Gene Symbol: CRH
Description: corticotropin releasing hormone
Alias: CRF, CRH1, corticoliberin, corticotropin-releasing factor
Species: human
Products:     CRH

Top Publications

  1. Sato H, Nagashima Y, Chrousos G, Ichihashi M, Funasak Y. The expression of corticotropin-releasing hormone in melanoma. Pigment Cell Res. 2002;15:98-103 pubmed
    ..whether the high expression of POMC derives from increased expression of corticotropin-releasing hormone (CRH) and the possible role of CRH as a melanoma growth factor...
  2. Zbytek B, Slominski A. Corticotropin-releasing hormone induces keratinocyte differentiation in the adult human epidermis. J Cell Physiol. 2005;203:118-26 pubmed
    Previously we documented that human epidermis exclusively expresses corticotropin releasing hormone receptor 1 (CRH-R1)...
  3. Combi R, Dalprà L, Ferini Strambi L, Tenchini M. Frontal lobe epilepsy and mutations of the corticotropin-releasing hormone gene. Ann Neurol. 2005;58:899-904 pubmed
    ..In particular, on chromosome 8, corticotropin-releasing hormone gene (CRH) appears to be a good candidate. We therefore searched for CRH mutations in the proband...
  4. Chen X, Zhu H, Meng Q, Zhou J. Estrogen receptor-alpha and -beta regulate the human corticotropin-releasing hormone gene through similar pathways. Brain Res. 2008;1223:1-10 pubmed publisher
    Corticotropin-releasing hormone (CRH) plays a central role in controlling stress response. In this study, we aimed to identify the regulatory effect of estrogen receptor (ER) on CRH and the underlying mechanism...
  5. Torricelli M, Novembri R, Bloise E, De Bonis M, Challis J, Petraglia F. Changes in placental CRH, urocortins, and CRH-receptor mRNA expression associated with preterm delivery and chorioamnionitis. J Clin Endocrinol Metab. 2011;96:534-40 pubmed publisher
    ..Corticotropin releasing-hormone (CRH) and Urocortins (Ucns) are involved in the pathophysiology of PTD...
  6. McLean M, Bisits A, Davies J, Woods R, Lowry P, Smith R. A placental clock controlling the length of human pregnancy. Nat Med. 1995;1:460-3 pubmed of 485 pregnant women we have demonstrated that placental secretion of corticotropin-releasing hormone (CRH) is a marker of this process and that measurement of the maternal plasma CRH concentration as early as 16-20 weeks ..
  7. Florio P, Severi F, Ciarmela P, Fiore G, Calonaci G, Merola A, et al. Placental stress factors and maternal-fetal adaptive response: the corticotropin-releasing factor family. Endocrine. 2002;19:91-102 pubmed
    ..Among these factors, corticotropin-releasing factor (CRF) has been one of the more investigated in the last decade...
  8. Sehringer B, Zahradnik H, Simon M, Ziegler R, Noethling C, Schaefer W. mRNA expression profiles for corticotrophin-releasing hormone, urocortin, CRH-binding protein and CRH receptors in human term gestational tissues determined by real-time quantitative RT-PCR. J Mol Endocrinol. 2004;32:339-48 pubmed
    Increasing maternal plasma levels of corticotrophin-releasing hormone (CRH) during the last weeks of pregnancy suggest that this stress hormone plays an important role in the control of human parturition...
  9. Timpl P, Spanagel R, Sillaber I, Kresse A, Reul J, Stalla G, et al. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nat Genet. 1998;19:162-6 pubmed
    Corticotropin-releasing hormone (CRH) is a potent mediator of endocrine, autonomic, behavioural and immune responses to stress, and has been implicated in the stress-like and other aversive consequences of drug abuse, such as withdrawal ..

More Information

Publications129 found, 100 shown here

  1. Aggelidou E, Hillhouse E, Grammatopoulos D. Up-regulation of nitric oxide synthase and modulation of the guanylate cyclase activity by corticotropin-releasing hormone but not urocortin II or urocortin III in cultured human pregnant myometrial cells. Proc Natl Acad Sci U S A. 2002;99:3300-5 pubmed
    The biological actions of corticotropin-releasing hormone (CRH) in the human myometrium during pregnancy and labor are unknown...
  2. Wetzka B, Sehringer B, Schafer W, Biller S, Hor C, Benedek E, et al. Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term. Exp Clin Endocrinol Diabetes. 2003;111:154-61 pubmed
    Recent research suggests a significant role for placental corticotropin-releasing hormone (CRH) in controlling human parturition...
  3. Claes S, Villafuerte S, Forsgren T, Sluijs S, Del Favero J, Adolfsson R, et al. The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. Biol Psychiatry. 2003;54:867-72 pubmed
    ..001). The corticotropin releasing hormone binding protein gene is likely to be involved in the genetic vulnerability for major depression. ..
  4. Slominski A, Zbytek B, Pisarchik A, Slominski R, Zmijewski M, Wortsman J. CRH functions as a growth factor/cytokine in the skin. J Cell Physiol. 2006;206:780-91 pubmed
    We tested the effect of CRH and related peptides in a large panel of human skin cells for growth factor/cytokine activities...
