing hormone (CRH), which is believed to be a key mediator of depression...
  20. CRH AND INFLAMMATION IN CEREBRAL ISCHEMIC INJURY
    Mary Stenzel Poore; Fiscal Year: 2002
    ..Corticotropin-releasing hormone (CRH), a neuropeptide first identified as a hypothalamic releasing hormone that mediates the stress response, is also ..
  21. Studies of CRH and Alcohol Effects
    Tamara Phillips; Fiscal Year: 2005
    ..We shall focus on the role of corticotropin-releasing hormone (CRH), the critical mediator of the stress response, in determining these alcohol effects...
  22. Form/function of Extended Amygdala/Accumbens Shell:CRF
    DANIEL ZAHM; Fiscal Year: 2005
    Corticotropin-releasing factor (CRF) is the major mediator of stress responses in the brain and has been implicated in both normal fear and pathological anxiety...
  23. Stress and CRF System Effects on Information Processing
    Victoria B Risbrough; Fiscal Year: 2010
    ..use murine models to elucidate the mechanisms underlying the effects of stress and the neuropeptide corticotropin releasing factor (CRF) on anxiety-like behavior related to post-traumatic stress disorder (PTSD)...