  5. Gkountelias K, Tselios T, Venihaki M, Deraos G, Lazaridis I, Rassouli O, et al. Alanine scanning mutagenesis of the second extracellular loop of type 1 corticotropin-releasing factor receptor revealed residues critical for peptide binding. Mol Pharmacol. 2009;75:793-800 pubmed publisher
    Upon binding of the corticotropin-releasing factor (CRF) analog sauvagine to the type 1 CRF receptor (CRF(1)), the amino-terminal portion of the peptide has been shown to lie near Lys257 in the receptor's second extracellular loop (EL2)...
  6. Hanstein R, Trotter J, Behl C, Clement A. Increased connexin 43 expression as a potential mediator of the neuroprotective activity of the corticotropin-releasing hormone. Mol Endocrinol. 2009;23:1479-93 pubmed publisher
    b>CRH is a major central stress mediator, but also a potent neuroprotective effector. The mechanisms by which CRH mediates its neuroprotective actions are largely unknown...
  7. Lang U, Borgwardt S. Molecular mechanisms of depression: perspectives on new treatment strategies. Cell Physiol Biochem. 2013;31:761-77 pubmed publisher
    ..As an endocrinological and stress disorder depression has been connected with the concentration of free T4, TSH, CRH, arginine vasopressin, corticotrophin, corticosteroid release and ACTH...
  8. Ludwig B, Roy B, Dwivedi Y. Role of HPA and the HPG Axis Interaction in Testosterone-Mediated Learned Helpless Behavior. Mol Neurobiol. 2019;56:394-405 pubmed publisher
    ..receptor, (Ar); estrogen receptor-β (Er-β)) and HPA axis-related genes (corticotropin-releasing hormone, (Crh); glucocorticoid receptor, (Nr3c1); corticotropin-releasing hormone receptor 1, (Crhr1); corticotropin-releasing ..
  9. Couvineau A, Laburthe M. The family B1 GPCR: structural aspects and interaction with accessory proteins. Curr Drug Targets. 2012;13:103-15 pubmed
    ..Here, we review the current knowledge regarding: i) the structure of family B1 GPCR binding domain for natural ligands and ii) the interaction of family B1 GPCRs with accessory proteins. ..
  10. Vodicka M, Ergang P, Hrncir T, Mikulecká A, Kvapilová P, Vagnerova K, et al. Microbiota affects the expression of genes involved in HPA axis regulation and local metabolism of glucocorticoids in chronic psychosocial stress. Brain Behav Immun. 2018;73:615-624 pubmed publisher
    ..interaction on HPA axis activity and on the expression of colonic corticotropin-releasing hormone (CRH) system, cytokines and 11β-hydroxysteroid dehydrogenase type 1 (11HSD1), an enzyme that determines locally ..
  11. Panossian A, Seo E, Efferth T. Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. Phytomedicine. 2018;50:257-284 pubmed publisher
    ..All samples tested showed significant effects on the expression of genes encoding neurohormones CRH, GNRH, UCN, G-protein-coupled and other transmembrane receptors TLR9, PRLR, CHRNE, GP1BA, PLXNA4, a ligand-..
  12. Nowacka Chmielewska M, Kasprowska Liśkiewicz D, Barski J, Obuchowicz E, Małecki A. The behavioral and molecular evaluation of effects of social instability stress as a model of stress-related disorders in adult female rats. Stress. 2017;20:549-561 pubmed publisher
    ..CSIS significantly reduced expression of CRH-R1 (corticotropin-releasing hormone receptor type 1) in the hippocampus...
  13. Zheng L, Tan X, Cui X, Yuan H, Li H, Jiao G, et al. Preimplantation maternal stress impairs embryo development by inducing oviductal apoptosis with activation of the Fas system. Mol Hum Reprod. 2016;22:778-790 pubmed
    ..At the end of PIRS, levels of glucorticoids (GC), corticotropin-releasing hormone (CRH)and redox potential were measured in serum, while levels of GC, GC receptor (GR), CRH, CRH receptor (CRHR), Fas and ..
  14. Sanna F, Bratzu J, Argiolas A, Melis M. Oxytocin induces penile erection and yawning when injected into the bed nucleus of the stria terminalis: Involvement of glutamic acid, dopamine, and nitric oxide. Horm Behav. 2017;96:52-61 pubmed publisher
    ..a GABAA receptor antagonist, phaclofen (5?g), a GABAB receptor antagonist, CP 376395, a CRF receptor-1 antagonist (5?g), or astressin 2B, a CRF receptor-2 antagonist (150ng)...
  15. Ergang P, Vodička M, Soták M, Klusoňová P, Behuliak M, Řeháková L, et al. Differential impact of stress on hypothalamic-pituitary-adrenal axis: gene expression changes in Lewis and Fisher rats. Psychoneuroendocrinology. 2015;53:49-59 pubmed publisher
    ..of 11β-hydroxysteroid dehydrogenase type 1 (11HSD1) and the neuropeptides corticotropin-releasing hormone (CRH), urocortins 2 and 3(UCN2, UCN3), arginine vasopressin (AVP), oxytocin (OXT) and adenylate cyclase-activating ..
  16. Shahin S, Banerjee S, Swarup V, Singh S, Chaturvedi C. From the Cover: 2.45-GHz Microwave Radiation Impairs Hippocampal Learning and Spatial Memory: Involvement of Local Stress Mechanism-Induced Suppression of iGluR/ERK/CREB Signaling. Toxicol Sci. 2018;161:349-374 pubmed publisher serum corticosterone level and the expression of glucocorticoid receptor, corticotropin-releasing hormone (CRH), inducible nitric oxide synthase (i-NOS), iGluRs, PSD-95-neuronal NOS (n-NOS) system, protein kinase A, protein ..
  17. Paruthiyil S, Hagiwara S, Kundassery K, Bhargava A. Sexually dimorphic metabolic responses mediated by CRF2 receptor during nutritional stress in mice. Biol Sex Differ. 2018;9:49 pubmed publisher
    ..Peptide hormones corticotropin-releasing factor (CRF) and urocortins (UCN) mediate stress responses via activation and feedback to the hypothalamic-pituitary-adrenal (..
  18. Grundwald N, Brunton P. Prenatal stress programs neuroendocrine stress responses and affective behaviors in second generation rats in a sex-dependent manner. Psychoneuroendocrinology. 2015;62:204-16 pubmed publisher
    ..This was associated with greater corticotropin releasing hormone (Crh) mRNA expression in the paraventricular nucleus and reduced hippocampal glucocorticoid (Gr) and mineralocorticoid ..
  19. Jokinen J, Boström A, Chatzittofis A, Ciuculete D, Öberg K, Flanagan J, et al. Methylation of HPA axis related genes in men with hypersexual disorder. Psychoneuroendocrinology. 2017;80:67-73 pubmed publisher
    ..2000bp of the transcriptional start site of the following HPA-axis coupled genes: Corticotropin releasing hormone (CRH), corticotropin releasing hormone binding protein (CRHBP), corticotropin releasing hormone receptor 1 (CRHR1), ..
  20. Vranjkovic O, Van Newenhizen E, Nordness M, Blacktop J, Urbanik L, Mathy J, et al. Enhanced CRFR1-Dependent Regulation of a Ventral Tegmental Area to Prelimbic Cortex Projection Establishes Susceptibility to Stress-Induced Cocaine Seeking. J Neurosci. 2018;38:10657-10671 pubmed publisher
    ..This study examined the role of a corticotropin releasing factor (CRF)-regulated dopaminergic projection from the ventral tegmental area (VTA) to the prelimbic cortex ..
  21. Cho W, Kang J, Park Y. Corticotropin-Releasing Hormone (CRH) Promotes Macrophage Foam Cell Formation via Reduced Expression of ATP Binding Cassette Transporter-1 (ABCA1). PLoS ONE. 2015;10:e0130587 pubmed publisher
    ..Corticotropin-releasing hormone (CRH), which is released by neurosecretory cells in the hypothalamus, peripheral nerve terminals and epithelial cells, ..
  22. Bohacek J, Manuella F, Roszkowski M, Mansuy I. Hippocampal gene expression induced by cold swim stress depends on sex and handling. Psychoneuroendocrinology. 2015;52:1-12 pubmed publisher
    ..examined the involvement of two key stress-related hormones, corticosterone and corticotropin releasing hormone (Crh)...
  23. Lu B, Diz Chaves Y, Markovic D, Contarino A, Penicaud L, Fanelli F, et al. The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms. Int J Obes (Lond). 2015;39:408-17 pubmed publisher
    The corticotrophin-releasing factor (CRF)/urocortin system is expressed in the adipose tissue of mammals, but its functional role in this tissue remains unknown...
  24. Liu X, Liu C, Li J, Zhang X, Song F, Xu J. Urocortin attenuates myocardial fibrosis in diabetic rats via the Akt/GSK-3β signaling pathway. Endocr Res. 2016;41:148-57 pubmed publisher
    ..rats were randomly divided into 4 groups: diabetic control group, urocortin, urocortin + astressin (a selective CRF receptor 2 antagonist) and urocortin + triciribine (an Akt pathway blocker)...
  25. Bethea C, Reddy A, Flowers M, Shapiro R, Colman R, Abbott D, et al. High fat diet decreases beneficial effects of estrogen on serotonin-related gene expression in marmosets. Prog Neuropsychopharmacol Biol Psychiatry. 2015;58:71-80 pubmed publisher
    ..05). There was a significant difference between treatments in corticotrophin releasing factor-receptor 2 (CRF-R2) expression (p=0.012). E increased CRF-R2 and this stimulatory effect was blocked by HFD (p<0.01)...
  26. Uribe Mariño A, Gassen N, Wiesbeck M, Balsevich G, Santarelli S, Solfrank B, et al. Prefrontal Cortex Corticotropin-Releasing Factor Receptor 1 Conveys Acute Stress-Induced Executive Dysfunction. Biol Psychiatry. 2016;80:743-753 pubmed publisher
    ..Corticotropin-releasing factor (CRF), through CRF receptor 1 (CRFR1), constitutes a key element of the stress response...
  27. GÄ…dek Michalska A, Tadeusz J, Rachwalska P, Bugajski J. Cytokines, prostaglandins and nitric oxide in the regulation of stress-response systems. Pharmacol Rep. 2013;65:1655-62 pubmed
    ..of glucocorticoid (GC)-induced reduction of HPA axis signaling and increased corticotrophin-releasing hormone (CRH) secretion from the hypothalamic paraventricular nucleus (PVN) and extra-hypothalamic neurons...
  28. Walczewska J, Dzieża Grudnik A, Siga O, Grodzicki T. The role of urocortins in the cardiovascular system. J Physiol Pharmacol. 2014;65:753-66 pubmed
    ..Ucn) 1, 2 and 3 are a group of endogenous peptide hormones belonging to the corticotropin-releasing hormone (CRH) family of peptides...
  29. Wang W, Zhang X, Liu D, Qiu J, Wang X, Zhou J. Corticotropin-releasing hormone and urocortin promote phagocytosis of rat macrophages through convergent but distinct pathways. Life Sci. 2015;122:100-7 pubmed publisher
    ..This study aims to explore the underlying mechanism of corticotropin-releasing hormone (CRH) and urocortin (UCN)-promoted phagocytosis of rat macrophages...
  30. Florio P, Rossi M, Sigurdardottir M, Ciarmela P, Luisi S, Vigano P, et al. Paracrine regulation of endometrial function: interaction between progesterone and corticotropin-releasing factor (CRF) and activin A. Steroids. 2003;68:801-7 pubmed
    ..Among the local factors produced by the human endometrium, corticotropin-releasing factor (CRF) and activin A have been evaluated in terms of localization and effects...
  31. Minatto G, Barbosa Filho V, Berria J, Petroski E. School-Based Interventions to Improve Cardiorespiratory Fitness in Adolescents: Systematic Review with Meta-analysis. Sports Med. 2016;46:1273-92 pubmed publisher
    School-based intervention can contribute to the promotion of cardiorespiratory fitness (CRF) in adolescents...
  32. Vom Berg Maurer C, Trivedi C, Bollmann J, De Marco R, Ryu S. The Severity of Acute Stress Is Represented by Increased Synchronous Activity and Recruitment of Hypothalamic CRH Neurons. J Neurosci. 2016;36:3350-62 pubmed publisher
    ..Corticotropin-releasing hormone (CRH) released from the paraventricular nucleus of the hypothalamus is a major regulator of the HPA axis...
  33. Fletcher P, Zemkova H, Stojilkovic S, Sherman A. Modeling the diversity of spontaneous and agonist-induced electrical activity in anterior pituitary corticotrophs. J Neurophysiol. 2017;117:2298-2311 pubmed publisher action potentials spontaneously and in response to stimulation with corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP), and such electrical activity is critical for calcium signaling and calcium-..
  34. Idriss A, Hu Y, Hou Z, Hu Y, Sun Q, Omer N, et al. Dietary betaine supplementation in hens modulates hypothalamic expression of cholesterol metabolic genes in F1 cockerels through modification of DNA methylation. Comp Biochem Physiol B Biochem Mol Biol. 2018;217:14-20 pubmed publisher
    ..05). These changes coincided with a significant down-regulation of BDNF and CRH, and a significant up-regulation of NPY mRNA expression...
  35. Vamvakopoulos N, Chrousos G. Structural organization of the 5' flanking region of the human corticotropin releasing hormone gene. DNA Seq. 1993;4:197-206 pubmed
    ..The structural information reported represents a first step in the study of regulation of the hCRH gene at the molecular level. ..
  36. Florio P, Romero R, Chaiworapongsa T, Kusanovic J, Torricelli M, Lowry P, et al. Amniotic fluid and umbilical cord plasma corticotropin-releasing factor (CRF), CRF-binding protein, adrenocorticotropin, and cortisol concentrations in intraamniotic infection and inflammation at term. J Clin Endocrinol Metab. 2008;93:3604-9 pubmed publisher
    Pregnant tissues express corticotropin-releasing factor (CRF), a peptide modulating fetal and placental ACTH and cortisol secretion. These actions are modulated by the locally expressed CRF-binding protein (CRF-BP)...
  37. Li X, Shao B, Lin C, O Byrne K, Lin Y. Stress-induced inhibition of LH pulses in female rats: role of GABA in arcuate nucleus. J Mol Endocrinol. 2015;55:9-19 pubmed publisher
    ..Besides the corticotrophin-releasing factor (CRF), this effect also might be mediated via GABAergic signaling within the arcuate nucleus (ARC) since its inhibitory ..
  38. Kim D, Han S, Choi C, Sohn M, Lee C. Efficacy of pulsed radiofrequency medial branch treatment in low back pain patients. J Back Musculoskelet Rehabil. 2016;29:361-366 pubmed
    ..of the medial branch in patients with lower back pain was not as long lasting as that of continuous radiofrequency (CRF) thermo-coagulation techniques...
  39. Bagosi Z, Palotai M, Simon B, Bokor P, Buzás A, Balangó B, et al. Selective CRF2 receptor agonists ameliorate the anxiety- and depression-like state developed during chronic nicotine treatment and consequent acute withdrawal in mice. Brain Res. 2016;1652:21-29 pubmed publisher
    ..the present study was to investigate the effects of the selective agonists of the corticotropin-releasing factor (CRF) 2 receptor, urocortin 2 (UCN 2) and urocortin 3 (UCN 3), on the anxiety- and depression-like signs induced by ..
  40. Chen S. Network analysis of Urocortins. Neuro Endocrinol Lett. 2016;37:461-466 pubmed
    Urocortins (Ucns), members of corticotropin releasing factor family, play critical roles in a number of pathological and physiological conditions...
  41. Dunlop B, Binder E, Iosifescu D, Mathew S, Neylan T, Pape J, et al. Corticotropin-Releasing Factor Receptor 1 Antagonism Is Ineffective for Women With Posttraumatic Stress Disorder. Biol Psychiatry. 2017;82:866-874 pubmed publisher
    ..fixed-dose clinical trial evaluating the efficacy of GSK561679, a corticotropin-releasing factor receptor 1 (CRF1 receptor) antagonist in adult women with PTSD...
  42. Rademaker M, Richards A. Urocortins: Actions in health and heart failure. Clin Chim Acta. 2017;474:76-87 pubmed publisher
    The urocortins (Ucns), endogenous peptides belonging to the corticotropin-releasing factor (CRF) family, are increasingly recognized as having diverse and important multi-system functions, especially within the cardiovascular system...
  43. Zafrir B, Azaiza M, Gaspar T, Dobrecky Mery I, Azencot M, Lewis B, et al. Low cardiorespiratory fitness and coronary artery calcification: Complementary cardiovascular risk predictors in asymptomatic type 2 diabetics. Atherosclerosis. 2015;241:634-40 pubmed publisher
    Despite its well-established prognostic value, cardiorespiratory fitness (CRF) is not incorporated routinely in risk assessment tools...
  44. Szakács J, Csabafi K, Lipták N, Szabó G. The effect of obestatin on anxiety-like behaviour in mice. Behav Brain Res. 2015;293:41-5 pubmed publisher
    ..blockage with [d-Lys3]-Growth Hormone Releasing Peptide-6 ([d-Lys3]- GHRP6) or corticotropin-releasing hormone (CRH) receptor 1 antagonism with antalarmin...
  45. Camille Melón L, Maguire J. GABAergic regulation of the HPA and HPG axes and the impact of stress on reproductive function. J Steroid Biochem Mol Biol. 2016;160:196-203 pubmed publisher
    ..HPG) axes are regulated by GABAergic signaling at the level of corticotropin-releasing hormone (CRH) and gonadotropin-releasing hormone (GnRH) neurons, respectively...
  46. Harber M, Kaminsky L, Arena R, Blair S, Franklin B, Myers J, et al. Impact of Cardiorespiratory Fitness on All-Cause and Disease-Specific Mortality: Advances Since 2009. Prog Cardiovasc Dis. 2017;60:11-20 pubmed publisher
    Cardiorespiratory fitness (CRF) has been one of the most widely examined physiological variables, particularly as it relates to functional capacity and human performance...
  47. Krause E, Pati D, Frazier C. Chronic salt-loading reduces basal excitatory input to CRH neurons in the paraventricular nucleus and accelerates recovery from restraint stress in male mice. Physiol Behav. 2017;176:189-194 pubmed publisher
    Neurons synthesizing corticotrophin-releasing hormone (CRH) in the paraventricular nucleus of the hypothalamus (PVN) are activated during acute stress and act via the hypothalamic-pituitary-adrenal (HPA) axis to increase systemic levels ..
  48. Georgiou P, Zanos P, Bhat S, Tracy J, Merchenthaler I, McCarthy M, et al. Dopamine and Stress System Modulation of Sex Differences in Decision Making. Neuropsychopharmacology. 2018;43:313-324 pubmed publisher
    ..D2R) antagonist (eticlopride), D2R agonist (quinpirole), corticotropin-releasing factor 1 (CRF1) antagonist (antalarmin), and α2-adrenergic receptor antagonist (yohimbine; used as a ..
  49. Machado Vieira R, Henter I, Zarate C. New targets for rapid antidepressant action. Prog Neurobiol. 2017;152:21-37 pubmed publisher
    ..non-glutamatergic targets for potential rapid antidepressant effects, including the cholinergic system (scopolamine), the opioid system (ALKS-5461), corticotropin releasing factor (CRF) receptor antagonists (CP-316,311), and others.
  50. Zalachoras I, Verhoeve S, Toonen L, van Weert L, van Vlodrop A, Mol I, et al. Isoform switching of steroid receptor co-activator-1 attenuates glucocorticoid-induced anxiogenic amygdala CRH expression. Mol Psychiatry. 2016;21:1733-1739 pubmed publisher
    ..maladaptive GR-mediated effects on fear-motivated behavior that are linked to corticotropin releasing hormone (CRH)...
  51. Diz Chaves Y, Gil Lozano M, Toba L, Fandiño J, Ogando H, Gonzalez Matias L, et al. Stressing diabetes? The hidden links between insulinotropic peptides and the HPA axis. J Endocrinol. 2016;230:R77-94 pubmed publisher
    ..Thus, the anorectic activity of GLP-1 could be mediated by increasing CRF at the hypothalamic level, while its lipolytic effects could imply a local increase in glucocorticoids and ..
  52. Serefoglu Cabuk K, Esen B, Atalay K, Kirgiz A, Aydin R. Alterations in biomechanical properties of the cornea among patients with polycystic kidney disease. Int Ophthalmol. 2018;38:1559-1564 pubmed publisher
    ..Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg) and corneal-compensated intraocular pressure (IOPcc) were ..
  53. Jia K, Zheng Y, Zhang Y, Liu J, Jiao R, Pan Y, et al. Banxia-houpu decoction restores glucose intolerance in CUMS rats through improvement of insulin signaling and suppression of NLRP3 inflammasome activation in liver and brain. J Ethnopharmacol. 2017;209:219-229 pubmed publisher
    ..Serum levels of corticosterone, corticotropin-releasing factor (CRF), insulin and interleukin-1 beta (IL-1β) were measured by commercial enzyme-linked immunosorbent assay kits, ..
  54. Bueno Antequera J, Oviedo Caro M, Munguía Izquierdo D. Sedentary behaviour, physical activity, cardiorespiratory fitness and cardiometabolic risk in psychosis: The PsychiActive project. Schizophr Res. 2018;195:142-148 pubmed publisher
    ..independent associations of sedentary behaviour (SB), physical activity (PA), and cardiorespiratory fitness (CRF) with clustered (CCRS) and individual cardiometabolic risk (waist circumference [waist], systolic/diastolic blood ..
  55. Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, et al. Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat. Cell Rep. 2018;22:706-721 pubmed publisher
    ..Here, we show that activation of a subset of corticotropin-releasing hormone (CRH)-positive neurons in the rostral region of the paraventricular hypothalamus (PVH) induces selection of an HCD over ..
  56. Gottowik J, Goetschy V, Henriot S, Kitas E, Fluhman B, Clerc R, et al. Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin. Neuropharmacology. 1997;36:1439-46 pubmed
    ..4 and 6.3 pmol/mg protein. Agents known to interact with CRF receptors potently competed for binding in each case...
  57. Fontes B, Ambrósio R, Velarde G, Nosé W. Corneal biomechanical evaluation in healthy thin corneas compared with matched keratoconus cases. Arq Bras Oftalmol. 2011;74:13-6 pubmed
    To evaluate and compare corneal hysteresis (CH) and corneal resistance factor (CRF) in healthy eyes with a central corneal thickness (CCT) < 505 µm with CH and CRF in gender-, age-, and CCT-matched keratoconus cases, and to ..
  58. Teto G, Kanmogne G, Torimiro J, Alemnji G, Nguemaim F, Takou D, et al. Lipid peroxidation and total cholesterol in HAART-naïve patients infected with circulating recombinant forms of human immunodeficiency virus type-1 in Cameroon. PLoS ONE. 2013;8:e65126 pubmed publisher
    ..of the biochemical parameters, but by grouping them as pure subtypes and circulating recombinant forms (CRFs), the CRF significantly influenced TC levels. TC was significantly lower in patients infected with CRF (0.87±0...
  59. Bang H, Yeun E, Ham E, Jeon M, An J. Perceptions about cancer-related fatigue among cancer patients using Q methodology. Eur J Oncol Nurs. 2016;20:64-70 pubmed publisher
    Cancer-related fatigue (CRF) is a common subjective feeling and disabling symptom complex experienced by patients with cancer...
  60. Negrete R, García Gutiérrez M, Manzanares J, Maldonado R. Involvement of the dynorphin/KOR system on the nociceptive, emotional and cognitive manifestations of joint pain in mice. Neuropharmacology. 2017;116:315-327 pubmed publisher
    ..Alterations of corticotropin-releasing factor (CRF) on the amygdala and hippocampus and down regulation of histone 3 acetylation on the amygdala suggest a possible ..
  61. Rodriguez F, Coveñas R. Targeting NPY, CRF/UCNs and NPS Neuropeptide Systems to Treat Alcohol Use Disorder (AUD). Curr Med Chem. 2017;24:2528-2558 pubmed publisher
    ..Among them, Neuropeptide Y (NPY), Corticotropin-releasing factor (CRF)/Urocortins and Neuropeptide S (NPS) cross-talk, and are responsible for some of the maladaptation processes that ..
  62. Koprdova R, Osacka J, Mach M, Kiss A. Acute Impact of Selected Pyridoindole Derivatives on Fos Expression in Different Structures of the Rat Brain. Cell Mol Neurobiol. 2018;38:171-180 pubmed publisher
    ..Fos-labeled sections were counterstained with neuropeptides including corticoliberine (CRH), oxytocin (OXY), vasopressin (AVP), and vasoactive intestinal polypeptide (VIP) and processed for ..
  63. Seidel L, Zarzycka B, Zaidi S, KATRITCH V, Coin I. Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells. elife. 2017;6: pubmed publisher
    ..The data enabled generating atomistic models of CRF- and CRF(12-41)-bound CRF1R, further explored by molecular dynamics simulations...
  64. Chan A, Yo T, Wang X, Ng T, Chae J, Yeo H, et al. Minimal Clinically Important Difference of the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF) for Fatigue Worsening in Asian Breast Cancer Patients. J Pain Symptom Manage. 2018;55:992-997.e2 pubmed publisher
    ..50 to 10.79 points. The MCID can be used to interpret the clinical significance of fatigue deterioration in patients with breast cancer and to determine sample sizes for future clinical trials. ..
  65. Klampfl S, Brunton P, Bayerl D, Bosch O. CRF-R1 activation in the anterior-dorsal BNST induces maternal neglect in lactating rats via an HPA axis-independent central mechanism. Psychoneuroendocrinology. 2016;64:89-98 pubmed publisher
    Adequate maternal behavior in rats requires minimal corticotropin-releasing factor receptor (CRF-R) activation in the medial-posterior bed nucleus of the stria terminalis (mpBNST)...
  66. Zemkova H, Tomić M, Kucka M, Aguilera G, Stojilkovic S. Spontaneous and CRH-Induced Excitability and Calcium Signaling in Mice Corticotrophs Involves Sodium, Calcium, and Cation-Conducting Channels. Endocrinology. 2016;157:1576-89 pubmed publisher
    ..In quiescent cells, CRH depolarized the membrane, leading to initial single spiking and sustained bursting; in active cells, CRH further ..
  67. Cardoso J, Bergqvist C, Félix R, Larhammar D. Corticotropin-releasing hormone family evolution: five ancestral genes remain in some lineages. J Mol Endocrinol. 2016;57:73-86 pubmed publisher
    ..Then, 2R resulted in a total of five members: one subfamily consists of CRH1, CRH2, and UCN1. The other subfamily contains UCN2 and UCN3...
  68. Yu C, Li M, Wang Y, Liu Y, Yan C, Pan J, et al. MiR-375 Mediates CRH Signaling Pathway in Inhibiting E2 Synthesis in Porcine Ovary. Reproduction. 2016;: pubmed
    The corticotropin-releasing hormone (CRH) signaling system is involved in numbers of stress-related physiological and pathological responses?including its inhibiting effects on estradiol (E2) synthesis and follicular development in the ..
  69. Nederpelt I, Bunnik J, Ijzerman A, Heitman L. Kinetic Profile of Neuropeptide-Receptor Interactions. Trends Neurosci. 2016;39:830-839 pubmed publisher
    ..hormone receptor (GnRHR), neuropeptide Y receptors, and corticotropin-releasing factor receptor 1 (CRF1R)...
  70. Liu Z, Tang B, Wang X, Chen Q. De-identification of clinical notes via recurrent neural network and conditional random field. J Biomed Inform. 2017;75S:S34-S42 pubmed publisher, a subsystem-based on bidirectional LSTM with features, a subsystem based on conditional random field (CRF) and a rule-based subsystem, are used to identify PHI instances...
  71. Fortes P, Albrechet Souza L, Vasconcelos M, Ascoli B, Menegolla A, de Almeida R. Social instigation and repeated aggressive confrontations in male Swiss mice: analysis of plasma corticosterone, CRF and BDNF levels in limbic brain areas. Trends Psychiatry Psychother. 2017;39:98-105 pubmed publisher
    ..Moreover, corticotropin-releasing factor (CRF) and brain-derived neurotrophic factor (BNDF) were measured in the brain of these animals...
  72. Balseiro Gomez S, Flores J, Acosta J, Ramirez Ponce M, Ales E. Identification of a New Exo-Endocytic Mechanism Triggered by Corticotropin-Releasing Hormone in Mast Cells. J Immunol. 2015;195:2046-56 pubmed publisher
    ..Previous studies have described the effects of corticotropin-releasing hormone (CRH), which is released from inflamed tissues by cellular stress signals, on MC degranulation, a process possibly ..
  73. Tian L, Lu H, Lin L, Hu Y. Effects of aerobic exercise on cancer-related fatigue: a meta-analysis of randomized controlled trials. Support Care Cancer. 2016;24:969-983 pubmed publisher
    Cancer-related fatigue (CRF) is the most commonly reported and most distressing symptom in cancer patients. Currently, there are no effective strategies for managing this condition...
  74. Tenk J, Rostás I, Füredi N, Mikó A, Solymár M, Soós S, et al. Age-related changes in central effects of corticotropin-releasing factor (CRF) suggest a role for this mediator in aging anorexia and cachexia. GeroScience. 2017;39:61-72 pubmed publisher
    Hypothalamic corticotropin-releasing factor (CRF) lays downstream to catabolic melanocortins and at least partly mediates their catabolic effects...
  75. Ni X, Hou Y, King B, Tang X, Read M, Smith R, et al. Estrogen receptor-mediated down-regulation of corticotropin-releasing hormone gene expression is dependent on a cyclic adenosine 3',5'-monophosphate regulatory element in human placental syncytiotrophoblast cells. J Clin Endocrinol Metab. 2004;89:2312-8 pubmed
    Placental CRH plays a major role in the mechanisms controlling human pregnancy and parturition. Understanding how placental CRH production is regulated is therefore of importance...
  76. Grone B, Maruska K. A second corticotropin-releasing hormone gene (CRH2) is conserved across vertebrate classes and expressed in the hindbrain of a basal neopterygian fish, the spotted gar (Lepisosteus oculatus). J Comp Neurol. 2015;523:1125-43 pubmed publisher
    ..We examined the relationship of this second vertebrate CRH gene, which we name CRH2, to CRH1 (previously known as CRH) and urocortin1/urotensin1 (UCN1/UTS1) in primitive fishes, teleosts, and tetrapods...
  77. Smoller J, Rosenbaum J, Biederman J, Kennedy J, Dai D, Racette S, et al. Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition. Biol Psychiatry. 2003;54:1376-81 pubmed
    ..Corticotropin-releasing hormone (CRH) is a key mediator of the stress response through its effects on the hypothalamic-pituitary-adrenal axis and limbic ..
  78. van der Laan S, de Kloet E, Meijer O. Timing is critical for effective glucocorticoid receptor mediated repression of the cAMP-induced CRH gene. PLoS ONE. 2009;4:e4327 pubmed publisher
    ..between the two main signaling pathways involved in activation and repression of corticotrophin releasing hormone (CRH) mRNA expression: cyclic AMP (cAMP) and GR...
  79. Parylak S, Cottone P, Sabino V, Rice K, Zorrilla E. Effects of CB1 and CRF1 receptor antagonists on binge-like eating in rats with limited access to a sweet fat diet: lack of withdrawal-like responses. Physiol Behav. 2012;107:231-42 pubmed publisher
    ..Binge-like intake was unaffected by pretreatment with the corticotropin-releasing factor type 1 (CRF(1)) receptor antagonist R121919, and corticosterone responses to restraint stress did not differ between sweet-fat ..
  80. Sasaki A, Sato N, Suzuki N, Kano M, Tanaka Y, Kanazawa M, et al. Associations between Single-Nucleotide Polymorphisms in Corticotropin-Releasing Hormone-Related Genes and Irritable Bowel Syndrome. PLoS ONE. 2016;11:e0149322 pubmed publisher
    ..A key mediator of the stress response is corticotropin-releasing hormone (CRH)...
  81. Florio P, Severi F, Fiore G, Micheli L, Bocchi C, Nencini C, et al. Impaired uterine artery blood flow at mid gestation and low levels of maternal plasma corticotropin-releasing factor. J Soc Gynecol Investig. 2003;10:294-7 pubmed
    Corticotropin-releasing factor (CRF) is a placental neuropeptide that plays a role in the control of uteroplacental blood flow regulation...
  82. Vitoratos N, Papadias K, Makrakis E, Christodoulakos G, Panoulis K, Creatsas G. Association between serum tumor necrosis factor-alpha and corticotropin-releasing hormone levels in women with preterm labor. J Obstet Gynaecol Res. 2006;32:497-501 pubmed
    To evaluate the association of serum corticotropin-releasing hormone (CRH) and tumor necrosis factor-alpha (TNF-alpha) in preterm labor...
  83. Suwanapaporn P, Chaiyabutr N, Thammacharoen S. A low degree of high ambient temperature decreased food intake and activated median preoptic and arcuate nuclei. Physiol Behav. 2017;181:16-22 pubmed publisher
    ..A separate experiment also showed no differences in the corticotropin-releasing factor (CRF) concentrations from many selected nuclei...
  84. Alvarez B, Barrientos T, Gac L, Teske J, Perez Leighton C. Effects on Hedonic Feeding, Energy Expenditure and Balance of the Non-opioid Peptide DYN-A2-17. Neuroscience. 2018;371:337-345 pubmed publisher
    ..Pre-treatment with a CRF receptor antagonist into PVN blocked the effects of DYN-A2-17 on food intake while injection of DYN-A<..
  85. Manto M. Motor Control: CRF Regulates Coordination and Gait. Curr Biol. 2017;27:R847-R850 pubmed publisher
    ..There is growing evidence that the climbing fibers also tune motor commands. A novel study unravels a role of corticotropin-releasing factor (CRF) in motor coordination and gait control.
  86. Butler R, Ehling S, Barbar M, Thomas J, Hughes M, Smith C, et al. Distinct neuronal populations in the basolateral and central amygdala are activated with acute pain, conditioned fear, and fear-conditioned analgesia. Neurosci Lett. 2017;661:11-17 pubmed publisher
    ..primarily inhibitory (GABAergic) that comprise enkephalin (ENK) interneurons and corticotropin-releasing factor (CRF) - neurons that project to the periaqueductal grey...
  87. Castro Pinero J, Perez Bey A, Segura Jiménez V, Aparicio V, Gomez Martinez S, Izquierdo Gomez R, et al. Cardiorespiratory Fitness Cutoff Points for Early Detection of Present and Future Cardiovascular Risk in Children: A 2-Year Follow-up Study. Mayo Clin Proc. 2017;92:1753-1762 pubmed publisher
    To examine the association between cardiorespiratory fitness (CRF) at baseline and cardiovascular disease (CVD) risk in 6- to 10-year-olds (cross-sectional) and 2 years later (8- to 12-year-olds [longitudinal]) and whether changes with ..
  88. Franklin B, Brinks J, Berra K, Lavie C, Gordon N, Sperling L. Using Metabolic Equivalents in Clinical Practice. Am J Cardiol. 2018;121:382-387 pubmed publisher
    ..employed as a guide to exercise training and activity prescription and to categorize cardiorespiratory fitness (CRF). There are, however, inherent limitations to the concept, as well as common misapplications...
  89. Geenen R, Jacobs J, Bijlsma J. Evaluation and management of endocrine dysfunction in fibromyalgia. Rheum Dis Clin North Am. 2002;28:389-404 pubmed
    ..while patients show marked ACTH hypersecretion in response to severe acute stressors, perhaps indicative of chronic CRH hyposecretion...
  90. Normandeau C, Ventura Silva A, Hawken E, Angelis S, Sjaarda C, Liu X, et al. A Key Role for Neurotensin in Chronic-Stress-Induced Anxiety-Like Behavior in Rats. Neuropsychopharmacology. 2018;43:285-293 pubmed publisher depolarization induced the release of vesicular neurotensin (NT) and corticotropin-releasing factor (CRF) that co-acted to increase ovBNST inhibitory synaptic transmission in 59% of recorded neurons...
  91. Secgin C, Kulah C, Gulsahi A. Analysis of mandibular changes using panoramic-based indices in patients with chronic renal failure. Int J Artif Organs. 2017;: pubmed publisher
    Chronic renal failure (CRF) is a progressive disease affecting many systems and causing dental and periodontal problems, in particular a decrease or loss in the amount of cortical bone that is visible on radiographs...
  92. Fahradpour M, Keov P, Tognola C, Perez Santamarina E, McCormick P, Ghassempour A, et al. Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor. Front Pharmacol. 2017;8:616 pubmed publisher
    ..ipecacuanha) for its GPCR modulating activity of the corticotropin-releasing factor type 1 receptor (CRF1R). We identified and characterized seven novel cyclotides...